XXVIII NATIONAL SISC CONGRESS 

MILAN Programme

26 – 28 JUNE 2014 PALAZZO DELLE STELLINE CONGRESS CENTRE

Presentation This year the National SISC Congress 2014 anticipates the annual appointment with clinicians, researchers  and  more  generally  with  health  care  professionals  involved  in  the  fields  of headache and neuropathic pain in adults, children and adolescents. The scientific programme intends  to  conduct  the most  recent  findings  in  advanced  research,  the  results of  innovative interventions  and  therapeutic  procedures,  experimental  evidence  supporting  new hypotheses,  and  clinical  and  pathophysiological  definitions  of  these  disorders,  towards  a unified interpretation which can be constantly ascribable to the tangible objectives of a Care System ‐ Headache Care ‐ adhering to the foundations of a standard, qualified, validated, safe and  inexpensive health  care  assistance  in  accordance with what has been  accredited  at  the European level.  The topics proposed will therefore cover specific aspects of pathophysiology with references to basic science (thalamic pain modulation, circuits and mechanisms of abuse/drug addiction, advanced  imaging,  experimental  pain  models,  and  habituation  and  allodynia)  in  the prospective  of  identifying  the  intermediate  phenotypes of  disease,  on  the  basis  of  trait  and state  markers:  biomarkers,  neurophysiology  parameters  of  the  nociceptive  systems,  and adaptive responses related to pain and treatments.  Considerable emphasis will be placed on  the clinical  interpretation, which will  focus on  the diagnosis  of  headaches  and  the  appropriateness  criteria  of  the  diagnostic  and  therapeutic pathways  under  certain  conditions  and  subgroups,  in  relation  to  age,  gender,  history  and clinical characteristics of headache: particular  forms of migraine aura, cluster headache and other trigeminal ‐ autonomic forms, stages of reproductive life, comorbidities and interactions between treatments, critical review of old and new therapeutic  targets (triptans, anti‐CGRP, opioids,  cannabinoids,  botulinum  toxin)  and  the  latest  neurostimulation/modulation techniques and procedures.  Joint Sessions will also be proposed in this 2014 edition, in collaboration with study groups, scientific societies, associations, institutions and organizations which share the same interests and scientific and clinical objectives of our Society, whose activities are strongly characterized by  its  multidisciplinary  nature  and  constant  commitment  towards  achieving  benefits  for patients. This  is made possible by SISC’s participation in ongoing national  initiatives (Italian Migraine Project) and through the activities of the SISC Regional Sections which interact with the local health system.  As usual,  a  substantial part of  the programme will  be dedicated  to  the  specific problems of headache  in  children  and  adolescents,  to  thematic  symposia  and  plenary  discussion  of selected contributions, encouraging the participation of young clinicians and researchers with specific promotional initiatives.    Professor Giorgio Bono   President SISC  

XXVIII NATIONAL SISC CONGRESS

Honorary President Giuseppe Nappi

President

Giorgio Bono

Presidential Committee U. Balolttin, P. Calabresi, M. de Tommaso, E. Fazzi, P. Geppetti, V. Guidetti

P. Martelletti (President-Elect), F. Pierelli, L. Pinessi, L.A. Pini, G. Sandrini G. Zanchin

Scientific Committee A. Ambrosini, F. Antonaci, F. Brighina, M.G. Buzzi, G. Coppola, C. Costa

A. Ferrari, F. Galli, C. Lisotto, F. Maggioni, F. Mainardi M.P. Prudenzano, I. Rainero, G. Sances, P. Sarchielli, L. Savi

C. Tassorelli, C. Termine, E. Tozzi, A. Truini, M. Valeriani, M. Viana

Organising Committee M. Allena, P.A. Battistella, A. Costa, G. Dalla Volta

S. Guerzoni, M. Guidotti, P. Merlo

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ITALIAN SOCIETY FOR THE STUDY OF HEADCHES

Executive Committee President

Giorgio Bono

President Elect Paolo Martelletti

Past President

Luigi Alberto Pini

General Secretary Treasurer Fabio Antonaci Anna Ambrosini

Councillors

Filippo Brighina, Cinzia Costa, Pierangelo Geppetti Rosario Iannacchero, Federico Mainardi, Innocenzo Rainero

Honorary Presidents

Marcello Fanciullacci, Mario Giacovazzo, Vincenzo Guidetti Giuseppe Nappi, Lorenzo Pinessi, Emilio Sternieri, Giorgio Zanchin

Arbitrators Enrico Del Bene, Anna Ferrari, Franco Mongini

Davide Moscato, Rita Lucia Trinchi

Auditors Paola Sarchielli, Elisabetta Tozzi, Leonardo Triggiani

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Interdisciplinary School of Advanced Education in Headache

Director: Francesco Pierelli The Journal of Headache and Pain Giornale delle Cefalee (founded by SISC in 1999) Editor: Carlo Lisotto Editor-in-Chief: Paolo Martelletti

International Headache Society European Headache Federation SISC Representative: Pierangelo Geppetti SISC Representative: Luigi Alberto Pini

Scientific Programme Thursday, June 26 HALL SOLARI 13:00-14:00 Symposium with the unconditional support of Allergan Botulinum toxin type A in the treatment of chronic migraine and medication-

overuse headache: from theory to clinical practice Demonstration in small groups with certificate Chair: P. Martelletti (Rome) Instructors: A. Negro (Rome) L. D’Alonzo (Rome) HALL VOLTA 14:00-14:15 Welcome SISC Executive Committee – Authorities 14:15-14:35 Lecture The new International Classification of Headache Disorders: ICHD-3 beta:

problems and open issues C. Tassorelli (Pavia) 14:35-16:00 I Session – Headache and Pain: Hot topics Chairs: P. Calabresi (Perugia), A. Ambrosini (Pozzilli) The neurophysiological exploration in migraine F. Pierelli (Rome) CGRP as a target of pharmacological modulation  P. Geppetti (Florence)   Cortical spreading depression and migraine: new experimental evidence

      C. Costa (Perugia)   Genetic and epigenetic aspects in the modulation of pain

A.M. Persico (Rome) Discussion 16:00 Break 16:20-17:00 Magistral Lecture “Alessandro Agnoli” Presentation: G. Nappi (Pavia) The contribution of functional neuroimaging in the study of the perception of pain

C.A. Porro (Modena)

17:00-18:00 II Session – Medication-overuse headache Chairs: L. Pinessi (Turin), C. Tassorelli (Pavia) Mechanisms and circuits underlying drug addiction P. Calabresi (Perugia) The putative role of genetic factors in medication-overuse headache P. Sarchielli (Perugia) 18:00-18:45 Magistral Lecture “Giovanni Lanzi” Presentation: V. Guidetti (Rome) Focus on pharmacological treatment of pediatric migraine P.A. Battistella (Padua) 19:45 Welcome Cocktail

Friday, 27 June HALL VOLTA 8:30-10:00 Joint Session SISC – SIRN: Headache and chronic pain Chairs: G. Sandrini (Pavia), P. Sarchielli (Perugia)

Chronic migraine and neuropathic pain: similarities and differences M. Viana (Pavia)

Antidepressants, NSAIDs and chronic pain. The model of fibromyalgia M.A. Giamberardino (Chieti)

Pain in neurorehabilitation: the purpose and usefulness of the Consensus Conference

C. Tassorelli (Pavia)

Integrated rehabilitative pathways: evidence and experience M.G. Buzzi (Rome)

Discussion

10:00-11:30 Symposium – The symptomatic treatment of migraine: from past to future with the unconditional support by LUSOFARMACO Chairs: G. Zanchin (Padua)

Symptomatic treatment of migraine before triptans F. Mainardi (Venice) Symptomatic treatment of migraine in the present: the triptans M. Guidotti (Como) Symptomatic treatment of migraine in the future C. Lisotto (Pordenone)

11:30 Break 12:00-13:30 Oral communications 13:30 Lunch HALL BORROMEO 13:30-14:30 Symposium with the unconditional support of Allergan Botulinum toxin type A in the treatment of chronic migraine and medication-

overuse headache: from theory to clinical practice Demonstration in small groups with certificate Chair: P. Martelletti (Rome) Instructors: A. Negro (Rome) L. D’Alonzo (Rome)

HALL VOLTA 14:30-16:00 Joint Session SISC-SINC: Mechanisms of sensitization and allodynia Chairs: A. Truini (Rome), F. Pierelli (Rome)

Neuromodulation of nociceptive cortical responses M. de Tommaso (Bari)

The thalamo-cortical dysrhythmia in migraine G. Coppola (Rome) Excitatory/ inhibitory brain mechanisms in migraine F. Brighina (Palermo) Discussion

16:00-16:30 Magistral Lecture “Federigo Sicuteri” Presentation: M. Fanciullacci (Florence) Headache Medicine and Public Health P. Martelletti (Rome) 16:30 Break 16:50-18:10 III Session: Diagnostic pathways and comorbidity Chairs: I. Rainero (Turin), M.G. Buzzi (Rome)

A rational approach to the definition and treatment of MOH M. Allena (Pavia)

Headache in the elderly S. Sacco (L’Aquila)

Vertigo and migraine M. Versino (Pavia)

Headache and sleep disorders

M.P. Prudenzano (Bari)

Discussion 18:10-19:15 Joint Session SISC – Neuroscience and Pain Study Group (SIN)

Chairs: M. de Tommaso (Bari), F. Brighina (Palermo)

Update on the treatment of neuropathic pain A. Truini (Rome) Neuropathic pain: clinical and instrumental diagnosis M. Valeriani (Rome) Trigeminal neuralgia and trigeminal autonomic headaches: a boundary often labile A. Ambrosini (Pozzilli)

Discussion

19:15 Generale Meeting HALL SOLARI 8:30-10:00 Oral communications 10:30-12:00 Oral communications - Neuroscience and Pain Study Group 17:00-19:00 Oral communications – Juvenile headache 20:30 Social dinner

Saturday, 28 June HALL VOLTA 8:30-10:00 Joint Session SISC – INS (International Neuromodulation Society) – Italian

Chapter Chairs: G. Colini Baldeschi (Rome), P. Martelletti (Rome) Techniques, targets and applications of the neurostimulation procedures

A. Dario (Varese) Guidelines and consensus statements for the treatment of headaches with neurostimulation methods R. Arcioni (Rome) The new systems of invasive/non-invasive stimulation/modulation and technological change M. Mercieri (Rome)

10:00-10:30 Round Table – Prophylaxis in cluster headache: Do we need new therapeutic

strategies? F. Antonaci (Pavia), I. Rainero (Turin), G. Zanchin (Padua) 10:30 Break 11:00-13:30 Joint Session SISC – ANIRCEF: Headache Care and care models Chairs: G. Bono (Varese), F. Pierelli (Roma)

The Manifesto of the Rights of the Patient: The Italian Migraine Project M. Aguggia (Asti) The role of the pharmacist in the management of pain Federfarma Lombardy Criteria for the accreditation of headache centres and networks G. Sances (Pavia) Operational models of the Integrated Regional Network: Calabria Region - R. Iannacchero (Catanzaro) Veneto Region - F. Mainardi (Venice) Emilia Romagna Region – L.A. Pini (Modena)

Discussion 13:30 Closing ceremony and CME evaluation HALL BORROMEO 8:30-10:00 Oral communications HALL AGNESI 9:30-11:00 Meeting with the Patient Associations

Saturday, 28 June

Pediatric Sessione and Teaching Course – Headaches in the developmental age Coordinators: Umberto Balottin (Pavia), Vincenzo Guidetti (Rome)

HALL SOLARI 8:30- 9:15 “If I sleep the headache increases” M. Carotenuto (Naples) 9:15-10:00 When the primary headache masks something else – part 1 E. Tozzi (L’Aquila) 10:00-10:45 “I see a light in front of my eye” P. Verdecchia (Rome) 10:45-11:00 Break 11:00-11:45 Headache in pediatric practice P. Balestri (Siena) 11:45-12:30 “My child is so small, can he/she have a headache?” M. Valeriani (Rome) 12:30-13:15 When the therapy does not work P.A. Battistella (Padua) 13:15-14:15 Lunch 14:15-15:00 “When my child says he/she has a headache, I don’t understand if he/she is pretending” U. Balottin (Pavia) 15:00-15:45 “At school, I get a headache” C. Termine (Varese) 15:45-16:30 “Could it be the short-sightedness?” " E. Fazzi, R. Micheli (Brescia) 16:30-17:15 “Is it a headache or a seizure?” B. Dalla Bernardina (Verona) 17:15-18:00 When the primary headache masks something else – part 2 F. Neri, R. Nacinovich and F. Corbetta (Milan) 18:00-18:15 Closing ceremony and CME evaluation

FACULTY Marco Aguggia - Asti Marta Allena - Pavia Anna Ambrosini - Pozzilli Fabio Antonaci - Pavia Roberto Arcioni – Rome Paolo Balestri - Siena Umberto Balottin - Pavia Pier Antonio Battistella - Padua Giorgio Bono – Varese Filippo Brighina - Palermo Maria Gabriella Buzzi - Rome Paolo Calabresi - Perugia Marco Carotenuto - Naples Domenico Cassano – Nocera Inferiore Gianluca Coppola - Latina Fabiola Corbetta - Milan Cinzia Costa - Perugia Giorgio Dalla Volta - Brescia Lidia D'Alonzo – Rome Alessandro Dario - Varese Enrico Del Bene - Firenze Marina de Tommaso – Bari Maurizio Evangelista - Rome Marcello Fanciullacci - Florence Elisa Fazzi - Brescia Anna Ferrari - Modena Pierangelo Geppetti – Florence Maria Adele Giamberardino – Chieti Vincenzo Guidetti - Rome Mario Guidotti - Como Rosario Iannacchero – Catanzaro Carlo Lisotto - Pordenone

Ferdinando Maggioni - Padua Federico Mainardi – Venice Paolo Martelletti – Rome Marco Mercieri - Rome Roberto Micheli - Brescia Andrea Negro - Rome Francesca Neri - Milan Alessandro Panconesi - Empoli Antonello M. Persico - Rome Francesco Pierelli - Latina Lorenzo Pinessi - Turin Luigi Alberto Pini – Modena Carlo Adolfo Porro - Modena Maria Pia Prudenzano – Bari Vincenzo Raieli - Palermo Innocenzo Rainero – Turin Simona Sacco – L'Aquila Grazia Sances - Pavia Giorgio Sandrini - Pavia Paola Sarchielli - Perugia Lidia Savi – Turin Cristina Tassorelli – Pavia Cristiano Termine - Varese Elisabetta Tozzi - L'Aquila Andrea Truini - Rome Massimiliano Valeriani - Rome Paola Verdecchia – Rome Maurizio Versino - Pavia Michele Viana - Pavia Giorgio Zanchin – Padua

GENERAL INFORMATION

VENUE Palazzo delle Stelline Centro Congressi Corso Magenta, 61 20123 Milan

ORGANISING SECRETARIAT Reference office for XXVIII National SISC Congress PRATO Via Jacopo Melani 19/23 59016 Poggio a Caiano (PO) Other offices Tel. 055.8797796 Fax 055.8797843 Contact: Roberta Bianchi ROMA roberta.bianchi@nicocongressi.it; Registered Office: info@nicocongressi.it Via Aurora, 39 – 00187 Roma www.nicocongressi.it Tel. 06.48906436 Fax 06.4821566

CONGRESS REGISTRATION FEES

SISC Members    € 380,00 

Non‐members and members not in good standing with member fees    € 480,00 

Under 35 years of age*    € 253,00 

Residents/Doctoral degree Students    € 172,00 

Special Congress Package (under 35 years of age)**    € 343,00 

Daily registration fee    € 130,00 

  (22% VAT included) 

* The reduced rate will be accepted by the Organising Secretariat only if payment is accompanied by a copy of a valid ID.

** A Special Congress Package is available for members of the Italian Society for the Study of

Headaches under 35 years of age which includes registration to the Congress and accommodation in a double room, for 2 nights, in a 3 star hotel, including breakfast. The request will be accepted by the Organising Secretariat only if payment is accompanied by a copy of a valid ID.

Registration fees include: participation in scientific sessions, congress material, certificate of attendance and CME certificate, Congress proceedings, coffee access points, lunch, welcome cocktail and social event. Daily  registration  fee  includes: participation in scientific sessions, congress material, certificate of attendance, Congress proceedings, coffee access points, lunch, welcome cocktail and social event.

TEACHING COURSE REGISTRATION FEES    

Teaching Course 28 June 2014 Headaches in the developmental age    € 100,00 

Residents/Doctoral degree Students*    € 40,00 

  (22% VAT included) 

* Students must present a certificate of registration to a Postgraduate School. Registration fee includes: certificate of attendance and CME certificate, coffee access points and lunch. CANCELLATION POLICY All cancellations must to be sent in writing to the Organising Secretariat. Cancellations received by April 30, 2014 will be refunded 30% of the registration fee after the congress. After this date no refund will be made. CHANGES The Congress organisers reserve the right to make any necessary changes to the program, including registration fees for scientific, technical or logistical reasons. Please check the websites: www.sisc.it and www.nicocongressi.it for regular updates. REGISTRATION

The application form together with a copy of the bank transfer must be sent by fax to 055 8797843. Registration by phone will not be taken into consideration. Payment must be made by bank transfer to:

Account name: NICO srl Bank details: Credito Cooperativo Piazza Michelacci 1/2 - 50058 Signa (FI) Bank code: ABI – 08866 CAB – 38110 C/C 000000081105 SWIFT CODE – ICRAIT3FO20 IBAN no: IT34N0886638110000000081105

ONLINE REGISTRATION Online registration is available at the Organising Secretariat’s website - www.nicocongressi.it, click on "Events and Conferences" and then on “SISC National Congress” and proceed with the online registration with payment by credit card in security certificate mode Paypal.

CME CREDITS

The XXVIII National Congress SISC has obtained 10 CME credits for the professional figures of: • Pharmacist in the disciplines of: Hospital Pharmacy, Territorial Pharmacy. • Nurse. • Pediatric Nurse. • Physicians in the disciplines of: Anestesiolgia and Intensive Care, Child Neuropsychiatry,

Clinical Pharmacology and Toxicology, Continuity of care, Diagnostic Radiology, Endocrinology, Forensic Medicine, General Medicine (Family Physicians), Gynecology and Obstetrics, Internal Medicine, Neurophysiology, Neurology, Pediatrics, Pediatrics (PLS), Psychiatry, Rheumatology.

• Psychologist in the disciplines of: Psychotherapy, Psychology. • Technical Neurophysiology. The Teaching Course "The headaches in the developmental age" has obtained 9 CME credits for the professional figures of: • Physicians in the disciplines of: Child Neuropsychiatry, Pediatrics, Pediatrics (PLS) and for

Psychologists. • Psychologist in the disciplines of: Psychotherapy, Psychology. • Therapist of neuro and psychomotor developmental age. In order to be eligible for receipt of CME credits, each participant must attend the whole programme, complete a multiple choice test and a valuation form of the event. The attendance of each participant will be register upon entry and exit of each session accredited. ATTENDANCE CERTIFICATE

The certificate of attendance will be given to participants at the end of the congress at the Secretariat Desk. HOTEL ACCOMMODATION

Please contact the Organising Secretariat NICO Congressi. EXHIBITION

A technical, pharmaceutical and publication exhibition will take place during the Congress. TECHNICAL AND AUDIOVISUAL SUPPORT Presentation format is PowerPoint. For specific requests, please contact the Organising Secretariat NICO Congressi. ORAL PRESENTATIONS AND POSTERS The Congress will be organised in lectures, oral and poster presentations. All abstracts will be reviewed by the Scientific Committee. At least one of the authors must be a registered participant.