Case File-2
A 61-year-old man is noticed to have increased intraocular pressure on a routine eye examination. The visual acuity is normal in both eyes. The dilated eye examination reveals no evidence of optic nerve damage. Visual field testing shows mild loss of peripheral vision. He is diagnosed with primary open-angle glaucoma and is started on pilocarpine ophthalmic drops.
Questions 1. What is the action of pilocarpine on
the muscles of the iris and cilia?2. What receptor mediates this action?3. Is pilocarpine the appropriate first-
line drug for the treatment of primary open-angle glaucoma?
Summary A 61-year old man with open-angle
glaucoma is prescribed pilocarpine ophthalmic drops
Action of pilocarpine on muscles of the iris and cilia
Constriction of the muscles
Receptor that mediates this action
Muscarinic cholinoreceptor
First line drugs to treat primary open-angle glaucoma
Prostaglandin analogs
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