Endocytosis
Three types of coated vesicles transport proteinsfrom organelle to organelle
Lodish et al, 2000
Lilly (1993) Pathophysiology of Heart Disease
A single layer of endothelial cells lines arteries
Lilly (1993) Pathophysiology of Heart Disease
Fatty streaks contain macrophage cells with lipid deposits
FibrousPlaques
Calcification
Lilly (1993) Pathophysiology of Heart Disease
Fibrous plaques damage the endothelial layer
Pathology Advances
Ulceration Thrombosis
Brown & Goldstein (1986) Science 232:34
Cholesterol is carried mostly aslow density lipoprotein (LDL) particles
HMGCoA controls the rate limiting stepin cholesterol synthesis
Zubay, 1998
Receptor-mediated endocytosisvia clathrin-coated pits and vesicles
Lodish et al, 2000
Brown & Goldstein (1986) Science 232:34
LDL receptor recycling pathway
EM image of clathrin-coated pitfrom cytosolic side
Lodish et al, 2000
Structure of a clathrin-coated vesicle
Lodish et al, 2000
Smith & Pearse. Trends in Cell Biology, 1999
movie by Allison Bruce
Assembly of clathrin coated vesicle
Assembly and vesiculation of clathrin-coated pits
Lodish et al, 2000
Dynamin is a GTPase required for pinching off ofclathrin-coated vesicles
Lodish et al, 2000
Components that participate inbudding of coated vesicles
Lodish et al, 2000
Top Related