Einladung zum VO R T R A G
Gesellschaft Österreichischer Chemiker
Institut für Organische Chemie
“NMR in drug discovery. The power of resolution.”
Dr. Andras BoeszoermenyiHarvard Medical School Boston, USA
Dienstag, 07. Mai 2019, 16:00 Uhr.
HS H, „Ulrich Santner“ NTEG230E
Technische Universität Graz
Kopernikusgasse 24, Erdgeschoß
Nuclear Magnetic Resonance (NMR) spectroscopy is a highly versatile technique to monitor function, structure and dynamics
of biomolecules. Its unique ability to directly observe nuclei in solution, enables the simultaneous monitoring of hundreds of
probes in biomolecules (the nuclei) as they respond to environmental queues (e.g. ligand binding, conformational changes,
immersion into a membrane environment, or changes in dynamics). I will discuss (i) how we used NMR spectroscopy to
elucidate the mechanism of T-cell receptor signaling [1], (ii) the re-discovery of fluorine in biomolecular NMR and its
implications [2], and (iii) how NMR studies of transcription factor / co-activator complexes drive drug discovery projects [3].
[1] Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS,
Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL, Immunity 2018, 49, 829-841.
[2] Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C,
Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H,
Nature Methods 2019, 16, 333-340
[3] Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M,
Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H, Nature 2016,
530,485-489.
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