[XLS] Database.xls · Web viewGeneric Numerical Standards Inhalation URF Metadata Oral SLope Factor...

OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)

V /

NV

Ref

eren

ce Melting

Ref

eren

ce Henry's Law

Ref

eren

ce Henry's Law

Ref

eren

ce

Ref

eren

ce Water

Ref

eren

ce Air

Ref

eren

ce Water

Ref

eren

ce

CAS MW Point Constant Dimensionless Koc logKow Solubility Diffusivity Diffusivity PC FA

Number (gm/mol) (°C) (H') (L/kg) (L/kg) (cm2/s) (cm2/s) (cm/hr)

Volatile Organic Compounds References:Acetone 67-64-1 V 58.08 b -94.80 b 1.87E-05 b 7.65E-04 5.75E-01 e -2.40E-01 c 1.00E+06 c 1.24E-01 h 1.14E-05 h 1 NA 1.10E-03 1 a. CHEMFATE. Environmental Fate Data Base. Syracuse Research Corporation.

Benzene 71-43-2 V 78.11 b 5.50 b 5.55E-03 c 2.27E-01 6.17E+01 e 2.13E+00 c 1.79E+03 b 8.80E-02 h 1.02E-05 h 1 NA 1.50E-02 1 (http://www.syrres.com/esc/chemfate.htm)

Carbon Disulfide 75-15-0 V 76.14 b -111.50 b 1.44E-02 b 5.89E-01 4.57E+01 e 1.94E+00 c 2.86E+03 b 1.04E-01 h 1.00E-05 h 1 NA 1.70E-02 1 b. Hazardous Substance Data Bank (HSDB). Toxicology Data Netework.

Carbon Tetrachloride 56-23-5 V 153.82 b -23.00 b 3.04E-02 b 1.24E+00 1.52E+02 e 2.83E+00 c 1.16E+03 b 7.80E-02 h 8.80E-06 h 1 NA 1.60E-02 1 (http://toxnet.nlm.nih.gov)

Chlorobenzene 108-90-7 V 112.56 b -45.20 b 3.11E-03 c 1.27E-01 2.24E+02 e 2.89E+00 b 5.02E+02 b 7.30E-02 h 8.70E-06 h 1 NA 2.80E-02 1 c. PHYSPROP. Syracuse Research Corporation.

Chloroethane 75-00-3 V 64.51 b -138.70 b 1.11E-02 b 4.54E-01 2.40E+01 b 1.43E+00 c 6.71E+03 c 2.71E-01 h 1.15E-05 h 1 NA 6.80E-03 1 (http://www.syrres.com/esc/physdemo.htm)

Chloroform 67-66-3 V 119.38 b -63.20 b 3.67E-03 b 1.50E-01 5.25E+01 e 1.97E+00 c 7.71E+03 b 1.04E-01 h 1.00E-05 h 1 NA 6.80E-03 1 d. Risk Assessment Information System (RAIS). Oak Ridge National Laboratory.

Dibromochloromethane 124-48-1 V 208.28 b -20.00 b 7.83E-04 b 3.20E-02 8.40E+01 b 2.16E+00 c 2.70E+03 b 3.66E-02 h 1.05E-05 h 1 NA 4.20E-02 1Dichlorodifluoromethane 75-71-8 V 120.91 b -158.00 b 3.43E-01 b 1.40E+01 3.56E+02 b 2.16E+00 c 2.80E+02 b 6.65E-02 h 9.92E-06 h 1 NA 9.00E-03 1 e.US EPA, 1996. Soil Screening Guidance.

Dichloroethane, 1,1 - 75-34-3 V 98.97 b -96.90 b 5.62E-03 b 2.30E-01 5.34E+01 e 1.79E+00 c 5.04E+03 b 7.42E-02 h 1.05E-05 h 1 NA 6.70E-03 1 (http://www.epa.gov/superfund/resources/soil/index.htm)

Dichloroethane, 1,2 - 107-06-2 V 98.96 b -35.30 b 1.18E-03 b 4.83E-02 3.80E+01 e 1.48E+00 c 8.60E+03 b 1.04E-01 h 9.90E-06 h 1 NA 4.20E-03 1 f. US EPA, 2004. Superfund Chemical Data Matrix (SCDM).

Dichloroethene, 1,1 - 75-35-4 V 96.94 b -122.50 b 2.61E-02 b 1.07E+00 6.50E+01 e 2.13E+00 c 2.42E+03 b 9.00E-02 h 1.04E-05 h 1 NA 1.20E-02 1 (http://www.epa.gov/superfund/sites/npl/hrsres/tools/scdm.htm)

156-59-2 V 96.94 b -80.00 b 4.08E-03 b 1.67E-01 3.55E+01 e 1.86E+00 c 6.41E+03 b 8.86E-02 h 1.13E-05 h 1 NA 2.70E-02 1 g. US EPA, 2002. Supplemental Guidance for Developing Soil Screening Levels for Superfund Sites.

156-60-5 V 96.94 b -49.80 b 9.38E-03 c 3.84E-01 3.80E+01 e 2.09E+00 c 4.52E+03 b 7.03E-02 h 1.19E-05 h 1 NA 7.70E-03 1 (http://www.epa.gov/superfund/resources/soil/index.htm)

Dichloropropane, 1,2 - 78-87-5 V 112.99 b -100.40 b 2.82E-03 b 1.15E-01 4.70E+01 e 1.98E+00 c 2.80E+03 b 7.82E-02 h 8.73E-06 h 1 NA 7.80E-03 1 h. Water 9. (http://www.epa.gov/ttn/chief/software/water/)

Dichloropropene, 1,3 - 542-75-6 V 110.97 b -48.00 a 3.55E-03 b 1.45E-01 2.71E+01 e 2.04E+00 c 2.80E+03 b 6.26E-02 h 1.00E-05 h 1 NA 4.30E-03 1Dioxane, 1,4 - 123-91-1 V 88.10 b 11.80 b 4.80E-06 b 1.96E-04 2.90E+01 b -2.70E-01 c 1.00E+06 c 2.29E-01 h 1.02E-05 h 1 NA 3.30E-04 1Ethyl Ether 60-29-7 V 74.12 b -116.30 b 1.23E-03 b 5.03E-02 7.30E+01 b 8.90E-01 c 6.04E+04 b 7.82E-02 h 8.61E-06 h 1 NA 2.30E-03 1Ethylbenzene 100-41-4 V 106.16 b -94.90 b 7.88E-03 b 3.22E-01 2.04E+02 e 3.15E+00 c 1.69E+02 b 7.50E-02 h 7.80E-06 h 1 NA 4.90E-02 1Formaldehyde 50-00-0 V 30.03 b -92.00 b 3.37E-07 b 1.38E-05 3.70E+01 b 3.50E-01 c 4.00E+05 b 1.78E-01 h 1.98E-05 h 1 NA 1.80E-03 1Formic acid 64-18-6 V 46.03 b 8.40 b 1.67E-07 b 6.83E-06 1.20E+01 b -5.40E-01 c 1.00E+06 c 7.90E-02 h 1.37E-06 h 1 NA 6.90E-04 1

110-54-3 V 86.17 b -94.30 b 1.83E+00 b 7.49E+01 1.50E+02 b 3.90E+00 c 1.24E+01 b 2.00E-01 h 7.77E-06 h 1 NA 5.90E-01 1Isobutyl Alcohol 78-83-1 V 74.12 b -108.00 b 9.78E-06 b 4.00E-04 6.20E+01 b 7.60E-01 c 8.50E+04 b 8.60E-02 h 9.30E-06 h 1 NA 5.00E-03 1Methanol 67-56-1 V 32.04 b -97.80 b 4.55E-06 b 1.86E-04 1.00E+00 b -7.70E-01 c 1.00E+06 c 1.50E-01 h 1.64E-05 h 1 NA 3.20E-04 1Methyl Ethyl Ketone (MEK) 78-93-3 V 72.11 b -86.00 b 4.70E-05 b 1.92E-03 3.15E+01 b 2.90E-01 c 3.53E+05 b 8.08E-02 h 9.80E-06 h 1 NA 9.60E-04 1Methyl Isobutyl Ketone (MIBK) 108-10-1 V 100.16 b -85.00 b 1.38E-04 b 5.64E-03 1.23E+02 b 1.31E+00 b 1.90E+04 b 7.50E-02 h 7.80E-06 h 1 NA 1.20E-02 1

1634-04-4 V 88.15 b -108.60 b 5.87E-04 b 2.40E-02 6.00E+00 b 9.40E-01 c 4.80E+04 b 8.59E-02 h 1.01E-05 h 1 NA 7.00E-03 1Methylene Chloride 75-09-2 V 84.93 b -95.00 b 2.19E-03 a 8.96E-02 1.00E+01 e 1.25E+00 c 1.30E+04 b 1.01E-01 h 1.17E-05 h 1 NA 3.50E-03 1Styrene 100-42-5 V 104.15 b -31.00 b 2.75E-03 b 1.12E-01 9.12E+02 e 2.95E+00 c 3.10E+02 b 7.10E-02 h 8.00E-06 h 1 NA 3.70E-02 1Tetrachloroethane , 1,1,1,2 - 630-20-6 V 167.85 b -70.20 b 2.50E-03 c 1.02E-01 9.66E+01 d 2.93E+00 c 1.07E+03 c 7.10E-02 h 7.90E-06 h 1 NA 1.40E-01 1Tetrachloroethane, 1,1,2,2 - 79-34-5 V 167.85 b -43.80 b 3.67E-04 b 1.50E-02 7.90E+01 e 2.39E+00 c 2.90E+03 b 7.10E-02 h 7.90E-06 h 1 NA 6.90E-03 1Tetrachloroethene 127-18-4 V 165.83 b -22.30 b 1.77E-02 b 7.24E-01 2.65E+02 e 3.40E+00 c 2.06E+02 c 7.20E-02 h 8.20E-06 h 1 NA 3.30E-02 1Toluene 108-88-3 V 92.14 b -94.90 b 6.64E-03 b 2.72E-01 1.40E+02 e 2.73E+00 c 5.26E+02 b 8.70E-02 h 8.60E-06 h 1 NA 3.10E-02 1Trichloroethane, 1,1,1 - 71-55-6 V 133.42 b -30.40 b 1.72E-02 c 7.04E-01 1.35E+02 e 2.49E+00 c 1.29E+03 c 7.80E-02 h 8.80E-06 h 1 NA 1.30E-02 1Trichloroethane, 1,1,2 - 79-00-5 V 133.42 b -36.60 b 8.24E-04 b 3.37E-02 7.50E+01 e 1.89E+00 c 4.59E+03 c 7.80E-02 h 8.80E-06 h 1 NA 6.40E-03 1Trichloroethene 79-01-6 V 131.39 b -84.70 b 1.03E-02 a 4.21E-01 9.43E+01 e 2.42E+00 c 1.28E+03 b 7.90E-02 h 9.10E-06 h 1 NA 1.20E-02 1Trichlorofluoromethane 75-69-4 V 137.37 b -111.00 b 9.70E-02 b 3.97E+00 9.70E+01 b 2.53E+00 c 1.10E+03 b 8.70E-02 h 9.70E-06 h 1 NA 1.30E-02 1Trichloropropane, 1,2,3 - 96-18-4 V 147.43 b -14.70 b 3.43E-04 b 1.40E-02 8.60E+01 b 2.27E+00 c 1.75E+03 b 7.10E-02 h 7.90E-06 h 1 NA 5.00E-02 1Vinyl Chloride 75-01-4 V 62.50 b -153.70 b 2.78E-02 b 1.14E+00 1.86E+01 e 1.62E+00 c 2.70E+03 b 1.06E-01 h 1.23E-05 h 1 NA 1.50E-04 1Xylenes, Total 1330-20-7 V 106.16 b -25.20 d 7.00E-03 b 2.86E-01 5.56E+02 b 3.16E+00 c 1.06E+02 c 7.37E-02 h 9.34E-06 h 1 NA 1.90E-01 1

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9 NV 154.21 b 95.00 b 1.84E-03 c 7.53E-02 4.90E+03 e 3.92E+00 c 3.90E+00 c 4.76E-02 h 7.69E-06 h 1 0.13 6.10E-01 1Acetophenone 98-86-2 NV 120.15 b 20.50 b 1.04E-05 b 4.25E-04 1.00E+01 b 1.58E+00 c 6.13E+03 b 6.00E-02 h 8.73E-06 h 1 0.1 1.70E-02 1Acrylonitrile 107-13-1 NV 53.06 b -82.00 b 1.38E-04 b 5.64E-03 3.30E+01 b 2.50E-01 c 7.45E+04 b 1.22E-01 h 1.34E-05 h 1 0.1 1.20E-03 1Aniline 62-53-3 NV 93.13 b -6.00 b 2.02E-06 b 8.26E-05 2.71E+02 b 9.00E-01 c 3.60E+04 b 7.00E-02 h 8.30E-06 h 1 0.1 1.90E-03 1Anthracene 120-12-7 NV 178.23 b 218.00 b 4.88E-05 b 2.00E-03 2.34E+04 e 4.45E+00 c 1.29E+00 b 3.85E-02 h 7.74E-06 h 1 0.13 1.37E+00 1Benzidine 92-87-5 NV 184.24 b 120.00 b 5.20E-11 b 2.13E-09 5.55E+05 b 1.34E+00 c 3.22E+02 b 3.26E-02 h 1.50E-05 h 1 0.1 1.10E-03 1Benzo(a)anthracene 56-55-3 NV 228.29 b 160.00 b 1.20E-05 c 4.91E-04 3.58E+05 e 5.79E+00 b 9.40E-03 b 5.10E-02 h 9.00E-06 h 1 0.13 4.70E-01 1Benzo(a)pyrene 50-32-8 NV 252.32 b 176.50 c 4.57E-07 b 1.87E-05 9.69E+05 e 6.13E+00 c 1.60E-03 b 4.30E-02 h 9.00E-06 h 1 0.13 7.00E-01 1Benzo(b)fluoranthene 205-99-2 NV 252.32 b 168.00 b 5.00E-07 b 2.05E-05 1.23E+06 e 6.60E+00 b 1.50E-03 b 2.23E-02 h 5.56E-06 h 1 0.13 7.00E-01 1Benzo(k)fluoranthene 207-08-9 NV 252.32 b 217.00 b 5.84E-07 b 2.39E-05 1.23E+06 e 6.11E+00 c 8.00E-04 b 2.23E-02 h 5.56E-06 h 1 0.13 1.71E+01 1Bis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 NV 390.56 b -55.00 b 1.30E-07 b 5.32E-06 1.11E+05 e 7.60E+00 c 2.85E-01 b 3.51E-02 h 3.66E-06 h 1 0.1 1.64E+02 1Butyl Benzyl Phthalate 85-68-7 NV 312.39 b -35.00 b 4.78E-06 b 1.96E-04 1.37E+04 e 4.73E+00 c 7.10E-01 b 1.99E-02 h 4.89E-06 h 1 0.1 2.10E+00 1Carbazole 86-74-8 NV 167.20 b 245.00 b 8.65E-08 b 3.54E-06 3.39E+03 e 3.72E+00 c 1.80E+00 c 4.17E-02 h 7.45E-06 h 1 0.1 4.50E-01 1Chlordane 57-74-9 NV 409.80 b 106.00 c 4.86E-05 b 1.99E-03 5.13E+04 e 6.16E+00 c 5.60E-02 b 1.79E-02 h 4.37E-06 h 1 0.04 3.80E-02 1Chrysene 218-01-9 NV 228.29 b 258.20 b 5.23E-06 c 2.14E-04 3.98E+05 e 5.81E+00 c 1.89E-02 b 2.44E-02 h 6.21E-06 h 1 0.13 4.70E-01 1Dibenz(a,h)anthracene 53-70-3 NV 278.33 b 266.00 b 1.20E-07 b 4.91E-06 1.79E+06 e 6.50E+00 b 5.99E-04 b 2.11E-02 h 5.24E-06 h 1 0.13 3.10E+01 1Dichlorobenzene, 1,2 - (o) 95-50-1 NV 147.00 b -16.70 b 1.92E-03 c 7.85E-02 3.79E+02 e 3.43E+00 c 1.56E+02 b 6.90E-02 h 7.90E-06 h 1 0.1 4.10E-02 1Dichlorobenzene, 1,4 - (p) 106-46-7 NV 147.00 b 52.70 b 2.41E-03 b 9.86E-02 6.16E+02 e 3.44E+00 c 7.60E+01 b 6.90E-02 h 7.90E-06 h 1 0.1 4.20E-02 1Dichlorobenzidine, 3,3 - 91-94-1 NV 253.13 b 132.00 d 2.80E-11 b 1.15E-09 7.24E+02 e 3.51E+00 c 3.10E+00 b 2.59E-02 h 6.74E-06 h 1 0.1 1.30E-02 1Dichlorodiphenyldichloroethane (DDD) 72-54-8 NV 320.04 b 109.00 c 6.60E-06 b 2.70E-04 4.58E+04 e 6.02E+00 c 1.60E-01 b 2.27E-02 h 5.79E-06 h 1 0.03 1.80E-01 1Dichlorodiphenyldichloroethene (DDE) 72-55-9 NV 318.03 b 89.00 b 4.16E-05 b 1.70E-03 8.64E+04 e 6.51E+00 b 6.50E-02 b 2.38E-02 h 5.87E-06 h 1 0.03 1.60E-01 1Dichlorodiphenyltrichloroethane (DDT) 50-29-3 NV 354.49 b 108.50 b 8.30E-06 b 3.39E-04 6.78E+05 e 6.91E+00 c 5.50E-03 b 1.99E-02 h 4.95E-06 h 1 0.03 2.70E-01 1Dichlorophenoxyacetic acid, 2,4 - 94-75-7 NV 221.04 b 138.00 b 8.60E-06 b 3.52E-04 7.80E+01 b 2.81E+00 c 6.77E+02 b 5.88E-02 h 6.49E-06 h 1 0.1 1.10E-01 1Diethyl Phthalate 84-66-2 NV 222.24 b -40.50 b 6.10E-07 b 2.50E-05 8.22E+01 e 2.42E+00 c 1.00E+03 b 2.49E-02 h 6.35E-06 h 1 0.1 3.90E-03 1Dimethylphenol, 2,4 - 105-67-9 NV 122.17 b 24.54 a 9.51E-07 c 3.89E-05 2.09E+02 e 2.30E+00 c 7.87E+03 b 6.43E-02 h 8.69E-06 h 1 0.1 1.10E-02 1Di-n-butyl Phthalate 84-74-2 NV 278.35 b -35.00 b 4.50E-06 b 1.84E-04 1.57E+03 e 4.50E+00 c 1.12E+01 b 4.38E-02 h 7.86E-06 h 1 0.1 2.40E-02 1

99-65-0 NV 168.11 b 90.00 c 4.90E-08 b 2.00E-06 1.50E+02 b 1.49E+00 c 8.61E+02 a 4.55E-02 h 8.46E-06 h 1 0.1 1.50E-02 1Dinitrobenzene, 1,2 - 528-29-0 NV 168.11 b 118.50 c 5.30E-08 b 2.17E-06 2.00E+02 b 1.69E+00 c 1.33E+02 b 3.95E-02 h 7.01E-06 h 1 0.1 2.10E-02 1Dinitrotoluene, 2,4 - 121-14-2 NV 182.14 b 71.00 b 5.40E-08 c 2.21E-06 3.60E+02 b 1.98E+00 c 2.70E+02 b 2.03E-01 h 7.06E-06 h 1 0.102 3.10E-03 1Dinitrotoluene, 2,6 - 606-20-2 NV 182.14 b 66.00 b 9.26E-08 b 3.79E-06 4.55E+01 b 2.10E+00 c 1.82E+02 c 3.70E-02 h 7.76E-06 h 1 0.099 2.10E-03 1Endrin 72-20-8 NV 380.91 b 200.00 b 6.36E-06 b 2.60E-04 1.08E+04 e 5.20E+00 b 2.50E-01 b 1.92E-02 h 4.74E-06 h 1 0.1 1.20E-02 1Ethylene Glycol 107-21-1 NV 62.07 b -13.00 b 6.00E-08 a 2.45E-06 1.00E+00 b -1.36E+00 c 1.00E+06 c 1.08E-01 h 1.22E-05 h 1 0.1 2.00E-04 1Fluoranthene 206-44-0 NV 202.26 b 111.00 b 9.45E-06 b 3.87E-04 4.91E+04 e 5.16E+00 c 1.20E-01 b 2.51E-02 h 6.35E-06 h 1 0.13 2.20E-01 1Fluorene 86-73-7 NV 166.21 b 114.80 c 9.62E-05 c 3.93E-03 7.71E+03 e 4.18E+00 c 1.69E+02 c 4.40E-02 h 7.88E-06 h 1 0.13 9.10E-01 1Heptachlor 76-44-8 NV 373.32 b 95.50 c 2.94E-04 b 1.20E-02 9.53E+03 e 6.10E+00 c 1.80E-01 b 2.23E-02 h 5.69E-06 h 1 0.1 8.60E-03 1Heptachlor Epoxide 1024-57-3 NV 389.40 b 160.00 c 2.10E-05 c 8.59E-04 8.32E+04 e 4.98E+00 c 3.50E-01 b 2.19E-02 h 5.57E-06 h 1 0.1 3.10E+00 1

Chemical (Synonyms in comments) Oral

AbsorptDermal Absorpt(atms-m3/mol) (mg/L H2O)

(http://risk.lsd.ornl.gov)

Dichloroethene, cis - 1,2 Dichloroethene, trans - 1,2 -

Hexane, n -

Methyl tert- Butyl Ether (MTBE)

1,3-Dinitrobenzene, meta -

http://risk.lsd.ornl.gov)/

B3

VAP: Chemical Abstract System

F3

VAP: The temperature at which liquid and solid coexist in equilibrium.

H3

VAP: The ratio of the aqueous-phase concentration of a chemical to its equilibrium partial pressure in the gas phase. A measure of the limiting solubility of a solute in a solvent, A higher HLC corresponds to a lower solubility.

J3

Converted from Henry's Law (atms-m3/mol)

K3

VAP: Soil organic carbon-water partitioning coefficient, measured value reported where available.

M3

VAP: The octanol-water partition coefficient (Kow) is a measure of the equilibrium concentration of a compound between octanol and water that indicates the potential for partitioning into soil organic matter (i.e., a high Kow indicates a compound which will preferentially partition into soil organic matter rather than water). Kow is inversely related to the solubility of a compound in water. Log Kow is used in models to estimate plant and soil invertebrate bioaccumulation factors.

O3

VAP: The maximum amount of a substance that can dissolve in water at equilibrium at a given temperature and pressure.

Q3

VAP: Molecular diffusivity of contaminant in soil air pore.

U3

U.S.EPA (2004). Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual, Part E, Supplemental Guidance for Dermal Risk Assessment. EPA/540/R/99/005. July 2004.

V3

U.S.EPA (2004). Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual, Part E, Supplemental Guidance for Dermal Risk Assessment. EPA/540/R/99/005. July 2004.

W3

Permeability Constant (Kp) Values obtained from Appendix B or calculated using equation 3.8. Reference: U.S.EPA (2004). Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual, Part E, Supplemental Guidance for Dermal Risk Assessment. EPA/540/R/99/005. July 2004.

X3

VAP: Fraction Absorbed (GW) dimensionless.

D4

VAP: Daltons

A6

Acetone Synonyms: ACETON DIMETHYLFORMALDEHYDE DIMETHYLKETAL DIMETHYL KETONE KETONE, DIMETHYL KETONE PROPANE beta-KETOPROPANE METHYL KETONE PROPANONE 2-PROPANONE PYROACETIC ACID PYROACETIC ETHER RCRA WASTE NUMBER U002 UN 1090

D6

[Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 76th ed. Boca Raton, FL: CRC Press Inc., 1995-1996., p. 3-284]**PEER REVIEWED**

F6


H6

@ 25 degrees C [Benkelbberg HJ et al; J Atmos Chem 20: 17-34 (1995)]**PEER REVIEWED**

M6

HANSCH,C ET AL. (1995)

O6

@ 25 degrees C RIDDICK,JA ET AL. (1986)

A7

Benzene Synonyms: benzol coal naphtha cyclohexatriene phene phenyl hydride polystream pyrobenzol

D7

[Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 179]**PEER REVIEWED**

F7


H7

@ 25 degrees C MACKAY,D ET AL. (1979)

M7


O7

@ 25 degrees C [May WE et al; J Chem Ref Data 28: 197-0200 (1983)]**PEER REVIEWED**

A8

Carbon Disulfide Synonyms: CARBON BISULFIDE CARBON BISULPHIDE CARBON DISULPHIDE CARBONE (SUFURE DE) CARBONIO (SOLFURO DI) CARBON SULFIDE CARBON SULPHIDE DITHIOCARBONIC ANHYDRIDE KOHLENDISULFID KOOLSTOFDISULFIDE NCI-C04591 RCRA WASTE NUMBER P022 SOLFURO di CARBONIO SULPHOCARBONIC ANHYDRIDE UN 1131 WEEVILTOX

D8


F8


H8

@ 24 degrees C [Elliot S; Atmos Environ 23: 1977-80 (1989)]**PEER REVIEWED**

M8


O8

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, Univ of Ariz - Tucson, AZ. PC Version (1992)]**PEER REVIEWED**

A9

Carbon Tet Synonyms: Acritet Benzinoform Carbona Carbon chloride Carbo tetrachloride ENT 4,705 Fasciolin Flukoids Freon 10 Halon 104 Mecatorina Methane tetrachloride Methane, tetrachloro- Necatorina Necatorine Perchloromethane R 10 Tetrachloormetaan Tetrachlormethan Tetrachlorocarbon Tetrachloromethane Tetrafinol Tetraform Tetrasol Univerm Ventox Vermoestricid

D9


F9


H9

@ 24.8 degrees C [Gossett JM, Environ Sci Tech 21: 202-8 (1987)]**PEER REVIEWED**

M9


O9

@ 25 degrees C [Verschueren, K. Handbook of Environmental Data on Organic Chemicals. 3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996., p. 422]**PEER REVIEWED**

A10

Chlorobenzene Synonyms: BENZENE CHLORIDE BENZENE, CHLORO- CHLORBENZENE CHLORBENZOL CHLOROBENZOL MCB MONOCHLORBENZENE MONOCHLOROBENZENE NCI-C54886 PHENYL CHLORIDE UN 1134

D10


F10


H10

@ 25 degrees C SHIU,WY & MACKAY,D (1997)

M10

[Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 17]**PEER REVIEWED**

O10


A11

Chloroethane Synonyms: Aethylis AETHYLIS CHLORIDUM Anodynon Chelen Chlorene Chlorethyl Chloridum Chloroethane Chloryl CHLORYL ANESTHETIC Cloretilo Dublofix ETHANE, CHLORO- ETHER CHLORATUS ETHER HYDROCHLORIC ETHER MURIATIC Ethyl Chloride HSDB 533 Hydrochloric ether Kelene Monochlorethane Monochloroethane Muriatic ether Narcotile NCI-CO6224 UN 1037

D11


F11


H11

@ 24 degrees C [Gossett JM; Env Sci Technol 21: 202-6 (1987)]**PEER REVIEWED**

K11

(SRC) determined from a structure estimation method [Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992)] **PEER REVIEWED**

M11


O11

@ 25 degrees C HORVATH,AL ET AL. (1999)

A12

Chloroform Synonyms: Formyl Trichloride Freon 20 Methane Trichloride Methane, Trichloro- Methenyl Chloride Methenyl Trichloride Methyl Trichloride NCI-CO2686 R-20 TCM Trichloroform Trichloromethane

D12


F12

[Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V5 (93) 1052]**PEER REVIEWED**

H12

@ 24 degrees C [Gossett JM; Environ Sci Tech 21: 202-6 (1987)]**PEER REVIEWED**

M12


O12

@ 25 degrees C [Dewulf J, VanLangenhove H; Wat Res 31: 1825-38 (1997)]**PEER REVIEWED**

A13

Dibromochloromethane Synonyms: Chlorodibromomethane Dibromomonochloromethane Methane, dibromochloro- Monochlorodibromomethane

D13

[Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V4: 3360]**PEER REVIEWED**

F13


H13

@ 20 degrees C [Warner HP et al; Determination of Henry's Law Constants of Selected Priority Pollutants. USEPA/600/D-87/229, NTIS PB87-212684 (1987) ]**PEER REVIEWED**

K13

Chu W, Chan KH; Sci Total Environ 248: 1-10 (2000) **PEER REVIEWED**

M13

EXP SANGSTER (1994)

O13

@ 20 degrees C [Heikes DL; J Assoc Off Anal Chem 70: 215-226 (1987) ]**PEER REVIEWED**

A14

Dichlorodifluoromethane Synonyms: ALGOFRENE TYPE 2 ARCTON 6 DIFLUORODICHLOROMETHANE DWUCHLORODWUFLUOROMETAN ELECTRO-CF 12 ESKIMON 12 F 12 or FC 12 FLUOROCARBON-12 FREON 12 or (F-12) FRIGEN 12 GENETRON 12 HALON ISCEON 122 ISOTRON 12 KAISER CHEMICALS 12 LEDON 12 PROPELLANT 12 R 12 RCRA WASTE NUMBER U075 REFRIGERANT 12 UCON 12/HALOCARBON 12 UN 1028

D14


F14


H14

@ 20 degrees C [Warner MJ, Weiss RF; Deep Sea Res 32A: 1485-97 (1985)]**PEER REVIEWED**

K14

(SRC) determined from a log Kow of 2.16 [Hansch C, Leo A; Exploring QSAR Fundamentals and Applications in Chemistry and Biology. Washington, DC: Amer Chem Soc p. 3 (1995)] and a recommended regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M14


O14

@ 25 degrees C [Flick, E.W. Industrial Solvents Handbook. 3rd ed. Park Ridge, NJ: Noyes Publications, 1985., p. 86]**PEER REVIEWED**

A15

1,1-Dichloroethane Synonyms: HYDROCHLORIC ETHER 1,1-DICHLORETHANE ETHANE, 1,1-DICHLORO- ETHYLIDENE CHLORIDE ETHYLIDENE DICHLORIDE HSDB 64 NCI-C04535 RCRA WASTE NUMBER U076 UN 2362

D15

[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 601]**PEER REVIEWED**

F15

[Lide, DR (ed.). CRC Handbook of Chemistry and Physics. 81st Edition. CRC Press LLC, Boca Raton: FL 2000, p. 3-154]**PEER REVIEWED**

H15


M15


O15

@ 25 degrees C [Horvath A et al; J Phys Chem Ref Data 128: 395-623 (1999)]**PEER REVIEWED**

A16

Dichloroethane, 1,2- Synonyms: Ethane, 1,2-dichloro- Ethylene Dichloride 1,2-DICHLOROETHANE AI3-01656 alpha,beta-DICHLOROETHANE BORER SOL or Brocide Caswell No. 440 CCRIS 225 DESTRUXOL BORER-SOL DI-CHLOR-MULSION Dichlor-Mulsion Dichloremulsion DUTCH LIQUID or Dutch Oil EDC or ENT 1,656 EPA Pesticide Chemical Code 042003 Ethane dichloride Ethane, 1,2-Dichloro- Ethylene chloride Glycol dichloride HSDB 65 NCI-C00511 RCRA WASTE NUMBER U077 sym-DICHLOROETHANE 1,2-BICHLOROETHANE 1,2-DCE or 1,2-DICHLORETHANE 1,2-ETHYLENE DICHLORIDE

D16


F16


H16

@ 25 degrees C [Leighton DT Jr, Calo JM; J Chem Eng 26: 382-5 (1981)]**PEER REVIEWED**

M16


O16


A17

Dichloroethene, 1,1- Synonyms: 1,1-Dichloroethene 1,1-DCE Dichloroethylene, 1,1- Ethylene, 1,1-dichloro- NCI-C54262 RCRA Waste Number U078 Sconatex UN 1303 Vinylidene chloride Vinylidene dichloride Vinylidine chloride VDC 1,1-Dichloroethylene

D17


F17


H17


M17


O17


A18

Dichloroethene, cis - 1,2 Synonyms: Ethene, 1,2-dichloro-, (Z)- (Z)-1,2-Dichloroethene (Z)-1,2-DICHLOROETHYLENE cis-DICHLOROETHYLENE CIS-1,2-DICHLORETHYLENE CIS-1,2-DICHLOROETHENE cis-1,2-DICHLOROETHYLENE Ethene, 1,2-dichloro-, (Z)- Ethylene, 1,2-dichloro-, (Z)- HSDB 5656 or NSC 6149 1,2-CIS-DICHLOROETHYLENE

D18


F18


H18


M18


O18

@ 25 degrees C [Horvath AL et al; J Phys Chem Ref Data 28: 395-627 (1999)]**PEER REVIEWED**

A19

Dichloroethene, trans - 1,2 Synonyms: acetylene dichloride, trans- dichloroethylene, trans- 1,2-Dichloroethylene, trans- ethylene, 1,2-dichloro-, (E)- RCRA waste number U079 trans-acetylene dichloride trans-dichloroethylene trans-1,2-Dichloroethylene

D19


F19


H19

@ 24 degrees C GOSSETT,JM (1987)

M19


O19

@ 25 degrees C [Horvath AL et al; J Phys Chem Ref Data 28: 395-627 (1999)]**PEER REVIEWED**

A20

1,2-Dichloropropane Synonyms: Propane, 1,2-dichloro- Propylene dichloride AI3-15406 alpha,beta-DICHLOROPROPANE alpha,beta-PROPYLENE DICHLORIDE Caswell No. 324 CCRIS 951 or ENT 15,406 EPA Pesticide Chemical Code 029002 HSDB 1102 or NCI-C55141 Propylene chloride

D20


F20

[Lide, D.R. (ed). CRC Handbook of Chemistry and Physics. 72nd ed. Boca Raton, FL: CRC Press, 1991-1992., p. 3-412]**PEER REVIEWED**

H20

@ 25 degrees C [Warner HP et al; Determination of Henry's Law constants of selected priority pollutants. Washington, DC: USEPA/600/D-87/229. NTIS PB87-212684 (1987)]**PEER REVIEWED**

M20

SANGSTER (1994)

O20

@ 25 degrees C [Horvath AL; Halogenated Hydrocarbons. NY, NY: Marcel Dekker p. 740 (1982)]**PEER REVIEWED**

A21

Dichloropropene, 1,3 Synonyms: 3-CHLOROALLYL CHLORIDE alpha-CHLOROALLYL CHLORIDE gamma-CHLOROALLYL CHLORIDE 3-CHLOROPROPENYL CHLORIDE DCP or DICHLOROPROPENE 1,3-DICHLOROPROPENE-1 1,3-Dichloropropene 1,3-DICHLORO-2-PROPENE 1,3-DICHLOROPROPYLENE alpha,gamma-DICHLOROPROPYLENE NCI-C03985 PROPENE, 1,3-DICHLORO- RCRA WASTE NUMBER U084 Telone II

D21


F21

ESTIMATED BY EQUATION 20 IN NEELY,WB & BLAU,GE (1985) SRC.; SYRACUSE RESEARCH CORPORATION CALCULATED VALUES; 1988

H21

@ 20 degrees C [Warner HP et al; Determination of Henry's Law constants of selected priority pollutants. Washington, DC: USEPA/600/D-87/229. NTIS PB87-212684 (1987)]**PEER REVIEWED**

M21

TOMLIN,C (1997);isomer avg

O21

@ 20 degrees C [Dilling WL; Environ Sci Technol 11: 405-9 (1977)]**PEER REVIEWED**

A22

Dioxane, 1,4-Synonyms: diethylene dioxide diethylene oxide Dioxane, 1,4- p-dioxane

D22

[O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 581]**PEER REVIEWED**

F22


H22

@ 25 degrees C [Park JH et al; Anal Chem 59: 1970-1976 (1987) ]**PEER REVIEWED**

K22

Barone FS et al; J Contam Hydrol 10: 225-250 (1992) **PEER REVIEWED**

M22


O22


A23

Ethyl Ether Synonyms: AETHER ANAESTHETIC ETHER ANESTHESIA ETHER ANESTHETIC ETHER DIETHYL ETHER DIETHYL OXIDE ETHANE, 1,1'-OXYBIS- ETHER ETHOXYETHANE ETHYL OXIDE HSDB 70 NSC 100036 3-OXAPENTANE 1,1'-OXYBISETHANE RCRA WASTE NUMBER U117 SOLVENT ETHER UN 1155

D23


F23


H23

@ 25 degrees C [Bocek K; Experientia, Suppl 23: 231-40 (1976)]**QC REVIEWED**

K23

(SRC) determined from a log Kow of 0.89 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Reff Book. Heller SR (consult ed) Washington,DC: Amer Chem Soc p 10 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington,DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M23


O23

@ 25 degrees C [Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 411]**PEER REVIEWED**

A24

Ethylbenzene Synonyms: AETHYLBENZOL EB ETHYLBENZEEN ETHYLBENZOL ETILBENZENE ETYLOBENZEN NCI-C56393 PHENYLETHANE UN 1175

D24


F24


H24

@ 25 degrees [Sanemasa I et al; Bull Chem Soc Japan 55: 1054-62 (1982)]**PEER REVIEWED**

M24


O24

@ 25 degrees C [Sanemasa I et al; Bull Chem Soc Japan 55: 1054-62 (1982)]**PEER REVIEWED**

A25

FORMALDEHYDE Synonyms: BFV & FA FORMALDEHYDE SOLUTION (DOT) FORMALIN & FORMALITH FORMIC ALDEHYDE FORMOL or FYDE HOCH or IVALON KARSAN or LYSOFORM METHANAL METHYL ALDEHYDE METHYLENE GLYCOL METHYLENE OXIDE MORBICID NCI-C02799 OXOMETHANE & OXYMETHYLENE PARAFORM POLYOXYMETHYLENE GLYCOLS RCRA WASTE NUMBER U122 SUPERLYSOFORM UN 1198 (DOT) & UN 2209 (DOT)

D25


F25


H25

@ 25 degrees C [Betterton EA, Hoffmann MR; Environ Sci Technol 22: 1415-8 (1988)]**PEER REVIEWED**

K25

(SRC) determined from a log Kow of 0.35 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 3 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M25


O25

@ 20 degrees C [Pickrell JA et al; Environ Sci Technol 17: 753-7 (1983)]**PEER REVIEWED**

A26

Formic Acid Synonyms: ACIDE FORMIQUE ACIDO FORMICO AMEISENSAEURE AMINIC ACID FORMYLIC ACID HYDROGEN CARBOXYLIC ACID KWAS METANIOWY METHANOIC ACID MIERENZUUR RCRA WASTE NUMBER U123 UN 1779

D26


F26


H26

@ 25 degrees C [Gaffney JS et al; Environ Sci Technol 21: 519-24 (1987) ]**PEER REVIEWED**

K26

(SRC) determined from a log Kow of -0.54 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 3 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M26


O26


A27

Hexane, n Synonyms: AI3-24253 HEXANE HSDB 91 NCI-C60571 SKELLYSOLVE B

D27


F27

[Verschueren, K. Handbook of Environmental Data on Organic Chemicals. Volumes 1-2. 4th ed. John Wiley & Sons. New York, NY. 2001, p. 1269]**PEER REVIEWED**

H27

SRC determined from its vapor pressure of 153 mm Hg(3) and water solubility of 9.5 mg/l [McAuliffe C et al; J Phys Chem 70: 1267-75 (1966)] **PEER REVIEWED**

K27

(SRC) determined from a structure estimation method [Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992)] **PEER REVIEWED**

M27


O27

@ 25 degrees C POLAK,J.; LU,B.C.Y.; MUTUAL SOLUBILITIES OF HYDROCARBONS AND WATER AT 0 AND 25C.; CAN. J. CHEM.; 51:4018-33.; 1973

A28

Isobutyl Alcohol Synonyms: ALCOOL ISOBUTYLIQUE FERMENTATION BUTYL ALCOHOL 1-HYDROXYMETHYLPROPANE ISOBUTANOL ISOBUTYLALKOHOL ISOPROPYLCARBINOL 2-METHYL PROPANOL 2-METHYL-1-PROPANOL 2-METHYLPROPYL ALCOHOL 1-PROPANOL, 2-METHYL- RCRA WASTE NUMBER U140 UN 1212

D28


F28


H28

@ 25 degrees C [Snider JR, Dawson; J Geophys Res 90: 3797-3805 (1985)]**PEER REVIEWED**

K28

(SRC) determined from a log Kow of 0.76 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 10 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M28


O28

@ 25 degrees C [Valvani SC et al; J Pharm Sci 70: 502-7 (1981)]**PEER REVIEWED**

A29

Methanol Synonyms: carbinol methyl alcohol wood alcohol wood-spirit

D29


F29


H29

@ 25 degrees C [Gaffney JS et al; Environ Sci Technol 21: 519-23 (1987)]**PEER REVIEWED**

K29

SRC determined from a structure estimation method [Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992)] **PEER REVIEWED**

M29


O29


A30

MEK Synonyms: aethylmethylketon 2-butanone butanone-2 ethyl methyl cetone ethylmethylketon ethyl methyl ketone ketone, ethyl methyl meetco methyl acetone metiletilchetone metyloetyloketon RCRA waste number U159 UN 1193 or UN 1232

D30


F30


H30

@ 25 degrees C [Bhattacharaya SK et al; Water Res 30: 3099-3105 (1996)]**PEER REVIEWED**

K30

Average from range of 29 to 34 obtained in silt loams [Walton BT et al; J Environ Qual 21: 552-58 (1992)] **PEER REVIEWED**

M30


O30


A31

MIBK or MIK Synonyms: HEXON or HEXONE ISOBUTYL-METHYLKETON ISOBUTYL METHYL KETONE ISOPROPYLACETONE KETONE, ISOBUTYL METHYL METHYL-ISOBUTYL-CETONE METHYLISOBUTYLKETON 4-METHYL-PENTAN-2-ON 2-METHYL-4-PENTANONE 4-METHYL-2-PENTANONE METILISOBUTILCHETONE 4-METILPENTAN-2-ONE METYLOIZOBUTYLOKETON 2-PENTANONE, 4-METHYL- RCRA WASTE NUMBER U161 SHELL MIBK or UN 1245

D31


F31

[Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 771]**PEER REVIEWED**

H31

SRC determined from an experimental vapor pressure of 19.9 mm Hg at 25 deg C [Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals: Data Compilation. NY,NY: Hemisphere Pub Corp (1989)] and water solubility of 19,000 mg/l at 25 deg C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Ver 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)] **PEER REVIEWED**

K31

SRC determined from an experimental log Kow of 1.31 [Hansch C et al; Exploring QSAR Hydrophobic, Electronic and Stearic Constants Washington,DC: Amer Chem Soc (1995)] and a recommended regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington,DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M31


O31

@ 25 degrees [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)]**PEER REVIEWED**

A32

MTBE Synonyms: Propane, 2-methoxy-2-methyl- methyl tert-butyl ether T-BUTYL METHYL ETHER Ether, tert-butyl methyl HSDB 5847 METHYL 1,1-DIMETHYLETHYL ETHER Methyl-tert-butylether Metil-terc-butileter [Spanish] tert-Butyl methyl ether 2-METHOXY-2-METHYLPROPANE 2-METHYL-2-METHOXYPROPANE

D32


F32


H32

@ 25 degrees [Hine J and Mookerjee PK; J Org Chem 40: 292-8 (1975)]**PEER REVIEWED**

K32

SRC [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington,DC: Amer Chem Soc pp. 4-4, 4-9, 5-4, 5-10, 15-1 to 15-29 (1990)] calculated from a soil/water partition coefficient of 0.0925 [Shaffer KL and Uchrin CG; Bull Environ Contam Toxicol 59: 744-9 (1997)] **PEER REVIEWED**

M32


O32


A33

Methylene Chloride Synonyms: Aerothene MM Chlorure de methylene DCM Dichlormethan, uvasol Dichloromethane 1,1-Dichloromethane. Freon 30 Methane dichloride Methane, dichloro- Methylene bichloride Methylene dichloride Narkotil NCI-C50102 R 30 or Solaesthin Solmethine or WLN: G1G

D33


F33


H33

@ 24.8 degrees C GOSSETT,J.M.; MEASUREMENT OF HENRY'S LAW CONSTANT FOR C1 AND C2 CHLORINATED HYDROCARBONS; ENVIRON SCI TECH; 21:202-6; 1987

M33


O33

@ 25 degrees C [Horvath AL; Halogenated Hydrocarbons: Solubility-Miscibility With Water NY: Marcel Dekker (1982)]**PEER REVIEWED**

A34

Styrene Synonyms: BENZENE, VINYL- CINNAMENE CINNAMENOL CINNAMOL DIAREX HF 77 ETHENYLBENZENE ETHYLENE, PHENYL- NCI-C02200 PHENETHYLENE PHENYLETHENE PHENYLETHYLENE STIROLO STYREEN STYREN STYRENE, MONOMER STYROL STYROLE STYROLENE STYROPOL STYROPOR UN 2055

D34


F34


H34

@ 25 degrees C [Bocek K; Experimetia, Suppl 23: 231-40 (1976)]**PEER REVIEWED**

M34


O34

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; AQUASOL dATAbASE of Aqueous Solubility. 5th ed. Tucson, AZ: Univ of Arizona, College of Pharmacy (1990)]**PEER REVIEWED**

A35

Tetrachloroethane, 1,1,1,2-Synonyms: ETHANE, 1,1,1,2-TETRACHLORO- Ethane, 1,1,1,2-tetrachloro- (8CI)(9CI) HSDB 4148 or NCI-C52459 RCRA WASTE NUMBER U208

D35

[Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 75th ed. Boca Raton, Fl: CRC Press Inc., 1994-1995., p. 3-156]**PEER REVIEWED**

F35


H35

@ 25 degrees C SANDER,R (1999)

K35

Values were taken from http://www.epa.gov/oppt/exposure/docs/episuitedl.htm.The Soil Adsorption Coefficient Program (PCKOCWIN) estimates the soil adsorption coeffiecient (Koc) of organic compounds. Koc can be defined as "the ratio of the amount of chemical adsorbed per unit weight of organic carbon (oc) in the soil or sediment to the concentration of the chemical in solution at equilibrium"; it is represented by the following equation: Koc = (ug adsorbed/g organic carbon) / (ug/mL solution) Please consult the Meylan et al. 1992 article for complete description of the estimation methodology used by PCKOCWIN. Briefly, the general equation used to estimate log Koc of any compound is: log Koc = 0.53 MCI + 0.62 + Summation (Pf) where MCI is the first order molecular connectivity index and Summation (Pf) is the summation product of all applicable correction factors. A list of the correction factors is presented in Appendix D. See Appendix E, Appendix F and Appendix G for lists of the chemicals used in the regressions and a supplemental validation list. Appendixies are in the help files of the software.

M35

MEYLAN,WM & HOWARD,PH (1995)

O35


A36

Tetrachloroethane, 1,1,2,2- Synonyms: ACETYLENE TETRACHLORIDE BONOFORM CELLON 1,1,2,2-CZTEROCHLOROETAN 1,1-DICHLORO-2,2-DICHLOROETHANE ETHANE, 1,1,2,2-TETRACHLORO- NCI-C03554 RCRA WASTE NUMBER U209 TCE 1,1,2,2-TETRACHLOORETHAAN 1,1,2,2-TETRACHLORAETHAN TETRACHLORETHANE sym-TETRACHLOROETHANE TETRACHLORURE D'ACETYLENE 1,1,2,2-TETRACLOROETANO UN 1702 WESTRON

D36


F36


H36

@ 25 degrees C [Leighton DT Jr, Calo JM; J Chem Eng 26: 382-5 (1981) ]**PEER REVIEWED**

M36


O36

@ 20 degrees C [Verschueren, K. Handbook of Environmental Data on Organic Chemicals. Volumes 1-2. 4th ed. John Wiley & Sons. New York, NY. 2001, p. 1946]**PEER REVIEWED**

A37

Tetrachloroethene Synonyms: Ankilostin Antisal 1 or Antisol 1 Carbon bichloride Carbon dichloride Czterochloroetylen Dee-Solv Didakene or Didokene Dowclene EC Dow-Per ENT 1,860 Ethene, tetrachloro- Ethylene tetrachloride Ethylene, tetrachloro- Fedal-Un NCI-C04580 Nema PCE PER Perawin PERC Perchloorethyleen, per Perchlor Perchloraethylen, per Perchlorethylene Perchlorethylene, per Perchloroethylene Perclene Percloroetilene Percosolv Percosolve PERK Perklone Persec Tetlen Tetracap Tetrachlooretheen Tetrachloraethen Tetrachlorethylene Tetrachloroethene Tetrachloroethylene 1,1,2,2-Tetrachloroethylene. Tetracloroetene Tetraguer or Tetraleno Tetralex or Tetravec Tetroguer Tetropil WLN: GYGUYGG

D37


F37


H37

@ 25 degrees C [Gossett JM; Environ Sci Technol 21: 202-6 (1987)]**PEER REVIEWED**

M37


O37


A38

Toluene Synonyms: ANTISAL 1a BENZENE, METHYL METHACIDE METHYL-BENZENE METHYLBENZOL NCI-C07272 PHENYL-METHANE RCRA WASTE NUMBER U220 TOLUEEN or TOLUEN TOLUOL or TOLUOLO TOLU-SOL UN 1294

D38


F38


H38

@ 25 degrees C [Mackay D et al; Environ Sci Technol 13: 333-6 (1979)]**PEER REVIEWED**

M38


O38


A39

Trichloroethane 1,1,1- Synonyms: AEROTHENE TT CHLOROETENE CHLOROETHENE CHLOROETHENE NU CHLOROFORM, METHYL- CHLOROTHANE NU CHLOROTHENE CHLOROTHENE NU CHLOROTHENE VG CHLORTEN ETHANE, 1,1,1-TRICHLORO- INHIBISOL METHYLCHLOROFORM METHYLTRICHLOROMETHANE NCI-C04626 RCRA WASTE NUMBER U226 STROBANE alpha-T 1,1,1-TCE 1,1,1-TRICHLOORETHAAN 1,1,1-TRICHLORAETHAN alpha-TRICHLOROETHANE 1,1,1-TRICLOROETANO TRI-ETHANE UN 2831

D39


F39


H39

@ 24 degrees C GOSSETT,JM (1987)

M39


O39


A40

Trichloroethane, 1,1,2-Synonyms: ETHANE TRICHLORIDE ETHANE, 1,1,2-TRICHLORO- NCI-C04579 RCRA WASTE NUMBER U227 RCRA WASTE NUMBER U359 beta-T 1,1,2-TRICHLORETHANE 1,2,2-TRICHLOROETHANE beta-TRICHLOROETHANE TROJCHLOROETAN(1,1,2) VINYL TRICHLORIDE

D40


F40


H40

@ 25 degrees C [Leighton DT, Calo JM; J Chem Eng 26: 382-5 (1981)]**PEER REVIEWED**

M40


O40


A41

Trichloroethene Synonyms: ACETYLENE TRICHLORIDE ALGYLEN ANAMENTH BENZINOL BLACOSOLV BLANCOSOLV CECOLENE CHLORILEN 1-CHLORO-2,2-DICHLOROETHYLENE CHLORYLEA CHLORYLEN CHORYLEN CIRCOSOLV CRAWHASPOL DENSINFLUAT 1,1-DICHLORO-2-CHLOROETHYLENE DOW-TRI DUKERON ETHINYL TRICHLORIDE ETHYLENE TRICHLORIDE ETHYLENE, TRICHLORO- FLECK-FLIP FLOCK FLIP FLUATE GEMALGENE GERMALGENE LANADIN LETHURIN NARCOGEN NARKOGEN NARKOSOID NCI-C04546 NIALK PERM-A-CHLOR PERM-A-CLOR PETZINOL PHILEX RCRA WASTE NUMBER U228 TCE THRETHYLEN THRETHYLENE TRETHYLENE TRI or TRIAD or TRIAL TRIASOL TRICHLOORETHEEN TRICHLOORETHYLEEN, TRI TRICHLORAETHEN TRICHLORAETHYLEN, TRI TRICHLORAN or TRICHLOREN TRICHLORETHYLENE, TRI TRICHLOROETHENE Trichloroethylene 1,1,2-TRICHLOROETHYLENE 1,2,2-TRICHLOROETHYLENE TRI-CLENE TRICLORETENE TRICLOROETILENE TRIELENE or TRIELIN TRIELINA or TRIKLONE TRILEN or TRILENE TRILINE or TRIMAR TRIOL or TRI-PLUS TRI-PLUS M UN 1710 VESTROL VITRAN WESTROSOL

D41


F41


H41

@ 25 degrees C MUNZ,C.; ROBERTS,P.V.; AIR-WATER PHASE EQUILIBRIA OF VOLATILE ORGANIC SOLUTES.; J. - AM. WATER WORKS ASSOC.; 79:62-9; 1987

M41


O41

@ 25 degrees C [Horvath AL et al; J Phys Chem Ref Data 28: 449 (1999)]**PEER REVIEWED**

A42

Trichlorofluoromethane synonyms: ALGOFRENE TYPE 1 ARCTON 9 ELECTRO-CF 11 ESKIMON 11 F 11 or FC 11 FLUOROCARBON NO. 11 FLUOROTRICHLOROMETHANE FLUOROTROJCHLOROMETAN FREON 11 FREON 11A or FREON 11B FREON HE pr FREON MF FRIGEN 11 GENETRON 11 HALOCARBON 11 ISCEON 131 or ISOTRON 11 LEDON 11 MONOFLUOROTRICHLOROMETHANE NCI-C04637 RCRA WASTE NUMBER U121 TRICHLOROMONOFLUOROMETHANE UCON FLUROCARBON 11 UCON REFRIGERANT 11

D42


F42


H42

@ 25 degrees C [Warner MJ, Weiss RF; Deep Sea Res A 32: 1485-97 (1985)]**PEER REVIEWED**

K42

SRC determined from a measured water solubility of 1,100 [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Ver 5. Tucson, AZ: Univ AZ, College of Pharmacy (1992)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-5 (1990)] **PEER REVIEWED**

M42


O42

@ 20 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Ver 5. Tucson, AZ: Univ AZ, College of Pharmacy (1992)]**PEER REVIEWED**

A43

Trichloropropane, 1,2,3 Synonyms: ALLYL TRICHLORIDE GLYCEROL TRICHLOROHYDRIN GLYCERYL TRICHLOROHYDRIN NCI-C60220 PROPANE, 1,2,3-TRICHLORO- TRICHLOROHYDRIN

D43

[Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989., p. ]**PEER REVIEWED**

F43

[Daubert, T.E., R.P. Danner. Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C.: Taylor and Francis, 1989., p. ]**PEER REVIEWED**

H43

[Leighton DTJr, Calo JM; J Chem Eng 26: 382-5 (1981)]**PEER REVIEWED**

K43

Average of range from 77-95 Walton DJ et al; J Environ Qual 21: 552-8 (1992) **PEER REVIEWED**

M43

CHEM INSPECT TEST INST (1992)

O43

@ 25 degrees C [Albanese V et al; Env Tech Lett 59: 1419-56 (1987)]**PEER REVIEWED**

A44

Vinyl Chloride Synonyms: vinyl chloride monomer chloroethylene chloroethene VC or VCM

D44


F44


H44

@ 25 degrees C [Gossett JM; Environ Sci Technol 21: 202-6 (1987)]**PEER REVIEWED**

M44


O44

[Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. 1325]**PEER REVIEWED**

A45

Xylenes, Total Synonyms: 108-38-3 1330-20-7 106-42-3 95-47-6 dimethylbenzene 1,2-dimethylbenzene 1,3-dimethylbenzene 1,4-dimethylbenzene mixed xylenes m-xylene or meta-xylene o-xylene or ortho-xylene p-xylene or para-xylene

D45


F45

Values were taken from http://www.epa.gov/oppt/exposure/docs/episuitedl.htm. MPBPWIN, from Syracuse Research Corporation, retrieves melting point values from a database containing reliably measured values. When a structure matches a database structure (via an exact atom-to-atom connection match), the melting point experimental value is retrieved. If no experimental value is availbale, an estimated values is generated. Used for organic compounds only.

H45

Smith JR et al; Water Environ Res 65: 804-818 (1993) **QC REVIEWED**

K45

Average of range from 39 to 2600 Pavlostathis SG, Mathavan GN; Environ Sci Technol 26: 532-538 (1992) Seip HM et al; Sci Total Environ 50: 87-101 (1986)

M45

HANSCH,C & LEO,AJ (1985)

O45

@ 25 degrees C YALKOWSKY,SH & DANNENFELSER,RM (1992)

A47

Acenaphthene Synonyms: Acenaphthylene, 1,2-dihydro- HSDB 2659 Naphthyleneethylene NSC 7657 PERI-ETHYLENENAPHTHALENE 1,2-DIHYDROACENAPHTHYLENE 1,8-ETHYLENENAPHTHALENE

D47

[The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 5]**PEER REVIEWED**

F47


H47

@ 25 degrees C BAMFORD,HA ET AL. (1999)

M47


O47

@ 25 degrees C MILLER,MM ET AL. (1985)

A48

Acetophenone Synonyms: acetyl benzene hypnone phenyl methyl acetone

D48


F48


H48

[Betterton EA et al; Atmos Environ 25A: 1473-77 (1991)]**PEER REVIEWED**

K48

Ding Y, Wang L; Toxicol Environ Chem 78: 1-9 (2000) **PEER REVIEWED**

M48


O48

@ 25 degrees C [Southworth GR, Keller JL; Water Air Soil Poll 28: 239-48 (1986)]**PEER REVIEWED**

A49

Acrylonitrile Synonyms: ACRITET ACRYLNITRIL ACRYLON ACRYLONITRILE MONOMER AKRYLONITRYL CARBACRYL CIANURO DI VINILE CYANOETHYLENE CYANURE DE VINYLE ENT 54 FUMIGRAIN MILLER'S FUMIGRAIN NITRILE ACRILICO NITRILE ACRYLIQUE PROPENENITRILE 2-PROPENENITRILE RCRA WASTE NUMBER U009 TL 314 UN 1093 VCN VENTOX VINYL CYANIDE

D49


F49

[Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 18]**PEER REVIEWED**

H49

@ 25 degrees C [Bocek K; Experientia Suppl 23: 231-40 (1976)]**PEER REVIEWED**

K49

SRC determined from a log Kow of 0.25 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 5 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M49


O49

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth Ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)]**PEER REVIEWED**

A50

Aniline Synonyms: aminobenzene aminophen aniline-oil kyanol phenylamine

D50


F50


H50

@ 25 degrees C [Jayasinghe DS et al; Environ Sci Technol 26: 2275-81 (1992)]**PEER REVIEWED**

K50

Average of range from 43.8 to 497.7 Gawlik BM et al; Chemosphere 36: 2903-19 (1998) **PEER REVIEWED**

M50


O50

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)]**PEER REVIEWED**

A51

ANTHRACENE Synonyms: ANTHRACIN GREEN OIL HSDB 702 NSC 7958 PARANAPHTHALENE TETRA OLIVE N2G

D51


F51


H51

@ 25 degrees C [Alaee M et al; Chemosphere 32: 1153-64 (1996)]**PEER REVIEWED**

M51


O51

@ 25 deg C in distilled water [Verschueren, K. Handbook of Environmental Data on Organic Chemicals. 3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996., p. 209]**PEER REVIEWED**

A52

Benzidine Synonyms: BENZIDIN BENZIDINA BENZYDYNA 4,4'-BIANILINE p,p'-BIANILINE (1,1'-BIPHENYL)-4,4'-DIAMINE 4,4'-BIPHENYLDIAMINE BIPHENYL, 4,4'-DIAMINO- 4,4'-BIPHENYLENEDIAMINE C.I. 37225 C.I. AZOIC DIAZO COMPONENT 112 4,4'-DIAMINOBIPHENYL 4,4'-DIAMINO-1,1'-BIPHENYL p,p'-DIAMINOBIPHENYL 4,4'-DIAMINODIPHENYL p-DIAMINODIPHENYL p,p'-DIANILINE 4,4'-DIPHENYLENEDIAMINE FAST CORINTH BASE B NCI-C03361 RCRA WASTE NUMBER U021 UN 1885

D52

[ATSDR; Toxicological Profile for Benzidine (Update). Prepared for: US Dept Health and Human Services Public Health Services. Agency for Toxic Substances and Disease Registry p. 113 (2000)]**QC REVIEWED**

F52

[ATSDR; Toxicological Profile for Benzidine (Update). Prepared for: US Dept Health and Human Services Public Health Services. Agency for Toxic Substances and Disease Registry p. 113 (2000)]**QC REVIEWED**

H52

SRC developed using a fragment constant estimation method [Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991)] **QC REVIEWED**

K52

Arage of range from 2.27E+05 to 8.82E+05 Graveel JG et al; J Environ Qual 15: 53-9 (1986) **QC REVIEWED**

M52


O52

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Ver 5. Tucson, AZ: Univ AZ, College of Pharmacy (1992)]**QC REVIEWED**

A53

Benzo(a)anthracene Synonyms: Benzanthracene Benzanthrene BENZO(b)PHENANTHRENE Benzoanthracene HSDB 4003 or NSC 30970 RCRA WASTE NUMBER U018 Tetraphene 1,2-BENZ(a)ANTHRACENE 1,2-Benzanthracene 1,2-BENZANTHRENE 1,2-BENZOANTHRACENE 2,3-Benzophenanthrene

D53


F53


H53


M53


O53


A54

Benzo[a]pyrene Synonyms: BaP or B(a)P BENZO(d,e,f)CHRYSENE 3,4-BENZOPIRENE 3,4-BENZOPYRENE 6,7-BENZOPYRENE 3,4-BENZPYREN 3,4-BENZPYRENE 3,4-BENZ(a)PYRENE BENZ(a)PYRENE 3,4-BENZYPYRENE BP or 3,4-BP RCRA WASTE NUMBER U022

D54


H54

@ 25 degrees C [Ten Hulscher TEM et al; Environ Toxicol Chem 11: 1595-603 (1992)]**PEER REVIEWED**

M54

DE MAAGD,PG ET AL. (1998)

O54


A55

Benzo(b)fluoranthene Synonyms: Benz(e)acephenanthrylene B(b)F BENZ(e)ACEPHENANTHRYLENE Benzo(e)fluoranthene HSDB 4035 NSC 89265 2,3-BENZFLUORANTHENE 2,3-BENZOFLUORANTHENE 2,3-BENZOFLUORANTHRENE 3,4-BENZ(e)ACEPHENANTHRYLENE 3,4-BENZFLUORANTHENE 3,4-Benzofluoranthene

D55


F55


H55

TEM et al; Environ Toxicol Chem 11: 1595-1603 (1992) **PEER REVIEWED**

M55

[Meador JP et al; Rev Environ Contam Toxicol 143: 79-165 (1995)]**PEER REVIEWED**

O55

[Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)]**PEER REVIEWED**

A56

Benzo(k)fluoranthene Synonyms: Dibenzo(b,jk)fluorene HSDB 6012 11,12-BENZO(k)FLUORANTHENE 11,12-Benzofluoranthene 2,3,1',8'-Binaphthylene 8,9-BENZOFLUORANTHENE

D56

[Weast, R.C. (ed.) Handbook of Chemistry and Physics. 69th ed. Boca Raton, FL: CRC Press Inc., 1988-1989., p. C-126]**PEER REVIEWED**

F56


H56


M56


O56

@ 25 degrees C [Pearlman RS et al; J Chem Ref Data 13: 555-62 (1984)]**PEER REVIEWED** Water solubility: 0.00076 ppm at 25 deg C. [USEPA; Health and Environmental Effects Profile for Benzo(k)fluoranthene p.4 (1987) ECAO-CIN-P229]**PEER REVIEWED**

A57

VAP: Same as Di (2-ethylhexyl) Phthalate (DEHP).

D57


F57


H57

SRC estimated from its experimental values for vapor pressure, 7.23X10-8 mm Hg(4) and water solubility, 0.285 mg/l [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Ver 5. College of Pharmacy, Univ of Ariz - Tucson, AZ. PC Ver (1992)] **PEER REVIEWED**

M57

DEBRUIJN,J ET AL. (1989)

O57


A58

Butyl Benzyl Phthalate Synonyms: BBP 1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER BENZYL-BUTYLESTER KYSELINY FTALOVE BENZYL BUTYL PHTHALATE BENZYL n-BUTYL PHTHALATE n-BUTYL BENZYL PHTHALATE BUTYL PHENYLMETHYL 1,2-BENZENEDICARBOXYLATE NCI-C54375 PALATINOL BB PHTHALIC ACID, BENZYL BUTYL ESTER SANTICIZER 160 SICOL 160 UNIMOLL BB

D58

[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 401]**PEER REVIEWED**

F58

[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V29 193 (1982)]**PEER REVIEWED**

H58

SRC determined from a measured vapor pressure of 8.25X10-6 mm Hg at 25 deg C [Howard PH et al; Environ Toxicol Chem 4: 653-61(1985)] and water solubility of 0.71 mg/l at 25 deg C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)] **PEER REVIEWED**

M58

ELLINGTON,JT & FLOYD,TL (1996)

O58

[Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)]**PEER REVIEWED**

D59


F59


H59

@ 25 degrees C [Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991)]**PEER REVIEWED**

M59


O59

@ 25 degrees C AINSWORTH,CC ET AL. (1989)

A60

Chlordane Synonyms: Belt CD 68 Chlorindan Chlor Kil Corodan Dowchlor ENT 9, 932 HCS 3260 Kypchlor M 140 or M 410 4,7-Methanoindan, 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a- Tetrahydro- 4,7-Methano-1H-Indene, 1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7, 7a-Hexahydro- NCI-C00099 Niran Octachlorodihydrodicyclopentadiene 1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-Hexahydro-4, 7- Methano-indene 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-Hexahydro-4,7-Methylene Indane Octachloro-4, 7-Methanohydroindane Octachloro-4, 7-Methanotetrahydroindane Octa-Klor or Oktaterr Ortho-Klor or Synklor TAT Chlor 4 Topiclor or Toxichlor Velsicol 1068

B60

VAP: This CAS # has also been recorded as 54-74-9 in some sources, however SSG, TOXNET and Howard all list it as 57-74-9

D60

[SRI International. 2001 Directory of Chemical Producers. SRI Consulting, Menlo Park, CA. 2001., p. 438]**PEER REVIEWED**

H60

@ 25 degrees C [Warner HP et al; Determination of Henry's Law Constants of Selected Priority Pollutants; EPA/600/d-87/229; NTIS PB87-212684 (1987)]**PEER REVIEWED**

M60

SIMPSON,CD ET AL. (1995)

O60

@ 25 degrees C [Sanborn JR; Entomology 5:533-38 (1976) ]**PEER REVIEWED**

A61

Chrysene Synonyms: BENZ(a)PHENANTHRENE BENZO(a)PHENANTHRENE HSDB 2810 NSC 6175 RCRA WASTE NUMBER U050 1,2-BENZOPHENANTHRENE 1,2-BENZPHENANTHRENE 1,2,5,6-DIBENZONAPHTHALENE

D61


F61


H61


M61


O61

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, Univ of Ariz - Tucson, AZ. PC Version (1992)] **PEER REVIEWED**

A62

Dibenz(a,h)anthracene Synonyms: DB(a,h)A DBA DIBENZO(a,h)ANTHRACENE HSDB 5097 NSC 22433 RCRA WASTE NUMBER U063 1,2,5,6-DIBENZANTHRACEEN [Dutch] 1,2,5,6-dibenzanthracene 1,2:5,6-BENZANTHRACENE 1,2:5,6-DIBENZ(a)ANTHRACENE 1,2:5,6-Dibenzanthracene 1,2:5,6-DIBENZOANTHRACENE

D62


F62


H62

SRC estimated using a fragment constant estimation method [Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991)] **PEER REVIEWED**

M62


O62


A63

Dichlorobenzene, 1,2 Synonyms: BENZENE, 1,2-DICHLORO- BENZENE, o-DICHLORO- CHLOROBEN or CHLORODEN CLOROBEN DCB o-DICHLORBENZENE o-DICHLOR BENZOL o-DICHLOROBENZENE 1,2-DICHLOROBENZENE o-DICHLOROBENZENE DICHLOROBENZENE, ORTHO DILANTIN DB or DILATIN DB DIZENE DOWTHERM E NCI-C54944 ODB or ODCB ORTHODICHLOROBENZENE ORTHODICHLOROBENZOL SPECIAL TERMITE FLUID TERMITKIL UN 1591

D63


F63


H63


M63


O63


A64

1,4-DICHLOROBENZENE Synonyms: BENZENE, 1,4-DICHLORO- BENZENE, P-DICHLORO- CASWELL NO. 632 DI-CHLORICIDE DICHLOROBENZENE, PARA EPA PESTICIDE CHEMICAL CODE 061501 EVOLA HSDB 523 NCI-C54955 NSC 36935 PARADI PARADICHLOROBENZENE PARADICHLOROBENZOL PARADOW PARAMOTH PARAZENE P-CHLOROPHENYL CHLORIDE PDB P-DICHLOROBENZENE P-DICHLOROBENZOL PERSIA-PERAZOL RCRA WASTE NUMBER U070 & U072 SANTOCHLOR UN 1592

D64


F64


H64


M64


O64


A65

Dichlorobenzidine, 3,3 Synonyms: BENZIDINE, 3,3'-DICHLORO- (1,1'-BIPHENYL)-4,4'-DIAMINE, 3,3'-DICHLORO- C.I. 23060 CURITHANE C 126 4,4'-DIAMINO-3,3'-DICHLOROBIPHENYL 3,3'-DICHLORBENZIDIN [CZECH] 3,3'-DICHLOROBENZIDINA [SPANISH] 3,3'-DICHLOROBENZIDIN [CZECH] DICHLOROBENZIDINE DICHLOROBENZIDINE BASE O,O'-DICHLOROBENZIDINE 3,3'-DICHLORO-(1,1'-BIPHENYL)-4,4'-DIAMINE 3,3'-DICHLORO-4,4'-BIPHENYLDIAMINE 3,3'-DICHLOROBIPHENYL-4,4'-DIAMINE 3,3'-DICHLORO-4,4'-DIAMINOBIPHENYL HSDB 1632 NSC 154073 RCRA WASTE NUMBER U073

D65


F65


H65

SRC developed using a fragment constant estimation method [Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991)] **PEER REVIEWED**

M65


O65

@ 25 degrees C [Banerjee S et al; Environ Sci Technol 14: 1227-29 (1980)]**PEER REVIEWED**

A66

DDD Synonyms: 1,1-bis(4-chlorophenyl)-2,2-dichloroethane 1,1-bis(p-chlorophenyl)-2,2-dichloroethane 2,2-bis(p-chlorophenyl)-1,1-dichloroethane DDD or 4,4'-DDD or p,p'-DDD 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane dichlorodiphenyl dichloroethane Dichlorodiphenyl dichloroethane, p,p'- dilene or rothane TDE or p,p'-TDE

D66


H66

@ 25 degrees C [Altschuh J et al; Chemosphere 39: 1871-87 (1999)]**PEER REVIEWED**

M66

SANGSTER (1994)

O66

water at 24 deg C /99% purity [Verschueren, K. Handbook of Environmental Data on Organic Chemicals. 3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996., p. 587]**PEER REVIEWED**

A67

DDE Synonyms: 2,2-BIS(4-CHLOROPHENYL)-1,1-DICHLOROETHENE 2,2-BIS(p-CHLOROPHENYL)-1,1-DICHLOROETHYLENE p,p'-DDE DDT DEHYDROCHLORIDE 1,1-DICHLORO-2,2-BIS(p-CHLOROPHENYL)ETHYLENE DICHLORODIPHENYLDICHLOROETHYLENE Dichlorodiphenyldichloroethylene, p,p'- 1,1'-DICHLOROETHENYLIDENE)BIS(4-CHLOROBENZENE) ETHYLENE, 1,1-DICHLORO-2,2-BIS(p-CHLOROPHENYL)- NCI-C00555

D67


F67


H67


M67

[Sangster J; LOGKOW Databank. Sangster Res. Lab., Montreal Quebec, Canada (1994)]**PEER REVIEWED**

O67


A68

DDT Synonyms: AGRITAN or ANOFEX ARKOTINE or AZOTOX BENZENE, 1,1'-(2,2,2-TRICHLOROETHYLIDENE)BIS(4-CHLORO-) alpha,alpha-BIS(p-CHLOROPHENYL)-beta,beta,beta-TRICHLORETHANE 1,1-BIS-(p-CHLOROPHENYL)-2,2,2-TRICHLOROETHANE 2,2-BIS(p-CHLOROPHENYL)-1,1,1-TRICHLOROETHANE BOSAN SUPRA or BOVIDERMOL CHLOROPHENOTHAN or CHLOROPHENOTHANE CHLOROPHENOTOXUM CITOX or CLOFENOTANE p,p'-DDT DEDELO or DEOVAL DETOX or DETOXAN DIBOVAN DICHLORODIPHENYLTRICHLOROETHANE 4,4'-DICHLORODIPHENYLTRICHLOROETHANE Dichlorodiphenyltrichloroethane, p,p'- DICOPHANE DIDIGAM or DIDIMAC DIPHENYLTRICHLOROETHANE DODAT or DYKOL ENT 1,506 or ESTONATE ETHANE, 1,1,1-TRICHLORO-2,2-BIS(p-CHLOROPHENYL)- GENITOX GESAFID or GESAPON GESAREX or GESAROL GUESAPON or GUESAROL GYRON HAVERO-EXTRA HILDIT IVORAN or IXODEX KOPSOL MICRO DDT 75 MUTOXIN NA 2761 NCI-C00464 NEOCID PARACHLOROCIDUM PEB1 PENTACHLORIN or PENTECH PPZEIDAN R50 RCRA WASTE NUMBER U061 RUKSEAM SANTOBANE TECH DDT 1,1,1-TRICHLOOR-2,2-BIS(4-CHLOOR FENYL)-ETHAAN 1,1,1-TRICHLOR-2,2-BIS(4-CHLOR-PHENYL)-AETHAN 1,1,1-TRICHLORO-2,2-BIS(p-CHLOROPHENYL)ETHANE TRICHLOROBIS(4-CHLOROPHENYL)ETHANE 1,1,1-TRICHLORO-2,2-DI(4-CHLOROPHENYL)-ETHANE 1,1,1-TRICLORO-2,2-BIS(4-CLORO-FENIL)-ETANO ZEIDANE or ZERDANE

D68


F68


H68


M68


O68


A69

Dichlorophenoxyacetic acid, 2,4 Synonyms: ACETIC ACID, (2,4-DICHLOROPHENOXY)- ACIDE 2,4-DICHLORO PHENOXYACETIQUE ACIDO(2,4-DICLORO-FENOSSI)-ACETICO AGROTECT AMIDOX or AMOXONE AQUA-KLEEN BH 2,4-D BRUSH-RHAP B-SELEKTONON CHLOROXONE CROP RIDER CROTILIN 2,4-D D 50 DACAMINE 2,4-D ACID DEBROUSSAILLANT 600 DECAMINE DED-WEED LV-69 DESORMONE (2,4-DICHLOOR-FENOXY)-AZIJNZUUR DICHLOROPHENOXYACETIC ACID 2,4-DICHLORPHENOXYACETIC ACID (2,4-DICHLOR-PHENOXY)-ESSIGSAEURE DICOPUR or DICOTOX DINOXOL DMA-4 or DORMONE 2,4-DWUCHLOROFENOKSYOCTOWY KWAS EMULSAMINE BK or EMULSAMINE E-3 ENT 8,538 ENVERT 171 or ENVERT DT ESTERON or ESTERONE FOUR ESTONE FARMCO FERNESTA or FERNIMINE FERNOXONE or FERXONE FOREDEX 75 or FORMULA 40 HEDONAL or HERBIDAL IPANER KROTILINE LAWN-KEEP MACRONDRAY or MIRACLE MONOSAN or MOXONE NA 2765 NETAGRONE or NETAGRONE 600 NSC 423 PENNAMINE or PENNAMINE D PHENOX PIELIK PLANOTOX PLANTGARD RCRA WASTE NUMBER U240 RHODIA SALVO SPRITZ-HORMIN/2,4-D or SPRITZ-HORMIT/2,4-D TRANSAMINE TRIBUTON or TRINOXOL U 46DP or U-5043 VERGEMASTER VIDON 638 or VISKO-RHAP WEED-AG-BAR or WEEDAR-64 WEEDATUL or WEED-B-GON WEEDEZ WONDER BAR WEEDONE LV4 or WEED-RHAP WEED TOX or WEEDTROL

D69


F69


H69

@ 20 degrees C [Rice CP et al; J Agric Food Chem 45: 2291-8 (1997)]**PEER REVIEWED**

K69

Average of range from 20 to 136 Rao PSC, Davidson JM; Retention and Transformation of Selected Pesticides and Phosphorous in Soil-Water Systems: A Critical Review. USEPA-600/S3-82-060 (1982) Davidson JM et al; p. 16 in Adsorption, Movement and Biological Degradation of Large Concns of Pesticides in Soils. USEPA-600/2-80-124 (1980) USDA; ARS Pesticide Properties Database (Oct 1, 2001). Available at http://www.arsusda.gov/acsl/services/ppdb/ppdb3.html as of Nov 26, 2001. **PEER REVIEWED**

M69


O69


A70

Diethyl Phthalate Synonyms: ANOZOL 1,2-BENZENEDICARBOXYLIC ACID, DIETHYL ESTER DPX-F5384 ESTOL 1550 ETHYL PHTHALATE NCI-C60048 NEANTINE PALATINOL A or PHTHALOL PHTHALSAEUREDIAETHYLESTER PLACIDOL E RCRA WASTE NUMBER U088

D70


F70


H70

SRC determined from a measured vapor pressure of 2.1X10-3 mm Hg at 25 deg C [Hinckley DA et al; J Chem Eng Data 35: 232-37 (1990)] and water solubility of 1X10+3 mg/l at 25 deg C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)] **PEER REVIEWED**

M70


O70


A71

2,4-dimethylphenol Synonyms: Phenol, 2,4-dimethyl- Caswell No. 907A EPA Pesticide Chemical Code 086804 HSDB 4253 m-XYLENOL NSC 3829 RCRA WASTE NUMBER U101 1-HYDROXY-2,4-DIMETHYLBENZENE 2,4-Xylenol 4-HYDROXY-1,3-DIMETHYLBENZENE 4,6-DIMETHYLPHENOL

D71


F71

RIDDICK,J.A.; BUNGER,W.B.; SAKANO,T.K.; ORGANIC SOLVENTS: PHYSICAL PROPERTIES AND METHODS OF PURIFICATION.; TECHNIQUES OF CHEMISTRY. 4TH ED. NEW YORK,NY: WILEY-INTERSCIENCE. 2:PP.1325; 1986

H71

@ 25 degrees C ABRAHAM,MH ET AL. (1994)

M71


O71


A72

Di-n-Butyl Phthalate Synonyms: 1,2-Benzenedicarboxylic Acid Dibutyl Ester o-Benzenedicarboxylic Acid, Dibutyl Ester Benzene-o-Dicarboxylic Acid Di-n-Butyl Ester Butylphthalate Celluflex DPB Dibutyl 1,2-Benzene dicarboxylate Dibutyl phthalate Di-n-Butylphthalate Dibutyl-o-Phthalate DPB Elaol Ergoplast FDB Genoplast B Hexaplast M/B N-Butylphthalate Palatinol C Phthalic Acid Dibutyl Ester Polycizer DBP PX 104 RC Plasticizer DBP

D72


F72


H72

[Roy WR; pp. 411-46 in Contam Groundwaters. Adrianao DC et al eds. Northwood,UK: Sci Rev (1994)]**PEER REVIEWED**

M72


O72

+/- 0.003 @ 20 degrees C [Howard PH et al; Environ Tox and Chem 4: 653-61 (1985)]**PEER REVIEWED**

A73

Dinitrobenzene, meta Synonyms: benzene, 1,3-dinitrobenzene, m-dinitro- binitrobenzene 1,3-dinitrobenzene 2,4-dinitrobenzene Dinitrobenzene, m- 1,3-dinitrobenzol dwunitrobenzen UN 1597

D73


H73


K73

SRC determined from a measured log Kow of 1.49 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 17 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M73


O73

@ 25 degrees C YALKOWSKY,S.H.; ARIZONA DATABASE OF AQUEOUS SOLUBILITY; COLLEGE OF PHARMACY, UNIVERSITY OF ARIZONA. TUCSON, AZ.; 1989

A74

Dinitrobenzene, ortho Synonyms: Benzene, 1,2-dinitro- AI3-15338 Benzene, o-dinitro- HSDB 4486 o-dinitrobenzene 1,2-Dinitrobenzene

D74

[Lide, DR (ed.). CRC Handbook of Chemistry and Physics. 81st Edition. CRC Press LLC, Boca Raton: FL 2000, p. 343]**PEER REVIEWED**

H74

SRC calculated from a vapor pressure of 4.5X10-5 mm Hg [Yaws CL; Handbook of Vapor Pressure. Vol 2 C5-C7 Compounds. Houston, TX: Gulf Publ Co p. 391 (1994)] and water solubility of 133 mg/l [SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)] **PEER REVIEWED**

K74

SRC determined from a measured log Kow of 1.69 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 17 (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M74


O74


A75

2,4-DNT Synonyms: BENZENE, 1-METHYL-2,4-DINITRO- 2,4-DINITROTOLUOL 2,4-DNT 1-METHYL-2,4-DINITROBENZENE TOLUENE, 2,4-DINITRO-

D75


F75


H75

@ 25 degrees C ALTSCHUH,J ET AL. (1999)

K75


M75


O75

@ 22 degrees C [Spanggord RJ et al; Environmental fate studies on certain munition wastewater constituents Phase I-Literature Review p.30 (1980)] **PEER REVIEWED**

A76

IRIS only has tox profile on a 2,4-/2,6-Dinitrotoluene mixture.

D76


F76


H76


K76

Average of range from 19 to 72 Kenaga EE; Ecotocx Environ Safety 4: 26-38 (1980) **PEER REVIEWED**

M76

NAKAGAWA,Y ET AL. (1992)

O76

@ 20 degrees C SPANGGORD,RJ ET AL. (1980)

A77

Endrin Synonyms: mendrin, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4(a)5,6,7,8,8a-octahydro-endo

D77


F77

[Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 445]**PEER REVIEWED**

H77


M77

[Debruijn J, Hermens J; Environ Toxicol Chem 10:791-804 (1991)]**PEER REVIEWED**

O77

@ 25 degrees C [Biggar JW, Riggs RI; Higardia 42: 383-91 (1974)]**PEER REVIEWED**

A78

Ethylene glycol Synonyms: ATHYLENGLYKOL 1,2-DIHYDROXYETHANE DOWTHERM SR 1 1,2-ETHANDIOL 1,2-ETHANEDIOL ETHYLENE ALCOHOL ETHYLENE DIHYDRATE GLYCOL GLYCOL ALCOHOL LUTROL-9 M.E.G. MACROGOL 400 BPC MONOETHYLENE GLYCOL NCI-C00920 NORKOOL TESCOL UCAR 17

D78


F78


H78

@ 25 degrees C HINE,J.; MOOKERJEE,P.K.; THE INTRINSIC HYDROPHILIC CHARACTER OF ORGANIC COMPOUNDS. CORRELATIONS IN TERMS OF STRUCTURAL CONTRIBUTIONS.; J. ORG. CHEM.; 40:292-8.; 1975

K78


M78


O78

RIDDICK,JA ET AL. (1986)

A79

FLUORANTHENE Synonyms: 1,2-BENZACENAPHTHENE BENZENE, 1,2-(1,8-NAPHTHALENEDIYL)- BENZENE, 1,2-(1,8-NAPHTHYLENE)- BENZO(JK)FLUORENE HSDB 5486 IDRYL 1,2-(1,8-NAPHTHYLENE)BENZENE NSC 6803 RCRA WASTE NUMBER U120

D79


F79

[Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 428]**PEER REVIEWED**

H79

@ 20 degrees C [Shiu WY, Mackay D; J Chem Eng Data 42: 27-30 (1997)] **PEER REVIEWED**

M79


O79

@ 24 deg C (99% purity) [Verschueren, K. Handbook of Environmental Data on Organic Chemicals. 3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996., p. 1007]**PEER REVIEWED**

A80

Fluorene Synonyms: 9H-Fluorene Diphenylenemethane HSDB 2165 Methane, diphenylene- NSC 6787 o-BIPHENYLENEMETHANE 2,2'-METHYLENEBIPHENYL

D80


H80


M80


O80

MAY,WE & WASIK,SP (1978)

A81

Heptachlor Synonyms: AGROCERES 3-CHLOROCHLORDENE DICYCLOPENTADIENE, 3,4,5,6,7,8,8a-HEPTACHLORO- DRINOX or DRINOX H-34 E 3314 or ENT 15,152 EPTACLORO 1,4,5,6,7,8,8-EPTACLORO-3a,4,7,7a-TETRAIDRO-4,7-endo-METANO- INDENE GPKh H H-34 HEPTACHLOOR 1,4,5,6,7,8,8-HEPTACHLOOR-3a,4,7,7a-TETRAHYDRO-4,7-endo- METHANO-INDEEN Heptachlor HEPTACHLORE 1(3a),4,5,6,7,8,8-HEPTACHLORO-3a(1),4,7,7a-TETRAHYDRO-4,7- METHANOINDENE 3,4,5,6,7,8,8-HEPTACHLORODICYCLOPENTADIENE 3,4,5,6,7,8,8a-HEPTACHLORODICYCLOPENTADIENE 1,4,5,6,7,8,8-HEPTACHLORO-3a,4,7,7a-TETRAHYDRO-4,7- ENDOMETHANOINDENE 1,4,5,6,7,10,10-HEPTACHLORO-4,7,8,9-TETRAHYDRO-4,7- ENDOMETHYLENEINDENE 1,4,5,6,7,8,8a-HEPTACHLORO-3a,4,7,7a-TETRAHYDRO-4,7- METHANOINDANE 1,4,5,6,7,8,8-HEPTACHLORO-3a,4,7,7a-TETRAHYDRO-4,7- METHANOINDENE 1,4,5,6,7,8,8-HEPTACHLORO-3a,4,7,7a-TETRAHYDRO-4,7- METHANOL-1H-INDENE 1,4,5,6,7,10,10-HEPTACHLORO-4,7,8,9-TETRAHYDRO-4,7- METHYLENEINDENE 1,4,5,6,7,8,8-HEPTACHLORO-3a,4,7,7,7a-TETRAHYDRO-4,7- METHYLENE INDENE 1,4,5,6,7,8,8-HEPTACHLOR-3a,4,7,7,7a-TETRAHYDRO-4,7-endo- METHANO-INDEN HEPTAGRAN or HEPTAMUL 4,7-METHANOINDENE, 1,4,5,6,7,8,8-HEPTACHLORO-3a,4,7,7a- TETRAHYDRO- NA 2761 or NCI-C00180 RCRA WASTE NUMBER P059 RHODIACHLOR or VELSICOL 104

D81


H81

@ 25 degrees C [Altschuh J et al; Chemosphere 39: 1871-87 (1999)] **PEER REVIEWED**

M81

SIMPSON,CD ET AL. (1995)

O81

@ 25 degrees C [Biggar JW, Riggs RI; Hilgardia 42: 383-91 (1974)]**PEER REVIEWED**

A82

Heptachlor Epoxide Synonyms: ENT 25,584 EPOXYHEPTACHLOR or HCE 1,4,5,6,7,8,8-HEPTACHLORO-2,3-EPOXY-2,3,3a,4,7,7a-HEXAHYDRO -4,7-METHANOINDENE 1,4,5,6,7,8,8-HEPTACHLORO-2,3-EPOXY-3a,4,7,7a-TETRAHYDRO -4,7-METHANOINDAN 2,3,4,5,6,7,7-HEPTACHLORO-1a,1b,5,5a,6,6a-HEXAHYDRO-2,5-METHANO -2H-INDENO(1,2- b)OXIRENE HIPTACHLOR EPOXIDE 4,7-METHANOINDAN, 1,4,5,6,7,8,8-HEPTACHLORO-2,3-EPOXY-3a,4, 7,7a-TETRAHYDRO- 2,5-METHANO-2H-OXIRENO(a)INDENE, 2,3,4,5,6,7,7-HEPTACHLORO- 1a,1b,5,5a,6,6a- HEXAHYDRO- VELSICOL 53-CS-17

D82


H82


M82

SANGSTER (1993)

O82

[Hayes, Wayland J., Jr. Pesticides Studied in Man. Baltimore/London: Williams and Wilkins, 1982., p. 233]**PEER REVIEWED**

Hexachloro- 1,3 - Butadiene 87-68-3 NV 260.76 b -21.00 b 1.03E-02 b 4.21E-01 5.37E+04 e 4.78E+00 c 3.20E+00 b 5.61E-02 h 6.16E-06 h 1 0.1 8.10E-02 1Hexachlorobenzene 118-74-1 NV 284.78 b 231.80 b 5.80E-04 b 2.37E-02 8.00E+04 e 5.73E+00 b 4.70E-03 b 5.42E-02 h 5.91E-06 h 1 0.1 1.30E-01 1Hexachloroethane 67-72-1 NV 236.74 b 185.00 b 3.89E-03 b 1.59E-01 1.78E+03 e 4.14E+00 c 7.70E+00 b 2.50E-03 h 6.80E-06 h 1 0.1 3.00E-02 1Indeno(1,2,3-c,d)pyrene 193-39-5 NV 276.34 b 163.60 b 3.48E-07 b 1.42E-05 3.47E+06 e 6.70E+00 c 2.20E-05 a 2.25E-02 h 5.66E-06 h 1 0.13 1.00E+00 1Isophorone 78-59-1 NV 138.21 b -8.10 b 6.60E-06 b 2.70E-04 4.68E+01 e 1.70E+00 c 1.20E+04 b 6.23E-02 h 6.76E-06 h 1 0.1 3.40E-03 1Isopropylbenzene (Cumene) 98-82-8 NV 120.19 b -96.00 b 1.15E-02 b 4.70E-01 8.20E+02 b 3.66E+00 c 5.00E+01 b 6.50E-02 h 7.10E-06 h 1 0.1 4.10E-01 1Lindane 58-89-9 NV 290.83 b 112.50 b 5.14E-06 c 2.10E-04 1.35E+03 e 3.72E+00 c 7.30E+00 b 2.75E-02 h 7.34E-06 h 1 0.04 1.10E-02 1m-cresol 108-39-4 NV 108.14 b 12.22 a 8.56E-07 c 3.50E-05 4.34E+02 d 1.96E+00 c 2.27E+04 b 7.40E-02 h 1.00E-05 h 1 0.1 7.80E-03 1Methoxychlor 72-43-5 NV 345.65 b 87.00 b 2.03E-07 b 8.30E-06 8.00E+04 e 5.08E+00 c 4.00E-02 b 1.84E-02 h 4.46E-06 h 1 0.1 3.60E+00 1Methylnaphthalene, 1 - 90-12-0 NV 142.19 b -22.00 b 5.14E-04 b 2.10E-02 2.30E+03 b 3.87E+00 c 2.58E+01 b 5.27E-02 h 7.84E-06 h 1 0.13 2.55E+00 1Naphthalene 91-20-3 NV 128.17 b 80.20 b 4.40E-04 b 1.80E-02 1.19E+03 e 3.30E+00 c 3.10E+01 b 5.90E-02 h 7.50E-06 h 1 0.13 4.70E-02 1Nitrobenzene 98-95-3 NV 123.11 b 5.70 b 2.40E-05 b 9.82E-04 1.19E+02 e 1.85E+00 c 1.80E+03 b 7.60E-02 h 8.60E-06 h 1 0.1 2.60E-02 1

86-30-6 NV 198.23 b 66.50 b 1.21E-06 b 4.95E-05 1.29E+03 e 3.13E+00 c 3.51E+01 b 2.83E-02 h 7.19E-06 h 1 0.1 1.50E-02 1o-cresol 95-48-7 NV 108.14 b 30.00 b 1.20E-06 b 4.91E-05 4.43E+02 d 1.95E+00 c 2.59E+04 b 7.40E-02 h 8.30E-06 h 1 0.1 7.70E-03 1

117-84-0 NV 390.56 b -25.00 b 4.50E-07 b 1.84E-05 1.00E+05 b 8.10E+00 c 2.00E-02 a 1.73E-02 h 4.17E-06 h 1 0.1 3.52E+02 1p-cresol 106-44-5 NV 108.14 b 35.50 b 1.00E-06 b 4.09E-05 4.34E+02 d 1.94E+00 c 2.50E+04 b 7.40E-02 h 1.00E-05 h 1 0.1 7.70E-03 1Pentachlorophenol 87-86-5 NV 266.34 b 174.00 b 2.45E-08 b 1.00E-06 5.92E+02 g 5.12E+00 c 1.40E+01 b 5.60E-02 h 6.10E-06 h 1 0.25 3.90E-01 0.9Phenol 108-95-2 NV 94.11 b 40.91 b 3.33E-07 b 1.36E-05 2.88E+01 e 1.46E+00 c 8.28E+04 b 8.20E-02 h 9.10E-06 h 1 0.1 4.30E-03 1Polychlorinated Biphenyls 1336-36-3 NV 291.99 c 122.32 d 4.15E-04 c 1.70E-02 3.09E+05 d 7.10E+00 c 7.00E-01 c 2.22E-02 h 8.00E-06 h 1 0.14 7.70E+01 0.5Pyrene 129-00-0 NV 202.26 b 151.20 b 1.20E-05 b 4.91E-04 6.80E+04 e 4.88E+00 c 1.35E-01 b 2.77E-02 h 7.24E-06 h 1 0.13 2.64E+00 1Pyridine 110-86-1 NV 79.10 b -41.60 b 1.10E-05 b 4.50E-04 5.00E+01 b 6.50E-01 c 1.00E+06 c 9.10E-02 h 7.60E-06 h 1 0.1 4.00E-03 1Silvex (2,4,5-T) 93-72-1 NV 261.51 b 181.60 b 9.06E-09 c 3.71E-07 8.04E+01 d 3.80E+00 c 1.40E+02 2.30E-02 h 5.83E-06 h 1 0.1 5.10E-01 1Toxaphene 8001-35-2 NV 414.00 b 77.00 c 6.00E-06 b 2.45E-04 9.58E+04 e 5.90E+00 c 5.50E-01 b 2.16E-02 h 5.51E-06 h 1 0.1 1.20E-02 0.8Trichlorophenol, 2,4,5 - 95-95-4 NV 197.45 b 69.00 b 1.60E-06 b 6.54E-05 1.60E+03 g 3.72E+00 c 1.20E+03 b 2.91E-02 h 7.03E-06 h 1 0.1 4.50E-01 1Trichlorophenol, 2,4,6 - 88-06-2 NV 197.45 b 69.00 b 2.60E-06 b 1.06E-04 3.81E+02 g 3.69E+00 c 8.00E+02 b 2.61E-02 h 6.36E-06 h 1 0.1 3.50E-02 1Trimethylbenzene, 1,2,4 95-63-6 NV 120.20 b -43.80 b 6.16E-03 b 2.52E-01 7.20E+02 b 3.78E+00 b 5.70E+01 b 6.06E-02 h 7.92E-06 h 1 0.1 5.00E-01 1Trimethylbenzene, 1,3,5 108-67-8 NV 120.19 b -44.80 b 8.77E-03 b 3.59E-01 6.60E+02 b 3.42E+00 c 4.82E+01 b 6.02E-02 h 8.67E-06 h 1 0.1 3.00E-01 1Trinitrobenzene, 1,3,5 - (s) 99-35-4 NV 213.11 b 122.50 b 3.31E-10 c 1.35E-08 1.09E+03 d 1.18E+00 c 2.78E+02 c 2.44E-02 h 6.15E-07 h 1 0.1 1.00E-02 1Vinyl Acetate 108-05-4 NV 86.09 b -93.20 b 5.10E-04 b 2.09E-02 5.25E+00 e 7.30E-01 c 2.00E+04 b 8.50E-02 h 9.20E-06 h 1 0.1 5.00E-03 1

Inorganic AnalytesAntimony 7440-36-0 NV 121.75 b 630.00 b NA - na NA - 7.30E-01 c 2.30E+04 c 7.72E-02 h 9.57E-06 h 0.15 NA 1.00E-03 NAArsenic, Inorganic 7440-38-2 NV 74.92 b 817.00 d NA - na NA - 6.80E-01 c 3.47E+04 c 7.72E-02 h 9.57E-06 h 1 0.03 1.00E-03 NABarium and Compounds 7440-39-3 NV 137.327 b 727.00 b NA - na NA - 2.30E-01 c 5.48E+04 c 7.72E-02 h 9.57E-06 h 0.07 NA 1.00E-03 NABeryllium and Compounds 7440-41-7 NV 9.012 b 1287.00 b NA - na NA - -5.70E-01 c 1.49E+05 c 7.72E-02 h 9.57E-06 h 0.007 NA 1.00E-03 NACadmium 7440-43-9 NV 112.41 b 321.00 b NA - na NA - -7.00E-02 c 1.23E+05 c 7.72E-02 h 9.57E-06 h 0.05 0.001 1.00E-03 NAChromium (III) 16065-83-1 NV 52.00 f 1900.00 f NA - na NA - NA - 0.00E+00 d NA - NA - 0.013 NA 1.00E-03 NAChromium (VI) 18540-29-9 NV 52.00 f 1900.00 f NA - na NA - NA - 1.69E+06 d NA - NA - 0.025 NA 2.00E-03 NAChromium (Total) NA NV NA - NA - NA - na NA - NA - NA - NA - NA - NA NA NA NACobalt 7440-48-4 NV 58.93 b 1495.00 b NA - na NA - 2.30E-01 f 0.00E+00 d 7.72E-02 h 9.57E-06 h 1 NA 4.00E-04 NACyanide, Free 57-12-5 NV 26.02 c NA - NA - na NA - -6.90E-01 c 9.54E+04 c 1.56E-01 h 1.77E-05 h 1 NA 1.00E-03 NAFluorine (soluble fluoride) 7782-41-4 NV 37.997 b -219.61 b NA - na NA - 2.20E-01 c 1.69E+00 b 1.56E-01 h 1.71E-05 h 1 NA 1.00E-03 NAMercury 7439-97-6 NV 200.59 b -38.87 b NA - na NA - 6.20E-01 c 6.00E-02 c 7.14E-02 h 3.01E-05 h 1 NA 1.00E-03 NANickel (Soluble Salts) Various NV NA - NA - NA - na NA - NA - NA - NA - NA - 0.04 NA 2.00E-04 NASelenium and Compounds 7782-49-2 NV 78.96 b 221.00 b NA - na NA - 2.40E-01 c 2.06E+03 c 7.72E-02 h 9.57E-06 h 1 NA 1.00E-03 NASilver 7440-22-4 NV 107.86 b 960.50 b NA - na NA - 2.30E-01 c 7.05E+04 c 7.72E-02 h 9.57E-06 h 0.04 NA 6.00E-04 NAThallium 7440-28-0 NV 204.38 b 304.00 b NA - na NA - 2.30E-01 c 2.65E+04 c 7.72E-02 h 9.57E-06 h 1 NA 1.00E-03 NAVanadium 7440-62-2 NV 50.9415 b 1910.00 b NA - na NA - NA - 0.00E+00 d 7.72E-02 h 9.57E-06 h 0.026 NA 1.00E-03 NAZinc and Compounds 7440-66-6 NV 65.38 b 419.50 b NA - na NA - -4.70E-01 c 3.44E+05 c 7.72E-02 h 9.57E-06 h 1 NA 6.00E-04 NA

Supplemental Criteria2-methylnaphthalene 91-57-6 NV 142.2 b 34.60 a 5.18E-04 b 2.12E-02 6.45E+03 b 3.86E+00 c 2.46E+01 b 5.22E-02 h 7.75E-06 h 1 0.13 5.60E-01 14-chlorotoluene 106-43-4 NV 126.59 b 7.50 b 4.40E-03 b 1.80E-01 3.40E+02 b 3.33E+00 c 1.06E+02 b 6.25E-02 h 8.65E-06 h 1 0.1 2.50E-01 1Acenaphthylene 208-96-8 NV 152.2 b 92.50 c 1.13E-04 a 4.62E-03 2.65E+03 b 3.94E+00 c 1.61E+01 c 4.49E-02 h 6.98E-06 h 1 0.13 6.30E-01 1Benzo(g,h,i)perylene 191-24-2 NV 276.34 b 277.00 b 2.66E-07 b 1.09E-05 9.60E+04 b 6.63E+00 c 2.60E-04 c 2.17E-02 h 5.26E-06 h 1 0.13 3.80E+01 1Copper 7440-50-8 NV 63.546 b 1083.00 b NA - na NA - -5.70E-01 c 4.21E+05 c 7.72E-02 h 9.57E-06 h 1 NA 1.00E-03 NADimethyl phthalate 131-11-3 NV 194.19 b 5.50 b 2.00E-07 b 8.18E-06 2.20E+02 b 1.60E+00 c 4.00E+03 c 5.68E-02 h 6.29E-06 h 1 0.1 1.40E-03 1Methyl butyl ketone 591-78-6 NV 100.16 b -55.50 b 9.32E-05 b 3.81E-03 1.34E+02 b 1.38E+00 c 1.72E+04 b NA - NA - 1 0.1 1.30E-02 1n-butyl benzene 104-51-8 NV 134.22 b -87.90 b 1.60E-02 b 6.54E-01 2.48E+03 b 4.38E+00 c 1.18E+01 c 5.70E-02 h 8.12E-06 h 1 0.1 1.23E+00 1n-propyl benzene 103-65-1 NV 120.19 b -99.50 b 1.05E-02 b 4.29E-01 7.25E+02 b 3.69E+00 c 5.22E+01 c 6.01E-02 h 7.83E-06 h 1 0.1 4.30E-01 1Phenanthrene 85-01-8 NV 178.22 b 101.00 b 4.23E-05 c 1.73E-03 2.29E+04 b 4.46E+00 c 1.28E+00 b 3.75E-02 h 7.47E-06 h 1 0.13 1.40E-01 1p-isopropyltoluene (Cymene) 99-87-6 NV 134.22 b -68.90 b 1.10E-02 b 4.50E-01 4.05E+03 b 4.10E+00 c 2.34E+01 c 5.60E-02 h 7.33E-06 h 1 0.1 8.10E-01 1Sec-butyl benzene 135-98-8 NV 134.22 b -82.70 b 1.80E-02 b 7.36E-01 7.20E+03 b 4.57E+00 c 1.76E+01 b 5.70E-02 h 8.12E-06 h 1 0.1 1.65E+00 1Tert-butyl benzene 98-06-6 NV 134.22 b -57.80 b 1.32E-02 b 5.40E-01 1.18E+03 b 4.11E+00 c 2.95E+01 c 5.65E-02 h 8.02E-06 h 1 0.1 8.20E-01 1

Nitrosodiphenylamine, n -

Octyl Phthalate, di(n) -

A83

1,3-Butadiene, Hexachloro- Synonyms: DOLEN-PUR GP-40-66:120 HCBD Hexachlor-1,3-Butadien HeXachlorbutadiene Hexachlorobutadiene 1,1,2,3,4,4-Hexachloro-1,3-Butadiene 1,3- Hexachlorobutadiene Perchlorobutadiene RCRA Waste Number U128 UN 2279

D83


F83

[Lide, DR (ed.). CRC Handbook of Chemistry and Physics. 81st Edition. CRC Press LLC, Boca Raton: FL 2000, p. 3-88] **PEER REVIEWED**

H83

@ 20 degrees C [Warner HP et al; Determination of Henry's Law Constants of Selected Priority Pollutants. USEPA/600/d-87/229. NTIS PB87-212684 (1987)]**PEER REVIEWED**

M83


O83

@ 25 degrees C [Banerjee S; Environ Sci Technol 18: 587-91 (1984)]**PEER REVIEWED**

A84

Hexachlorobenzene Synonyms: granox pentachlorophenyl chloride perchlorobenzene

D84


F84


H84

@ 25 degrees C [ten Hulscher TEM et al; Environ Toxicol Chem 11: 1595-1603 (1992)]**PEER REVIEWED**

M84

[Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 15] **PEER REVIEWED**

O84

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)] **PEER REVIEWED**

A85

Hexachloroethane Synonyms: AVLOTHANE CARBON HEXACHLORIDE DISTOKAL DISTOPAN or DISTOPIN EGITOL ETHANE HEXACHLORIDE ETHANE, HEXACHLORO- ETHYLENE HEXACHLORIDE FALKITOL or FASCIOLIN HEXACHLOR-AETHAN Hexachloroethane 1,1,1,2,2,2-HEXACHLOROETHANE HEXACHLOROETHYLENE MOTTENHEXE NA 9037 or NCI-C04604 PERCHLOROETHANE PHENOHEP RCRA WASTE NUMBER U131

D85


F85

[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present., p. VA6 282]**PEER REVIEWED**

H85

Munz C, Roberts PV; Res Technol 79: 62-9 (1987) **PEER REVIEWED**

M85


O85

@ 20 degrees C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona-Tucson, AZ. PC Version. (1992)] **PEER REVIEWED**

A86

Indeno(1,2,3-cd)pyrene Synonyms: HSDB 5101 o-PHENYLENEPYRENE RCRA WASTE NUMBER U137 1,10-(O-PHENYLENE)PYRENE 1,10-(1,2-Phenylene)pyrene 2,3-o-PHENYLENEPYRENE 2,3-PHENYLENEPYRENE

D86

[Verschueren, K. Handbook of Environmental Data on Organic Chemicals. 3rd ed. New York, NY: Van Nostrand Reinhold Co., 1996., p. 1140]**PEER REVIEWED**

F86

[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V32 374 (1983)] **PEER REVIEWED**

H86


M86


O86

@ 20 degrees C SIMS,R.C.; OVERCASH,M.R.; FATE OF POLYNUCLEAR AROMATIC COMPOUNDS (PNAS) IN SOIL-PLANT SYSTEMS.; RESIDUE REVIEWS.; 88:1-68.; 1983

A87

Isophorone Synonyms: Isoacetophorone Isoforon or Isophoron alpha-Isophoron Isophorone alpha-Isophorone 3,5,5-Trimethyl-2-cyclohexenone

D87


F87


H87

SRC derived from its vapor pressure, 0.438 mm Hg [Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, DC: Taylor and Francis (1989)] and water solubility, 12,000 mg/l [Parrish CF; Kirk-Othmer Encycl Chem Tech 3rd. NY, NY: Wiley-Intrsci 21: 377-401 (1983)] **PEER REVIEWED**

M87

VEITH,GD ET AL. (1980)

O87

@ 25 degrees C [Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V21(1983) 385] **PEER REVIEWED**

A88

Cumene Synonyms: isopropyl benzene isopropylbenzol 2-phenylpropane

D88


F88


H88

@ 25 degrees C [Sanemasa I et al; Bull Chem Soc Japan 55: 1054-62 (1982)] **PEER REVIEWED**

K88


M88


O88


A89

Lindane Synonyms: AALINDAN orAFICIDE AGRISOL G-20 AGRONEXIT AMEISENATOD AMEISENMITTEL MERCK APARASIN or APHTIRIA APLIDAL or ARBITEX BBH or BEN-HEX BENTOX 10 gamma-BENZENE HEXACHLORIDE BENZENE HEXACHLORIDE-gamma-isomer BEXOL BHC or gamma-BHC CELANEX CHLORESENE CODECHINE CYCLOHEXANE, 1,2,3,4,5,6-HEXACHLORO-, gamma-isomer DBH DETMOL-EXTRAKT DETOX 25 DEVORAN DOL GRANULE DRILL TOX-SPEZIAL AGLUKON ENT 7,796 or ENTOMOXAN EXAGAMA FORLIN GALLOGAMA GAMACARBATOX or GAMACID GAMAPHEX or GAMENE GAMISO or GAMMA-COL GAMMAHEXA or GAMMAHEXANE GAMMALIN or GAMMALIN 20 GAMMATERR or GAMMEX GAMMEXANE or GAMMOPAZ GEXANE HCCH or HCH gamma-HCH HECLOTOX HEXA or HEXACHLORAN or HEXACHLORANE gamma-HEXACHLORANE or gamma-HEXACHLORAN gamma-HEXACHLOR or gamma-HEXACHLOROBENZENE 1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE 1-alpha,2-alpha,3-beta,4-alpha,5-alpha,6-beta-HEXACHLOROCYCLOHEXANE Hexachlorocyclohexane, gamma- gamma-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE 1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE, gamma-ISOMER HEXACHLOROCYCLOHEXANE, gamma-ISOMER HEXATOX or HEXAVERM HEXICIDE or HEXYCLAN HGI or HORTEX INEXIT or ISOTOX JACUTIN or KOKOTINE KWELL LENDINE or LENTOX LIDENAL or LINDAFOR LINDAGAM or LINDAGRAIN LINDAGRANOX gamma-LINDANE LINDAPOUDRE or LINDATOX LINDOSEP or LINTOX LOREXANE MILBOL 49 or MSZYCOL NA 2761 or NCI-C00204 NEO-SCABICIDOL NEXEN FB NEXIT or NEXIT-STARK or NEXOL-E NICOCHLORAN or NOVIGAM OMNITOX or OWADZIAK PEDRACZAK or PFLANZOL QUELLADA RCRA WASTE NUMBER U129 SANG gamma SILVANOL SPRITZ-RAPIDIN SPRUEHPFLANZOL STREUNEX TAP 85 or TRI-6 VITON

D89


F89


H89


M89


O89

@ 25 degrees C [Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 665]**PEER REVIEWED**

A90

m-cresol Synonyms: Phenol, 3-methyl- Caswell No. 261A EPA Pesticide Chemical Code 022102 HSDB 1815 m-CRESYLIC ACID m-HYDROXYTOLUENE m-KRESOL m-METHYLPHENOL m-OXYTOLUENE m-TOLUOL meta-cresol NSC 8768 1-HYDROXY-3-METHYLBENZENE 3-cresol 3-HYDROXYTOLUENE 3-Methylphenol

D90


F90

RIDDICK,J.A.; BUNGER,W.B.; SAKANO,T.K.; ORGANIC SOLVENTS: PHYSICAL PROPERTIES AND METHODS OF PURIFICATION.; TECHNIQUES OF CHEMISTRY. 4TH ED. NEW YORK,NY: WILEY-INTERSCIENCE. 2:PP.1325; 1986

H90

ALTSCHUH,J ET AL. (1999)

K90


M90


O90

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)] **PEER REVIEWED**

A91

Methoxychlor Synonyms: 72-43-5 2,2-di-p-anisyl-1,1,1-trichloroethane DMDT marlate or methorcide methoxy-DDT moxie 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)ethane

D91


F91


H91


M91


O91


D92

[Verschueren, K. Handbook of Environmental Data on Organic Chemicals. Volumes 1-2. 4th ed. John Wiley & Sons. New York, NY. 2001, p. V2 1513]**PEER REVIEWED**

F92

[Verschueren, K. Handbook of Environmental Data on Organic Chemicals. Volumes 1-2. 4th ed. John Wiley & Sons. New York, NY. 2001, p. V2 1513]**PEER REVIEWED**

H92

@ 25 degrees C [Altschuh J et al; Chemosphere 39: 1871-87 (1999) ]**PEER REVIEWED**

K92

Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992) **PEER REVIEWED**

M92


O92

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The Aquasol Database of Aqueous Solubility. Ver 5. Tucson, AZ: Univ AZ, College of Pharmacy (1992) ]**PEER REVIEWED**

A93

Naphthalene Synonyms: Albocarbon Caswell No. 587 Dezodorator EPA Pesticide Chemical Code 055801 HSDB 184 MOTH BALLS MOTH FLAKES Naftalen [Polish] Naftaleno [Spanish] Naphtalene [French] Naphthalin or Naphthaline Naphthene NAPTHALENE, molten NCI-C52904 or NSC 37565 RCRA WASTE NUMBER U165 TAR CAMPHOR UN 1334 or UN 2304 WHITE TAR

D93


F93


H93

@ 25 degrees C [Shiu WY, Mackay D; J Chem Eng Data 42: 951-53 (1997) ]**PEER REVIEWED**

M93


O93

@ 25 degrees C [Pearlman RS et al; J Chem Ref Data 13:555-562 (1984) ] **PEER REVIEWED**

A94

Nitrobenzene Synonyms: Essence of Mirbane Essence of Myrbane Mirbane Oil NCI-C60082 Nitrobenzol Oil of Mirbane Oil of Myrbane

D94


F94


H94

Kopinke FD et al; Environ Sci Technol 29: 941-50 (1995) **PEER REVIEWED**

M94


O94

[Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ. PC Version (1992)]**PEER REVIEWED**

A95

Nitrosodiphenylamine, N- Synonyms: BENZENAMINE, N-NITROSO-N-PHENYL- CURETARD A DELAC J DIPHENYLAMINE, N-NITROSO- DIPHENYLNITROSAMIN DIPHENYLNITROSAMINE DIPHENYL N-NITROSOAMINE NAUGARD TJB NCI-C02880 NDPA or NDPhA NITROSODIPHENYLAMINE NITROUS DIPHENYLAMIDE N,N-DIPHENYLNITROSAMINE N-NITROSODIFENYLAMIN N-Nitrosodiphenylamine N-NITROSO-N-PHENYLANILINE REDAX or RETARDER J TJB VULCALENT A or VULCATARD VULCATARD A or VULKALENT A VULTROL

D95


F95


H95


M95


O95


A96

o-cresol Synonyms: Phenol, 2-methyl- Cresols (o-,m-,p-) HSDB 1813 NSC 23076 NSC 36809 o-Cresylic acid o-HYDROXYTOLUENE o-KRESOL [German] o-METHYLPHENOL o-METHYLPHENYLOL o-OXYTOLUENE o-TOLUOL Orthocresol 1-HYDROXY-2-METHYLBENZENE 2-cresol 2-HYDROXYTOLUENE 2-Methylphenol

D96


F96


H96


M96


O96


D97

[Weast, R.C. and M.J. Astle. CRC Handbook of Data on Organic Compounds. Volumes I and II. Boca Raton, FL: CRC Press Inc. 1985., p. V2 113]**PEER REVIEWED**

F97

[Callahan, M.A., M.W. Slimak, N.W. Gabel, et al. Water-Related Environmental Fate of 129 Priority Pollutants. Volume II. EPA-440/4-79-029b. Washington, D.C.: U.S. Environmental Protection Agency, December 1979., p. 94-5]**PEER REVIEWED**

H97

SRC estimated from its experimental values for vapor pressure, 2.6X10-6 mm Hg [Perwak J et al; Exposure and Risk Assessment for Phthalate Esters. Cambridge, MA: Arthur D. Little Inc USEPA-440/4-81-020 (NTIS PB85-211936) (1981)] and water solubility, 3 mg/l [Wolfe NL et al; Chemosphere 9: 403-8 (1980) (6) Mathur SP; J Environ Qual 3: 189-97 (1974)] **PEER REVIEWED**

K97

Mean Koc [Ritsema R et al; Chemosphere 18: 2161-75 (1989)] SRC determined an estimated Koc value of 6.1X10+5 from a measured log Kow of 8.1 [Ellington JJ, Floyd TL; Octanol/water partition coefficients for eight phthalate esters. Athens, GA: USEPA National Exposure Research Lab. USEPA/600/S-96/006 (1996)] and a recommended regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington,DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M97


O97

@ 25 degrees C DEFOE,D.L.; HOLCOMBE,G.W.; HAMMERMEISTER,D.E.; SOLUBILITY AND TOXICITY OF EIGHT PHTHALATE ESTERS TO FOUR AQUATIC ORGANISMS.; ENVIRON. TOXICOL. CHEM.; 9:623-36; 1990

A98

p-cresol Synonyms: Phenol, 4-methyl- Cresols (o-,m-,p-) HSDB 1814 NSC 3696 p-Cresol p-CRESYLIC ACID p-HYDROXYTOLUENE p-KRESOL p-METHYLHYDROXYBENZENE p-METHYLPHENOL p-OXYTOLUENE p-TOLUOL p-TOLYL ALCOHOL para-cresol PARAMETHYL PHENOL 1-HYDROXY-4-METHYLBENZENE 1-METHYL-4-HYDROXYBENZENE 4-cresol 4-HYDROXYTOLUENE 4-Methylphenol

D98


F98


H98


K98


M98


O98

@ 50 degrees C [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 437]**PEER REVIEWED**

A99

Pentachlorophenol Synonyms: Chem-Tol Chlorophen Cryptogil OL Dowcide 7 or Dowicide EC-7 DP-2, technical Durotox EP 30 Fungifen Glazd penta Grundier arbezol 1-Hydroxy- 2,3,4,5,6-pentachlorobenzene Lauxtol or Lauxtol A Liroprem NCI-C54933 or NCI-C55378 NCI-C55389 or NCI-C56655 PCP Penchlorol or Penta Pentachloorfenol Pentachlorofenol Pentachlorofenolo Pentachlorophenate Pentachlorophenol 2,3,4,5,6-Pentachlorophenol. Pentachlorphenol Pentaclorofenolo Pentacon or Penta-Kil Pentasol Penwar Peratox Permacide Permagard or Permasan Permatox or Permatox dp-2 Permatox penta Permite Phenol, pentachloro- Preventol P Priltox Santobrite Santophen or Santophen 20 Sinituho Term-i-trol WLN: QR BG CG DG EG FG

D99


F99


H99

[Hellman H; Fresenius' Z Anal Chem 328: 475-79 (1987)]**PEER REVIEWED**

M99


O99


A100

Phenol Synonyms: Benzenol Carbolic Acid Hydroxybenzene Izal Monohydroxybenzene Monophenol NCI-C50124 Oxybenzene Phenic Acid Phenyl Alcohol Phenyl Hydrate Phenyl Hydroxide Phenylic Acid Phenylic Alcohol

D100


F100


H100


M100


O100

@ 25 degrees C [Southworth GR, Keller JL; Water Air Soil Poll 28: 239-48 (1986)]**PEER REVIEWED**

A101

PCBs Synonyms: AROCLOR AROCLOR 1221 AROCLOR 1232 AROCLOR 1242 AROCLOR 1248 AROCLOR 1254 AROCLOR 1260 AROCLOR 1262 AROCLOR 1268 AROCLOR 2565 AROCLOR 4465 AROCLOR 5442 CHLOPHEN CHLOREXTOL CHLORINATED BIPHENYL CHLORINATED DIPHENYL CHLORINATED DIPHENYLENE CHLORO BIPHENYL CHLORO 1,1-BIPHENYL CLOPHEN DYKANOL FENCLOR INERTEEN KANECHLOR KANECHLOR 300 or KANECHLOR 400 MONTAR NOFLAMOL PHENOCHLOR or PHENOCLOR POLYCHLORINATED BIPHENYL POLYCHLOROBIPHENYL PYRALENE PYRANOL SANTOTHERM or SANTOTHERM FR SOVOL THERMINOL FR-1 UN 2315

F101


H101

@ 25 degrees C BURKHARD,LP ET AL. (1985A)

K101


M101

HANSCH,C ET AL. (1995) avg tetra-

O101

@ 25 degrees C GRIFFIN,RA & CHOU,SFJ (1981)

A102

Pyrene Synonyms: BENZO(DEF)PHENANTHRENE HSDB 4023 NSC 17534 PYRENE BETA-PYRENE

D102


F102


H102

Shiu WY, Mackay D; J Chem Eng Dat 42: 27-30 (1997) **PEER REVIEWED**

M102


O102

(+ or - 0.005 MG/L) @ 25 degrees C [MACKAY D, SHIU WY; J CHEM ENG DATA 22: 399-402 (1977)]**PEER REVIEWED**

A103

Pyridine Synonyms: AZABENZENE AZINE NCI-C55301 PIRIDINA or PIRYDYNA PYRIDIN RCRA WASTE NUMBER U196 TRITISAN

D103


F103


H103

@ 25 degrees C [Hawthorne SB et al; Environ Sci Technol 19: 922-7 (1985)]**PEER REVIEWED**

K103


M103


O103

@ 25 degrees C GOE,GL (1978)

A104

Silvex Synonyms: 2 (2,4,5-Trichlorophenoxy) Propionic Acid ACIDE 2-(2,4,5-TRICHLORO-PHENOXY) PROPIONIQUE ACIDO 2-(2,4,5-TRICLORO-FENOSSI)-PROPIONICO ALPHA-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID PROPANOIC ACID, 2-(2,4,5-TRICHLOROPHENOXY)- PROPIONIC ACID, 2-(2,4,5-TRICHLOROPHENOXY)- 2,4,5-TP 2-(2,4,5-TRICHLOOR-FENOXY)-PROPIONZUUR 2,4,5-TRICHLOROPHENOXY-ALPHA-PROPIONIC ACID (+/-)-2-(2,4,5-trichlorophenoxy)propanoic acid 2-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID 2,4,5-TRICHLOROPHENOXYPROPIONIC ACID Trichlorophenoxy Propionic Acid, 2 (2,4,5- 2-(2,4,5-TRICHLOR-PHENOXY)-PROPIONSAEURE Fenoprop

D104

[U.S. Department of Health and Human Services, Public Health Service, Center for Disease Control, National Institute for Occupational Safety Health. Registry of Toxic Effects of Chemical Substances (RTECS). National Library of Medicine's current MEDLARS file., p. 82/8109]**PEER REVIEWED**

F104


H104

@ 25 degrees C MEYLAN,WM & HOWARD,PH (1991)

K104


M104


O104

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth Ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)]**QC REVIEWED**

A105

Toxaphene Synonyms: alltox chlorinated-camphene geniphene penphene phenacide toxadust toxakil

D105

[U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5., p. ]**PEER REVIEWED**

H105

@ 20 degrees C [Murphy TJ et al; Environ Sci Technol 21: 155-62 (1987)]**PEER REVIEWED**

M105

FISK,AT ET AL. (1999); median value

O105

@ 20 degrees C [Murphy TJ et al; Environ Sci Technol 21: 155-62 (1987)]**PEER REVIEWED**

A106

Trichlorophenol, 2,4,5 Synonyms: COLLUNOSOL DOWICIDE 2 DOWICIDE B NCI-C61187 NURELLE PREVENTOL I RCRA WASTE NUMBER U230

D106


F106


H106

SRC determined from its vapor pressure of 0.008 mm Hg at 25 deg C [Dempsey BA, O'Melia CR; pp. 239-73 in Aquatic and Terrestrial Humic Materials. Christman RF, Gjessing ET, eds. Ann Arbor,MI: Ann Arbor Sci (1983)] and water solubility of 1,200 mg/l at 25 deg C [Leunberger C et al; J Environ Sci Technol 19: 1053-58 (1985)] **PEER REVIEWED**

M106


O106

@ 25 degrees C [Leunberger C et al; J Environ Sci Technol 19: 1053-58 (1985)]**PEER REVIEWED**

A107

Trichlorophenol 2,4,6 Synonyms: Dowicide 2S NCI-C02904 Omal phenachlor Phenol, 2,4,6-trichloro- RCRA waste number U231

D107


F107


H107

SRC determined from its vapor pressure of 0.008 mm Hg at 25 deg C [Bidleman TF, Renberg L; Chemosphere 14: 1475-81 (1985)] and water solubility of 800 mg/l at 25 deg C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona - Tucson, AZ (1992)] **PEER REVIEWED**

M107


O107

@ 25 degrees C [Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1644]**PEER REVIEWED**

A108

Trimethylbenzene, 1,2,4- Synonyms: Pseudocumene

D108


F108


H108

Sanemasa I et al; Bull Chem Soc Jpn 55: 1054-62 (1982) **PEER REVIEWED**

K108


M108


O108

@ 25 degrees C [McAuliffe C; J Phys Chem 70: 1267-75 (1966)]**PEER REVIEWED**

A109

Trimethylbenzene, 1,3,5- Synonyms: Mesitylene

D109


F109


H109

Sanemasa I et al; Bull Chem Soc Jpn 55: 1054-62 (1982) **PEER REVIEWED**

K109

Schwarzenbach RP, Westall J; Environ Sci Technol 15: 1360-67 (1981) **PEER REVIEWED**

M109


O109

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona-Tucson, AZ. PC Version. (1992)]**PEER REVIEWED**

A110

Trinitrobenzene, 1,3,5-Synonyms: BENZENE, 1,3,5-TRINITRO- RCRA WASTE NUMBER U234 TNB TRINITROBENZEEN TRINITROBENZENE 1,3,5-Trinitrobenzene TRINITROBENZOL sym- Trinitrobenzene

D110

[Weast, R.C. and M.J. Astle. CRC Handbook of Data on Organic Compounds. Volumes I and II. Boca Raton, FL: CRC Press Inc. 1985., p. V1 186]**PEER REVIEWED**

F110


H110

@ 25 degrees C MEYLAN,WM & HOWARD,PH (1991)

K110


M110


O110


A111

Vinyl Acetate Synonyms: ACETIC ACID ETHENYL ESTER ACETIC ACID, ETHENYL ESTER ACETIC ACID VINYL ESTER 1-ACETOXYETHYLENE ETHENYL ACETATE HSDB 190 NSC 8404 UN 1301 VAC VINYL ACETATE, INHIBITED VINYL A MONOMER VYAC

D111


F111


H111

SRC determined from vapor pressure [Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals: Data Compilation. Design Institute Phys Prop Data, Amer Inst Chem Eng. NY,NY: Hemisphere Pub Corp (1989)] and water solubility values [Riddick JA et al; Techniques of Chemistry: Organic Solvents, Physical Properties and Methods of Purification. 4th ed. NY,NY: John Wiley & Sons (1986)] **PEER REVIEWED**

M111


O111

@ 20 degrees C [Riddick, J.A., W.B. Bunger, Sakano T.K. Techniques of Chemistry 4th ed., Volume II. Organic Solvents. New York, NY: John Wiley and Sons., 1985., p. ]**PEER REVIEWED**

A113

Antimony Synonyms: ANTIMONY BLACK ANTIMONY POWDER ANTIMONY, REGULUS ANTYMON C.I. 77050 STIBIUM UN 2871

D113


F113


M113


O113

@ 25 degrees C MEYLAN,WM ET AL. (1996)

A114

Arsenic Synonyms: Arsenic, inorganic gray-arsenic

D114


F114

Values were taken from CRC Handbook of Chemistry and Physics, 85th ed., 2004-2005. Section 4. Properties of the Elements and Inorganic Compounds. Table of "Physical constants of inorganic compounds", pp. 4-37 to 4-96. Triple point for inorganic (gray) arsenic at 3.70 MPa. The triple point indicates the temperature at which solid, liquid, and gas are in equilibrium at a pressure greater than one atmosphere (i.e., the normal melting point does not exist).

M114


O114

MEYLAN,WM ET AL. (1996)

A115

Barium & Compounds Synonyms: UN 1399 or UN 1400 or UN 1854

D115


F115


M115


O115


A116

Beryllium & Compounds Synonyms: Beryllium-9 Glucinum RCRA waste number P015 UN 1567

D116


F116


M116


O116


A117

Cadmium Synonyms: C.I. 77180 KADMIUM

D117


F117


M117


O117


A118

Chromium (III) Synonyms: Chromic ion Chromium (III) ion

O118

CRC Handbook of Chemistry and Physics, 85th ed., 2004-2005. Section 4. Properties of the Elements and Inorganic Compounds. Table of "Physical constants of inorganic compounds", pp. 4-37 to 4-96. Considered insoluble, therefore, a value of 0 was given based on the qualitative solubility in water statement.

A119

Chromium (IV) Synonyms: Chromium (VI) ion

O119

CRC Handbook of Chemistry and Physics, 85th ed., 2004-2005. Section 4. Properties of the Elements and Inorganic Compounds. Table of "Physical constants of inorganic compounds", pp. 4-37 to 4-96. Measured at 25 degrees Celsius.

D121


F121

[Lide, D.R. (ed.). CRC Handbook of Chemistry and Physics. 83rd ed. Boca Raton, Fl: CRC Press Inc., 2002-2003., p. 4-53]**PEER REVIEWED**

O121

Lange's Handbook of Chemistry (15th Edition), Edited by: Dean, J.A., McGraw-Hill, 1999. Table 3.2 Physical Constants of Inorganic Compounds., p.3.2. Considered insoluble, therefore, a value of 0 was given based on the qualitative solubility in water statement.

A122

Cyanide, Free Synonyms: CARBON NITRIDE ION CYANIDE CYANIDE ANION CYANIDE ION CYANURE ISOCYANIDE RCRA WASTE NUMBER P030

M122


O122


A123

Fluorine Synonyms: Fluoride Fluoride ion Fluoride ion(1-) Fluorine, ion Hydrofluoric acid, ion(1-) Perfluoride Soluble Fluoride

D123


F123


M123


O123

@ 25 degrees C [McCrady, JK; Bull Environ Contam Toxicol 34: 634-44 (1985)]**PEER REVIEWED**

A124

Mercury Synonyms: hydragyrum Mercury, elemental Mercury, inorganic Mercury, metallic Mercury (organo) alkyl compounds Caswell No. 546 COLLOIDAL MERCURY EPA Pesticide Chemical Code 052301 Liquid Silver Mercury compounds Mercury vapor NCI-C60399 Quicksilver

D124


F124


M124

DAYLIGHT (1999)

O124

@ 25 degrees C ROSENBLATT,DH ET AL. (1975)

A125

Nickel, Soluable Salts Synonyms: C.I. 77775 NICHEL

A126

Selenium & Compounds Synonyms: C.I. 77805 Caswell No. 732 ELEMENTAL SELENIUM EPA Pesticide Chemical Code 072001 HSDB 4493 SELENIUM ALLOY SELENIUM BASE SELENIUM DUST SELENIUM ELEMENTAL SELENIUM HOMOPOLYMER UN 2658 13410-01-0 Selenic acid, disodium salt Caswell No. 791 Disodium selenate EPA Pesticide Chemical Code 072002 NSC 378348 Selenic acid, disodium salt Sodium selenate 10102-18-8 Selenious acid, disodium salt DISODIUM SELENITE DISODIUM SELENIUM TRIOXIDE HSDB 768 SELENIOUS ACID, DISODIUM SALT SODIUM SELENITE UN 2630 7783-00-8 Selenious acid HSDB 6065 MONOHYDRATED SELENIUM DIOXIDE Selenious Acid 7783-08-6 Selenic acid HSDB 675 Selenic acid UN 1905 1313-85-5 Sodium selenide [Na2Se] Disodium monoselenide Sodium selenide

D126


F126


M126


O126


A127

Silver Synonyms: ARGENTUM CREDE COLLARGOL

D127


F127


M127


O127


D128


F128


M128


O128


D129


F129


O129

CRC Handbook of Chemistry and Physics, 85th ed., 2004-2005. Section 4. Properties of the Elements and Inorganic Compounds. Table of "Physical constants of inorganic compounds", pp. 4-37 to 4-96. Considered insoluble, therefore, a value of 0 was given based on the qualitative solubility in water statement.

A130

Zinc & Compounds Synonyms: Asarco L 15 Blue powder EMANAY ZINC DUST GRANULAR ZINC HSDB 1344 JASAD Lead refinery vacuum zinc Merrillite UN 1436 ZINC DUST ZINC POWDER ZINC, ashes ZINC, powder or dust, non-pyrophoric ZINC, powder or dust, pyrophoric

D130


F130

[Desktop Analysis Tool for Common Data Base, Report to the National Science Foundation by Chemical Abstract Services and American Chemical Society, 1968., p. V25793]**PEER REVIEWED**

M130


O130


D132

[Verschueren, K. Handbook of Environmental Data on Organic Chemicals. Volumes 1-2. 4th ed. John Wiley & Sons. New York, NY. 2001, p. 1515]**PEER REVIEWED**

F132

DEAN,J.A.; LANGE'S HANDBOOK OF CHEMISTRY 13TH ED.; NY, NY: MCGRAW-HILL BOOK CO.; 1985

H132

@ 25 degrees C [Altschuh J et al; Chemosphere 39: 1871-87 (1999) ]**PEER REVIEWED**

K132

Average of range from 4400 to 8500. Sabljic A et al; Chemosphere 31: 4489-4514 (1995) Sablic A, Protic M; Bull Environ Contam Toxicol 28: 162-5 (1982) **PEER REVIEWED**

M132


O132

@ 25 degrees C [Yalkowsky SH, Dannenfelser RM; The Aquasol Database of Aqueous Solubility. Ver 5. Tucson, AZ: Univ AZ, College of Pharmacy (1992) ]**PEER REVIEWED**

D133


F133


H133

SRC determined from experimental values for vapor pressure [Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals: Data Compilation, NY: Hemisphere Pub Corp (1991)] and water solubility [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona-Tucson, AZ. PC Version (1992)] **PEER REVIEWED**

K133

SRC determined from a measured water solubility [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona-Tucson, AZ. PC Version (1992)] and a recommended regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M133


O133

@ 20 degrees C [Yalkowsky SH, Dannenfelser RM; Aquasol Database of Aqueous Solubility. Version 5. College of Pharmacy, University of Arizona-Tucson, AZ. PC Version. (1992)]**PEER REVIEWED**

A134

Acenaphthylene Synonyms: Cyclopenta(de)naphthalene HSDB 2661 NSC 59821

D134

[Weast, R.C. (ed.) Handbook of Chemistry and Physics. 69th ed. Boca Raton, FL: CRC Press Inc., 1988-1989., p. C-42]**PEER REVIEWED**

H134

FENDINGER,N.J.; GLOTFELTY,D.E.; HENRY'S LAW CONSTANTS FOR SELECTED PESTICIDES, PAHS AND PCBS.; ENVIRON. TOXICOL. CHEM.; 9:731-5; 1990

K134

Averege of calculated range of 2055 to 3230. Lyman WJ et al; Handbook of Chemical Property Estimation Methods NY: McGraw-Hill p. 4-9 (1982) **PEER REVIEWED**

M134


O134

@ 25 degrees C WALTERS,RW & LUTHY,RG (1984A)

A135

Benzo(ghi)perylene Synonyms: HSDB 6177 NSC 89275 1,12-Benzoperylene 1,12-benzperylene

D135


F135

[YALKOWSKY SH, VALVANI SC; J CHEM ENG DATA 24: 127 (1979)]**PEER REVIEWED**

H135

[Ten Hulscher TEM et al; Environ Toxicol Chem 11: 1595-1603 (1992)]**PEER REVIEWED**

K135

SRC determined from a log Kow of 6.63 [Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, And Steric Constants. ACS Prof Ref Book. Washington,DC: Amer Chem Soc (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington,DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M135


O135


D136


F136


M136


O136

MEYLAN,WM ET AL. (1996)

A137

Dimethyl phthalate Synonyms: 1,2-benzenedicarboxylic acid, dimethyl ester dimethyl 1,2-benzenedicarboxylate dimethyl benzene-o-dicarboxylate DMP methyl phthalate phthalic acid, dimethyl ester

D137


F137


H137

SRC estimated from experimental values for vapor pressure of 3.08X10-3 mm Hg [Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals: Data Compilation. Design Inst Phys Prop Data, Amer Inst Chem Eng., NY,NY: Hemisphere Pub Corp, Vol 4 (1989)] **PEER REVIEWED**

K137

Average of range from 80 to 360. Banerjee P et al; Chemosphere 14: 1057-67 (1985) **PEER REVIEWED**

M137


O137

@ 25 degrees C HOWARD,PH ET AL. (1985)

D138


F138


H138

[SRC; The Physical Properties Database (PHYSPROP). Syracuse, NY: Syracuse Res Corp. Available from http://www.syrres.com/esc/physprop.htm as of Mar 3, 2006. ]**PEER REVIEWED**

K138

SRC determined from a log Kow of 1.38 [Hansch C, Leo, A; Exploring QSAR Fundamentals and Applications in Chemistry and Biology. Washington, DC: Amer Chem Soc (1995)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M138


O138

@ 20 degrees C [Yalkowsky, S.H., He, Yan., Handbook of Aqueous Solubility Data: An Extensive Compilation of Aqueous Solubility Data for Organic Compounds Extracted from the AQUASOL dATAbASE. CRC Press LLC, Boca Raton, FL. 2003., p. 301]**PEER REVIEWED**

D139


F139


H139

[US EPA; Estimation Programs Interface (EPI). ver. 3.10. U.S. EPA version for Windows. Washington, DC: U.S. EPA (2001). Available at http://www.epa.gov/opptintr/exposure/docs/episuite.htm as of March 3, 2004. ]**PEER REVIEWED**

K139

Average of range from 2450 to 2510. Vowles PD, Mantoura RFC; Chemosphere 16: 109-16 (1987) Hodson J, Williams NA; Chemosphere 17: 67-7 (1988) Gao C et al; Environ Toxicol Chem 15: 1089-96 (1996) Rathbun RE; Crit Rev Environ Sci Technol 30: 129-295 (2000) Schwarzenbach RP, Westall J; Environ Sci Technol 15: 1360-7 **PEER REVIEWED**

M139

DEBRUIJN,J ET AL. (1989)

O139

@ 25 degrees C YALKOWSKY,SH & HE,Y (2003)

D140


F140


H140


K140

Average of range from 495 to 955. Vowles PD, Mantoura RFC; Chemosphere 16: 109-16 (1987) Szabo G et al; Chemosphere 21: 729-39 (1990) SRC determined from molecular connectivity indices [Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992)] **PEER REVIEWED**

M140

SANGSTER (1994)

O140

@ 25 degrees C TEWARI,YB ET AL (1982A)

A141

Phenanthrene Synonyms: HSDB 2166 NSC 26256

D141


F141

[Weast, R.C. (ed.) Handbook of Chemistry and Physics. 67th ed. Boca Raton, FL: CRC Press, Inc., 1986-87., p. C-402]**PEER REVIEWED**

H141

BAMFORD,HA ET AL. (1999)

K141

Syracuse Research Corporation (SRC)

M141


O141

@ 30 degrees C [Verschueren, K. Handbook of Environmental Data of Organic Chemicals. 2nd ed. New York, NY: Van Nostrand Reinhold Co., 1983., p. 970]**PEER REVIEWED**

D142


F142


H142

SRC derived from its vapor pressure, 1.5 mm Hg [Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals Data Compilation Washington, DC: Taylor and Francis (1989)] and water solubility, 23.4 mg/l [Banerjee S et al; Environ Sci Technol 11: 1227-29(1980)] **PEER REVIEWED**

K142


M142


O142

@ 25 degrees C BANERJEE,S ET AL (1980)

D143


F143


H143

[US EPA; Estimation Programs Interface (EPI). ver. 3.10. U.S. EPA version for Windows. Washington, DC: U.S. EPA (2001). Available at http://www.epa.gov/opptintr/exposure/docs/episuite.htm as of March 3, 2004. ]**PEER REVIEWED**

K143

SRC determined from a log Kow of 4.57 [Sherblom PM, Eganhouse RP; J Chromatogr 454: 37-50 (1988)] and a regression-derived equation [Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9 (1990)] **PEER REVIEWED**

M143

SHERBLOM,PM & EGANHOUSE,RP (1988)

O143

@ 25 degrees C [Yalkowsky, S.H., He, Yan., Handbook of Aqueous Solubility Data: An Extensive Compilation of Aqueous Solubility Data for Organic Compounds Extracted from the AQUASOL dATAbASE. CRC Press LLC, Boca Raton, FL. 2003., p. 679]**PEER REVIEWED**

D144


F144


H144

Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992) **PEER REVIEWED**

K144


M144


O144


ChemicalGI (oral) Adsorption IRIS Critical Study

Adjust for dermal?Study reference Study Year Study Species Dosing Regimen % Adsorbed Study Species Dosing Regimen Toxicity FactorOrganics

Chlordane Ewing; Ohno 1985; 1986 rat assume aqueous gavage 80% Mice diet; inhalation SF; RfD NoDichlorophenoxyacetic acid, 2,4 - Knopp; Pelletier 1992; 1989 rat assume aqueous gavage >90% Rat diet RfD NoDichlorodiphenyltrichloroethane (DDT) Keller 1980 rat vegetable oil 70-90% rat dissolved in oil, mixed in diet RfD NoPentachlorophenol Korte; Meerman 1978; 1983 rat diet; water 76%; 100% rat diet RfD NoPolychlorinated Biphenyls Albro; Muhlebach 1972; 1981 rat squalene; emulsion 96%; 80% Rat diet SF NoPolycyclic Aromatic Hydrocarbons Chang; Hecht 1943; 1979 rat diet; water 89% mice diet SF NoAll Other Organic Chemicals multiple multiple multiple multiple generally >50% multiple multiple RfD or SF No

InorganicsAntimony Waitz 1965 rat water 15% rat water RfD YesArsenic, Inorganic Bettley 1975 human assume aqueous 95% human water SF NoBarium and Compounds Cuddihy and Griffith; Taylor 1972; 1962 dog water 7% human water RfD YesBeryllium and Compounds Reeves 1965 rat water 0.70% rat water RfD YesCadmium IRIS 1999 human diet/water 2.5%; 5% human diet/water RfD YesChromium (III) Donaldson and Barreras; Keim 1996; 1987 rat diet/water 1.30% rat diet RfD YesChromium (VI) Donaldson and Barreras; MacKenzie; Sayato 1996; 1959; 1980 rat water 2.50% rat water RfD YesMercury (elemental) ATSDR 1999 human acute inhalation of Hg vapor 74%-80% human inhalation RfC NoMethyl Mercury Aberg 1969 human aqueous 95.00% human diet RfD NoNickel (Soluble Salts) Elakhovskaya 1972 human diet/water 4.00% rat diet RfD YesSelenium and Compounds Young 1982 human diet 30-80% human diet RfD NoSilver Furchner; IRIS 1968; 1999 dog aqueous 4.00% human IV dose RfD YesThallium Lie 1960 rat aqueous 100% rat water gavage RfD NoVanadium Conklin 1982 rat gavage 2.60% rat diet RfD YesZinc and Compounds ATSDR 1994b human diet highly variable human diet supplement RfD No

Reference:U.S.EPA (2004). Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual, Part E, Supplemental Guidance for Dermal Risk Assessment. EPA/540/R/99/005. July 2004.

B1

VAP: For Chemicals of Concern (COCs) not included here and for COCs for which adjustment is not recommended, a default oral absorption value of 1 (100%) is assumed.

A4


B4

Ewing, A.D., Kadry, A.M., and Dorough H.W. 1985. Comparative Disposition and Elmination of Chlordane in Rats and Mice. Toxicol. Lett. 26: 233-239. Ohno, Y., Kawanishi, T., and Takahashi, A. 1986. Comparisons of the Toxicokinetic Parameters in Rats Determined for Low and High Dose gamma-Chlordane. J. Toxicol. Sci. 11: 111-124.

A5


B5

Knopp, D. and Schiller, F. 1992. Oral and Dermal Application of 2,4-Dichlorophenoxyacetic Acid Sodium and Dimethylamine Salts to male rats: Investigation on Absortion and Excretion as Well as Induction of Hepatic Mixed-finction Oxidase Activities. Arch Toxicol. 66: 170-174. Pelletier, O., Ritter L., and Somers, C.J. 1989. Disposition of 2,4-Dichlorophenoxyacetic Acid Dimethlyamine by Fischer 344 Rats Dosed Orally and Dermally. J. Toxicol. Environ. Health 28: 221-234.

A6


B6

Keller, W. and Yeary, R. 1980. A comparison of the Effects of Mineral Oil, Vegetable Oil, and Sodium Sulfate on the Intestinal Absorption of DDT in Rodents. Clin. Toxicol. 16: 223-231.

A7


B7

Kort, F. 1978. Ecotoxicological Profile Analysis. Chemisphere 1: 79-102. Meerman, J.H., Sterenborg, H.M., and Mulder, G.J. 1983. Use of Pentachlorophenol as Long-term Inhibitor of Sulfation of Phols and Hydroaximic Acids in the Rat In-vivo. Biochem. Pharmacol. 32: 1587-1593.

A8


B8

Albro, P.W. and Fishbein, L. 1972. Intestinal Absorption of Polychlorinated Biphenyls in Rats. Bull. Environ. Contam. Toxicology 8: 26-31. Muhlebach, S. 1981. Pharmacokinetics in Rats of 2,4,5,2,4,5 Hexachlorobiphenyl and Unmetabolizable Lipophilic Model Compounds. Xenobioticai 11: 249-257.

B9

Chang, L.H. 1943. The Fecal Excretion of Polycyclic Hydrocarbons Following Their Administration to the Rat. J. Biochemistry 151: 93-99. Hecht, S.S., Gabrowski, W., and Groth, K. 1979. Analysis of Feces for Benzo(a)pyrene After Consumption of Charcoal-broiled Beef by Rats and Humans. Cosmet. Toxicology 17: 223-227.

A12


B12

Waitz, J.A., Ober, R.E., Meisenhelder, J.E., and Thompson, P.E. 1965. Physiological Disposition of Antimony After Administration of 124Sb-labeled Tartar Emetic to Rats, Mice, and Monkeys, and the Effects of tris (p-aminophenyl) Carbonium Pamoate on this Distribution. Bull. World Health Organizationi 33: 537-546.

A13


B13

Bettley, F.R. and O'Shea, J.A. 1975. The Absorption of Arsenic and its Relation to Carcinoma. Brit. J. Dermatol. 92: 563-568.

A14


B14

Cuddihy, R.G. and Griffith, W.C. 1972. A Biological Model Describing Tissue Distribution and Whole-body Retention of Barium and Lanthanum in Beagle Dogs After inhalation and Gavage. Health Phys. 23: 621-633. Taylor, D.M., Bligh, P.H., and Duggan, M.H. 1962. The Absorption of Calcium, Strontium, Barium, and Radium from the Gastrointestinal Tract of the Rat. Biochem. J. 83: 25-29.

A15


B15

Reeves, A.L. 1965. The Absorption of Beryllium from the Gastrointestinal Tract. Arch Environ. Health 11: 209-214.

A16


A17


B17

Donaldson, R.M. and Barraras, R.F. 1996. Intestinal Absorption of Trace Quantities of Chromium. J. Lab. Clin. Med. 68: 484-493. Keim, K.S., Halloway, C.L., and Hebsted, M. 1987. Absorption of Chromium as Affected by Wheat Bran. Cereal Chem. 64: 352-355.

A18


B18

Donaldson, R.M. and Barraras, R.F. 1996. Intestinal Absorption of Trace Quantities of Chromium. J. Lab. Clin. Med. 68: 484-493. MacKenzie, R.D., Anwar, R.A., Beyerrum, R.U., and Hoppert, C.A. 1959. Absorption and Distribution of Cr51 in the Albino Rat. Arch. Biochem. Biophys. 79: 200-205. Sayato, Y., Nakamuro, K., Matasui, S., and Ando, M. 1980. Metabolic Fate of Chromium Compounds. I. Comparative Behavior of Chromium in Rat Administered with Na251CrO4 and 51CrCl3. J. Pharm. Dyn. 3: 17-23.

A19


B19

Agency for Toxic Substances and Disease Registry. 1999. Toxicological Profile for Mercury. U.S. Department of Health & Human Services, Public Health Service.

B20

Aberg, B., Ekman, L., Falk, R., Greitx, U., Persson, G., and Snihs, J. 1969. Metabolism of Methyl Mercury (203Hg) Compounds in Man. Arch Environ. Health 19: 453-484.

A21


B21

Elakhovskaya, N.P. 1972. The Metabolism of Nickel Entering the Organism with Water. (Russian Translation) Gig Sanit 6: 20-22.

A22


B22

Young, V.R., Nahapetian, A., and Janghorbani, M. 1982. Selenium Bioavailability with Reference to Human Nutrition. Am. J. Cli. Nutr. 35: 1076-1088.

A23


B23

Furchner, J.E., Richmond, C.R., and Drake, G.A. 1968. Comparative Metabolism of Radionuclides in Mammals-IV. Retention of Silver-110m in the Mouse, Rat, Monkey, and Dog. Health Phys. 6: 505-524.

B24

Lie, R., Thomas, R.G., and Scot, J.K. 1960. The Distribution and Excretion of Thanllium204 in the Rat Suggested MPCs and a Bioassay Procedure. Health Phys. 2: 334-340.

B25

Conklin, A.W., Skinner, S.C., Felten, T.L., and Sanders, C.L. 1982. Clearance and Distribution of Intratracheally Instilled Vanadium Compounds in the Rat. Toxicol. Lett. 11: 199-203.

A26


B26

Agency for Toxic Substances and Disease Registry. 1994b. Toxicological Profile for Zinc. U.S. Depratment of Health & Human Services, Public Health Service.

ChemicalCAS Derm/Oral

Assess?Number (%)Volatile Organic CompoundsAcetone 67-64-1 - NBenzene 71-43-2 15% YCarbon Disulfide 75-15-0 18% YCarbon Tetrachloride 56-23-5 27% YChlorobenzene 108-90-7 36% YChloroethane 75-00-3 6% NChloroform 67-66-3 9% NDibromochloromethane 124-48-1 - NDichlorodifluoromethane 75-71-8 12% YDichloroethane, 1,1 - 75-34-3 8% NDichloroethane, 1,2 - 107-06-2 5% NDichloroethene, 1,1 - 75-35-4 14% Y

156-59-2 - N156-60-5 9% N

Dichloropropane, 1,2 - 78-87-5 10% NDichloropropene, 1,3 - 542-75-6 5% NDioxane, 1,4 - 123-91-1 0% NEthyl Ether 60-29-7 2% NEthylbenzene 100-41-4 61% YFormaldehyde 50-00-0 1% NFormic acid 64-18-6 - N

110-54-3 - NIsobutyl Alcohol 78-83-1 - NMethanol 67-56-1 0% NMethyl Ethyl Ketone (MEK) 78-93-3 - NMethyl Isobutyl Ketone (MIBK) 108-10-1 - N

1634-04-4 - NMethylene Chloride 75-09-2 4% NStyrene 100-42-5 45% YTetrachloroethane , 1,1,1,2 - 630-20-6 - NTetrachloroethane, 1,1,2,2 - 79-34-5 13% YTetrachloroethene 127-18-4 60% YToluene 108-88-3 35% YTrichloroethane, 1,1,1 - 71-55-6 19% YTrichloroethane, 1,1,2 - 79-00-5 9% NTrichloroethene 79-01-6 17% YTrichlorofluoromethane 75-69-4 19% YTrichloropropane, 1,2,3 - 96-18-4 - NVinyl Chloride 75-01-4 5% NXylenes, Total 1330-20-7 65% YSemi-Volatile Organic CompoundsAcenaphthene 83-32-9 - NAcetophenone 98-86-2 - NAcrylonitrile 107-13-1 1% NAniline 62-53-3 2% NAnthracene 120-12-7 - NBenzidine 92-87-5 2% N


Hexane, n -


Benzo(a)anthracene 56-55-3 1283% YBenzo(a)pyrene 50-32-8 2186% YBenzo(b)fluoranthene 205-99-2 2221% YBenzo(k)fluoranthene 207-08-9 - NBis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 - NButyl Benzyl Phthalate 85-68-7 - NCarbazole 86-74-8 - NChlordane 57-74-9 231% YChrysene 218-01-9 1283% YDibenz(a,h)anthracene 53-70-3 3388% YDichlorobenzene, 1,2 - (o) 95-50-1 66% YDichlorobenzene, 1,4 - (p) 106-46-7 67% YDichlorobenzidine, 3,3 - 91-94-1 41% YDichlorodiphenyldichloroethane (DDD) 72-54-8 703% YDichlorodiphenyldichloroethene (DDE) 72-55-9 602% YDichlorodiphenyltrichloroethane (DDT) 50-29-3 1156% YDichlorophenoxyacetic acid, 2,4 - 94-75-7 - NDiethyl Phthalate 84-66-2 10% YDimethylphenol, 2,4 - 105-67-9 15% YDi-n-butyl Phthalate 84-74-2 81% Y

99-65-0 - NDinitrobenzene, 1,2 - 528-29-0 - NDinitrotoluene, 2,4 - 121-14-2 6% NDinitrotoluene, 2,6 - 606-20-2 4% NEndrin 72-20-8 71% YEthylene Glycol 107-21-1 - NFluoranthene 206-44-0 512% YFluorene 86-73-7 - NHeptachlor 76-44-8 48% YHeptachlor Epoxide 1024-57-3 - NHexachloro- 1,3 - Butadiene 87-68-3 243% YHexachlorobenzene 118-74-1 469% YHexachloroethane 67-72-1 86% YIndeno(1,2,3-c,d)pyrene 193-39-5 2307% YIsophorone 78-59-1 5% NIsopropylbenzene (Cumene) 98-82-8 - NLindane 58-89-9 40% Ym-cresol 108-39-4 10% NMethoxychlor 72-43-5 - NMethylnaphthalene, 1 - 90-12-0 - NNaphthalene 91-20-3 66% YNitrobenzene 98-95-3 - N

86-30-6 32% Yo-cresol 95-48-7 10% N

117-84-0 - Np-cresol 106-44-5 10% NPentachlorophenol 87-86-5 1226% YPhenol 108-95-2 5% NPolychlorinated Biphenyls 1336-36-3 - NPyrene 129-00-0 - N




Pyridine 110-86-1 - NSilvex (2,4,5-T) 93-72-1Toxaphene 8001-35-2 85% YTrichlorophenol, 2,4,5 - 95-95-4 - NTrichlorophenol, 2,4,6 - 88-06-2 77% YTrimethylbenzene, 1,2,4 95-63-6 - NTrimethylbenzene, 1,3,5 108-67-8 - NTrinitrobenzene, 1,3,5 - (s) 99-35-4 - NVinyl Acetate 108-05-4 - NInorganic AnalytesAntimony 7440-36-0 3.50% NArsenic, Inorganic 7440-38-2 0.55% NBarium and Compounds 7440-39-3 7.50% NBeryllium and Compounds 7440-41-7 75% YCadmium 7440-43-9 21% YChromium (III) 16065-83-1 40.38% YChromium (VI) 18540-29-9 42% YChromium (Total) NA - -Cobalt 7440-48-4 - NCyanide, Free 57-12-5 - NFluorine (soluble fluoride) 7782-41-4 - NMercury 7439-97-6 7.50% NNickel (Soluble Salts) Various 2.62% NSelenium and Compounds 7782-49-2 1.75% NSilver 7440-22-4 7.88% NThallium 7440-28-0 0.52% NVanadium 7440-62-2 20.19% YZinc and Compounds 7440-66-6 highly variable

Reference:U.S.EPA (2004). Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual, Part E, Supplemental Guidance for Dermal Risk Assessment. EPA/540/R/99/005. July 2004.

OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)TOXICITY FACTORS FOR CHEMICALS OF CONCERN

CAS REFERENCE DOSES (RfD) & REFERENCE CONCENTRATIONS (RfC) Number Oral Oral (Construction) Inhalation Inhalation (Construction)

(mg/kg-day) Source (mg/kg-day) Source Source Source

Volatile Organic CompoundsAcetone 67-64-1 9.00E-01 IRIS 2.70E+00 IRIS 3.09E+01 ATSDR 3.09E+01 ATSDRBenzene 71-43-2 4.00E-03 IRIS 1.20E-02 IRIS 3.00E-02 IRIS 9.00E-02 IRISCarbon Disulfide 75-15-0 1.00E-01 IRIS 1.00E-01 HEAST 7.00E-01 IRIS 2.00E-01 HEASTCarbon Tetrachloride 56-23-5 7.00E-04 IRIS 7.00E-03 ATSDR 2.00E-03 NCEA 2.00E-02 NCEAChlorobenzene 108-90-7 2.00E-02 IRIS 2.00E-01 IRIS 5.00E-02 NCEA 5.00E-01 NCEAChloroethane 75-00-3 4.00E-01 NCEA 4.00E-01 NCEA 1.00E+01 IRIS 1.00E+01 IRISChloroform 67-66-3 1.00E-02 IRIS 1.00E-01 ATSDR 1.00E-01 ATSDR 2.40E-01 ATSDRDibromochloromethane 124-48-1 2.00E-02 IRIS 2.00E-01 IRIS NA NA NA NADichlorodifluoromethane 75-71-8 2.00E-01 IRIS 9.00E-01 HEAST 2.00E-01 HEAST 2.00E+00 HEASTDichloroethane, 1,1 - 75-34-3 2.00E-01 NCEA 2.00E+00 NCEA 5.00E-01 HEAST 1.43E+00 HEASTDichloroethane, 1,2 - 107-06-2 2.00E-02 NCEA 2.00E-01 ATSDR 2.43E+00 ATSDR 2.43E+00 ATSDRDichloroethene, 1,1 - 75-35-4 5.00E-02 IRIS 9.00E-03 HEAST 2.00E-01 IRIS 2.00E-01 IRIS

156-59-2 1.00E-02 NCEA 1.00E-01 NCEA NA NA NA NA156-60-5 2.00E-02 IRIS 2.00E-01 IRIS 6.00E-02 NCEA 6.00E-02 NCEA

Dichloropropane, 1,2 - 78-87-5 9.00E-02 ATSDR 7.00E-02 ATSDR 4.00E-03 IRIS 1.30E-02 HEASTDichloropropene, 1,3 - 542-75-6 3.00E-02 IRIS 4.00E-02 ATSDR 2.00E-02 IRIS 2.00E-02 IRISDioxane, 1,4 - 123-91-1 1.00E-01 ATSDR 6.00E-01 ATSDR 3.60E+00 ATSDR 3.60E+00 ATSDREthyl Ether 60-29-7 2.00E-01 IRIS 2.00E+00 IRIS NA NA NA NAEthylbenzene 100-41-4 1.00E-01 IRIS 1.00E+00 IRIS 1.00E+00 IRIS 1.00E+00 NCEAFormaldehyde 50-00-0 2.00E-01 IRIS 3.00E-01 ATSDR 1.00E-02 ATSDR 4.00E-02 ATSDRFormic acid 64-18-6 2.00E+00 HEAST 2.00E+00 HEAST 3.00E-03 NCEA 9.00E-03 NCEA

110-54-3 6.00E-02 HEAST 6.00E-01 HEAST 7.00E-01 IRIS 2.10E+00 IRISIsobutyl Alcohol 78-83-1 3.00E-01 IRIS 3.00E+00 IRIS NA NA NA NAMethanol 67-56-1 5.00E-01 IRIS 5.00E+00 IRIS 4.00E+00 Cal/EPA 4.00E+00 Cal/EPAMethyl Ethyl Ketone (MEK) 78-93-3 6.00E-01 IRIS 2.00E+00 HEAST 5.00E+00 IRIS 1.00E+00 HEASTMethyl Isobutyl Ketone (MIBK) 108-10-1 8.00E-02 HEAST 8.00E-01 HEAST 3.00E+00 IRIS 8.00E-01 HEAST

1634-04-4 NA NA 3.00E-01 ATSDR 3.00E+00 IRIS 3.00E+00 IRISMethylene Chloride 75-09-2 6.00E-02 IRIS 6.00E-02 HEAST 1.00E+00 ATSDR 1.00E+00 ATSDRStyrene 100-42-5 2.00E-01 IRIS 2.00E+00 IRIS 1.00E+00 IRIS 3.00E+00 IRISTetrachloroethane , 1,1,1,2 - 630-20-6 3.00E-02 IRIS 3.00E-02 HEAST NA NA NA NATetrachloroethane, 1,1,2,2 - 79-34-5 6.00E-02 NCEA 5.00E-01 ATSDR NA NA NA NATetrachloroethene 127-18-4 1.00E-02 IRIS 1.00E-01 IRIS 2.71E-01 ATSDR 2.71E-01 ATSDRToluene 108-88-3 8.00E-02 IRIS 8.00E-01 IRIS 5.00E+00 IRIS 9.23E-01 NCEATrichloroethane, 1,1,1 - 71-55-6 2.80E-01 NCEA 2.00E+01 ATSDR 2.20E+00 NCEA 2.20E+01 NCEATrichloroethane, 1,1,2 - 79-00-5 4.00E-03 IRIS 4.00E-02 IRIS NA NA NA NATrichloroethene 79-01-6 5.00E-01 Cal/EPA 5.00E-01 Cal/EPA 6.00E-01 Cal/EPA 6.00E-01 Cal/EPATrichlorofluoromethane 75-69-4 3.00E-01 IRIS 7.00E-01 HEAST 7.00E-01 HEAST 7.00E+00 HEASTTrichloropropane, 1,2,3 - 96-18-4 6.00E-03 IRIS 6.00E-02 IRIS NA NA NA NAVinyl Chloride 75-01-4 3.00E-03 IRIS 3.00E-03 IRIS 1.00E-01 IRIS 1.00E-01 IRISXylenes, Total 1330-20-7 2.00E-01 IRIS 2.00E-01 IRIS 1.00E-01 IRIS 1.00E-01 IRIS

Semi-Volatile Organic Compounds

Chemical (Synonyms in comments)

(mg/m3) (mg/m3)


Hexane, n -


B3


E4

VAP: Oral RfD carried over if Subchronic Rfd was unavailable.

I4

VAP: Inhalation RfC carried over if Chronic RfC was unavailable.

A7


D7

VAP: Oral RfD of 0.1 mg/kg-day was updated to 0.9 on 7/31/03

E7

VAP: IRIS chronic value adjusted by removing UF of 3 for extrapolation from subchronic studies.

G7

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 13 ppm. MRL converted to RfC of 30.9 mg/ cu. m

I7

VAP: Based on intermediate (15 to 364 days) inhalation MRL of 13ppm. MRL converted to RfC of 30.9 mg/cu. m

A8


D8

VAP: Old Oral RfD of 1.00E-03 was updated (IRIS) on 4/17/03 to 4.00E-3

E8

VAP: Value based on IRIS Chronic value removing UF of 3 for subchronic to chronic.

H8

VAP: Inhalation RfD was updated (IRIS) from 2.57E-03 mg/kg/d to 3.0E-2 mg/m3 (8.58E-3 mg/kg/d) on 4/17/03.

I8

VAP: IRIS chronic value adjusted by removing UF of 3 for subchronic-to-chronic extrapolation.

A9


A10


E10

VAP: Based on intermediate-duration (15 to 364 days) oral MRL of 0.007 mg/kg/day.

A11


E11


A12


D12

VAP: RAIS references Region 9 and NCEA.

A13


E13


G13

VAP: Based on chronic-duration ( 365 days or greater) inhalation MRL of 0.02 ppm. MRL converted to RfC of 0.1 mg/ cu. m

I13

VAP: Based on intermediate-duration (15 to 364 days) inhalation MRL of 0.05 ppm. MRL converted RfC of 0.24 mg/ cu. m

A14


E14


A15


A16


A17


E17


G17

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 0.6 ppm. MRL converted to RfC of 2.43 mg/cu.m

I17


A18

Dichloroethene, 1,1- Synonyms: 1,1-Dichloroethene 1,1-DCE Dichloroethylene, 1,1- Ethylene, 1,1-dichloro- NCI-C54262 RCRA Waste Number U078 Sconatex UN 1303 Vinylidene chloride Vinylidene dichloride Vinylidine chloride VDC

G18

VAP: NEW IRIS RfC of 2E-1 mg/m3 on 8/13/02

I18

VAP: Subchronic-to-chronic extrapolation factor was not applied because the study exposed the animals for 2 years. A database UF is not applied because the database is considered complete.

A19


A20


E20

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolating from subchronic to chronic exposure.

A21


C21

VAP: Based on chronic-duration (365 days or greater) oral MRL of 0.09 mg/kg/day.

E21


A22


E22


A23


C23


E23


G23

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 1 ppm. MRL converted to RfC of 3.6 mg/cu. m

I23


A24


E24

VAP: Iris Chronic Value adjusted by removing UF of 10 for extrapolation from subchronic to chronic data

A25


E25


A26


E26


G26

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 0.008 ppm. MRL converted to RfC of 0.01 mg/cu. m

I26

VAP: Based on intermediate-duration (15 to 364 days) inhalation MRL of 0.03 ppm. MRL converted to RfC of 0.04 mg/cu. m

A27


A28


H28

VAP: RfC updated from 2.0 E-02 mg/cu. m to 7.0E-01 mg/cu. m on 12/23/2005

I28

VAP: IRIS chronic value adjusted by removing UF of 3 to extrapolate to chronic exposure from data in a less-than lifetime study

A29


E29

VAP: Value based on IRIS Chronic value removing UF of 10 for extrapolating subchronic exposure to chronic exposure.

A30


E30

VAP: Value based on IRIS Chronic value removing UF of 10 (10S) to account for extrapolation from subchronic to chronic exposure.

A31


D31

sbeal: Consistent with EPA practice (U.S. EPA, 1991a), an uncertainty factor was not used to account for extrapolation from less than chronic results because developmental toxicity (decreased pup body weight following in utero and neonatal exposure) was used as the critical effect.

H31

VAP: Old RfC of 0.286 (1 mg/m3) was updated (IRIS) on 9/29/03 to 5 mg/m3 (1.43 mg/kg/d).

A32


H32

VAP: Old RfC of 2.29E-02 was updated (IRIS) to 3 mg/m3 (.858 mg/kg/d) on 4/25/03.

A33


E33


A34


G34


I34


A35


E35


I35

VAP: IRIS chronic value adjusted by removing UF of 3 for lack of information on chronic studies as the average exposure duration of the principal study of Mutti et al. (1984) was not long enough (8.6 years) to be considered chronic

A36


A37


E37


A38

PCE Synonyms: Ankilostin Antisal 1 or Antisol 1 Carbon bichloride Carbon dichloride Czterochloroetylen Dee-Solv Didakene or Didokene Dowclene EC Dow-Per ENT 1,860 Ethene, tetrachloro- Ethylene tetrachloride Ethylene, tetrachloro- Fedal-Un NCI-C04580 Nema PER Perawin PERC Perchloorethyleen, per Perchlor Perchloraethylen, per Perchlorethylene Perchlorethylene, per Perchloroethylene Perclene Percloroetilene Percosolv Percosolve PERK Perklone Persec Tetlen Tetracap Tetrachlooretheen Tetrachloraethen Tetrachlorethylene Tetrachloroethene Tetrachloroethylene 1,1,2,2-Tetrachloroethylene. Tetracloroetene Tetraguer or Tetraleno Tetralex or Tetravec Tetroguer Tetropil WLN: GYGUYGG

E38

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolation of a subchronic effect level to its chronic equivalent

G38

VAP: Value is based on chronic- duration (365 days or greater) inhalation MRL of 0.04 ppm. MRL was converted to RfC of 2.71e-1 mg/m3.

I38


A39


D39

VAP: Oral RfD of 0.2 mg/kg-day was updated to 0.08 mg/kg-day on 9/23/2005.

E39

VAP: IRIS chronic value adjusted by removing UF of 10 10 for use of a subchronic study to estimate chronic effects (UFS; duration of exposure)

A40


E40

VAP: Based on intermediate-duration (15 to 364 days) oral MRL of 20 mg/kg/day.

A41


E41

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolation to lifetime exposure from an intermediate exposure duration.

A42

TCE Synonyms: ACETYLENE TRICHLORIDE ALGYLEN ANAMENTH BENZINOL BLACOSOLV BLANCOSOLV CECOLENE CHLORILEN 1-CHLORO-2,2-DICHLOROETHYLENE CHLORYLEA CHLORYLEN CHORYLEN CIRCOSOLV CRAWHASPOL DENSINFLUAT 1,1-DICHLORO-2-CHLOROETHYLENE DOW-TRI DUKERON ETHINYL TRICHLORIDE ETHYLENE TRICHLORIDE ETHYLENE, TRICHLORO- FLECK-FLIP FLOCK FLIP FLUATE GEMALGENE GERMALGENE LANADIN LETHURIN NARCOGEN NARKOGEN NARKOSOID NCI-C04546 NIALK PERM-A-CHLOR PERM-A-CLOR PETZINOL PHILEX RCRA WASTE NUMBER U228 THRETHYLEN THRETHYLENE TRETHYLENE TRI or TRIAD or TRIAL TRIASOL TRICHLOORETHEEN TRICHLOORETHYLEEN, TRI TRICHLORAETHEN TRICHLORAETHYLEN, TRI TRICHLORAN or TRICHLOREN TRICHLORETHYLENE, TRI TRICHLOROETHENE Trichloroethylene 1,1,2-TRICHLOROETHYLENE 1,2,2-TRICHLOROETHYLENE TRI-CLENE TRICLORETENE TRICLOROETILENE TRIELENE or TRIELIN TRIELINA or TRIKLONE TRILEN or TRILENE TRILINE or TRIMAR TRIOL or TRI-PLUS TRI-PLUS M UN 1710 VESTROL VITRAN WESTROSOL

E42

VAP: New CAL/EPA chronic RfDo of 5.0E-01 w/no UF adjustment has been carried over.

G42

VAP: Based on California EPA Inhalatin Reference Exposure Level of 600 ug/ cu. M (10 ppb).

I42

VAP: OEPA uses Cal/EPA chronic Inhanlation RfD w/ no UF adjustment (subchronic uncertainty of 1).

A43


A44


E44

VAP: Value based on IRIS Chronic value removing UF of 10 for extrapolating subchronic to chronic exposures.

A45


A46


E46

VAP: No subchronic value as of 2/24/03, value is the chronic value.

G46

VAP: Old RfC of 0.123 (ATSDR) was updated to 0.1 mgm3 (0.0286 mg/kg/day) from IRIS on 2/21/03.

I46

VAP: No subchronic value as of 2/24/03, value is the chronic value.

Acenaphthene 83-32-9 6.00E-02 IRIS 6.00E-01 IRIS NA NA NA NAAcetophenone 98-86-2 1.00E-01 IRIS 1.00E+00 IRIS NA NA NA NAAcrylonitrile 107-13-1 4.00E-02 ATSDR 1.00E-02 ATSDR 2.00E-03 IRIS 2.00E-03 IRISAniline 62-53-3 7.00E-03 NCEA 7.00E-03 NCEA 1.00E-03 IRIS 1.00E-02 IRISAnthracene 120-12-7 3.00E-01 IRIS 3.00E+00 IRIS NA NA NA NABenzidine 92-87-5 3.00E-03 IRIS 3.00E-03 HEAST NA NA NA NABenzo(a)anthracene 56-55-3 NA NA NA NA NA NA NA NABenzo(a)pyrene 50-32-8 NA NA NA NA NA NA NA NABenzo(b)fluoranthene 205-99-2 NA NA NA NA NA NA NA NABenzo(k)fluoranthene 207-08-9 NA NA NA NA NA NA NA NABis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 2.00E-02 IRIS 2.00E-01 IRIS NA NA NA NAButyl Benzyl Phthalate 85-68-7 2.00E-01 IRIS 2.00E+00 IRIS NA NA NA NACarbazole 86-74-8 NA NA NA NA NA NA NA NAChlordane 57-74-9 5.00E-04 IRIS 6.00E-05 HEAST 7.00E-04 IRIS 7.00E-03 IRISChrysene 218-01-9 NA NA NA NA NA NA NA NADibenz(a,h)anthracene 53-70-3 NA NA NA NA NA NA NA NADichlorobenzene, 1,2 - (o) 95-50-1 9.00E-02 IRIS 9.00E-02 IRIS 2.00E-01 HEAST 2.00E+00 HEASTDichlorobenzene, 1,4 - (p) 106-46-7 7.00E-02 ATSDR 7.00E-02 ATSDR 8.00E-01 IRIS 2.40E+00 IRISDichlorobenzidine, 3,3 - 91-94-1 NA NA NA NA NA NA NA NADichlorodiphenyldichloroethane (DDD) 72-54-8 2.00E-03 NCEA 2.00E-03 NCEA NA NA NA NADichlorodiphenyldichloroethene (DDE) 72-55-9 NA NA NA NA NA NA NA NADichlorodiphenyltrichloroethane (DDT) 50-29-3 5.00E-04 IRIS 5.00E-04 IRIS NA NA NA NADichlorophenoxyacetic acid, 2,4 - 94-75-7 1.00E-02 IRIS 1.00E-02 HEAST NA NA NA NADiethyl Phthalate 84-66-2 8.00E-01 IRIS 8.00E+00 IRIS NA NA NA NADimethylphenol, 2,4 - 105-67-9 2.00E-02 IRIS 2.00E-01 IRIS NA NA NA NADi-n-butyl Phthalate 84-74-2 1.00E-01 IRIS 1.00E+00 IRIS NA NA NA NA

99-65-0 1.00E-04 IRIS 1.00E-03 IRIS NA NA NA NADinitrobenzene, 1,2 - 528-29-0 1.00E-04 NCEA 1.00E-03 NCEA NA NA NA NADinitrotoluene, 2,4 - 121-14-2 2.00E-03 IRIS 2.00E-03 HEAST NA NA NA NADinitrotoluene, 2,6 - 606-20-2 1.00E-03 NCEA 1.00E-02 NCEA NA NA NA NAEndrin 72-20-8 3.00E-04 IRIS 2.00E-03 ATSDR NA NA NA NAEthylene Glycol 107-21-1 2.00E+00 IRIS 2.00E+00 HEAST 4.00E+00 Cal/EPA 4.00E+00 Cal/EPAFluoranthene 206-44-0 4.00E-02 IRIS 4.00E-01 ATSDR NA NA NA NAFluorene 86-73-7 4.00E-02 IRIS 4.00E-01 IRIS NA NA NA NAHeptachlor 76-44-8 5.00E-04 IRIS 1.00E-04 ATSDR NA NA NA NAHeptachlor Epoxide 1024-57-3 1.30E-05 IRIS 1.30E-05 HEAST NA NA NA NAHexachloro- 1,3 - Butadiene 87-68-3 2.00E-04 HEAST 2.00E-04 ATSDR NA NA NA NAHexachlorobenzene 118-74-1 8.00E-04 IRIS 1.00E-04 NCEA NA NA NA NAHexachloroethane 67-72-1 1.00E-03 IRIS 1.00E-02 IRIS NA NA 5.81E+01 ATSDRIndeno(1,2,3-c,d)pyrene 193-39-5 NA NA NA NA NA NA NA NAIsophorone 78-59-1 2.00E-01 IRIS 2.00E+00 IRIS 2.00E+00 Cal/EPA 2.00E+00 Cal/EPAIsopropylbenzene (Cumene) 98-82-8 1.00E-01 IRIS 3.00E-01 IRIS 4.00E-01 IRIS 4.00E+00 IRISLindane 58-89-9 3.00E-04 IRIS 3.00E-03 IRIS NA NA NA NAm-cresol 108-39-4 5.00E-02 IRIS 5.00E-01 IRIS NA NA NA NAMethoxychlor 72-43-5 5.00E-03 IRIS 5.00E-03 ATSDR NA NA NA NAMethylnaphthalene, 1 - 90-12-0 7.00E-02 ATSDR 7.00E-02 ATSDR NA NA NA NANaphthalene 91-20-3 2.00E-02 IRIS 2.00E-01 IRIS 3.00E-03 IRIS 3.00E-03 IRISNitrobenzene 98-95-3 5.00E-04 IRIS 5.00E-03 IRIS 2.00E-03 HEAST 2.00E-02 HEAST


A48


E48

VAP: IRIS chronic value adjusted by removing UF of 10 for the use of a subchronic study for chronic RfD derivation

A49


E49

VAP: IRIS chronic value adjusted by removing UF of 10 to extrapolate from subchronic to chronic exposure

A50


C50


E50


A51


I51

VAP: Iris Chronic value adjusted by removing UF of 10 for use of a subchronic study

A52


E52

VAP: IRIS chronic value adjusted by removing UF of 10 for subchronic to chronic

A53


A54


A55


A56


A57


A58


E58


A59


E59

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolating from subchronic to chronic NOAELs

A61


I61

VAP: Iris Chronic value adjusted by removing UF of 10 for use of a subchronic study

A62


A63


A64


A65


C65


E65


I65

VAP: IRIS chronic value adjusted by removing UF of 3 since the NOAEL was based on a subchronic rather than chronic study

A66


A67


A68


A69


A70


A71


E71

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolation from subchronic to chronic exposure

A72


E72


A73


E73


A74


E74

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolation from subchronic to chronic exposure

A75


A76


A77


A78


E78


A79


A80


E80


A81


E81


A82


E82


A83


A84


E84


A85


A86


E86

VAP: IRIS chronic value adjusted by removing Uf of 10 for the use of a subchronic study

I86

VAP: Based on intermediate-duration (15 to 364 days) inhalation MRL of 6 ppm. MRL converted to RfC of 58.1 mg/cu. m

A87


A88


E88

VAP: IRIS chronic value adjusted by removing UF of 10 to account for the use of a subchronic study

A89


E89

VAP: IRIS chronic value adjusted by removing UF of 3 for subchronic-to- chronic duration extrapolation

I89

VAP: IRIS chronic value adjusted by removing UF of 10 for subchronic-to-chronic extrapolation

A90


E90

VAP: IRIS chronic value adjusted by removing UF of 10 for use of a subchronic vs. a lifetime assay

A91


E91

VAP: IRIS chronic value adjusted by removing UF of 10 for uncertainty in extrapolation of subchronic data to levels of chronic effects.

A92


E92


C93


E93


A94


E94


A95


E95

VAP: IRIS chronic value adjusted by removing a 10-fold factor for estimating a chronic effect level

86-30-6 2.00E-02 NCEA 2.00E-02 NCEA NA NA NA NAo-cresol 95-48-7 5.00E-02 IRIS 5.00E-01 IRIS NA NA NA NA

117-84-0 4.00E-02 NCEA 4.00E-01 NCEA NA NA NA NAp-cresol 106-44-5 5.00E-03 HEAST 5.00E-03 HEAST NA NA NA NAPentachlorophenol 87-86-5 3.00E-02 IRIS 1.00E-03 ATSDR NA NA NA NAPhenol 108-95-2 3.00E-01 IRIS 6.00E-01 HEAST 2.00E-01 Cal/EPA 2.00E-01 Cal/EPAPolychlorinated Biphenyls 1336-36-3 2.00E-05 IRIS 6.00E-05 IRIS NA NA NA NAPyrene 129-00-0 3.00E-02 IRIS 3.00E-01 IRIS NA NA NA NAPyridine 110-86-1 1.00E-03 IRIS 1.00E-02 IRIS NA NA NA NASilvex 93-72-1 8.00E-03 IRIS 8.00E-03 HEAST NA NA NA NAToxaphene 8001-35-2 NA NA 1.00E-03 ATSDR NA NA NA NATrichlorophenol, 2,4,5 - 95-95-4 1.00E-01 IRIS 1.00E+00 IRIS NA NA NA NATrichlorophenol, 2,4,6 - 88-06-2 NA NA NA NA NA NA NA NATrimethylbenzene, 1,2,4 - 95-63-6 5.00E-02 NCEA 5.00E-02 NCEA 6.00E-03 NCEA 6.00E-03 NCEATrimethylbenzene, 1,3,5 108-67-8 5.00E-02 NCEA 5.00E-01 NCEA 6.00E-03 NCEA 6.00E-02 NCEATrinitrobenzene, 1,3,5 - (s) 99-35-4 3.00E-02 IRIS 5.00E-04 HEAST NA NA NA NAVinyl Acetate 108-05-4 1.00E+00 HEAST 1.00E+00 HEAST 2.00E-01 IRIS 3.50E-02 ATSDR

Inorganic AnalytesAntimony 7440-36-0 4.00E-04 IRIS 2.00E-04 NCEA NA NA 4.00E-04 NCEAArsenic, Inorganic 7440-38-2 3.00E-04 IRIS 3.00E-04 HEAST NA NA NA NABarium and Compounds 7440-39-3 2.00E-01 IRIS 7.00E-02 HEAST 5.00E-04 HEAST 5.00E-03 HEASTBeryllium and Compounds 7440-41-7 2.00E-03 IRIS 5.00E-03 HEAST 2.00E-05 IRIS 2.00E-05 IRISCadmium 7440-43-9 5.00E-04 IRIS 5.00E-04 IRIS NA NA 9.00E-04 NCEAChromium (III) (Insoluble Salts) 16065-83-1 1.50E+00 IRIS 1.50E+00 HEAST NA NA NA NAChromium (VI) 18540-29-9 3.00E-03 IRIS 2.00E-02 HEAST 1.00E-04 IRIS 1.00E-04 IRISChromium (Total) NA NA NA NA NA NA NA NA NACobalt 7440-48-4 2.00E-02 NCEA 2.00E-02 NCEA 2.00E-05 NCEA 2.00E-05 NCEACyanide, Free 57-12-5 2.00E-02 IRIS 2.00E-02 HEAST NA NA NA NAFluorine (soluble fluoride) 7782-41-4 6.00E-02 IRIS 6.00E-02 HEAST NA NA NA NAMercury 7439-97-6 1.00E-04 IRIS 1.00E-04 HEAST 3.00E-04 IRIS 3.00E-04 HEASTNickel (Soluble Salts) Various 2.00E-02 IRIS 2.00E-02 HEAST 9.00E-05 ATSDR 2.00E-04 ATSDRSelenium and Compounds 7782-49-2 5.00E-03 IRIS 5.00E-03 HEAST NA NA NA NASilver 7440-22-4 5.00E-03 IRIS 5.00E-03 HEAST NA NA NA NAThallium 7440-28-0 8.00E-05 IRIS 8.00E-04 IRIS NA NA NA NAVanadium 7440-62-2 9.00E-03 IRIS 9.00E-03 HEAST NA NA NA NAZinc and Compounds 7440-66-6 3.00E-01 IRIS 3.00E-01 ATSDR NA NA NA NA

Supplemental Criteria2-methylnaphthalene 91-57-6 4.00E-03 IRIS 4.00E-03 IRIS 5.00E+00 OEPA 9.23E-01 OEPA4-chlorotoluene 106-43-4 2.00E-02 OEPA 2.00E-01 OEPA NA NA NA NAAcenaphthylene 208-96-8 6.00E-02 OEPA 6.00E-01 OEPA NA NA NA NABenzo(g,h,i)perylene 191-24-2 3.00E-02 OEPA 3.00E-01 OEPA NA NA NA NACopper 7440-50-8 4.00E-02 Region 9 1.00E-02 ATSDR NA NA NA NADimethyl phthalate 131-11-3 8.00E-01 OEPA 8.00E+00 OEPA NA NA NA NAMethyl butyl ketone 591-78-6 8.00E-02 OEPA 8.00E-01 OEPA 3.00E+00 OEPA 8.00E-01 OEPAn-butyl benzene 104-51-8 8.00E-02 OEPA 8.00E-01 OEPA 5.00E+00 OEPA 9.23E-01 OEPAn-propyl benzene 103-65-1 1.00E-01 OEPA 3.00E-01 OEPA 4.00E-01 OEPA 4.00E+00 OEPAPhenanthrene 85-01-8 3.00E-01 OEPA 3.00E+00 OEPA NA NA NA NAp-isopropyltoluene (Cymene) 99-87-6 2.00E-01 OEPA 2.00E-01 OEPA NA NA NA NA



A96


A97


E97

VAP: IRIS chronic value adjusted by removing UF of 10 for uncertainty in extrapolation of subchronic data to levels of chronic effects.

A99


A100


E100


A101


D101

VAP: Oral RfD of 0.6 mg/kg-day updated to 0.3 mg/kg-day on 9/30/02.

A102


D102

VAP: Based upon IRIS value for Aroclor 1254.

E102

VAP: IRIS chronic value adjusted by removinf UF of 3 for subchronic to chronic

F102

VAP: Based upon IRIS value for Aroclor 1254 and removing UF of 3 for subchronic to chronic extrapolation.

A103


E103

VAP: IRIS chronic value adjusted by removing UF of 10 for the use of a subchronic study for chronic RfD derivation

A104


E104

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolation from a subchronic to chronic effect level

A105


A106


E106


A107


E107

VAP: IRIS chronic value adjusted by removing UF of 10 for extrapolation of a subchronic effect level to its chronic equivalent.

A108


A109

Trimethylbenzene, 1,2,4 - Synonyms: Pseudocumene

A110


A111


A112


I112


A114


A115


A116


D116

VAP: Updated 7/11/2005.

A117


A118


D118

VAP: IRIS provides values for water (5x 10-4 mg/kg-d) and food (1 x 10-3 mg/kg-day)

A119


D119

VAP: Previous RfDo was 1E+0 mg/kg-day, new value of 1.5 was updated on 9/3/98.

A120


G120

VAP: Value listed is for particulates. A chronic RfC for vapors from IRIS is 8E-06 mg/m3 (2.288E-06 mg/kg/d)

I120

VAP: Value listed is for particulates. A chronic RfC for vapors from IRIS is 8E-06 mg/m3.

A123


A124


A125


C125

VAP: OEPA uses oral RfD for Methyl Mercury

G125

VAP: OEPA uses the inhalation RfC of 3.0E-04 mg/cu. m for elemental mercury.

A126


G126

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 9E-05 mg/cu. m for nickel (Ni).

I126

VAP: Based on intermediate-duration (15 to 364 days) inhalation MRL of 0.0002 mg Ni/cu. m

A127


A128


D129

VAP: OEPA uses Oral RfD for Thallium sulfate, Thallium chloride, and Thallium cabonate. Oral RfD for Thallium acetate and/or Thallium nitrate is 9.0E-5 (mg/kg)/day.

E129


F129

VAP: OEPA uses Oral RfD for Thallium sulfate, Thallium chloride, and Thallium cabonate. Oral RfD for Thallium acetate and/or Thallium nitrate is 9.0E-5 (mg/kg)/day.

C130

VAP: OEPA use Oral RfD for Vanadium Pentoxide (CASRN 1314-62-1). HEAST gives a Chronic Oral RfD of 7.00E-03 for metallic Vanadium (CASRN 7440-62-2).

E130

VAP: OEPA uses subchronic Oral RfD for Vanadium Pentoxide (CASRN 1314-62-1). HEAST gives a Subchronic Oral RfD of 7.00E-03 for metallic Vanadium (CASRN 7440-62-2).

A131


D131

VAP: Updated 8/3/2005

E131


D133

VAP: Old RfDo of 2.0E-01 was updated on 12/22/03 (IRIS) to 4.0E-03.

E133

VAP: An UF was not needed to account for subchronic to chronic extrapolation because a chronic study (81 weeks) was used to derive the RfD.

H133

VAP: Based on the Medium Confidence IRIS RfC value for toluene, a DERR/VAP Recommended Toxicological Surrogate.

J133

VAP: Based on the NCEA subchronic RfC value for toluene, a DERR/VAP Recommended Toxicological Surrogate.

D134

VAP: Based on the Low Confidence IRIS value for o-chlorotoluene (2-chlorotoluene), a DERR/VAP Recommended Toxicological Surrrogate.

F134

VAP: Based on the Low Confidence IRIS value for o-chlorotoluene (2-chlorotoluene), a DERR/VAP Recommended Toxicological Surrrogate. IRIS chronic value adjusted by removing UF of 10 for use of subchronic study.

A135


D135

VAP: Based on the Low Confidence value from IRIS for acenaphthene, a DERR/VAP Recommended Toxicological Surrogate.

F135

VAP: Based on the Low Confidence value from IRIS for acenaphthene, a DERR/VAP Recommended Toxicological Surrogate.

A136


D136

VAP: Based on the low confidence value in IRIS for pyrene (June 1998), the DERR/VAP recommended toxicological surrogate.

F136

VAP: Based on the value in HEAST for pyrene (1997), the DERR/VAP recommended toxicological surrogate.

E137


A138


F138

VAP: Based on the IRIS Low confidence RfDo value for diethyl phthalate (CASRN 84-66-2), the DERR/VAP recommended as a toxicological surrogate.

D139

VAP: Based on the HEAST (07/97) chronic RfD for methyl isobutyl ketone, the DERR/VAP-recommended toxicological surrogate.

F139

VAP: Based on the HEAST (07/97) subchronic RfD for methyl isobutyl ketone, the DERR/VAP-recommended toxicological surrogate.

H139

VAP: Based on the IRIS chronic RfC for methyl isobutyl ketone, the DERR/VAP-recommended toxicological surrogate.

J139

VAP: Based on the HEAST (07/97) Alternate subchronic RfD of 8E-01 mg m-3 for methyl isobutyl ketone, the DERR/VAP recommended toxicological surrogate.

D140

VAP: Based on the Medium Confidence IRIS value for toluene, a DERR/VAP Recommended Toxicological Surrogate.

F140


H140


J140


D141

CAP: Based on the IRIS (June 1999) Low Confidence RfD for cumene (isopropyl benzene), the DERR/VAP recommended toxicological surrogate.

F141

VAP: Based on the HEAST (1997) subchronic RfDo for cumene (isopropyl benzene), the DERR/VAP recommended toxicological surrogate.

H141

VAP: Converted from the IRIS Medium Confidence (chronic) RfC of 4E-01 mg m-3 for cumene (isopropyl benzene), the DERR/VAP recommended toxicological surrogate.

I141

VAP: IRIS chronic value adjusted by removing UF of 10 for subchronic-to-chronic extrapolation

J141

VAP: Converted from the HEAST (1997) RfC of 9E-02 mg m-3 for cumene (isopropyl benzene), the DERR/VAP recommended toxicological surrogate.

A142


D142

VAP: Based on the Low Confidence value from IRIS for anthracene, the EAU Recommended Toxicological Surrogate.

F142

VAP: Based on the HEAST value for anthracene, the EAU Recommended Toxicological Surrogate.

F143

VAP: Based on Medium Confidence IRIS value for xylene, an EAU Recomended Toxicological Surrogate.

Sec-butyl benzene 135-98-8 8.00E-02 OEPA 8.00E-01 OEPA 5.00E+00 OEPA 9.23E-01 OEPATert-butyl benzene 98-06-6 8.00E-02 OEPA 8.00E-01 OEPA 5.00E+00 OEPA 9.23E-01 OEPA

HEAST - US EPA. 1997. Health Effects Assessment Summary Tables. EPA-540-R-97-036.ATSDR - http://www.atsdr.cdc.gov/toxpro2.html

IRIS - http://www.epa.gov/iris/index.htmlNCEA – Provisional values may be obtained from RAIS ( http://rais.ornl.gov/ )

http://www.atsdr.cdc.gov/toxpro2.html

http://www.epa.gov/iris/index.html

http://rais.ornl.gov/

D144


F144


H144


J144


D145


F145


H145


J145


Conversion of Inhaltion RfCs & Unit Risk Factors toCAS RfDs and Slope Factors for Inhalation from Groundwater

Number Inhalation RfD Inhalation

Source (mg/kg-day) Source

Volatile Organic CompoundsAcetone 67-64-1 3.09E+01 ATSDR 8.84E+00 NA NABenzene 71-43-2 3.00E-02 IRIS 8.58E-03 2.20E-03 IRISCarbon Disulfide 75-15-0 7.00E-01 IRIS 2.00E-01 NA NACarbon Tetrachloride 56-23-5 2.00E-03 NCEA 5.72E-04 1.50E-02 IRISChlorobenzene 108-90-7 5.00E-02 NCEA 1.43E-02 NA NAChloroethane 75-00-3 1.00E+01 IRIS 2.86E+00 NA NAChloroform 67-66-3 1.00E-01 ATSDR 2.86E-02 2.30E-02 IRISDibromochloromethane 124-48-1 NA NA NA NA NADichlorodifluoromethane 75-71-8 2.00E-01 HEAST 5.72E-02 NA NADichloroethane, 1,1 - 75-34-3 5.00E-01 HEAST 1.43E-01 1.60E-03 Cal/EPADichloroethane, 1,2 - 107-06-2 2.40E+00 ATSDR 6.86E-01 2.60E-02 IRISDichloroethene, 1,1 - 75-35-4 2.00E-01 IRIS 5.72E-02 NA

156-59-2 NA NA NA NA NA156-60-5 6.00E-02 NCEA 1.72E-02 NA NA

Dichloropropane, 1,2 - 78-87-5 4.00E-03 IRIS 1.14E-03 1.00E-02 Cal/EPADichloropropene, 1,3 - 542-75-6 2.00E-02 IRIS 5.72E-03 4.00E-03 IRISDioxane, 1,4 - 123-91-1 3.60E+00 ATSDR 1.03E+00 7.70E-03 Cal/EPAEthyl Ether 60-29-7 NA NA NA NA NAEthylbenzene 100-41-4 1.00E+00 IRIS 2.86E-01 NA NAFormaldehyde 50-00-0 1.00E-02 ATSDR 2.86E-03 1.30E-02 IRISFormic acid 64-18-6 3.00E-03 NCEA 8.58E-04 NA NA

110-54-3 7.00E-01 IRIS 2.00E-01 NA NAIsobutyl Alcohol 78-83-1 NA NA NA NA NAMethanol 67-56-1 4.00E+00 Cal/EPA 1.14E+00 NA NAMethyl Ethyl Ketone (MEK) 78-93-3 5.00E+00 IRIS 1.43E+00 NA NAMethyl Isobutyl Ketone (MIBK) 108-10-1 3.00E+00 IRIS 8.58E-01 NA IRIS

1634-04-4 3.00E+00 IRIS 8.58E-01 2.60E-04 Cal/EPAMethylene Chloride 75-09-2 1.00E+00 ATSDR 2.86E-01 4.70E-04 IRISStyrene 100-42-5 1.00E+00 IRIS 2.86E-01 NA NATetrachloroethane , 1,1,1,2 - 630-20-6 NA NA NA 7.40E-03 IRISTetrachloroethane, 1,1,2,2 - 79-34-5 NA NA NA 5.80E-02 IRISTetrachloroethene 127-18-4 2.71E-01 ATSDR 7.75E-02 5.90E-03 Cal/EPAToluene 108-88-3 5.00E+00 IRIS 1.43E+00 NA NATrichloroethane, 1,1,1 - 71-55-6 2.20E+00 NCEA 6.29E-01 NA NATrichloroethane, 1,1,2 - 79-00-5 NA NA NA 1.60E-02 IRISTrichloroethene 79-01-6 6.00E-01 Cal/EPA 1.72E-01 2.00E-03 Cal/EPATrichlorofluoromethane 75-69-4 7.00E-01 HEAST 2.00E-01 NA NATrichloropropane, 1,2,3 - 96-18-4 NA NA NA NA NAVinyl Chloride 75-01-4 1.00E-01 IRIS 2.86E-02 8.80E-03 IRISXylenes, Total 1330-20-7 1.00E-01 IRIS 2.86E-02 NA NA

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9 NA NA NA NA NAAcetophenone 98-86-2 NA NA NA NA NAAcrylonitrile 107-13-1 2.00E-03 IRIS 5.72E-04 6.80E-02 IRISAniline 62-53-3 1.00E-03 IRIS 2.86E-04 1.60E-03 Cal/EPA

Chemical (Synonyms in comments)

(mg/m3) (mg/m3)-1

IRISDichloroethene, cis - 1,2 Dichloroethene, trans - 1,2 -

Hexane, n -


http://www.epa.gov/iris/subst/0039.htm#II.

B2


A6


C6

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 13 ppm. MRL converted to RfC of 30.9 mg/ cu. m

A7


D7

VAP: Inhalation RfD was updated (IRIS) from 2.57E-03 mg/kg/d to 3.0E-2 mg/m3 (8.58E-3 mg/kg/d) on 4/17/03.

F7

VAP: IRIS has (AURF) range of 2.2×10-6 to 7.8×10-6 µg/m3. The VAP currently uses and has taken the low end AURF (2.2E-06 µg/m3) and derived SFinh by multiplying by 3.5E+03 (day kg µg/m3 mg-1), resulting a Sfinh 7.7E-03 mg/kg/d. IRIS states that any value within the range will have equal scientific plausibility.

A8


A9


A10


A11


A12


C12

VAP: Based on chronic-duration ( 365 days or greater) inhalation MRL of 0.02 ppm. MRL converted to RfC of 0.1 mg/ cu. m

A13


A14


A15


A16


C16


A17


C17

VAP: NEW IRIS RfC of 2E-1 mg/m3 on 8/13/02

F17

VAP: Old inhalation SF of 1.75E-01 mg/kg/d was withdrawn by IRIS on 8/13/02 due to lack of carcinogenic evidence.

A18


A19


A20


A21


A22


C22


A23


A24


A25


C25


A26


A27


D27

VAP: RfC updated from 2.0 E-02 mg/cu. m to 7.0E-01 mg/cu. m on 12/23/2005

A28


A29


A30


D30

VAP: Old RfC of 0.286 (1 mg/m3) was updated (IRIS) on 9/29/03 to 5 mg/m3 (1.43 mg/kg/d).

A31


D31

VAP: Old RfC of 2.29E-02 was updated (IRIS) to 3 mg/m3 (.858 mg/kg/d) on 4/25/03.

G31

VAP: Data inadequate for an assessment of human carcinogenic potential as per IRIS on 4/25/03.

A32


A33


C33


A34


A35


A36


A37


C37


G37

VAP: RAIS references Region 9 and CA EPA.

A38


A39


A40


A41


C41

VAP: Based on California EPA Inhalatin Reference Exposure Level of 600 ug/ cu. M (10 ppb).

A42


A43


A44


A45


C45

VAP: Old RfC of 0.123 (ATSDR) was updated to 0.1 mgm3 (0.0286 mg/kg/day) from IRIS on 2/21/03.

A47


A48


A49


A50


Anthracene 120-12-7 NA NA NA NA NABenzidine 92-87-5 NA NA NA 6.70E+01 IRISBenzo(a)anthracene 56-55-3 NA NA NA 8.80E-02 NCEABenzo(a)pyrene 50-32-8 NA NA NA 8.80E-01 NCEABenzo(b)fluoranthene 205-99-2 NA NA NA 8.80E-02 NCEABenzo(k)fluoranthene 207-08-9 NA NA NA 8.80E-03 NCEABis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 NA NA NA 2.40E-03 Cal/EPAButyl Benzyl Phthalate 85-68-7 NA NA NA NA NACarbazole 86-74-8 NA NA NA NA NAChlordane 57-74-9 7.00E-04 IRIS 2.00E-04 1.00E-01 IRISChrysene 218-01-9 NA NA NA 8.80E-04 NCEADibenz(a,h)anthracene 53-70-3 NA NA NA 8.80E-01 NCEADichlorobenzene, 1,2 - (o) 95-50-1 2.00E-01 HEAST 5.72E-02 NA NADichlorobenzene, 1,4 - (p) 106-46-7 8.00E-01 IRIS 2.29E-01 1.10E-02 Cal/EPADichlorobenzidine, 3,3 - 91-94-1 NA NA NA 3.40E-01 Cal/EPADichlorodiphenyldichloroethane (DDD) 72-54-8 NA NA NA 6.90E-02 Cal/EPADichlorodiphenyldichloroethene (DDE) 72-55-9 NA NA NA 9.70E-02 Cal/EPADichlorodiphenyltrichloroethane (DDT) 50-29-3 NA NA NA 9.70E-02 IRISDichlorophenoxyacetic acid, 2,4 - 94-75-7 NA NA NA NA NADiethyl Phthalate 84-66-2 NA NA NA NA NADimethylphenol, 2,4 - 105-67-9 NA NA NA NA NADi-n-butyl Phthalate 84-74-2 NA NA NA NA NA

99-65-0 NA NA NA NA NADinitrobenzene, 1,2 - 528-29-0 NA NA NA NA NADinitrotoluene, 2,4 - 121-14-2 NA NA NA NA NADinitrotoluene, 2,6 - 606-20-2 NA NA NA NA NAEndrin 72-20-8 NA NA NA NA NAEthylene Glycol 107-21-1 4.00E+00 Cal/EPA 1.14E+00 NA NAFluoranthene 206-44-0 NA NA NA NA NAFluorene 86-73-7 NA NA NA NA NAHeptachlor 76-44-8 NA NA NA 1.30E+00 IRISHeptachlor Epoxide 1024-57-3 NA NA NA 2.60E+00 IRISHexachloro- 1,3 - Butadiene 87-68-3 NA NA NA 2.20E-02 IRISHexachlorobenzene 118-74-1 NA NA NA 4.60E-01 IRISHexachloroethane 67-72-1 NA NA NA 4.00E-03 IRISIndeno(1,2,3-c,d)pyrene 193-39-5 NA NA NA 8.80E-02 NCEAIsophorone 78-59-1 2.00E+00 Cal/EPA 5.72E-01 NA NAIsopropylbenzene (Cumene) 98-82-8 4.00E-01 IRIS 1.14E-01 NA NALindane 58-89-9 NA NA NA 3.10E-01 Cal/EPAm-cresol 108-39-4 NA NA NA NA NAMethoxychlor 72-43-5 NA NA NA NA NAMethylnaphthalene, 1 - 90-12-0 NA NA NA NA NANaphthalene 91-20-3 3.00E-03 IRIS 8.58E-04 3.40E-02 Cal/EPANitrobenzene 98-95-3 2.00E-03 HEAST 5.72E-04 NA NA

86-30-6 NA NA NA 2.60E-03 Cal/EPAo-cresol 95-48-7 NA NA NA NA NA

117-84-0 NA NA NA NA NAp-cresol 106-44-5 NA NA NA NA NAPentachlorophenol 87-86-5 NA NA NA 4.60E-03 Cal/EPAPhenol 108-95-2 2.00E-01 Cal/EPA 5.72E-02 NA NA




A51


A52


A53


F53

VAP: Value is extrapolated from NCEA value for Benzo(a)pyrene adjusted with USEPA Region 4 derived Toxicity Equivalency Factor (0.1). TEFs are based on the relative potency of each compound relative to that of benzo(a)pyrene (http://www.epa.gov/Region4/waste/ots/healtbul.htm).

A54


G54

VAP: RAIS states provisional toxicity value developed by NCEA, and also references Region 4 Human Health Risk Assessment Bulletins, Supplement to RAGS

A55


F55


A56


F56


A57


A58


A60


A61


F61


A62


F62


A63


A64


A65


A66


A67


A68


A69


A70


A71


A72


A73


A74


A75


A76


A77


A78


A79


A80


A81


A82


A83


A84


A85


A86


F86


A87


A88


A89


A90


A91


A93


A94


A95


A96


A98


A99


A100


Polychlorinated Biphenyls 1336-36-3 NA NA NA 1.00E-01 IRISPyrene 129-00-0 NA NA NA NA NAPyridine 110-86-1 NA NA NA NA NASilvex 93-72-1 NA NA NA NA NAToxaphene 8001-35-2 NA NA NA 3.20E-01 IRISTrichlorophenol, 2,4,5 - 95-95-4 NA NA NA NA NATrichlorophenol, 2,4,6 - 88-06-2 NA NA NA 3.100E-03 IRISTrimethylbenzene, 1,2,4 - 95-63-6 6.00E-03 NCEA 1.72E-03 NA NATrimethylbenzene, 1,3,5 108-67-8 6.00E-03 NCEA 1.72E-03 NA NATrinitrobenzene, 1,3,5 - (s) 99-35-4 NA NA NA NA NAVinyl Acetate 108-05-4 2.00E-01 IRIS 5.72E-02 NA NA

Inorganic AnalytesAntimony 7440-36-0 NA NA NA NA NAArsenic, Inorganic 7440-38-2 NA NA NA 4.30E+00 IRISBarium and Compounds 7440-39-3 5.00E-04 HEAST 1.43E-04 NA NABeryllium and Compounds 7440-41-7 2.00E-05 IRIS 5.72E-06 2.40E+00 IRISCadmium 7440-43-9 NA NA NA 1.80E+00 IRISChromium (III) (Insoluble Salts) 16065-83-1 NA NA NA NA NAChromium (VI) 18540-29-9 1.00E-04 IRIS 2.86E-05 1.20E+01 IRISChromium (Total) NA NA NA NA NA NACobalt 7440-48-4 2.00E-05 NCEA 5.72E-06 2.80E+00 NCEACyanide, Free 57-12-5 NA NA NA NA NAFluorine (soluble fluoride) 7782-41-4 NA NA NA NA NAMercury 7439-97-6 3.00E-04 IRIS 8.58E-05 NA NANickel (Soluble Salts) Various 9.00E-05 ATSDR 2.57E-05 NA NASelenium and Compounds 7782-49-2 NA NA NA NA NASilver 7440-22-4 NA NA NA NA NAThallium 7440-28-0 NA NA NA NA NAVanadium 7440-62-2 NA NA NA NA NAZinc and Compounds 7440-66-6 NA NA NA NA NA

Supplemental Criteria2-methylnaphthalene 91-57-6 5.00E+00 OEPA 1.43E+00 NA NA4-chlorotoluene 106-43-4 NA NA NA NA NAAcenaphthylene 208-96-8 NA NA NA NA NABenzo(g,h,i)perylene 191-24-2 NA NA NA NA NACopper 7440-50-8 NA NA NA NA NADimethyl phthalate 131-11-3 NA NA NA NA NAMethyl butyl ketone 591-78-6 3.00E+00 OEPA 8.58E-01 NA NAn-butyl benzene 104-51-8 5.00E+00 OEPA 1.43E+00 NA NAn-propyl benzene 103-65-1 4.00E-01 OEPA 1.14E-01 NA NAPhenanthrene 85-01-8 NA NA NA NA NAp-isopropyltoluene (Cymene) 99-87-6 NA NA NA NA NASec-butyl benzene 135-98-8 5.00E+00 OEPA 1.43E+00 NA NATert-butyl benzene 98-06-6 5.00E+00 OEPA 1.43E+00 NA NA

A101


A102


A103


A104


A105


A106


A107


A108


A109


A110


A111


A113


A114


A115


A116


A117


A118


A119


C119

VAP: Value listed is for particulates. A chronic RfC for vapors from IRIS is 8E-06 mg/m3 (2.288E-06 mg/kg/d)

A122


A123


A124


C124

VAP: OEPA uses the inhalation RfC of 3.0E-04 mg/cu. m for elemental mercury.

A125


C125

VAP: Based on chronic-duration (365 days or greater) inhalation MRL of 9E-05 mg/cu. m for nickel (Ni).

A126


A127


A130


D132


A134


A135


A137


D138

VAP: Based on the IRIS chronic RfC for methyl isobutyl ketone, the DERR/VAP-recommended toxicological surrogate.

D139


D140

VAP: Converted from the IRIS Medium Confidence (chronic) RfC of 4E-01 mg m-3 for cumene (isopropyl benzene), the DERR/VAP recommended toxicological surrogate.

A141


D143


D144


Conversion of Inhaltion RfCs & Unit Risk Factors toRfDs and Slope Factors for Inhalation from Groundwater

Slope Factor

NA7.70E-03

NA5.25E-02

NANA

8.05E-02NANA

5.60E-039.10E-02

NANANA

3.50E-021.40E-022.70E-02

NANA

4.55E-02NANANANANANA

9.10E-041.65E-03

NA2.59E-022.03E-012.06E-02

NANA

5.60E-027.00E-03

NANA

3.08E-02NA

NANA

2.38E-015.60E-03

(mg/kg-day)-1

NA2.35E+023.08E-013.08E+003.08E-013.08E-028.40E-03

NANA

3.50E-013.08E-033.08E+00

NA3.85E-021.19E+002.42E-013.40E-013.40E-01

NANANANANANANANANANANANA

4.55E+009.10E+007.70E-021.61E+001.40E-023.08E-01

NANA

1.09E+00NANANA

1.19E-01NA

9.10E-03NANANA

1.61E-02NA

3.50E-01NANANA

1.12E+00NA

1.09E-02NANANANA

NA1.50E+01

NA8.40E+006.30E+00

NA4.20E+01

NA9.80E+00

NANANANANANANANANA

NANANANANANANANANANANANANA

OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)ORAL RfD TOXICITY METADATA FOR CHEMICALS OF CONCERN

Chemical CAS # RfD Basis RfD Confidence Level RfD Critical Effect RfD Modifying Factor RfD Study Reference RfD Study Date Type of Study (Route) RfD Study Species RfD Target Organ Chronic RfD Uncertainty Factor Sunbchrinic RfD UF

Volatile Organic CompoundsAcetone 67-64-1 NOAEL medium nephropathy 1 Dietz et al and NTP 1991 subchronic; drinking water rat kidney 1000Benzene 71-43-2 BMDL medium decreased lymphocyte count 1 Rothman et. al. 1996 occupational inhalation human blood 300Carbon Disulfide 75-15-0 NOEL medium fetal toxicity/malformations 1 Hardin et al. 1981 Inhalation Teratogenic Study rabbit fetus 100 100Carbon Tetrachloride 56-23-5 NOAEL/LOAEL medium lesions; substantially elevated sorbitol dehydrogenase, mild centrilobular vacuolization 1 Bruckner et al. 1986 gavage rat liver 1000 100Chlorobenzene 108-90-7 NOAEL/LOAEL medium histopathologic changes 1 Monsato Co., Knapp et al. 1971 capsule dog liver 1000Chloroethane 75-00-3Chloroform 67-66-3 LOAEL/BMD medium fatty cyst formation, elevated SGPT 1 Heywood et al. 1979 chronic oral bioassay dog liver 1000 100Dibromochloromethane 124-48-1 NOEL/LOAEL medium hepatic lesions 1 NTP 1985 subchronic gavage rat liver 1000 100Dichlorodifluoromethane 75-71-8 NOAEL/LOAEL medium reduced weight 1 Sherman 1974 diet rat whole body 100 100Dichloroethane, 1,1 - 75-34-3 NOAEL low none observed 1 Muralidhara et al. 2001 rat kidney 3000 300Dichloroethane, 1,2 - 107-06-2 LOAEL medium increased kidney weight 1 NTP 1991 13-week gavage, water studies rat kidney 3000 300Dichloroethene, 1,1 - 75-35-4 LOAEL medium fatty change 1 Quast et al. 1983 drinking water rat liver 100 1000

156-59-2 NOAEL low decreased hematocrit 1 McCauley et al. 1995 rat blood 3000156-60-5 NOAEL/LOAEL low increased serum alkaline phosphatase in males 1 Barnes et al. 1985 drinking water mouse 1000

Dichloropropane, 1,2 - 78-87-5 LOAEL necrosis; slight anemia NTP; Bruckner et al. 1986; 1989 gavage mouse; rat liver; blood 1000 1000Dichloropropene, 1,3 - 542-75-6 BMDL/BMD high chronic irritation (forestomach hyperplasia), decreased body weight, increased organ weight 1 Stott et al. 1995 chronic feeding study rat stomach, whole body, organs 100Dioxane, 1,4 - 123-91-1 NOAEL heptacellular degeneration and necrosis; swelling in central area Kociba et al.; JBRC 1974; 1998 water rat liver 100 100Ethyl Ether 60-29-7 NOAEL/LOAEL low depressed body weight 1 U.S. EPA 1986 subchronic, gavage rat whole body 3000Ethylbenzene 100-41-4 NOEL/LOAEL low toxicity 1 Wolf et al. 1956 gavage, bioassay rat liver, kidney 1000

Formaldehyde 50-00-0 NOALE/LOAEL medium 1 Til et al.; Rusch et al. 1989; 1983 drinking water, bioassay rat whole body, gastro-intestinal tract 100 30Formic acid 64-18-6 NOAEL Decreased growth 1 U.S. EPA 1990 water rat whole body 100 100

110-54-3 LOAEL unknown Neuropathy, atrophy 1 U.S. EPA 1989 rat nervous system, testis 10000 1000Isobutyl Alcohol 78-83-1 NOEL/LOAEL low hypoactivity and ataxia 1 U.S. EPA 1986 subchronic; gavage rat nervous system 1000Methanol 67-56-1 NOEL/LOAEL medium increased SAP and SGPT, decreased brain weight 1 U.S. EPA 1986 subchronic, gavage rat blood, brain 1000Methyl Ethyl Ketone (MEK) 78-93-3 NOAEL/LOAEL low decreased fetal birth weight 1 Cox et al. 1975 multigenerational reproductive, drinking water rat fetus 1000 1000Methyl Isobutyl Ketone (MIBK) 108-10-1 NOAEL Lethargy, increased absolute and relative organ weights, increased urinary protein levels 1 U.S. EPA 1993 subchronic, gavage rat whole body, liver, kidney 3000 300

1634-04-4 LOAEL decreased BUN values Robinson et al. 1990 gavage in oil rat liver 300Methylene Chloride 75-09-2 NOAEL/LOAEL medium toxicity 1 National Coffee Association 1982 rat liver 100Styrene 100-42-5 NOAEL/LOAEL medium red blood cell and liver effects 1 Quast et al. 1979 subchronic, gavage dog blood, liver 1000Tetrachloroethane , 1,1,1,2 - 630-20-6 LOAEL low mineralization of kidneys in males, hepatic clear cell change, lesions 1 NTP 1983 gavage, chronic rat liver, kidney 3000 3000Tetrachloroethane, 1,1,2,2 - 79-34-5 NOAEL; BMD low hepatocellular vacuolization & increases in absolute & relative weight; minimal hepatocyte necrosis 1 Microbiological Associates; NTP 1994; 2004 feed rat liver 300 100Tetrachloroethene 127-18-4 NOAEL/LOAEL medium hepatotoxicity, weight gain 1 Buben and O'Flaherty 1985 gavage, subchronic mouse/rat liver; whole body 1000Toluene 108-88-3 BMDL medium increased weight 1 NTP 1990 gavage, subchronic rat kidney 3000Trichloroethane, 1,1,1 - 71-55-6 NOAEL medium to low toxicity 1 Quast et al. ; NTP 1978; 2000 feed rat; mouse liver 90 100Trichloroethane, 1,1,2 - 79-00-5 NOAEL/LOAEL medium clinical serum chemistry 1 White et al., Sanders et al. 1985 subchronic, drinking water mouse blood 1000Trichloroethene 79-01-6 BMD nephropathy Cal/EPA 1999 oral chronic study rats kidney 100Trichlorofluoromethane 75-69-4 LOAEL medium survival and histopathology, increased mortality 1 NCI 1978 cancer bioassay rat, mouse whole body 1000 1000Trichloropropane, 1,2,3 - 96-18-4 NOAEL/LOAEL low alterations in clinical chemistry and reduction in red cell mass 1 NTP 1983 subchronic, gavage rat whole body, liver, kidney, erythrocytes, blood 1000Vinyl Chloride 75-01-4 NOAEL/LOAEL medium cell polymorphism 1 Til et al 1983, 1991 chronic feeding study rat liver 30Xylenes, Total 1330-20-7 NOAEL medium decreased body weight, increased mortality 1 NTP 1986 chronic gavage exposure rat whole body 1000

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9 NOAEL/LOAEL low hepatotoxicity 1 U.S. EPA 1989 gavage mouse liver 3000Acetophenone 98-86-2 NOAEL low general toxicity 1 Hagen 1967 diet rat 3000Acrylonitrile 107-13-1 NOAEL decreased red blood cells; decreased sperm count, tubular degeneration 1 Biodinamics; Tandon 1980; 1988 rat; mouse blood; reproductive system 100 1000Aniline 62-53-3 LOAEL medium effects 1 CIIT 1982 rat blood and spleen 1000Anthracene 120-12-7 NOEL low none observed 1 U.S. EPA 1989 gavage mouse 3000Benzidine 92-87-5 LOAEL medium cell vacuolization, cell alterations 1 Littlefield et al. 1983 bioassay, drinking water mouse brain, liver 1000 1000Benzo(a)anthracene 56-55-3Benzo(a)pyrene 50-32-8Benzo(b)fluoranthene 205-99-2Benzo(k)fluoranthene 207-08-9Bis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 LOAEL medium increased relative weight 1 Carpenter et al. 1953 subchronic to chronic, diet guinea pig liver 1000Butyl Benzyl Phthalate 85-68-7 NOAEL/LOAEL low significantly increased weight ratios 1 NTP 1985 diet rat liver 1000 100Carbazole 86-74-8Chlordane 57-74-9 NOAEL/LOAEL medium necrosis, hypertrophy 1 Khasawinah and Grutsch 1989 diet mouse liver 300 1000Chrysene 218-01-9Dibenz(a,h)anthracene 53-70-3Dichlorobenzene, 1,2 - (o) 95-50-1 NOAEL low none observed 1 NTP 1985 gavage rat 1000Dichlorobenzene, 1,4 - (p) 106-46-7 BMD increases in serum alkaline phosphatase and liver weight, heptacellular hypertrophy Naylor & Strout 1996 capsule dog liver 100Dichlorobenzidine, 3,3 - 91-94-1Dichlorodiphenyldichloroethane (DDD) 72-54-8 LOAEL low reduced spleen weight, humoral immune responses and cell-mediated 1 Banerjee et al. 1996 rat spleen 10000Dichlorodiphenyldichloroethene (DDE) 72-55-9Dichlorodiphenyltrichloroethane (DDT) 50-29-3 NOEL/LOAEL medium lesions 1 Laug et al. 1950 diet rat liver 100 100Dichlorophenoxyacetic acid, 2,4 - 94-75-7 NOAEL/LOAEL medium Hematologic, hepatic and renal toxicity 1 Dow Chemical Co. 1983 bioassay, diet rat blood, liver, kidney 100 100Diethyl Phthalate 84-66-2 NOAEL/LOAEL low decreased growth weight, food consumption, altered organ weights 1 Brown et al. 1978 subchronic oral feeding study rat whole body, organs 1000Dimethylphenol, 2,4 - 105-67-9 NOAEL/LOAEL low lethargy, prostration, ataxia, hematological changes 1 U.S. EPA 1989 subchronic gavage mouse nervous system, blood 3000Di-n-butyl Phthalate 84-74-2 NOAEL/LOAEL low increased mortality 1 Smith 1953 oral rat whole body 1000

99-65-0 NOAEL/LOAEL low Increased spleen weight 1 Cody et al. 1981 subchronic, drinking water rat spleen 3000Dinitrobenzene, 1,2 - 528-29-0 NOAEL low increased weight 1 Cody et al. 1981 rat spleen 3000Dinitrotoluene, 2,4 - 121-14-2 NOAEL/LOAEL high neurotoxicity, heinz bodies, and biliary tract hyperplasia 1 Ellis et al. 1985 gelatin capsule dog central nervous system, erythrocytes, biliary tract 100 100Dinitrotoluene, 2,6 - 606-20-2 NOAEL medium Neurological, hematological, and liver histopathology 1 Lee et al. 1976 dog whole body 3000Endrin 72-20-8 NOEL/LOAEL medium mild histological lesions, occasional convulsions; neurotoxic effects 1 Velsicol Chemical; Treon et al. 1969; 1955 diet, chronic oral bioassay dog liver, central nervous system 100 100Ethylene Glycol 107-21-1 NOAEL/LOAEL high toxicity, fetotoxicity 1 DePass 1986 diet, chronic rat kidney, fetus 100 100Fluoranthene 206-44-0 NOAEL/LOAEL low nephropathy, increased weight, hematological alterations and clinical effects 1 U.S. EPA; ATSDR 1988 subchronic, gavage mouse kidney, liver, blood 3000 300Fluorene 86-73-7 NOAEL/LOAEL low decreased RBC, packed cell volume, hemoglobin, decreased erythrocytes 1 U.S. EPA 1989 subchronic, gavage mouse blood, erythrocytes 3000Heptachlor 76-44-8 NOEL/LEL low weight increases; developmental immunological and neurological effects 1 Velsicol Chemical; Smialowicz et al. 1955; 2001 rat liver; development 300 300Heptachlor Epoxide 1024-57-3 LEL low increased relative weight (liver-to body ratio) 1 Dow Chemical Co. 1958 diet dog liver 1000 1000Hexachloro- 1,3 - Butadiene 87-68-3 NOAEL/LOAEL medium effects (induced carboxylesterase activity); presence of kidney damage (tubular degeneration) 1 Arnold et al.; NTP 1985; 1991 chronic feeding study rat; mice liver; kidney 100 1000Hexachlorobenzene 118-74-1 LOAEL Regeneration 1 U.S. EPA 1993 diet mouse kidney (renal tubules) 1000Hexachloroethane 67-72-1 NOAEL/LOAEL medium atrophy and degeneration of renal tubules 1 Gorzinki et al. 1985 subchronic dietary rat kidney 1000Indeno(1,2,3-c,d)pyrene 193-39-5Isophorone 78-59-1 NOEL low none observed 1 Nor-Am Agricultural Products, Inc. 1972 capsule dog kidney 1000Isopropylbenzene (Cumene) 98-82-8 NOAEL/LOAEL low increased average weight in females 1 Wolf et al. 1956 gavage rat kidney 1000Lindane 58-89-9 NOAEL/LOAEL medium toxicity 1 Zoecon Corp. 1983 diet, subchronic bioassay rat liver, kidney 1000m-cresol 108-39-4 NOAEL/LOAEL medium decreased weight and neurotoxicity 1 U.S. EPA 1987 subchronic neurotoxicity, gavage rat whole body, nervous system 1000Methoxychlor 72-43-5 NOEL/LEL low excessive loss of litters; accelerated onset of puberty (precocious vaginal opening) 1 Kincaid Enterprises; Chapin et al. 1986; 1997 rabbit; rat fetus, reproduction; reproductive 1000 1000Methylnaphthalene, 1 - 90-12-0 LOAEL pulmonary alveolar proteinosis Murata et al. 1993 dietary mice respiratory system 1000Naphthalene 91-20-3 NOAEL/LOAEL low decreased mean terminal body weights in males 1 BCL 1980 subchronic, gavage rat whole body 3000Nitrobenzene 98-95-3 LOAEL low hematological effects; adrenal, renal, and hepatic lesions 1 CIIT 1984 suchronic inhalation rat/mouse blood, adrenal glands, kidney, liver 10000

86-30-6 LOAEL low undescribed corneal opacity 1 NCI 1979 rat eye 3000o-cresol 95-48-7 NOAEL/LOAEL medium decreased weight and neurotoxicity 1 U.S. EPA 1987 subchronic neurotoxicity, gavage rat whole body, nervous system 1000

117-84-0 NOAEL medium hepatic effects 1 Poon et al. 1997 rat liver 1000p-cresol 106-44-5 NOAEL hypoactivity, respiratory distress, maternal death 1 U.S. EPA 1993 gavage rabbit central nervous system, respiratory system, whole body 1000 1000Pentachlorophenol 87-86-5 NOAEL/LOAEL medium pathology; increased severity of cystic uterine glands, decreased mating, decreased birth rate 1 Schwetz et al.; Beard et al. 1978; 1997 chronic, gavage; diet rat; mink liver, kidney; reproductive 100 1000Phenol 108-95-2 BMDL medium/high decreased maternal weight gain 1 Argus Research Laboratories 1997 developmental, gavage rat fetus 300 100Polychlorinated Biphenyls 1336-36-3 LOAEL medium Ocular exudate, inflamed Meibomian glands, distorted growth of nails; decreased antibody response to erythrocytes 1 Arnold et al. 1994 gelatin capsule, clinical, immunological monkey 300Pyrene 129-00-0 NOAEL/LOAEL low renal tubular pathology, decreased kidney weights 1 U.S. EPA 1989 gavage, subchronic oral bioassay mouse kidney 3000Pyridine 110-86-1 NOAEL/LOAEL medium increased weight 1 U.S. EPA 1986 gavage, subchronic rat liver 1000


reduced weight gain, histopathology, lesions; clinical signs of nasopharyngeal irritation and lesions in the nasal epithelium

Hexane, n -



diet; in utero

teratology study, gavage; in utero



A5


C5

NOAEL: 900 mg/kg-day LOAEL: 1700 mg/kg-day

G5

IRIS Oral RfD Principal Studies Dietz, DD; Leininger, JR; Rauckman, EJ; et al. (1991) Toxicity studies of acetone administered in the drinking water of rodents. Fund. Appl. Toxicol. 17:347-360. NTP (National Toxicology Program). (1991) Toxicity studies of acetone (CAS No. 67-64-1) in F344/N rats and B6C3F1 mice (drinking water studies). NTP, Research Triangle Park, NC. NTP TOX 3, NIH Publication No. 91-3122.

L5

The following UFs are applied to the effect level: 10 for consideration of intraspecies variation (UFH; human variability), 3 (101/2) for extrapolation for interspecies differences (UFA; animal to human), 3 to account for extrapolation from subchronic studies (UFs; subchronic to chronic), and 10 to account for a deficient database (UFD). The total UF = 10 × 101/2 × 101/2 × 10 = 1000.

A6


C6

BMDL = 1.2 mg/kg/day The RfD is based on route-to-route extrapolation of the results of benchmark dose (BMD) modeling of the absolute lymphocyte count (ALC) data from the occupational epidemiologic study by Rothman et al. (1996), in which workers were exposed to benzene by inhalation (IRIS).

G6

IRIS Oral RfD Principal Study Rothman, N., G.L. Li, M. Dosemeci, W.E. Bechtold, G.E. Marti, Y.Z. Wang, M. Linet, L.Q. Xi, W. Lu, M.T. Smith, N. Titenko-Holland, L.P. Zhang, W. Blot, S.N. Yin, and R.B. Hayes. 1996. Hematotoxicity among Chinese workers heavily exposed to benzene. Am. J. Ind. Med. 29: 236-246. Supporting Study- A comparison analysis based on BMD modeling of data from the National Toxicology Program's (NTP's) experimental animal gavage study (NTP, 1986) was also conducted. In addition, comparison analyses using the lowest-observed-adverse-effect levels (LOAELs) from the Rothman et al. (1996) and NTP (1986) studies were performed (IRIS). NTP (National Toxicology Program). 1986. Toxicology and Carcinogenesis Studies of Benzene (CAS No. 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, Research Triangle Park, NC.

L6

A factor of 3 will be used in this analysis, based on the professional judgement that, although the BMD corresponds to an adverse effect level at the low end of the observable range, the endpoint is not very serious in and of itself. A factor of 10 was used for intraspecies differences in response (human variability). A value of 3 for subchronic-to-chronic extrapolation. A UF of 3 was chosen to account for database deficiencies because no two-generation reproductive and developmental toxicity studies for benzene are available. Therefore, an overall UF of 3 x 10 x 3 x 3 = 300 is used to calculate the chronic oral RfD.

A7


C7

NOEL: 20 ppm (62.3 mg/cu.m) converted to 11.0 mg/kg/day

G7

IRIS Oral RfD Principal Study Hardin, B.D., G.P. Bond, M.R. Sikor, F.D. Andrew, R.P. Beliles and R.W. Niemeir. 1981. Testing of selected work place chemicals for teratogenic potential. Scand. J. Work Environ. Health. 7(Suppl. 4): 66-75. HEAST reference #010259 Hardin, B.D., G.P. Bond, M.R. Sikor, F.D. Andrew, R.P. Beliles and R.W. Niemeir. 1981. Testing of selected work place chemicals for teratogenic potential. Scand. J. Work Environ. Health. 7(Suppl. 4): 66-75. US EPA. 1985. RfD/RfC Work Group.

L7

The uncertainty factor of 100 includes 10 for interspecies and 10 for intraspecies variability to the toxicity of this chemical in lieu of specific data.

A8


C8

NOAEL: 1 mg/kg/day (converted to 0.71 mg/kg/day) LOAEL: 10 mg/kg/day (converted to 7.1 mg/kg/day)

G8

IRIS Oral RfD Principal Study Bruckner, J.V., W.F. MacKenzie, S. Muralidhara, R. Luthra, G.M. Kyle and D. Acosta. 1986. Oral toxicity of carbon tetrachloride: Acute, subacute and subchronic studies in rats. Fund. Appl. Toxicol. 6(1): 16-34. ATSDR Reference Bruckner JV, MacKenzie WF, Muralidhara S, et al. 1986. Oral toxicity of carbon tetrachloride: Acute,subacute and subchronic studies in rats. Fundam Appl Toxicol 6:16-34.

M8

10 for extrapolation from animals to humans and 10 for human variability

A9


C9

NOAEL: 27.25 mg/kg/day (adjusted dose: 19 mg/kg/day) LOAEL: 54.5 mg/kg/day

G9

IRIS Oral RfD Principal Studies Monsanto Company. 1967a. 13-week oral administration - dogs. Monchlorobenzene. Final report. Prepared by Hazelton Laboratories, Project No. 241-105, February 24. Knapp, W.K., W.M. Busey and W. Kundzins. 1971. Subacute oral toxicity of monochlorobenzene in dogs and rats. Toxicol. Appl. Pharmacol. 19: 393 (Abstract).

L9

The UF of 1000 allows for uncertainty in the extrapolation of dose levels from laboratory animals to humans (10A), uncertainty in the threshold for sensitive humans (10H), and uncertainty in the effect of duration when extrapolating from subchronic to chronic exposure (10S).

A10


A11


C11

LOAEL: 15 mg/kg/day (converted to 12.9 mg/kg/day) BMDL10 : 1.2 mg/kg/day (converted to 1.0 mg/kg/day)

G11

IRIS Oral RfD Principal Study Heywood, R; Sortwell, RJ; Noel, PRB; et al. (1979) Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851. ATSDR Reference Heywood R, Sortwell RJ, Noel PRB, et al. 1979. Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851.

L11

In the NOAEL/LOAEL approach, an additional factor of 10 was used to account for extrapolation from a LOAEL to a NOAEL (total UF = 1,000). No additional factors were required to account for extrapolation from short term to long term (the study duration was 7.5 years) or to account for limitations in the database. UF = 100 (for BMD) In the benchmark dose approach, an uncertainty factor (UF) of 10 was used to account for interspecies extrapolation, and a UF of 10 was used to protect sensitive subpopulations.

M11


A12


C12

NOEL: 30 mg/kg/day (converted to 21.4 mg/kg/day) LOAEL: 60 mg/kg/day (converted to 42.9 mg/kg/day)

G12

IRIS Oral RfD Principal Study NTP (National Toxicology Program). 1985. Toxicology and Carcinogenesis Studies of Chlorodibromomethane in F344/N Rats and B6C3F1 mice (gavage studies). NTP TR282.

L12

Factors of 10 each were employed for use of a subchronic assay, for extrapolation from animal data, and for protection of sensitive human subpopulations.

A13


C13

NOAEL: 300 ppm (converted to 15 mg/kg/day) LOAEL: 3000 ppm (converted to 150 mg/kg/day)

G13

IRIS Oral RfD Principal Study Sherman, H. 1974. Long-term feeding studies in rats and dogs with dichlorodifluoromethane (Freon 12 Food Freezant). Haskell Laboratory for Toxicology and Industrial Medicine Report No. 24-74. HEAST reference #005498 Sherman, H. 1974. Long-term feeding studies in rats and dogs with dichlorodifluoromethane (Freon 12 Food Freezant). Haskell Laboratory for Toxicology and Industrial Medicine Report No. 24-74. US EPA. 1987. Health Effects For Fully Halogenated Methanes. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC. US EPA. 1985. RfD/RfC Work Group.

L13

The NOEL from the 2-year rat study (15 mg/kg/day) and an uncertainty factor of 100 (10 for species extrapolation and 10 for sensitive individuals) were used to derive the RfD of 0.2 mg/kg/day, or 10 mg/day for a 70-kg human being.

A14


M14

10 for interspecies extrapolation, 3 for use of minimal LOAEL, and 10 for human variability

A15


C15

Intermediate-duration (15 to 364 days) oral MRL of 0.2 mg/kg/day based on LOAEL of 58 mg/kg/day.

G15

NTP. 1991a. Toxicological studies of 1,2-dichloroethane (ethylene dichloride) (CAS No. 107-06-2) in F344/N rats, Sprague Dawley rats, Osbourne-Mendel rats,and B6C3F1 mice (drinking water and gavage studies). Research Triangle Park, NC: US Department of Health and Human Services, Public Health Service, National Institute of Health, National Toxicology Program. NIH Publication No. 91-3123.

M15

10 for interspecies extrapolation, 3 for use of minimal LOAEL, and 10 for human variability

A16

Dichloroethene, 1,1- Synonyms: 1,1-Dichloroethene 1,1-DCE Dichloroethylene, 1,1- Ethylene, 1,1-dichloro- NCI-C54262 RCRA Waste Number U078 Sconatex UN 1303 Vinylidene chloride Vinylidene dichloride Vinylidine chloride VDC 1,1-Dichloroethylene

C16

NOAEL: 9 mg/kg-day LOAEL: 14 mg/kg-day BMDL10: 4.6 mg/kg-day

E16

minimal hepatocellular midzonal fatty change and hepatocellular swelling

G16

IRIS Oral RfD Principal Study Quast, JF; Humiston, CG; Wade, CE; et al. (1983) A chronic toxicity and oncogenicity study in rats and subchronic toxicity study in dogs on ingested vinylidene chloride. Fundam Appl Toxicol 3:55-62. IRIS Supporting Studies Humiston, CG; Quast, JF; Wade, CE; et al. (1978) Results of a two-year toxicity and oncogenicity study with vinylidene chloride incorporated in the drinking water of rats. Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical USA, Midland MI 48640. Rampy, LW; Quast, JF; Humiston, CG; et al. (1977) Interim results of two-year toxicological studies in rats of vinylidene chloride incorporated in the drinking water or administered by repeated inhalation. Environ. Health Perspect. 21:33-43. HEAST Rference #005419 Quast, JF; Humiston, CG; Wade, CE; et al. (1983) A chronic toxicity and oncogenicity study in rats and subchronic toxicity study in dogs on ingested vinylidene chloride. Fundam Appl Toxicol 3:55-62. US EPA. 1988. Updated Health Effects Assessment For 1,1-Dichloroethylene (Vinylidine Chloride). Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response. US EPA. 1989. RfD/RfC Work Group.

L16

A subchronic-to-chronic extrapolation factor was not applied because the study exposed the animals for 2 years. A database UF is not applied because the database is considered complete.

A17


A18


C18

NOAEL: 0.1 mg/L 17 mg/kg/day) LOAEL: 1 mg/L (175 mg/kg/day)

G18

IRIS Oral RfD Principal Study Barnes, D.W., V.M. Sanders, K.L. White, Jr., et al. 1985. Toxicology of trans-1,2-dichloroethylene in the mouse. Drug Chem. Toxicol. 8: 373-392.

L18

The UF of 1000 allows for uncertainty in the extrapolation of dose levels from laboratory animals to humans (10A), uncertainty in the threshold for sensitive humans (10H), and uncertainty in the effect of duration when extrapolating from subchronic to chronic exposure (10S).

A19


C19

Chronic MRL based on LOAEL of 125 mg/kg/day Intermediate MRL based on LOAEL of 100 mg/kg/day

G19

NTP (National Toxicology Program). 1986. Toxicology and carcinogenisis studies of 1,2-dichloroprane (propylene dichloride) in F344/N rats and B6C3F1 mice (gavage studies). Technical Report-No. 263. Bruckner JV, MacKenzie WF, Ramanathan R, et al. 1989. Oral toxicity or 1,2-dichloropropane: Acute short-term and long-term studies in rats. Fund Appl Toxicol 12: 713-730.

L19

10 for use of LOAEL, 10 for extrapolation from animals to humans, and 10 for human variability

M19

10 for use of LOAEL, 10 for extrapolation from animals to humans, and 10 for human variability

A20


C20

BMDL10: 3.4 mg/kg/day BMD10: 5.1 mg/kg/day

G20

IRIS Oral RfD Principal Study Stott, WT; Johnson, KA; Jeffries, TK; et al. (1995) Telone II soil fumigant: two-year chronic toxicity/oncogenicity study in Fischer 344 rats. The Dow Chemical Company. Midland, Michigan. Study # M-003993-0311. Supporting Studies NTP (National Toxicology Program). (1985) Toxicology and carcinogenesis studies of Telone II (technical grade 1,3-dichloropropene containing 1% epichlorohydrin as a stabilizer) in F344/N rats and B6C3F1 mice (gavage studies). U.S. Dept. of Health and Human Services, Technical Report Series No. 269. Redmond, JM; Stebbins, KE; Stott, WT. (1995) Telone II soil fumigant: two-year dietary chronic toxicity/oncogenicity study in B6C3F1 mice - final report. Dow Chemical Company, Midland, MI. Study # M-003993-032. Haut, KT; Stebbins, KE; Johnson, KA; et al. (1996) Subchronic toxicity of ingested 1,3-dichloropropene in rats and mice. Fundam Appl Toxicol 32:224-232. HEAST reference #005901 Dow Chemical Co. 1973. MRID NOS 00067977. 0039684. Available From EPA. Write FOI, EPA, Washington, DC 20460. US EPA. 1989. Health And Environmental Effects Document For 1,3-Dichloropropene. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergency Response. US EPA. 1987. RfD/RfC Work Group.

L20

The default uncertainty factor of 10 for interspecies extrapolation is applied because there are no data on the relative sensitivity of rats and humans to stomach irritation. Because there are no data documenting the nature and extent of variability in human susceptibilities to 1,3-dichloropropene, the default uncertainty factor of 10 is used for within-species variation. The database for 1,3-dichloropropene is substantial and includes studies of genotoxicity, mode of action, pharmacokinetics, reproductive and developmental toxicity, systemic toxicity, and cancer. Therefore, no additional uncertainty factors are needed.

A21


C21

Chronic MRL based on NOAEL of 9.6 mg/kg/day Intermediate MRL based on NOAEL of 60 mg/kg/day

G21

Kociba RJ, McCollister SB, Park C, et al. 1974. 1,4-Dioxane. I. Results of a 2-year ingestion study in rats. Toxicol Appl Pharmacol 30:275-286 JBRC. 1998b. Thirteen-week studies of 1,4-Dioxane in F344 rats and BDF1 mice (drinking water studies). Kanagawa, Japan. Japan Bioassay Research Center.

L21

10 for the protection of sensitive populations and 10 for animal to human extrapolation

M21

10 for the protection of sensitive populations and 10 for animal to human extrapolation

A22


C22

NOAEL: 500 mg/kg/day LOAEL: 2000 mg/kg/day

G22

IRIS Oral RfD Principal Study U.S. EPA. 1986. Rat oral subchronic study with ethyl ether. Prepared by American Biogenics Corporation for the Office of Solid Waste, Washington, DC.

L22

An uncertainty factor of 3000 reflects 10 to extrapolate from subchronic to chronic data, 10 for interspecies extrapolation, 10 to account for intraspecies variability, and an additional factor of 3 for lack of toxicity data in a second species and reproductive/developmental studies.

A23


C23

NOEL: 136 mg/kg/day (converted to 97.1 mg/kg/day) LOAEL: 408 mg/kg/day (converted to 291 mg/kg/day)

G23

IRIS Oral RfD Principal Study Wolf, M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth and F. Oyen. 1956. Toxicological studies of certain alkylated benzenes and benzene. Arch. Ind. Health. 14: 387-398.

L23

The uncertainty factor of 1000 reflects 10 for both intraspecies and interspecies variability to the toxicity of this chemical in lieu of specific data, and 10 for extrapolation of a subchronic effect level to its chronic equivalent.

A24


C24

NOAEL: 15 mg/kg/day LOAEL: 82 mg/kg/day NOAEL: 0.98 ppm (ATSDR) LOAEL: 2.95 ppm (ATSDR)

G24

IRIS Oral RfD Principal Study Til, H.P., R.A. Woutersen, V.J. Feron, V.H.M. Hollanders, H.E. Falke and J.J. Clary. 1989. Two-year drinking water study of formaldehyde in rats. Food Chem. Toxicol. 27: 77-87. ATSDR Reference Rusch GM, Clary JJ, Rinehart WE, et al. 1983. A 26-week inhalation toxicity study with formaldehyde in the monkey, rat, and hamster. Toxicol Appl Pharmacol 68:329-343.

L24

An uncertainty factor of 100 was used to account for the inter- and intraspecies differences.

M24


A25


C25

NOAEL: 200 mg/kg/day

G25

HEAST reference #010268 Malorny G. 1969. Acute And chronic Toxicity Of Formic Acid And Formate. Z Ernachrungswiss. 9:332-339. US EPA. 1990. RfD/RfC Work Group.

A26


C26

LOAEL: 570 mg/kg/day

G26

HEAST reference #005974 Krasavage WJ, JL O'Donoghue, GD Divincenzo And Terhaar. 1980. Relative Neurotoxicity Of Methyl-N-Butyl Ketone, N-Haxane, And Their Metabolites. Toxicol Appl Pharmacol. 52(3): 433-441. US EPA. 1989. Health And Environmental Effects Document For N-Hexane. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergency Response, Washington, DC.

A27


C27

NOEL: 316 mg/kg/day LOAEL: 1000 mg/kg/day

G27

IRIS Oral RfD Principal Study U.S. EPA. 1986. Rat oral subchronic toxicity study with isobutyl alcohol. Office of Solid Waste, Washington, DC.

L27

An uncertainty factor of 1000 was applied: 10 for interspecies extrapolation, 10 for intraspecies variability and 10 for extrapolating subchronic exposure to chronic exposure.

A28


C28


G28

IRIS Oral RfD Principal Study U.S. EPA. 1986. Rat oral subchronic toxicity study with methanol. Office of Solid Waste, Washington, DC.

L28

An uncertainty factor (10A) was used to account for interspecies extrapolation, (10H) for range of sensitivity within the human population to xenobiotics and (10S) to account for extrapolation from subchronic to chronic exposure.

A29


C29

NOAEL: 594 mg/kg-day (0.3% 2-butanol solution) LOAEL: 1,771 mg/kg-day (1% 2-butanol solution)

G29

IRIS Oral RfD Principal Study Cox, GE; Bailey, DE; Morgareidge, K. (1975) Toxicity studies in rats with 2-butanol including growth, reproduction and teratologic observations. Food and Drug Research Laboratories, Inc., Waverly, NY. Report No. 91MR R 1673. HEAST reference #010853 Cox, GE; Bailey, DE; Morgareidge, K. (1975) Toxicity studies in rats with 2-butanol including growth, reproduction and teratologic observations. Food and Drug Research Laboratories, Inc., Waverly, NY. Report No. 91MR R 1673. US EPA. 1992. RfD/RfC Work Group.

L29

A 10-fold uncertainty factor was used to account for laboratory animal-to-human interspecies differences. A 10-fold uncertainty factor for intraspecies differences was used to account for potentially susceptible human subpopulations. A 10-fold uncertainty factor was used to account for deficiencies in the available MEK database.

A30


C30


G30

HEAST reference #010949 Microbiological Associates. 1986. Subchronic Toxicity Of Methyl Isobutyl Ketone In Sprague-Dawley Rats. Performed For Research Triangle Institute, PO Box 12194, Research Triangle Park, NC, 27709. Final Report. Study NO 522104. US EPA. 1993. RfD/RfC Work Group.

A31


C31

Intermediate MRL based on LOAEL of 100 mg/kg/day

G31

Robinson M, Bruner, RH, Olson GR. 1990. Fourteen- and 90-day oral toxicity studies of methyl tertiary-butyl ether in Sprague-Dawley rats. Health Effects Research Lab, U.S. Environmental Protection Agency, Cincinnati. J Am Coll Toxicol 9(ISS 5):525-540.

M31

3 for use of LOAEL, 10 for extrapolation from animals to humans, and 10 for human variability.

A32


A33


C33

NOAEL: 200 mg/kg-day LOAEL: 400 mg/kg-day

G33

IRIS Oral RfD Principal Study Quast, J.F., C.G. Humiston, R.Y. Kalnins, et al. 1979. Results of a toxicity study of monomeric styrene administered to beagle dogs by oral intubation for 19 months. Toxicology Research Laboratory, Health and Environmental Sciences, DOW Chemical Co., Midland, MI. Final Report.

L33

The uncertainty factor of 1000 reflects 10 for both intraspecies and interspecies variability to the toxicity of this chemical in lieu of specific data, and 10 for extrapolation of subchronic effects to chronic effects.

A34


C34

LOAEL: 125 mg/kg/day (converted to 89.3 mg/kg/day)

G34

IRIS Oral RfD Principal Study NTP (National Toxicology Program). 1983. Carcinogenesis studies of 1,1,1,2- tetrachloroethane in F344/N rats and B6C3F1 mice. NTP, Washington, DC. HEAST reference #010407 NTP (National Toxicology Program). 1983. Carcinogenesis studies of 1,1,1,2- tetrachloroethane in F344/N rats and B6C3F1 mice. NTP, Washington, DC. US EPA. 1987. RfD/RfC Work Group. US EPA. 1993. Revised And Updated Drinking Water Quantification Of Toxicological Effects For Tetrachloroethane, 1,1,1,2-. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Water, Washington, DC.

L34

An uncertainty factor of 3000 was used: 10 to extrapolate from a LOAEL, 10 for interspecies extrapolation and 10 to provide additional protection for unusually sensitive individuals, and an additional factor of 3 for lack of adequate supporting reproductive and chronic toxicity studies.

A35


C35

Intermediate MRL based on BMD of 82.89 mg/kg/day and corresponding BMDL10 of 53.88 mg/kg/day

G35

NTP. 2004. NTP technical report on the toxicity studies of 1,1,2,2-tetrachloroethane (CAS No. 79-34-5) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. National Toxicology Program. Tox-49. http://ntp.niehs.nih.gov/ntp/htdocs/ST_rpts/tox049.pdf. October 04, 2004.

M35

10 for interspecies extrapolation and 10 for human variability

A36

Tetrachloroethene Synonyms: Ankilostin Antisal 1 or Antisol 1 Carbon bichloride Carbon dichloride Czterochloroetylen Dee-Solv Didakene or Didokene Dowclene EC Dow-Per ENT 1,860 Ethene, tetrachloro- Ethylene tetrachloride Ethylene, tetrachloro- Fedal-Un NCI-C04580 Nema PCE PER Perawin PERC Perchloorethyleen, per Perchlor Perchloraethylen, per Perchlorethylene Perchlorethylene, per Perchloroethylene Perclene Percloroetilene Percosolv Percosolve PERK Perklone Persec Tetlen Tetracap Tetrachlooretheen Tetrachloraethen Tetrachlorethylene Tetrachloroethene Tetrachloroethylene 1,1,2,2-Tetrachloroethylene. Tetracloroetene Tetraguer or Tetraleno Tetralex or Tetravec Tetroguer Tetropil WLN: GYGUYGG

C36

NOAEL: 20 mg/kg/day (converted to 14 mg/kg/day) LOAEL: 100 mg/kg/day (converted to 71 mg/kg/day)

G36

IRIS Oral RfD Principal Study Buben, J.A. and E.J. O'Flaherty. 1985. Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose- effect study. Toxicol. Appl. Pharmacol. 78: 105-122. Supporting Study Hayes, J.R., L.W. Condie, Jr. and J.F. Borzelleca. 1986. The subchronic toxicity of tetrachloroethylene (perchloroethylene) administered in the drinking water of rats. Fund. Appl. Toxicol. 7: 119-125.

L36

The uncertainty factor of 1000 results from multiplying factors of 10 to account for intraspecies variability, interspecies variability and extrapolation of a subchronic effect level to its chronic equivalent.

A37


C37

BMDL: 238 mg/kg-day BMD: 431 mg/kg-day

G37

IRIS Oral RfD Principal Study NTP (National Toxicology Program). (1990) Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies). Public Health Service, U.S. Department of Health and Human Services; NTP TR 371. Available from: National Institute of Environmental Health Sciences, Research Triangle Park, NC.

L37

A total uncertainty factor (UF) of 3000 was applied to this effect level: 10 for extrapolation for interspecies differences (UFA; animal to human), 10 for consideration of intraspecies variation (UFH; human variability), 10 for use of a subchronic study to estimate chronic effects (UFS; duration of exposure), and 3 for database insufficiencies and contradictions in the immunotoxicity data (UFD). The total UF = 10 x 10 x 10 x 3 = 3000.

A38


C38

NOAEL: 875 ppm ATSDR MRL based on NOAEL: 2820 mg/kg/day

G38

Quast, J.F., L.W. Rampy, M.F. Balmer, B.K.J. Leong, and P.J. Gehring. 1978. Toxicological and carcinogenic evaluation of a 1,1,1-Trichloroethane formulation by chronic inhalation in rats. Unpublished study. Toxicology Research Laboratory, Health and Environmental Sciences, The Dow Chemical Company, Midland, MI (as cited in ATSDR 1993). Reitz, R.H., R.J. Nolan, and A.M. Schumann. 1987. Development of multispecies, multiroute pharmacokinetic models for methylene chloride and 1,1,1-trichloroethane (methyl chloroform). In: Drinking Water and Health, Vol 8, R.D. Thomas, Ed. National Academy Press, Washington, DC. Reitz, R.H., J.N. McDougal, M.W. Himmelstein, R.J. Nolan, and A.M. Schumann. 1988. Physiologically based pharmacokinetic modeling with methylchloroform: Implications for interspecies, highdose/low/dose, and dose route extrapolations. Toxicol. Appl. Pharmacol. 95: 185-199. NTP. 2000. NTP technical report on the toxicity studies of 1,1,1-Trichloroethane administered in microcapsules in feed F344/N rats and B6C3F1 mice. National Toxicology Program. (41) NIH 004402.

L38

10 for intraspecies variation, 3 for uncertainty of PBPK model parametrization, and 3 for database deficiencies.

M38

10 for extrapolation from animals to humans, 10 for human variability

A39


C39

NOAEL: 20 mg/L (drinking water) (3.9 mg/kg/day) LOAEL: 200 mg/L (drinking water) (44 mg/kg/day)

G39

IRIS Oral RfD Principal Studies Sanders, V.M., K.L. White, Jr., G.M. Shopp, Jr. and A.E. Munson. 1985. Humoral and cell-mediated immune status of mice exposed to 1,1,2- trichloroethane. Drug Chem. Toxicol. 8(5): 357-372. White, K.L., Jr., V.M. Sanders, V.W. Barnes, G.M. Shopp, Jr. and A.E. Munson. 1985. Toxicology of 1,1,2-trichloroethane in the mouse. Drug Chem. Toxicol. 8(5): 333-355.

L39

The UF includes the standard uncertainty factors for interspecies and intrahuman variability, and a factor of 10 for extrapolation to lifetime exposure from an intermediate exposure duration.

A40

Trichloroethene Synonyms: ACETYLENE TRICHLORIDE ALGYLEN ANAMENTH BENZINOL BLACOSOLV BLANCOSOLV CECOLENE CHLORILEN 1-CHLORO-2,2-DICHLOROETHYLENE CHLORYLEA CHLORYLEN CHORYLEN CIRCOSOLV CRAWHASPOL DENSINFLUAT 1,1-DICHLORO-2-CHLOROETHYLENE DOW-TRI DUKERON ETHINYL TRICHLORIDE ETHYLENE TRICHLORIDE ETHYLENE, TRICHLORO- FLECK-FLIP FLOCK FLIP FLUATE GEMALGENE GERMALGENE LANADIN LETHURIN NARCOGEN NARKOGEN NARKOSOID NCI-C04546 NIALK PERM-A-CHLOR PERM-A-CLOR PETZINOL PHILEX RCRA WASTE NUMBER U228 TCE THRETHYLEN THRETHYLENE TRETHYLENE TRI or TRIAD or TRIAL TRIASOL TRICHLOORETHEEN TRICHLOORETHYLEEN, TRI TRICHLORAETHEN TRICHLORAETHYLEN, TRI TRICHLORAN or TRICHLOREN TRICHLORETHYLENE, TRI TRICHLOROETHENE Trichloroethylene 1,1,2-TRICHLOROETHYLENE 1,2,2-TRICHLOROETHYLENE TRI-CLENE TRICLORETENE TRICLOROETILENE TRIELENE or TRIELIN TRIELINA or TRIKLONE TRILEN or TRILENE TRILINE or TRIMAR TRIOL or TRI-PLUS TRI-PLUS M UN 1710 VESTROL VITRAN WESTROSOL

C40

BMD10 1.0 mg/L (1ppm)

G40

CAL/EPA 199, Public Health Goal For Trichlorethylene in Drinking Water, Office Of Health Hazard Assessment, California Environmental Protection Agency, http://www.oehha.ca.gov/water/phg/pdf/tce_f.pdf

A41


C41

LOAEL: 488 mg/kg/day converted to 349 mg/kg/day

G41

IRIS Oral RfD Principal Study NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane for possible carcinogenicity. Report. No. 106, PHS/NIH, DHEW Publ. No. 78- 1356. HEAST reference #005502 NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane for possible carcinogenicity. Report. No. 106, PHS/NIH, DHEW Publ. No. 78- 1356. US EPA. 1987. Health Effects Assessment For Fully Hlaogenated Methanes. Prepared By The Office Of Health And Environmentla Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC. US EPA. 1985. RfD/RfC Work Group. HEAST reference #005500 NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane for possible carcinogenicity. Report. No. 106, PHS/NIH, DHEW Publ. No. 78- 1356. US EPA. 1987. Health Effects Assessment For Fully Hlaogenated Methanes. Prepared By The Office Of Health And Environmentla Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

L41

An uncertainty factory of 1000 (10 for LOAEL, 10 for species conversion, and 10 for sensitive human population), results in an RfD of 0.3 mg/kg/day.

A42


C42

NOAEL: 8 mg/kg/day, 5 days/week converted to 5.71 mg/kg/day LOAEL: 16 mg/kg/day, 5 days/week converted to 11.4 mg/kg/day

E42

general toxicity liver lesions kidneu lesions decrease erythrocytes count decreased hematocrit decreased hemoglobin

G42

IRIS Oral RfD Principal Study NTP (National Toxicology Program). 1983. 120-Day gavage study in mice and rats with 1,2,3-trichloropropane. Unpublished report prepared by Hazleton Laboratories.

L42

An uncertainty factor of 1000 was used; 10 for intraspecies, 10 for interspecies extrapolation, and 10 for extrapolating subchronic to chronic exposures.

A43


C43

NOAEL: 0.13 mg/kg-day NOAEL (HED): 0.09 mg/kg-day LOAEL: 1.3 mg/kg-day LOAEL (HED): 0.9 mg/kg-day

G43

IRIS Oral RfD Principal Studies Til, HP; Immel, HR; Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353. Til, HP; Feron, VJ; Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718.

L43

An uncertainty factor of 10 was used for protection of sensitive human subpopulations and 3 for animal-to-human extrapolation. The uncertainty factor for intraspecies variability includes the variability in risk estimates that would be predicted by the PBPK model for different individuals through variability in physiology, level of activity, and metabolic capability. A factor of 3 rather than a default of 10 was used for interspecies extrapolation because, although PBPK modeling refines the animal-to-human comparison regarding the toxicokinetic portion (delivered dose), it does not address the uncertainty regarding the toxicodynamic portion (differential tissue sensitivity) of interspecies extrapolation. Uncertainty relating to toxicodynamics exists for the basic mode of action for noncancer liver effects, that is, whether the epoxide or its rearrangement product (the aldehyde) are causal of the noncancer liver toxicity. The limited evidence of human susceptibility to certain hepatic effects of VC from the problematic study of Ho et al. (1991) also supports retaining the toxicodynamic portion of the interspecies UF (see Toxicological Review Section 4.1.2). No uncertainty factor for database insufficiency is considered necessary, because adequate chronic, developmental, and multigeneration reproductive studies exist. The total uncertainty factor is 30.

A44


C44

NOAEL: 250 mg/kg-day (179 mg/kg-day)* LOAEL: 500 mg/kg-day

G44

IRIS Oral RfD Principal Study NTP (National Toxicology Program). (1986) NTP technical report on the toxicology and carcinogenesis of xylenes (mixed) (60% m-xylene, 13.6% p-xylene, 17.0% ethylbenzene, and 9.1% o-xylene) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC. NTP TR 327, NIH Publ. No. 86-2583.

L44

A UF of 10 was applied to account for laboratory animal-to-human interspecies differences. No information is available to support a change from default. A UF of 10 was applied for intraspecies uncertainty to account for human variability and sensitive populations. This factor accounts for humans who may be more sensitive than the general population to exposure to xylenes. A UF of 10 was used to account for database uncertainty.

A46


C46


G46

IRIS Oral RfD Principal Study U.S. EPA. 1989. Mouse oral subchronic study with acenaphthene. Study conducted by Hazelton Laboratories, Inc., for the Office of Solid Waste, Washington, DC.

L46

An uncertainty factor of 3000 reflects 10 each for inter- and intraspecies variability, 10 for the use of a subchronic study for chronic RfD derivation, and 3 for the lack of adequate data in a second species and reproductive/developmental data.

A47


C47

NOAEL: 10,000 ppm (423 mg/kg/day)

G47

IRIS Oral RfD Principal Study Hagan, E.C., W.H. Hansen, O.G. Fitzhugh, et al. 1967. Food flavorings and compounds of related structure. II. Subacute and chronic toxicity. Food Cosmet. Toxicol. 5: 141-157.

L47

UF -- 10 for species to species extrapolation, 10 to protect sensitive humans, 10 to extrapolate from subchronic to chronic exposure, and 3 for the lack of important reproductive toxicity data.

A48


C48

NOAEL: 4.2 mg/kg/day LOAEL: 10 mg/kg/day

G48

ATSDR Reference Bio/dynamics. 1980b. A twenty-four month oral toxicity/carcinogenicity study of acrylonitrile administered in the drinking water to Fischer 344 rats. Biodynamics, Inc., Division of Biology and Safety Evaluation,East Millstone, NJ. Project No. BDN-77-27. Tandon R, Saxena DK, Chandra SV, et al. 1988. Testicular effects of acrylonitrile in mice. Toxicol Lett 42:55-63.

L48


M48

10 for extrapolation from animals to humans, 10 for use of LOAEL, and 10 for human variability

A49


A50


C50

NOEL: 1000 mg/kg/day

G50

IRIS Oral RfD Principal Study U.S. EPA. 1989. Subchronic toxicity in mice with anthracene. Final Report. Hazelton Laboratories America, Inc. Prepared for the Office of Solid Waste, Washington, DC.

A51


C51

LOAEL: 20 ppm in drinking water (2.7 mg/kg/day)

G51

IRIS Oral RfD Principal Study Littlefield, N.A., C.J. Nelson and C.H. Frith. 1983. Benzidine dihydrochloride: Toxicological assessments in mice during chronic exposures. J. Toxicol. Environ. Health. 12: 671-685. HEAST reference #005830 Littlefield, N.A., C.J. Nelson and C.H. Frith. 1983. Benzidine dihydrochloride: Toxicological assessments in mice during chronic exposures. J. Toxicol. Environ. Health. 12: 671-685. Fairchild, EJ And HE Stokinger. 1958. Toxicologic Studies On Organic Sulfur Compounds. 1. Acute Toxicity Of Some Aliphatic And Aromatic Thiols (Mercaptans). Am. Ind. Hyg. Assoc. J 19: 171-189. US EPA. 1987. RfD/RfC Work Group. HEAST reference #010877 US EPA. 1991. RfD/RfC Work Group.

L51

The UF of 1000 allows for uncertainty in the extrapolation of dose levels from laboratory animals to humans (10A), uncertainty in the threshold for sensitive humans (10H), and uncertainty in the estimation of a NOAEL from a LOAEL (10L) (IRIS).

A52


A53


A54


A55


A56


C56

LOAEL: 0.04% of diet (19 mg/kg bw/day)

G56

IRIS Oral RfD Principal Study Carpenter, C.P., C.S. Weil and H.F. Smyth. 1953. Chronic oral toxicity of di(2-ethylhexyl)phthalate for rats and guinea pigs. Arch. Indust. Hyg. Occup. Med. 8: 219-226.

L56

Factors of 10 each were used for interspecies variation and for protection of sensitive human subpopulations. An additional factor of 10 was used since the guinea pig exposure was longer than subchronic but less than lifetime, and because, while the RfD is set on a LOAEL, the effect observed was considered to be minimally adverse.

A57


C57

NOAEL: 2800 ppm (159 mg/kg/day) LOAEL: 8300 ppm (470 mg/kg/day)

E57

altered liver-to-body weight and liver-to-brain weight ratios

G57

IRIS Oral RfD Principal Study NTP (National Toxicology Program). 1985. Twenty-six week subchronic study and modified mating trial in F344 rats. Butyl benzyl phthalatee. Final Report. Project No. 12307-02, -03. Hazelton Laboratories America, Inc. Unpublished study.

L57

UF -- 10 for intraspecies sensitivity, 10 for interspecies variability and 10 for extrapolating from subchronic to chronic NOAELs.

A59


C59

NOAEL: 0.15 mg/kg-day LOAEL: 0.75 mg/kg-day

G59

IRIS Oral RfD Principal and Supporting Studies Khasawinah, A.M. and J.F. Grutsch. 1989a. Chlordane: 24-month tumorigenicity and chronic toxicity test in mice. Reg. Toxicol. Pharmacol. 10: 244-254. Velsicol Chemical Corporation. 1983. Twenty-four month chronic toxicity and tumorigenicity test in mice by chlordane technical. Unpublished study by Research Institute for Animal Science in Biochemistry and Toxicology, Japan. MRID No. 00144312, 00132566. Available from U.S. EPA. HEAST reference #005296 Velsicol Chemical Corporation. 1983. Twenty-four month chronic toxicity and tumorigenicity test in mice by chlordane technical. Unpublished study by Research Institute for Animal Science in Biochemistry and Toxicology, Japan. MRID No. 00144312, 00132566. Available from U.S. EPA. US EPA. 1995. RfD/RfC Work Group.

L59

The following uncertainty factors are applied to the NOAEL derived from the principal study: 10 for consideration of intraspecies variation, 10 for consideration of interspecies extrapolation, and 3 for lack of any reproductive studies.

A60


A61


A62


C62

NOAEL: 120 mg/kg/day (adjusted to 85.7 mg/kg/day)

L62

The UF of 1000 allows for uncertainty in the extrapolation of dose levels from laboratory animals to humans (10A), uncertainty in the threshold for sensitive humans (10H), and uncertainty because of the lack of studies assessing reproductive effects and adequate chronic toxicity in a second species (10D).

A63


C63

BMDL1sd: 9.97 kg/mg/day NOAEL: 10 mg/kg/day LOAEL: 50 mg/kg/day

G63

Naylor MW, Stout LD. 1996. One-year study of p-dichlorobenzene administered orally via capsule to beagle dogs. Environmental Health Laboratory, Monsato Company, St. Louis, MO. Study No. ML-94-210, March 25, 1996. MRID43988802. Unpublished study.

L63


A64


A65


A66


A67


C67

NOEL: 1 ppm diet (0.05 mg/kg bw/day) LOAEL: 5 ppm

G67

IRIS Oral RfD Principal Study Laug, E.P., A.A. Nelson, O.G. Fitzhugh and F.M. Kunze. 1950. Liver cell alteration and DDT storage in the fat of the rat induced by dietary levels of 1-50 ppm DDT. J. Pharmacol. Exp. Therap. 98: 268-273.

L67

A factor of 10 each was applied for the uncertainty of interspecies conversion and to protect sensitive human subpopulations. An uncertainty factor for subchronic to chronic conversion was not included because of the corroborating chronic study in the database.

A68


C68

NOAEL: 1.0 mg/kg/day LOAEL: 5.0 mg/kg/day

G68

IRIS Oral RfD Principal Study Dow Chemical Co. 1983. Acc. No. 251473. Available from EPA. Write to FOI, EPA, Washington, DC 20460. HEAST reference #01265 Dow Chemical Co. 1983. Acc. No. 251473. Available from EPA. Write to FOI, EPA, Washington, DC 20460. US EPA. 1988. RfD/RfC Work Group.

L68

The 100-fold uncertainty factor accounts for both interspecies and interhuman variability in the toxicity of this chemical in lieu of specific data. Because an analysis of the 90-day and 1-year interim results suggests that the NOAEL would hold for the full 2-year duration, inclusion of the subchronic-to-chronic UF is not warranted.

A69


C69

NOAEL: 1% of diet (750 mg/kg bw/day) LOAEL: 5% of diet (3160 mg/kg bw/day)

G69

IRIS Oral RfD Principal Study Brown, D., K.R. Butterworth, I.F. Gaunt, P. Grasso and S.D. Gangolli. 1978. Short-term oral toxicity study of diethyl phthalate in the rat. Food Cosmet. Toxicol. 16: 415-422.

L69

A factor of 10 for extrapolation from subchronic to chronic exposure, 10 for interspecies variation, and an additional 10-fold factor to protect sensitive human subpopulations were used in determining the RfD.

A70


C70


G70

IRIS Oral RfD Principal Study U.S. EPA. 1989. Ninety-day gavage study in Albino mice using 2,4- dimethylphenol. Study No. 410-2831, prepared by Dynamac Corporation, Rockville, MD, for the Office of Solid Waste and Emergency Response, Washington, DC.

L70

An uncertainty factor of 3000 was established: 10 each for inter- and intraspecies variability and 30 for lack of chronic toxicity data, data in a second species and reproductive/developmental studies.

A71


C71

NOAEL: 0.25% of diet (125 mg/kg/day) LOAEL: 1.25% of diet (600 mg/kg bw/day)

G71

IRIS Oral RfD Principal Study Smith C.C. 1953. Toxicity of butyl sterate, dibutyl sebacate, dibutyl phthalate and methoxyethyl oleate. Arch. Hyg. Occup. Med. 7: 310-318.

L71

A factor of 10 was applied to account for interspecies variation, a factor of 10 for protection of sensitive human subpopulations, and an additional factor of 10 to account for both the less-than-chronic duration of the study and deficiencies in the study, such as the use of only male animals.

A72


C72

NOAEL: 3 ppm (0.40 mg/kg/day) LOAEL: 8 ppm

G72

IRIS Oral RfD Princopal Study Cody, T.E., S. Witherup, L. Hastings, K. Stemmer and R.T. Christian. 1981. 1,3-Dinitrobenzene: Toxic effect in vivo and in vitro. J. Toxicol. Environ. Health. 7(5): 829-847.

L72

UF — 10 for extrapolation from subchronic to chronic exposure, 10 for extrapolation across species, 10 for sensitive human subgroups, and 3 for the lack of subchronic and reproductive toxicity data.

A73


A74


C74


E74

Neurotoxic effect, characterized by incoordination and paralysis, methemoglobinemia with associated reticulocytosis and Heinz bodies; biliary tract hyperplasia; and pigmentation of the gallbladder, kidneys, and spleen. lesions included vacuolization, endothelial proliferation, and gliosis of the cerebellum.

G74

IRIS Oral RfD Principal Study Ellis, H.V., C.B. Hong, C.C. Lee, J.C. Dacre and J.P. Glennon. 1985. Subchronic and chronic toxicity studies of 2,4-dinitrotoluene. Part I. Beagle dogs. J. Am. College Toxicol. 4(4): 233-242. HEAST reference #005941 Ellis, H.V., C.B. Hong, C.C. Lee, J.C. Dacre and J.P. Glennon. 1985. Subchronic and chronic toxicity studies of 2,4-dinitrotoluene. Part I. Beagle dogs. J. Am. College Toxicol. 4(4): 233-242. US EPA. 1986. Health Adn Environmental Effects Profile For Dinitrotoluene. Prepared By Office Of Health And Environmental Assessment, Environmental Criteria And assessment Office, Cincinnati, OH For The Office Of Solid Waste Adn Emergency Response, Washington, DC. US EPA. 1991. RfD/RfC Work Group.

L74

This uncertainty factor includes a factor of 10 for interspecies variability and a factor of 10 for intraspecies variability.

A75


A76


C76

NOEL: 1 ppm in diet (0.025 mg/kg/day) LOAEL: 2 ppm in diet (0.05 mg/kg/day) NOAEL: 0.15 mg/kg/day (4 ppm) (ATSDR)

G76

IRIS Oral RfD Principal Study Velsicol Chemical Corporation. 1969. MRID. No. 00030198. Available from EPA. Write FOI, EPA, Washington, DC. 20460. ATSDR Reference Treon JF, Cleveland FP, Cappel J. 1955. Toxicity of endrin for laboratory animals. Agricultural and Food Chemistry 3:842-848.

L76

The UF of 100 allows for uncertainty in the extrapolation of dose levels from laboratory animals to humans (10A) and uncertainty in the threshold for sensitive humans (10H).

M76


A77


C77


G77

IRIS Oral RfD Principal Study DePass, L.R., R.H. Garman, M.D. Woodside, et al. 1986a. Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice. Fund. Appl. Toxicol. 7: 547-565. HEAST reference #005454 DePass, L.R., R.H. Garman, M.D. Woodside, et al. 1986a. Chronic toxicity and oncogenicity studies of ethylene glycol in rats and mice. Fund. Appl. Toxicol. 7: 547-565. US EPA. 1987. RfD/RfC Work Group.

L77

The UF of 100 included 10 for interspecies extrapolation and 10 for differences in individual human sensitivity.

A78


C78


G78

IRIS Oral RfD Principal Study U.S. EPA. 1988. 13-Week mouse oral subchronic toxicity study. Prepared by Toxicity Research Laboratories, Ltd., Muskegon, MI for the Office of Solid Waste, Washington, DC.

L78

An uncertainty factor of 3000 reflects 10 for interspecies conversion, 10 for intraspecies variability, and 30 for use of a subchronic study for chronic RfD derivation, and for lack of supporting reproductive/developmental toxicity data and toxicity data in a second species.

A79


C79


G79

IRIS Oral RfD Principal Study U.S. EPA. 1989. Mouse oral subchronic toxicity study. Prepared by Toxicity Research Laboratories, LTD., Muskegon, MI for the Office of Solid Waste, Washington, DC.

L79

An uncertainty factor of 3000 was used: 10 for use of a subchronic study for chronic RfD derivation, 10 each for inter- and intraspecies variability, and 3 for lack of adequate toxicity data in a second species and reproductive/developmental data.

A80


C80

NOEL: 3 ppm diet (0.15 mg/kg/day) LEL: 5 ppm diet (0.25 mg/kg/day) LOAEL: 0.03 mg/kg/day (ATSDR)

G80

IRIS Oral RfD Principal Study Velsicol Chemical Corporation. 1955a. MRID No. 00062599. Available from EPA. Write to FOI, EPA, Washington, DC 20460. ATSDR Reference Smialowicz RJ, Williams WC, Copeland CB, et al. 2001. The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats. Toxicol Sci 61(1):164-175.

L80

Based on a chronic exposure study, an uncertainty factor of 100 was used to account for inter- and intraspecies differences. An additional factor of 3 was considered appropriate because of the lack of chronic toxicity data in a second species, for a total uncertainty factor of 300. The serious deficiencies in the toxicologic database would normally warrant a 10-fold factor for this area of uncertainty. However, toxicity data for other cyclodiene insecticides (aldrin, dieldrin, chlordane, and heptachlor epoxide) suggest that dogs and rats do not differ greatly in sensitivity to the effects of this class of compounds. Furthermore, liver toxicity has been fairly well established as the most sensitive endpoint for this class of compounds, which reduces the uncertainty attributable to the lack of information on other toxic effects.

M80

3 for use of a minimal LOAEL, 10 for extrapolation from animals to humans, and 10 for human variability

A81


C81

LEL: 0.5 ppm (diet) (0.0125 mg/kg/day)

G81

IRIS Oral RfD Principal Study Dow Chemical Company. 1958. MRID No. 00061912. Available from EPA. Write to FOI, EPA, Washington, DC 20460. HEAST reference #010399 Dow Chemical Company. 1958. MRID No. 00061912. Available from EPA. Write to FOI, EPA, Washington, DC 20460. US EPA. 1986. RfD/RfC Work Group.

L81

Based on a chronic exposure study, an uncertainty factor of 1000 was used to account for inter- and intraspecies differences and to account for the fact that a NOEL was not attained.

A82


C82

NOAEL: 1.6 ppm (diet) (0.08 mg/kg/day) LOAEL: 8.0 ppm (diet) (0.29 mg/kg/day) LOAEL: 0.2 mg/kg/day (ATSDR)

G82

IRIS Oral RfD Principal Study Arnold, D.L., C.A. Moodie, S.M. Charbonneau, et al. 1985. Long-term toxicity of hexachlorobenzene in the rat and the effect of dietary Vitamin A. Fd. Chem. Toxic. 23(9): 779-793. ATSDR Reference NTP. 1991. National Toxicology Program. Toxicity studies of hexachloro-1,3-butadiene in B6C3F1 mice (feed studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. NIH publication no. 91-3120. Yang RS, Abdo KM, Elwell MR. 1989. Subchronic toxicology studies of hexachloro-1,3-butadiene (HCBD) in B6C3F1 mice by dietary incorporation. JEPTO 9:323-332.

L82

An uncertainty factor of 100 was applied; 10 for interspecies and 10 for intraspecies variability.

M82

10 for extrapolation from animals to humans, 10 for use of LOAEL, and 10 for human variability

A83


C83

LOAEL: 0.5 mg/kg/day

G83

HEAST reference #010927 NTP (National Toxicology Program). 1991. NTP Report On The Toxicity Studies Of Hexachloro-1,3-Butadiene In B6C3F1 Mice (Feed Studies). Yang Et Al. 1989. Hexachlrobutadiene - Subchronic Toxicological Studies Of Hexachloro-1,3-Butadiene (HCBD) In B6C3F1 Mice By Dietary Incorporation. J Environ Pathol Toxicol Oncol. p. 323-332. Kociba RJ. DG Keys. GC Jersey, Et Al. 1977. Results Of A 2-Year Chronic Toxicity Study With Hexachlorobutadiene In Rats. Am Ind Hyg Assoc J. 39: 589-602. US EPA. 1993. RfD/RfC Work Group.

A84


C84


G84

IRIS Oral RfD Principal Study Gorzinski, S.J., R.J. Nolan, S.B. McCollister, R.J. Kociba and J.L. Mattsson. 1985. Subchronic oral toxicity, tissue distribution and clearance of hexachloroethane in the rat. Drug Chem. Toxicol. 8(3): 155-169.

L84

An uncertainty factor of 1000 was used: 10 to account for interspecies extrapolation, 10 for the range of sensitivity within the human population to xenobiotics and 10 for the use of a subchronic study.

A85


A86


C86

NOEL: 150 mg/kg/day LEL: None

G86

IRIS Oral RfD Principal And Supporting Studies Nor-Am Agricultural Products, Inc. 1972a. MRID No. 00123976. Available from EPA. Write to FOI, EPA, Washington, DC 20460. Nor-Am Agricultural Products, Inc. 1972b. MRID No. 00123977. Available from EPA. Write to FOI, EPA, Washington DC. 20460. NTP (National Toxicology Program). 1984. NTP Technical Report on the Toxicology and Carcinogenisis Studies of Isophorone in F344/N Rats and B63F1 Mice (Gavage). NIH Publication No. 84-2547, NTP-83-168.

L86

An uncertainty factor of 100 was used to account for the inter- and intraspecies differences. An additional UF of 10 was used to account for the use of a subchronic study. (The use of the chronic study to estimate the RfD would not evoke this latter 10-fold factor, but would necessitate a 10-fold factor for the use of a LOAEL. In either case the RfD is the same.)

A87


C87

NOAEL: 154 mg/kg-day adjusted to 110 mg/kg-day LOAEL: 462 mg/kg-day adjusted to 331 mg/kg-day

G87

IRIS Oral RfD Principal Study Wolf, M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth, and F. Oyen. 1956. Toxicological studies of certain alkylated benzenes and benzenes. Arch. Ind. Health. 14: 387-398.

L87

The following uncertainty factors are applied: 10 for extrapolation for intraspecies differences and 10 for consideration of interspecies variation. A partial UF of 3 is applied for subchronic-to- chronic duration extrapolation. Justification for the use of a partial UF for subchronic-to-chronic extrapolation was that the duration of the study (6 to 7 months) is intermediate between subchronic (3 months) and chronic (24 months) duration. A partial UF also is used for database deficiencies (lack of reproductive information). The total UF = 10 x 10 x 3 x 3, which is rounded to 1000.

A88


C88

NOAEL: 4 ppm diet [0.33 mg/kg/day (females)] LOAEL: 20 ppm diet [1.55 mg/kg/day (males)]

G88

IRIS Oral RfD Principal Study Zoecon Corporation. 1983. MRID No. 00128356. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.

L88

A factor of 10 each was employed for use of a subchronic vs. a lifetime assay, to account for interspecies variation and to protect sensitive human subpopulations.

A89


C89


G89

IRIS Oral RfD Principal Studies U.S. EPA. 1986. o, m, p-Cresol. 90-Day oral subchronic toxicity studies in rats. Office of Solid Waste, Washington, DC. U.S. EPA. 1987. o, m, p-Cresol. 90-Day oral subchronic neurotoxicity study in rats. Office of Solid Waste, Washington, DC.

L89

10 for interspecies and 10 for intraspecies variability and 10 for uncertainty in extrapolation of subchronic data to levels of chronic effects.

A90


C90

NOEL: 5.01 mg/kg/day LEL: 35.5 mg/kg/day LOAEL: 5 mg/kg/day (ATSDR)

G90

IRIS Oral RfD Principal Study Kincaid Enterprises, Inc. 1986. MRID No. 0015992. Available from EPA. Write to FOI, EPA, Washington, DC 20460. ATSDR Reference Chapin RE, Harris MW, Davis BJ, et al. 1997. The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Fundam Appl Toxicol 40:138-157.

L90

An uncertainty factor of 100 was used to account for the inter-and intraspecies differences. An additional UF of 10 was used to account for the poor quality of the critical study and for the incompleteness of the database on chronic toxicity.

M90

10 for use of a LOAEL. 10 for extrapolation from animals to humans, and 10 for human variability

C91

LOAEL: 71.6 mg/kg/day

G91

Murata Y, Denda A, Maruyama H, et al. 1993. Chronic toxicity and carcinogenicity studies of 1-methynaphthalene in B6C3F1 mice. Fundam Appl Toxicol 21:44-51.

L91

10 for use of LOAEL, 10 for extrapolation from animals to humans, & 10 for human variability

A92


C92

NOAEL: 100 mg/kg-day; 71 mg/kg-day (adjusted) LOAEL: 200 mg/kg-day; 142 mg/kg-day (adjusted)

G92

IRIS Oral RfD Principal Study Battelle's Columbus Laboratories (BCL). (1980a) Unpublished subchronic toxicity study: Naphthalene (C52904), Fischer 344 rats. Prepared by Battelle Laboratories under NTP Subcontract No. 76-34-106002.

L92

The duration-adjusted NOAEL for terminal body weight decrease (> 10% of control) in male rats from the BCL (1980a) 90-day gavage study, 71 mg/kg-day, was divided by an uncertainty factor of 3000 (10 to extrapolate from rats to humans, 10 to protect sensitive humans, 10 to extrapolate from subchronic to chronic exposure, and 3 for database deficiencies including the lack of chronic oral exposure studies and 2-generation reproductive toxicity studies) to arrive at a chronic RfD for naphthalene of 2E-2 mg/kg-day.

A93


C93

LOAEL: 25 mg/cu.m (mice) converted to 4.6 mg/kg/day

G93

IRIS Oral RfD Principal Study CIIT (Chemical Industry Institute of Toxicology). 1984. Ninety-day inhalation toxicity study of nitrobenzene in F344 rats and B6C3F1 mice. Research Triangle Park, NC. FYI-OTS-0874-0333.

L93

The uncertainty factor of 10,000 represents two 10-fold factors for both intra- and interspecies variability to the toxicity of this chemical in lieu of specific data, a 10-fold factor for estimating a chronic effect level, from its subchronic equivalent, and a 10-fold factor for estimating an RfD from a LOAEL rather than a NOAEL.

A94


A95


C95


G95

IRIS Oral RfD Principal Studies U.S. EPA. 1986. o, m, p-Cresol. 90-Day oral subchronic toxicity studies in rats. Office of Solid Waste, Washington, DC. U.S. EPA. 1987. o, m, p-Cresol. 90-Day oral subchronic neurotoxicity study in rats. Office of Solid Waste, Washington, DC.

L95

10 for interspecies and 10 for intraspecies variability and 10 for uncertainty in extrapolat1on of subchronic data to levels of chronic effects.

A97


G97

HEAST reference #010516 CMA (Chemical Manufacturers' Association). 1988. Developmental Toxicity Evaluation Of O-, M-, Or P-Cresol Administered By Gavage To New Zealand White Rabbits. Final Project Report 51-508. Fiche NO. )TS0517695. Deitz D. And LT Mulligan. 1988. Subchronic Toxicity of P-Cresol In Sprague-Dawley Rats: MBA Chemical NO 25. Prepared By Research Triangle Institute. Research Triangle Park, NC. Preapared For EPA, Washington, DC. US EPA. 1993. RfD/RfC Work Group.

A98


C98

NOAEL: 3 mg/kg/day LOAEL: 10 mg/kg/day LOAEL: 1 mg/kg/day (ATSDR)

G98

IRIS Oral RfD Principal Study Schwetz, B.A., J.F. Quast, P.A. Keelev, C.G. Humiston and R.J. Kociba. 1978. Results of 2-year toxicity and reproduction studies on pentachlorophenol in rats. In: Pentachlorophenol: Chemistry, Pharmacology and Environmental Toxicology, K.R. Rao, Ed. Plenum Press, NY. p. 301. ATSDR Reference Beard AP, McRae AC, Rawlings NC. 1997. Reproductive efficiency in mink (mustela vison) treated with the pesticides lindane, carbofuran and pentachlorophenol. J Reprod Fertil 111:21-28.

L98

The 100-fold factor accounts for the expected intra- and interspecies variability to the toxicity of this chemical in lieu of specific data.

M98

10 to account for the use of a LOAEL, 10 for interspecies extrapolation, and 10 for humanvariability).

A99


C99


G99

IRIS Oral RfD Principal Study Argus Research Laboratories. (1997) Oral (gavage) developmental toxicity study of phenol in rats. Horsham, PA. Protocol number: 916-011. HEAST reference #005824 NTP (National Toxicology Program). (1983a). Teratologic evaluation of phenol in CD rats. Prepared by Research Triangle Institute, Research Triangle Park, NC. NTIS PB83-247726. Govt Rep Anounce Index, 83(25): 6247. US EPA. 1989. Updated Health Effects Assessment For Phenol. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC. US EPA. 1989. RfD/RfC Work Group.

L99

A composite uncertainty factor of 300 was used, based on default factors of 10 each for interspecies extrapolation and intraspecies variability and a database factor of 3 to account for uncertainties regarding the immunotoxic potential of phenol.

A100


C100

LOAEL: 0.005 mg/kg-day

G100

IRIS Oral RfD Principal Studies Arnold, D.L., F. Bryce, R. Stapley et al. 1993a. Toxicological consequences of Aroclor 1254 ingestion by female Rhesus (Macaca mulatta) monkeys, Part 1A: Prebreeding phase - clinical health findings. Food Chem. Toxicol. 31: 799- 810. Arnold, D.L., F. Bryce, K. Karpinski et al. 1993b. Toxicological consequences of Aroclor 1254 ingestion by female Rhesus (Macaca mulatta) monkeys, Part 1B: Prebreeding phase -clinical and analytical laboratory findings. Food Chem. Toxicol. 31: 811-824. Tryphonas, H., S. Hayward, L. O'Grady et al. 1989. Immunotoxicity studies of PCB (Aroclor 1254) in the adult rhesus (Macaca mulatta) monkey -- preliminary report. Int. J. Immunopharmacol. 11: 199-206. Tryphonas, H., M.I. Luster, G. Schiffman et al. 1991a. Effect of chronic exposure of PCB (Aroclor 1254) on specific and nonspecific immune parameters in the rhesus (Macaca mulatta) monkey. Fund. Appl. Toxicol. 16(4): 773-786. Tryphonas, H., M.I. Luster, K.L. White et al. 1991b. Effects of PCB (Aroclor 1254) on non-specific immune parameters in Rhesus (Macaca mulatta) monkeys. Int. J. Immunopharmacol. 13: 639-648.

L100

A 10-fold factor is applied to account for sensitive individuals. A factor of 3 is applied to extrapolation from rhesus monkeys to humans. A full 10-fold factor for interspecies extrapolation is not considered necessary because of similarities in toxic responses and metabolism of PCBs between monkeys and humans and the general physiologic similarity between these species. A partial factor is applied for the use of a minimal LOAEL since the changes in the periocular tissues and nail bed see at the 0.05 mg/kg-day are not considered to be of marked severity. The duration of the critical study continued for approximately 25% of the lifespan of rhesus monkeys so that a reduced factor was used for extrapolation from subchronic exposure to a chronic RfD. The immunologic and clinical changes that were observed did not appear to be dependent upon duration which further justifies using a factor of 3 rather than 10 for extrapolation from subchronic to chronic, lifetime exposure. The total UF is 300.

A101


C101


G101

IRIS Oral RfD Principal Study U.S. EPA. 1989. Mouse Oral Subchronic Toxicity of Pyrene. Study conducted by Toxicity Research Laboratories, Muskegon, MI for the Office of Solid Waste, Washington, DC.

L101

An uncertainty factor of 3000 reflects 10 each for intra- and interspecies variability, 10 for the use of a subchronic study for chronic RfD derivation, and an additional 3 to account for the lack of both toxicity studies in a second species and developmental/reproductive studies.

A102


C102


G102

IRIS Oral RfD Principal Study U.S. EPA. 1986. Pyridine. 90-Day subchronic oral toxicity in rats. Sponsored by Office of Solid Waste, Washington, DC.

L102

The UF of 1000 includes 10 for interspecies and 10 for intraspecies variability in the toxicity of this chemical in lieu of specific data. An additional factor of 10 was applied to extrapolate from a subchronic to chronic effect level.

Silvex (2,4,5-T) 93-72-1 NOAEL/LOAEL medium histopathologic changes 1 Gehring and Betso 1978 oral bioassay dog liver 100 100Toxaphene 8001-35-2 NOAEL Chu et al. 1986 dietary rat 100Trichlorophenol, 2,4,5 - 95-95-4 NOEL/LOAEL low pathology 1 McCollister et al. 1961 diet, subchronic rat liver, kidney 1000Trichlorophenol, 2,4,6 - 88-06-2Trimethylbenzene, 1,2,4 95-63-6 NOAEL low dec in body wt gain; clinical observations; inc liver/kidney wt 1 IITRI 1995 rat 3000Trimethylbenzene, 1,3,5 108-67-8 NOAEL low dec in body wt gain; clinical observations; inc liver/kidney wt 1 IITRI 1995 rat body 3000Trinitrobenzene, 1,3,5 - (s) 99-35-4 NOAEL/LOAEL medium methoglobinemia and spleen-erythroid cell hyperplasia; increased weight 1 Reddy et al. 1997 dietary; water rat spleen 100 1000Vinyl Acetate 108-05-4 NOAEL Altered weight 1 U.S. EPA 1989 water rat whole body, kidney 100 100

Inorganic AnalytesAntimony 7440-36-0 LOAEL low longevity, blood glucose and chloesterol 1 Schroeder et al. 1970 drinking water rat 1000Arsenic, Inorganic 7440-38-2 NOAEL/LOAEL medium hyperpigmentation, keratosis and possible vascular complications 1 Tseng 1977 drinking water human skin 3 3Barium and Compounds 7440-39-3 BMDL-05 /NOAEL medium nephropathy, increased blood pressure 1 NTP 1994 water mice, human kidney, cardiovascular system 300 3Beryllium and Compounds 7440-41-7 BMD low to medium lesions 1 Morgareidge et al. 1976 dietary dog small intestine 300Cadmium 7440-43-9 NOAEL high significant proteinuria 1 U.S. EPA 1985 diet, drinking water human 10Chromium (III) (insoluble salts) 16065-83-1 NOAEL low none observed 10 Ivankovic and Preussman 1975 chronic feeding study rat 100 1000Chromium (VI) 18540-29-9 NOAEL low none observed 3 MacKenzie et al. 1958 drinking water rat 300 100Cobalt and Compounds 7440-48-4 LOAEL low to medium polycythemia 1 Duckham and Lee 1976 human 10Cyanide, Free 57-12-5 NOAEL/LOAEL medium weight loss, thyroid effects, myelin degeneration 5 U.S. EPA 1979 diet, bioassay rat whole body, thyroid, nervous system 100 500Fluorine (soluble fluoride) 7782-41-4 NOAEL/LOAEL high objectionable dental fluorosis (cosmetic) 1 Hodge 1950 drinking water human teeth 1 1Mercury (elemental) 7439-97-6Methyl Mercury 22967-92-6 BMD medium developmental neurologic abnormalities in infants (developmetal neuropsychological impairment) 1 National Research Council 1991 epidemiological studies human central nervous system 10 10Nickel (Soluble Salts) 7440-02-0 NOAEL/LOAEL medium decreased body and organ weight 1 Ambrose et al. 1976 chronic, diet rat whole body, major organs 300 300Selenium and Compounds 7782-49-2 NOAEL/LOAEL high clinical selenosis 1 Yang et al. 1989 diet, epidemiological study human whole body 3 3Silver 7440-22-4 LOAEL low argyria 1 Gaul and Staud 1935 IV study human skin 3 3Thallium Carbonate 6533-73-9 NOAEL low increased levels of SGOT and LDH, alopecia 1 U.S. EPA 1986 subchronic, gavage rat liver, blood, hair 3000Thallium Chloride 7791-12-0 NOAEL low increased levels of SGOT and LDH, alopecia 1 U.S. EPA 1986 subchronic, gavage rat liver, blood, hair 3000Thallium Sulfate 7446-18-6 NOAEL low none observed 1 U.S. EPA 1986 subchronic, gavage rat 3000Vanadium Pentoxide 1314-62-1 NOAEL low decreased hair cystine 1 Stokinger et al. 1953 rat 100Vanadium, Metallic 7440-62-2 NOAEL 1 U.S. EPA 1987 drinking water rat 100 100Zinc and Compounds 7440-66-6 LOAEL medium decrease in erythrocyte Cu, Zn-superoxide dismutase (ESOD) activity (decreased blood enzyme) 1 Yadrick et al 1989 diet supplement human blood 3 3

Supplemental Criteria2-methylnaphthalene 91-57-6 BMD/BMDL low pulmonary alveolar proteinosis 1 Murata et al. 1997 dietary mouse respiratory system 1000 10004-chlorotoluene 106-43-4 NOAEL/LOAEL low decrease in body weight gain 1 Gibson et al. 1974a gavage rat whole body 1000 100Acenaphthylene 208-96-8 NOAEL/LOAEL low hepatotoxicity 1 U.S. EPA 1989 gavage mouse liver 3000 300Benzo(g,h,i)perylene 191-24-2 LOAEL medium Ocular exudate, inflamed Meibomian glands, distorted growth of nails; decreased antibody response to erythrocytes 1 Arnold et al. 1994 gelatin capsule, clinical, immunological monkey 300 100Copper 7440-50-8 LOAEL gastro-intestinal irritation US EPA 1987 oral human gastro-intestinal systemDimethyl phthalate 131-11-3 NOAEL/LOAEL medium Hematologic, hepatic and renal toxicity 1 Dow Chemical Co. 1983 bioassay, diet rat blood, liver, kidney 100 100Methyl butyl ketone 591-78-6 NOAEL Lethargy, increased absolute and relative organ weights, increased urinary protein levels 1 U.S. EPA 1993 subchronic, gavage rat whole body, liver, kidney 3000 300n-butyl benzene 104-51-8 BMDL medium increased weight 1 NTP 1990 inhalation ;gavage, subchronic rat kidney, liver 3000 100n-propyl benzene 103-65-1 NOEL low none observed; pathology, lesions 1 Nor-Am Agricultural Products, Inc. 1972 capsule; gavage dog; rat kidney 1000 100Phenanthrene 85-01-8 NOEL low none observed 1 U.S. EPA 1989 gavage mouse 3000 300p-isopropyltoluene (Cymene) 99-87-6 NOAEL medium decreased body weight, increased mortality 1 NTP 1986 chronic gavage exposure rat whole body 1000Sec-butyl benzene 135-98-8 BMDL medium increased weight 1 NTP 1990 inhalation ;gavage, subchronic rat kidney, liver 3000 100Tert-butyl benzene 98-06-6 BMDL medium increased weight 1 NTP 1990 inhalation ;gavage, subchronic rat kidney, liver 3000 100

A103


C103

NOEL: 30 ppm in diet (0.75 mg/kg/day) LOAEL: 100 ppm in diet (2.5 mg/kg/day)

G103

IRIS Oral RfD Principal Study Gehring, P.J. and J.E. Betso. 1978. Phenoxy acids: Effects and fate in mammals. In: Chlorinated Phenoxy Acids and Their Dioxins, Vol. 27, C. Ramel, Ed. Ecol. Bull., Stockholm. p. 122-133. Mullison, W.R. 1966. Some toxicological aspects of silvex. In: Proc. 19th Ann. Meet., Southern Weed Science Society, Raleigh, NC p. 420-435. HEAST reference #010284 Gehring, P.J. and J.E. Betso. 1978. Phenoxy acids: Effects and fate in mammals. In: Chlorinated Phenoxy Acids and Their Dioxins, Vol. 27, C. Ramel, Ed. Ecol. Bull., Stockholm. p. 122-133. Mullison, W.R. 1966. Some toxicological aspects of silvex. In: Proc. 19th Ann. Meet., Southern Weed Science Society, Raleigh, NC p. 420-435. US EPA. 1988. RfD/RfC Work Group.

L103

The UF of 100 includes a factor of 10 each for uncertainty of interspecies conversion and to protect sensitive individuals.

A104


C104

NOAEL: 0.35 mg/kg/day

G104

Chu I, Villeneuve DC, Sun CW, et al. 1986. Toxicity of toxaphene in the rat and beagle dog. Fund Appl Toxicol 7:406-418.

M104

10 for extrapolation from animals to humans & 10 for human variability

A105


C105

NOEL: 100 mg/kg/day (1000 ppm) LOAEL: 300 mg/kg/day (3000 ppm)

G105

IRIS Oral RfD Principal Study McCollister, D.D., D.T. Lockwood and V.K. Rowe. 1961. Toxicologic information on 2,4,5-trichlorophenol. Toxicol. Appl. Pharmacol. 3: 63-70.

L105

The uncertainty factor of 1000 reflects 10 for both intraspecies and interspecies variability to the toxicity of this chemical in lieu of specific data, and 10 for extrapolation of a subchronic effect level to its chronic equivalent.

A106


A107


A108


A109


C109

NOAEL: 2.68 mg/kg-day LOAEL:13.31 mg/kg-day

G109

IRIS Oral RfD Principal Studies Reddy, T.V., F.B. Daniel, G.R. Olson, B. Wiechman and G. Reddy. 1996. Chronic toxicity studies of 1,3,5-trinitrobenzene in Fischer 344 rats. U.S. Army, Fort Detrick, MD. (Final Report) Reddy, G., T.V. Reddy, H. Choudhury, F.B. Daniel and G. Leach. 1997. Assessments of environmental Hazards of 1,3,5-trinitrobenzene (TNB). J. Toxicol.Environ. Health 52:101-114. HEAST reference #010081 Cody TE, S Wintherup, L Hastings, K Stemmer, And RT Chustion. 1981. 1,3-Dinitrobenzene: Toxic Effects In Vitro. J Toxic0l Environ Health. 7: 829-847. US EPA Health And Environmental Effects Document For For 1,3,5- Trinitrobenzene. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergency Response, Washington, DC. US EPA. 1988. RfD/RfC Work Group.

L109

100. Ten for inter- and 10 for intra-species extrapolation.

A110


C110


G110

HEAST reference #010417 US EPA. 1989. Health And Environmental Effects Document For Vinyl Acetate. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergemcy Response, Washington DC.

A112


C112

LOAEL: 0.35 mg/kg bw/day

G112

IRIS Oral RfD Principal Study Schroeder, H.A., M. Mitchner and A.P. Nasor. 1970. Zirconium, niobium, antimony, vanadium and lead in rats: Life term studies. J. Nutr. 100(1): 59-68.

A113


C113

NOAEL: 0.009 mg/L converted to 0.0008 mg/kg-day LOAEL: 0.17 mg/L converted to 0.014 mg/kg-day

G113

IRIS Oral RfD Principal Studies Tseng, W.P. 1977. Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic. Environ. Health Perspect. 19: 109-119. Tseng, W.P., H.M. Chu, S.W. How, J.M. Fong, C.S. Lin and S. Yeh. 1968. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J. Natl. Can0cer. Inst. 40(3): 453-463. HEAST reference# 010963 Tseng, W.P. 1977. Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic. Environ. Health Perspect. 19: 109-119. Tseng, W.P., H.M. Chu, S.W. How, J.M. Fong, C.S. Lin and S. Yeh. 1968. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J. Natl. Can0cer. Inst. 40(3): 453-463. US EPA. 1990. RfD/RfC Work Group.

L113

The UF of 3 is to account for both the lack of data to preclude reproductive toxicity as a critical effect and to account for some uncertainty in whether the NOAEL of the critical study accounts for all sensitive individuals.

A114


C114

BMDL05: 63 mg/kg-day NOAEL: 0.21 mg/kg/day

G114

IRIS Oral RfD Principal Study National Toxicology Program (NTP), Public Health Service, U.S. Department of Health and Human Services. (1994) NTP technical report on the toxicology and carcinogenesis studies of barium chloride dihydrate (CAS no. 10326-27-9) in F344/N rats and B6C3F1 mice (drinking water studies). NTP TR 432. Research Triangle Park, NC. NIH pub. no. 94-3163. NTIS pub PB94-214178. HEAST reference #010348 Wones, RG, BL Stadler, LA Frohman. 1990. Lack Of Effect Of Drinking Water Barium On Cardiovascular Risk Factor. Environ Health Perspect. 85: 1-13. Brenniman, GR, PS Levi. 1984. High Barium Levels In Pablic Drinking Water And Its Association With Elevated Blood Pressure. IN: Advances In Modern Toxicology IX. EJ Calalbrese, Ed. Princeton Scientific Publications, NJ. p 231-249. US EPA. 1985. Drinking Water Criteria Document For Barium. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Drinking Water, Washington, DC. EXT Review Draft. Final Draft (On Public Comment). NTIS PB 86-118031/AS. US EPA. 1990. RfD/RfC Work Group.

L114

A total UF of 300 was applied: 10 for extrapolation for interspecies differences (UFA: animal to human); 10 for consideration of intraspecies variation (UFH: human variability); and 3 for deficiencies in the database (UFD).

A115


C115

BMD10: 0.46 mg/kg-day

G115

IRIS Oral RfD Principal Study Morgareidge, K; Cox, GE; Gallo, MA. (1976) Chronic feeding studies with beryllium in dogs. Food and Drug Research Laboratories, Inc. Submitted to the Aluminum Company of America, Alcan Research & Development, Ltd., Kawecki-Berylco Industries, Inc., and Brush-Wellman, Inc.

A116


C116

NOAEL (water): 0.005 mg/kg/day NOAEL (food): 0.01 mg/kg/day

G116

IRIS Oral RfD Principal Study U.S. EPA. 1985. Drinking Water Criteria Document on Cadmium. Office of Drinking Water, Washington, DC. (Final draft).

L116

This uncertainty factor is used to account for intrahuman variability to the toxicity of this chemical in the absence of specific data on sensitive individuals.

A117


C117

NOAEL: 5% Cr2O3 in diet 5days/week for 600 feedings (1,800 g/kg bw average total dose) NOAEL(ADJ): 1,468 mg/kg-day

F117

An additional 10-fold modifying factor is applied to reflect database deficiencies including the lack of a study in a nonrodent mammal, lack of unequivocal data evaluating reproductive impacts, and the concern regarding potential reproductive effects raised by the study of Elbetieha and Al-Hamood (1997). The value of the modifying factor has not been changed from the previous IRIS entry. The study of Elbetieha and Al-Hamood (1997) provides strong support for the use of a 10-fold modifying factor to reflect uncertainty regarding potential reproductive effects of Cr(III). The following additional uncertainties relate to the NOAEL derived from the Ivankovic and Preussman (1975) study: 1) the effects observed in the 90-day study were not explicitly addressed in the 2-year study; 2) the effect of the vehicle (baked bread) on absorption of chromium is uncertain, and the relevance of this dosing regimen to exposures in the environment is unclear; 3) animals were allowed to die naturally after feeding stopped (2 years) and only then was histology performed. Application of the 100-fold uncertainty factor and 10-fold modifying factor to the adjusted NOAEL of 1,468 mg/kg-day gives the reference dose of 1.5 mg/kg-day.

G117

IRIS Oral RfD Principal Study Ivankovic, S; Preussmann, R. (1975) Absence of toxic and carcinogenic effects after administration of high doses of chromic oxide pigment in subacute and long-term feeding experiments in rats. Food Cosmet Toxicol 13:347-351. HEAST reference #005731 Ivankovic, S; Preussmann, R. (1975) Absence of toxic and carcinogenic effects after administration of high doses of chromic oxide pigment in subacute and long-term feeding experiments in rats. Food Cosmet Toxicol 13:347-351. US EPA. 1984. Health Effects Assessment For Trivalent Chromium. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergemcy And Remedial Response, Washington, DC. US EPA. 1986. RfD/RfC Work Group.

L117

The factor of 100 represents two 10-fold decreases in mg/kg bw-day dose that account for both the expected interhuman and interspecies variability to the toxicity of the chemical in lieu of specific data.

A118


C118

NOAEL: 25 mg/L of chromium as K2CrO4 2.5 mg/kg-day (adj.)

G118

IRIS Oral RfD Principal Study MacKenzie, RD; Byerrum, RU; Decker, CF, et al. (1958) Chronic toxicity studies. II. Hexavalent and trivalent chromium administered in drinking water to rats. Am Med Assoc Arch Ind Health 18:232-234. HEAST reference #005522 MacKenzie, RD; Byerrum, RU; Decker, CF, et al. (1958) Chronic toxicity studies. II. Hexavalent and trivalent chromium administered in drinking water to rats. Am Med Assoc Arch Ind Health 18:232-234. US EPA. 1984. Health Effects Assessment For Hexavalent Chromium. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC. US EPA. 1986. RfD/RfC Work Group.

L118

The uncertainty factor of 300 represents two 10-fold decreases in dose to account for both the expected interhuman and interspecies variability in the toxicity of the chemical in lieu of specific data, and an additional factor of 3 to compensate for the less-than-lifetime exposure duration of the principal study.

A120


C120


F120

A modifying factor of 5 is used to account for the apparent tolerance to cyanide when it is ingested with food rather than when it is administered by gavage or by drinking water.

G120

IRIS Oral RfD Principal Studies Howard, J.W. and R.F. Hanzal. 1955. Chronic toxicity to rats of food treated with hydrogen cyanide. J. Agric. Food Chem. 3: 325-329. Philbrick, D.J., J.B. Hopkins, D.C. Hill, J.C. Alexander and R.G. Thomson. 1979. Effects of prolonged cyanide and thiocyanate feeding in rats. J. Toxicol. Environ. Health. 5: 579-592. Hydrogen cyanide (HCN) is soluble in water and dilute acid (which includes the gastric environment) and is readily hydrolyzed to 1 molar equivalent of cyanide (CN) and 1 molar equivalent of hydrogen (Hartung, 1982). HEAST reference #005396 Howard, J.W. and R.F. Hanzal. 1955. Chronic toxicity to rats of food treated with hydrogen cyanide. J. Agric. Food Chem. 3: 325-329. US EPA. 1984. Health Effects Assessment For Cyanide. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC. US EPA. 1991. Drinking Water Criteria Document For Cyanide. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Drinking Water, Washington, DC. US EPA. 1985. RfD/RfC Work Group.

L120

According to the U.S. EPA (1985), an uncertainty factor of 100 is used to derive the RfD (10 for species extrapolation, 10 for sensitive population).

A121


C121

NOAEL: 1 ppm (converted 0.06 mg/kg/day LOAEL: 2 ppm

G121

IRIS Oral RfD Principal Study Hodge, H.C. 1950. The concentration of fluorides in drinking water to give the point of minimum caries with maximum safety. J. Am. Dent. Assoc. 40: 436. Cited in: Underwood, E.J. 1977. Trace Elements in Human and Animal Nutrition. Academic Press, NY. HEAST reference #005965 Hodge, H.C. 1950. The concentration of fluorides in drinking water to give the point of minimum caries with maximum safety. J. Am. Dent. Assoc. 40: 436. Cited in: Underwood, E.J. 1977. Trace Elements in Human and Animal Nutrition. Academic Press, NY. US EPA. 1989. Health And Environmental Effects Document For Fluoride. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste Adn Emergency Response, Washington, DC. US EPA. 1986. RfD/RfC Work Group.

L121

Uncertainty factors were not deemed necessary since the NOAEL is that of the critical effect (i.e., dental fluorosis) in a sensitive population of humans (i.e., children) for a length of exposure that encompasses both the critical effect and the sensitive population.

A122


C123

Benchmark Dose: BMDL05 range of 46–79 ppb in maternal blood for different neuropsychological effects in the offspring at 7 years of age, corresponding to a range of maternal daily intakes of 0.857–1.472 µg/kg-day

G123

IRIS Oral RfD Principal Study And Supporting Studies National Research Council (NRC). (2000) Toxicological effects of methylmercury. Committee on the Toxicological Effects of Methylmercury, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council. Washington, DC: National Academy Press. Grandjean, P; Weihe, P; White, R; et al. (1997) Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 20:1-12. Budtz-Jørgensen, E; Keiding, N; Grandjean, P; et al. (1999a) Methylmercury neurotoxicity independent of PCB exposure. [Letter]. Environ Health Perspect 107(5):A236-237. HEAST reference #010970 Marsh, DO; Clarkson, TW; Cox, C; et al. (1987) Fetal methylmercury poisoning: relationship between concentration in single strands of maternal-hair and child effects. Arch Neurol 44:1017-1022. Seafood Safety. 1991. Committee On Evaluation Of The Safety Of Fishery Products. Chapter On Methylmercury: FDA Risk Assessment And Current Regulations. National Academy Press, Washington, DC. P. 196-221. U.S. EPA. (1980) Ambient Water Quality Criteria Document for Mercury. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulation and Standards, Washington, DC. EPA/440/5-80/058. NTIS PB 81-117699. U.S. EPA. (1995) Mercury Study Report to Congress. Office of Research and Development, Washington, DC. External Review Draft. EPA/600/P-94/002Ab. US EPA. 1994. RfD/RfC Work Group.

L123

In calculating the methylmercury RfD for this assessment, a composite UF of 10 was used. This choice was made to account for the following factors: 1). Pharmacokinetic variability and uncertainty in estimating an ingested mercury dose from cord-blood mercury concentration: a factor of 3 was applied. 2). Pharmacodynamic variability and uncertainty: a factor of 3 was applied.

A124


C124

NOAEL: 100 ppm diet (5 mg/kg/day) LOAEL: 1000 ppm diet (50 mg/kg/day)

G124

IRIS Oral RfD Principal And Supporting Studies Ambrose, A.M., D.S. Larson, J.R. Borzelleca and G.R. Hennigar, Jr. 1976. Long-term toxicologic assessment of nickel in rats and dogs. J. Food Sci. Technol. 13: 181-187. ABC (American Biogenics Corp.). 1986. Ninety-day gavage study in albino rats using nickel. Draft Final Report submitted to Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709. HEAST reference #005579 Ambrose, A.M., D.S. Larson, J.R. Borzelleca and G.R. Hennigar, Jr. 1976. Long-term toxicologic assessment of nickel in rats and dogs. J. Food Sci. Technol. 13: 181-187. US EPA. 1991. Drinking Water Quantification Of Toxicologic Effects For Nickel. Prepared By Environmental Criteria And Assessment Office, Office Of Health And Environmental Assessment, Cincinnati, OH For The Office Of Water, Washington, DC. US EPA. 1991. RfD/RfC Work Group.

L124

An uncertainty factor of 10 is used for interspecies extrapolation and 10 to protect sensitive populations. An additional uncertainty factor of 3 is used to account for inadequacies in the reproductive studies (RTI, 1987; Ambrose et al., 1976; Smith et al., 1990). During the gestation and postnatal development of F1b litters in the RTI (1987) study, temperatures were about 10 degrees F higher than normal at certain times, which makes evaluation of this part of the reproductive study impossible. In the Ambrose et al. (1976) study, statistical design limitations included small sample size and use of pups rather than litters as the unit for comparison. There were also problems with the statistical analysis of the Smith et al. (1990) study.

A125


C125


G125

IRIS Oral RfD Principal Study Yang, G., S. Yin, R. Zhou, et al. 1989b. Studies of safe maximal daily dietary Se-intake in a seleniferous area in China. II. Relation between Se- intake and the manifestation of clinical signs and certain biochemical alterations in blood and urine. J. Trace Elem. Electrolytes Health Dis. 3(2): 123-130. HEAST reference #010404 Yang, G., S. Yin, R. Zhou, et al. 1989b. Studies of safe maximal daily dietary Se-intake in a seleniferous area in China. II. Relation between Se- intake and the manifestation of clinical signs and certain biochemical alterations in blood and urine. J. Trace Elem. Electrolytes Health Dis. 3(2): 123-130. U.S. EPA. 1989. Health Effects Assessment for Selenium (and Compounds). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC. US EPA. 1991. RfD/RfC Work Group.

L125

An uncertainty factor of 3 was applied to the NOAEL to account for sensitive individuals. A full factor of 10 was not deemed necessary since similar NOAELs were identified in two moderately-sized human populations exposed to selenium levels in excess of the RDA throughout a lifetime without apparent clinical signs of selenosis.

A126


C126

LOAEL: 1 g (total dose); converted to an oral dose of 0.014 mg/kg/day

G126

IRIS Oral RfD Principal Study Gaul, L.E. and A.H. Staud. 1935. Clinical spectroscopy. Seventy cases of generalized argyrosis following organic and colloidal silver medication. J. Am. Med. Assoc. 104: 1387-1390. HEAST reference #010453 Gaul, L.E. and A.H. Staud. 1935. Clinical spectroscopy. Seventy cases of generalized argyrosis following organic and colloidal silver medication. J. Am. Med. Assoc. 104: 1387-1390. Blumberg, H. and T.N. Carey. 1934. Argyremia: Detection of unsuspected and obscure argyria by the spectrographic demonstration of high blood silver. J. Am. Med. Assoc. 103(20): 1521-1524. East, B.W., K. Boddy, E.D. Williams, D. MacIntyre and A.L.C. McLay. 1980. Silver retention, total body silver and tissue silver concentrations in argyria associated with exposure to an anti-smoking remedy containing silver acetate. Clin. Exp. Dermatol. 5: 305-311.

L126

An uncertainty factor of 3 is applied to account for minimal effects in a subpopulation which has exhibited an increased propensity for the development of argyria. The critical effect observed is a cosmetic effect, with no associated adverse health effects. Also, the critical study reports on only 1 individual who developed argyria following an i.v. dose of 1 g silver (4 g silver arsphenamine). Other individuals did not respond until levels five times higher were administered. No uncertainty factor for less than chronic to chronic duration is needed because the dose has been apportioned over a lifetime of 70 years.

C127

NOAEL: 0.25 mg/kg/day (Tl2SO4) (converted to 0.23 mg/kg/day Tl2CO3)

G127

IRIS Oral RfD Principal Study U.S. EPA. 1986. Subchronic (90-day) toxicity of thallium sulfate in Sprague- Dawley rats. Office of Solid Waste, Washington, DC.

L127

The UF of 3000 includes factors of 10 to extrapolate from subchronic to chronic data, 10 for intraspecies extrapolation and 10 to account for interspecies variability, and a factor of 3 to account for lack of reproductive and chronic toxicity data.

C128

NOAEL: 0.25 mg/kg/day Tl2SO4 (converted to 0.23 mg/kg/day TlCl)

G128


L128


C129

NOAEL: 0.25 mg/kg/day

G129


L129


C131

NOAEL: 5 ppm

G131

HEAST reference #005739 Schroeder, HA, M Mitcherner, And AP Nason. 1970. Zirconium, Niobium, Antimony, And Lead In Rats: Life-Time Studies. J Nutr 100:59-69. US EPA. 1987. Health Effects Assessment For Vanadium And Compounds. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A132


C132


G132

IRIS Oral RfD Principal Studies Yadrick, MK; Kenney, MA; Winterfeldt, EA. (1989) Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr 49:145-150. Fischer, PW; Giroux, A; L'Abbe, MR. (1984) Effect of zinc supplementation on copper status in adult man. Am J Clin Nutr 40:743-746. Davis, CD; Milne, DB; Nielsen, FH. (2000) Changes in dietary zinc and copper affect zinc-status indicators of postmenopausal women, notably, extracellular superoxide dismutase and amyloid precursor proteins. Am J Clin Nutr 71:781-788. Milne, DB; Davis, CD; Nielsen, FH. (2001) Low dietary zinc alters indices of copper function and status in postmenopausal women. Nutrition 17:701-708. HEAST reference #010937 Yadrick, MK; Kenney, MA; Winterfeldt, EA. (1989) Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr 49:145-150. US EPA. 1991. RfD/RfC Work Group.

L132

A threefold intraspecies uncertainty factor (UFH) was used to account for variability in susceptibility in human populations.

C134

BMD05: 4.7 mg/kg-day BMDL05: 3.5 mg/kg-day

G134

IRIS Oral RfD Principal Study Murata, Y; Denda, A; Maruyama, H; et al. (1997) Short communication. Chronic toxicity and carcinogenicity studies of 2-methylnaphthalene in B6C3F1 mice. Fundam Appl Toxicol 36:90-93.

L134

UF = 1000. A total uncertainty factor of 1000 was applied to the BMDL05 of 4.7 mg/kg-day: 10 for extrapolation for interspecies differences (UFA: animal to human); 10 for consideration of intraspecies variation (UFH: human variability); and 10 for deficiencies in the database (UFD).

G135

IRIS Oral RfD Principal Study for O-Chlorotoluene Gibson, W.R., F.O. Gossett, G.R. Koenig and F. Marroquin. 1974a. The toxicity of daily oral doses of o-chlorotoluene in the rat. Toxicology Division, Lilly Research Laboratories. Submitted to Test Rules Development Branch, Office of Toxic Substances, U.S. EPA, Washington, DC.

L135

An uncertainty factor of 1000 was used: 10 to account for interspecies extrapolation, 10 for differences in individual human sensitivity, and 10 for use of a subchronic study.

A136


C136


G136

IRIS Oral RfD Principal Study U.S. EPA. 1989. Mouse oral subchronic study with acenaphthene. Study conducted by Hazelton Laboratories, Inc., for the Office of Solid Waste, Washington, DC. HEAST reference #010165 U.S. EPA. 1989. Mouse oral subchronic study with acenaphthene. Study conducted by Hazelton Laboratories, Inc., for the Office of Solid Waste, Washington, DC. US EPA. 1989. RfD/RfC Work Group.

L136

An uncertainty factor of 3000 reflects 10 each for inter- and intraspecies variability, 10 for the use of a subchronic study for chronic RfD derivation, and 3 for the lack of adequate data in a second species and reproductive/developmental data.

A137


C137


G137

IRIS Oral RfD Principal Studies Arnold, D.L., F. Bryce, R. Stapley et al. 1993a. Toxicological consequences of Aroclor 1254 ingestion by female Rhesus (Macaca mulatta) monkeys, Part 1A: Prebreeding phase - clinical health findings. Food Chem. Toxicol. 31: 799- 810. Arnold, D.L., F. Bryce, K. Karpinski et al. 1993b. Toxicological consequences of Aroclor 1254 ingestion by female Rhesus (Macaca mulatta) monkeys, Part 1B: Prebreeding phase -clinical and analytical laboratory findings. Food Chem. Toxicol. 31: 811-824. Tryphonas, H., S. Hayward, L. O'Grady et al. 1989. Immunotoxicity studies of PCB (Aroclor 1254) in the adult rhesus (Macaca mulatta) monkey -- preliminary report. Int. J. Immunopharmacol. 11: 199-206. Tryphonas, H., M.I. Luster, G. Schiffman et al. 1991a. Effect of chronic exposure of PCB (Aroclor 1254) on specific and nonspecific immune parameters in the rhesus (Macaca mulatta) monkey. Fund. Appl. Toxicol. 16(4): 773-786. Tryphonas, H., M.I. Luster, K.L. White et al. 1991b. Effects of PCB (Aroclor 1254) on non-specific immune parameters in Rhesus (Macaca mulatta) monkeys. Int. J. Immunopharmacol. 13: 639-648.

L137

A 10-fold factor is applied to account for sensitive individuals. A factor of 3 is applied to extrapolation from rhesus monkeys to humans. A full 10-fold factor for interspecies extrapolation is not considered necessary because of similarities in toxic responses and metabolism of PCBs between monkeys and humans and the general physiologic similarity between these species. A partial factor is applied for the use of a minimal LOAEL since the changes in the periocular tissues and nail bed see at the 0.05 mg/kg-day are not considered to be of marked severity. The duration of the critical study continued for approximately 25% of the lifespan of rhesus monkeys so that a reduced factor was used for extrapolation from subchronic exposure to a chronic RfD. The immunologic and clinical changes that were observed did not appear to be dependent upon duration which further justifies using a factor of 3 rather than 10 for extrapolation from subchronic to chronic, lifetime exposure. The total UF is 300.

C138

LOAEL: 5.3 mg

G138

HEAST Reference #005374 US EPA. 1987. Drinking Water Criteria Documant For Copper. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Drinking Water, Washington, DC.

A139


C139


G139

IRIS Oral RfD Principal Study Dow Chemical Co. 1983. Acc. No. 251473. Available from EPA. Write to FOI, EPA, Washington, DC 20460. HEAST reference #01265 Dow Chemical Co. 1983. Acc. No. 251473. Available from EPA. Write to FOI, EPA, Washington, DC 20460. US EPA. 1988. RfD/RfC Work Group.

L139

The 100-fold uncertainty factor accounts for both interspecies and interhuman variability in the toxicity of this chemical in lieu of specific data. Because an analysis of the 90-day and 1-year interim results suggests that the NOAEL would hold for the full 2-year duration, inclusion of the subchronic-to-chronic UF is not warranted.

C140


G140

HEAST reference #010949 Microbiological Associates. 1986. Subchronic Toxicity Of Methyl Isobutyl Ketone In Sprague-Dawley Rats. Performed For Research Triangle Institute, PO Box 12194, Research Triangle Park, NC, 27709. Final Report. Study NO 522104. US EPA. 1993. RfD/RfC Work Group.

C141


G141

IRIS Oral RfD Principal Study NTP (National Toxicology Program). (1990) Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies). Public Health Service, U.S. Department of Health and Human Services; NTP TR 371. Available from: National Institute of Environmental Health Sciences, Research Triangle Park, NC. HEAST reference #010469 NTP (National Toxicology Program). (1990) Toxicology and carcinogenesis studies of toluene (CAS No. 108-88-3) in F344/N rats and B5C3F1 mice (inhalation studies). Public Health Service, U.S. Department of Health and Human Services; NTP TR 371. Available from: National Institute of Environmental Health Sciences, Research Triangle Park, NC. US EPA. 1984. Health Effects Assessment For Toluene. Prepared By The Office Of Health And Envrionmental Assessment, Environmental Criteria And Assesssment Office For The Office Of Emergency And Remedial Response, Washington, DC. US EPA. 1990. RfD/RfC Work Group.

L141


C142

NOEL: 150 mg/kg/day LEL: 250 mg/kg/day (179 mg/kg/day)

G142

IRIS Oral RfD Principal And Supporting Studies Nor-Am Agricultural Products, Inc. 1972a. MRID No. 00123976. Available from EPA. Write to FOI, EPA, Washington, DC 20460. Nor-Am Agricultural Products, Inc. 1972b. MRID No. 00123977. Available from EPA. Write to FOI, EPA, Washington DC. 20460. NTP (National Toxicology Program). 1984. NTP Technical Report on the Toxicology and Carcinogenisis Studies of Isophorone in F344/N Rats and B63F1 Mice (Gavage). NIH Publication No. 84-2547, NTP-83-168. HEAST reference #005910 Nor-Am Agricultural Products, Inc. 1972. MRID No. 00123976. Available from EPA. Write to FOI, EPA, Washington DC. 20460. NTP (National Toxicology Program). 1984. NTP Technical Report on the Toxicology and Carcinogenisis Studies of Isophorone in F344/N Rats and B63F1 Mice (Gavage). NIH Publication No. 84-2547, NTP-83-168. US EPA. 1993. Revised And Updated Drinking Water Quantification OF TOxicological Effects For Isophorone. Prepared By The Office Of Health And Environmental Assessment, Environemtnal Criteria And Assessment Office, Cincinnati, OH For The Office Of Water, Washington, DC. US EPA. 1989. RfD/RfC Work Group.

L142

An uncertainty factor of 100 was used to account for the inter- and intraspecies differences. An additional UF of 10 was used to account for the use of a subchronic study. (The use of the chronic study to estimate the RfD would not evoke this latter 10-fold factor, but would necessitate a 10-fold factor for the use of a LOAEL. In either case the RfD is the same.)

A143


C143

NOEL: 1000 mg/kg/day

G143

IRIS Oral RfD Principal Study U.S. EPA. 1989. Subchronic toxicity in mice with anthracene. Final Report. Hazelton Laboratories America, Inc. Prepared for the Office of Solid Waste, Washington, DC. HEAST reference #010166 US EPA. 1989. Subchronic Toxicity In Mice With Anthracene. Final Report. Hazelton Laboratories America, Inc. Prepared For The Office Of Solid Waste, Washinghton, DC. US EPA. 1991. Drinking Water Criteria Document For Anthracene. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Drinking Water, Washington, DC. US EPA. 1989. RfD/RfC Work Group. HEAST reference #010964 US EPA. 1994. RfD/RfC Work Group.

C144

NOAEL: 250 mg/kg-day (179 mg/kg-day)* LOAEL: 500 mg/kg-day

G144

IRIS Oral RfD Principal Study NTP (National Toxicology Program). (1986) NTP technical report on the toxicology and carcinogenesis of xylenes (mixed) (60% m-xylene, 13.6% p-xylene, 17.0% ethylbenzene, and 9.1% o-xylene) in F344/N rats and B6C3F1 mice (gavage studies). Research Triangle Park, NC. NTP TR 327, NIH Publ. No. 86-2583.

L144

A UF of 10 was applied to account for laboratory animal-to-human interspecies differences. No information is available to support a change from default. A UF of 10 was applied for intraspecies uncertainty to account for human variability and sensitive populations. This factor accounts for humans who may be more sensitive than the general population to exposure to xylenes. A UF of 10 was used to account for database uncertainty.

C145


G145


L145


C146


G146


L146


OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)INHALATION RfC TOXICITY METADATA FOR CHEMICALS OF CONCERN

Chemical CAS # RfC Basis RfC Confidence Level RfC Critical Effect RfC Modifying Factor RfC Study Reference RfC Study Date RfC Study Species RfC Target Organ Chronic RfC Uncertainty Factor Subchronic RfC UF

Volatile Organic CompoundsAcetone 67-64-1 LOAEL neurological effects Stewart et al. 1975 human nervous system 100 100Benzene 71-43-2 BMCL medium decreased lymphocyte count 1 Rothman et. al. 1996 human blood 300Carbon Disulfide 75-15-0 BMC medium peripheral dysfunction 1 Johnson et al. 1983 human nervous system 30 30Carbon Tetrachloride 56-23-5 LOAEL low toxicity Adams et al. 1952 guinea pig liver 3000 300Chlorobenzene 108-90-7 LED (10 HEC) low kidney and liver effects 1 Nair et al. 1987 rat liver 1000Chloroethane 75-00-3 NOAEL/LOAEL medium delayed fetal ossification / developmental toxicity 1 Scortichini et al. 1986 mouse fetus 300 300Chloroform 67-66-3 LOAEL hepatic effects; toxic hepatitis Bornski et al; Phoon et al 1967; 1983 human liverDibromochloromethane 124-48-1Dichlorodifluoromethane 75-71-8 LOAEL lesions 1 U.S. EPA 1997 guinea pig liver 10000 1000Dichloroethane, 1,1 - 75-34-3 NOEL damage 1 U.S. EPA 1997 cat kidney 1000 100Dichloroethane, 1,2 - 107-06-2 NOAEL/LOAEL liver histopathology; increased absolute and relative kidney weights Cheever et al; NTP 1990; 1991a rats liver; kidney 90Dichloroethene, 1,1 - 75-35-4 BMCL medium toxicity (fatty change) 1 Quast et al. 1986 rat liver 100

156-59-2156-60-5 LOAEL low pulmonary capillary hyperemia and distension of alveolar septum 1 Freundt et al. 1977 rat lung 3000

Dichloropropane, 1,2 - 78-87-5 NOAEL/LOAEL medium hyperplasia of the mucosa 1 Nitschke et al. 1988 rat nasal 300 100Dichloropropene, 1,3 - 542-75-6 BMCL/BMC; NOAEL high hypertrophy/hyperplasia of respiratory epithelium & mucosa 1 Lomax et al 1989 mouse nasal 30 30Dioxane, 1,4 - 123-91-1 NOAEL effects Torkelson et al. 1974 rats liver 30 30Ethyl Ether 60-29-7Ethylbenzene 100-41-4 NOAEL/LOAEL low developmental toxicity 1 Andrew et al. & Hardin et al. 1981 rat, rabbit 300Formaldehyde 50-00-0 NOAEL/LOAEL histological evidnece of mild damage to epithelial tissue; nasopharyngeal irritation & lesions in nasal epithelium Holmstrom et al; Rusch et al. 1989c; 1983 human; monkeys nasal 30 30Formic acid 64-18-6 NOAEL-HEC low nasal lesions 1 NTP 1992 mouse respiratory system 1000

110-54-3 BMCL (HEC) medium peripheral neuropathy 1 Huang; Sanagi et al. 1989 rat nervous system 300Isobutyl Alcohol 78-83-1Methanol 67-56-1 Cal/EPA developmentMethyl Ethyl Ketone (MEK) 78-93-3 LEC(HEC)/NOAEL medium developmental toxicity (skeletal variations); decreased birth weight 1 Schwetz et al. 1991 mouse fetus 300 3000Methyl Isobutyl Ketone (MIBK) 108-10-1 NOEL-HEC low/medium reduced fetal body weight, skeletal variations, increased fetal death; increased liver weight & kidney effects 1 Tyl et al. 1987 rat and mouse fetus; liver, kidney 300 100

1634-04-4 NOAEL/LOAEL medium increased absolute and relative weights, increased severity of lesions, prostration, swollen periocular tissue 1 Chun et al. 1992 rat liver, kidney, eyes 100Methylene Chloride 75-09-2 NOAEL/LOAEL liver effects (cytoplasmic vacuolization, fatty infiltration, multinicleated hepatocytes) 1 Nitschke et al.; Haun et al. 1988; 1972 rat liver 30 90Styrene 100-42-5 NOAEL/LOAEL medium Central nervous system effects 1 Mutti et al. 1984 human nervous system 30Tetrachloroethane , 1,1,1,2 - 630-20-6Tetrachloroethane, 1,1,2,2 - 79-34-5Tetrachloroethene 127-18-4 LOAEL increased reaction times 1 Ferroni et al. 1992 human 100Toluene 108-88-3 NOAEL high neurological effects 1 Foo et al. (multiple studies) '1990 (multiple studies)' human 10Trichloroethane, 1,1,1 - 71-55-6 NOAEL low to medium damage, injury 1 Rosengren t al. 1985 gerbil liver, brain 90Trichloroethane, 1,1,2 - 79-00-5Trichloroethene 79-01-6 LOAEL neurotoxicity Vandervort & Polnkoff 1973 human 100Trichlorofluoromethane 75-69-4 LOAEL increased BUN, lung inflammation 1 U.S. EPA 1987 dog kidney, lung 10000 1000Trichloropropane, 1,2,3 - 96-18-4Vinyl Chloride 75-01-4 NOAEL/LOAEL medium cell polymorphism 1 Til et al. 1991 rat liver 30Xylenes, Total 1330-20-7 NOAEL (HEC) Medium Impaired motor coordination (decreased rotarod performance) 1 Korsak et. al. 1994 male rat 300

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9Acetophenone 98-86-2Acrylonitrile 107-13-1 LOAEL medium degeneration and inflamation of epithelium, hyperlasia of mucous secreting cells 1 Quast 1980 rat nasal 1000Aniline 62-53-3 NOAEL/LOAEL low lack of toxicity; mild toxicity 1 Oberst; duPont 1956; 1982 rat, mouse, guinea pig spleen 3000Anthracene 120-12-7Benzidine 92-87-5Benzo(a)anthracene 56-55-3Benzo(a)pyrene 50-32-8Benzo(b)fluoranthene 205-99-2Benzo(k)fluoranthene 207-08-9Bis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7Butyl Benzyl Phthalate 85-68-7Carbazole 86-74-8Chlordane 57-74-9 NOAEL low hepatic effects 1 Khawawinah et al. 1989 rat liver 1000Chrysene 218-01-9Dibenz(a,h)anthracene 53-70-3Dichlorobenzene, 1,2 - (o) 95-50-1 NOEL decreased weight gain 1 U.S. EPA 1987 rat whole body 1000 100Dichlorobenzene, 1,4 - (p) 106-46-7 NOAEL/LOAEL medium increased liver weight in males 1 Chlorobenzene Producers Assn. 1986 rat liver 100Dichlorobenzidine, 3,3 - 91-94-1Dichlorodiphenyldichloroethane (DDD) 72-54-8Dichlorodiphenyldichloroethene (DDE) 72-55-9Dichlorodiphenyltrichloroethane (DDT) 50-29-3Dichlorophenoxyacetic acid, 2,4 - 94-75-7Diethyl Phthalate 84-66-2Dimethylphenol, 2,4 - 105-67-9Di-n-butyl Phthalate 84-74-2

99-65-0Dinitrobenzene, 1,2 - 528-29-0Dinitrotoluene, 2,4 - 121-14-2Dinitrotoluene, 2,6 - 606-20-2Endrin 72-20-8Ethylene Glycol 107-21-1 Cal/EPA human respiratory system, kidney, developmentFluoranthene 206-44-0Fluorene 86-73-7Heptachlor 76-44-8Heptachlor Epoxide 1024-57-3Hexachloro- 1,3 - Butadiene 87-68-3Hexachlorobenzene 118-74-1Hexachloroethane 67-72-1Indeno(1,2,3-c,d)pyrene 193-39-5 NOAEL tremors Weeks et al. 1979 rat 30


Hexane, n -



A5


C5

Intermediate (15-364 days) and chronic (365 days or greater) inhalation MRLs based on LOAEL of 1,250 ppm.

G5

ATSDR reference for MRL Stewart RD, Hake CL, Wu A, et al. Acetone: Development of a Biological Standard for the Industrial Worker by Breath Analysis. Cincinnati, OH: National Institute for Occupational Safety and Health. NTIS PB82-172917.

K5

10 for use of LOAEL and 10 for human variability

A6


C6

BMCL = 8.2 mg/m3

G6

IRIS Inhalation RfC Principal and Supporting Studies Rothman, N., G.L. Li, M. Dosemeci, W.E. Bechtold, G.E. Marti, Y.Z. Wang, M. Linet, L.Q. Xi, W. Lu, M.T. Smith, N. Titenko-Holland, L.P. Zhang, W. Blot, S.N. Yin, and R.B. Hayes. 1996. Hematotoxicity among Chinese workers heavily exposed to benzene. Am. J. Ind. Med. 29: 236-246. Ward, C.O., R.A. Kuna, N.K. Snyder, R.D. Alsaker, W.B. Coate, and P.H. Craig. 1985. Subchronic inhalation toxicity of benzene in rats and mice. Am. J. Ind. Med. 7: 457-473.

K6

A factor of 3 because the BMC is considered to be an adverse effect level, a factor of 10 was used for intraspecies differences in response (human variability),a UF of 3 for subchronic-to-chronic extrapolation was applied, and finally, a UF of 3 was chosen to account for database deficiencies

A7


C7

BMC: 19.7 mg/ cu. M Assuming 25 C and 760 mmHg, BMC (mg/cu.m) = 17.7 x 76.15/24.45 = 55.1 mg/cu.m. This is an extrarespiratory effect of a gas exposure. The BMC is based on an 8-hour TWA occupational exposure. MVho = 10 cu.m/day, MVh = 20 cu.m/day. BMC(HEC) = 55.1 mg/cu.m x (MVho/MVh x 5 days/7 days = 19.7 mg/cu.m.

G7

IRIS Inhalation RfC Principal Studies Johnson, B.L., J. Boyd, J.R. Burg, S.T. Lee, C. Xintaras and B.E. Albright. 1983. Effects on the peripheral nervous system of workers' exposure to carbon disulfide. Neurotoxicology. 4(1): 53-66. HEAST reference #010975 Johnson BL, J Boyd, JR Burg et al. 1983. Effects On The Peripheral Nervous System Of Workers' Exposure To Carbon Disulfide. Neurotoxicology 4: 53-66. US EPA. 1995. RfD/RfC Work Group.

K7

An uncertainty factor of 3 reflects extrapolation of human data to sensitive humans. A factor of 10 is applied to account for both database deficiencies, including concern for possible developmental effects at low levels, and to extrapolate to a lifetime exposure.

A8


C8

LOAEL: 31 mg/ cu. m

G8

Adams, E.M., H.C. Spencer, V.K. Rowe, D.D. McCollister and D.D. Irish. 1952. Vapor toxicity of carbon tetrachloride determined by experiments on laboratory animals. Arch. Ind. Hyg. Occup. Med. 6: 50-66.

K8

3 for use of LOAEL, 3 for interspecies extrapolation using dosimetric adjustment, 3 for database deficiencies, 10 for subchronic to chronic extrapolation, and 10 to for human variation

A9


A10


C10

NOAEL: 4000 mg/cu.m (1504 ppm) NOAEL(ADJ): 4000 mg/cu.m NOAEL(HEC): 4000 mg/cu.m LOAEL: 13,000 mg/cu.m (4946 ppm) LOAEL(ADJ): 13,000 mg/cu.m LOAEL(HEC): 13,000 mg/cu.m

G10

IRIS Inhalation RfC Principal Study Scortichini, B.H., K.A. Johnson, J.J. Momany-Pfruender, and T.R. Hanley, Jr. 1986. Ethyl chloride: Inhalation teratology study in CF-1 mice. Dow Chemical Co. EPA Document #86-870002248. HEAST reference #010371 Scortichini BH, KA Johnson, JJ Momany-Pfruender et al. 1986. Ethyl Chloride: Inhalation Teratology Study In CF-1 Mice. Dow Chemical Co. EPA 86-870002248. US EPA. 1990. RfD/RfC Work Group.

K10

A factor of 10 is used to account for sensitive populations. An uncertainty factor of 3 (rather than 10) is used for interspecies extrapolation due to dosimetric adjustment of the inhaled concentration. As no multigeneration reproductive study and no definitive developmental toxicity studies were available, a full factor of 10 is proposed for database deficiencies.

A11


C11

Chronic MRL based on LOAEL of 2 ppm. Intermediate MRL based on LOAEL of 14 ppm.

G11

ATSDR Reference Bornski H, Sobolewska A, Strakowski A. 1967. [Toxic damage of the liver by chloroform in chemical industry workers.] Int Arch F Gewerbepathologie u. Gewerbehygiene 24: 127- 134 Phoon WH, Goh KT, Lee LT, et al. 1983. Toxic jaundice from occupational exposure to chloroform. Med J Malaysia 38:31-34.

A12


A13


C13

LOAEL: 482.3 mg/kd/day

G13

HEAST reference #005497 Prendergast JA, RA Jones, LJ Jenkins, And J Seigal. 1967. Effects On Experimental Animals Of Long-Term Inhalation Of Trichloroethylene, Carbon Tetrachloride, 1,1,1-Trichloroethane, Dichlorodifluoromethane, and 1,1-Dichlorothylene. Toxicol Appl Pharmacol 10: 270-289. US EPA. 1987. Health Effects Assessment For Fully Halogenated Methanes. Prepared By The Office Of Health And Environmental Assessment, Environmental And Criteria and Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A14


C14

NOEL: 138 mg/kg/day

G14

HEAST reference #005789 Hoffman HT, H Birnstiel, And P Jobst. 1971. On The Inhalation Toxicity of 1,1- And 1,2-Dichloroethane. Arch Toxikol 27: 248-265. UA EPA. 1984. Health Effects Assessment For 1,1-Dichloroethane. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A15


C15

Chronic inhalation MRL based on NOAEL of Intermediate inhalation MRL based on LOAEL of

G15

ATSDR Reference Cheever KL, Cholakis JM, el-Hawari AM, et al. 1990. Ethylene dichloride: The influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats. Fundam Appl Toxicol 14:243-261. NTP. 1991a. Toxicity studies of 1,2-dichloroethane (ethylene dichloride) (CAS No. 107-06-2) in F344/N rats, Sprague Dawley rats, Osborne-Mendel rats and B6C3F1 mice (drinking water and gavage studies). Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institute of Health, National Toxicology Program. NIH Publication No. 91-3123.

K15

3 for interspecies extrapolation, 10 for human variability, and 3 as a modifying factor for database deficiencies.

A16


C16

BMCL10HEC: 6.9 mg/m3

G16

IRIS Inhalation RfC Principal Study Quast, JF; Mckenna, MJ; Rampy, LW; et al. (1986) Chronic toxicity and oncogenicity study on inhaled vinylidene chloride in rats. Fundam Appl Toxicol 6:105-144.

K16

Individual UFs of 10 each were used for interspecies extrapolation and intraspecies variability because there were no applicable data to justify departure from the default values.

A17


A18


A19


C19

NOAEL: 69.3 mg/cu. m LOAEL: 69.3 mg/cu.m (15 ppm) LOAEL(ADJ): 12.4 mg/cu.m LOAEL(HEC): 1.3 mg/cu.m

G19

IRIS Inhalation RfC Principal Study Nitschke K.D., K.A. Johnson, D.L. Wackerle, J.E. Phillips and D.A. Dittenber. 1988. Propylene dichloride: A 13-week inhalation toxicity study with rats, mice, and rabbits. Dow Chemical Company, Mammalian and Environmental Toxicology Research Laboratory, Midland, MI. OTS Doc. #86-870001397 HEAST reference # 005898 Nitschke KD, KA Johnson, DL Wackerle, JE Phillips, DA Dittenber. 1988. Propylene Dichloride: A 13 Week Inhalation Toxicity Study With Rats, Mice, And Rabbits. Dow Chemical Co. Mammalian And Environmental Toxicological Research Laboratory. Midland, MI. US EPA. 1985. Health And Environmental Effects Profile For Dichloropropanes. Prepared By The Office Of Health And Enviornmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergency Response, Washington, DC. US EPA. 1991. RfD/RfC Work Group.

K19

The uncertainty factor of 300 reflects a factor of 10 to protect sensitive individuals. A factor of 3 is used for extrapolation from a subchronic study, since study of the critical effect shows little progression with exposure time. A factor of 3 is used for the use of a minimal LOAEL due to the minimal nature of the effect. A factor of 3 is used for interspecies extrapolation due to the use of dosimetric adjustments. The factors of 3 represent operational application of a geometric half of the standard factor of 10, rounded to a single significant figure. As a result, multiplication of 3 factors of 3 results in a composite factor of 30.

A20


C20

BMCL10(ADJ)1: 3.7 mg/m3 BMCL10(HEC)2: 0.72 mg/m3 BMC10(ADJ)1: 5.9 mg/m3 BMC10(HEC)2: 1.2 mg/m3 NOAEL: 5 ppm

G20

IRIS Inhalation RfC PRincipal Study Lomax, LG; Stott, WT; Johnson, KA; et al. (1989) The chronic toxicity and oncogenicity of inhaled technical-grade 1,3-dichloropropene in rats and mice. Fundam Appl Toxicol 12:418-431. HEAST reference #010351 Lomax LG, WT Stott, KA Johnson, et al. 1989. The Chronic Toxicity And Oncogenecity Of Inhaled Technical-Grade 1,3-Dichloropropene In Rats And Mice. Fund Appl Toxicol 10: 214. US EPA. 1989. Health And Environmental Effects Document For 1,3-Dichloropropene. Prepared By The Office Of Health And Envrionmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergemcy Response, Washington, DC. US EPA. 1990. RfD/RfC Work Group.

K20

the default uncertainty factor for interspecies extrapolation is 10. Half of that factor, 101/2, or 3, reflects the pharmacokinetic component of interspecies uncertainty and half represents the pharmacodynamic component of interspecies uncertainty.

A21


C21

Chronic inhalation MRL based on NOAEL of 111 ppm.

G21

ATSDR reference for MRL Torkelson R, Leong BKL, Kociba RJ, et al. 1974. 1,4-Dioxane. II. Results of a 2-year Inhalation Study in Rats. Toxicol Appl Pharmacol 30:287-298.

K21

3 for animal to human extrapolation using dosimetric adjustment and 10 to protect sensitive populations.

A22


A23


C23

NOAEL: 434 mg/cu.m (100 ppm) NOAEL(ADJ): 434 mg/cu.m NOAEL(HEC): 434 mg/cu.m LOAEL: 4340 mg/cu.m (1000 ppm) LOAEL(ADJ): 4340 mg/cu.m LOAEL(HEC): 4340 mg/cu.m

G23

IRIS Inhalation RfC Principal Studies Andrew, F.D., R.L. Buschbom, W.C. Cannon, R.A. Miller, L.F. Montgomery, D.W. Phelps, et al. 1981. Teratologic assessment of ethylbenzene and 2- ethoxyethanol. Battelle Pacific Northwest Laboratory, Richland, WA. PB 83- 208074., 108. Hardin, B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles and R.W. Niemeier. 1981. Testing of selected workplace chemicals for teratogenic potential. Scand. J. Work Environ. Health. 7(suppl 4): 66-75.

K23

The uncertainty factor of 300 reflects a factor of 10 to protect unusually sensitive individuals, 3 to adjust for interspecies conversion and 10 to adjust for the absence of multigenerational reproductive and chronic studies.

A24


C24

Chronic inhalation MRL based on LOAEL of 0.24 ppm. Intermediate inhalaton MRL based on NOAEL of 0.98 ppm and LOAEL of 2.95 ppm.

G24

ATSDR reference for MRL Holmstrom M,Wilhelmsson B, Hellquist H, et al. 1989c. Histological changes in the nasal mucosa in persons occupational exposed to formaldehyde alone and in combination with wood dust. Acta Otolaryngol (Stockh) 108:274-283. Rusch GM, Clary JJ, Rinehart WE, et al. 1983. A 26-week inhalation toxicity study with formaldehyde in the monckey, rat, and hamster. Toxicol Appl Pharmacol 68:329-343.

K24

3 for use of a minimal LOAEL and 10 for human variability

L24


A25


A26


C26

BMC: 550 mg/m3 BMCL: 430 mg/m3 BMCLADJ: 215 mg/m3 BMCLHEC: 215 mg/m3

G26

IRIS Inhalation RfC Principal Study Huang, J; Kato, K; Shibata, E; et al. (1989) Effects of chronic n-hexane exposure on nervous system-specific and muscle-specific proteins. Arch Toxicol 63:381-385.

K26

A total uncertainty factor (UF) of 300 was applied to the point of departure of 215 mg/m3: 10 for intraspecies variation (UFH: human variability); 3 for interspecies differences (UFA); 3 to extrapolate to chronic exposure from data in a less-than lifetime study (UFS); and 3 to account for database deficiencies (UFD).

A27


A28


A29


C29

LEC: 5,202 mg/m3 LEC(ADJ): 1,517 mg/m3 LEC(HEC): 1,517 mg/m3

G29

IRIS Inhalation RfC Principal and Supporting Studies Deacon, MM; Pilny, MD; John, J.A; et al. (1981) Embryo- and fetotoxicity of inhaled methyl ethyl ketone in rats. Toxicol Appl Pharmacol 59:620-2. Dow Chemical Corporation. (1979) Teratologic evaluation of inhaled methyl ethyl ketone in rats. OTS Fiche #0205871. Document No. 878211793. Schwetz, BA; Mast, TJ; Weigel, R.J; et al. (1991) Developmental toxicity of inhaled methyl ethyl ketone in mice. Fund Appl Toxicol 16:742-748. Mast, TJ; Dill, JA; Evanoff, JJ; et al. (1989) Inhalation developmental toxicology studies: teratology study of methyl ethyl ketone in mice. Final report. Prepared by Pacific Northwest Laboratory, Battelle Memorial Institute, for the National Toxicology Program, Washington, DC. PNL-6833 UC-408. NTP (National Toxicology Program). (1990) Inhalation developmental toxicology studies: teratology study of methyl ethyl ketone (CAS No. 78-93-3) in mice. NTP study: TER88046. Research Triangle Park, NC. HEAST reference #010845 Schwetz, BA; Mast, TJ; Weigel, R.J; et al. (1991) Developmental toxicity of inhaled methyl ethyl ketone in mice. Fund Appl Toxicol 16:742-748. Mast, TJ; Dill, JA; Evanoff, JJ; et al. (1989) Inhalation developmental toxicology studies: teratology study of methyl ethyl ketone in mice. Final report. Prepared by Pacific Northwest Laboratory, Battelle Memorial Institute, for the National Toxicology Program, Washington, DC. PNL-6833 UC-408. US EPA. 1991. RfD/RfC Work Group.

K29

A 3-fold uncertainty factor was used for interspecies extrapolation. A 10-fold uncertainty factor for intraspecies differences was used to account for potentially susceptible individuals within the human population. A 10-fold uncertainty factor was used to account for database deficiencies.

A30


C30

NOAELHEC = 1026 mg/m3 LOAELHEC = 3073 mg/m3 NOEL: 50 ppm

G30

IRIS Inhalation RfC Principal and Supporting Studies Tyl, R.W., K.A. France, L.C. Fisher, I.M. Pritts, T.R. Tyler, R.D. Phillips, and E.J. Moran. (1987) Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice. Fundam Appl Toxicol 8:310-327. WIL Research Laboratories. (2000) An inhalation two-generation reproductive toxicity study of methyl isobutyl ketone (MIBK) in rats. (Revised audited draft of only the first of 9 volumes). Sponsored by the Chemical Manufacturers Association. Lab Study No. WIL-186007; Sponsor Study No. KET-14.0-MIBK-WIL. HEAST reference #005562 Union Carbide Corp. 1983. Ninety-Day Inhalation Study In Rats And Mice Sponsored By CMA. US EPA/OTS Public Files 0750507469. US EPA. 1987. Health Effects Assessment For Methyl Ethyl Ketone. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

K30

An uncertainty factor of 3 was used for interspecies extrapolation. A factor of 10 was not used because EPA guidance (U.S. EPA, 1994) was followed for animal-to-human dosimetric adjustment of exposure levels. A factor of 10 was used for intraspecies variability. An additional uncertainty factor of 10 for database deficiency was also applied, based on the lack of developmental neurotoxicity data and definitive neurotoxicity data in general, and based on the lack of any chronic toxicity data.

A31


C31


G31

IRIS Inhalation RfC Principal Study Chun, J.S., H.D. Burleigh-Flayer, and W.J. Kintigh. 1992. Methyl tertiary butyl ether: vapor inhalation oncogenicity study in Fischer 344 rats (unpublished material). Prepared for the MTBE Committee by Bushy Run Research Center, Union Carbide Chemicals and Plastics Company Inc. Docket No. OPTS- 42098.

K31

An uncertainty factor of 10 is applied to account for extrapolation to sensitive human subpopulations. An additional factor of 3 is used to account for interspecies extrapolation. A full 10-fold adjustment for interspecies extrapolation is not deemed necessary due to the use of dosimetric adjustments. An uncertainty factor of 3 is applied for database deficiencies because of the lack of certain information from the chronic exposure bioassay (e.g., urinalysis results, serum chemistry, and limited reporting of motor activity/clinical signs during exposure).

A32


C32

NOAEL: 50 ppm LOAEL: 25 ppm

G32

ATSDR Reference Nitschke KD, Burek JD, Bell TJ, et al. 1988a. Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:48-59. Haun CC, Vernot EH, Darmer KI, et al. 1972. Continuous animal exposure to low levels of dichloromethane. In: Proceedings of the 3rd annual conference on environmental toxicology. Wright Patterson Air Force Base, OH: Aerospace Medical Research Laboratory, 199-208. AMRL-TR-72-130. AD 773766.

K32

3 for extrapolation fron animals to humans and 10 for human variability

L32

3 for use of minimal LOAEL, 3 for extrapolation from animals to humans, and 10 for human variability

A33


C33

NOAEL: 94 mg/cu.m (25 ppm = 150 mmole urinary styrene metabolites/mole creatinine adjusted to lower 95% confidence limit = 22 ppm) NOAEL(HEC): 34 mg/cu.m LOAEL: >94 mg/cu.m (>22 ppm derived as in NOAEL listing)

G33

IRIS Inhalation RfC Principal Study Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini. 1984. Exposure-effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am. J. Ind. Med. 5: 275-286.

K33

A partial UF of 3 was used for database inadequacy, including the lack of concentration-response information on respiratory tract effects. A partial UF of 3 instead of 10 was used for intraspecies variability since the lower 95% confidence limit of the exposure extrapolation was used and because Perbellini et al. (1988) demonstrated that this biological exposure index (i.e., urinary metabolites) accounts for differences in pharmacokinetic/ physiologic parameters such as alveolar ventilation rate. A partial UF of 3 instead of 10 was also evoked for lack of information on chronic studies as the average exposure duration of the principal study of Mutti et al. (1984) was not long enough (8.6 years) to be considered chronic. The total uncertainty is therefore 30 (three times the one-half logarithm of 10).

A34


A35


A36


C36

Chronic Inahalation MRL based on LOAEL of 15 ppm.

G36

ATSDR reference for MRL Ferroni C, Selis L, Mutti A, et al. 1992. Neurobehavioral and neuroendocrine effects of occupational exposure to perchloroethylene. NeuroToxicology 13: 243-247.

K36

10 for use of LOAEL and 10 for human variability

A37


A38


A39


A40


C40

LOAEL: 32 ppm

G40

Cal/EPA. 2003. Table of All Chronic Reference Exposure Levels Adopted by OEHH as of August 2003. http://oehha.ca.gov/air/chronic_rels/pdf/79016.pdf Vandervort R, and Polnkoff P. 1973. NIOSH: Health hazard evaluation/toxicity determination. Dunham-Bush, Inc. Report 72-34.

K40

10 for use of LOAEL and 10 for Intraspecies variability

A41


C41

LOAEL: 1940 mg/kg/day

G41

HEAST reference #005501 Jenkins, LJ, RA Jones, RA Coon, And J Siegal. 1970. Repeated And Continuous Exposures Of Laboratory Animals To Trichlorofluoromethane. Toxicol Appl Pharmacol. 16: 133-142. US EPA. 1987. Health Effects Assessment For Fully Halogenated Methanes. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A42


A43


C43

NOAEL: 0.13 mg/kg-day NOAEL(HEC): 2.5 mg/m3 LOAEL: 1.3 mg/kg-day LOAEL(HEC): 25.3 mg/m3

G43

IRIS Inhalation RfC Principal Studies Til, HP; Feron, VJ; Immel, HR. (1991) Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem Toxicol 29:713-718. Til, HP; Immel, HR; Feron, VJ. (1983) Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. Civo Institutes. TNO Report No. V 83.285/291099, TSCATS Document FYI-AX-0184-0353, Fiche No. 0353.

K43

An uncertainty factor of 10 was used for protection of sensitive human subpopulations and 3 for animal-to-human extrapolation.

A44


C44

NOAEL: 50 ppm NOAEL(HEC): 39 mg/m3 LOAEL: 100 ppm LOAEL(HEC): 78 mg/m3

G44

IRIS Inhalation RfC Principal Study Korsak, Z; Wisniewska-Knypl, J; Swiercz, R. (1994) Toxic effects of subchronic combined exposure to n-butyl alcohol and m-xylene in rats. Int J Occup Med Environ Health 7:155-166.

K44

A UF of 3 was applied to account for laboratory animal-to-human interspecies differences. A uncertainty factor of 10 was applied for intraspecies uncertainty to account for human variability and sensitive populations. A UF of 3 was applied for extrapolation from subchronic to chronic duration. A UF of 3 was applied for uncertainties in the database.

A46


A47


A48


C48

LOAEL: 43 mg/cu.m (20 ppm) LOAEL (ADJ): 7.7 mg/cu.m LOAEL (HEC): 1.9 mg/cu.m

G48

IRIS Inhalation RfC Principal Study Quast J.F., D.J. Schwetz, M.F. Balmer, T.S. Gushow, C.N. Park and M.J. McKenna. 1980. A two-year toxicity and oncogenicity study with acrylonitrile following inhalation exposure of rats. Dow Chemical Co., Toxicology Research Laboratory, Midland, MI.

K48

The uncertainty factor of 1000 reflects a factor of 10 to protect unusually sensitive individuals and 3 to adjust from a minimally adverse LOAEL to a NOAEL. An uncertainty factor of 3 for interspecies variability is used because the use of the dosimetric adjustments account for part of this area of uncertainty. An additional factor of 10 is applied due to an incomplete database, or more specifically, the lack of an inhalation bioassay in a second species, and the lack of reproductive data by the inhalation route with the existence of an oral study showing reproductive effects.

A49


C49

NOAEL: 19 mg/cu.m (5 ppm) NOAEL(ADJ): 3.4 mg/cu.m NOAEL(HEC): 3.4 mg/cu.m LOAEL: None NOAEL: None LOAEL: 64.7 mg/cu.m (17 ppm) LOAEL(ADJ): 11.6 mg/cu.m LOAEL(HEC): 11.6 mg/cu.m

G49

IRIS Inhalation RfC Principal Studies Oberst F.W., E. Hackley, C. Comstock. 1956. Chronic toxicity of aniline vapor (5 ppm) by inhalation. Arch. Ind. Health. 13: 379-384. duPont deNemours and Company, Inc. 1982. Subacute inhalation toxicity study of aniline in rats. OTS No. 878220240. Fiche No. 0215025. Available from EPA. Write to FOI, EPA, Washington, DC 20460. Co-principal studies are chosen to delineate effect levels. The study of Oberst et al. (1956), which demonstrated a NOAEL, was complemented by the duPont deNemours (1982) study which provided a LOAEL.

K49

Uncertainty factors of 10 are used for the protection of sensitive human subpopulations, 10 to allow for animal to human variability, 10 for use of a subchronic study, and 3 for lack of appropriate reproductive studies.

A50


A51


A52


A53


A54


A55


A56


A57


A59


C59

NOAEL 1.0 mg/cu m NOAEL (ADJ) 0.24 mg./cu m NOAEL (HEC) 0.65 mg/cu m

G59

IRIS Inhalation RfC Principal Study Khasawinah, A., C. Hardy, and G. Clark. 1989a. Comparative inhalation toxicity of technical chlordane in rats and monkeys. J. Toxicol. Environ. Health 28(3): 327-347. (The 90-day rat study.)

K59

The following uncertainty factors are applied to the NOAEL(ADJ): 10 for subchronic to chronic extrapolation; 10 for consideration of intraspecies variation. Partial uncertainty factors are used for interspecies extrapolation (which already has been addressed partially by calculation of an HEC) and for database deficiencies (lack of any reproductive studies).

A60


A61


A62


C62

NOEL: 49 ppm

G62

HEAST reference #005412 Hollingsworth RL, VK Rowe, F Oyen, TR Torkelson, And EM Adams. 1958. Toxicity Of O-Dichlorobenzene. Am Med Assoc Arch Ind Health 17(1): 180-187. US EPA. 1987. Health Effects Assessment For Dichlorobenzenes. Prepared By The Office Of Health And Environmental Assessment, Environmental Cirteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A63


C63


G63

IRIS Inhalation RfC Principal Study Chlorobenzene Producers Association. 1986. Parachlorobenzene: Two-generation Reproduction Study in Sprague-Dawley Rats. Study 86-81-90605. MRID No. 411088-1. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

K63

An uncertainty factor of 10 was used to account for sensitive subpopulations among humans. An uncertainty factor of 3 rather than 10 was used to account for interspecies differences since dosimetry adjustments were applied. An additional factor of 3 was used since the NOAEL was based on a subchronic rather than chronic study. A full factor of 10 was not used because the LOAEL estimated by a route-to-route extrapolation from the chronic NTP (1987) oral study suggested limited progression of the hepatic lesions when terminal results were compared with interim kills. In addition, comparison of histopathologic results from the interim and final kills of the Riley et al. (1980) study also indicated that there was no progression in severity of liver lesions.

A64


A65


A66


A67


A68


A69


A70


A71


A72


A73


A74


A75


A76


A77


A78


A79


A80


A81


A82


A83


A84


A85


C85

Intermediate inhalation MRL based on NOAEL of 48 ppm.

G85

ATSDR MRL reference Weeks MH, Angerhofer RA, Bishop R, et al. 1979. The toxicity of hexachloroethane in laboratory animals. Am Ind Hyg Assoc 40: 187-199.

K85

3 to extapolate from animals to humans and 10 for human variability

Isophorone 78-59-1 Cal/EPA development, liverIsopropylbenzene (Cumene) 98-82-8 NOAEL/LOAEL medium increased kidney weights in females and adrenal weight increase 1 Cushman et al. 1995 rat kidney 1000Lindane 58-89-9m-cresol 108-39-4Methoxychlor 72-43-5Methylnaphthalene, 1 - 90-12-0Naphthalene 91-20-3 LOAEL low/medium hyperplasia and metaplasia in respiratory & olfactory epithelium 1 NTP 1992 mouse nasal 3000Nitrobenzene 98-95-3 LOAEL hematological effects, adrenal lesions, kidney lesions, and liver lesions 1 U.S. EPA 1987 mouse blood, kidney, liver 10000 1000

86-30-6o-cresol 95-48-7

117-84-0p-cresol 106-44-5Pentachlorophenol 87-86-5Phenol 108-95-2 Cal/EPA alimentary system, cardiovascular system, kidney, nervous system

Polychlorinated Biphenyls 1336-36-3Pyrene 129-00-0Pyridine 110-86-1Silvex 93-72-1Toxaphene 8001-35-2Trichlorophenol, 2,4,5 - 95-95-4Trichlorophenol, 2,4,6 - 88-06-2Trimethylbenzene, 1,2,4 - 95-63-6 LOAEL low CNS effects, asthma-like bronchitis, anemia, blood clot effects 1 Battig et al. 1958 human 3000Trimethylbenzene, 1,3,5 108-67-8 LOAEL-HEC low CNS effects, asthma-like bronchitis, anemia, blood clot effects 1 Battig et al. 1958 human 3000Trinitrobenzene, 1,3,5 - (s) 99-35-4Vinyl Acetate 108-05-4 NOAEL/LOAEL high epithelial lesions; inflamation of turbinate epithelium, mild multifocal bronchitis 1 Owen; Hazelton 1988; 1980 rat, mouse nasal 30 100

Inorganic AnalytesAntimony 7440-36-0Arsenic, Inorganic 7440-38-2Barium and Compounds 7440-39-3 NOEL fetotoxicity 1 U.S. EPA 1984 rat fetus 1000 100Beryllium and Compounds 7440-41-7 LOAEL medium sensitization and progression to Chronic Beryllium Disease (CBD) 1 Kreiss et al. 1996 human 10 10Cadmium 7440-43-9Chromium (III) (Insoluble Salts) 16065-83-1Chromium (VI) (chromic acid mists) 18540-29-9 LOAEL low septum atrophy 1 Lindberg and Hedenstierna 1983 human nasal 90Chromium (VI) (particulates) 18540-29-9 BMD medium Lactate dehydrogenase in bronchioalveolar lavage fluid 1 Malsch et al. 1994 rat respiratory system 300Cobalt and Compounds 7440-48-4 NOAEL medium-to-low lung function 1 Nemery 1992 human lung 100Cyanide, Free 57-12-5Fluorine (soluble fluoride) 7782-41-4Mercury (elemental) 7439-97-6 LOAEL medium hand tremor, increse in memory disturbance, slight (sunjective and objective) autonomic dysfunction 1 Liang et al. 1993 human 30Methyl Mercury 22967-92-6Nickel (Soluble Salts) 7440-02-0Selenium and Compounds 7782-49-2Silver 7440-22-4Thallium (I) Nitrate 10102-45-1Thallium Acetate 563-68-8Thallium Carbonate 6533-73-9Thallium Chloride 7791-12-0Thallium Sulfate 7446-18-6Vanadium Pentoxide 1314-62-1Vanadium, Metallic 7440-62-2Zinc and Compounds 7440-66-6

Supplemental Criteria2-methylnaphthalene 91-57-6 NOAEL high neurological effects 1 Foo et al. (multiple studies) '1990 (multiple studies)' human 104-chlorotoluene 106-43-4Acenaphthylene 208-96-8Benzo(g,h,i)perylene 191-24-2Copper 7440-50-8Dimethyl phthalate 131-11-3Methyl butyl ketone 591-78-6 NOEL-HEC low/medium reduced fetal body weight, skeletal variations, increased fetal death; increased liver weight & kidney effects 1 Tyl et al. 1987 rat and mouse fetus; liver, kidney 300 100n-butyl benzene 104-51-8 NOAEL high neurological effects 1 Foo et al. (multiple studies) '1990 (multiple studies)' human 10n-propyl benzene 103-65-1 NOAEL/LOAEL medium increased kidney weights in females and adrenal weight increase; nervous system involvement, nose irritation 1 Cushman et al. 1995 rat kidney; central nervous system, nose 1000 1000Phenanthrene 85-01-8p-isopropyltoluene (Cymene) 99-87-6Sec-butyl benzene 135-98-8 NOAEL high neurological effects 1 Foo et al. (multiple studies) '1990 (multiple studies)' human 10Tert-butyl benzene 98-06-6 NOAEL high neurological effects 1 Foo et al. (multiple studies) '1990 (multiple studies)' human 10



A86


A87


C87

NOAEL: 2438 mg/cu.m (496 ppm) NOAEL(ADJ): 435 mg/cu.m NOAEL(HEC): 435 mg/cu.m LOAEL: 5909 mg/cu.m (1202 ppm) LOAEL(ADJ): 1055 mg/cu.m LOAEL(HEC): 1055 mg/cu.m HEAST NOAEL: 105.1 ppm

G87

IRIS Inhalation RfC Principal Study Cushman, J.R., J.C. Norris, D.E. Dodd, K.I. Darmer, and C.R. Morris. 1995. Subchronic inhalation toxicity assessment of cumene in Fischer 344 rats. J. Am. Coll. Toxicol. 14(2): 129-147.

K87

The following full uncertainty factors are applied to the NOAEL: 10 for subchronic-to-chronic extrapolation and 10 for consideration of intraspecies variation. Partial uncertainty factors also are applied to this effect level for consideration of interspecies extrapolation (which already has been addressed partially through the calculation of an HEC) and for database deficiencies (lack of reproductive studies). The total UF = 10 x 10 x 3 x 3, which is rounded to 1000.

A88


A89


A90


A92


C92

LOAEL(HEC): 9.3 mg/m3

G92

IRIS Inhalation RfC Principal Study National Toxicology Program (NTP). (1992a) Toxicology and carcinogenesis studies of naphthalene in B6C3F1 mice (inhalation studies). Technical Report Series No. 410. NIH Publication No. 92-3141.

K92

The adjusted LOAEL(HEC) of 9.3 mg/m3 for nasal effects (hyperplasia in respiratory epithelium and metaplasia in olfactory epithelium) was divided by an uncertainty factor of 3000 (10 to extrapolate from mice to humans, 10 to protect sensitive humans, 10 to extrapolate from a LOAEL to a NOAEL, and 3 for database deficiencies including the lack of a 2-generation reproductive toxicity study and chronic inhalation data for other animal species) to arrive at a chronic RfC for naphthalene of 3E-3 mg/m3.

A93


C93

LOAEL: 25 mg/ cu. m

G93

HEAST reference #010518 CIIT (Chemical Industry Instatute Of Toxicology). 1984. Ninety-Day Inhalation Study Of Nitrobenzene In F-344 Rats, CD Rats, And B6C3F1 Mice With Cover Letter Dated 6/24/84 And EPA Response Dated 8/6/84. Unpublished Study. FYI-OTS-0784-0333 And Computer Print-Out Of Pathology Finding. US EPA. 1987. Health Effects Assessment For Nitrobenzene. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A94


G94

HEAST reference #010518 CIIT (Chemical Industry Instatute Of Toxicology). 1984. Ninety-Day Inhalation Study Of Nitrobenzene In F-344 Rats, CD Rats, And B6C3F1 Mice With Cover Letter Dated 6/24/84 And EPA Response Dated 8/6/84. Unpublished Study. FYI-OTS-0784-0333 And Computer Print-Out Of Pathology Finding. US EPA. 1987. Health Effects Assessment For Nitrobenzene. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A95


A97


A98


A99


A100


A101


A102


A103


A104


A105


A106


A107


A108


A109


A110


C110

NOAEL: 176 mg/cu.m (50 ppm) NOAEL(ADJ): 31 mg/cu.m NOAEL(HEC): 5 mg/cu.m LOAEL: 704 mg/cu.m (200 ppm) LOAEL(ADJ): 126 mg/cu.m LOAEL(HEC): 19 mg/cu.m NOAEL: 50 ppm (ATSDR) LOAEL: 200 ppm (ATSDR)

G110

IRIS Inhalation RfC Principal And Supporting Studies The principal study of Owen (1988) comprises the pathology reports on Owen's animals done by Beems (1988) and Dreef-van der Meulen (1988). Owen, P.E. 1988. Vinyl acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazleton Laboratories Europe Ltd., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No.: 5547-51/15. November 1988. Dreef-van der Meulen, H.C. 1988. Report No. V 88.033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with vinyl acetate: Revised version. (TNO-CIVO Institutes, October 1988). Beems, R.B. 1988. Report No. V 88.133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with vinyl acetate. (TNO-CIVO Institutes, April 1988). ATSDR Reference Hazleton. 1980b. Vinyl acetate: 3 month inhalation toxicity study in the mouse. U.S. EPA/OTS public files. Hazleton Labs Europe Ltd. Document no. FYI-OTS-0184-0278.

K110

An uncertainty factor of 10 is used for protection of sensitive human subpopulations. An uncertainty factor of 3 for interspecies variability is used because the use of the dosimetric adjustments account for part of this area of uncertainty.

L110


A112


A113


A114


C114

NOEL: 0.8 mg/ cu. m

G114

HEAST reference #005249 Tarasenko M, O Promin, And A Silayev. 1977. Barium Compounds As Industrial Poisons (An Experimental Study). J Hyg Epidem Microbiol Immonnol. 21: 361. US EPA. 1984. Health Effects Assessment For Barium. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

A115


C115

LOAEL(HEC): 0.55 µg/m3 LOAEL(HEC): 0.20 µg/m3 NOAEL: 0.01-0.1 µg/m3 NOAEL(HEC): 0.01-0.1 µg/m3

G115

IRIS Inhalation RfC Principal And Supporting Studies Kreiss, K; Mroz, MM; Newman, LS; et al. (1996) Machining risk of beryllium disease and sensitization with median exposures below 2 MU-G/M(3). Am J Ind Med 30(1):16-25. Eisenbud, M; Wanta, RC; Dustan, C; et al. (1949) Non-occupational berylliosis. J Ind Hyg Toxicol 31:282-294.

K115

The available data suggest that only a small percentage of the population (1% to 5%) appears to be susceptible to CBD (Kreiss et al., 1994). Because individuals developing beryllium sensitization and CBD are the most sensitive subpopulation, an uncertainty factor of 1 was used to account for human variability. An uncertainty factor of 1 was also used to adjust for the less-than-chronic exposure duration of the Kreiss et al. (1996) study; use of this uncertainty factor is supported by the evidence that the occurrence of CBD does not appear to be related to exposure duration. Because the screening method used in the Kreiss et al. (1996) study was more sensitive than the methods used in the Eisenbud et al. (1949) study, the RfC was derived from the LOAEL (Kreiss et al., 1996) with an uncertainty factor of 3 to account for the sensitive nature of the subclinical endpoint (beryllium sensitization). A database uncertainty factor of 3 was used to account for the poor quality of exposure monitoring in the co-principal studies and other epidemiology studies that assessed the incidence of beryllium sensitization and CBD among exposed workers and community residents. Although there are no developmental studies or 2-generation reproduction studies, a limited continuous breeding study found that beryllium does not cause reproductive or developmental effects following intratracheal administration (Clary et al., 1975). In addition, systemic distribution of beryllium is less than 1% (U.S. EPA, 1987), and any systemic effects would be expected to occur at exposure levels much above the very low levels at which CBD is observed.

A116


A117


A118


C118

LOAEL: 2E-3 mg/m3 7.14 E-4 mg/m3 (adj.)

G118

IRIS Inhalation RfC Principal Study Lindberg, E; Hedensteirna, G. (1983) Chrome plating: Symptoms, finding in the upper airways and effects on lung function. Arch Environ Health 38:367-374.

A119


C119

BMD: 0.016 mg/m3 0.034 mg/m3 (adj.)

G119

IRIS Inhalation RfC Principal And Supporting Studies Glaser, U; Hochrainer, D; Steinhoff, D. (1990) Investigation of irritating properties of inhaled Cr(VI) with possible influence on its carcinogenic action. In: Environmental Hygiene II. Seemayer, NO; Hadnagy, W, eds. Berlin/New York: Springer-Verlag. Malsch, PA; Proctor, DM; Finley, BL. (1994) Estimation of a chromium inhalation reference concentration using the benchmark dose method: a case study. Regul Toxicol Pharmacol 20:58-82.

A121


A122


A123


C123

LOAEL: 0.025 mg/cu.m (converted to LOAEL [ADJ] of 0.009 mg/cu.m)

G123

IRIS Inhalation RfC Principal And Supporting Studies Fawer, R.F., U. DeRibaupierre, M.P. Guillemin, M. Berode and M. Lobe. 1983.Measurement of hand tremor induced by industrial exposure to metallic mercury. J. Ind. Med. 40: 204-208. Piikivi, L. and U. Tolonen. 1989. EEG findings in chlor-alkali workers subjected to low long term exposure to mercury vapor. Br. J. Ind. Med. 46: 370-375. Piikivi, L. and H. Hanninen. 1989. Subjective symptoms and psychological performance of chlorine-alkali workers. Scand. J. Work Environ. Health. 15: 69-74. Piikivi, L. 1989. Cardiovascular reflexes and low long-term exposure to mercury vapor. Int. Arch. Occup. Environ. Health. 61: 391-395. Ngim, C.H., S.C. Foo, K.W. Boey and J. Jeyaratnam. 1992. Chronic neurobehavioral effects of elemental mercury in dentists. Br. J. Ind. Med. 49: 782-790. Liang, Y-X., R-K. Sun, Y. Sun, Z-Q. Chen and L-H. Li. 1993. Psychological effects of low exposure to mercury vapor: Application of a computer-administered neurobehavioral evaluation system. Environ. Res. 60: 320-327.

K123

An uncertainty factor of 10 was used for the protection of sensitive human subpopulations together with the use of a LOAEL. An uncertainty factor of 3 was used for lack of database, particularly developmental and reproductive studies.

A125


A126


A127


A135


A139


A140


A142


C143

NOAELHEC = 1026 mg/m3 LOAELHEC = 3073 mg/m3 NOEL: 50 ppm

G143

IRIS Inhalation RfC Principal and Supporting Studies Tyl, R.W., K.A. France, L.C. Fisher, I.M. Pritts, T.R. Tyler, R.D. Phillips, and E.J. Moran. (1987) Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fischer 344 rats and CD-1 mice. Fundam Appl Toxicol 8:310-327. WIL Research Laboratories. (2000) An inhalation two-generation reproductive toxicity study of methyl isobutyl ketone (MIBK) in rats. (Revised audited draft of only the first of 9 volumes). Sponsored by the Chemical Manufacturers Association. Lab Study No. WIL-186007; Sponsor Study No. KET-14.0-MIBK-WIL. HEAST reference #005562 Union Carbide Corp. 1983. Ninety-Day Inhalation Study In Rats And Mice Sponsored By CMA. US EPA/OTS Public Files 0750507469. US EPA. 1987. Health Effects Assessment For Methyl Ethyl Ketone. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Emergency And Remedial Response, Washington, DC.

K143

An uncertainty factor of 3 was used for interspecies extrapolation. A factor of 10 was not used because EPA guidance (U.S. EPA, 1994) was followed for animal-to-human dosimetric adjustment of exposure levels. A factor of 10 was used for intraspecies variability. An additional uncertainty factor of 10 for database deficiency was also applied, based on the lack of developmental neurotoxicity data and definitive neurotoxicity data in general, and based on the lack of any chronic toxicity data.

C145

NOAEL: 2438 mg/cu.m (496 ppm) NOAEL(ADJ): 435 mg/cu.m NOAEL(HEC): 435 mg/cu.m LOAEL: 5909 mg/cu.m (1202 ppm) LOAEL(ADJ): 1055 mg/cu.m LOAEL(HEC): 1055 mg/cu.m HEAST NOAEL: 105.1 ppm

G145

IRIS Inhalation RfC Principal Study Cushman, J.R., J.C. Norris, D.E. Dodd, K.I. Darmer, and C.R. Morris. 1995. Subchronic inhalation toxicity assessment of cumene in Fischer 344 rats. J. Am. Coll. Toxicol. 14(2): 129-147. HEAST reference #005908 Monsanto Company. 1986. One Month Study Of Cumene Vapor Administered To Male And Female Sprague-Dawley Rats By Inhalation. US EPA/OTS Public Files. 8d Submission. Microfiche# OTS 0513229. US EPA. 1987. Health And Environmental Effects Document For Cumene. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessmnet Office, Cincinnati, OH For The Office Of Solid Waste And Emergency Response, Washington, DC.

K145

The following full uncertainty factors are applied to the NOAEL: 10 for subchronic-to-chronic extrapolation and 10 for consideration of intraspecies variation. Partial uncertainty factors also are applied to this effect level for consideration of interspecies extrapolation (which already has been addressed partially through the calculation of an HEC) and for database deficiencies (lack of reproductive studies). The total UF = 10 x 10 x 3 x 3, which is rounded to 1000.

A146


OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)ORAL SLOPE FACTOR TOXICITY METADATA FOR CHEMICALS OF CONCERN

Chemical CAS # EPA Cancer Class Study Reference Study Reference Date Study Species Study Route Extrapolation Method Target Organ Tumor Type

Volatile Organic Compounds EPA Cancer ClassificationsAcetone 67-64-1 D A = Human CarcinogenBenzene 71-43-2 A U.S. EPA 1999 human inhalation, occupational exposure Linear extrapolation of human occupational data blood leukemia B1 = Probable Human Carcinogen, limited evidence from Carbon Disulfide 75-15-0 NA epidemiologic studiesCarbon Tetrachloride 56-23-5 B2 NCI 1977 hamster/mouse/rat gavage linearized multistage procedure, extra risk liver heptocellular carcinomas/hepatomas B2 = Probable Human Carcinogen, "sufficient: evidenceChlorobenzene 108-90-7 D from animal studies and for which there is inadequateChloroethane 75-00-3 NA evidence or "no data" from epidemiologic studiesChloroform 67-66-3 B2 Cal/EPA C = Possible Human CarcinogenDibromochloromethane 124-48-1 C NTP 1985 mouse gavage linearized multistage procedure, extra risk liver heptocellular adenoma, carcinoma D = Not Classifiable as to Human Carcinogenicity.Dichlorodifluoromethane 75-71-8 NA E = Evidence of Non-Carcinogenicity for HumansDichloroethane, 1,1 - 75-34-3 C Cal/EPA NA = No Data or Not classifiedDichloroethane, 1,2 - 107-06-2 B2 NCI 1978 rat gavage linearized multistage procedure with time-to-death analysis hemangiosarcomasDichloroethene, 1,1 - 75-35-4 C

156-59-2 D 156-60-5 D

Dichloropropane, 1,2 - 78-87-5 B2 Cal/EPADichloropropene, 1,3 - 542-75-6 B2 NTP 1985 mouse oral, gavage linearized multistage model, extra risk bladder carcinomaDioxane, 1,4 - 123-91-1 B2 NCI 1978 rat drinking water linearized multistage procedure, extra risk nasal turbinates squamous cell carcinomaEthyl Ether 60-29-7 NAEthylbenzene 100-41-4 D Formaldehyde 50-00-0 B1 Formic acid 64-18-6 D

110-54-3 NAIsobutyl Alcohol 78-83-1 NAMethanol 67-56-1 NAMethyl Ethyl Ketone (MEK) 78-93-3 NAMethyl Isobutyl Ketone (MIBK) 108-10-1 NA

1634-04-4 NAMethylene Chloride 75-09-2 B2 NTP; NCA 1986; 1983 mouse inhalation; drinking water linearized multistage procedure, extra risk liver heptacellular adenomas, carcinomas, neoplastic nodulesStyrene 100-42-5 NATetrachloroethane , 1,1,1,2 - 630-20-6 C NTP 1983 mouse gavage linearized multistage procedure, extra risk liver adenoma, carcinomaTetrachloroethane, 1,1,2,2 - 79-34-5 C NCI 1978 mouse gavage linearized multistage procedure, extra risk liver carcinomaTetrachloroethene 127-18-4 NA NCI 1977 mouse gavage time-dependent methodology, metabolized dose metric liver carcinomaToluene 108-88-3 NATrichloroethane, 1,1,1 - 71-55-6 D Trichloroethane, 1,1,2 - 79-00-5 C NCI 1978 mouse gavage linearized multistage procedure, extra risk liver carcinomaTrichloroethene 79-01-6 NA NCI; Maltoni et al. 1976; 1986 mouse gavage; inhalation AMET dose metric, non-linear liver tumorsTrichlorofluoromethane 75-69-4 NATrichloropropane, 1,2,3 - 96-18-4 B2 U.S. EPA 1993 rat gavage multiple sites Tumors, benign/malignant, combinedVinyl Chloride 75-01-4 A Feron et al. 1981 rat oral, diet linearized multistage, LED 10/linear method liver heptacellular angiosarcoma, carinoma, and neoplastic nodulesXylenes, Total 1330-20-7 NA

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9 NAAcetophenone 98-86-2 D Acrylonitrile 107-13-1 B1 Biodynamics 1980 rat drinking water linearized multistage procedure, extra risk brain, spinal cord, stomach astrocytomas, carcinomas, papillomasAniline 62-53-3 B2 CIIT 1982 rat diet linearized multistage procedure, extra risk spleen fibrosarcoma, sarcoma, and hemangiosarcomaAnthracene 120-12-7 D Benzidine 92-87-5 A Zavon 1973 human inhalation one-hit with time factor, extra risk bladder tumorsBenzo(a)anthracene 56-55-3 B2 Benzo(a)pyrene 50-32-8 B2 Neal and Rigdon 1967 mouse oral, diet geometric mean of 4 slope factors using differing models forestomach squamous cell papillomas and carcinomasBenzo(b)fluoranthene 205-99-2 B2 Benzo(k)fluoranthene 207-08-9 B2 Bis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 B2 NTP 1982 mouse diet linearized multistage procedure, extra risk liver carcinoma and adenomaButyl Benzyl Phthalate 85-68-7 C NTP 1997 rat pancreas adenoma, carcinomaCarbazole 86-74-8 B2 U.S. EPA 1986 mouse diet liver TumorsChlordane 57-74-9 B2 Khasawinah and Grutsch 1989 mouse diet linearized multistage procedure, extra risk liver carcinomaChrysene 218-01-9 B2 Dibenz(a,h)anthracene 53-70-3 C Dichlorobenzene, 1,2 - (o) 95-50-1 D Dichlorobenzene, 1,4 - (p) 106-46-7 C Cal/EPADichlorobenzidine, 3,3 - 91-94-1 B2Dichlorodiphenyldichloroethane (DDD) 72-54-8 B2 U.S. EPA 1997 mouse gavage liver TumorsDichlorodiphenyldichloroethene (DDE) 72-55-9 B2 Stula et al. 1975 rat diet linearized multistage procedure, extra risk mammary adenocarcinomaDichlorodiphenyltrichloroethane (DDT) 50-29-3 B2 Tomatis et al. 1974 mouse diet linearized multistage procedure, extra risk liver tumorsDichlorophenoxyacetic acid, 2,4 - 94-75-7 NA Rossi et al. 1983 mouse diet linearized multistage procedure, extra risk liver carcinomas, hepatomasDiethyl Phthalate 84-66-2 D Cabral et al. 1982 mouse/rat diet linearized multistage procedure, extra risk liver tumors (benign and malignant)Dimethylphenol, 2,4 - 105-67-9 NADi-n-butyl Phthalate 84-74-2 D

99-65-0 D Dinitrobenzene, 1,2 - 528-29-0 D Dinitrotoluene Mixture, 2,4/2,6- B2 Ellis et al. 1979 rat diet linearized multistage procedure liver, mammary carcinomas, neoplastic nodules, adenomas, fibroadenomas, fribromasDinitrotoluene, 2,4 - 121-14-2 NADinitrotoluene, 2,6 - 606-20-2 B2 Endrin 72-20-8 D Ethylene Glycol 107-21-1 NAFluoranthene 206-44-0 D Fluorene 86-73-7 D Heptachlor 76-44-8 B2 NCI 1977 mouse diet linearized multistage procedure, extra risk liver carcinomasHeptachlor Epoxide 1024-57-3 B2 Velsicol 1973 mouse diet linearized multistage procedure, extra risk liver carcinomaHexachloro- 1,3 - Butadiene 87-68-3 C Erturk et al. 1986 rat diet linearized multistage procedure, extra risk liver carcinomaHexachlorobenzene 118-74-1 B2 Kociba et al. 1977 rat diet linearized multistage procedure, extra risk kidney adenomas, adenocarcinomasHexachloroethane 67-72-1 C NCI 1978 mouse gavage linearized multistage procedure, extra risk liver carcinoma


Hexane, n -



A5


A6


D6

IRIS Slope Factor references Rinsky, RA; Young, RJ; Smith, AB. (1981) Leukemia in benzene workers. Am J Ind Med 2:217-245. Paustenbach, D; Bass, R; Price, P. (1993) Benzene toxicity and risk assessment, 1972-1992: implications for future regulation. Environ Health Perspect 101 (Suppl 6):177-200. Crump, KS. (1994) Risk of benzene-induced leukemia: a sensitivity analysis of the Pliofilm cohort with additional follow-up and new exposure estimates. J Toxicol Environ Health 42:219-242. U.S. EPA. (1998, April 10) Carcinogenic effects of benzene: an update. Prepared by the National Center for Environmental Health, Office of Research and Development. Washington, DC. EPA/600/P-97/001F. U.S. EPA. (1999) Extrapolation of the benzene inhalation unit risk estimate to the oral route of exposure. National Center for Environmental Health, Office of Research and Development. Washington, DC. NCEA-W-0517.

A7


A8


D8

IRIS Slope Factor refeerences Della Porta, G., B. Terracini and P. Shubik. 1961. Induction with carbon tetrachloride of liver cell carcinomas in hamsters. J. Natl. Cancer Inst. 26(4): 855-863. Edwards, J.E., W.E. Heston and H.A. Dalton. 1942. Induction of the carbon tetrachloride hepatoma in strain L. mice. J. Natl. Cancer Inst. 3: 297-301. NCI (National Cancer Institute). 1976a. Report on the Carcinogenesis Bioassay of Chloroform. National Cancer Institute, Bethesda, MD. March. NCI (National Cancer Institute). 1976b. Carcinogenesis Bioassay of Trichloroethylene. National Cancer Institute Carcinogenesis Technical Report Series, No. 2. NCI-CG-TR-2. February. NCI (National Cancer Institute). 1977. Bioassay of 1,1,1-Trichlorethane for Possible Carcinogenicity. National Cancer Institute Carcinogenesis Technical Report Series, No. 3. NCI-CG-TR-3. January.

A9


A10


A11


D11

OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors California Department of Health Services (CDHS) 1990. Health Effects of Chloroform. Office of Environmental Health Hazard Assessment, Air Toxicology and Epidemiology Section, Berkeley, CA

A12


D12

IRIS Slope Factor reference NTP (National Toxicology Program). 1985. Toxicology and carcinogenesis studies of chlorodibromomethane (CAS No. 124-48-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP Tech. Report Series No. 282. NTIS PB 86-166675.

A13


A14


D14

OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors OEHHA 1992, Expedited Cancer Potency Values and Proposed Regulatory Levels for Certain Proposition 65 Carcinogens.

A15


D15

IRIS Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity. NCI Carcinogenesis Technical Report Series No. 55. DHEW Publ. No. (NIH) 78-1361, Washington DC.

A16


A17


A18


A19


D19

OEHHA, 1999 Public Health Goal for 1,2-Dichloropropane in Drinking Water

A20


D20

IRIS Slope Factor reference NTP (National Toxicology Program). (1985) Toxicology and carcinogenesis studies of Telone II (technical grade 1,3-dichloropropene containing 1% epichlorohydrin as a stabilizer) in F344/N rats and B6C3F1 mice (gavage studies). U.S. Dept. of Health and Human Services, Technical Report Series No. 269.

A21


D21

IRIS Slope Factor reference NCI (National Cancer Insitute). 1978. Bioassay of 1,4-Dioxane for Possible Carcinogenicity, CAS No. 123-91-1. NCI Carcinogenesis Tech. Rep. Ser. No. 80. DHEW Publication No. (NIH) PB-285-711.

A22


A23


A24


A25


A26


A27


A28


A29


A30


A31


A32


D32

IRIS Slope Factor reference NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalaltion studies). NTP-TRS-306. NCA (National Coffee Association). 1983. Twenty-four month oncogenicity study of methylene chloride in mice. Final Report. Prepared by Hazleton Laboratories, America, Inc., Vienna, VA.

A33


A34


D34

IRIS Slope Factor reference NTP (National Toxicology Program). 1983. Carcinogenesis studies of 1,1,1,2- tetrachloroethane (CAS No. 630-20-6) in F344/N rats and B6C3F1 mice (gavage studies). NTP-81-53; NIH Publ. No. 83-1793; NTP Technical Report Series No. 237. NTIS, Springfield, VA.

A35


D35

IRIs Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of 1,1,2,2,-Tetrachloro- ethane for possible carcinogenicity. U.S. Dept. Health, Education and Welfare. Pub. No. (NIH) 78-827).

A36


D36

National Cancer Institute (NCI). 1977. Bioassay of tetrachloroethylene for possible carcinogenicity. Cal/EPA. 2001. Public Health Goal for Tetachloroethylene in Dinking Water, Office of Health Hazard Assessment, California Environmental Protection Agency. http://www.oehha.ca.gov/water/phg/pdf/PCEAug2001.pdf Cal/EPA. 2002. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part II, Technical Support Document for Describing Available Cancer Potency Factors, December 2002, Office of Environmental Health Hazard Assessment, California EPA.

A37


A38


A39


D39

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of 1,1,2-trichloroethane for possible carcinogenicity. U.S. DHEW Tech. Rep. Ser. 74. Publ. No. NCI-CG-TR- 74.

A40


D40

Cal/EPA. 1999. Public Health Goal for Trichloroethylene in Drinking Water, Office of Health Hazard Assessment, California Environmental Protection Agency. http://www.oehha.ca.gov/water/phg/pdf/tce_f.pdf National Cancer Institute (NCI). 1976. Carcinogenesis Bioassay of Trichloroethylene, NCI-CG-TR-2, US Government Printing Office, Washington, DC, DHEW. No. (NIH)75-802. Maltoni C, G Lefemine, and G Cotti. 1986. Archives Of Research On Industrial Carcinogenesis Volume V. Experimental Research On Trichloroethylene Carcinogenesis, (Princeton Scientific Publishing Co., Inc., Prnceton, NJ).

A41


A42


D42

HEAST reference #010849 NTP (National Toxicology Program). 1991. NTP Technical Report On The Toxicology And Carcinogenesis Studies Of 1,2,3-Trichloropropane (CAS No 96-18-4) In F344/N Rats And B6C3F1 Mice (Gavage Studies). Board Draft NTP TR 384. NIH Pub No 91-2839. US Dept Of Health And Human Services, Public Health Service, NIH, Research Triangle Park, NC. UA EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

A43


D43

IRIS Oral Slope Factor reference Feron, V; Hendrikson, CFM; Speek, AJ; et al. (1981) Lifespan oral toxicity study of vinyl chloride in rats. Food Cosmet Toxicol 19:317-333.

A44


A46


A47


A48


D48

IRIS Oral Slope Factor reference Biodynamics, Inc. 1980a. A twenty-four month oral toxicity/carcinogenicity study of acrylonitrile administered to Spartan rats in the drinking water, Vol. 1-2. Prepared by Biodynamics Inc., Division of Biology and Safety Evaluation, East Millstone, NJ, for Monsanto Company, St. Louis, MO. Biodynamics, Inc. 1980b. A twenty-four month oral toxicity/carcinogenicity study of acrylonitrile administered in the drinking water to Fischer 344 rats, Vol. 1-4. Prepared by Biodynamics Inc., Division of Biology and Safety Evaluation, East Millstone, NJ, for Monsanto Company, St. Louis, MO. Quast, J.F., C.E. Wade, C.G. Humiston, R.M. Carreon, E.A. Hermann, C.N. Park and B.A. Schwetz. 1980a. A two-year toxicity and oncogenicity study with acrylonitrile incorporated in the drinking water of rats. Prepared by the Toxicology Research Laboratory, Health and Environmental Sciences, Dow Chemical USA, Midland, MI, for the Chemical Manufacturers Association, Washington, DC. Available from: CMA, Washington DC.

A49


D49

IRIS Oral Slope Factor reference CIIT (Chemical Industry Institute of Toxicology). 1982. 104-Week chronic toxicity study in rats: Aniline hydrochloride. Final report.

A50


A51


D51

IRIS Oral Slope Factor reference Zavon, M.R. 1973. Benzidine exposure as a cause of bladder tumors. Arch. Environ. Health. 27: 1-7.

A52


A53


D53

IRIS Oral Slope Factor reference Neal, J. and R.H. Rigdon. 1967. Gastric tumors in mice fed benzo[a]pyrene -- A quantitative study. Tex. Rep. Biol. Med. 25(4): 553-557.

A54


A55


A56


D56

IRIS Oral Slope Factor reference NTP (National Toxicology Program). 1982. Carcinogenesis bioassay of di-(2-ethylhexyl)phthalate (CAS No. 117-81-7) in F344 rats and B6C3F, mice (feed study). NTP Tech. Rep. Ser. TR No. 217, NTP, Research Triangle Park, NC.

A57


D58

HEAST reference #010096 Tsuda H, A Haziwara, M Shibata, M Oshima, and N Ito. 1982. Carcinogenic Effect Of Carbazole In The Liver Of (C57BL/6N X C3G/HEN)F1 Mice. J Natl Cancer Inst 69: 1383-1389. US EPA. 1986. Health And Environmental Effects Profile For Carbazole. Prepared By The Office Of Health And Environmental Assessment, Environmental Criteria And Assessment Office, Cincinnati, OH For The Office Of Solid Waste And Emergency Response, Washington, DC.

A59


D59

IRIS Slope Factor references IRDC (International Research and Development Corporation). 1973. Eighteen-month oral carcinogenic study of chlordane in mice. Unpublished report to Velsicol Chemical Corporation. MRID No. 00067568. Available from U.S. Environmental Protection Agency. NCI (National Cancer Institute). 1977. Bioassay of chlordane for possible carcinogenicity. Technical Report Series No. 8. U.S. Department of Health, Education and Welfare; National Institutes of Health. PB 271 977. Khasawinah, A.M. and J.F. Grutsch. 1989b. Chlordane: thirty-month tumorigenicity and chronic toxicity test in mice. Regul. Toxicol. Pharmacol. 10(2): 95-109.

A60


A61


A62


A63


D63

OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors OEHHA, 1997 Public Health Goal for 1,4-Dichlorobenzene in Drinking Water

A64


A65


D65

HEAST reference #005050 NTP (National Toxicology Program). 1986. Toxicology And Carcinogenesis Studies Of 1-4-Dichlorobenzene In F344/N Rats And B6C3F1 Mice -- Galley Draft. US DHHS. PHS. NIH Tech Rep Ser No 319. Contaminants. 1987. FR (July 8). 52: 25690-25717.

A66


D66

IRIS Slope Factor reference Stula, E.F., H. Sherman, J.A. Zapp and J.W. Clayton. 1975. Experimental neoplasia in rats from oral administration of 3,3'-dichlorobenzidine, 4,4'- methylene-bis(2- chloroanaline), and 4,4'-methylene-bis(2-methylanaline). Toxicol. Appl. Pharmacol. 31: 159-176.

A67


D67

IRIS Slope Factor reference Tomatis, L., V. Turusov, R.T. Charles and M. Boicchi. 1974. Effect of long- term exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, to 1,1- dichloro-2,2-bis(p-chlorophenyl)-ethane, and to the two chemicals combined on CF-1 mice. J. Natl. Cancer Inst. 52(3): 883-891.

A68


D68

IRIS Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of DDT, TDE and p,p'-DDE for possible carcinogenicity. NCI Report No. 131. DHEW Publ. No. (NIH) 78-1386. Tomatis, L., V. Turusov, R.t. Charles and M. Boicchi. 1974. Effect of long- term exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, to 1,1- dichloro-2,2-bis(p-chlorophenyl)ethane, and the two chemicals combined on CF-1 mice. J. Natl. Cancer Inst. 52: 883-891. Rossi, L., O. Barbieri, M. Sanguineti, J.R.P. Cabral, P. Bruzzi and L. Santi. 1983. Carcinogenicity study with technical-grade DDT and DDE in hamsters. Cancer Res. 43: 776-781.

A69


D69

IRIS Slope Factor reference Turusov, V.S., N.E. Day, L. Tomatis, E. Gati and R.T. Charles. 1973. Tumors in CF-1 mice exposed for six consecutive generations to DDT. J. Natl. Cancer Inst. 51: 983-998. Terracini, B., M.C. Testa, J.R. Cabral and N. Day. 1973. The effects of long-term feeding of DDT to BALB/c mice. Int. J. Cancer. 11: 747-764. Thorpe, E. and A.I.T. Walker. 1973. The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, beta-BHC and gamma-BHC. Food Cosmet. Toxicol. 11: 433-442. Tomatis, L. and V. Turusov. 1975. Studies on the carcinogenicity of DDT. Gann Monograph Cancer Res. 17: 219-241. Cabral, J.R.P., R.K. Hall, L. Rossi, S.A. Bronczyk and P. Shubik. 1982. Effects of long-term intake of DDT on rats. Tumorigenesis. 68: 11-17. Rossi, L., M. Ravera, G. Repetti and L. Santi. 1977. Long-term administration of DDT or phenobarbital-Na in Wistar rats. Int. J. Cancer. 19: 179-185.

A70


A71


A72


A73


D74

IRIS Slope Factor reference Ellis, H.V. III, J.H. Hagensen, J.R. Hodgson, J.L. Minor and C.B. Hong. 1979. Mammalian Toxicity of Munitions Compounds. Phase III. Effects of Lifetime Exposure. Part I. 2,4-Dinitrotoluene. Report Order No. AD-A077692. p. 281.

A75


A76


A77


A78


A79


A80


A81


D81

IRIS Oral Slope Factor reference Davis, K. 1965. Pathology Report on Mice Fed Aldrin, Dieldrin, Heptachlor and Heptachlor Epoxide for Two Years. Internal FDA memorandum to Dr. A.J. Lehman, July 19. Reuber, M.D. 1977. Histopathology of Carcinomas of the Liver in Mice Ingesting Heptachlor or Heptachlor Epoxide. Exp. Cell Biol. 45: 147-157. Epstein, S.S. 1976. Carcinogenicity of heptachlor and chlordane. Sci. Total Environ. 6: 103-154. NCI (National Cancer Institute). 1977. Bioassay of Heptachlor for Possible Carcinogenicity. NCI Carcinogenesis Tech. Rep. Ser. No. 9. (Also published as DHEW Publication No. [NIH] 77-809).

A82


D82

IRIS Oral Slope Factor reference Davis, K.J. 1965. Pathology Report on Mice Fed Aldrin, Dieldrin, Heptachlor and Heptachlor Epoxide for Two Years. Internal FDA memorandum to Dr. A.J. Lehman, July 19. Reuber, M.D. 1977. Histopathology of Carcinomas of the Liver in Mice Ingesting Heptachlor or Heptachlor Epoxide. Exp. Cell Biol. 45: 147-157. Epstein, S.S. 1976. Carcinogenicity of heptachlor and chlordane. Sci. Total Environ. 6: 103-154. Velsicol Chemical Corporation. 1973. MRID No. 00062678. Available from EPA. Write to FOI, EPA, Washington, D.C. 20460.

A83


D83

IRIS Oral Slope Factor reference Erturk, E., R.W. Lambrecht, H.A. Peters, D.J. Cripps, A. Gocmen, C.R. Morris and G.T. Bryan. 1986. Oncogenicity of hexachlorobenzene. In: Hexachlorobenzene: Proc. Int. Symp., C.R. Morris and J.R.P. Cabral, Ed. IARC Scientific Publ. No. 77, Oxford University Press, Oxford. p. 417-423.

A84


D84

IRIS Oral Slope Factor reference Kociba, R.J., D.G. Keyes, G.C. Jersey, et al. 1977. Results of a two-year chronic toxicity study with hexachlorobutadiene in rats. Am. Ind. Hyg. Assoc. J. 38: 589-602.

A85


D85

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of Hexachloroethane for Possible Carcinogenicity. CAS No. 67-72-1. NCI-CG-TR-68. Tech. Report Ser. No. 68. U.S. DHEW. Publ. No. (NIH) 78-1318.

Indeno(1,2,3-c,d)pyrene 193-39-5 B2 Isophorone 78-59-1 C NTP 1986 rat gavage linearized multistage procedure, extra risk preputial gland carcinomaIsopropylbenzene (Cumene) 98-82-8 D Lindane 58-89-9 B2-C Cal/EPAm-cresol 108-39-4 C Methoxychlor 72-43-5 D Methylnaphthalene, 1 - 90-12-0 NANaphthalene 91-20-3 C Nitrobenzene 98-95-3 D

86-30-6 B2 NCI 1979 rat drinking water linearized multistage procedure, extra risk bladder transitional cell carcinomao-cresol 95-48-7 C

117-84-0 D p-cresol 106-44-5 C Pentachlorophenol 87-86-5 B2 NTP 1989 mouse diet linearized multistage procedure liver carcinoma/adenoma, pheochromocytoma, hemangiosarcoma/hemangiomaPhenol 108-95-2 D Polychlorinated Biphenyls 1336-36-3 B2 Norback & Weltman, Brunner et al. 1985, 1996 rat diet linear extrapolation below LED10s liver hepatocellular adenomas, carcinomas, cholangiomas, cholangiocarcinomasPyrene 129-00-0 D Pyridine 110-86-1 NASilvex 93-72-1 NAToxaphene 8001-35-2 B2 Litton Biogenetics 1978 mouse diet linearized multistage procedure, extra risk liver carcinoma, neoplastic nodulesTrichlorophenol, 2,4,5 - 95-95-4 NATrichlorophenol, 2,4,6 - 88-06-2 B2 NCI 1979 rat diet linearized multistage procedure, extra risk blood leukemiaTrimethylbenzene, 1,2,4 - 95-63-6 NATrimethylbenzene, 1,3,5 108-67-8 NATrinitrobenzene, 1,3,5 - (s) 99-35-4 NAVinyl Acetate 108-05-4 NA

Inorganic AnalytesAntimony 7440-36-0 NAArsenic, Inorganic 7440-38-2 A U.S. EPA 1988 human drinking water time & dose related formulation of multistage model skin cancerBarium and Compounds 7440-39-3 D Beryllium and Compounds 7440-41-7 B1 Cadmium 7440-43-9 B1 Chromium (III) (Insoluble Salts) 16065-83-1 D Chromium VI (chronic acid mists) 18540-29-9 A Chromium VI (particulates) 18540-29-9 A Cobalt and Compounds 7440-48-4 B1 Cyanide, Free 57-12-5 D Fluorine (soluble fluoride) 7782-41-4 NAMercury (elemental) 7439-97-6 D Methyl Mercury 22967-92-6 C Nickel (Soluble Salts) 7440-02-0 NASelenium and Compounds 7782-49-2 D Silver 7440-22-4 D Thallium (I) Nitrate 10102-45-1 D Thallium Acetate 563-68-8 D Thallium Carbonate 6533-73-9 D Thallium Chloride 7791-12-0 D Thallium Sulfate 7446-18-6 D Vanadium Pentoxide 1314-62-1 NAVanadium, Metallic 7440-62-2 NAZinc and Compounds 7440-66-6 NA



A86


A87


D87

IRIS Oral Slope Factor reference NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of isophorone (CAS No. 78-59-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP TR-29l. NIH Pub. No. 86-2547.

A88


A89


D89

OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors OEHHA 1992, Expedited Cancer Potency Values and Proposed Regulatory Levels for Certain Proposition 65 Carcinogens.

A90


A91


A93


A94


A95


D95

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1979. Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity. NCI Carcinogenesis Technical Report Series No. 164. NIH 79-1720. NTIS PB 298-275.

A96


A98


A99


D99

IRIS Oral Slope Factor reference NTP (National Toxicology Program). 1989. Technical Report on the Toxicology and Carcinogenesis Studies of Pentachlorophenol (CAS No. 87-86-5) in B6C3F1 mice (Feed Studies). NTP Tech. Report No. 349. NIH Publ. No. 89-2804.

A100


A101


D101

IRIS Oral Slope Factor reference Norback, D.H. and R.H. Weltman. 1985. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Environ. Health Perspect. 60: 97-105. Brunner, M.J., T.M. Sullivan, A.W. Singer, et. al. 1996. An assessment of the chronic toxicity and oncogenicity of Aroclor-1016, Aroclor-1242, Aroclor- 1254, and Aroclor-1260 administered in diet to rats. Study No. SC920192. Chronic toxicity and oncogenicity report. Battelle, Columbus OH.

A102


A103


A104


A105


D105

IRIS Oral Slope Factor reference Litton Bionetics. 1978. Carcinogenic evaluation in mice: Toxaphene. Final report. Prepared by Litton Bionetics, Inc., Kensington, MD for Hercules, Inc., Wilmington, DE. LBI Project No. 20602.

A106


A107


D107

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1979. Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity. U.S. DHEW Publ. No. NCI-CG-TR-155.

A108


A109


A110


A111


A113


A114


D114

IRIS Oral Slope Factor reference U.S. EPA. 1988. Special Report on Ingested Inorganic Arsenic; Skin Cancer; Nutritional Essentiality Risk Assessment Forum. July 1988. EPA/625/3-87/013.

A115


A116


A117


A118


A122


A123


A124


A126


A127


A136


OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)INHALATION AIR UNIT RISK FACTOR TOXICITY METADATA FOR CHEMICALS OF CONCERN

Chemical CAS # EPA Cancer Class Study Reference Study Reference Date Study Species Study Route Extapolation Method Target Organ Tumor Type

Volatile Organic Compounds EPA Cancer ClassificationsAcetone 67-64-1 D A = Human CarcinogenBenzene 71-43-2 A U.S. EPA 1998 human Inhalation low-dose linearity utilizing maximum likelihood estimates blood Leukemia B1 = Probable Human Carcinogen, limited evidence from Carbon Disulfide 75-15-0 NA epidemiologic studiesCarbon Tetrachloride 56-23-5 B2 NCI 1977 hamster/mouse/rat oral exposure linearized multistage procedure, extra risk liver heptocellular carcinomas/hepatomas B2 = Probable Human Carcinogen, "sufficient: evidenceChlorobenzene 108-90-7 D from animal studies and for which there is inadequateChloroethane 75-00-3 NA NCI 1976 mouse oral, gavage linearized multistage procedure, extra risk liver carcinoma evidence or "no data" from epidemiologic studiesChloroform 123-91-1 B2 C = Possible Human CarcinogenDibromochloromethane 67-66-3 C D = Not Classifiable as to Human Carcinogenicity.Dichlorodifluoromethane 124-48-1 NA E = Evidence of Non-Carcinogenicity for HumansDichloroethane, 1,1 - 75-71-8 C NCI 1977 rat/mouse Inhalation time-to-tumor analysis mammary gland adenocarcinomas NA = No Data or Not classifiedDichloroethane, 1,2 - 75-34-3 B2 NTP 1985 mouse oral exposure linearized multistage procedure, extra risk hemangiosarcomasDichloroethene, 1,1 - 107-06-2 C

75-35-4 D 156-59-2 D

Dichloropropane, 1,2 - 156-60-5 B2 Dichloropropene, 1,3 - 78-87-5 B2 Lomax et al. 1989 mouse inhalation linearized multistage procedure, extra risk bronchioalveolar adenomaDioxane, 1,4 - 542-75-6 B2 Ethyl Ether 60-29-7 NAEthylbenzene 100-41-4 D Formaldehyde 50-00-0 B1 Kerns et al. 1983 rat inhalation linearized multistage procedure, extra risk nasal cavity squamous cell carcinomaFormic acid 64-18-6 D

110-54-3 NAIsobutyl Alcohol 78-83-1 NAMethanol 67-56-1 NAMethyl Ethyl Ketone (MEK) 78-93-3 NAMethyl Isobutyl Ketone (MIBK) 108-10-1 NA

1634-04-4 NA Cal/EPA 2002 rat, mice inhalation multistage polynomial multiple sites tumorsMethylene Chloride 75-09-2 B2 NTP 1986 mouse inhalation linearized multistage procedure, extra risk liver, lung adenomas, carcinomasStyrene 100-42-5 NATetrachloroethane , 1,1,1,2 - 630-20-6 C NTP 1983 mouse oral exposure linearized multistage procedure, extra risk liver tumorTetrachloroethane, 1,1,2,2 - 79-34-5 C NCI 1978 mouse oral exposure linearized multistage procedure, extra risk liver carcinomaTetrachloroethene 127-18-4 NA NTP 1986 mouse liver hepatocellular adenomas or carcinomasToluene 108-88-3 NATrichloroethane, 1,1,1 - 71-55-6 D Trichloroethane, 1,1,2 - 79-00-5 C NCI 1978 mouse oral exposure linearized multistage procedure, extra risk liver tumorsTrichloroethene 79-01-6 NA Cal/EPA 2002 mouse inhalation linearized multistage procedure, metabolized dose using PBPK model, geometric mean of unit risks liver, lung, lymph node adenoma, carcinoma, adenocarcinoma, lymphomaTrichlorofluoromethane 75-69-4 NATrichloropropane, 1,2,3 - 96-18-4 B2 Vinyl Chloride 75-01-4 A Maltoni et al. 1981, 1984 rat inhalation linearized multistage, LED 10/linear method liver angiosarcomas, angiomas, hepatomas, neoplastic nodulesXylenes, Total 1330-20-7 NA

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9 NAAcetophenone 98-86-2 D Acrylonitrile 107-13-1 B1 O'Berg 1980 humans inhalation average relative risk respiratory tumorsAniline 62-53-3 B2 Cal/EPAAnthracene 120-12-7 D Benzidine 92-87-5 A Zavon 1973 human inhalation (occupational exposure) one-hit with time factor, extra risk bladder tumorsBenzo(a)anthracene 56-55-3 B2 Benzo(a)pyrene 50-32-8 B2 Benzo(b)fluoranthene 205-99-2 B2 Benzo(k)fluoranthene 207-08-9 B2 Bis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 B2 Cal/EPA 2002 rats, mice diet converted doses to human equivalent doses and used multistage procedureButyl Benzyl Phthalate 85-68-7 C Carbazole 86-74-8 B2Chlordane 57-74-9 B2 Khasawinah and Grutsch 1989 mouse oral exposure linearized multistage procedure, extra risk liver carcinomaChrysene 218-01-9 B2 Dibenz(a,h)anthracene 53-70-3 C Dichlorobenzene, 1,2 - (o) 95-50-1 D Dichlorobenzene, 1,4 - (p) 106-46-7 C NTP 1987 mouse, rat linearized multistage procedure liver carcinomas or adenomas.Dichlorobenzidine, 3,3 - 91-94-1 B2 Stula et al. 1975 rat, dog linearized multistage procedure mammary, liver, bladder adenocarcinoma, leukemia, carcinomaDichlorodiphenyldichloroethane (DDD) 72-54-8 B2 Cal/EPADichlorodiphenyldichloroethene (DDE) 72-55-9 B2 Cal/EPADichlorodiphenyltrichloroethane (DDT) 50-29-3 B2 Tomatis et al. 1974 mouse oral exposure linearized multistage procedure, extra risk liver tumorsDichlorophenoxyacetic acid, 2,4 - 94-75-7 NADiethyl Phthalate 84-66-2 D Dimethylphenol, 2,4 - 105-67-9 NADi-n-butyl Phthalate 84-74-2 D

99-65-0 D Dinitrobenzene, 1,2 - 528-29-0 D Dinitrotoluene, 2,4 - B2 Dinitrotoluene, 2,6 - 121-14-2 NADinitrotoluene Mixture, 2,4/2,6- 606-20-2 B2 Endrin 72-20-8 D Ethylene Glycol 107-21-1 NAFluoranthene 206-44-0 D Fluorene 86-73-7 D Heptachlor 76-44-8 B2 NCI 1977 mouse oral exposure linearized multistage procedure, extra risk liver carcinomasHeptachlor Epoxide 1024-57-3 B2 Velsicol 1973 mouse oral exposure linearized multistage procedure, extra risk liver carcinomaHexachloro- 1,3 - Butadiene 87-68-3 C Kociba et al. 1977 rat oral exposure linearized multistage procedure, extra risk kidney adenomas, adenocarcinomasHexachlorobenzene 118-74-1 B2 Erturk et al. 1986 rat oral exposure linearized multistage procedure, extra risk liver carcinomaHexachloroethane 67-72-1 C NCI 1978 mouse oral exposure linearized multistage procedure, extra risk liver carcinomaIndeno(1,2,3-c,d)pyrene 193-39-5 B2 Isophorone 78-59-1 C Isopropylbenzene (Cumene) 98-82-8 D Lindane 58-89-9 B2-C Thorpe & Walker 1973 mice linearized multistage procedure liver tumorsm-cresol 108-39-4 C Methoxychlor 72-43-5 D Methylnaphthalene, 1 - 90-12-0 NANaphthalene 91-20-3 C Cal/EPANitrobenzene 98-95-3 D

86-30-6 B2 Cardy et al.; Innes et al. 1979; 1969 rat, mice mulistage procedure bladder, liver carcinomas, hepatomas


Hexane, n -




A5


A6


D6

IRIS Inhalation Unit Risk Factor reference Rinsky, RA; Young, RJ; Smith, AB. (1981) Leukemia in benzene workers. Am J Ind Med 2:217-245. Rinsky, RA; Smith, AB; Horning, R; et al. (1987) Benzene and leukemia: an epidemiologic risk assessment. N Engl J Med 316:1044-1050. Paustenbach, D; Bass, R; Price, P. (1993) Benzene toxicity and risk assessment, 1972-1992: implications for future regulation. Environ Health Perspect 101 (Suppl 6):177-200. Crump, KS; Allen, BC. (1984) Quantitative estimates of risk of leukemia from occupational exposure to benzene. Prepared for the Occupational Safety and Health Administration by Science Research Systems, Inc., Ruston, LA. Unpublished Crump, KS. (1994) Risk of benzene-induced leukemia: a sensitivity analysis of the Pliofilm cohort with additional follow-up and new exposure estimates. J Toxicol Environ Health 42:219-242. U.S. EPA. (1998, April 10) Carcinogenic effects of benzene: an update. Prepared by the National Center for Environmental Health, Office of Research and Development. Washington, DC. EPA/600/P-97/001F.

A7


A8


D8

IRIS Slope Factor refeerences Della Porta, G., B. Terracini and P. Shubik. 1961. Induction with carbon tetrachloride of liver cell carcinomas in hamsters. J. Natl. Cancer Inst. 26(4): 855-863. Edwards, J.E., W.E. Heston and H.A. Dalton. 1942. Induction of the carbon tetrachloride hepatoma in strain L. mice. J. Natl. Cancer Inst. 3: 297-301. NCI (National Cancer Institute). 1976a. Report on the Carcinogenesis Bioassay of Chloroform. National Cancer Institute, Bethesda, MD. March. NCI (National Cancer Institute). 1976b. Carcinogenesis Bioassay of Trichloroethylene. National Cancer Institute Carcinogenesis Technical Report Series, No. 2. NCI-CG-TR-2. February. NCI (National Cancer Institute). 1977. Bioassay of 1,1,1-Trichlorethane for Possible Carcinogenicity. National Cancer Institute Carcinogenesis Technical Report Series, No. 3. NCI-CG-TR-3. January.

G8

assuming an air intake of 20 cu.m/day and 40% absorption rate by humans

A9


A10


D10

Inhalation Unit Risk Factor reference National Cancer Institute (NCI). (1976) Report on carcinogenesis bioassay of chloroform. Bethesda, MD: National Cancer Institute.

G10

The unit risk was prepared by taking a geometric mean of the slope factor and assuming 100% for low doses of chloroform in air.

A11


A12


A13


A14


D14

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors Gold L, Slone T, Backman G, Eisenberg S, Da Costa M, Wong M, Manley N and Ames B. 1990. Third chronological supplement to the Carcinogenic Potency Database; Standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987. Environ Health Perspect 84:215-285. National Cancer Institute (NCI) 1977. Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity. CAS No. 75-34-3. Carcinogenesis Technical Report Series No. 66. NCI-CG-TR-66 DHEW Publication No. (NIH) 78-1316. NTIS Publication No. PB-283 345. U.S. Department of Health, Education and Welfare, NCI Carcinogenesis Testing Program, Bethesda, MD. Crump KS, Howe RB, Van Landingham C and Fuller WG. 1991. TOXRISK Version 3. TOXicology RISK Assessment Program. KS Crump Division, Clement International Division, 1201 Gaines Street, Ruston LA 71270.

A15


D15

IRIS Slope Factor reference NTP (National Toxicology Program). 1985. Toxicology and carcinogenesis studies of chlorodibromomethane (CAS No. 124-48-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP Tech. Report Series No. 282. NTIS PB 86-166675.

G15

assuming 100% absorption and metabolism at the low dose

A16


A17


A18


A19


A20


D20

IRIS Inhalation Unit Risk Factor reference Lomax, LG; Stott, WT; Johnson, KA; et al. (1989) The chronic toxicity and oncogenicity of inhaled technical grade 1,3-dichloropropene in rats and mice. Fundam Appl Toxicol 12:418-431.

A21


A22


A23


A24


D24

IRIS Inhalation Unit Risk Factor reference Kerns, W.D., K.L. Pavkov, D.J. Donofrio, E.J. Gralla and J.A. Swenberg. 1983. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res. 43: 4382-4392.

A25


A26


A27


A28


A29


A30


A31


D31

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors Belpoggi F, Soffritti M and Maltoni C. 1998. Pathological characterization of testicular tumours and lymphomas-leukaemias, and of their precursors observed in Sprague-Dawlay rats exposed to methyl tertiary-butyl ether (MTBE). Eur J Oncol 3: 201-206. Belpoggi F, Soffritti M and Maltoni C. 1995. Methyl tertiary-butyl ether (MtBE) - a gasoline additive- causes testicular and lymphohaematopoietic cancers in rats. Toxicol Ind Hlth 11:119-149. Belpoggi F, Soffritti M, Filippini F and Maltoni C. 1997. Results of long-term experimental studies on the carcinogenicity of methyl tert-butyl ether. Annals NY Acad Sci 837: 77-95. Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ and Andrews LS. 1997. Oncogenicity studies of inhaled methyl tertiary-butyl ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol 17(S1): S45-S55. Burleigh-Flayer HD, Chun JS and Kintigh WJ. 1992. Methyl tertiary butyl ether: vapor inhalation oncogenicity study in CD-1 mice. Bushy Run Research Center Report No. 91N0013A. Union Carbide Chemicals and Plastics Company, Inc. submitted to the US EPA under TSCA Section 4 Testing Consent Order 40 CFR 799.5000 with cover letter dated October 29, 1992. EPA/OPTS#42098. Chun JS, Burleigh-Flayer HD and Kintigh WJ. 1992. Methyl tertiary ether: vapor inhalation oncogenicity study in Fisher 344 rats. Bushy Run Research Center Report No. 91N0013B. Union Carbide Chemicals and Plastics Company, Inc. submitted to the United States Environmental Protection Agency under TSCA Section 4 Testing Consent Order 40 CFR 799.5000 with cover letter dated November 19, 1992. EPA/OPTS#42098.

A32


D32

IRIS Inhalation Unit Risk Factor reference NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalaltion studies). NTP-TRS-306.

A33


A34


D34

IRIS Slope Factor reference NTP (National Toxicology Program). 1983. Carcinogenesis studies of 1,1,1,2- tetrachloroethane (CAS No. 630-20-6) in F344/N rats and B6C3F1 mice (gavage studies). NTP-81-53; NIH Publ. No. 83-1793; NTP Technical Report Series No. 237. NTIS, Springfield, VA.

A35


D35

IRIs Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of 1,1,2,2,-Tetrachloro- ethane for possible carcinogenicity. U.S. Dept. Health, Education and Welfare. Pub. No. (NIH) 78-827).

A36


D36

Cal/EPA. 2002. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part II, Technical Support Document for Describing Available Cancer Potency Factors, December 2002, Office of Environmental Health Hazard Assessment, California EPA Cal/EPA. 2001. Public Health Goal for Tetachloroethylene in Dinking Water, Office of Health Hazard Assessment, California Environmental Protection Agency. http://www.oehha.ca.gov/water/phg/pdf/PCEAug2001.pdf

A37


A38


A39


D39

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of 1,1,2-trichloroethane for possible carcinogenicity. U.S. DHEW Tech. Rep. Ser. 74. Publ. No. NCI-CG-TR- 74.

A40


D40

Cal/EPA. 2002. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part II, Technical Support Document for Describing Available Cancer Potency Factors, December 2002, Office of Environmental Health Hazard Assessment, California EPA. Bell ZG, Olson KJ, and Benya TJ. 1978. Final Report of Audit Findings of the Manufacturing Chemists Association (MCA): Administered Trichlorethylene (TCE) Chronic Inhalation Study at Industrial Bio-Test Laboratories, Inc., Decatur, IL,. Unpublished Study Reported In US EPA (1985).

A41


A42


A43


D43

IRIS Inhalation Unit Risk Factor reference Maltoni, C; Lefemine, G; Ciliberti, A; et al. (1981) Carcinogenicity bioassays of vinyl chloride monomer, a model of risk assessment on an experimental basis. Environ Health Perspect 41:3-29. Maltoni, C; Lefemine, G; Ciliberti, A; et al. (1984) Experimental research on vinyl chloride carcinogenesis, Vol. 1 and 2. In: Archives of research on industrial carcinogenesis. Princeton, NJ: Princeton Scientific Publishers, Inc.

A44


A46


A47


A48


D48

IRIS Inhalation Unit Risk Factor reference O'Berg, M. 1980. Epidemiologic study of workers exposed to acrylonitrile. J. Occup. Med. 22: 245-252

A49


D49

OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors

A50


A51


D51

IRIS Inhalation Unit Risk Factor reference Zavon, M.R. 1973. Benzidine exposure as a cause of bladder tumors. Arch. Environ. Health. 27: 1-7.

A52


A53


A54


A55


A56


D56

National Toxicology Program (NTP). 1982. Carcinogenesis bioassay of di-(2-ethylhexyl)phthalate (CAS No. 117-81-7) in F344 rats and B6C3F1 mice (feed study). NTP Tech Rep Ser TR No. 217, NTP, Research Triangle Park, NC.

A57


A59


D59

IRIS Slope Factor references IRDC (International Research and Development Corporation). 1973. Eighteen-month oral carcinogenic study of chlordane in mice. Unpublished report to Velsicol Chemical Corporation. MRID No. 00067568. Available from U.S. Environmental Protection Agency. NCI (National Cancer Institute). 1977. Bioassay of chlordane for possible carcinogenicity. Technical Report Series No. 8. U.S. Department of Health, Education and Welfare; National Institutes of Health. PB 271 977. Khasawinah, A.M. and J.F. Grutsch. 1989b. Chlordane: thirty-month tumorigenicity and chronic toxicity test in mice. Regul. Toxicol. Pharmacol. 10(2): 95-109.

G59

The air unit risk estimate was derived from the oral slope factor because no chronic bioassays have been done via the inhalation route. The human air unit risk is estimated assuming 100% absorption of inhaled chlordane and assuming a breathing rate of 20 cu.m/day.

A60


A61


A62


A63


D63

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors National Toxicology Program (NTP) 1987. Toxicology and Carcinogenesis Studies of 1,4-Dichlorobenzene in F344/N Rats and B6C3F1 Mice. U.S. Department of Health and Human Services, NIH Publication No. 87-2575. Research Triangle Park, NC.

A64


D64

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors Stula EF, Sherman H, Zapp Jr JA, Clayton Jr JW. 1975. Experimental neoplasia in rats from oral administration of 3,3’-dichlorobenzidine, 4,4’-methylene-bis(2-chloroaniline), and 4,4’-methylenebis(2-methylaniline). Toxicol Appl Pharmacol 31:159-176. Stula, E.F., Barnes, J.R., Sherman, H., Reinhardt, C.F., Zapp, J.A., Jr. 1978. Liver and urinary bladder tumors in dogs from 3,3’-dichlorobenzidine. Journal of Environmental Pathology and Toxicology 1:475-490.

A65


D65

USEPA 1997, IRIS database

A66


D66

USEPA 1991, IRIS database

A67


D67

IRIS Slope Factor reference Tomatis, L., V. Turusov, R.T. Charles and M. Boicchi. 1974. Effect of long- term exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, to 1,1- dichloro-2,2-bis(p-chlorophenyl)-ethane, and to the two chemicals combined on CF-1 mice. J. Natl. Cancer Inst. 52(3): 883-891.

A68


A69


A70


A71


A72


A73


A74


A75


A77


A78


A79


A80


A81


D81

IRIS Oral Slope Factor reference Davis, K. 1965. Pathology Report on Mice Fed Aldrin, Dieldrin, Heptachlor and Heptachlor Epoxide for Two Years. Internal FDA memorandum to Dr. A.J. Lehman, July 19. Reuber, M.D. 1977. Histopathology of Carcinomas of the Liver in Mice Ingesting Heptachlor or Heptachlor Epoxide. Exp. Cell Biol. 45: 147-157. Epstein, S.S. 1976. Carcinogenicity of heptachlor and chlordane. Sci. Total Environ. 6: 103-154. NCI (National Cancer Institute). 1977. Bioassay of Heptachlor for Possible Carcinogenicity. NCI Carcinogenesis Tech. Rep. Ser. No. 9. (Also published as DHEW Publication No. [NIH] 77-809).

A82


D82

IRIS Oral Slope Factor reference Davis, K.J. 1965. Pathology Report on Mice Fed Aldrin, Dieldrin, Heptachlor and Heptachlor Epoxide for Two Years. Internal FDA memorandum to Dr. A.J. Lehman, July 19. Reuber, M.D. 1977. Histopathology of Carcinomas of the Liver in Mice Ingesting Heptachlor or Heptachlor Epoxide. Exp. Cell Biol. 45: 147-157. Epstein, S.S. 1976. Carcinogenicity of heptachlor and chlordane. Sci. Total Environ. 6: 103-154. Velsicol Chemical Corporation. 1973. MRID No. 00062678. Available from EPA. Write to FOI, EPA, Washington, D.C. 20460.

A83


D83

IRIS Oral Slope Factor reference Kociba, R.J., D.G. Keyes, G.C. Jersey, et al. 1977. Results of a two-year chronic toxicity study with hexachlorobutadiene in rats. Am. Ind. Hyg. Assoc. J. 38: 589-602.

A84


D84

IRIS Oral Slope Factor reference Erturk, E., R.W. Lambrecht, H.A. Peters, D.J. Cripps, A. Gocmen, C.R. Morris and G.T. Bryan. 1986. Oncogenicity of hexachlorobenzene. In: Hexachlorobenzene: Proc. Int. Symp., C.R. Morris and J.R.P. Cabral, Ed. IARC Scientific Publ. No. 77, Oxford University Press, Oxford. p. 417-423.

A85


D85

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1978. Bioassay of Hexachloroethane for Possible Carcinogenicity. CAS No. 67-72-1. NCI-CG-TR-68. Tech. Report Ser. No. 68. U.S. DHEW. Publ. No. (NIH) 78-1318.

A86


A87


A88


A89


D89

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors Thorpe E and Walker AIT. 1973. The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, b-BHC and g-BHC. Food Cosmet Toxicol 11:433-442.

A90


A91


A93


D93

Air Toxic Hot Spots: Adoption of a Unit Risk Value for Naphthalene http://www.oehha.ca.gov/air/hot_spots/pdf/naphth080304.pdf

A94


A95


D95

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors Cardy RH, Lijinsky W, Hildebrandt PK. 1979. Neoplastic and nonneoplastic urinary bladder lesions induced in Fischer 344 rats and B6C3F1 hybrid mice by N-nitrosodiphenylamine. Ecotoxicol Environ 3:29-35. Innes JRM, Ulland BM, Valerio MG, Petrucelli L, Fishbein L, Hart ER, Pallotta AJ, Bates RR, Falk HL, Gart JJ, Klein M, Mitchell I and Peters J. 1969. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J Natl Cancer Inst 42:1101-1114.

o-cresol 95-48-7 C 117-84-0 D

p-cresol 106-44-5 C Pentachlorophenol 87-86-5 B2 NTP 1989 mice linearized multistage procedure liver, adrenal neoplasmsPhenol 108-95-2 D Polychlorinated Biphenyls 1336-36-3 B2 Norback & Weltman, Brunner et al. 1985, 1996 rat oral exposure linear extrapolation below LED 10s liver hepatocellular adenomas, carcinomas, cholangiomas, cholangiocarcinomasPyrene 129-00-0 D Pyridine 110-86-1 NASilvex 93-72-1 NA Litton Biogenetics 1978 mouse oral exposure linearized multistage procedure, extra risk liver carcinoma, neoplastic nodulesToxaphene 8001-35-2 B2 Trichlorophenol, 2,4,5 - 95-95-4 NA NCI 1979 rat oral exposure linearized multistage procedure, extra risk blood leukemiaTrichlorophenol, 2,4,6 - 88-06-2 B2 Trimethylbenzene, 1,2,4 - 95-63-6 NATrimethylbenzene, 1,3,5 108-67-8 NATrinitrobenzene, 1,3,5 - (s) 99-35-4 NAVinyl Acetate 108-05-4 NA

Inorganic AnalytesAntimony 7440-36-0 NAArsenic, Inorganic 7440-38-2 A Brown and Chu 1983 human inhalation (occupational exposure) absolute-risk linear model lung tumorsBarium and Compounds 7440-39-3 D Beryllium and Compounds 7440-41-7 B1 Wagoner et al. 1980 human inhalation (occupational exposure) relative risk lung tumorsCadmium 7440-43-9 B1 Thun et al. 1985 human inhalation (occupational exposure) two stage; only first affected by exposure; extra risk lung, trachea, bronchus tumorsChromium (III) (Insoluble Salts) 16065-83-1 D Chromium VI (chronic acid mists) 18540-29-9 A Mancuso 1975 human inhalation (occupational exposure) multistage, extra risk lung TumorsChromium VI (particulates) 18540-29-9 A Mancuso 1975 human inhalation (occupational exposure) multistage, extra risk lung TumorsCobalt and Compounds 7440-48-4 B1 NTP 1998 rat and mice lung pulmonary carcinogenesisCyanide, Free 57-12-5 D Fluorine (soluble fluoride) 7782-41-4 NAMercuric Chloride 7487-94-7 D Mercury (elemental) 7439-97-6 C Methyl Mercury 22967-92-6 NANickel (Soluble Salts) 7440-02-0 D Selenium and Compounds 7782-49-2 D Silver 7440-22-4 D Thallium (I) Nitrate 10102-45-1 D Thallium Acetate 563-68-8 D Thallium Carbonate 6533-73-9 D Thallium Chloride 7791-12-0 D Thallium Sulfate 7446-18-6 NAVanadium Pentoxide 1314-62-1 NAVanadium, Metallic 7440-62-2 NAZinc and Compounds 7440-66-6 D


A96


A98


A99


D99

CAL/EPA Reference OEHHA, 2002 Technical Support Document for Describing Available Cancer Potency Factors National Toxicology Program (NTP) 1989. Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures in B6C3F1 Mice. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health.

A100


A101


D101

IRIS Oral Slope Factor reference Norback, D.H. and R.H. Weltman. 1985. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Environ. Health Perspect. 60: 97-105. Brunner, M.J., T.M. Sullivan, A.W. Singer, et. al. 1996. An assessment of the chronic toxicity and oncogenicity of Aroclor-1016, Aroclor-1242, Aroclor- 1254, and Aroclor-1260 administered in diet to rats. Study No. SC920192. Chronic toxicity and oncogenicity report. Battelle, Columbus OH.

A102


A103


A104


D104

IRIS Oral Slope Factor reference Litton Bionetics. 1978. Carcinogenic evaluation in mice: Toxaphene. Final report. Prepared by Litton Bionetics, Inc., Kensington, MD for Hercules, Inc., Wilmington, DE. LBI Project No. 20602.

A105


A106


D106

IRIS Oral Slope Factor reference NCI (National Cancer Institute). 1979. Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity. U.S. DHEW Publ. No. NCI-CG-TR-155.

A107


A108


A109


A110


A111


A113


A114


D114

IRIS Inhalation Unit Risk Factor reference Brown, C.C. and K.C. Chu. 1983a. Approaches to epidemiologic analysis of prospective and retrospective studies: Example of lung cancer and exposure to arsenic. In: Risk Assessment Proc. SIMS Conf. on Environ. Epidemiol. June 28-July 2, 1982, Alta, VT. SIAM Publications. Brown, C.C. and K.C. Chu. 1983b. Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure. J. Natl. Cancer Inst. 70(3): 455-463. Brown, C.C. and K.C. Chu. 1983c. A new method for the analysis of cohort studies: Implications of the multistage theory of carcinogenesis appled to occupational arsenic exposure. Environ. Health Perspect. 50: 293-308. Lee-Feldstein, A. 1983. Arsenic and respiratory cancer in man: Follow-up of an occupational study. In: Arsenic: Industrial, Biomedical, and Environmental Perspectives, W. Lederer and R. Fensterheim, Ed. Van Nostrand Reinhold, New York. Higgins, I. 1982. Arsenic and respiratory cancer among a sample of Anaconda smelter workers. Report submitted to the Occupatinal Safety and Health Administration in the comments of the Kennecott Minerals Company on the inorganic arsenic rulemaking. (Exhibit 203-5) Enterline, P.E. and G.M. Marsh. 1982. Cancer among workers exposed to arsenic and other substances in a copper smelter. Am. J. Epidemiol. 116(6): 895-911.

A115


A116


D116

IRIS Inhalation Unit Risk Factor reference Wagoner, JK; Infante, PF; Bayliss, DL. (1980) Beryllium: an etiologic agent in the induction of lung caner, nonneoplastic respiratory disease, and heart disease among industrially exposed workers. Environ Res 21:15-34.

A117


D117

IRIS Inhalation Unit Risk Factor reference Thun, M.J., T.M. Schnorr, A.B. Smith and W.E. Halperin. 1985. Mortality among a cohort of U.S. cadmium production workers: An update. J. Natl. Cancer Inst. 74(2): 325-333.

D119

IRIS Inhalation Unit Risk Factor reference Mancuso, TF. (1975) Consideration of chromium as an industrial carcinogen. International Conference on Heavy Metals in the Environment, Toronto, Ontario, Canada, October 27-31. pp. 343-356.

D120

IRIS Inhalation Unit Risk Factor reference Mancuso, TF. (1975) Consideration of chromium as an industrial carcinogen. International Conference on Heavy Metals in the Environment, Toronto, Ontario, Canada, October 27-31. pp. 343-356.

A122


A123


A125


A127


A128


A129


A137


OHIO EPA - VOLUNTARY ACTION PROGRAM CHEMICAL INFORMATION DATABASE AND APPLICABLE REGULATORY STANDARDS (CIDARS)VOLUNTARY ACTION PROGRAM SOIL GENERIC NUMERICAL STANDARDS VOLUNTARY ACTION PROGRAM UPUS

MCL UnitsCAS Comm / Ind Soil Std. C/I Single Construction Soil Std. Const. Single Residential Adult Soil Std. Residential Child Soil Std. Soil Saturation Adult Groundwater Child Groundwater VAP UPUS Standard

Number NonCancer Cancer Chem GDCSS NonCancer Cancer Chem GDCSS NonCancer Cancer NonCancer Cancer Chem GDCSS Standard NonCancer Cancer NonCancer Cancer MCL(ug/L) Source

(mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (mg/kg) (ug/L) (ug/L) (ug/L) (ug/L) (ug/L)

Volatile Organic CompoundsAcetone 67-64-1 8.50E+05 NA 1.00E+05 3.20E+05 NA 1.00E+05 3.60E+05 NA 6.40E+04 NA 6.40E+04 1.04E+05 3.40E+04 NA 1.40E+04 NA NA 1.40E+04 Risk Der. Alachlor 2.00 ug / LBenzene 71-43-2 1.70E+02 1.40E+02 1.40E+02 1.50E+02 5.40E+02 1.50E+02 1.20E+02 6.40E+01 9.40E+01 1.90E+02 6.40E+01 9.18E+02 1.40E+02 9.40E+01 5.70E+01 1.30E+02 5.00E+00 5.00E+00 MCL Asbestos 7.00 MFLCarbon Disulfide 75-15-0 2.20E+03 NA 1.40E+03 1.90E+02 NA 1.90E+02 1.60E+03 NA 1.40E+03 NA 1.40E+03 1.38E+03 3.50E+03 NA 1.40E+03 NA NA 1.40E+03 Risk Der. Atrazine 3.00 ug / LCarbon Tetrachloride 56-23-5 8.20E+00 1.50E+01 8.20E+00 2.40E+01 5.60E+01 2.40E+01 6.00E+00 6.60E+00 5.50E+00 2.00E+01 5.50E+00 1.44E+03 2.40E+01 1.10E+01 9.10E+00 1.50E+01 5.00E+00 5.00E+00 MCL Bromate 10.00 ug / LChlorobenzene 108-90-7 7.10E+02 NA 7.10E+02 2.10E+03 NA 7.40E+02 5.10E+02 NA 4.10E+02 NA 4.10E+02 7.37E+02 6.50E+02 NA 2.50E+02 NA 1.00E+02 1.00E+02 MCL Carbofuran 40.00 ug / LChloroethane 75-00-3 1.80E+04 6.80E+04 2.20E+03 5.50E+03 4.70E+05 2.20E+03 1.30E+04 9.50E+03 1.00E+04 3.70E+03 2.20E+03 2.21E+03 1.50E+04 5.50E+02 6.20E+03 7.30E+02 NA 5.50E+02 Risk Der. Chloramines 4000.00 MRDL in ug/LChloroform 67-66-3 6.00E+02 1.40E+01 1.40E+01 4.30E+02 5.50E+01 5.50E+01 4.30E+02 6.60E+00 3.00E+02 2.40E+01 6.60E+00 3.42E+03 3.70E+02 4.00E+01 1.50E+02 4.80E+01 NA 4.00E+01 Risk Der. Chlorine 4000.00 MRDL in ug/LDibromochloromethane 124-48-1 5.90E+04 2.30E+03 1.60E+03 3.90E+05 1.60E+04 1.60E+03 1.30E+04 3.30E+02 1.50E+03 1.30E+02 1.30E+02 1.65E+03 7.60E+02 1.90E+01 3.20E+02 2.50E+01 NA 1.90E+01 Risk Der. Chlorine Dioxide 800.00 MRDL in ug/LDichlorodifluoromethane 75-71-8 5.20E+02 NA 5.20E+02 1.50E+03 NA 1.40E+03 3.90E+02 NA 3.80E+02 NA 3.80E+02 1.36E+03 6.10E+03 NA 2.10E+03 NA NA 2.10E+03 Risk Der. Chlorite 100.00 ug / LDichloroethane, 1,1 - 75-34-3 3.00E+03 NA 2.30E+03 2.50E+03 NA 2.30E+03 2.20E+03 NA 2.00E+03 NA 2.00E+03 2.34E+03 7.00E+03 2.50E+02 2.60E+03 3.20E+02 NA 2.50E+02 Risk Der. Dalapon 200.00 ug / LDichloroethane, 1,2 - 107-06-2 1.70E+04 1.90E+01 1.90E+01 6.60E+03 7.50E+01 7.50E+01 7.50E+03 8.70E+00 1.40E+03 2.70E+01 8.70E+00 2.90E+03 7.50E+02 1.60E+01 3.10E+02 2.00E+01 5.00E+00 5.00E+00 MCL Di(2-ethylhexyl)adipate 400.00 ug / LDichloroethene, 1,1 - 75-35-4 6.10E+02 NA 6.10E+02 1.80E+02 NA 1.80E+02 4.50E+02 NA 4.10E+02 NA 4.10E+02 1.67E+03 1.70E+03 NA 6.80E+02 NA 7.00E+00 7.00E+00 MCL Dibromochloropropane (DBCP) 0.20 ug / L

156-59-2 2.90E+04 NA 2.20E+03 1.90E+05 NA 2.20E+03 6.40E+03 NA 7.60E+02 NA 7.60E+02 2.21E+03 3.80E+02 NA 1.60E+02 NA 7.00E+01 7.00E+01 MCL Dinoseb 7.00 ug / L156-60-5 2.60E+02 NA 2.60E+02 7.80E+01 NA 7.80E+01 1.90E+02 NA 1.80E+02 NA 1.80E+02 1.81E+03 7.10E+02 NA 2.70E+02 NA 1.00E+02 1.00E+02 MCL Diquat 20.00 ug / L

Dichloropropane, 1,2 - 78-87-5 3.10E+01 4.10E+01 3.10E+01 3.00E+01 1.60E+02 3.00E+01 2.30E+01 1.90E+01 2.30E+01 6.00E+01 1.90E+01 1.13E+03 5.20E+02 4.00E+01 1.00E+02 5.10E+01 5.00E+00 5.00E+00 MCL Endothall 100.00 ug / LDichloropropene, 1,3 - 542-75-6 1.30E+02 8.40E+01 8.40E+01 3.80E+01 3.30E+02 3.80E+01 9.50E+01 3.50E+01 9.20E+01 6.60E+01 3.50E+01 8.11E+02 8.60E+02 1.60E+01 2.70E+02 2.10E+01 NA 1.60E+01 Risk Der. Ethylene Dibromide (EDB) 0.05 ug / LDioxane, 1,4 - 123-91-1 1.60E+05 6.00E+02 6.00E+02 8.70E+04 2.30E+03 2.30E+03 5.20E+04 2.60E+02 7.40E+03 5.40E+02 2.60E+02 2.74E+05 3.80E+03 1.40E+02 1.60E+03 1.90E+02 NA 1.40E+02 Risk Der. Glyphosate 700.00 ug / LEthyl Ether 60-29-7 5.90E+05 NA 3.30E+04 3.90E+06 NA 3.30E+04 1.30E+05 NA 1.50E+04 NA 1.50E+04 3.31E+04 7.60E+03 NA 3.20E+03 NA NA 3.20E+03 Risk Der. Haloacetic acids (HAA5) 60.00 ug / LEthylbenzene 100-41-4 8.50E+03 NA 2.30E+02 2.60E+03 NA 2.30E+02 5.90E+03 NA 3.60E+03 NA 2.30E+02 2.34E+02 3.30E+03 NA 1.40E+03 NA 7.00E+02 7.00E+02 MCL Hexachlorocyclopentadiene 50.00 ug / LFormaldehyde 50-00-0 2.90E+03 1.20E+03 1.20E+03 3.50E+03 4.70E+03 3.50E+03 2.10E+03 5.60E+02 1.90E+03 2.10E+03 5.60E+02 1.29E+05 7.60E+03 NA 3.20E+03 NA NA 3.20E+03 Risk Der. Lead 15.00 ug / LFormic acid 64-18-6 1.70E+03 NA 1.70E+03 1.50E+03 NA 1.50E+03 1.20E+03 NA 1.20E+03 NA 1.20E+03 1.72E+05 7.60E+04 NA 3.20E+04 NA NA 3.20E+04 Risk Der. Nitrate - Nitrite (as N) 10000.00 ug / L

110-54-3 8.00E+02 NA 1.90E+02 7.10E+02 NA 1.90E+02 5.90E+02 NA 5.30E+02 NA 1.90E+02 1.86E+02 2.20E+03 NA 9.10E+02 NA NA 9.10E+02 Risk Der. Nitrate (as N) 10000.00 ug / LIsobutyl Alcohol 78-83-1 8.80E+05 NA 4.00E+04 5.80E+06 NA 4.00E+04 1.90E+05 NA 2.30E+04 NA 2.30E+04 4.01E+04 1.10E+04 NA 4.70E+03 NA NA 4.70E+03 Risk Der. Nitrite (as N) 1000.00 ug / LMethanol 67-56-1 2.40E+05 NA 1.10E+05 9.70E+06 NA 1.10E+05 1.30E+05 NA 3.30E+04 NA 3.30E+04 1.06E+05 1.90E+04 NA 7.90E+03 NA NA 7.90E+03 Risk Der. Oxamyl (Vydate) 200.00 ug / LMethyl Ethyl Ketone (MEK) 78-93-3 2.20E+05 NA 1.00E+05 1.50E+04 NA 1.50E+04 1.30E+05 NA 3.70E+04 NA 3.70E+04 1.02E+05 2.20E+04 NA 8.90E+03 NA NA 8.90E+03 Risk Der. Picloram 500.00 ug / LMethyl Isobutyl Ketone (MIBK) 108-10-1 9.70E+04 NA 1.60E+04 1.20E+04 NA 1.20E+04 3.60E+04 NA 5.80E+03 NA 5.80E+03 1.59E+04 3.00E+03 NA 1.20E+03 NA NA 1.20E+03 Risk Der. Simazine 4.00 ug / L

1634-04-4 2.800E+04 1.90E+03 1.90E+03 8.30E+03 7.50E+03 6.70E+03 2.10E+04 8.50E+02 2.10E+04 2.30E+03 8.50E+02 6.74E+03 4.40E+05 8.40E+02 8.40E+04 1.10E+03 4.00E+01 4.00E+01 MCL 2,3,7,8-TCDD (Dioxin) 0.00003 ug / LMethylene Chloride 75-09-2 4.90E+03 5.70E+02 5.70E+02 1.50E+03 2.20E+03 1.50E+03 3.50E+03 2.50E+02 2.20E+03 6.20E+02 2.50E+02 2.30E+03 2.20E+03 2.10E+02 9.20E+02 2.70E+02 5.00E+00 5.00E+00 MCL Total Trihalomethanes 80.00 ug / LStyrene 100-42-5 2.90E+04 NA 1.70E+03 2.70E+04 NA 1.70E+03 2.00E+04 NA 9.50E+03 NA 1.70E+03 1.73E+03 6.70E+03 NA 2.70E+03 NA 1.00E+02 1.00E+02 MCL Trichlorobenzene, 1,2,4 - 70.00 ug / LTetrachloroethane , 1,1,1,2 - 630-20-6 8.80E+04 8.10E+01 8.10E+01 5.80E+04 3.10E+02 3.10E+02 1.90E+04 3.70E+01 2.30E+03 1.10E+02 3.70E+01 7.48E+02 1.10E+03 5.60E+01 4.70E+02 7.00E+01 NA 5.60E+01 Risk Der.Tetrachloroethane, 1,1,2,2 - 79-34-5 1.80E+05 2.40E+01 2.40E+01 9.70E+05 9.40E+01 9.40E+01 3.80E+04 1.10E+01 4.50E+03 2.50E+01 1.10E+01 1.67E+03 2.20E+03 7.00E+00 9.30E+02 9.00E+00 NA 7.00E+00 Risk Der.Tetrachloroethene 127-18-4 1.70E+03 5.30E+01 5.30E+01 5.40E+02 2.20E+02 2.20E+02 1.20E+03 1.80E+01 5.10E+02 1.70E+01 1.70E+01 3.76E+02 3.50E+02 2.60E+00 1.40E+02 3.60E+00 5.00E+00 5.00E+00 MCLToluene 108-88-3 3.30E+04 NA 5.20E+02 2.00E+03 NA 5.20E+02 1.90E+04 NA 5.10E+03 NA 5.20E+02 5.21E+02 2.80E+03 NA 1.20E+03 NA 1.00E+03 1.00E+03 MCLTrichloroethane, 1,1,1 - 71-55-6 1.10E+04 NA 1.30E+03 3.30E+04 NA 1.30E+03 7.80E+03 NA 6.10E+03 NA 1.30E+03 1.34E+03 1.00E+04 NA 4.00E+03 NA 2.00E+02 2.00E+02 MCLTrichloroethane, 1,1,2 - 79-00-5 1.20E+04 5.50E+01 5.50E+01 7.80E+04 2.10E+02 2.10E+02 2.60E+03 2.50E+01 3.00E+02 6.70E+01 2.50E+01 2.55E+03 1.50E+02 2.50E+01 6.30E+01 3.20E+01 5.00E+00 5.00E+00 MCLTrichloroethene 79-01-6 3.20E+03 1.50E+02 1.50E+02 9.60E+02 5.60E+02 5.60E+02 2.40E+03 6.50E+01 2.30E+03 2.00E+02 6.50E+01 9.53E+02 1.60E+04 1.10E+02 5.50E+03 1.50E+02 5.00E+00 5.00E+00 MCLTrichlorofluoromethane 75-69-4 1.60E+03 NA 1.60E+03 4.80E+03 NA 1.60E+03 1.20E+03 NA 1.20E+03 NA 1.20E+03 1.56E+03 1.00E+04 NA 3.80E+03 NA NA 3.80E+03 Risk Der.Trichloropropane, 1,2,3 - 96-18-4 1.80E+04 2.80E+01 2.80E+01 1.20E+05 1.90E+02 1.90E+02 3.80E+03 3.90E+00 4.50E+02 1.50E+00 1.50E+00 1.08E+03 2.30E+02 2.30E-01 9.50E+01 3.00E-01 NA 2.20E-01 Supplemental

Vinyl Chloride 75-01-4 2.10E+02 1.20E+01 1.20E+01 6.30E+01 4.80E+01 4.80E+01 1.50E+02 4.60E+00 9.80E+01 5.90E+00 4.60E+00 1.14E+03 1.10E+02 1.10E+00 4.70E+01 1.50E+00 2.00E+00 2.00E+00 MCLXylenes, Total 1330-20-7 1.50E+03 NA 3.70E+02 4.40E+02 NA 3.70E+02 1.10E+03 NA 1.00E+03 NA 3.70E+02 3.70E+02 3.90E+03 NA 1.30E+03 NA 1.00E+04 1.00E+04 MCL

Semi-Volatile Organic CompoundsAcenaphthene 83-32-9 5.60E+04 NA 5.60E+04 4.40E+05 NA 4.40E+05 2.00E+04 NA 3.50E+03 NA 3.50E+03 na 2.30E+03 NA 9.50E+02 NA NA 9.50E+02 Risk Der.Acetophenone 98-86-2 1.10E+05 NA 1.10E+05 8.50E+05 NA 8.50E+05 3.80E+04 NA 6.30E+03 NA 6.30E+03 na 3.80E+03 NA 1.60E+03 NA NA 1.60E+03 Risk Der.Acrylonitrile 107-13-1 4.80E+01 1.60E+01 1.60E+01 1.40E+01 6.90E+01 1.40E+01 3.50E+01 6.60E+00 3.50E+01 1.10E+01 6.60E+00 2.23E+04 2.60E+02 2.80E+00 5.20E+01 3.70E+00 NA 2.70E+00 Supplemental

Aniline 62-53-3 5.40E+02 7.40E+03 5.40E+02 1.30E+03 4.40E+04 1.30E+03 3.70E+02 2.00E+03 2.20E+02 1.50E+03 2.20E+02 6.21E+04 2.60E+02 2.80E+02 1.10E+02 3.70E+02 NA 1.10E+02 Risk Der.Anthracene 120-12-7 2.80E+05 NA 2.80E+05 2.20E+06 NA 1.00E+06 1.00E+05 NA 1.80E+04 NA 1.80E+04 na 1.10E+04 NA 4.70E+03 NA NA 4.70E+03 Risk Der.Benzidine 92-87-5 3.40E+03 2.90E-01 3.00E-01 2.60E+03 2.50E+00 2.50E+00 1.10E+03 6.30E-02 1.90E+02 4.00E-02 4.00E-02 na 1.10E+02 6.90E-03 4.70E+01 9.20E-03 NA 1.00E-02 Supplemental

Benzo(a)anthracene 56-55-3 NA 7.60E+01 7.60E+01 NA 6.80E+02 6.80E+02 NA 1.80E+01 NA 1.10E+01 1.10E+01 na NA 6.30E-01 NA 1.30E+00 NA 6.30E-01 Supplemental

Benzo(a)pyrene 50-32-8 NA 7.70E+00 7.70E+00 NA 6.90E+01 6.90E+01 NA 1.80E+00 NA 1.10E+00 1.10E+00 na NA 4.60E-02 NA 9.80E-02 2.00E-01 2.00E-01 MCLBenzo(b)fluoranthene 205-99-2 NA 7.70E+01 7.70E+01 NA 6.90E+02 6.90E+02 NA 1.80E+01 NA 1.10E+01 1.10E+01 na NA 4.60E-01 NA 9.90E-01 NA 4.60E-01 Supplemental

Benzo(k)fluoranthene 207-08-9 NA 7.70E+02 7.70E+02 NA 6.90E+03 6.90E+03 NA 1.80E+02 NA 1.10E+02 1.10E+02 na NA 2.20E+01 NA 2.90E+01 NA 2.20E+01 Risk Der.Bis (2-ethylhexyl) Phthalate(BEHP & DEHP) 117-81-7 2.20E+04 4.80E+03 1.90E+02 1.70E+05 4.20E+04 1.90E+02 7.50E+03 1.00E+03 1.30E+03 6.20E+02 1.90E+02 1.90E+02 7.60E+02 1.10E+02 3.20E+02 1.50E+02 6.00E+00 6.00E+00 MCLButyl Benzyl Phthalate 85-68-7 2.20E+05 4.80E+03 5.80E+01 1.70E+06 4.30E+04 5.80E+01 7.50E+04 1.00E+03 1.30E+04 6.20E+02 5.80E+01 5.84E+01 7.60E+03 1.10E+02 3.20E+03 1.50E+02 NA 1.10E+02 Risk Der.Carbazole 86-74-8 NA 3.40E+03 3.40E+03 NA 3.00E+04 3.00E+04 NA 7.30E+02 NA 4.30E+02 4.30E+02 na NA 7.90E+01 NA 1.10E+02 NA 7.90E+01 Risk Der.Chlordane 57-74-9 6.70E+02 2.70E+02 2.70E+02 7.70E+01 1.90E+03 7.70E+01 2.20E+02 5.40E+01 3.40E+01 2.80E+01 2.80E+01 na 1.70E+01 3.90E+00 7.20E+00 5.50E+00 2.00E+00 2.00E+00 MCLChrysene 218-01-9 NA 7.60E+03 7.60E+03 NA 6.90E+04 6.90E+04 NA 1.80E+03 NA 1.10E+03 1.10E+03 na NA 6.30E+01 NA 1.30E+02 NA 6.30E+01 Risk Der.Dibenz(a,h)anthracene 53-70-3 NA 7.70E+00 7.70E+00 NA 6.90E+01 6.90E+01 NA 1.80E+00 NA 1.10E+00 1.10E+00 na NA 1.30E-03 NA 3.10E-03 NA 1.00E-03 Supplemental

Dichlorobenzene, 1,2 - (o) 95-50-1 4.60E+03 NA 3.70E+02 1.20E+04 NA 3.70E+02 3.20E+03 NA 2.30E+03 NA 3.70E+02 3.73E+02 2.80E+03 NA 1.10E+03 NA 6.00E+02 6.00E+02 MCLDichlorobenzene, 1,4 - (p) 106-46-7 1.70E+04 1.30E+02 1.30E+02 1.50E+04 5.10E+02 5.10E+02 1.00E+04 6.00E+01 3.50E+03 2.10E+02 6.00E+01 na 2.30E+03 1.50E+02 9.70E+02 1.70E+02 7.50E+01 7.50E+01 MCLDichlorobenzidine, 3,3 - 91-94-1 NA 1.10E+02 1.10E+02 NA 7.30E+02 7.30E+02 NA 2.80E+01 NA 1.90E+01 1.90E+01 na NA 3.30E+00 NA 4.60E+00 NA 3.30E+00 Supplemental

Dichlorodiphenyldichloroethane (DDD) 72-54-8 4.10E+03 4.70E+02 4.70E+02 2.80E+03 3.50E+03 2.80E+03 1.10E+03 8.70E+01 1.40E+02 4.20E+01 4.20E+01 na 5.10E+01 3.50E+00 2.20E+01 6.00E+00 NA 3.50E+00 Risk Der.Dichlorodiphenyldichloroethene (DDE) 72-55-9 NA 3.10E+02 3.10E+02 NA 2.20E+03 2.20E+03 NA 6.00E+01 NA 3.00E+01 2.90E+01 na NA 2.60E+00 NA 4.40E+00 NA 2.60E+00 Risk Der.Dichlorodiphenyltrichloroethane (DDT) 50-29-3 1.00E+03 3.50E+02 3.50E+02 7.00E+02 2.70E+03 7.00E+02 2.70E+02 6.30E+01 3.60E+01 3.00E+01 3.00E+01 na 1.10E+01 2.00E+00 4.80E+00 3.60E+00 NA 2.00E+00 Risk Der.Dichlorophenoxyacetic acid, 2,4 - 94-75-7 1.10E+04 NA 1.10E+04 8.50E+03 NA 8.50E+03 3.80E+03 NA 6.30E+02 NA 6.30E+02 na 3.80E+02 NA 1.60E+02 NA 7.00E+01 7.00E+01 MCLDiethyl Phthalate 84-66-2 9.00E+05 NA 5.90E+02 6.80E+06 NA 5.90E+02 3.00E+05 NA 5.00E+04 NA 5.90E+02 5.93E+02 3.00E+04 NA 1.30E+04 NA NA 1.30E+04 Risk Der.Dimethylphenol, 2,4 - 105-67-9 2.20E+04 NA 2.20E+04 1.70E+05 NA 1.70E+05 7.50E+03 NA 1.30E+03 NA 1.30E+03 na 7.30E+02 NA 3.10E+02 NA NA 3.10E+02 Risk Der.Di-n-butyl Phthalate 84-74-2 1.10E+05 NA 1.10E+02 8.50E+05 NA 1.10E+02 3.80E+04 NA 6.30E+03 NA 1.10E+02 1.07E+02 3.60E+03 NA 1.50E+03 NA NA 1.50E+03 Risk Der.

99-65-0 1.10E+02 NA 1.10E+02 8.50E+02 NA 8.50E+02 3.80E+01 NA 6.30E+00 NA 6.30E+00 na 3.80E+00 NA 1.60E+00 NA NA 1.60E+00 Supplemental

Dinitrobenzene, 1,2 - 528-29-0 1.10E+02 NA 1.10E+02 8.50E+02 NA 8.50E+02 3.80E+01 NA 6.30E+00 NA 6.30E+00 na 3.80E+00 NA 1.60E+00 NA NA 1.60E+00 Supplemental

Dinitrotoluene, 2,4 - 121-14-2 2.20E+03 9.80E+01 9.80E+01 1.70E+03 8.70E+02 8.70E+02 7.50E+02 2.10E+01 1.20E+02 1.30E+01 1.30E+01 na 7.60E+01 2.30E+00 3.20E+01 3.10E+00 NA 2.30E+00 Risk Der.Dinitrotoluene, 2,6 - 606-20-2 1.10E+03 1.00E+02 1.00E+02 8.60E+03 8.80E+02 8.80E+02 3.80E+02 2.20E+01 6.30E+01 1.30E+01 1.30E+01 na 3.80E+01 2.30E+00 1.60E+01 3.10E+00 NA 2.30E+00 Risk Der.Endrin 72-20-8 3.40E+02 NA 3.40E+02 1.70E+03 NA 1.70E+03 1.10E+02 NA 1.90E+01 NA 1.90E+01 na 1.10E+01 NA 4.60E+00 NA 2.00E+00 2.00E+00 MCLEthylene Glycol 107-21-1 7.60E+05 NA 1.10E+05 1.70E+06 NA 1.10E+05 4.10E+05 NA 1.10E+05 NA 1.10E+05 1.06E+05 7.60E+04 NA 3.20E+04 NA NA 3.20E+04 Risk Der.Fluoranthene 206-44-0 3.70E+04 NA 3.70E+04 2.90E+05 NA 2.90E+05 1.30E+04 NA 2.40E+03 NA 2.40E+03 na 9.60E+02 NA 4.20E+02 NA NA 4.20E+02 Risk Der.Fluorene 86-73-7 3.70E+04 NA 3.70E+04 2.90E+05 NA 2.90E+05 1.30E+04 NA 2.40E+03 NA 2.40E+03 na 1.50E+03 NA 6.30E+02 NA NA 6.30E+02 Risk Der.Heptachlor 76-44-8 5.60E+02 8.90E+00 8.90E+00 8.50E+01 5.20E+01 5.20E+01 1.90E+02 2.40E+00 3.10E+01 1.80E+00 1.80E+00 na 1.80E+01 3.40E-01 7.70E+00 4.60E-01 4.00E-01 4.00E-01 MCLHeptachlor Epoxide 1024-57-3 1.50E+01 7.00E+00 7.00E+00 1.10E+01 5.80E+01 1.10E+01 4.90E+00 1.60E+00 8.10E-01 9.50E-01 8.10E-01 na 4.90E-01 1.70E-01 2.10E-01 2.30E-01 2.00E-01 2.00E-01 MCLHexachloro- 1,3 - Butadiene 87-68-3 2.20E+02 2.40E+02 2.20E+02 1.70E+02 1.10E+03 1.70E+02 7.50E+01 8.30E+01 1.30E+01 9.50E+01 1.30E+01 1.03E+03 6.20E+00 1.50E+01 2.70E+00 2.20E+01 NA 2.70E+00 Supplemental

Hexachlorobenzene 118-74-1 9.00E+02 2.80E+01 2.80E+01 8.50E+01 1.70E+02 8.50E+01 3.00E+02 7.30E+00 5.00E+01 5.20E+00 5.20E+00 na 2.30E+01 6.10E-01 9.70E+00 9.90E-01 1.00E+00 1.00E+00 MCLHexachloroethane 67-72-1 1.10E+03 1.70E+03 1.10E+03 8.50E+03 8.00E+03 8.00E+03 3.80E+02 5.50E+02 6.30E+01 5.50E+02 6.30E+01 na 3.50E+01 1.00E+02 1.50E+01 1.40E+02 NA 1.50E+01 Risk Der.Indeno(1,2,3-c,d)pyrene 193-39-5 NA 7.70E+01 7.70E+01 NA 6.90E+02 6.90E+02 NA 1.80E+01 NA 1.10E+01 1.10E+01 na NA 3.40E-01 NA 7.60E-01 NA 3.40E-01 Supplemental

Isophorone 78-59-1 1.40E+05 7.10E+04 4.60E+03 1.70E+06 6.30E+05 4.60E+03 5.90E+04 1.50E+04 1.20E+04 9.10E+03 4.60E+03 4.57E+03 7.60E+03 1.70E+03 3.20E+03 2.20E+03 NA 1.70E+03 Risk Der.Isopropylbenzene (Cumene) 98-82-8 5.70E+03 NA 2.60E+02 1.70E+04 NA 2.60E+02 4.00E+03 NA 2.70E+03 NA 2.60E+02 2.55E+02 3.60E+03 NA 1.40E+03 NA NA 1.40E+03 Risk Der.Lindane 58-89-9 5.50E+02 7.00E+01 7.00E+01 3.90E+03 4.20E+02 4.20E+02 1.50E+02 1.60E+01 2.10E+01 8.70E+00 8.70E+00 na 1.10E+01 1.40E+00 4.60E+00 1.90E+00 2.00E-01 2.00E-01 MCL

Chemical (Synonyms in comments) Chemicals with MCL's

ONLY (no GDCSS)


Hexane, n -



B3


C3

VAP: The lowest noncancer/cancer value or if the soil saturation value is lower than all values, than that value is assigned as the GNS.

F3

VAP: The lowest noncancer/cancer value or if the soil saturation value is lower than all values, than that value is assigned as the GNS.

M3

VAP: The lowest adult/child noncancer/cancer value or if the soil saturation value is lower than all values, than that value is assigned as the GNS.

T4

VAP: Maximum Contaminant Level

V4

VAP: Either Risk Derived or Based on MCL (or other regulatory Criteria).

A7


A8


D8

carrie rasik: changed 7/31/08 to match run

J8

carrie rasik: Changed 8/01/08 to match run

K8


Q8


S8


Y8

VAP: Million fibers Per Liter.

A9


A10


J10


K10


S10


A11


K11


A12


D12


J12


R12


S12


U12


Y12

VAP: Maximum Residual Disinfectant Level in micrograms per Liter.

A13


D13


J13


U13


Y13


A14


F14


J14


R14


S14


Y14


A15


I15


A16


Q16


S16


U16


A17


D17


J17


P17


A18


A19


C19


F19


K19


A20


F20


A21


D21


R21


S21


A22


D22


J22


L22


P22


S22


U22


A23


D23


F23


K23


L23


A24


F24


R24


U24


A25


K25


A26


D26


J26


R26


U26


X26

VAP: Based on Action Level of 0.015 mg/L.

A27


I27


R27


U27


A28


I28


R28


A29


C29


F29


A30


F30


R30


U30


A31


U31


A32


C32


A33


C33

carrie rasik: changed to match run 7/31/08

D33


F33


I33


J33


K33


T33

arush: adopted from BUSTR

V33

arush: adopted from BUSTR

A34


C34


D34


L34


R34


T34

arush: MCL listed for dichloromethane - synonym for methylene chloride

V34

arush: MCL listed for dichloromethane - synonym for methylene chloride

A35


P35


A36


C36


D36


F36


S36


A37


D37


F37


R37


S37


A38


D38


J38


P38


Q38


S38


A39


A40


K40


A41


D41


F41


L41


R41


A42


J42


R42


S42


A43


A44


D44


F44


G44


J44


R44


U44

VAP: Calculated standard is below detection limit or extremely low to Promulgate.

V44


A45


J45


K45


R45


A46


A48


C48


F48


I48


R48


U48


A49


F49


I49


K49


A50


D50


J50


S50


U50


V50


A51


D51


G51


I51


J51


K51


P51


S51


A52


C52


I52


A53


D53


F53


G53


I53


J53


S53


U53


V53


A54


D54


G54


J54


U54


V54


A55


D55


G55


J55


S55


A56


D56


G56


J56


Q56


S56


U56


V56


A57


D57


G57


J57


S57


A58


D58


G58


I58


J58


K58


L58


R58


V58

VAP: Same as Di(2-ethlyhexyl) Phthalate which has an MCL of 6.0.

A59


D59


G59


I59


J59


K59


L59


R59


D60


G60


J60


L60


S60


A61


C61


D61


F61


G61


I61


J61


Q61


S61


A62


D62


G62


J62


Q62


A63


D63


G63


J63


U63


V63


A64


T64

derr: Standard also Promulgated accidentally

U64

derr: Also has MCL, accidental promulgation of standard

A65


D65


I65


J65


P65


T65

derr: Standard also Promulgated accidentally

V65

derr: Also has MCL, accidental promulgation of standard

A66


D66


G66


J66


S66


U66


V66


A67


D67


F67


G67


I67


J67


Q67


S67


A68


D68


G68


J68


A69


F69


G69


I69


J69


K69


Q69


A70


F70


I70


K70


A71


C71


F71


I71


R71


A72


I72


K72


A73


F73


I73


K73


A74


F74


I74


K74


U74


V74


A75


F75


I75


U75


V75


A76


C76


D76


F76


G76


I76


J76


P76


R76


S76


A77


D77


F77


G77


I77


J77


K77


S77


A78


I78


A79


C79


I79


P79


R79


A80


C80


F80


H80


I80


P80


A81


C81


F81


H81


I81


R81


A82


C82


D82


F82


G82


I82


J82


L82


Q82


S82


A83


D83


G83


I83


J83


K83


L83


Q83


S83


A84


D84


I84


J84


K84


L84


P84


U84


V84


A85


C85


D85


F85


I85


J85


L85


Q85


A86


I86


J86


K86


L86


Q86


A87


D87


G87


J87


Q87


S87


U87


V87


A88


D88


G88


I88


J88


L88


R88


A89


F89


I89


A90


C90


D90


F90


G90


I90


J90


L90


S90


m-cresol 108-39-4 5.60E+04 NA 5.60E+04 4.30E+05 NA 6.10E+04 1.90E+04 NA 3.10E+03 NA 3.10E+03 6.14E+04 1.90E+03 NA 7.90E+02 NA NA 7.90E+02 Risk Der.Methoxychlor 72-43-5 5.60E+03 NA 5.60E+03 4.30E+03 NA 4.30E+03 1.90E+03 NA 3.10E+02 NA 3.10E+02 na 1.90E+02 NA 7.90E+01 NA 4.00E+01 4.00E+01 MCLMethylnaphthalene, 1 - 90-12-0 6.60E+04 NA 3.60E+02 5.10E+04 NA 3.60E+02 2.30E+04 NA 4.10E+03 NA 3.60E+02 3.59E+02 2.60E+03 NA 1.10E+03 NA NA 1.10E+03 Risk Der.Naphthalene 91-20-3 2.80E+02 1.50E+02 1.50E+02 8.40E+01 5.80E+02 8.40E+01 2.00E+02 6.90E+01 1.80E+02 2.60E+02 6.90E+01 na 2.80E+02 1.20E+02 6.70E+01 1.00E+02 NA 6.70E+01 Risk Der.Nitrobenzene 98-95-3 1.70E+02 NA 1.70E+02 6.10E+02 NA 6.10E+02 9.40E+01 NA 2.70E+01 NA 2.70E+01 1.46E+03 1.80E+01 NA 7.00E+00 NA NA 7.00E+00 Supplemental

86-30-6 2.20E+04 1.00E+04 1.00E+04 1.70E+04 7.10E+04 1.70E+04 7.50E+03 2.60E+03 1.30E+03 1.70E+03 1.30E+03 na 7.30E+02 3.00E+02 3.10E+02 4.20E+02 NA 3.00E+02 Risk Der.o-cresol 95-48-7 5.60E+04 NA 5.60E+04 4.30E+05 NA 4.30E+05 1.90E+04 NA 3.10E+03 NA 3.10E+03 na 1.90E+03 NA 7.90E+02 NA NA 7.90E+02 Risk Der.

117-84-0 4.50E+04 NA 1.20E+01 3.40E+05 NA 1.20E+01 1.50E+04 NA 2.50E+03 NA 1.20E+01 1.20E+01 1.50E+03 NA 6.30E+02 NA NA 6.30E+02 Risk Der.p-cresol 106-44-5 5.60E+03 NA 5.60E+03 4.30E+03 NA 4.30E+03 1.90E+03 NA 3.10E+02 NA 3.10E+02 na 1.90E+02 NA 7.90E+01 NA NA 7.90E+01 Risk Der.Pentachlorophenol 87-86-5 1.70E+04 2.80E+02 2.80E+02 4.60E+02 2.60E+03 4.60E+02 6.50E+03 7.10E+01 1.40E+03 5.50E+01 5.50E+01 na 5.60E+02 4.40E+00 2.50E+02 8.60E+00 1.00E+00 1.00E+00 MCLPhenol 108-95-2 6.60E+04 NA 6.60E+04 5.10E+05 NA 5.10E+05 4.00E+04 NA 1.50E+04 NA 1.50E+04 na 1.10E+04 NA 4.70E+03 NA NA 4.70E+03 Risk Der.Polychlorinated Biphenyls 1336-36-3 1.80E+01 2.60E+01 1.80E+01 4.20E+01 2.30E+02 4.20E+01 6.30E+00 6.10E+00 1.20E+00 4.00E+00 1.20E+00 na 7.60E-01 7.90E-01 3.20E-01 1.10E+00 5.00E-01 5.00E-01 MCLPyrene 129-00-0 2.80E+04 NA 2.80E+04 2.20E+05 NA 2.20E+05 1.00E+04 NA 1.80E+03 NA 1.80E+03 na 1.10E+03 NA 4.70E+02 NA NA 4.70E+02 Risk Der.Pyridine 110-86-1 1.10E+03 NA 1.10E+03 8.50E+03 NA 8.50E+03 3.80E+02 NA 6.30E+01 NA 6.30E+01 4.00E+05 3.80E+01 NA 1.60E+01 NA NA 1.60E+01 Risk Der.Silvex 93-72-1 9.00E+03 NA 9.00E+03 6.80E+03 NA 6.80E+03 3.00E+03 NA 5.00E+02 NA 5.00E+02 na 1.30E+02 NA 5.70E+01 NA 5.00E+01 5.00E+01 MCLToxaphene 8001-35-2 NA 5.90E+01 5.90E+01 NA 5.00E+02 5.00E+02 NA 1.30E+01 NA 7.80E+00 7.80E+00 na NA 1.40E+00 NA 1.90E+00 3.00E+00 3.00E+00 MCLTrichlorophenol, 2,4,5 - 95-95-4 1.10E+05 NA 1.10E+05 8.50E+05 NA 8.50E+05 3.80E+04 NA 6.30E+03 NA 6.30E+03 na 3.80E+03 NA 1.60E+03 NA NA 1.60E+03 Risk Der.Trichlorophenol, 2,4,6 - 88-06-2 NA 4.40E+03 4.40E+03 NA 2.90E+04 2.90E+04 NA 1.10E+03 NA 7.70E+02 7.70E+02 na NA 1.20E+02 NA 1.80E+02 NA 1.20E+02 Risk Der.Trimethylbenzene, 1,2,4 95-63-6 1.20E+02 NA 1.20E+02 3.50E+01 NA 3.50E+01 8.70E+01 NA 8.50E+01 NA 8.50E+01 2.55E+02 6.40E+02 NA 1.40E+02 NA NA 1.40E+02 Risk Der.Trimethylbenzene, 1,3,5 108-67-8 9.50E+01 NA 9.50E+01 2.80E+02 NA 2.00E+02 7.00E+01 NA 6.90E+01 NA 6.90E+01 1.99E+02 6.40E+02 NA 1.40E+02 NA NA 1.40E+02 Risk Der.Trinitrobenzene, 1,3,5 - (s) 99-35-4 3.40E+04 NA 3.40E+04 4.30E+02 NA 4.30E+02 1.10E+04 NA 1.90E+03 NA 1.90E+03 na 1.10E+03 NA 4.70E+02 NA NA 4.70E+02 Risk Der.Vinyl Acetate 108-05-4 2.00E+03 NA 2.00E+03 1.00E+02 NA 1.00E+02 1.50E+03 NA 1.40E+03 NA 1.40E+03 2.71E+03 1.80E+04 NA 4.30E+03 NA NA 4.30E+03 Risk Der.

Inorganic AnalytesAntimony 7440-36-0 1.20E+03 NA 1.20E+03 3.90E+02 NA 3.90E+02 2.60E+02 NA 3.00E+01 NA 3.00E+01 NA 1.50E+01 NA 6.30E+00 NA 6.00E+00 6.00E+00 MCLArsenic, Inorganic 7440-38-2 6.10E+02 8.20E+01 8.20E+01 4.20E+02 6.40E+02 4.20E+02 1.60E+02 1.40E+01 2.10E+01 6.70E+00 6.70E+00 NA 1.10E+01 1.10E+00 4.70E+00 1.40E+00 1.00E+01 1.00E+01 MCLBarium and Compounds 7440-39-3 3.70E+05 NA 3.70E+05 1.20E+05 NA 1.20E+05 1.10E+05 NA 1.50E+04 NA 1.50E+04 NA 7.60E+03 NA 3.20E+03 NA 2.00E+03 2.00E+03 MCLBeryllium and Compounds 7440-41-7 5.10E+03 3.90E+04 5.10E+03 3.10E+03 6.30E+04 3.10E+03 1.20E+03 1.60E+04 1.50E+02 6.30E+04 1.50E+02 NA 5.50E+01 NA 2.40E+01 NA 4.00E+00 4.00E+00 MCLCadmium 7440-43-9 2.30E+03 5.20E+04 2.30E+03 1.60E+03 8.30E+04 1.60E+03 5.70E+02 2.20E+04 7.20E+01 8.30E+04 7.20E+01 NA 1.80E+01 NA 7.50E+00 NA 5.00E+00 5.00E+00 MCLChromium (III) 16065-83-1 4.40E+06 NA 1.00E+06 2.90E+06 NA 1.00E+06 9.60E+05 NA 1.10E+05 NA 1.10E+05 NA 4.70E+04 NA 2.00E+04 NA NA NA NAChromium (VI) 18540-29-9 8.40E+03 7.90E+03 7.90E+03 1.50E+04 1.30E+04 1.30E+04 1.90E+03 3.30E+03 2.30E+02 1.30E+04 2.30E+02 NA 9.40E+01 NA 4.00E+01 NA NA NA NAChromium (Total) NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA 1.00E+02 1.00E+02 MCLCobalt 7440-48-4 2.30E+04 3.40E+04 2.30E+04 4.00E+03 5.40E+04 4.00E+03 8.60E+03 1.40E+04 1.40E+03 5.40E+04 1.40E+03 NA 7.60E+02 NA 3.20E+02 NA NA 3.20E+02 Risk Der.Cyanide, Free 57-12-5 5.90E+04 NA 5.90E+04 3.90E+04 NA 3.90E+04 1.30E+04 NA 1.50E+03 NA 1.50E+03 NA 7.60E+02 NA 3.20E+02 NA 2.00E+02 2.00E+02 MCLFluorine (soluble fluoride) NA 1.80E+05 NA 1.80E+05 1.20E+05 NA 1.20E+05 3.90E+04 NA 4.50E+03 NA 4.50E+03 NA 2.30E+03 NA 9.50E+02 NA 4.00E+03 4.00E+03 MCLMercury 7439-97-6 2.90E+02 NA 2.90E+02 1.90E+02 NA 1.90E+02 6.40E+01 NA 7.60E+00 NA 7.60E+00 NA 3.80E+00 NA 1.60E+00 NA 2.00E+00 2.00E+00 MCLNickel (Soluble Salts) Various 4.40E+04 NA 4.40E+04 2.10E+04 NA 2.10E+04 1.20E+04 NA 1.50E+03 NA 1.50E+03 NA 7.60E+02 NA 3.20E+02 NA NA 3.20E+02 Risk Der.Selenium and Compounds 7782-49-2 1.50E+04 NA 1.50E+04 9.70E+03 NA 9.70E+03 3.20E+03 NA 3.80E+02 NA 3.80E+02 NA 1.90E+02 NA 7.90E+01 NA 5.00E+01 5.00E+01 MCLSilver 7440-22-4 1.50E+04 NA 1.50E+04 9.70E+03 NA 9.70E+03 3.20E+03 NA 3.80E+02 NA 3.80E+02 NA 1.90E+02 NA 7.90E+01 NA NA 7.90E+01 Risk Der.Thallium 7440-28-0 2.30E+02 NA 2.30E+02 1.60E+03 NA 1.60E+03 5.10E+01 NA 6.10E+00 NA 6.10E+00 NA 3.00E+00 NA 1.30E+00 NA 2.00E+00 2.00E+00 MCLVanadium 7440-62-2 2.60E+04 NA 2.60E+04 1.70E+04 NA 1.70E+04 5.80E+03 NA 6.80E+02 NA 6.80E+02 NA 3.10E+02 NA 1.30E+02 NA NA 1.30E+02 Risk Der.Zinc and Compounds 7440-66-6 8.80E+05 NA 8.80E+05 5.80E+05 NA 5.80E+05 1.90E+05 NA 2.30E+04 NA 2.30E+04 NA 1.10E+04 NA 4.70E+03 NA NA 4.70E+03 Risk Der.

Supplemental Criteria2-methylnaphthalene 91-57-6 3.70E+03 NA 3.70E+03 2.80E+03 NA 2.80E+03 1.30E+03 NA 2.40E+02 NA 2.40E+02 na 1.50E+02 NA 6.30E+01 NA NA 6.30E+01 Supplemental

4-chlorotoluene 106-43-4 2.20E+04 NA 2.30E+02 1.70E+05 NA 2.30E+02 7.50E+03 NA 1.30E+03 NA 2.30E+02 2.30E+02 7.60E+02 NA 3.20E+02 NA NA 3.20E+02 Supplemental

Acenaphthylene 208-96-8 5.60E+04 NA 5.60E+04 4.40E+05 NA 4.40E+05 2.00E+05 NA 3.50E+03 NA 3.50E+03 na 2.30E+03 NA 9.50E+02 NA NA 9.50E+02 Supplemental

Benzo(g,h,i)perylene 191-24-2 2.80E+04 NA 2.80E+04 2.20E+05 NA 2.20E+05 9.90E+03 NA 1.80E+03 NA 1.80E+03 na 1.10E+03 NA 4.70E+02 NA NA 4.70E+02 Supplemental

Copper 7440-50-8 1.20E+05 NA 1.20E+05 1.90E+04 NA 1.90E+04 2.60E+04 NA 3.00E+03 NA 3.00E+03 na 1.50E+03 NA 6.30E+02 NA NA 1.50E+03 MCLGDimethyl phthalate 131-11-3 9.00E+05 NA 5.68E+03 6.80E+06 NA 5.68E+03 3.00E+05 NA 5.00E+04 NA 5.68E+03 5.68E+03 3.00E+04 NA 1.30E+04 NA NA 1.30E+04 Supplemental

Dioxin (2,3,7,8-TCDD) 1746-01-6 2.00E-03 8.90E-04 8.90E-04 1.30E-03 6.20E-03 1.30E-03 4.00E-04 3.40E-05 3.90E-04 3.40E-05 3.40E-05 na 3.00E-05 3.00E-05 MCLGMethyl butyl ketone 591-78-6 9.00E+04 NA 9.00E+04 6.80E+05 NA 6.80E+05 3.00E+04 NA 5.00E+03 NA 5.00E+03 na 3.00E+03 NA 9.50E+02 NA NA 9.50E+02 Supplemental

n-butyl benzene 104-51-8 5.20E+04 NA 1.78E+02 6.30E+03 NA 1.78E+02 2.30E+04 NA 4.70E+03 NA 1.78E+02 1.78E+02 3.00E+03 NA 1.30E+03 NA NA 1.30E+03 Supplemental

n-propyl benzene 103-65-1 5.80E+03 NA 2.36E+02 1.70E+04 NA 2.36E+02 4.00E+03 NA 2.70E+03 NA 2.36E+02 2.36E+02 3.60E+03 NA 1.40E+03 NA NA 1.40E+03 Supplemental

Phenanthrene 85-01-8 2.80E+05 NA 2.80E+05 2.20E+06 NA 2.20E+06 9.90E+04 NA 1.80E+04 NA 1.80E+04 na 1.10E+04 NA 4.70E+03 NA NA 4.70E+03 Supplemental

p-isopropyltoluene (Cymene) 99-87-6 2.20E+05 NA 5.73E+02 1.70E+05 NA 5.73E+02 7.50E+04 NA 1.30E+04 NA 5.73E+02 5.73E+02 7.60E+03 NA 3.20E+03 NA NA 3.20E+03 Supplemental

Sec-butyl benzene 135-98-8 6.20E+04 NA 7.64E+02 1.00E+04 NA 7.64E+02 2.50E+04 NA 4.80E+03 NA 7.64E+02 7.64E+02 3.00E+03 NA 1.30E+03 NA NA 1.30E+03 Supplemental

Tert-butyl benzene 98-06-6 4.60E+04 NA 2.15E+02 4.80E+03 NA 2.15E+02 2.10E+04 NA 4.70E+03 NA 2.15E+02 2.15E+02 3.00E+03 NA 1.30E+03 NA NA 1.30E+03 Supplemental



A91


C91


F91


I91


U91


A92


C92


F92


I92


C93


F93


I93


P93


A94


D94


G94


J94


L94


Q94


S94


A95


I95


U95


V95


A96


F96


G96


I96


J96


K96


L96


R96


S96


A97


C97


F97


I97


R97


U97


C98


F98


I98


R98


U98


A99


C99


F99


I99


R99


U99


A100


D100


F100


I100


J100


L100


Q100


R100


A101


F101


I101


A102


D102


F102


I102


J102


L102


P102


Q102


S102


A103


C103


F103


I103


A104


I104


K104


A105


C105


F105


I105


R105


A106


D106


G106


J106


L106


S106


A107


F107


I107


K107


A108


D108


J108


L108


Q108


S108


A109


I109


A110


A111


F111


I111


A112


P112


A114


F114


R114


A115


C115


D115


F115


G115


I115


J115


L115


U115

VAP: On January 22, 2001 EPA published the revised arsenic MCL from 50.0 ug/L to 10.0 ug/L and will become effective/enforcable on January 23, 2006. Analytical methods (EPA Method 200.7) and (SM 3120 B) will not be appropriate to be used in the compliance determination due to the method detection limits exceeding the revised MCL.

A116


D116


G116


J116


R116


A117


D117


J117


L117


A118


C118


D118


F118


G118


I118


J118


L118


A119


F119


I119


U119

VAP: Promulgated Chromium (total).

A120


C120


D120


J120


U120

VAP: Promulgated Chromium (total).

D122


I122


R122


U122


A123


F123


R123


A124


F124


R124


A125


C125


F125


K125


A126


R126


A127


F127


R127


A128


F128


R128


F129


K129


R129


C130


A131


C131


F131


C133


E133


F133


H133


I133


R133


U133

VAP: Didn't Promulgate UPUS on Supplementals.

V133


I134


K134


R134


U134


V134


A135


C135


E135


I135


R135


U135


V135


A136


C136


E136


F136


H136


I136


U136


V136


F137


H137


R137


U137

VAP: As per MCL action Level of 1.3 mg/L.

V137

VAP: EPA MCL action level.

A138


C138


E138


F138


H138


I138


R138


U138


V138


A139

carrie rasik: soil values added july 2010- crystal ball runs performed by Audrey

P139

VAP: cell left blank because UPUS standard is an EPA MCL action level.

Q139


R139


S139


T139


U139


V139


C140


E140


F140


H140


I140


R140

VAP: revised to match '07 generic standards crystal ball final run

U140


V140


C141


I141


R141


U141


V141


I142


U142


V142


A143


C143


E143


F143


H143


I143


U143


V143


I144


K144


R144


U144


V144


C145


I145


R145


U145


V145


I146


R146


U146


V146


[XLS] Database.xls · Web viewGeneric Numerical Standards Inhalation URF Metadata Oral SLope Factor...

Documents

Transcript of [XLS] Database.xls · Web viewGeneric Numerical Standards Inhalation URF Metadata Oral SLope Factor...