COVID-19 Community Readiness: Helping
Meet Needs for Persons Living with Behavioral
Health Issues, Intellectual/Developmental
Disabilities, and Traumatic Brain Injuries
NC Department of Health and Human Services (NCDHHS) • Division of Mental Health Developmental Disabilities and Substance Abuse Services • In partnership with the NCDHHS Historically Marginalized Populations Behavioral Health Workgroup • NCDHHS is an equal opportunity employer and provider. • www.ncdhhs.gov • 11/2020
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Section I. Overview: COVID-19’s Implications on
Mental Health and Substance Abuse Disorder
Beginning March 2020, the coronavirus pandemic, caused by the viral strain known as
SARS CoV-2 (better known as COVID-19), has created widespread public health and
medical crises across populations, communities, and service sectors – nationally and in
the state. North Carolinians have experienced mass hospitalizations, deaths,
employment losses, and behavioral health consequences. COVID-19 has had a
negative impact on persons living with mental health and substance use disorders,
individual/developmental disabilities, and traumatic brain injuries (TBI) (hereafter all
referred as behavioral health).
According to CDC datai collected June 24–30, 2020, from a total of 5,412 adults from
across the US who completed a web-based survey, 40% reported struggling with
mental health or substance use. Among the respondents, 31% reported
symptoms of anxiety and depression, and 26% reported trauma related disorder.
By mid-2020, COVID-19 had taken its toll – the mid-2020 Kaiser Family Foundation
study found 53% of adults in the United States reported their mental health has
been negatively impacted due to worry and stress over the coronavirus.
The Foundation’s study also reported the behavioral health issues people experience
only four months after the onset of the national (and global) COVID-19 pandemic
resulted in an economic recession with job losses, household income declines, and
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housing and food insecurities). The initial sheltering in
place, social isolation, quarantines, and disruptions in
routine behaviors and norms attributed to ongoing
stress and anxiety.
Quarantining and sheltering in place are evidence-
based guidance designed to help protect. However,
remaining where a person lives may not be safe if
there is domestic violence and/or physical and mental
abuse against intimate partners and children. High
unemployment, wage loss, and the threat of housing
evictions could initiate and perpetuate violence in
families and for individuals. Violence in the home can
lead to adverse physical and mental health outcomes,
including a higher risk of chronic disease, substance
use, depression, post-traumatic stress disorder, and
risky sexual behaviors.ii
Section II: COVID-19’s Implications for Individuals
with I/DD, TBI and other Disabilities
Individuals with Intellectual/Developmental Disabilities (I/DD), Traumatic Brain Injuries
(TBIs) and other disabilities face additional challenges that can affect their mental
health. It is well documented that chronic health conditions create an increased risk for
infection and complications from COVID-19. According to the CDC, “adults with
disabilities are three times more likely than adults without disabilities to have heart
disease, stroke, diabetes or cancer.” Facing increased risk for COVID-19 and a
disproportionate impact from social distancing and other efforts to stem the spread of
the virus, implications for individuals with disabilities must be considered. Individuals
with I/DD and TBI have a disproportionate negative impact from the social distancing
and other isolating efforts to reduce spreading COVID.
Individuals with I/DD or TBI commonly depend on others for tasks such as personal
care, accessing the community, supported employment, visiting family and friends,
etc. Efforts to limit the spread of the virus further exacerbated social isolation within this
community. Some people were able to rely on digital devices to connect with family,
friends and resources such as physicians and mental health professionals, individuals
with I/DD or TBI may not have access to devices/technology, internet or smart
phones. Also, direct support professionals who provide support services may be unable
or unwilling to provide the same level of support before the pandemic due to fears,
family obligations, or other restrictions. For clients, skill loss, employment change, and
decrease in established support networks are real threats. Caregivers are subject to
fatigue and/or burnout and also loss or change in their employment.
The resources provided in
this toolkit are not all
inclusive but highlight
multiple services and
supports community
stakeholders can utilize to
help provide assistance to
individuals and families
needing mental health and
substance use services
during the COVID-19
pandemic in NC.
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For children and youth with I/DD, TBI or other disabilities, virtual learning environments and
altered school schedules have created significant additional stress and mental health
challenges for families. Special education services have been disrupted and children and
youth may not have access to the same level of educational, physical, social and emotional
interventions required to reach their full potential. Families in this situation are often faced with
the unsurmountable challenge of meeting the needs of their children without critical supports.
Access to health care including in person physical and mental health appointments
presents an additional concern iv. Appointments help assess the effectiveness of
medication, screen for abuse or neglect, and determine physical conditions. While the
increased use of telehealth creates additional important access for much of the
population, telehealth may still be inaccessible to some individuals with disabilities. In
addition, a fear of COVID-19 exposure and/or restrictions in health care environments
may prevent some individuals from seeking medical or mental health care.
Mental health impacts for those with I/DD, TBI or other disabilities can manifest in the
same ways as the general population. But it is important to consider the additional
barriers and stressors that may be experienced by those who may be more at risk for
COVID-19 and reply more heavily on the social supports.
OVERCOMING BARRIERS: STIGMA AND OTHER OBSTACLES
Stigma can:
• Undermine social cohesion, community inclusion, and encourage social isolation.
• Drive people to hide an illness to avoid discrimination and suffer in silence and self-treat.
• Prevent people from seeking needed health care
• Discourage them from adopting healthy behaviors
• Lead to devastating outcomes e.g. suicidal ideation, disease chronicity,
exacerbation of illness, reinforcing trauma
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It is important, especially during this challenging COVID-19 pandemic when many
people are suffering in silence, that we all work towards eradicating stigma and creating
a safe and open pathway for people who are in need of BH or IDD/TBI support and
treatment to ask for help and get the help they need to support health and wellness,
sustained recovery, and resilience. So how can you help be a supportive resource and
eradicate stigma: A few responses (behaviors, beliefs, perceptions) to monitor:
A few responses (behaviors, beliefs, perceptions) to monitor:
1. Fear and Exclusion: Avoid responding to or seeing persons with a BH, IDD or
TBI as individuals who should be feared and, therefore, be kept out of most
communities. Support community inclusion and equity across service sectors
including at the community level.
2. Authoritarianism: Rid yourself and reject the belief of others that persons with a BH,
IDD, or TBI are irresponsible, so life decisions should be made for them or by others.
Allow people to exercise self-determination and seek to support versus disregarding
the self-efficacy and determination of persons with lived BH, IDD, or TBI experience.
3. Overbearing and dehumanizing benevolence: Yes, benevolence can come in
many ways and despite good intentions, benevolence that renders adults as
children can be dehumanizing and overbearing. Avoid seeing persons with a BH,
IDD, or TBI lived experience as childlike and or unable to make their own decisions.
4. Complicit bystander: Refuse to remain silent when others are reinforcing
stigmas or stigmatizing others. Speak up with you see people with a lived BH,
IDD, or TBI experience being discriminated against. Seek solutions to remove
barriers preventing access to care and inclusive environments and positive
experiences for persons with living with a BH, IDD, or TBI condition.
5. Willful ignorance and closed mindedness: Be willing to learn more and
challenge what you think you know about persons with BH, IDD or TBI conditions.
Prejudice and discrimination are manifested out of ignorance and lack of
knowledge. The more you learn about those whom you perceive as the “other”
the more likely your biases and prejudices will dissipate and change for the better.
What you can do to overcome self-stigma?
1. Understand what stigma is: it’s really not about you. Don’t internalize another
person’s or group’s behavior.
2. Seek professional help to overcome the effect that being stigmatized is having
especially if it is preventing you from asking for help.
3. Be a resource for others; share your experience. Shine the light on what is
happening. Force stigma out front.
4. Be an advocate—speak up
5. Join a support network or organization that advocates for persons with lived BH,
IDD or TBI experience.
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Section III: Hope and Help – Resources and Aid
A message, “How are You Doing?” from Dr. Carrie Brown, Chief Medical Officer, Chief
Medical Office for Behavioral Health and Intellectual/Developmental Disabilities, North
Carolina Department of Health and Human Services
Focusing on your mental health is vitally important including ensuring you know social
distancing does not mean being totally disconnected from others and that it is okay to
ask for help as Dr. Jaquetta Foushee advises, “To Minimize the Mental Health Effects of
COVID-19”:
For additional COVID-19 related videos to view and share visit:
https://www.youtube.com/playlist?list=PLUadR7S9ykdlO5IWNW3yCJ8IBUGZ3c6gY
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Save the following SCOOP message to share with people in your network:
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RESOURCES RELATED TO MENTAL HEALTH, SUBSTANCE USE DISORDERS,
AND IDD DURING THE COVID-19 PANDEMIC — FOR INDIVIDUALS
The Hope4NC Helpline (1-855-587-3463) connects North Carolinians to additional
mental health and resilience supports that help them cope and build resilience during
times of crisis. It is available to everyone in North Carolina’s 100 counties during the
COVID-19 crisis. Hope4NC includes a Crisis Counseling Program tailored for COVID-
19, which will provide immediate crisis counseling services to individuals affected by the
ongoing COVID-19 public health crisis.
• This initiative is in partnership with all seven of the state’s Local Management
Entities/Managed Care Organizations and REAL Crisis Intervention Inc. in
Greenville. Hope4NC is now available for you 24 hours per day, seven days a
week to speak to a live person.
The Hope4Healers Helpline (919-226-2002) is an initiative in partnership with the
North Carolina Psychological Foundation. It provides mental health and resilience
supports for health care professionals, emergency medical specialists, first responders,
other staff who work in health care settings and their families throughout the state who
are experiencing stress from being on the front lines of the state’s COVID-19 response.
• Hope4Healers is also available 24 hours per day, seven days a week for people
to reach out for support from a licensed mental health professional.
The Stronghearts Native Helpline (1-844-762-8483) is a safe domestic, dating and
sexual violence helpline for American Indians and Alaska Natives, offering culturally
appropriate support and advocacy daily from 7 a.m. to 10 p.m. CT.
• The line is anonymous and confidential. Callers reaching out after hours may
connect with The National Domestic Violence Hotline, a non-Native based 24-7
domestic violence helpline by selecting option one. Learn more about their
services: https://www.strongheartshelpline.org/about/
• IMMEDIATE HELP is available on their website by using online chat to connect
one-on-one with a live advocate. Learn more about chat advocacy here:
https://www.strongheartshelpline.org/get-help/chat-advocacy/
NORTH CAROLINIAN ORGANIZATIONS WHO CAN HELP
• The Autism Society of North Carolina improves the lives of individuals with
autism, supports their families, and educates communities. www.autismscoiety-
nc.org
• The Brain Injury Association of North Carolina is a statewide non-profit
organization striving to better the lives of individuals living with brain injury.
https://www.bianc.net/
• The Disability Rights North Carolina is a legal advocacy agency that fights for
the rights of people with disabilities in North Carolina. They handle cases
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involving discrimination, abuse and other rights violations. All of our services are
at no cost to North Carolinians with disabilities. https://disabilityrightsnc.org/
• The North Carolina Children and Youth with Special Health Care Needs Help Line (1-800-737-3028) is a free information and referral source for caregivers of and professionals who work with children and youth who have or are at risk for chronic physical, developmental, behavioral or emotional conditions, needing health services beyond the care that a child typically needs.
• First in Families of North Carolina, FIFNC, helps people with disabilities and their families to believe in their dreams, achieve their goals and give back to others. www.fifnc.org
• Using the Licensed Professional Counselors Association of North Carolina,
families/individuals may locate a North Carolina Licensed Professional Counselor
www.lpcacn.org
• National Alliance on Mental Illness (NAMI) North Carolina works with
dedicated community volunteer leaders to raise awareness and provide essential
education, advocacy, and support so people affected by mental illness can build
better lives. https://naminc.org/
• Professional Organizations that Can Help
National Association of Social Workers- North Carolina Chapter
www.naswnc.org
North Carolina Psychological Association https://www.ncpsychology.org/
North Carolina Psychiatric Association https://www.ncpsychiatry.org/
North Carolina Council on Developmental Disabilities https://nccdd.org/
North Carolina Families United https://www.ncfamiliesunited.org/
Alcohol and Drug Council of North Carolina
https://www.alcoholdrughelp.org/
Recovery Resource Hub https://www.recoveryresourcehub.org/
COMMUNITY SUPPORTS/RESOURCES FOR INDIVIDUALS WITH I/DD AND
OTHER DISABILITIES AND THEIR FAMILIES
• Autism Society of North Carolina (ASNC) provides information about autism,
services and supports available to individuals with autism and their families and
how to navigate them. They also have Autism Resource Specialists with lived
experiences who provide support for families. www.autismsociety-nc.org
• Brain Injury Association of North Carolina (BIANC) is an organization that
offers workshops and trainings, support for individuals and families, a resource
directory, and a Family Helpline for families to call about resources related to
brain injury. www.bianc.net
• Centers for Independent Living are non-residential, 501 (c) (3) non-profit
corporations. They are consumer-controlled, community-based organizations that
provide programs and services for people with all types of disabilities and their
families. For a list of NC Centers for Independent Living: https://ncsilc.org/centers/
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• Children with Special Health Care Needs Help Line: 1-800-737-3028 is a
service offered by the Department of Public Health, Children and Youth Branch
to assist families whose children have special health care needs in locating
services, supports and resources for through referral and information.
• Exceptional Children’s Assistance Center is an organization that helps
individuals and families navigate the special education system and process. They
have a robust website with information, toolkits and more about things such as
IEPs, 504 plans, advocacy tips and mental health concerns. They offer
workshops for parents and have Parent Educators that can provide individual
information or assistance. www.ecac-parentcenter.org
• Family Support Network of NC is an organization that provides support and
education to families of children with special needs. They offer Parent-to-Parent
Support, support groups and workshops as well as assistance with navigating
systems and referrals to other services and resources throughout the community.
http://www.fsnnc.org
• First in Families of North Carolina is an organization that compliments formal
services, provides support when other resources are not available and connect
individuals with disabilities and their families to other services. http://fifnc.org
• Local Management Entities-Managed Care Organizations (LME-MCOs) are
public managed care organizations that provide comprehensive behavioral health
services for children and adults with mental health, developmental disabilities,
traumatic brain injury, and substance use needs. To inquire about or request
services, call the appropriate LME-MCO’s Access Line.
https://www.ncdhhs.gov/providers/lme-mco-directory
• NC Division of Aging and Adult Services works to promote the independence
and enhance the dignity of North Carolina's older adults, persons with disabilities
and their families through a community-based system of opportunities, services,
benefits and protections. https://www.ncdhhs.gov/divisions/daas
• NC Division of Vocational Rehabilitation Services (DVRS) helps people with
disabilities achieve their goals for employment and independence. If you have a
disability that prevents you from achieving career success or independence in
the community of your choice, DVRS can connect you to services and resources
to help you meet your goals. https://www.ncdhhs.gov/divisions/dvrs
• The Arc of North Carolina is an organization for people with I/DD and their
families that offers direct supports as well as a variety of programs related to
housing, guardianship, employment, skill building, resource navigation, etc.
There are local chapters throughout NC. https://www.arcnc.org
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RESOURCES TO HELP MANAGE YOUR MENTAL HEALTH
• Tips to reduce anxiety and stress: The American Psychological Association
shares tips to cope with COVID-19 and the impact of social distancing on one’s
mental health.
• Tips for social distancing, quarantine, and isolation: The Substance Abuse
and Mental Health Services Administration suggests ways to cope and support
oneself during an infectious disease outbreak.
• Looking after your mental health: The World Health Organization has
published tips and advice to look after one’s mental health and help others who
may need extra support and care.
• Additional resources available to support mental health and coping with
COVID-19: The Suicide Prevention Resource Center compiled a selection of web
pages and information from key organizations in the field. Resources are
available for general audiences, mental health professionals, health care
workers/first responders, community leaders, American Indians/Alaska Natives,
colleges/universities, schools, parents/caregivers, teenagers, older adults,
Hispanics/Latinos, LGBTQ, faith communities, and workplaces
RESOURCES FOR PERSONS DEALING WITH INTIMATE PARTNER
VIOLENCE AND CHILD ABUSE
• “How COVID-19 may increase domestic violence and child abuse” created by
SAMHSA, available at: www.apa.org/topics/covid-19/domestic-violence-child-abuse
• Addiction Technology Transfer Center (ATTC) offers a a one-hour self-paced
course based on industry awareness about Intimate Partner Violence (IPV):
https://healtheknowledge.org/course/view.php?id=18
• “Intersection of Domestic Violence or Intimate Partner Violence and
Addiction” (Webinar) by the National Hispanic and Latino ATTC:
https://attcnetwork.org/centers/national-hispanic-and-latino-
attc/product/intersection-domestic-violence-or-intimate
• Supporting Survivors’ Access to Substance Use Disorder and Mental Health
Services During the COVID-19 Emergency released by The National Center on
Domestic Violence, Trauma & Mental Health (a SAMHSA partner):
www.nationalcenterdvtraumamh.org/2020/03/covid-19-resources-for-advocates/
• National Domestic Violence Hotline: 1-800-799-SAFE (7233),
www.thehotline.org/resources/staying-safe-during-covid-19/
• Strong Hearts Native Helpline provides domestic violence support for
Native/American Indians, www.strongheartshelpline.org/get-help/
• Mitigating the Effect of COVID as an Adverse Childhood Experience (ACE)
with Positive Childhood Experiences (webinar) by Zero Abuse Project,
www.zeroabuseproject.org/trainings/mitigating-the-impact-of-covid-19-as-an-
adverse-childhood-experience-ace-with-positive-childhood-experiences/
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RESOURCES ON CHILDREN FOR PARENTS
• Helping children cope with changes resulting from COVID-19: The National
Association of School Psychologists provides tips on helping families adjust to a
“new normal”
• Parent/Caregiver guide to helping families cope with COVID-19: The
National Child Traumatic Stress Network includes age-appropriate tips for
helping children cope with stress and uncertainty
• Tips for parents during times of trauma: Parents As Teachers outlines ways
caregivers can maintain routines and respond to children’s needs. Parents and
caregivers can also search for a Parents As Teachers program in their area
• Supporting Individuals with Autism through Uncertain Times: The UNC
Frank Porter Graham Child Development Institute Autism Team developed this
toolkit to provide strategies to help individuals with autism cope with the stress
and uncertainty often felt during the pandemic.
• Children with Special Health Care Needs Help Line: 1-800-737-3028 is a
service offered by the Department of Public Health, Children and Youth Branch
to assist families whose children have special health care needs in locating
services, supports and resources for through referral and information. Email:
• Exceptional Children’s Assistance Center is an organization that helps
individuals and families navigate the special education system and process. They
have a robust website with information, toolkits and more about things such as
IEPs, 504 plans, advocacy tips and mental health concerns. They offer
workshops for parents and have Parent Educators that can provide individual
information or assistance. www.ecac-parentcenter.org
• The National Child Traumatic Stress Network provides various resources,
such as “What Is Child Trauma – Pandemic Resources”, “Helping Children Cope
with COVID-19” and “Coping in Hard Times for Parents”
• Lessons from children’s book Trinka and San Fighting the Big Virus, available
in both English and Spanish.
• The American Academy of Child and Adolescent Psychiatry has a main
page with a number of excellent resources
• “Helping Homebound Children during the COVID-19 Outbreak published by the
Center for the Study of Traumatic Stress
• “Parenting during a Pandemic” published by the AAP
• The Sesame Street Workshop (helpful information on Caring for Each Other
including resources for younger children, i.e. sesame stress in communities
resources, how to talk to kids, printable activities, etc.) Available in
English/Spanish
https://www.sesamestreet.org/caring
https://sesamo.com/cuidandonos/
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NORTH CAROLINA-SPECIFIC COVID-19 POLICIES AND GUIDANCE
• COVID-19 Prevention Supports in NC: DHHS COVID-19 information HUB
https://www.nc.gov/covid19
• If you are an organization or agency that would like to find out how you can
access Personal Protective Equipment (PPE), visit https://ncadmin.nc.gov/about-
doa/divisions/purchase-and-contract/consolidated-ppe-supply-service-portal
• Pandemic Preparedness for the workplace and the ADA (Source: US EEOC)
https://www.eeoc.gov/laws/guidance/pandemic-preparedness-workplace-and-
americans-disabilities-act
PROMOTING HEALTHY BEHAVIORS THAT PREVENT AND REDUCE THE
SPREAD OF COVID-19
Community stakeholders including providers, peer-led organizations, advocacy groups,
CBOs and FBOs should remain vigilant in promoting and implementing strategies to
encourage behaviors that reduce the spread of COVID-19 including practicing the 3Ws:
Wearing a face covering over nose and mouth is an evidence-based preventive
measure that can help reduce the risk of spreading the novel coronavirus COVID19.
For details about why and how to wear a protective face covering appropriately visit
DHHS’s website and link to https://covid19.ncdhhs.gov/information/individuals-families-
and-communities/cloth-face-coverings-and-masks
Require the use of face coverings among staff and volunteers, when feasible. Face
coverings (specifically covering your nose and mouth) are most essential in times when
social distancing is difficult. Information should be provided to all staff and volunteers on
proper use, removal, and washing of face coverings. There are instances when face
coverings should not be used including on:
✓ Babies or children younger than 2 years old;
✓ Anyone who has trouble breathing;
✓ Anyone who is unconscious, incapacitated, or otherwise unable to remove the
face covering without assistance.
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Face coverings are meant to protect other people in case the wearer may have the virus
and not know it. Face coverings are not meant to be a substitute for critical protective
equipment such as surgical masks, respirators, or other medical personal protective
equipment. Encourage clients and other stakeholders coming to your facility or
attending events to bring and use face coverings.
Wait: As restrictions begin to ease related to interacting with others in public, make sure
that you are maintaining a healthy distance between yourself and others when out in
public. Wait until you are at least 6 feet (two arms length) between another person;
maintain that distance as much as possible.
Wash: Practice good hand hygiene and respiratory etiquette
Fact: Washing your hands frequently and especially after contacting surfaces and
others is an important hygiene practice to prevent the spread of COVID-19. Make sure
that you are washing with soap and water for at least 20 seconds during each wash. If
soap and water are not readily available, hand sanitizer that contains at least 60%
alcohol can be used; rub hands together until dry.
It is also important to practice good respiratory etiquette by covering coughs and
sneezes with a tissue or in your inner arm at the elbow to prevent the spread. This
should be done even if you are wearing a face covering. If out in public or meeting and
greeting someone, use alternate forms of greeting besides handshakes, hugs, and
kissing. For example, introduce a new practice of waving, bowing or elbow touch.
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References:
i Czeisler MÉ , Lane RI, Petrosky E, et al. Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic — United States, June 24–30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:1049–1057. DOI: http://dx.doi.org/10.15585/mmwr.mm6932a1external icon ii Czeisler MÉ , Lane RI, Petrosky E, et al. Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic — United States, June 24–30, 2020. MMWR Morb Mortal Wkly Rep 2020;69:1049–1057. DOI: http://dx.doi.org/10.15585/mmwr.mm6932a1external icon ii Panchal, N., Kamal, R., Orgera, K., Cox, C., Garfield, R., Hamel, L., Muñana, C., and Chidambaram, P. (2020). The Implications of COVID-19 for Mental Health and Substance Use. August 21, 2020. www.kff.org/coronavirus-covid-19/issue-brief/the-implications-of-covid-19-for-mental-health-and-substance-use/ ii SAMSHA,Intimate Partner Violence and Child Abuse Considerations During COVID19 (white paper) www.samhsa.gov/sites/default/files/social-distancing-domestic-violence.pdf
Iv John N. Constantino, M.D., Mustafa Sahin, M.D., Ph.D., Joseph Piven, M.D., Rylin Rodgers, B.S., John Tschida, M.P.P. (2020, August 28). The Impact of COVID-10 on Individuals with Intellectual and Developmental Disabilities: Clinical and Scientific Priorities. The American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2020.20060780 V Avalere Health Impact of COVID-19 on Organizations Serving Individuals with Intellectual and Developmental Disabilities. www.ancor.org/sites/default/files/impact_of_covid-19_on_organizations_serving_individuals_with_idd.pdf Vi Centers for Disease control and Prevention. (2020, September 11). People with Disabilities. www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-disabilities.html vii Corrigan, J. D. (2005). Substance abuse. In W. M. High, Jr., A. M. Sander, M. A. Struchen, & K. A. Hart (Eds.), Rehabilitation for traumatic brain injury (pp. 133–155). New York: Oxford University Press. ii Goffman E. Stigma: Notes on the management of spoiled identity. London: Penguin; 1963. ii Corrigan and Watson, 2002. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489832/
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