XT-1800 iHaematology is Fluorescence Flow Cytometry
XT-18
.CA.C.69
9-ICE.3
/06
Success of excellence built on the fluorescence flow cytometry
platform of sysmex xe-2100 reliable system requiring minimum main-
tenance ( just one shutdown cycle/day)
Valuable information with diagnostic impact excellent WBC differential with low review
rate due to specific fluorochrome staining accurate RBC and PLT count determined
by a hydrodynamic focussing system cumulative patient data and Delta Check
Easy to use Windows user interface q-flags for quantitative flagging to adapt
diagnostic sensitivity to laboratory needs comprehensive software programs
for internal and external QC on board
Cost effective two random access selective test profiles
(CBC, CBC/DIFF) real-time bidirectional
Host communication network capability for integration
into a productive laboratory environment sncs (sysmex network communication
system) for efficient user support
Flexibility information processing unit (IPU)
with customisable display tcm allows to connect two xt-1800i
instruments to a single IPU,creating a common database
optional components for flexible configurations
Design and specifications may be subjectto change due to further product development.
Technologies
Parameters
Throughput
Aspiration volume
Data storage
Quality control
Interfaces
Options
Configurations
Dimensions / weightsw x hxd [mm] / [kg]
fluorescence flow cytometry: WBC DIFF, IGDC sheath flow method: RBC, HCT, PLTcyanide-free SLS method: HGBWBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT NEUT (%, #) LYMPH (%, #), MONO (%, #), EO (%, #), BASO (%, #),RDW-SD, RDW-CV, MPV, P-LCR, PDW, PCT research parameters: IG (%, #), OTHER (%, #)stand-alone: 80 samples/hourtwin: 160 samples/hour150L for sampler/manual closed mode85 L for manual open mode40 L sample volume for capillary mode 10,000 samples (incl. graphics)5,000 patients information1,000 selective test orders20 QC files with 300 data points each 1 XbarM file with 300 data pointsoptional: sncs online qcHost (Ethernet or serial),graphic printer (parallel or USB)rack sampler for 50 sample tubesbar code reader for sampler mode, manual cap piercer unithand-held bar code reader, xt-pro software modulestand-alone (pim*), twin (tcm*)
530 x 630 x 720 /59 (main unit with sampler)280 x 400 x 355 / 17 (pneumatic unit)305 x 85 x 345 / 8 (IPU: information processing unit)
SYSMEX CORPORATION1-5-1, Wakinohama-Kaigandori, Chuo-kuKobe 651- 0073, JapanPhone +81 (78) 265-0521 Fax +81 (78) 265-0530 www.sysmex.co.jpSYSMEX EUROPE GMBHBornbarch 1, 22848 Norderstedt, GermanyPhone +49 (40) 527 26-0 Fax +49 (40) 527 26-100 www.sysmex-europe.comSYSMEX DEUTSCHLAND GMBHBornbarch 1, 22848 Norderstedt, Germany Phone +49 (40) 53 41 02-0 Fax +49 (40) 523 23 02www.sysmex.de
SYSMEX UK LTD.Sysmex House, Garamonde Drive, WymbushMilton Keynes, Buckinghamshire, MK8 8DF, U. K.Phone +44 (870) 902 92 10 Fax +44 (870) 902 92 11www.sysmex.co.ukSYSMEX FRANCE S. A. S.Z. I. Paris Nord II, 22 Avenue des NationsBP: 51414 Villepinte 95944 Roissy CDG Cedex, FrancePhone +33 (1) 48 17 01 90 Fax +33 (1) 48 63 23 50SYSMEX DANMARKMsvrvej 23, 6051 Almind, Denmark Phone +45 70 20 45 01 Fax +45 70 20 45 41www.sysmex.dk
SYSMEX SVERIGEMarios Gata 13, 43437 Kungsbacka, SwedenPhone +46 (300) 56 72 02 Fax +46 (300) 56 72 03www.sysmex.seSYSMEX NORGEHvamsvingen 24, 2013 Skjetten, NorwayPhone +47 63 84 01 60 Fax +47 63 84 31 40www.sysmex.noSYSMEX POLSKA SP. Z O.O.Kopernik Office Building III Al. Jerozolimskie 176, 02-486 Warsaw. Poland Phone +48 (22) 5 72 84-00 Fax +48 (22) 5 72 84- 10www.sysmex.pl
* pim = patient information manager, tcm = twin configuration manager
Folder XT-1800i_PPS.qxd 01.03.2006 18:28 Uhr Seite 1
Compact fully automated Fluorescence Flow Cytometerfor high quality haematology analysis
State-of-the-art technology
A look insideWith fluorescence flow cytometry individual blood cells stained by fluorochromes are illuminated by asemi-conductor laser beam, enab-ling a sophisticated analysis basedon RNA/DNA content, cell size, andinner cell complexity. Looking intothe cell and judging the metabolicactivities in respect to cell replica-tion and protein synthesis offersmuch advanced possibilities for thedetermination of the cell type andmaturation stage.
The collection and fast processing of three optical signals obtained from each individual cell are thebasis for the cell identification.When it comes to white blood celldifferentiation, analysing the cellinterior properties rather than cellsize leads to reliable classificationalso in older samples and clearlyreduces interferences.
Using sysmex unique adaptivecluster analysis system (acas)instead of fixed discriminators re-sults in correct cell clustering andthus WBC differential counts also inhighly pathologic samples, accord-ingly reducing the false positiverate. The results are illustrated ininformative scattergrams.
In the optical unit of xt-1800ia semi-conductor laser, the flow cell,optical focussing systems and detectorsare combined in a sophisticated system.
The forward scattered light signal (cell size information), the side scatteredlight signal (internal cell structure) and the side fluorescence light signal(RNA/DNA information) of each cell areanalysed as it passes through the flowcell.
RNA/DNA information
photo multiplier(fluorescence light)
photo diode(forward scattered light)
flow cell
semi-conductor laser = 633 nm dichroic
mirror
photo diode(side scattered
light)
laser beam = 633 nm
internal cell structure
cell size
The various WBC populations andimmature precursor cells show a spe-cific reaction with the fluorescent dye.
1 Neutrophil, 2 Eosinophil, 3 Basophil,4 Monocyte, 5 Lymphocyte,6 Band, 7 Metamyelocyte, 8 Myelocyte,9 Promyelocyte, 10 Blast
1 2 3 4 5
6 7 8 9 10
The xt information processing unit (IPU)The main unit and the completeoperation of the xt-1800i is controlledby the operator via the informationprocessing unit with interactivemenus. Intuitively understandableicons are used for the graphical userinterface of Windows.
In the IPU data base, all analysis re-sults and patient data including thecomplete set of scattergrams andhistograms of up to 10,000 samplesare stored.
Back-up facilities on CD-RW offer principally unlimited storage capa-city. Quality control programs allowunattended analysis of control blood samples in closed auto-sampler modeor in manual mode.
The multi-tasking computer systempermits real time bidirectional com-munication with the Host computer to request patient profiles fordiscrete testing with patient demo-graphical information and transmitsanalysis results immediately afteranalysis is completed. Even if thesystem is operated offline and with-out bar code system, selective sampleanalysis is maintained by using thework list function.
FlexibilityThe sysmex xt-1800i is available in multiple configurations. This offershigh flexibility and satisfies even theneeds of the most demanding hae-matology laboratory.
A 50-tube auto-sampler can bemounted on the main unit of theanalyser offering walkaway auto-mation. This sampler system enablescontinuous feeding of samples witha throughput rate of 80 samples perhour. A STAT function allows imme-diate analysis of emergency samples.
If desired, it is possible to install amanual cap piercer system insteadof the sampler.
No matter whether a manual or anautomated bar code reader is used,adequate positive sample identifica-tion gives confidence.
The complete main unit operation and all data management functions are performed on theinformation processing unit (IPU).
The optional sampler unit of xt-1800iensures efficient operation and through-put of 80 samples per hour, independentof the parameter profiles analysed.
The cap piercer unit of xt-1800i.
Folder XT-1800i_PPS.qxd 01.03.2006 18:28 Uhr Seite 3
Compact fully automated Fluorescence Flow Cytometerfor high quality haematology analysis
State-of-the-art technology
A look insideWith fluorescence flow cytometry individual blood cells stained by fluorochromes are illuminated by asemi-conductor laser beam, enab-ling a sophisticated analysis basedon RNA/DNA content, cell size, andinner cell complexity. Looking intothe cell and judging the metabolicactivities in respect to cell replica-tion and protein synthesis offersmuch advanced possibilities for thedetermination of the cell type andmaturation stage.
The collection and fast processing of three optical signals obtained from each individual cell are thebasis for the cell identification.When it comes to white blood celldifferentiation, analysing the cellinterior properties rather than cellsize leads to reliable classificationalso in older samples and clearlyreduces interferences.
Using sysmex unique adaptivecluster analysis system (acas)instead of fixed discriminators re-sults in correct cell clustering andthus WBC differential counts also inhighly pathologic samples, accord-ingly reducing the false positiverate. The results are illustrated ininformative scattergrams.
In the optical unit of xt-1800ia semi-conductor laser, the flow cell,optical focussing systems and detectorsare combined in a sophisticated system.
The forward scattered light signal (cell size information), the side scatteredlight signal (internal cell structure) and the side fluorescence light signal(RNA/DNA information) of each cell areanalysed as it passes through the flowcell.
RNA/DNA information
photo multiplier(fluorescence light)
photo diode(forward scattered light)
flow cell
semi-conductor laser = 633 nm dichroic
mirror
photo diode(side scattered
light)
laser beam = 633 nm
internal cell structure
cell size
The various WBC populations andimmature precursor cells show a spe-cific reaction with the fluorescent dye.
1 Neutrophil, 2 Eosinophil, 3 Basophil,4 Monocyte, 5 Lymphocyte,6 Band, 7 Metamyelocyte, 8 Myelocyte,9 Promyelocyte, 10 Blast
1 2 3 4 5
6 7 8 9 10
The xt information processing unit (IPU)The main unit and the completeoperation of the xt-1800i is controlledby the operator via the informationprocessing unit with interactivemenus. Intuitively understandableicons are used for the graphical userinterface of Windows.
In the IPU data base, all analysis re-sults and patient data including thecomplete set of scattergrams andhistograms of up to 10,000 samplesare stored.
Back-up facilities on CD-RW offer principally unlimited storage capa-city. Quality control programs allowunattended analysis of control blood samples in closed auto-sampler modeor in manual mode.
The multi-tasking computer systempermits real time bidirectional com-munication with the Host computer to request patient profiles fordiscrete testing with patient demo-graphical information and transmitsanalysis results immediately afteranalysis is completed. Even if thesystem is operated offline and with-out bar code system, selective sampleanalysis is maintained by using thework list function.
FlexibilityThe sysmex xt-1800i is available in multiple configurations. This offershigh flexibility and satisfies even theneeds of the most demanding hae-matology laboratory.
A 50-tube auto-sampler can bemounted on the main unit of theanalyser offering walkaway auto-mation. This sampler system enablescontinuous feeding of samples witha throughput rate of 80 samples perhour. A STAT function allows imme-diate analysis of emergency samples.
If desired, it is possible to install amanual cap piercer system insteadof the sampler.
No matter whether a manual or anautomated bar code reader is used,adequate positive sample identifica-tion gives confidence.
The complete main unit operation and all data management functions are performed on theinformation processing unit (IPU).
The optional sampler unit of xt-1800iensures efficient operation and through-put of 80 samples per hour, independentof the parameter profiles analysed.
The cap piercer unit of xt-1800i.
Folder XT-1800i_PPS.qxd 01.03.2006 18:28 Uhr Seite 3
XT-1800 iHaematology is Fluorescence Flow Cytometry
XT-18
.CA.C.69
9-ICE.3
/06
Success of excellence built on the fluorescence flow cytometry
platform of sysmex xe-2100 reliable system requiring minimum main-
tenance ( just one shutdown cycle/day)
Valuable information with diagnostic impact excellent WBC differential with low review
rate due to specific fluorochrome staining accurate RBC and PLT count determined
by a hydrodynamic focussing system cumulative patient data and Delta Check
Easy to use Windows user interface q-flags for quantitative flagging to adapt
diagnostic sensitivity to laboratory needs comprehensive software programs
for internal and external QC on board
Cost effective two random access selective test profiles
(CBC, CBC/DIFF) real-time bidirectional
Host communication network capability for integration
into a productive laboratory environment sncs (sysmex network communication
system) for efficient user support
Flexibility information processing unit (IPU)
with customisable display tcm allows to connect two xt-1800i
instruments to a single IPU,creating a common database
optional components for flexible configurations
Design and specifications may be subjectto change due to further product development.
Technologies
Parameters
Throughput
Aspiration volume
Data storage
Quality control
Interfaces
Options
Configurations
Dimensions / weightsw x hxd [mm] / [kg]
fluorescence flow cytometry: WBC DIFF, IGDC sheath flow method: RBC, HCT, PLTcyanide-free SLS method: HGBWBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT NEUT (%, #) LYMPH (%, #), MONO (%, #), EO (%, #), BASO (%, #),RDW-SD, RDW-CV, MPV, P-LCR, PDW, PCT research parameters: IG (%, #), OTHER (%, #)stand-alone: 80 samples/hourtwin: 160 samples/hour150L for sampler/manual closed mode85 L for manual open mode40 L sample volume for capillary mode 10,000 samples (incl. graphics)5,000 patients information1,000 selective test orders20 QC files with 300 data points each 1 XbarM file with 300 data pointsoptional: sncs online qcHost (Ethernet or serial),graphic printer (parallel or USB)rack sampler for 50 sample tubesbar code reader for sampler mode, manual cap piercer unithand-held bar code reader, xt-pro software modulestand-alone (pim*), twin (tcm*)
530 x 630 x 720 /59 (main unit with sampler)280 x 400 x 355 / 17 (pneumatic unit)305 x 85 x 345 / 8 (IPU: information processing unit)
SYSMEX CORPORATION1-5-1, Wakinohama-Kaigandori, Chuo-kuKobe 651- 0073, JapanPhone +81 (78) 265-0521 Fax +81 (78) 265-0530 www.sysmex.co.jpSYSMEX EUROPE GMBHBornbarch 1, 22848 Norderstedt, GermanyPhone +49 (40) 527 26-0 Fax +49 (40) 527 26-100 www.sysmex-europe.comSYSMEX DEUTSCHLAND GMBHBornbarch 1, 22848 Norderstedt, Germany Phone +49 (40) 53 41 02-0 Fax +49 (40) 523 23 02www.sysmex.de
SYSMEX UK LTD.Sysmex House, Garamonde Drive, WymbushMilton Keynes, Buckinghamshire, MK8 8DF, U. K.Phone +44 (870) 902 92 10 Fax +44 (870) 902 92 11www.sysmex.co.ukSYSMEX FRANCE S. A. S.Z. I. Paris Nord II, 22 Avenue des NationsBP: 51414 Villepinte 95944 Roissy CDG Cedex, FrancePhone +33 (1) 48 17 01 90 Fax +33 (1) 48 63 23 50SYSMEX DANMARKMsvrvej 23, 6051 Almind, Denmark Phone +45 70 20 45 01 Fax +45 70 20 45 41www.sysmex.dk
SYSMEX SVERIGEMarios Gata 13, 43437 Kungsbacka, SwedenPhone +46 (300) 56 72 02 Fax +46 (300) 56 72 03www.sysmex.seSYSMEX NORGEHvamsvingen 24, 2013 Skjetten, NorwayPhone +47 63 84 01 60 Fax +47 63 84 31 40www.sysmex.noSYSMEX POLSKA SP. Z O.O.Kopernik Office Building III Al. Jerozolimskie 176, 02-486 Warsaw. Poland Phone +48 (22) 5 72 84-00 Fax +48 (22) 5 72 84- 10www.sysmex.pl
* pim = patient information manager, tcm = twin configuration manager
Folder XT-1800i_PPS.qxd 01.03.2006 18:28 Uhr Seite 1
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