For pathway key and background please visit:
www.cellsignal.com/bcell
B Cell Receptor Signaling
IP3R
IntracellularCa2+ Store
Ca2+
CREBMEF2C
p38
p38 JNK1/2
MKK3/4/6 MKK4/7
Lyn
Akt
PTEN
SHIP
Akt
FoxO
mTORGSK-3
IκBNFAT
p70S6K
LynSyk
Btk
SHP-2
PLCγ2
GabShc
GRB2
GR
B2
BLN
K
PKC
JNK Erk1/2
Erk1/2
MEK1/2
c-Raf
Ras
NF-κB
NF-κBIκB
IKK
PKC
CaMK
ATF-2 Jun Egr-1 Elk-1 Bcl-xL Bfl-1 NFAT
CD19
CD19
CD19
CD45
CaM
Bam32
CIN85
MEKKs
SOS
RasGAP
RasGRP
Bcl-6 Oct-2 Ets-1
CD40
LAB
LAB
CblCsk
Cbp/PAG
SHP-1BCAP
CARMA1
Ag
CD22 FcγRIIB1
FcγRIIB1
Bcl10
RhoA
Rap
Rac/cdc42
Rac
RapLRiam
Cofilin
Pyk2
HS1
Dok-1
Dok-3
CD19
PIR-B
Ezrin
Bam32
clathrin
TAK1
Calcineurin
CR
AC
Cha
nnel
Ora
i1
Ca2+
STIM1
SHP-2SHP-1
MALT1
GRB2 Vav
BCR
p85PI3Kp110
ProteasomalDegradation
ProteinSynthesis
Transcription
Growth Arrest,Apoptosis
DAGCa2+
Ca2+
PIP3
Transcription
mIgα/β α/β mIg
PI(4,5)P2
CytoskeletalRearrangements and
Integrin Activation
DAG
DAG
PIP3
IP3
LipidRaft
AggregationBCR
Internalization
Transmembrane Protein
Glucose Uptake
Glycolysis
ATPGeneration
Nucleus
Cytoplasm
www.cellsignal.com/cellbiologyFor Research Use Only. Not For Use In Diagnostic Procedures.
www.cellsignal.com/cellbiologyFor pathway key and background please visit:
APPLICATIONS & REACTIVITY KEY: WB Western Blotting / IP Immunoprecipitation / IHC Immunohistochemistry / IF Immunofluorescence / F Flow Cytometry / ChIP Chromatin Immunoprecipitation / -IC Immunocytochemistry / -P Paraffin / -F Frozen / E-P Peptide ELISA / H human / M mouse / R rat / Hm hamster / Mk monkey / C chicken / Mi mink / Dm D. melanogaster / X Xenopus / Z zebrafish / B bovine / Dg dog / Pg pig / Sc S. cerevisiae / All all species expected / ( ) 100% sequence homology
17IM
M14
7PW
H1E1
www.cellsignal.com/bcell
ANTIBODIES APPLICATIONS REACTIVITY
#15103 Aiolos (D1C1E) Rabbit mAb WB, IP, IHC-P, F, ChIP
H, M
#14895 BCL6 (D4I2V) XP® Rabbit mAb WB, IP, IF-IC, F, ChIP
H
#4237 Bcl10 (C78F1) Rabbit mAb WB, IP H, M, R, (Mk)
#2764 Bcl-xL (54H6) Rabbit mAb WB, IP, IHC-P, IHC-F, IF-IC, F
H, M, R, Mk
#9115 Blimp-1/PRDI-BF1 (C14A4) Rabbit mAb WB, IP, IF-IC H, M, (Mk)
#36438 BLNK (D3P2H) XP® Rabbit mAb WB, IP, IHC-P, F H, M
#3601 Phospho-BLNK (Tyr96) Antibody WB, IP H
#56044 Btk (D6T2C) Mouse mAb WB, IP, F H, M
#5082 Phospho-Btk (Tyr223) Antibody WB H, (M), (R)
#3574 CD19 Antibody WB, IP, IF-IC, F H, M
#3571 Phospho-CD19 (Tyr531) Antibody WB, IP H
#13917 CD45 (D9M8I) XP® Rabbit mAb WB, IP, IHC-P, IF-IC, F
H
#13333 CD79A (D1X5C) XP® Rabbit mAb WB, IHC-P, F H
#96024 CD79B (D7V2F) Rabbit mAb WB, IP, IHC-P H,M
#14732 Phospho-CD79A (Tyr182) (D1B9) Rabbit mAb IF-IC, F H, (M)
#5175 Cofilin (D3F9) XP® Rabbit mAb WB, IF-IC H, M, R, Mk, Dg
#3313 Phospho-Cofilin (Ser3) (77G2) Rabbit mAb WB, IF-IC H, M, R, Mk, B
#3145 Ezrin Antibody WB, IP, IHC-P, IF-IC, F
H, M, R, Mk, B
#3726 Phospho-Ezrin (Thr567)/Radixin (Thr564)/ Moesin (Thr558) (48G2) Rabbit mAb
WB, IHC-P, IF-IC, E-P
H, M, R, Mk, (B)
#3890 HS1 (D83A8) XP® Rabbit mAb (Human Specific) WB, IP, IHC-P, IF-IC, F
H
#8714 Phospho-HS1 (Tyr397) (D12C1) XP® Rabbit mAb WB, IF-IC, F H, (M), (R)
#14859 Ikaros (D6N9Y) Rabbit mAb WB, IHC-P, IF-IC, F, ChIP, ChIP-seq
H, M
#9034 Ikaros (D10E5) Rabbit mAb WB, IF-IC, F, ChIP H
#15106 IRF-4 (D9P5H) Rabbit mAb WB, IP, ChIP H, M, R
#4299 IRF-4 (D43H10) Rabbit mAb WB, IP, ChIP H, R
#2796 Lyn (C13F9) Rabbit mAb WB, IP, IHC-P H, M, R, Mk
#2731 Phospho-Lyn (Tyr507) Antibody WB H, M, (R)
ANTIBODIES APPLICATIONS REACTIVITY
#8690 p38 MAPK (D13E1) XP® Rabbit mAb WB, IHC-P, IF-IC, F H, M, R, Hm, Mk, B, Pg, (C)
#9212 p38 MAPK Antibody WB, IHC-P, IF-IC, F H, M, R, Mk, GP, (C)
#4511 Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP® Rabbit mAb
WB, IP, IHC-P, IF-IC, F
H, M, R, Mk, Mi, Pg, Sc, (Hm), (C), (Z), (B), (Pg)
#9215 Phospho-p38 MAPK (Thr180/Tyr182) (3D7) Rabbit mAb
WB, IF-IC, F H, M, R, Mk, Dm, Pg, Sc, (Hm), (Mi), (Z), (B)
#4631 Phospho-p38 MAPK (Thr180/Tyr182) (12F8) Rabbit mAb
WB, IHC-P, IF-IC H, M, R, Mk, Dm, (Hm), (Mi), (Z), (Hr)
#9216 Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb
WB, IP, IF-IC, F H, M, R, Mk, Sc, (Z)
#5861 NFAT1 (D43B1) XP® Rabbit mAb WB, IP, IHC-P, IF-IC, F
H, M
#3872 PLCγ2 Antibody WB, IP H, M, (R)
#3871 Phospho-PLCγ2 (Tyr1217) Antibody WB H, M, (R)
#9427 Phospho-c-Raf (Ser338) (56A6) Rabbit mAb WB H, M, R, Mk
#8955 Ras (D2C1) Rabbit mAb WB H, M, R, Mk
#3339 Ras (27H5) Rabbit mAb WB H, M, R, Mk, Dm
#2117 RhoA (67B9) Rabbit mAb WB H, M, R, Mk, B
#2727 SHIP1 (C40G9) Rabbit mAb WB, IP, IF-IC, F H
#2839 SHIP2 (C76A7) Rabbit mAb WB, IP, IF-IC, F H
#3759 SHP-1 (C14H6) Rabbit mAb WB H, M, (R)
#8849 Phospho-SHP-1 (Tyr564) (D11G5) Rabbit mAb WB H, M
#3397 SHP-2 (D50F2) Rabbit mAb WB, IP H, M, R, Mk
#5431 Phospho-SHP-2 (Tyr580) (D66F10) Rabbit mAb WB, IP, F M, R, (H)
#2109 Src (36D10) Rabbit mAb WB, IP, IHC-P, IF-F, IF-IC, F
H, M, R, Hm, Mk, B, Pg, (C)
#6943 Phospho-Src Family (Tyr416) (D49G4) Rabbit mAb
WB, IP H, M, R, Mk
#2101 Phospho-Src Family (Tyr416) Antibody WB H, M, R, (C), (X)
#5668 STIM1 (D88E10) Rabbit mAb WB, IP, IF-IC H, M, R, Mk, B
#13198 Syk (D3Z1E) XP® Rabbit mAb WB, IP, IHC-P, F H, M, R
#2710 Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb WB, IP, IF-IC, F H, (M), (R)
© 2017 Cell Signaling Technology, Inc. All rights reserved. Cell Signaling Technology, and CST are trademarks of Cell Signaling Technology, Inc. U.S. Patent No. 5,675,063. All other trademarks are the property of their respective owners.
Key Products for B Cell Receptor SignalingVisit www.cellsignal.com/bcellproducts for full listing of antibodies, related kits, and reagents.
Serum-starved IgM-treated
Phospho-Syk (Tyr525/526) (C87C1) Rabbit mAb #2710: Confocal IF analysis of Ramos cells, serum-starved (overnight; left) or IgM-treated (12 ug/ml, 2 min; right), using #2710 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).
Syk (D3Z1E) XP® Rabbit mAb #13198: IHC analysis of paraffin-embedded human lymph node using #13198.
BLNK (D3P2H) XP® Rabbit mAb #36438: IHC analysis of paraffin- embedded human tonsil using #36438.
For Research Use only. Not For Use In Diagnostic Procedures.
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