Zika Virus Dr. Harman

7/24/2019 Zika Virus Dr. Harman

1/24

ZIKAVIRUS

Presented By: Dr. Harman Multani

Moderated By: Dr. Varsha A Singh


2/24

I!R"DU#!I"

Rhesus Monkey- 1948 inUganda , Africa.

Humans - 1968 in Nigeria, Africa


3/24

GLOBAL RISK

2007 - Yap I!and,"icr#neia

Prior 2015 - O$%&rea' in par% #f Africa ,S#$%(ea%Aia and %(e )aci*c I!and

May 2015 +ir% #$%&rea' in Brai!

21 October 2015 1 dea%( in %(e /#r!d.

1. 0i!!i#n cae6 dea%( fr#0 0icr#cep(a!2 in Brai!

Since November - 4,333 cae #f 0icr#cep(a!2in &a&ie infec%ed 0#%(er.


4/24


5/24

IRUS 5LASSI+I5AION

Arthroo! borne "irus #rou$Gr#$p I77RNA %ami&y$ +!a:i:iridae #enus$ +!a:i:ir$ Secies$;i'a :ir$


6/24


7/24

IRUS SRU5UR< = 5O")OSIION

Mature virions '(0 nm) Nuc&eocasi! '25-*0 nm)

+ii! ,i&ayer ith enve&oe! . an! Mroteins

ssRNA /cosahe!ra& symmetry


8/24


9/24


10/24

PR$#URS"R M$MBRA$ PR"!$I %&rM'


11/24

large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*large( highly)*onser+ed &roteinssmaller(hydro&ho,i*smaller( hydro&ho,i* &roteinssmaller( hydro&ho,i* &roteinsSmaller(hydro&ho,i*


12/24

R.PRO3/". 4+. /N HOS3 .++


13/24

!he re&rodu*ti+e *y*le same as other -non /la+i+iruses.

Virion -en+elo&e &rotein

endocytosis.

fuses with the endosomal membrane

ssRNA genome released- cytoplasm

translated - structural and non-structural proteins.

01 #R - RNA packaging, cyclization, genome stabilization, andrecognition

21 #R )translation ( methylated nucleotide cap or a genome- linkedprotein


14/24

Assembly- endoplasmic reiticulum

new !irions - "olgi apparatus

release

new !irions can infect new host cells.


15/24


16/24

PA3HO#.N.S/S O% /6A"/RS


17/24

)ri0ar2 >#%I)?- @a2

IiiIinInfec%i#ni

Spread

RRep!ica%i#n


18/24

SIGNS AN@ SY")O"S

"i!d and !a% f#r - da2. >eadac(e

+e:er

S'in ra(e 7ean%(e0a )in' e2e

5#n$nc%i:i%i

"$c!e and #in% pain

"a!aie


19/24

N


20/24

/A#NOS/S O% /6A "/RS

Sam&e$B!##d, Sa!i:a, Urine.

PR$ Uef$! in *r% C- da2 af%er %(e

#ne%.@irec% de%ec%i#n #f RNA #r peci*c

:ira! an%igen in c!inica! peci0en.

Sero&o8y 3est$ @e%ec% %(e preence #fan%idie $ef$! #n!2 af%er

da2.


21/24

!R$A!M$! "6 ZIKA VIRUS

#here is no specific treatment or !accine currently a!ailable.

America has !7"potential $ika !accines ready for human

trials - but officials admit they won%t be in use for %se!eralyears%

#he Bharat Biote*h International 3imited in &yderabad

say they ha!e de!eloped the world%s first !accine against the$ikaVirus. ('rishna lla, chairman and managing director
http://www.ndtv.com/topic/Zika-Virushttp://www.ndtv.com/topic/Zika-Virushttp://www.ndtv.com/topic/Zika-Virushttp://www.ndtv.com/topic/Zika-Virus


22/24


23/24

PR$V$!I" AD #"!R"3 "6 ZIKA VIRUS

A!oid tra!el to areas with an acti!e infestation.

#ra!elers should take the basic precautions to protect themsel!es

from mos)uito bites.

*uring outbreaks, health authorities may ad!ise that spraying of

insecticides be carried out.

Reducing mos)uito populations and a!oiding bites, which occurmainly during the day.

liminating and controllingAedes aegyptimos)uito breeding sites

reduces the chances that $ika will be transmitted.


24/24

!HAK

4"U

Zika Virus Dr. Harman

Documents

Transcript of Zika Virus Dr. Harman