Yellow Fever
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Transcript of Yellow Fever
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Yellow Fever
March 29, 2012
Aaron Dinerman
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Yellow Fever in Today’s World
• 200,000 Cases/Year
• 30,000 Deaths/Year
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Symptoms/Presentation
• Phase 1
• Phase 2 (Variable)
• Phase 3 (Variable; 15% of Patients reach this point)
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Yellow Fever originated from Africa….
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First Recorded Outbreak: 1648
“Xekik” = “Black Vomit”
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Worldwide Spread
“Yellow Jack”
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Wilmington, NC and Yellow Fever
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The Walter Reed Commission of 1900 and “The Mosquito
Hypothesis”
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THIS GUY, AGAIN.
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BUT….
Yellow Fever ≠ Malaria
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A Capsid Flavivirus with an Envelope
“Flavus” = Latin for “Yellow”
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Note the different binding domains for the various cleaved proteins (early virus assembly)
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The Viral Life Cycle: Overall Body Effect
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Epidemiological Cycles
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Detection/Diagnosis
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Prevention/Vaccination
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Protease Inhibitors as a Possible Therapeutic Drug?
This approach is like that of the HIV protease inhibitor paper
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Sources
• http://ncpedia.org/history/health/yellow-fever• http://www.infectionlandscapes.org/2011/07/yello
w-fever.html• http://www.who.int/mediacentre/factsheets/fs100/
en/• http://en.wikipedia.org/wiki/Yellow_fever#Histor
y• http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH
0002341/• http://vir.sgmjournals.org/content/88/8/2223.full.p
df• http://www.med.yale.edu/micropath/pdf/
Lindenbach2007.pdf