YOUR MICROBIOLOGICAL PROCESS OPTIMISED
Transcript of YOUR MICROBIOLOGICAL PROCESS OPTIMISED
YOUR MICROBIOLOGICAL PROCESS OPTIMISED
MICROBIAL STRAIN IMPROVEMENT, GENETICS AND
PHYSIOLOGY
At NIZO, we employ a wide range of tools that allow for selec-
tion and optimisation of strains, and identification of the ideal
fermentation conditions. We can assist you in increasing
protein production, improving robustness, increasing shelf-life
stability, development of new fermented dairy and non-dairy
products or improving food safety. Our MICRO-platform allows
for high throughput in-product analysis of your process.
These combined capabilities have resulted in new products
and significant cost reduction for many microbiological pro-
cesses of our customers.
Meeting the demands of current health trends, globalisation
and product diversification requires controlled, rational,
and innovative application of microorganisms in pharma
and food. NIZO’s fermentation expertise focuses on the
optimisation of these industrial processes.
We have a team of over 30 experts in bacterial genetics,
physiology and related disciplines and state of the art
infrastructure to deal with complex questions, and to
analyse and interpret big datasets. We can help you design
robust and cost efficient microbial processes.
“The fermentation group of NIZO food research is a valuable innovation partner for CSK food enrichment. Anchored in a
strong heritage of applied dairy research, the fermentation group offers state-of-the-art research methods to study lactic
acid bacteria and their properties. If you are willing to pay a price for quality, you will find in NIZO a trusted partner”, says Wilco Meijer - Director R&D – CSK food enrichment CV.
NIZOKernhemseweg 2, 6718 ZB Ede
P.O. Box 20, 6710 BA Ede, The Netherlands
www.nizo.com
ABOUT US: The growing world population needs better food: healthier, tastier, more affordable and produced more sustainably.
We know better food is essential for better health. Our passion is accelerating innovations together with our customers, applying
our combined expertise in bacteria, proteins and processing. Together we deliver sustainable solutions for better food and health.
NIZO is world leading in the engineering of lactic acid bacteria,
be it through natural or DNA modifying techniques. Our
culture collection is an excellent source for new production
organisms and in combination with our high throughput
screening and -omics platforms we are able to identify
strains of interest and optimise the conditions for the
eventual application. Screening thousands of conditions for
e.g. growth characteristics, enzyme activities and metabo-
lites can be followed up by up-scaling of the process in the
laboratory (up to 30 litre fermenters) and in our pilot plant
(up to 3000 litre fermenters).
TECHNOLOGIES TO OPTIMISE YOUR MICROBIOLOGICAL PROCESS
02/19/007
“With our research we have been able to help many costumers to improve their processes
and I am convinced that new technological possibilities will allow further optimisations”, says Dr. Herwig Bachmann, Expertise group leader Fermentation.
For more information, please contact Dr. Herwig Bachmann.
By phone: +31 318 659 652 or by e-mail: [email protected]
DATA MINING
• Strain selection
• Medium design
• Parameter selection
HIGH THROUGHPUT
SCREENING
• Process Conversion
to Micro-Model
• In product screening
OPTIMISATION
• Optimal yield
• Highest robustness
• Increased Metablite
Production
UPSCALING
AND PRODUCTION
� Selecting probiotics: Nat Rev Microbiol 2011
Nov 21;10(1):66-78
� Optimisation of biomass yield: PNAS 2013
Aug 27;110(35):14302-7
� LAB genetics: Microb Cell Fact. 2014 Nov 4;13:148.
� ®MICRO-Platform – example of in-product screening:
J Dairy Sci 2009 Dec;92(12):5868-82
� NICE™ protein overexpression system: Appl Microbiol
Biotechnol 2005 Oct;68(6):705-17
� More than 470 PubMed cited publications