A Green Chemistry Company
Impact of Green Chemistry
@
Manufacturing
We shall require a substantially new manner of thinking if mankind is to
survive.
Transforming industrial manufacturing through green chemistry
~ ecoLogic’s mission statement
Green Chemistry at a glance
4
Green chemistry is the design, development, and
implementation of chemical products and processes
to reduce or eliminate the use and generation of
substances hazardous to human health and the
environment.
E-Factor Intensity Metric
5
Can we produce pharmaceutical intermediates with E-factors matching with Bulk
chemicals?
The Twelve Principles
1. Prevent waste
2. Atom Economy
3. Less Hazardous Chemical Syntheses
4. Designing Safer Chemicals
5. Safer Solvents and Auxiliaries
6. Design for Energy Efficiency
7. Use of Renewable Feedstocks
8. Reduce Derivatives
9. Catalysis
10. Design for Degradation
11. Real-time analysis for Pollution Prevention
12. Inherently Safer Chemistry for Accident Prevention
*Anastas, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, Oxford University Press: New York, 1998, p.30. By
permission of Oxford University Press
E-Factor Intensity Metric
Current Members
Amgen
AstraZeneca
Boehringer-Ingelheim
Bristol-Myers Squibb
Eli Lilly and Company
GlaxoSmithKline
Johnson & Johnson
Merck & Co., Inc.
Novartis
Pfizer Inc.
Roche
Sanofi
ACS Green Chemistry
Institute®
Associate Members
Codexis
Dr. Reddy’s
DSM Pharmaceutical Products
A Green Chemistry Company, Established in Year 2009
By a team of technocrats having decades of experience in chemical and
pharmaceutical industry, with an aim to create processes and strategies
wherein, from conception to manufacture and beyond, the use of resources
and energy is optimized and the end product is created with the least
possible impact on the environment .
About ecoLogic
Approaches for better E-factor
9
• Conceptual
• Atom economy
• Reduce protection/deprotection
• Avoid using derivatives
• Establishing catalytic cycle
• Using catalysts
• Practical optimization
• Improve yields – close to theoretical
• Reduce solvent volumes/improve recovery
• Reagents at molar eq. scale
• Avoid neutralizations, washings etc.
• Recovery and reusability of materials
Photo-Bromination Technology
10
• Traditionally NBS/DBDMH used (low atom economy!)
• Benzylic bromination under photochemical conditions
• Only one equivalent of HBr will be consumed
• Water is the only by-product
• Practiced on ton scale per batch
• Capacity of 30-40 tons per month
• E-factor 3.5
Example of oxidation reaction
11
• Avoided Mn, Cr based reagents
• General oxidation reaction
• HBr is catalytic and actual oxidant is hydrogen peroxide
• The only by-product is water
• Light enhances the rate of the reaction
• Performed on multiple hundred kilogram scale per batch
• Running at 20-30 tons per month capacity
• E-factor 3.6
Technology for etherification
12
• Technology to remove water continuously from reaction mass
• Almost solvent-free transformation – close to mol eq. of methanol
• The reactant is being used as solvent at reaction temperature
• Catalytic amount of sulfuring acid
• Performed on ton scale batch size
• Capacity ~30 tons per month
• E-factor = 0.5
Solvent Free Synthesis
13
• First Solvent-free reaction at ecoLogic
• Practiced in plant on multiple hundred kilo batch sizes
• Achieved a capacity of 15 tons/month
• The by-product is recovered and reused in the next stage as a base
Dr Pratik Patel & team
Mr Srinivasa Reddy & team
and
leadership team @ ecoLogic
14
Acknowledgements
Development Centre
Plot No. 56 Road No. 5 ALEAP Industrial Area Pragathi Nagar Kukatpally Hyderabad . Phone : 040-65813842
Manufacturing Facility
Plot Nos. 5/1, 5/2, 5/3,5/4 APIIC, Pydibheemavaram Mandal - Ranasthalam Dist,Srikakulam—532 409 Phone : 08942-220002
Corp Office
Plot No. 143
Road No. 13
Banjara Hills
Hyderabad
Phone: 040-42024371
E-mail: [email protected]
www.ecologitech.co.in
Top Related