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SOURCES FOR THERAPEUTIC AGENTS
PLANTEXTRACTS
BACTERIALBROTHS
ANIMALVENOMS
SMALLMOLECULE
DRUGS
BIOLOGICALMOLECULES
PHARMACEUTICALS
BIOPHARMACEUTICALS
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History of therapeutic agents
Regulation
Ancient remedies
Natural products (first half s XX)
Medicinal Chemistry (1950)
Biotechnology (1982)
Regulation
Regulation
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724 Drug stores: Arabian pharmacists in Bhagdag
s XIII First pharmacopeas
S XIX Drug stores converted into larger pharmaceutical companies
1906 FDA creation (misbranded foods and drugs)
1920 Insulin, Penicillin were mass manufactured and distributed
1938 Toxicity studies were required
1950 Numerous drugs: the pill, cortisone, blood pressure drugs,MAO inhibitors, Thorazine, Haloperidol or Diazepam.
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1960 Thalidomide
1962 Proof of efficacy was required
1970 Cancer drugs
1978 First production in India without protection
1980 Small biotech companies
1982 Rcombinant Insulin
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THALIDOMIDE
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PRECLINICALSTUDIES
CLINICALSTUDIES
DEVELOPMENT
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ANAESTHETICS
ANALGESICS
ANTIDOTES
ANTI-INFECTIVE MEDICINES ANTI-MIGRAINE MEDICINES
ANTINEOPLASTIC AND IMMUNODEPRESSIVES
ANTIPARKINSON MEDICINES
MEDICIENS AFFETING THE BLOOD BLOOD PRODUCTS AND PLASMA SUBSTITUTES
CARDIOVASCULAR MEDICINES
DERMATOLOGICAL MEDICINES
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DIAGNOSTIC AGENTS
DESINFECTANTS AND ANTISEPTICS
DIURETICS
GASTROINTESTITAL MEDICINES HORMONES
IMMUNOLOGICALS
MUSCLE RELAXANTS
OPHTALMIOLOGICAL PREPARATIONS OXYTOCICS
PERITONEAL DIALYSIS SOLUTION
PSYCHOTHERAPEUTIC MEDICINES
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MEDICINES ACTING ON THE RESPIRATORY
TRACT
SOLUTIONS CORRECTING WATER,
ELECTROLYTE AND ACID-BASE DISTURBANCES
VITAMINS AND MINERALS
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SOURCES FOR THERAPEUTIC AGENTS
PLANTEXTRACTS
BACTERIALBROTHS
ANIMALVENOMS
SMALLMOLECULE
DRUGS
BIOLOGICALMOLECULES
PHARMACEUTICALS
BIOPHARMACEUTICALS
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Hormones: insulin, growth hormone
Thrombolytic agents
Blood factors: factor VIII, factor IX Haematopietic growth:
Interferons
Interleukin based products
Monoclonal antibodies Antisense therapy
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Paradigm: Biological Actions are receptor mediated
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G1
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