Bioproduction solutionsDateName
2 04/21/23 | Life Technologies™
bioproduction solutionsbioproduction solutionsfrom molecule to marketfrom molecule to market
CellCellTherapyTherapy
Therapeutic Therapeutic Protein Protein
ProductionProductionMicrobialMicrobial
Expression and Expression and ProductionProduction
ViralViralVaccineVaccine
ProductionProduction
Products and services Working with us Why us? Summary
Setting new standards from molecule to marketIntroducing bioproduction solutions from Life Technologies
About us
4 04/21/23 | Life Technologies™
5 04/21/23 | Life Technologies™
Life Technologies is a global biotechnology leader dedicated to making life even better
• 160+ Countries served• $3.6B global leader• 1B$ Revenue in Pharma / Biotech space• 300M$ Revenue in Diagnostics space• 75000+ customers• 50,000 + products• 3,900+ patents and licenses• 10,000 employees• >1,000 New Product Introductions per year• Industry recognition as a life science leader
LifeTechnologies.com
6 04/21/23 | Life Technologies™
Bioproduction is leading positive transformation in biologics production
• 24 of the Top 25* pharmaceutical companies worldwide use a LIFE bioproduction solution, many with multi-site adoptions
• A majority of future biotherapeutics currently in Phase 1-3 development use a LIFE bioproduction solution**
• A large number of launched biotherapeutics today are manufactured using a LIFE bioproduction solution***
* Based on list of Top 50 companies from PharmExec 50, Pharmaceutical Executive Magazine, May 2011** Based on analysis using the Pharmaprojects Database - Pharmaceutical Research & Development Pipeline Intelligence, © Informa UK Ltd ***Based on analysis of list of Top 200 Pharmaceutical Products, The Njardarson Group, Cornell University
Gibco®Cell Culture
POROS®Chromatography
Applied Biosystems®
SEQ Analytics
CellularMedicine
Leader in mAb polish
chromatography
Leader in mAb polish
chromatography
Leader in contaminant and impurity testing
Leader in contaminant and impurity testing
New solutions for cell
therapy, regenerative
medicine
New solutions for cell
therapy, regenerative
medicine
Leader in media and feeds for
50 years
Leader in media and feeds for
50 years
Bioproduction
7 04/21/23 | Life Technologies™
Bioproduction solutions are used by small to large companies across six continents
Europe31%
Americas34%
Asia Pacific13%
Japan16%
Other6%
Contract Services16%
Large Bio/Pharma57%
Sm/Med Bio/Pharma
14%
Animal Health11%
Designed for Phase 1-3process development
to large-scale manufacturing
Designed for Phase 1-3process development
to large-scale manufacturing
Bioproduction solutionsBioproduction solutions
Revenue, by GeographyRevenue, by Geography Revenue, by Customer SegmentRevenue, by Customer Segment
8 04/21/23 | Life Technologies™
Vaccines Shift from egg-based to cell culture-based
Biosimilars More drugs coming off patent, need for shorter time to end-user
Cells, Media Standardization of cell lines, demand for shorter timelines, final product quality, higher titers
Product safety Heightened concerns and risk of contamination
Purification bottlenecks Need to support faster scale-up and manufacturing
Cell therapy Need for complete workflow solutions
Ease of use Major shift to disposables in upstream/downstream, automation for analytics
Solutions respond to urgent industry trends
9 04/21/23 | Life Technologies™
Freedom™ CHO Cell LinesSimplified commercial cell line development
with optimized workflows andunprecedented IP access
Freedom™ CHO Cell LinesSimplified commercial cell line development
with optimized workflows andunprecedented IP access
POROS® XS Chromatography ResinHigh Resolution + High Capacity = Improved YieldPOROS® XS Chromatography ResinHigh Resolution + High Capacity = Improved Yield
resDNASEQ® Host Cell DNA Quantitation System
Same-day results using integrated sample prep, reagents, instruments, and software
Innovations transform bioproduction today
Applied Biosystems® SEQ Analytics POROS® Chromatography Gibco® Cell Culture Cellular Medicine
GMP cellsFriendly IP GMP cells
Friendly IP
Highest resolution +
capacity
Highest resolution +
capacity
Impurity testing in < 5
hours
Impurity testing in < 5
hours
10 04/21/23 | Life Technologies™
Gibco® Bioproduction Services• Gibco® Process Development Team
• Scientific and business development support• Gibco® Program Management Office
• Singlepoint of contact for order management and execution
• Gibco® PD-Direct Services- Cell line development services- Media development and analytical services
• Gibco® Media Express• Gibco® cGMP Media Custom Services
Technical Support and Services
• On-site technical support• POROS® Customs Services• SEQ Validation and Implementation Services• Cell therapy and stem cell services
Bioproduction Online Community• LIFE Bioproduction homepage• Gibco Media Configurator for web quoting, order tracki
ng• Webinars and educational events• Mobile applications
You
Global Support
Working with us
AccountRepresentative
11 04/21/23 | Life Technologies™
Worldwide distribution, service and support reach 150 countries on 6 continents
Bioproduction Manufacturing Sites
Grand Island, NY, United StatesCell culture media, reagents, and sera manufacturing
Auckland, New ZealandSera and protein products manufacturing
Newcastle, AustraliaSera manufacturing
SingaporeSequencing and PCR instrumentmanufacturing
Austin, TX, United StatesPharma analytics kit manufacturing
Paisley, ScotlandCell culture media and reagentsmanufacturing
Christchurch, New ZealandProtein products manufacturing
Bedford, MA, United StatesChromatography resins manufacturing
Warrington, EnglandPharma analytics kit manufacturing
12 04/21/23 | Life Technologies™
bioproduction solutionsfrom molecule to market
Let us take you from molecule to market, so you can take the world from today to tomorrow.
Meet new challenges• Escalating demand for biotherapeutics and vaccines• New cell lines• Heightened concerns about product safety• Emerging biosimilars• Personalized medicine
across multiple therapy classes• Therapeutic protein production• Microbial expression and production• Viral vaccines production• Regenerative medicine• Immunotherapy
using trusted brands• Gibco® cell culture• POROS® chromatography resins• Applied Biosystems® SEQ analytics• Cellular medicine solutions
that set new industry standards• Product quality• Product safety• Fast-to-market efficiency• Dedicated Program Management Office
Meet new challenges• Escalating demand for biotherapeutics and vaccines• New cell lines• Heightened concerns about product safety• Emerging biosimilars• Personalized medicine
across multiple therapy classes• Therapeutic protein production• Microbial expression and production• Viral vaccines production• Regenerative medicine• Immunotherapy
using trusted brands• Gibco® cell culture• POROS® chromatography resins• Applied Biosystems® SEQ analytics• Cellular medicine solutions
that set new industry standards• Product quality• Product safety• Fast-to-market efficiency• Dedicated Program Management Office
Take a molecular leap into the future.
13 04/21/23 | Life Technologies™
Redefining bioproduction tomorrow
• GMP cell line kits• Media and feeds• Sera and reagents• Contaminant and
impurity assays• Chromatography resins• Services
• GMP cell line kits• Media and feeds• Sera and reagents• Contaminant and
impurity assays• Chromatography resins• Services
TomorrowTomorrowTodayToday
• Functional feeds• Segment-specific
products and services (vaccines, biosimilars, CMOs, cell therapy)
• Omics-based profiling
• Affinity, IEX and custom chromatography
• Functional feeds• Segment-specific
products and services (vaccines, biosimilars, CMOs, cell therapy)
• Omics-based profiling
• Affinity, IEX and custom chromatography
• Protein PCR• Bioburden surveillance• Objectionable organism
panels• Environmental
monitoring programs• Next generation
sequencing applications• Closed automated
platform for cell isolation
• Protein PCR• Bioburden surveillance• Objectionable organism
panels• Environmental
monitoring programs• Next generation
sequencing applications• Closed automated
platform for cell isolation
14 04/21/23 | Life Technologies™ 14
1
2
3
45
6
Your partner from molecule to marketFocus on both the journey and the destination
• Cell line development• Expression
development
• Media optimization• Process
optimization
Clinicalmanufacturing
Commercial scale-up and
launch
Global manufacturing
• Cell expansion• Fermentation• Viral expansion
Upstream, downstream and analytical solutions for every
stage of the journey
Upstream, downstream and analytical solutions for every
stage of the journey
15 04/21/23 | Life Technologies™
Freedom™ CHO-S™ cell line kit
Gibco® media and feeds POROS® ChromatographyResins
MicroSEQ™ Microbial Identification System
• Freedom™ CHO cell line kits• Gibco® PD-Direct cell line
development services• POROS® analytical columns• MycoSEQ™ Mycoplasma
Detection System• ViralSEQ® Virus Detection
Assays (MMV, Vesivirus)• MicroSEQ® Microbial
Identification System
• Gibco® media and feeds• Custom cell culture media• Gibco® PD-Direct media
development and analytical services• POROS® analytical columns• GoPure™ disposable columns• MycoSEQ™ Mycoplasma
Detection System• ViralSEQ® Virus Detection Assays
(MMV, Vesivirus, PCV1/PCV2)• MicroSEQ® Microbial
Identification System
• POROS® polish and capture chromatography resins• GoPure™ disposable
columns• resDNASEQ® Host Cell DNA
Quantitation Assays (CHO,NS0)• MicroSEQ® Microbial
Identification System• ProteinSEQ™ Quantitation
Assay (Protein A, HCP)
• MicroSEQ® Microbial Identification System for bacteria and fungi
BIOPRODUCTION SOLUTIONS
NEEDS
• GMP CHO cell lines• Reproducible high titer
• Rapid assays for key contaminants and impurities• Chemically defined, AOF media and matched feeds
• High capacity, high resolution, salt-tolerant resins for polish chromatography
Molecule-to-market solutions supporting mammalian therapeutic protein production
16 04/21/23 | Life Technologies™
POROS® analyticalcolumns
resDNASEQ® Host Cell DNA Quantitation Assays
MicroSEQ® MicrobialIdentification System
• POROS® analytical columns• MicroSEQ® Microbial
Identification System
• Custom media in different formats• POROS® analytical columns• MicroSEQ® Microbial
Identification System
• POROS® chromatography resins• resDNASEQ® Host Cell DNA
Quantitation Assays (e. coli, Pichia)• GoPure™ disposable columns• MicroSEQ® Microbial
Identification System
• MicroSEQ® Microbial Identification System for bacteria and fungi
NEEDS
• Host cell lines• Chemically defined media and vectors• Validated and automated rapid contaminant and impurity tests• High capacity, high resolution, salt-tolerant resins for polish chromatography
Molecule-to-market solutions supporting microbial expression and production
BIOPRODUCTION SOLUTIONS
17 04/21/23 | Life Technologies™
Gibco® media developmentand analytical services
resDNASEQ® Host Cell DNA Quantitation Assays
ViralSEQ® Virus Detection Assays
MicroSEQ® MicrobialIdentification System
• ViralSEQ® Virus Detection Assays (MMV, Vesivirus)• Gibco® PD-Direct
media development and analytical services• MicroSEQ® Microbial
Identification System
• Gibco® media• Custom media in different formats • GoPure™ disposable columns• ViralSEQ® Virus Detection Assays
(MMV, Vesivirus)• Gibco® PD-Direct media
development and analytical services• MicroSEQ® Microbial Identification
System
• POROS® chromatography resins• resDNASEQ® Host Cell DNA
Quantitation Assays (Vero, MDCK)• GoPure™ disposable columns• MicroSEQ® Microbial
Identification System
• MicroSEQ® Microbial Identification System for bacteria and fungi
BIOPRODUCTION SOLUTIONS
NEEDS
• Integrated platform for top human and veterinary vaccine host cells• High cell density, virus titer, and virus stability
Molecule-to-market solutions supportingviral vaccine production
18 04/21/23 | Life Technologies™
MycoSEQ™ MycoplasmaDetectionSystem
Cell therapy andstem cell services
MycoSEQ™ MycoplasmaDetectionSystem
Dynabeads®immunotherapy products
BIOPRODUCTION SOLUTIONS
NEEDS
• Integrated automated platforms• Efficient cell analytics
• Custom solutions• High quality growth
Molecule-to-market solutions supporting cell therapy
• MycoSEQ™ Mycoplasma Detection System• MicroSEQ® Microbial
Identification System
• Dynabeads® lgG1 Binder CTS• DynaMag™ CTS magnet• MycoSEQ™ Mycoplasma
Detection System• Cell therapy and stem cell services• MicroSEQ® Microbial Identification
System
• MycoSEQ™ Mycoplasma Detection System• Dynabeads® CD3/CD28 CTS
•Media, growth factors, buffers and supplements• Cell therapy and stem cell
services• MicroSEQ® Microbial
Identification System
• MycoSEQ™ Mycoplasma Detection System• MicroSEQ® Microbial
Identification System for bacteria and fungi
19 04/21/23 | Life Technologies™
Legal Disclosure
Life Technologies manufactures products labeled for Research Use Only, and for In-Vitro Diagnostic use. Please refer to the Life Technologies website for specific indications and use information for these products.
© 2011 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners.
Life Technologies manufactures products labeled for Research Use Only, and for In-Vitro Diagnostic use. Please refer to the Life Technologies website for specific indications and use information for these products.
© 2011 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners.
20 04/21/23 | Life Technologies™
Appendix
21 04/21/23 | Life Technologies™
Media & feeds Cells• CD CHO*• CD OptiCHO™*• CD FortiCHO™*• CHO CD EfficientFeed™ A• CHO CD EfficientFeed™ B*• CD EfficientFeed™ C AGT• Custom media in different formats
(AGT, DPM, liquid, concentrate)*Also available in proprietary Advanced
Granulation Technology™ (AGT™) format
• Freedom™ Cell Line Development Kits- CHO-S™- CHO-DG 44
• Licensing
Sera Reagents & disposables Bioproduction services• Fetal bovine sera• Horse sera• Rabit sera
• rHu Insulin AOF• Buffers• TryPLE™ Reagents• FoamAway™ anti-foaming agents• Gibco® disposable bags
• Gibco® Process Development Team• Scientific and business development
• Gibco® Program Management Office• Order execution and management
• Gibco® PD-Direct Services• Cell line development services• Media development and analytical
services• Gibco® Media Express• Gibco® cGMP Media Custom Services
“Great all around selection of products, great customer service.”Customer survey, 2011
“Great all around selection of products, great customer service.”Customer survey, 2011
Gibco® products and services
22 04/21/23 | Life Technologies™
Bulk resins Analytical columns Disposable columns
• XS 50 µm Bulk Resin• MabCapture™ A Resin• Heparin 50 µm Bulk Resin• HQ 50 µm Bulk Resin• HS 50 µm Bulk Resin• D 50 µm Bulk Resin• PI 50 µm Bulk Resin• R1 50 µm Bulk Resin• R2 50 µm Bulk Resin
• Protein A 20 µm Columns, PEEK™• Protein G 20 µm Columns, PEEK™• AL 20 µm Columns, PEEK™• EP 20 µm Columns, PEEK™• OH 20 µm Columns, PEEK™• PI 20 µm Columns, PEEK™• HS 20 µm Columns, PEEK™• S 20 µm Columns, PEEK™• MC 20 µm Columns, PEEK™• HP 20 µm Columns, PEEK™• R1 20 µm Columns, PEEK™• R2 20 µm Columns, PEEK™
• GoPure™ 1.2 cm Diameter Column• GoPure™ 8.0 cm Diameter Column• GoPure™ 20 cm Diameter Column
Services• Custom Services
“Their resins can be used at higher flow rates with very good protein binding capacity.”
Customer survey, 2011
“Their resins can be used at higher flow rates with very good protein binding capacity.”
Customer survey, 2011
POROS® products and services
23 04/21/23 | Life Technologies™
Product safety microbiological contaminant analysis
Product quality biologics impurity analysis
Microbial Identification System• MicroSEQ® Rapid Sample Prep• PrepMan® Ultra Sample Prep.
ReagentKits• MicroSEQ® 500 16S rDNA Bacterial
Identification Kit• MicroSEQ® Full Gene 16S rDNA
Bacterial Identification Kit• MicroSEQ® D2 LSU rDNA Fungal
Identification Kit
Instruments• Veriti® 96-Well Thermal Cycler• 3500 Genetic AnalyzerSoftware• MicroSEQ® iD Analysis SoftwareServices• Validation and Implementation
Services
Mycoplasma Detection• MycoSEQ™ Mycoplasma Detection
AssayHost Cell Residual DNA Quantitation• resDNASEQ® Quantitative DNA
System (CHO, NS0, E. coli, Pichia, MDCK, Vero)
Virus Detection• ViralSEQ® Vesivirus Detection
Assay• ViralSEQ® MMV Detection AssayProtein Detection• ProteinSEQ™ Protein Quantitation
Assay
Sample Preparation• PrepSEQ® Mycoplasma Sample
Preparation Kit plus Module M
• PrepSEQ® 1-2-3 Nucleic Acid Extraction Kit
Instruments• 7500 Fast Real-Time PCR System• Automate Express™ Nucleic Acid
Extraction SystemSoftware• AccuSEQ® Real-Time PCR Detection
SoftwareServices• Implementation and Training
Services
“Applied Biosystems® gives the most consistent results, and they have the best technical support for their products”
Customer survey, 2011
“Applied Biosystems® gives the most consistent results, and they have the best technical support for their products”
Customer survey, 2011
Applied Biosystems® SEQ products and services
24 04/21/23 | Life Technologies™
Immunotherapy products Stem cell media and reagents
• AIM V® Medium CTS™• OpTmizer™ CTS™ T-Cell Expansion SFM• Dynabeads® CD3⁄CD28 CTS™• DynaMag™ CTS™• Cell Therapy Systems DPBS CTS™
(without Ca and Mg)• Recombinant human growth factors• Cell therapy and stem cell services
• KnockOut™ CTS™ Media• CELLstart™ CTS™ Reagents• DPBS CTS™ Reagents (with Ca and Mg)• TrypLE™ Select CTS™ Reagents• GlutaMAX™-I CTS™ Reagents• Recombinant human growth factors• Cell therapy and stem cell services
Cellular medicine products and services
25 04/21/23 | Life Technologies™
Best-in-class technology Global technical & sales support
Customer satisfaction State-of-the-art operations
“You can trust this company.”Customer survey, 2011
“You can trust this company.”Customer survey, 2011
“They go all the way to cut red tape and deliver what you need today and not tomorrow .“
“They go all the way to cut red tape and deliver what you need today and not tomorrow .“
Core strengths align with customer needs
Top Related