58ES

PE

Poster presented at:

Diagnostic value of random serum growth hormone, IGF-I and IGFBP-3

concentrations for the diagnosis of growth hormone deficiency in

patients below one year of life.

P1- 72

Design: Diagnostic validation study at a tertiary hospital.• Random serum samples.

• GH (IRS 98/574), IGF-I (WHO 02/254) and IGFBP-3

(Siemens, IMMULITE 2000/Xpi); CV% < 5%

• IGF-I was log-transformed

• Statistics: Multiple regression analysis, Kruskal-Wallis,

Fisher t Test; Receiver operating curve (ROC):

GHD (true positive) versus TH (true negative)

• Primary main outcomes: GH SDS, IGF-I SDS, IGFBP-3

SDS.

• Measures by ROC: Diagnostic accuracy (DA), Area

under the curve (AUC), Sensitivity (S), Specificity (Sp),

Positive and Negative Predictive Value (PPV and NPV).

1- To establish reference intervals for serum concentration of GH,

IGF-I and IGFBP-3 for the whole first year of age.

2- To investigate GH, IGF-I and IGFBP-3 usefulness for GHD

diagnosis in neonates and early infancy.

PatientsInclusion criteria: Infants 1m

** **

*

* p< 0.01 vs. 31-60 d

p< 0.01 vs. girls

+++

+ p< 0.001 vs. 2-6 m

++ p< 0.001 vs. 31-60 d

Neonates Neonates

Age

ug

/L

1º w

2º w

3º w

4º w

1st m

2-6

m

7-12

m1º

w2º

w3º

w4º

w

1st m

2-6

m

7-12

m

0

15

30

45

60

75

90

*****

+++++

*** p< 0.0001 vs. 2º-4º w

** p< 0.001 vs. > 1m

++ p< 0.01 vs. 2-6 m

+++ p< 0.0001 vs. 2º w to 2 m and vs. 7-12 m

p< 0.01 vs. 3º w girls

p< 0.01 vs. 2-6 m girls

Neonates Neonates

Age

ug

/L

1º w

2º w

3º w

4º w

31-6

0 d

2-6

m

7-12

m1º

w2º

w3º

w4º

w

1st m

2-6

m

7-12

m

0

1

2

3

4

***

***** p< 0.0001 vs. > 2º w

** p< 0.01 vs. > 2m

+++

++ p< 0.01 vs. 3º w

+++ p< 0.0001 vs. > 2º w

p< 0.01 vs. 4º w or 2-6 m ingirls

p< 0.01 vs. 3º w in girls

Neonates Neonates

Age

ug

/L

-2

0

2

4

Cut-off: -1.0 SDS

*** p< 0.0001 GHD vs TH and HI

***

SD

S

P1-072María Gabriela Ballerini DOI: 10.3252/pso.eu.58ESPE.2019

GH and IGFs

Número de diapositiva 1