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SPONTANEOUS PRETERM BIRTH
Intra-amnioticinfection
Multiplefactors
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MMP families
Interstitialcollagenases (MMP-1
and MMP-8)
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MMP-1 and MMP-8
degrade fibrillar collagen types I and III
spontaneous preterm birth ?
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determine whether matrix
metalloproteinase-8, which isproduced by neutrophils, is a useful
marker for the detection of intra-amniotic infection
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Study designcase-control study using enzyme-linked immunosorbent assays to
detect matrix metalloproteinase-8
PlaceUniversity of Pennsylvania, theUniversityof Florida, and Yale University
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Thirty women had culture-provenintra-amniotic infection (cases)
21 of whom had intact membranes
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Table I. Demographic characteristics
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ROC for optimalthreshold
MMP-8 in 27 of 30 women with intra-
amniotic infection
MMP-8 in 10 of 47 control specimens (P