THE ROLE OF THE HPC-PFC PATHWAY AND SCHEMA MECHANISMS IN
PSYCHIATRIC DISEASES
By Siobhan Campbell
Honours Neuroscience Dissertation- Library Project
Introduction
The HPC-PFC Pathway:vHPC vmPFC
The Stress Response - HPA
Walker et al. (2008)
MRs/GRsHPC/PFC
Hypothesis
The HPC-PFC pathway is damaged by stress, disrupting neural function and cognition in psychiatric disease
Outline
Schema
Pathway
Stress & Structure
Stress & Function
Cognition & Disease
Cognition in Disease - Schemas
• Previous knowledge networks• Increase rate of consolidation• Facilitate decision-making• Built upon HPC-PFC interactions
Lewis et al. (2011)
History of ResearchTract-Tracing
1977 – 1995 Electrophysiology
1996 – 2000 Lesions
2004 – 2011
The HPC-PFC
Pathway
Lesions Disrupt Oscillations
vHPC lesions reduces oscillations in vmPFC
Brockmann et al. (2011)
Brain Oscillations
Lewis et al. (2011)
Stress Disrupts Oscillations
Oliveria et al. (2013)
Stress Disrupts Structure
vHPC vPFC @ Layer2
• Stress affects pathway input
• PFC atrophy
Cerqueria et al. (2007)
Stress Disrupts Function@HPC-PFC synapses
LTP memory traces
@CA1 synapses
Booth et al. (2014)
Cerqueria et al. (2007)
Memory in Disease - Depression@HPC-PFC synapses:Stress impairs LTPAntidepressants restore LTP
Rocher et al. (2004)
Memory in Disease - Schizophrenia
Suh et al. (2013)
Memory in Disease - Schizophrenia
Sigurdsson et al. (2010)
Pathway in Disease - Schema
ACC/PrL: • schema• decision-making• stress
Conclusion:Pathway damage could prevent activation of schemas
Tse et al. (2011)
SummaryThe HPC-PFC pathway:1. Exists2. Interacts with stress and disease3. Is involved in creating and updating
schemas
Hypothesis:The HPC-PFC pathway is damaged by stress, disrupting neural function and cognition in psychiatric disease.
Future StudiesSchema & Schizophrenia
Animals - Tse et al. (2007) Humans – Van Kesteren et al. (2010)
Author: Siobhan CampbellSupervisor: Lisa Genzel
Morris LabCCNS
1 George Sq.Edinburgh
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