Age Female

Non-white Married

College or higher education Annual income ≥ $25,000

Current smoker Smoking, pack years

Alcohol, drinks per weekWalked blocks last week

15 feet walk timeBody mass index

Self-reported fair to poor health Basic activities of daily living

Instrumental activities of daily livingCoronary artery disease

Acute myocardial infarctionCoronary bypass surgery

Angina pectoris Coronary angioplasty

Hypertension Diabetes mellitus

Stroke Chronic obstructive pulmonary disease

Lung capacity

Absolute standardized difference (%)

Supplementary Figure 1. Absolute standardized differences comparing 50 baseline characteristics between Cardiovascular Health Study (CHS) participants with chronic kidney disease (CKD) stage 3A (eGFR 45-59

ml/min/1.73 m2) versus without CKD (eGFR ≥ 60 ml/min/1.73 m2), before and after propensity score matching

CancerArthritis

PulseSystolic blood pressure

Diastolic blood pressure Ankle arm index

Fasting plasma glucose Serum uric acid

Serum potassium Serum triglyceride Serum cholesterol

Serum low density lipoproteinSerum high density lipoprotein,

Serum albuminSerum fibrinogen

Serum insulinSerum C-reactive protein

Serum interlukin-6Serum factor VII

HemoglobinWhite blood cells

Platelets Atrial fibrillation

Left ventricular hypertrophy Left ventricular systolic dysfunction

Absolute standardized difference (%)

Age Female

Non-white Married

College or higher education Annual income ≥ $25,000

Current smoker Smoking, pack years

Alcohol, drinks per weekWalked blocks last week

15 feet walk timeBody mass index

Self-reported fair to poor health Basic activities of daily living

Instrumental activities of daily livingCoronary artery disease

Acute myocardial infarctionCoronary bypass surgery

Angina pectoris Coronary angioplasty

Hypertension Diabetes mellitus

Stroke Chronic obstructive pulmonary disease

Lung capacity

CancerArthritis

PulseSystolic blood pressure

Diastolic blood pressure Ankle arm index

Fasting plasma glucose Serum uric acid

Serum potassium Serum triglyceride Serum cholesterol

Serum low density lipoproteinSerum high density lipoprotein,

Serum albuminSerum fibrinogen

Serum insulinSerum C-reactive protein

Serum interlukin-6Serum factor VII

HemoglobinWhite blood cells

Platelets Atrial fibrillation

Left ventricular hypertrophy Left ventricular systolic dysfunction

Supplement Figure 2. Absolute standardized differences comparing 50 baseline characteristics between Cardiovascular Health Study (CHS) participants with chronic kidney disease (CKD) stage ≥3B (eGFR<45 ml/min/1.73 m2) versus no-CKD (eGFR ≥ 60 ml/min/1.73 m2), before and after propensity score matching