Decisions

Transcribe gene

Splice RNA

Destroy protein

..Or for the whole cell?

Think small, talk big.

Sydney Brenner

Cooperative Binding

lacZ

Regulated Recruitment

Stepwise

Evolvability

1.3

1.3

1.3

Synergy is easy

Evolvability

‘New’ genes

Evolvability

Specificity depends onconcentration or sequestration

The Price

1.16

1.16

SH2 (P-Tyr)

PTB (P-Tyr)

SH3 (Pro)

FHA (P-Thr)

PH (PIP3)

HTH

HLH

Zn Finger

Winged Helix

Homeodomain

Recruiting Domains

A promoter

…looks like a receptor