What’s New In Cancer Care
Michael Vander Kooy, MD
Radiation Oncologist
Agnesian Cancer Center
Know & Go Friday. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Michael Jones, MD
Medical Oncologist
Agnesian Cancer Center
Advances In Radiation OncologyMichael Vander Kooy, MD
Radiation OncologistAgnesian Cancer Center
Radiation Oncology
Michael Vander Kooy, MD Filip Troicki, MD Timothy Korytko, MD
Radiation Therapy
Noelle B., RTT Ellie B., RTT Bonnie D., RTT
Radiation Therapy
Brian S., RTT Angie H., RN
Radiation Nursing
Tammie L., RN Mary L., RNStacy S., RN
Ancillary Associates
Tim L.Physicist
Phil B.Dosimetrist
Heather B., Oncology Supervisor
Ancillary Associates
Chris B.Oncology Navigator
Liz H., RDDietitian
Kristie M., MSW Social Worker
Agnesian Cancer Center
Linear Accelerator
THANK YOU!
Advances In Medical OncologyMichael Jones, MDMedical Oncologist
Agnesian Cancer Center
Medical Oncology
Joel Lundberg, MD Michael Jones, MD
Sara S., LPN Betsy M., LPN Rachel S., RN
Medical Oncology
Nicki W., RN Margot B., RN Terri B., RN
Medical Oncology
Kristin M., RN Cindy K., RN
Medical Oncology
Patty S.Pharmacy Technician
Travis D., PharmD, RPh
Medical Oncology
General Outline
What is cancer
Cancer heterogeneity and implications for
treatment
General cancer treatments.
Targeted cancer therapyThe Story of BCR-ABL and chronic
myelogenous leukemia.
BRAF and melanoma.
What Is Cancer?
What Has Happened?
Cancer Is a Genetic DiseaseCancer is a genetic disease that develops in a
predictable sequence of steps
Carcinogenesis Transformation of a normal cell into a cancerous cell
Occurs by a step-by-step transformation
Involves an abnormal change in cell DNA called a
mutation.
These mutations facilitate the cell to divide, invade,
and metastasize independent of normal cell
controls.
Cancer Often Involves Multiple Mutations
Multiple Mutations Influence Cancer Cells Survival
Carcinogenesis Occurs In Predictable Steps
Cancer Heterogeneity and Implications
for Treatment
How is Cancer Heterogeneous?
We Are Just Beginning to Understand
General Cancer Treatments
How Does An Oncologist Treat Cancer?
Chemotherapy
Radiation Therapy
Immunotherapy
Targeted Therapy
Targeted Cancer Therapy
Targeted Cancer Therapy
Identifying specific gene abnormalities which facilitate or allow cancer to grow and divide, and “targets” that abnormality with a specific drug.
“Dumb Cancer”- Cancer has developed just a few mutations which are vital to the cancer cell’s survival.
“Smart Cancer”- Cancer has developed multiple mutations which facilitate its growth. Each is important but not necessarily vital to cancer cell survival.
Targeted Cancer TherapyThe Story of BCR-ABL and
Chronic Myelogenous Leukemia
Chronic Myelogenous LeukemiaA Simple Cancer
Normal blood smear Leukemia blood smear
Translocation of DNA in Chromosome
Variations in Chromosomal Deletions Patterns in Patients with Glioblastoma Brain Tumor
p53locus
Chromosomal Loss:
PTENlocus
CDKN2locus
RB1locus
Chronic Myelogenous Leukemia
Normal blood smearLeukemia blood smear
Translocation of DNA in Chromosome
Imatinib (Gleevac) in Chronic Myelogenous Leukemia
Impact of Treatment on Patients Lives Treated with Gleevac
Targeted Cancer TherapyMelanoma & BRAF
Melanoma
Mutational Frequency In Melanoma
Hodis, Cell 2012
How BRAF Works in Melanoma
Drug Targeting BRAF
14-Day Response to Vemurafenib
Effects of Vemurafenib On Survival in Metastatic Melanoma
THANK YOU!
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