BIOTECHNOLOGY
&
BIOCHEMICAL ENGG.
COMPILED Notes
For Indian students
The current task of biochemical
engineering research and development
is to integrate and develop the new
tools for the industrial applications. The
borders between the traditional
activities in bioprocessing, often called
upstream, reaction and downstream
processing, respectively, are becoming
more and more diffuse due to these
developments.
PERIODS OF BIOPROCESSES
• Pre-1800: Early applications & speculation
• 1800-1900: Significant advances in basic
understanding of biosciences
• 1900-1953: Genetics
• 1953-1976: DNA research, science knowledge
explodes
• 1977 – present modern technology
Penicillin – Sorona –
High – Fructose corn syrup
•
TEXT BOOKS.
1. M.L. Shuler and F. Kargi," Bio-process Engineering", 2nd Ed.,
Prentice Hall of India, N. Delhi, 2005
2 J.E. Bailey and D.F. Ollis," Biochemical Engineering Fundamentals",
2nd Edn., McGraw Hill, Publishing Co. New York., 1985.
3. P. Stanbury, A. Whitaker and S. J. Hall "Principles of Fermentation
Technology" 2nd Edn., Aditya Books (P) Ltd, N. Delhi.1997.
4. Biochemical Reaction Engineering, R. Lovitt and M. Jones, Chapter 5
in Chemical Engineering Vol 3, (third Edition), Richardson and Peacock,
1994, Asian Books (pvt) Ltd, N. Delhi.
5. Bioprocess Engineering: Systems Equipment and Facilities, Edited
by B.K.Lederson, N.A.D’elia and K.L.Nelson (1994), John Wiley and
Sons, N.Y.
Additional useful Reference books: Biosciences:
1. Fundamentals of biochemistry by J. L. Jain, S. Jain
and N. Jain [6th Ed.] S. Chand & Co, N. Delhi
2. Textbook of Biochemistry [Fourth Ed.], by Staunton-
Todd – Mason –Bruggen, Oxford & IBH Publishing Co
(Pvt) Ltd. N. Delhi.
3. Molecular Biology (Second Ed.) by David Freifelder,
Narosa Publishing House, N. Delhi.
Fundamentals of Biochemical Engineering, Rajiv Dutta,
2008, Springer, Ane Books India
Additional useful Reference books:
Biochemical Engineering:
1. Chemical Reaction Engineering, O. Levenspiel, Third Ed.
Part V, Biochemical Reaction Systems, pages 609 – 654,
chapters 27 to 30. Enzyme fermentation, Microbial
Fermentation, Substrate limiting fermentation, Product
limiting microbial limitation.
2. Biochemical Engineering, by Gummadi, Sathyanarayana
N. and Doble, Mukesh, Published by P H I, N. Delhi.
3. Biochemical Engineering: Principles and Concepts by
Inamdar and Syed Tanveer Ahamed. Published by P H I,
2007 New Delhi.
Bioprocess Engineering Principles, by Pauline M. Doran, 1995,
Elsevier Science & Technology Books
The primary aim of this book is to present the principles of bioprocess
engineering in a way that is accessible to biological scientists. It does not
seek to make biologists into bioprocess engineers, but to expose them to
engineering concepts and ways of thinking.
The chapters are organized around broad engineering sub-disciplines
such as mass and energy balances, fluid dynamics, transport phenomena
and reaction theory, rather than around particular applications of
bioprocessing. That the same fundamental engineering principle can be
readily applied to a variety of bioprocess industries is illustrated in the
worked examples and problems.
Govt. Depts. Supporting research in biotechnology in India
Over the years India has developed strengths in
biotechnology in public sector institutions. The graduation
from Biotechnology Development Board to Department of
Biotechnology in late eighties was a decisive step to
address a wider canvas in biotechnology. In these years
DBT has emerged as a major force to direct biotechnology
developments in India. Further, the involvement of various
agencies dealing with this technology has further helped
in developing technology capability at various levels. The
size of the industry is estimated to have grown to $1.5 to
$2.5billion between 1999 and 2002.
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