Your Global Partner for Manufacturing, Packaging and R&D ... · HPMC Capsule Types •With gelling...
Transcript of Your Global Partner for Manufacturing, Packaging and R&D ... · HPMC Capsule Types •With gelling...
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Your Global Partner for Manufacturing, Packaging and R&D Solutions
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Emerging Trends of HPMC Capsules in
Prescription Pharmaceuticals.
CPHI - Frankfurt
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ACG Capsules : Global Footprint
Subsidiaries: Argentina, Bangladesh, Brazil, Canada, China, Croatia, Indonesia, Thailand, UAE, UK,
USA
Manufacturing: Brazil*, Europe, India
Global Head Office: India
Warehouses: Argentina, Brazil, Europe, Indonesia, Thailand, USA
*Manufacturing plant under construction
Co. Sales Manager: Colombia, Germany, France, Spain
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Content
• Introduction: Capsules vs tablets
• Capsules types
• HPMC capsules
• Future
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Capsules vs Tablets
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New Chemical Entities
Approved by EMEA & FDA
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"Tablets "Capsules "Injection "Others
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2015
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TOP 10 DRUGS LAUNCHES OF 2017NAME COMPANY DISEASE 2022 SALES
ESTIMATE
(billions$)
DOSAGE FORM
Ocrevus Roche Multiple sclerosis 4,1 Injection
Dupixent Sanofi Atopic dermatitis 4,1
Semuglutide Novo Nordisk Diabetes 2,2 Injection
Durvalumab Astra Cancer 1,9 Injection
Niraparib Tesaro Cancer 1,9 Capsules
Baricitinib Lilly Arhtritis 1,8 Capsules
LEE011 Novartis Breast cancer 1,6 Tablets
KTE-C19 Kitepharma Non- Hodkins
Limphoma
1,4 Injection
Ingrezza Neurocrine Dyskinesia 1,3 Capsules
Spinraza Biogen Muscular atrophy 1,3 Injection
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Capsule Types
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TYPES
Gelatin
GelatinPEG
HPMC
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PROPERTIES
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GELATIN
Ezeefit
GELATIN-PEG
Ezeefit
HPMC
Naturecaps
ORIGIN ANIMAL ANIMAL VEGETABLE
STRUCTURE PROTEIN PROTEIN CELLULOSE
MOISTURE
CONTENT (%)
13-16 10-12 3-8
BRITTLENESS AT
LOW RH
Yes Medium Very low
CROSSLINKING Yes Yes No
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HPMC Capsules
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HPMC Capsule Types
• With gelling agent (Naturecaps)
• Without gelling agent (Naturecaps Plus)
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NATURECAPS
• HPMC POLYMER
• GELLING AGENT
• GELLING PROMOTER
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50-55ºC 50-55ºC
20-25ºC 20-25ºC
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NATURECAPS PLUS
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Viscosity
T(ºC)
HPMC capsules cold vs hot
Cold
Hot
70-80ºC
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In vitro test: Naturecaps
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%
Time (m)
Naturecaps. ph 1,2. Paddle. Paracetamol
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HPMC Capsules Dissolution
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Nature Caps Supplier A
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Advantages
• Low moisture content.
• Better mechanical properties. No brittleness at low RH.
• Lack of crosslinking.
• No chemical interaction with APIs.
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Correlation RH / HPMC Capsule Moisture Content
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y = 0.7832e0.0367x
R² = 0.974
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Capsule
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HPMC capsule moisture content vs Relative humidity
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HPMC Capsules for Inhalation (Ezeeflo)
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From Seebri Neohaler guide
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Source “Powder Capsule and Device”. Aurelie Schouben et al. IJP 2015
Capsule puncturing (1/2)
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Capsule puncturing (2/2)
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Source “Pierce and Inhale”. F. Martinelli et
Capsule spinning
• At 60 l/m the capsule’s
angular velocity can reach
2800 rpm
• The low moment of inertia
of the capsule makes
possible such high values
• The forces generated at
this rotation deagglomerate
the mixture
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Computational Fluid Dynamic
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From “Use of computational modelling” Zhou et al University of
Sidney
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Liquid Filling
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PAST PRESENT
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THE PROBLEM
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Capsule for
liquid filling
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COMPATIBILITY
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Future
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Global HPMC Capsule Sales
(by volume in billions)
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2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
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Wide Range of Capsules
EZEEFITTM
Empty hard gelatin
capsule
NATURECAP
STM Empty hard
Cellulose (HPMC)
capsule
FLOFITTM
Empty hard capsule
for filling liquids
EZEEFLOTM
Empty hard capsule
for Dry Powder
Inhalation
MARINECAPS®
Empty hard fish gelatin
capsule
CLINICAPS®Capsule for double
blind clinical trial
PEARLZTM
Capsule with shiny
pearl-like finish
BRANDSHIELDTM
Pre-printed empty
hard capsule
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Explore What Can We Achieve
Together
We believe that our responsibility does not end by supplying the capsules as per
specifications, it begins there. With strive to add tangible value to our
strategic key customers and create a win-win partnership with them
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ACG - Values
VALUES WE LIVE.. VALUES THAT MAKES US ACG..
Transparent Aesthetics Nurturing Safety
Synergy Customer Centric Empowerment Dignity