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WWW.LMP.FACMED.UTORONTO.CA Vol. 14 #3– 2012

LMPAnnual Reunion & Banquet. From (top) left to right: Katie Babcock, Dr. Richard Hegele, Christine Kreutzer, Rama Ponda, Zamiha Premji,

(seated) Teresa Trimboli, Robin Wilcoxen, Louella D’Cunha, Joanne D’Angelo, Paula Nixon & Sue Sarju Balaga

COMMENTS FROM THE CHAIR INVESTIGATING DISEASE. IMPACTING HEALTHCARE.

The Department of Laboratory Medicine and Pathobiology (LMP) occupies a special place at the interface between basic biomedical science and healthcare. This location provides an incredible opportunity to make major advances in understanding of the causes and mechanisms of disease and translating new knowledge into improved health outcomes for patients and populations.

As part of the implementation of the LMP Strategic Plan 2010-2015, we held the “LMP Tagline Challenge”, in which the entire department was invited to submit suggestions for a concise and memorable turn of phrase that embodies the mission and aspirations of LMP. I was personally overwhelmed by the response—over 200 entries were submitted for a chance to win an iPad 3. One cannot help but be impressed by the level of engagement shown by our faculty,

students, trainees and staff. Congratulations to Ghassan Awad Elkarim, one of our students in the Undergraduate Arts and Science Pathobiology Specialist Program, on winning the iPad 3. It bodes well for the future of our department to have someone at such an early stage understand what LMP is all about!

The 2011-12 academic year has been marked by consistent high level performance and accomplishment in the spheres of education, research, creative professional activity and service. Objective evidence for this can be found in the diversity of LMP faculty who were promoted to the rank of Full Professor at the University of Toronto during the most recent promotions cycle. Congratulations to Drs. Hong Chang, Michael Ohh and Patricia Shaw on their promotions.

Inside This Issue: Awards & Honors……..pg 2 Appointments………….pg 3 Announcements……….pg 4 Research……………….pg 4 Education……………….pg 5 Hospital Reports……….pg 7 Publications………….…pg 11 Photos…………………..pg 16

LMP NEWS - Laboratory Medicine & Pathobiology, University of Toronto Vol. 14 #3- 2012

Excellence & Innovation in Academic Laboratory Medicine & Pathology ● ww.lmp.facmed.utoronto.ca 2

Starting this fall, each LMP faculty member who is promoted to Full Professor will deliver a “Professorial Lecture” to the whole department, as part of the LMP Weekly Seminar Series held on Monday afternoons at 4 p.m. I guarantee you will be impressed by the incredible accomplishments of these individuals and their fascinating stories that resulted in each of them achieving an international reputation with distinction.

LMP does not take the summer off. Our Summer Student program is well subscribed and students get the opportunity to work with exceptional faculty on a wide range of projects. The LMP Summer Student Research Day is scheduled for August 16th and everyone is invited to attend and view the posters and interact with the students who have worked so hard over their term. I know you will be amazed by the quantity and quality of research occurring throughout the department and the caliber of students.

Investigating Disease. Impacting Healthcare. LMP focuses on real solutions to real problems. That’s what makes our department such a special place and thanks to all who contribute to advancing our mission.

With best wishes for the summer.

Richard G. Hegele, MD, FRCPC, PhD Professor and Chair

AWARDS AND HONORS

LMP 2012 ANNUAL REUNION & BANQUET Allan Gornall Testimonial Award Qi Jiang

Allan Pollard Postdoctoral Clinical Chemistry Travel Award Julie Shaw

Danny Ghazarian Resident Teaching Award Scott Boerner & Alden Chesney

Distinguished Service Award Tony Mazzulli

Graduate Teaching/Education Award Terence Colgan

Harry Gotlieb Award in Undergraduate Medical Pathology Larissa Liontos

John B. Walter Teaching Prize George Yousef

Linda & Avrum Gotlieb Award Tao (Tony) Liu

Norman Bethune Award Julianne Kus

Stuart Allan Hoffman Memorial Prize Andrea Conroy

Third Year Specialist Pathobiology Award Michael Wong

Undergraduate Teaching/Education Award Heyu Ni

Wolfgang Vogel Memorial Travel Award Nicole White

FACULTY Khosrow Adeli has been awarded the 2012 Canadian

Society of Clinical Chemist Award.

Sahar Al-Haddad received the Dr. Arthur Vandenbroucke Award for Teaching to Laboratory Technologists and Technicians from the Department of Laboratory Medicine at St. Michael’s Hospital.

Jagdish Butany received the 2011 Colin Woolf Award for Longterm Contributions to Continuing Education. The award recognizes and promotes the importance of innovative research in continuing education for health professionals.

Terence Colgan was awarded the President’s Meritorious Award for service to the American Society of Colposcopy and Cervical Pathology at the Society’s Biennial meeting in San Francisco on March 17th, 2012.

Eleftherios Diamandis has been honoured as a Fellow of the American Association for the Advancement of Science for his contributions to the field of genomics and pathobiology of serine proteases, particularly the kallikrein family, and their application as diagnostic cancer biomarkers.

Richard Hegele received the Award of Merit from the Society for Cardiovascular Pathology.

Jason Karamchandani is the recipient of the Teaching Award for Excellence in PBL Teaching from the FitzGerald Academy

Jeffrey Lee received the 2012 Connaught New Researcher Award.

Donald Low was presented with a Council Award. Dr. Low's research group is recognized internationally for their Canadian population-based surveillance programs for the study of antimicrobial resistance and infectious diseases.

Larissa Matukas received the Dr. Bernadette Garvey Award for Teaching to Residents, Graduate Students and Fellows from the Department of Laboratory Medicine at St. Michael’s Hospital.

Katerina Pavenski received the Dr. Kalman Kovacs Award for Teaching to Undergraduate Medical Students from the Department of Laboratory Medicine at St. Michael’s Hospital.

Douglas Templeton is the recipient of the 2012 Excellence in Undergraduate Teaching in the Life Sciences Award. The award recognizes sustained excellence in teaching, coordination, and/or development lecture or seminar courses in Arts and Science offered by the Basic Sciences Departments in the Faculty of Medicine.

Ming-Sound Tsao has been awarded the Canadian Cancer Society's O. Harold Warwick Prize.

Dan Winer received the Dr. Hubert Wolfe Award in Endocrine Pathology.

STUDENTS AND TRAINEES Jennifer Sacco, MSc won second place in the 2012

Laurence Becker Symposium Poster Competition.

Alberta Innovates Health Solutions Clinical Fellowship Incentive Award Vijay Ramaswamy (Michael Taylor)

CIHR CGS Doctoral Pawel Buczkowicz (Cynthia Hawkins)



CIHR Doctoral Research Award Eric Shikatani (Husain Mansoor)

CIHR Fellowship Vijay Ramaswamy (Michael Taylor)

CIHR Vanier Canada Graduate Scholarship Xin Kevin Wang (Michael Taylor) Jayesh Salvi (Karim Mekhail) Samantha Greer (Michael Ohh)

Gordon Cressy Student Leadership Master’s Award Nisa Mullaithilaga (Chen Wang)

Graduate Student Research Day 2012 Award Winners

MSc: Patrick Mott (Alan Lazarus) Nadia Okolowsky (Paul Hamel) Andrea Savio (Bharati Bapat) Alex Tam (Yeni Yucel)

PhD: Olga Brashavitskaya (Carol Swallow) Alexander Falkenhagen (Sadhna Joshi) Nisha Kanwar (Susan Done) Paul Nagy (Isabelle Aubert) Punit Saraon (Eleftherios Diamandis) Bunty Singh (Ren Ke Li) Joanna Smeeton (Norman Rosenblum)

NSERC CGS Master’s Tayyaba Jiwani (Norman Rosenblum)

Queen Elizabeth II Graduate Scholarship in Science and Technology – Heat and Stroke Foundation of Ontario Marsel Lino (Khosrow Adeli) Allan Siu (Myron Cybulsky)

University of Toronto Fellowship Farshad Azimi (Jeff Lee) Brian Golbourn (James Rutka) John Lee (Philip Marsden) Michael Norris (Theo Moraes) Jonathan Torchia (Annie Huang)

Postgraduate Trainee 2012 Research Day:

Clinical Awards First Place: Michael Sidiropoulos Second Place: Manal Tadros Third Place: Shawn Winer Research Awards First Place: Nicole White Second Place: Julianne Kus Third Place: Andrei Drabovich

APPOINTMENTS CLAMPS EXECUTIVE COUNCIL 2012-2013 President: Stephen McCarthy Vice-President Academic: Eric Shikatani Vice-President Social: Evgenia Bloch Secretary: Henry Cheng Treasurer: Ekaterina Olkhov

LMPSU EXECUTIVE COUNCIL 2012-2013 President: Desmond She Vice President Academic: Ghassan El-Karim Vice-President Financial: William Fung Vice-President Social Coordinator: Anastasia Bosc Communications Officers: Darren Benedict, David Dai, Carl Ren Social Committee: Florence Chen, Jennifer Lee, Tom Lu

LMP NEW STAFF APPOINTMENTS We have 8 new faculty members who have joined the Department:

Cameron Ackerley The Hospital for Sick Children Rank: Lecturer Effective: February 1, 2012

Shelley Boyd St. Michael’s Hospital Rank: Assistant Professor Effective: March 1, 2012

Matthew Cesari Sunnybrook Health Sciences Centre Rank: Assistant Professor Effective: May 1, 2012

David Farrell Ontario Agency for Health & Promotion Rank: Associate Professor Effective: April 1, 2012

Mary Ann George The Hospital for Sick Children Rank: Assistant Professor Effective: March 1, 2012

Guangming Han Sunnybrook Health Sciences Centre Rank: Assistant Professor Effective: March 15, 2012

Michael Pickup Ontario Forensic Pathology Service Rank: Assistant Professor Effective: February 1, 2012

Michael Roehrl Toronto General Hospital (UHN) Rank: Associate Professor Effective: June 1, 2012

Kun-Young Sohn Credit Valley Hospital for Sick Children Rank: Lecturer Effective: March 1, 2012

LMP STAFF PROMOTIONS

Hong Chang Rank: Professor Effective: July 1, 2012

Lili-Naz Hazrati Rank: Assistant Professor Effective: May 3, 2012

Michael Ohh Rank: Professor Effective: July 1, 2012

Nades Palaniyar Rank: Associate Professor Effective: July 1, 2012

Patricia Shaw Rank: Professor Effective: July 1, 2012



ANNOUNCEMENTS

LMP Tagline Winner

Ghassan Awad Elkarim with his iPad 3

Ghassan: “LMP is not only a program that I am enrolled in, but also a family that I am happy to be a part of!”

Eleftherios Diamandis has been elected to Fellowship in the Canadian Academy of Health Sciences.

Avrum Gotlieb has been approved by the Academic Board of his extension as Acting Vice Dean, Graduate Affairs. Dr. Gotlieb will continue in this role until December 31, 2012.

Golnar Rasty has been appointed as an Executive Committee Member at Iranian Pathology Association of North America; a subcommittee of USCAP.

Gino Somers has been appointed as Chair of the Pathology and Molecular Diagnostics Committee, for the Pediatric Oncology Group of Ontario.

Linda Sugar has been appointed as PGME Accreditation Consultant.

Glenn Taylor was named President Elect of the Society for Pediatric Pathology on March 18, 2012.

LMP ADMINISTRATIVE ANNOUNCEMENTS Welcome to Katie Babcock who has joined the LMP

Administrative Team as our Web and Communications Coordinator, for a two year term, on April 9th.

SEMINARS / COURSES / ROUNDS Mondays Postgraduate Seminars/Recent Advances in

Pathology, 2-4 PM, TGH, Pathology Conference Rm, 11th Flr, Eaton Wing. Graduate Student Presentation Seminars, 3-4 PM, MSB

2172. LMP Seminars in Molecular Pathobiology, 4-5 PM, MSB

2172. Tuesdays Postdoctoral Training Program Journal Club, 11-1 PM,

MSH 6-412.

Wednesdays Hematopathology Review, 9-10 AM, MSH 6-412 (1st

Wednesday of the month). Hematopathology Journal Club/Critical Appraisal, 9-10

am, MSH 6-412 (2nd Wednesday of the month). Hematopathology Interesting Cases, 9-10 am, MSH 6-

412 (3rd Wednesday of the month). Thursdays University of Toronto Transfusion Rounds, 12-1 PM, (3rd

Thursday of the month). Check website for venue details at www.transfusionontario.org.

Fridays The Centre for Forensic Science & Medicine 2011/12

Seminar Series: Controversies in Forensic Science and Medicine: Towards Resolution in the 21st Century. 1:30-3:00 PM, Health Science Centre, 155 College St. Rm. 106. (last Friday of the month from November–May). www.forensics.utoronto.ca/events

Surgical Pathology Update in Kuwait 2012

In April, Surgical Pathology Update was a success in Kuwait and offered as a University of Toronto program. It was co-directed by Golnar Rasty and Hala El-Zimaity. Speakers also included: Oyedele Adeyi, Andrew Evans, Naomi Miller, Robert Riddell, Brendan Dickson and John Srigley.

MEETING CALENDAR Canadian Association of Pathologists Conference,

Calgary, AB, July 21-24, 2012. www.cap-acp.org

RESEARCH

GRANTS AWARDED Adeli K. Mechanisms of Hepatic VLDL Overproduction in

Insulin Resistant States. Heart and Stroke Foundation of Ontario Operating Grant. ($299,437) 3 years.

Adeli K. Translational Control of Apolipoprotein B mRNA. NSERC. ($200,000).

Bendeck M. Cadherins and the Regulation of Smooth Muscle Cell Function. Heart & Stroke Foundation of Canada. ($330,258).



Blasutig I. Validation of Five Candidate Pancreatic Cancer Biomarkers. National Cancer Institute’s Early Detection Research Network (USA). ($50,000) 2 years.

Cybulsky M. Reverse Transmigration of Arterial Intimal Dendritic Cells. Heart & Stroke Foundation of Canada. ($289,521). 5 years.

Cybulsky M. Initiation of Atherosclerosis: Mechanisms and Cell Biology. Heart & Stroke Foundation of Canada, Career Investigator Awards. ($83,000).

El-Shawarby M, Khalifa M, Tamimi D, Seth A. Molecular Genetics of Breast Cancer in Eastern province of Saudi Arabia: A Pilot Study. University of Dammam ($422,000) 1 year.

Fish JE. Modulation of Vegf Receptor Activity and Angiogenesis by Slit/Robo Signalling. Heart & Stroke Foundation of Canada. ($275,790).

Fish JE. Regulation of Cardiovascular Disease by MicroRNA. Ontario Ministry of Research & Innovation Early Research Award. ($140,000).

Girardin S. Bacterial Invasion and Mitochondrial Dysfunction. NSERC. ($240,000).

Lee J. Development of Novel Technologies for the Expression of Human and Viral Proteins. University of Toronto Connaught Fund. ($10,000) 1 year.

Lingwood C. Underlying Mechanisms of Regulation of Glycosphingolipid Synthesis in Cells. NSERC. ($170,000).

Ni H. Novel Mechanisms of Platelet Aggregation: Roles of Fibronectin and other Non-Classical Beta3 Integrin Ligands in Thrombosis and Hemostasis. Heart & Stroke Foundation of Canada. ($272,190).

Rand M. The Procoagulant Surface of Activated Platelets: Development and Persistence in Vtiro and in Vivo. Heart & Stroke Foundation of Canada. ($160,544).

Somers G. The Role of the Novel CIC-DUX4 Rearrangement in Pediatric Sarcomagenesis. Hospital for Sick Children, Garron Family Cancer Centre. ($46,907) 1 year.

Templeton D. Cadmium, Cell Signalling and the Cytoskeleton. NSERC. ($130,000).

Wang Q, Prud’homme GJ. GABAergic Signaling as a Potential New Target for Beta-Cell Regeneration. Juvenile Diabetes Research Foundation International. ($500,000US) 2 years.

Waters V, Yau Y, Speert D, Guttman D, Aaron S, Stephenson A, Ratjen F, Tullis E, McKinney M, Lavoie A, Wilcox P, Chilvers M, Freitag A, Stanojevic S, Fisman D, Zlosnik J. The Role of Clonal Pseudomonas Aeruginosa in Cystic Fibrosis Patients in Canada. The Canadian Cystic Fibrosis Foundation Team Grant. ($169,994) 2 years.

Winer DA. Mechanisms of B Lymphocyte Dysregulation in Insulin Resistance. Canadian Diabetes Association – Clinician Scientist Award. ($275,000) 5 years.

Winer DA. B Lymphocyte Dysregulation in the Metabolic Syndrome. Canadian Diabetes Association – Operating Grant. ($275,000) 3 years.

Yang B. Expression and Function of Proteoglycan Versican Regulated my MiroRNA’s. NSERC. ($240,000).

Yang B. The Roles of MicroRNAs in Regulating Cell Activities and Angiogenesis. Heart & Stroke Foundation of Canada, Career Investigator Awards. ($83,000) 5 years.

Yousef GM. miRNA Target Validation Studies. Switch Gear Grant Program. ($3000) 1 year.

Yucel Y, Weinreb R. Sirtuins in Glaucomatous Optic Neuropathy. National Institutes of Health (NIH) (USA). ($84,533) 3 years.

Xu Y, Zhang L. Role of Immune Cell OGRI in Prostate Cancer Development and the Mechanisms Involved. National Institutes of Health ($2,185,805US) 5 years.

CIHR RESULTS Adeli K. Role of Mesenteric Fat and Ceramides in Insulin

Resistance. (CIHR)-China. ($225,000) 2 years.

Beauchemin N. Jothy S, Metrakos PP. CEACAM1 in Colon Cancer Progression and Metastasis. ($834,100) 5 years.

Cybulsky M. Reverse Transmigration of Arterial Intimal Dendritic Cells. ($608,918) 5 years.

Done SJ. Towards a Better Understanding of Breast Cancer Intratumoural Heterogeneity. ($403,829). 3 years.

Fish JE. Modulation of Vegf Receptor Activity and Angiogenesis by Slit/Robo Signalling. ($625,836).

Fish JE. Metabolic Syndrome and Atherosclerosis: Role of microRNAs. CIHR Team Grant. ($1,313,025).

Mahuran DJ. Treating Parkinson's Disease with Drugs that Increase Lysosomal B-Glucocerebrosidase Activity. ($150,000).

Mahuran DJ. Enzyme Enhancement Therapy for GM1 Gangliosidosis. ($821,637).

Ni H. Novel Mechanisms of Platelet Aggregation: Roles of Fibronectin and Other Non-Classical 3 Integrin Ligands in Thrombosis and Hemostasis. ($638,411) 5 years.

Ni H. Pathogenesis of Fetal and Neonatal Alloimmune Thrombocytopenia and Mechanisms of IVIG and Anti-FcRn Therapies. ($557,347) 4 years.

Ohh M. Molecular Characterization of JMML. ($782,020).

Semple JW. Identification of Host Immune Factors Responsible for the Initiation and/or Modulation of Transfusion Related Acute Lung Injury (TRALI). CIHR & Canadian Blood Services. ($749,000) 3 years.

Winer DA. Defining Adaptive Immune Mechanics of Insulin Resistance. ($603,000) 5 years.

Yousef GM. The Role of miRNAs in Renal Cell Carcinoma Pathogenesis and their Clinical Utility as Tumor Markers. ($493,169) 3 years.

Yucel Y. Karrow N, Gupta N. (Co-PI’s). Lymphatics as a Novel Target to Treat Glaucoma. ($579,963) 5 years.

Zhang L, Pintilie M, Tsao MS, Zheng G, Waddell T. Development of Personalized Immunotherapy to Treat Lung Cancer Using Gamma-Delta-T Cells. ($785,005) 5 years.

EDUCATION

RESIDENTS AND FELLOWS SECTION Postgraduate Trainee Research Day LMP would like to congratulate participants of the sixth annual LMP Postgraduate Research Day. Led by the Director of Postgraduate Research, Dr. George Yousef, the day celebrated the achievements of LMP’s residents and post-doctoral fellows.



The theme of the day was “Personalized Medicine: A New Landscape for Laboratory Medicine Practice”. With 32 poster and 6 podium presentations and almost 100 attendees, the event emphasized LMP’s broad scope and solid track record of sustained excellence in research encompassing basic, translational and clinical science.

Key highlights of the day included a presentation by keynote speaker George J. Netto, MD, Director of Surgical Pathology Molecular Diagnostics at Johns Hopkins University, an engaging video about the future of pathology and a new poster presentation format which allowed students to interact directly with a small panel of judges. Students were further engaged in an open discussion with departmental Chair, Dr. Richard Hegele and the Program Director of Anatomical Pathology, Dr. Simon Raphael.

The winners of this year’s Research Day are listed on page 2.

The breadth and depth of the research was impressive. The first place winner of the clinical award, Michael Sidiropoulos, presented on the ability to more accurately distinguish between malignant melanoma and benign moles using fluorescence microscopy. Nicole White, first place winner of the research award, presented on the potential earlier and more accurate diagnosis of kidney cancer by studying dysregulated miRNAs.

The success of LMP’s poster presentations is clearly evident by the number of those accepted at national and international conferences. LMP is confident that presenters at this year’s event will achieve the same success and that their work will provide a strong foundation for future research.

We would like to thank all of the LMP trainees who participated in the event by giving oral and poster presentations. A diverse range of research topics was represented, and without them, the day would certainly not have been possible. We would also like to thank the faculty who served as judges as well as our sponsors, Springer and Ideal Scientific, who contributed generously to our event.

We would also like to thank Paula Nixon for her organizational and logistical support from the initial planning stages to the event itself.

We would like to call for volunteers to participate in next year’s planning committee. Interested individuals should contact [email protected].

Sincerely, The 2012 Postgraduate Research Day Committee including Clarissa Cassol, Lorna Mirham, Ghassan Allo, Ingo Von Both, Ron Francis, Joerg Schwock, Rosalind Silverman, Nicole White, Julie Shaw, Jennifer Shea, Paula Nixon and George Yousef.

New Chief Resident On behalf of Dr. Simon Raphael, the Anatomical Pathology Residency Program would like to congratulate and welcome Dr. Will Chen as the 2012 Chief Resident.

We would like to thank Dr. Michael Sidiropoulos for all of his hard work over the past year and wish him the best in his future endeavors.

New Trainees The Department of Laboratory Medicine & Pathobiology would like to extend a warm welcome to our new trainees starting July 1, 2012:

Anatomical Pathology: Dina Boles, Svetlana Carrigan, Ahmed Shahata, David Kolin, Al-Raheem Peerani and Blerta Starova Neuropathology: Andrew Gao Hematopathology: Larissa Liontos Forensic Pathology: Angela Guenther, Ashwyn Rajagopalan Clinical Chemistry: Joshua Raizman, Tracy Teodoro Medical Microbiology: Danielle Brabant Clinical/Research Fellows: Areej, Alnemer, Jesse Babwah, Gillian Bethune, Michelle Downes, Isabelle Gagne, Hector LiChang, Soledad Martinez, Anapat Sanpavat, Keiyan Sy, Carlos Parra-Herran, Ann Treacy

We would also like to extend our congratulations to our graduating trainees: Residents: Jesse Babwah, Michael, Bonert, Will Dubinski, Hala Faragalla, Angela Guenther, Michael Sidiropoulos, Keiyan Sy Postdoctoral Diploma Trainees: Julie Shaw

Compiled by Paula Nixon

FORENSIC PATHOLOGY The Centre of Forensic Science and Medicine at the University of Toronto has completed a report on its first three years (2008-2011) of supporting academic forensic activities in Toronto. The document is available to view on-line at www.forensics.utoronto.ca

Compiled by Sue Sarju Balaga

GRADUATE STUDENTS SECTION Thesis Defenses - MSc Yasha Amani Andabili (Ben Alman) Possible Role of

Ostteoblasts in Regulating the Initiation of Endochral Repair Process During Fracture Healing.

Bradley Frew (Jeremy Mogridge) Proteolyric Processing of Nlrplb in FIIND Domain is Required for Inflammasome Activity.

Sumaiya Marium (Philip Marsden) Rule of Notch Signalling Network in gene Patterns of Angiogenic EC in 3D matrix and 2D confluent monolayer.

Thesis Defenses - PhD Zina Jeyapalan (Burton Yang) Modulation of micro-RNA

Functions by the 3' Untranslated Regions of CD44 and Tumour Suppressor Candidate 2.

Tania Petruzziello (James Brunton) Molecular Mechanisms of E.Coli Shiga Toxin Pathogenesis.

Ioannis Prassas (Eleftherios Diamandis) Investigating the Anti-Cancer Properties of Cardiac Glycosides.

Dea Shahnias (Dylan Pillai) Targeting Plasmodium Falciparum Heat Shock Pretein 90 (PFHSP90): A Strategy to Reverse Antimalarial Resistance.

Compiled by Rama Ponda & Zamiha Premji



HOSPITAL REPORTS

HOSPITAL FOR SICK CHILDREN Announcement Filling the gaps: New diagnostic tool reflects today’s diverse Canadian paediatric population

When a child undergoes blood tests to diagnose a specific medical condition, obtaining accurate test results is the key to help determine the best treatment options and provide the necessary care. Accurate reference values provide the “normal” result for a healthy child in the general population and until now, these reference values in Canada have had significant demographic gaps, and much of the current data is outdated.

Over the past four years, Dr. Khosrow Adeli, Department of Paediatric Laboratory Medicine at SickKids and Professor, LMP, has led a national project to develop a new, comprehensive database of 40 biochemical markers in an ethnically-diverse Canadian paediatric population, involving nearly 2,200 healthy children and teens. This Laboratory Initiative on Paediatric Reference Intervals (CALIPER) Project is now available to hospitals and paediatricians, and will soon be available to the general public. This new national database is reported in a recent online publication of Clinical Chemistry. Next steps will include testing for an additional 30 biochemical markers, and using transference studies to run tests on different equipment in various hospitals across Canada, to help ensure consistent results, regardless of the patient’s geographic location.

For more information about the CALIPER Project, or to participate, visit www.caliperproject.com

Presentations

Adissu HA, McKerlie C, Fang H, Khokha R, Wood GA. Role of inflammation and metalloproteinase activity in promoting invasive prostate cancer. Canadian Cancer Research Conference. Toronto, November 2011.

Adissu HA, Sunter D, Estabel J, Tuck E, Hooks Y, Carragher D, Clarke K, Newbigging S, Jones N, Morikawa L, White JK, McKerlie C. The utility of complete histopathology analysis in a high-throughput primary phenotyping screen: lessons from the microscope. The Hospital for Sick Children Physiology & Experimental Medicine Research Program Scientific Retreat, Toronto, March 2012.

Bellis M, Ngan B. Cutaneous adnexal tumors in children and adolescents: a 26 year review from a single pediatric hospital. Annual Meeting of the Society of Pediatric Pathology Meeting held in conjunction with USCAP. Vancouver, BC, March 2012.

Taylor G: (co-moderator) Session on perinatal pathology. Annual Meeting of the Society for Pediatric Pathology held in conjunction with USCAP. Vancouver, BC, March 2012.

Wang Y, McKerlie C, Newbigging S, Morikawa L. Perfusion and fixation of mouse. The Hospital for Sick Children Research Institute Retreat. Toronto November 2011.

White JK, Sunter D, Adissu H, Estabel J, Tuck E, Hooks Y, Carragher D, Clarke K, Newbigging S, Jones N, Morikawa L, McKerlie C. Utility of complete histopathological analysis in the high-throughput Sanger Mouse Genetics Project primary phenotyping screen. Wellcome Trust Scientific Conference on Mouse Models of Disease: Linking in vivo observations to pathology endpoints. Hinxton, Cambridge, UK, February 2012.

Invited Lectures

McKerlie C: Interesting phenotypes from the primary screen pathology pilot. EUMODIC 5th AGM. Geneva, Switzerland, November 2011.

McKerlie C: A mouse for every gene: challenges and opportunities in genome-wide functional annotation. University of Manitoba, Faculty of Medicine Edge of Science Signature Lecture Series. Winnipeg, January 2012.

McKerlie C: Mouse line production and phenotyping at the Toronto Centre for Phenogenomics. Institut Clinique de la Souris & Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC). Strasbourg, France, February 2012.

Somers G: Pediatric sarcoma development - lessons learned in the great white north. Royal Children’s Hospital. Melbourne, Victoria, Australia, May 2012.

Somers G: Molecular events in sarcoma development - insights gained while shoveling snow. Peter MacCallum Cancer Institute. Melbourne, Victoria, Australia, May 2012.

MOUNT SINAI HOSPITAL Invited Lectures

Kandel R: Bone and soft tissue pathology - challenges in the diagnosis of bone and soft tissue tumors. USCAP. Vancouver, BC, March 2012.

Kandel R: An update on research topics and future directions in intervertebral disc research. Orthopaedic Research Society Annual Meeting. San Francisco, CA, February 2012.

Kandel R: (Moderator). Intervertebral disc: stem cells & cell line. Orthopaedic Research Society Annual Meeting 2012. San Francisco, CA, February 2012.

Keating S: What’s so special about perinatal pathology? Forensic Pathologists of Ontario. April 2012.

Compiled by Marie Maguire

ST. MICHAEL’S HOSPITAL

Presentations

Abadir A, Streutker C, Brezden-Mazley C, Grin A, Kim Y. Intestinal metaplasia and the risk of gastric cancer in an immigrant Asian Population. Canadian Digestive Diseases Week. Montreal, PQ, February 2012.

Jothy S. Alterations of the renal glomerular podocyte as a cause of clinico-pathological emergencies. Department of Pathology and Molecular Medicine, Queen’s University. Kingston, ON, February 2012.

Karamchandani J. Pericardial glial nodule. Canadian Association of Neuropathologists Annual Meeting. Vancouver, BC, September 2011.



ANATOMIC PATHOLOGY POSITION St. Michael's Hospital is a large and vibrant teaching hospital in the heart of Toronto. The physicians and staff of St. Michael's Hospital provide compassionate care to all who walk through its doors as well as outstanding medical education to future healthcare professionals in more than 20 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care and care of the homeless and vulnerable populations in the inner city are among the Hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing Knowledge Institute, research at St. Michael's Hospital is recognized, respected and put into practice around the world. Founded in 1892, the Hospital is fully affiliated with the University of Toronto.

The Department of Laboratory Medicine at St. Michael’s Hospital invites applications for a full time, faculty position as an Anatomic Pathologist in the Division of Pathology. The successful candidate will receive an academic appointment in the Department of Laboratory Medicine and Pathobiology, University of Toronto, with the appropriate academic rank. The starting date is September 4, 2012, but is flexible.

Applicants must have a M.D. degree and be certified in Anatomic Pathology by the Royal College of Physicians and Surgeons of Canada, or equivalent. Requirements include formal training and experience in general surgical pathology and cytopathology. The position involves diagnostic service, teaching, and development of a collaborative research program in clinical, applied or basic research. The diagnostic service is in the areas of surgical pathology and cytopathology.

The Division of Pathology has 14 pathologists and is affiliated with 4 other divisions in the Department of Laboratory Medicine. A molecular biology laboratory is associated with anatomic pathology, as well as automated immunohistochemistry and electron microscopy services.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, members of sexual minority groups and others who may contribute to the further diversification of ideas.

Please forward a letter of interest, a list of references, including your curriculum vitae to:

Dr. Serge Jothy, Chief, Department of Laboratory Medicine St. Michael’s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8 Tel: (416) 864-5972 Fax: (416) 864-5648 E-Mail: [email protected]

Kovacs K. Endocrine research and its creativity. International symposium to develop practitioners for holistic cancer care. Endocrine organ and stem cell-tissue development and tumorigenesis. Japan, November 2011.

Lazarus A. Role of FcRn and CD44 in the treatment of ITP. Bayer Healthcare. San Francisco, CA, February 2012.

Lazarus A. A new potential therapeutic for experimental ITP. Toronto Platelet Immunobiology Group Seminar. Toronto, January 2012.

Lazarus A. How does IVIg work in autoimmunity and can we replace it with something better? Centre For Blood Research. Vancouver, BC, November 2011.

Lazarus A. Advances in the understanding of the mechanism of action of IVIg. CSL Berhing Sponsored Educational Talk. National Webcast Presentation, October 2011.

Leytin V. Platelet apoptosis mediated by platelet surface receptors. Institute of Clinical Biochemistry and Pathobiochemistry. University of Würzburg. Würzburg, Germany , November 2011.

Leytin V. Apoptosis in the anucleate platelet. Blood Center of Wisconsin and Blood Research Institute. Milwaukee, WI, November 2011. Leytin V. The platelet: apoptosis in bypass of death

receptors. Immunforum, Klinisk

Immunologi & Transfusionsmedicin (KIT). Lund, Sweden, January 2012.

Munoz DG. Recent advances in central nervous system tumors. Arab Health Congress. Dubai, January 2012.

Ni H. Platelets in atherothrombosis: Emerging links between lipoprotein metabolism and platelet function. China-Canada Symposium on Atherosclerosis and Cardiovascular Diseases. Beijing, China, September 2011.

Ni H. Does specificity of anti-platelet antibody dictate the efficacy of ITP therapy? The first affiliated hospital, Anhui Medical University. Hefei, China, September 2011.

Ni H. Thrombosis and thrombocytopenia: lessons from animal models and human patients. University of California. San Diego, CA, October 2011.

Ni H. Integrin ligands in thrombosis and hemostasis: exploring roles of apolipoprotein A-IV and plasma fibronectin. The Scripps Research Institute. La Jolla, CA, December 2011.

Ni H. Does specificity of anti-platelet antibody dictate the efficacy of ITP therapy? 2011 American Society of Hematology Annual Meeting. San Diego, CA, December 2011.

Ni H. Pathogenesis of fetal and neonatal alloimmune thrombocytopenia: lessons from murine models. Immunology Research Group, Institute of Medical Biology, Faculty of Health Sciences. The University of Tromsø. Norway, January 2012.

Ni H. Platelets are versatile cells: new links between lipoprotein metabolism and atherothrombosis. SUNY Downstate Medical Center. New York, February 2012.

Ni H. Platelets are versatile cells: new links between apolipoprotein A-IV and atherothrombosis. Seminars in Lipoprotein Metabolism, Atherosclerosis & Nutrition. Columbia University. New York, February 2012.

Pavenski, K. Transfusion management of a massively bleeding patient. Ontario Transfusion Coordinators Meeting. Toronto, November 2011.

Pavenski K. Management of a massively bleeding patient: facts and arguments from the 2011 MTCC. Transfusion Medicine Symposium. London, ON, November 2011.

Pavenski K. An update in transfusion medicine: transfusion triggers, urgent anticoagulant reversal and deadly reactions. Ross Memorial Hospital Transfusion Medicine Rounds. Lindsay, ON, December 2011.

Prud’homme G.J, Glinka Y, Mohammed N. Role of neuropilin-1 in breast cancer stem cells. 2nd International Conference on Stem Cells and Cancer. Puna, India, October 2011.

Prud'homme GJ, Glinka Y. Neuropilin-1 promotes NF-kappaB signalling and mammosphere formation by human breast cancer stem cells. Canadian Cancer Conference. Toronto, November 2011.



Semple JW, Kim M, Hou J, Lee J, Tabuchi A, Kuebler WM, Chai Z-W, Lazarus AH. Intravenous Gammaglobulin (IVIg) Therapy Prevents Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI) by Directly Inhibiting Recipient Neutrophil Activation in a Murine Model. The American Society of Hematology 53rd Annual Meeting. San Diego CA, December 2011.

Streutker C, Bresden-Mazley C. Her2 Testing in Gastric Carcinoma. Cancer Care Ontario Gastric Cancer Advisory Board. Toronto, December 2011.

Yousef GM. The miRNA regulation of kallikreins: there is a whole new world out there. 4th International Symposium on Kallikreins and Kallikrein-related Peptidases. Rhodes Island, Greece, September 2011.

Yousef GM. The future of kallikreins. 4th International Symposium on Kallikreins and Kallikrein-related Peptidases. Rhodes Island, Greece, September 2011.

Yousef GM. miRNAs: a new paradigm in kidney cancer research. Semmelweis University Medical School. Budapest, Hungary, September 2011.

Yousef GM. Kidney cancer: the new landscape. Updates in Surgical Pathology Conference. Taiba Hospital. Kuwait, January 2012.

Yousef GM. Personalized medicine: rekindling an old flame. Updates in Surgical Pathology Conference. Taiba Hospital. Kuwait, January 2012.

Yousef GM. miRNA in renal cell carcinoma: the journey to clinical applications. 2nd Western New York and Southern Ontario Kidney Cancer Symposium. Buffalo, NY, May 2012.

American Association of Blood Banks Annual Meeting - San Diego, CA, October 22-25, 2011.

Cserti-Gazdewich CM, Pendergrast J, Dharman A, Pavenski K, Krok E, Lin Y, Callum J, Colavecchia C, Reis M. Minor incompatible group O platelet management strategies: alternative practices and outcomes within a multi-center collaborative.

Krok E, Naassan A, Anderson M, Pavenski K. Incidence of passive sensitization and hemolysis following high dose IVIG treatment.

Krok E, Naassan A, Pavenski K. Utilization of massive transfusion protocol in non-trauma patients: a single institution chart review.

Moayedi Y, Venos E, Pavenski K, Trinkaus M. A retrospective chart review of Octaplex administration practices at St. Michael's Hospital.

Ni H. Lessons gained from the mouse models of fetal and neonatal alloimmune thrombocytopenia. 9107-TC recent developments in fetal and neonatal alloimmune thrombocytopenia.

Pavenski K, Naassan A. Massive transfusion protocol in obstetrical patients: a single center retrospective review.

23rd European Congress of Pathology - Helsinki, Finland, August 27- September 1, 2011. Kovacs K. Mixed endocrine and non-endocrine tumors in

the pituitary. Moshkin O, Scheithauer BW, Horvath E, Jentoft M,

Collins PC, Syro LV, Kovacs K. Tumefactive postmenopausal gonadotroph cell hyperplasia.

Scheithauer BW, Horvath E, Abel T, Deal C, Robitaille Y, Osamura R, Kovacs K. Pituitary blastoma: confirmation of an entity.

12th International Pituitary Meeting & 10th International Workshop - Santorini, Greece, October 5-8, 2011. Cusimano M, Rotondo F, Scheithauer BW, Horvath E,

Kovacs K. Aggressive Crookecell adenoma of the pituitary.

Kovacs K. Mixed endocrine-nonendocrine tumors in the pituitary.

Lloyd RV, Scheithauer BW, Horvath E, Kovacs K. Stem cells in the normal pituitary and in pituitary adenomas.

Lombardero M, Quintanar-Stephano A, Horvath E, Kovacs K, Scheithauer BW. Effect of thyroxin on cell morphology and hormone secretion of pituitary grafts in rats.

Moshkin O, Rotondo F, Scheithauer BW, Soares M, Coire C, Smyth HS, Horvath E, Kovacs K. Atypical bronchial carcinoid metastatic to the sella turcica.

Natar AG, Syro LV, Scheithauer BW, Kovacs K, Horvath E, Rotondo F, Cusimano M. Necrotizing infundibuloneurohypophysitis.

Nose V, Ezzat S, Horvath E, Kovacs K, Laws ER, Lloyd RV, Lopes MBS, Asa SL. Protocol for the examination of specimens from patients with primary pituitary tumors.

Rotondo F, Cusimano M, Scheithauer BW, Rotondo A, Syro LV, Kovacs K. Ghrelin the pituitary.

Sav A, Syro LV, Scheithauer BW, Rotondo F, Horvath E, Kovacs K. Silent somatotroph adenoma: a morphologic, immunohistochemical and electron microscopic study: a case report.

Scheithauer BW, Lloyd RV, Abel T, Deal C, Robitaille Y, Osamura RY, Lloyd RV, Kovacs K. Pituitary blastoma: an entity within a tumor syndrome.

Sidiropoulos M, Syro LV, Scheithauer BW, Penagos LC, Uribes H, Ramirez MP, Horvath E, Rotondo F, Kovacs K. Primary melanoma of the sellar region.

Syro LV, Ortiz LD, Scheithauer BW, Uribe H, Penagos LC, Fadul CE, Rotondo F, Horvath E, Kovacs K. Treatment of pituitary neoplasms with temozolomide.

Complied by Dorothy Avery

SUNNYBROOK HEALTH SCIENCES CENTRE &

WOMEN’S COLLEGE HOSPITAL Presentations

Feigenberg T, Covens A, Ismiil N, Ghorab Z, Dube v, Saad RS, Khalifa MA, Nofech Mozes. Is routine appendectomy at the time of primary surgery for mucinous ovarian tumors helpful? SGO 43rd Annual Meeting. Austin, TX, March 2012.

Muise-Helmericks RC, Demcheva M, Zhang A, Bacopulos S, Amemiya Y, Vournakis J, Seth A. Short Poly-N-Acetyl glucosamine (sNAG) Nanofibers regulate gene expression in endothelial cells and keratinocytes. Human Genome Meeting. Sydney, Australia, March 2012.

Pennell N, Cheung M, Alden C, Buckstein R, Ghorab Z, Davidson C, Berinstein NL. First evidence of high incidence of complete and sustained molecular remission and maintenance of immuno responses in patients receiving consolidation with Y90 ibritumomab tiuxetan post R-CHOP for newly diagnosed advanced stage high and intermediate risk follicular lymphoma. ASH Annual Meeting. San Diego, CA, December 2011.

Sade S. Primary cutaneous CD4-positive small/medium pleomorphic T-cell lymphoma. Toronto Dermatological Society Meeting. February 2012.



The Canadian Cancer Research Conference – Toronto, ON, Nov 27-30, 2011. Benatar T, Tang W, Amemiya Y, Evdokimova V, Seth A.

IGFBP7 reduces breast cancer growth by induction of senescence and apoptosis pathways..

Chaterjee S, Badiani K, Seth A, Murphy L, Raouf A. Estrogen signaling suppresses the expression of tumor suppressor gene, IGFBP7.

Chow A, SivanathanL, Amemiya Y, Seth A, Emmenegger U. Molecular profiling of resistance to metronomic cyclophosphamide chemotherapy.

Du WW, Yang BB, Seth A, Yee AJ. Tumor specific expression of Versican/PG-M G3 domain promotes breast cancer cell invasion and bone metastasis.

Evdokimova V, Tognon CE, Benatar T, Sornsen PHB, Seth A. IGFBP7 blocks IGF1 receptor activation by IGF1 while enhancing insulin receptor signaling and sensitivity.

Gordanpour A, Nam RK, Stanimirovic A, Sugar L, Seth A. Higher expression of miR-182 is associated with prostate cancer aggressiveness.

United States and Canadian Academy of Pathology Annual Meeting – Vancouver, BC, March 17-23, 2012. Babwah J, Khalifa MA, Rowsell C. Analysis of addendum

reports in anatomic pathology as a quality improvement initiative.

Chan S, Sherman C, Gabril M, Zbieranowski I, Sugar L, Yousef G, Bjarnason G. Xp11.2 translocations in adult renal cell carcinomas with clear cell and papillary features.

Grin A, Hsieh ET, Brezden-Masley C, Streuker CJ. Gastric biopsies are appropriate for assessment of Her2: a correlation study with resection specimens.

Hsieh E, Henry P, Kwok K, Hanna W. HER2/neu testing in 207 gastric and gastroesophageal junction adenocarcinomas: immunohistochemistry and silver in situ hybridization (SISH) provide effective brightfield methods for clinical HER2 testing.

Kaur H, Eiriksson L, Saad R, Khalifa M, Dubé V, Ghorab Z, Covens A, Barbera L, Ismiil N. Prognostic significance of primary tumour factors in stage III high grade endometrial cancer.

Keith J, Ang LC, Dickson B, Bilbao J, Croul S. Synovial sarcoma of the nervous system: a clinicopathologic study of 9 patients.

Nafisi H, Ghorab Z, Ismiil N, Saad R, Dubé V, Khalifa MA. p16 expression in early müllerian serous carcinogenesis.

Saad RS, El-Sayed A, Shehata A, Mashour M, Hanna W. Immunophenotype profile of breast carcinoma brain metastases in comparison to their breast primaries.

Saad RS, Shehata AF, Silverman JF, Ismiil N, Ghorab Z. Is it possible to differentiate endometrial serous carcinoma from endometrioid type in liquid-based preparation? a cytomorphologic study.

Sidiropoulos M, Hanna W, Raphael S, Jakate K, Ghorab Z. Merkel cell carcinoma immunoreactivity with Pax5.

Wang T, Rowsell C, Hsieh E, J Ramsay, C Streutker. Immunohistochemical profiles of small intestinal adenocarcinomas.

Invited Lectures

Rowsell C: Overview of the CAP cancer checklist for exocrine pancreas. Webex presentation. Cancer Care Ontario and Canadian Association of Pathologists. December 2011.

Compiled by Lesley Nicholson

UNIVERSITY HEALTH NETWORK Announcements Dan Winer received the Castleman Award for the top

paper published in Human Pathology Research for a young pathologist.

Lili Hazrati has won this year's IMS Course Lecturer Award. This award is presented annually for a sustained contribution of three years or more to excellence in lecturing in an IMS graduate course. Dr. Hazrati was nominated by students in the MSC1006H - Introduction to Anatomical Organization of the Brain. The award was presented at IMS Scientific Day held on May 15, 2012.

Presentations

United States and Canadian Academy of Pathology Annual Meeting – Vancouver, BC, March 17-23, 2012. Abi Daoud MS, Nuin P, Chen J, Zhang X, Feilloter H, Tron

VA. microRNAs as prognostic biomarkers in malignant malanoma.

Allo G, Mackay H, Rouzbahman M, Shaw PA, Bernardini M, Clarke BA. ARID1A gene expression in high-grade endometrial carcinomas.

Bellis M, Victor JC, Rouzbahman M, Rasty G. The prognostic significance and outcome of patients with grade 1 stage 1 endometrioid endometrial adenocarcinoma involving the lower uterine segment.

Bilodeau EA, Weinreb I, Dacic S, Muller S, Barker B, Seethala RR. Clear cell odontogenic carcinomas show EWSR1 rearrangements: a novel finding & biologic link to salivary clear cell carcinomas.

Bonert M, Craddock KJ. An in silico approach to finding the expected frequency of coincidental overlaps for in situ hybridization using dual-colour fusion probes.

Cassol CA, Asa SL. Cell cycle regulators in pheochromocytomas (PCTs) and paragangliomas (PGLs) and correlation with SDHx status and FGFR4 genotype.

Chen M, Brandwein J, Craddock KJ, Chang H. Prognostic factors in unfavourable-risk acute myeloid leukemia in the absence of monosomal karyotype.

Conklin CMJ, Craddock KJ, Have C, Tsao MS, Couture C, Ionescu DN. Immunohistochemistry may not be a reliable screening tool for identification of ALK rearrangement (ALKR) in non-small cell lung carcinoma (NSCLC).

Dubinski W, Ghazarian D. Endoglin: an adjunct diagnostic marker to differentiate between benign and atypical vascular lesions/proliferations arising in the breast post-radiation therapy.

George SHL, Milea A, Shaw PA. Proliferation in the normal tubal epithelium is a hallmark of the follicular phase not BRCA1 mutation status.

Goswami RS, Atenafu EG, Waldron L, Xuan Y, Xu W, Reis PP, Kuruvilla J, Good DJ, Bailey DJ, Lai R, Church A, Lam WS, LeBrun DP, Sehn LH, Farinha P, Gascoyne RD, Crump MR, Jurisica I, Kamel-Reid S. Identification of a novel prognostic microRNA signature in mantle cell lymphoma.

Lai J, Magro CM. Acral nevi as possible precursors to acral melanomas?

Li G, Al Daoud N, Evans AJ, Van der Kwast TH. Utility of triple antibody cocktail stain in radical prostatectomy specimens with crushed surgical margins.

Mete O, Erovic B, Irish J, Asa SL. Identification of new target proteins in parathyroid carcinomas.



Milea A, George SHL, Berman H, Gauthier M, Shaw PA. Significance of alterations of the RB1 pathway in high grade serous carcinoma.

Moreno JC, Nair R, Miller NA, BJ Youngson, V Iakovlev, D McCready, SJ Done. DCIS heterogeneity: an integrated RNA-miRNA analysis.

Ofek E, Waddell TK, Keshavjee S, Hwang Dm. Diffuse pulmonary exogenous lipoid pneumonitis – an indicator of inhalational exposure to aerosolized oils?

Rasty G, Kamel-Ried S. Fluorescence in situ hybridization (FISH) for detection of MAML2 rearrangement in patients with adenosquamous carcinoma of uterine cervix.

Saha MN, Jiang J, Chang H. A novel small molecule MIRA-1 induces cytotoxicity in multiple myeloma cells harbouring wild-type or mutant p53.

Saha MN, Koh S, Chang H. Preclinical evaluation of small molecule p53 activating agent prima-1met in waldenstrom macroglobulinemia.

Schaeffer DF, Hafezi-Bakhtiari S, Cino M, Hirschfi GM, El-Zimaity H. Inflammatory bowel disease associated with primary sclerosing cholangitis has different phenotypes: PSC-IBD vs. IBD-PSC.

Shiau CJ, Babwah J, da Cunha Santos G, Boerner SL, Geddie WR, Kamel-Reid S, Wei C,Hwang DM, Tsao MS. Selection of samples for epidermal growth factor receptor (EGFR) mutation analysis in non-squamous non-small cell lung carcinoma.

Siddiqui RF, Baptista AC, Ross C, Good DJ, Sheridan B, Bailey DJ, Craddock KJ. “Double Hit” aggressive B-Cell Neoplasms with B-ALL phenotypes: role of FISH in the diagnosis.

Sidiropoulos M, Hindi Z, Al-Habeeb A, Ghazarian D, Craddock KJ. Fluorescence in situ hybridization (FISH) reliably distinguishes tumour cells of benign melanocytic nevi from those of metastatic melanoma.

Siniavskaia I, Hafezi-Bakhtiari S, Adeyi O. Low proliferation/apoptosis ratio in early biopsies predicts adverse outcome in cardiac death donor liver allografts.

Srigley J, Evans AJ, Yurcan M, Hunter A, Hart J, Mazuryk J, McKnight L, Raby M, Irish J, Chin J, McGowan T, McLeod R, Fleshner N. Improving margin status in radical rrostatectomies through performance measurement and multidisciplinary knowledge transfer (KT) activities: a population level approach to quality improvement.

Torlakovic EE, Young G, Cheung C, Dirnhofer S, Tzankov A. The presence of langerhans cells is positively correlated with the extent of eosinophilia in classical hodgkin lymphoma.

Trudel D, Kron K, Liu L, Trachtenberg J, Fleshner N, Bapat B, Van der Kwast TH Absence of ERG expression predicts early prostate cancer biochemical recurrence when combined with DNA methylation status of a development-associated gene.

Van der Kwast TH, Aldaoud N, Collette L, Sykes J, Bolla M, Bristow RG. Biopsy diagnosis of intraductal carcinoma is prognostic in intermediate and high risk prostate cancer patients treated by radiation.

Vang R, Visvanathan K, Gross A, Maambo E, Gupta M, Kuhn E, Li R, Ronnett BM, Seidman JD, Yemelyanova A, Shih I-M, Shaw PA, Soslow RA, Kurman RJ. Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma.

White NMA, Khella HWZ, Grigull J, Adzovic S, Youssef YM, Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MAS, Evans AJ, Gabril M, Yousef GM. miRNA profiling in metastatic renal cell carcinoma reveals a tumor suppressor effect for miR-215.

Yang Y, Ning Y, Chang H. Identification of micro RNAs within chromosome 1p minimal deletion region associated adverse outcomes in multiple myeloma.

Compiled by Yvonne Bedford

PUBLICATIONS

Adeli K. Closing the gaps in pediatric reference intervals: The CALIPER initiative. Clin Biochem. 2011;44(7);480-2.

Al-Maghraby H, Ghorab Z, Khalbuss W, Wong J, Silverman JF, Saad RS. The diagnostic utility of CK5/6 and p63 in fine-needle aspiration of the breast lesions diagnosed as proliferative fibrocystic lesion. Diagn Cytopathol. 2012;Feb;40(2):141-7.

Babwah J, Khalifa MA, Rowsell C. Analysis of addendum reports in anatomic pathology as a quality improvement initiative. Mod Pathol. 2012;Feb; 25(Supp 2):2063.

Bacopulos S, Amemiya Y, Zubovits J, Burger A, Seth AK. Effects of partner proteins on BCA2 RING ligase activity. BMC Cancer. 2012;Feb; 8;12(1):63.

Baron M, Gomez-Tortosa E, Bochdanovits Z, Gobernado I, Rabano A, Munoz DG, Heutink P, Jimenez-Escrig A. Extended kindred with recessive late-onset alzheimer disease maps to locus. Alzheimer Dis Assoc Disord. 2012;26:91-95.

Beeson CC, Beeson GC, Buff H, Eldridge J, Zhang A, Seth A, Demcheva M, Vournakis JN, Muise-Helmericks RC. Integrin-dependent Akt1 activation regulates PGC-1 expression and fatty acid oxidation. J Vasc Res. 2012;Jan;13;49 (2):89-100.

Bhaduri M, Khalifa M, Tomlinson G, Glanc P. Sonohysterography: the utility of diagnostic criteria sets. AJR Am J Roentgenol. 2012 Jan;198(1):W83-8.

Bredlau A-L, Semple JW, Segel G. Management of immune thrombocytopenic purpura in children: potential role of novel agents. Pediatric Drugs. 2011;13:1-11.

Chan S, Sherman C, Gabril M, Zbieranowski I, Sugar L, Yousef G, Bjarnason G. Xp11.2 translocations in adult renal cell carcinomas with clear cell and papillary features. Mod Pathol. 2012;Feb;25 (Supp 2):814.

Chan SM, Gabril MY, Zbieranowski IJ, Sugar LM, Yousef GM, Bjarnson GA, Sherman CG. Xp11.2 translocations in adult renal cell carcinomas with clear cell and papillary features. Mod Pathol. 2012;25:196A.

Chan SS, Lee L, Chin J, Gomez JA, Moussa M, Yousef GM, Gabril MY. Should fuhrman grading in clear cell renal cell carcinomas be based on nucleoli only? Mod Pathol. 2012;25:195A.

Colantonio DA, Kyriakopoulou L, Chan MK, Daly CH, Brinc D, Venner AA, Pasic MD, Armbruster D and Adeli K. Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 Feb 27.

Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood. 2011;118:6403-6406.



Darlington P, Haugom-Olsen H, von Sivers K, Wahlström J, Runold M, Svjatoha V, Porwit A, Eklund A, Grunewald J. T cell phenotypes in bronchoalveolar lavage fluid, blood and lymph nodes in pulmonary sarcoidosis - indication for an airborne antigen as the triggering factor in sarcoidosis. J Intern Med. 2012 Mar 31.

Du WW, Yang BB, Shan SW,Yang BL, Deng Z, Jeyapalan Z, Lee DY, Shatseva TA, Seth A, Yee AJ. Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy. PLoS One. 2011;6(11):e26396. Epub 2011 Nov 9.

Dubinski W, Gabril M, Iakovlev VV, Scorilas A, Youssef YM, Faragalla H, Kovacs K, Rotondo F, Metias S, Arsanious A, Plotkin A, Girgis AH, Streutker CJ, Yousef GM. Assessment of the prognostic significance of endoglin (CD105) in clear cellrenal cell carcinoma using automated image analysis. Hum Pathol. 2011. [Epub ahead of print]

Dubinski W, Petraki C, Youssef Y, Yousef GM. Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer. Mod Pathol. 2012; 25:159A.

Farr S, Adeli K. Incretin-based therapies for treatment of postprandial dyslipidemia in insulin-resistant states. Curr Opin Lipidol. 2012;Feb;23(1):56-61.

Fendler A, Jung M, Stephan C, Honey RJ, Stewart RJ, Pace KT, Erbersdobler A, Samaan S, Jung K, Yousef GM. miRNAs can predict prostate cancer biochemical relapse and are involved in tumor progression. Int J Oncol. 2011; 39:1183-1192.

Fernandes BF, Weisbrod D, Yücel YH, Follwell M, Krema H, Laperriere N, Herdarian M, Xu W, Payne D, McGowan H, Simpson ER, Saghal A. Neovascular glaucoma after stereotactic radiotherapy for juxtapapillary choroidal melanoma: Histopathologic and dosimetric findings. International Journal of Radiation Oncology Biology Physics. 2011; 80: 377-384.

Ford McIntyre MS, Gao JF, Li XJ, Naeini BM, L. Zhang. Consequences of double negative regulatory T cell and antigen presenting cell interaction on immune response suppression. Int. Immunopharmacol. 2011:11:597–603.

Gao JF, Ford McIntyre MS, Diao J, Juvet SC, Li XJ, Vanama RB, Mak TW, Cattral MS, Zhang L. Regulation of antigen expressing dendritic cells by double negative regulatory T cells. Eur. J. Immunol. 2011;41:2699-2708.

Ghazi AA, Boustani I, Amouzegar A, attarian H, Pourafkari M, Gashti HN, Sabetian T, Tirgari N, Ghazi S, Kovacs K. Postpartum hypercalcemia secondary to a neuroendocrine tumor of pancreas: a case report and review of literature. Iran J Med Sci. 2011;36:217-221.

Gordanpour A, Nam R, Sugar L, Seth AK. MicroRNAs and gene fusions in prostate cancer: from biomarkers to molecularly-based therapeutics. Prostate Cancer and Prostatic Diseases. 2012 Feb 14. doi: 10.1038/pcan. [Epub ahead of print]

Grin A, Hsieh ET, Brezden-Masley C, Streuker CJ. Gastric biopsies are appropriate for assessment of Her2: a correlation study with resection specimens. Mod Pathol. 2012;Feb;25 (Supp 2):667.

Gu P, Fang JG, DSouca C, Kowalczyk A, Chou KY, Zhang L. Trogocytosis of CD80 and CD86 by induced regulatory T cells. Cell Mol. Immunol. 2012 Mar;9(2):136-46. doi: 10.1038/cmi.2011.62. Epub 2012 Feb 6.

Hammond EH, Hanna W, Nofech- Mozes SNM. Neighbourly collaboration to improve breast predictive factors testing in North America. Can J of Path. 2012;4(1):32-37.

Hsieh E, Henry P, Kwok K, Hanna W. HER2/neu testing in 207 gastric and gastroesophageal junction adenocarcinomas: immunohistochemistry and silver in situ hybridization (SISH) provide effective brightfield methods for clinical HER2 testing. Mod Pathol. 2012;Feb;25 (Supp 2):674.

Iakovlev VV, Gabril M, Dubinski W, Scorilas A, Youssef YM, Faragalla H, Kovacs K, Rotondo F, Metias S, Arsanious A, Plotkin A, Girgis AH, Streutker CJ, Yousef GM. Microvascular density as an independent predictor of clinical outcome in renal cell carcinoma: an automated image analysis study. Lab Invest. 2012;92:46-56.

Ilina MV, Kepron CA, Taylor GP, Perrin DG, Kantor PF, Somers GR. Sudden unexpected death due to undiagnosed heart disease in infancy and childhood: a retrospective autopsy study. Pediatrics. 2011;128:e513-e520.

Jakate K, Wong K, Sirbovan J, Hanna W. Cutaneous myoepithelioma arising within hidradenoma of the scalp. J Cutan Pathol. 2012;Feb;39(2):279-85.

Juvet SC, Zhang L. Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions (an invited review). J. Molecular Cell Biology. 2012;4:48-58.

Karamchandani J, Vogel H, Fischbein N, Gibbs I, Edwards MS, Harsh G. Extravascular papillary endothelial hyperplasia mimicking neoplasm following radiosurgery. Neurosurgery. 2011 September [Epub ahead of print]

Kaur H, Eiriksson L, Saad R, Khalifa M, Dubé V, Ghorab Z, Covens A, Barbera L, Ismiil N. Prognostic significance of primary tumour factors in stage III high grade endometrial cancer. Mod Pathol. 2012;Feb;25(Supp 2):1176.

Keith J, Ang LC, Dickson B, Bilbao J, Croul S. Synovial sarcoma of the nervous system: a clinicopathologic study of 9 patients. Mod Pathol. 2012;Feb;25(Supp 2):1798.

Keith J, Bilbao J, Baskin R. JC virus granular neuronopathy and rhombencephalic progressive multifocal leukoencephalopathy: case report and review of the literature. Neuropath.2012 Oct [Epub ahead of print]

Khella HW, White NM, Faragalla H, Gabril M, Boazak M, Dorian D, Khalil B, Antonios H, Bao TT, Pasic MD, Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MA, Yousef GM. Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses. Tumour Biol. 2012;33:131-140.

Khella HWZ, White NMA, Faragalla H, Gabril M, Boazak M, Dorian D, Khalil B, Bao TT, Pasic MD, Honey RJ, Stewart R, Pace KT, Bjarnson GA, Jewett M, Yousef GM. Exploring the role of miRNAs in renal cell carcinoma progression and metastasis through bioinformatic and experimental analyses. Mod Pathol. 2012;25:218A.

Kim M, Johnston MG, Gupta N, Moore S, Yücel YH. A model to measure lymphatic drainage from the eye. Exp Eye Res. 2011; 93:586-91.



Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess C, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC, Vilsen B, Peever J, Ralph MR, Roder JC. Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+- ATPase α3 sodium pump. Proc Natl Acad Sci U S A. 2011;108:18144-18149.

Kollmus H, Post R, Brielmeier M, Fernandez J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedláček R, Habré d´Angelis M, Schughart K. Analysis of structural and functional concepts employed in mouse phenotyping and archiving facilities. Transgenic Res. 2011;Oct;20;(5):1155.

Kuiper JW, Plötz FB, Groeneveld AJ, Haitsma JJ, Jothy S, Vaschetto R, Zhang H, Slutsky AS. High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study. BMC. Anesthesiol. 2011;11:26.

Kushwah R, Oliver J, Duan C, Zhang L, Keshavjee S, Hu J: Induction of immunological tolerance towards adenoviral vectors using a novel dendritic cell based strategy. J. Virology.2012;Jan 18.

Leytin V. Apoptosis in the anucleate platelet. Blood Rev. 2012;26:51-63.

Liang Y, Qiu H, Glinka Y, Lazarus AH, Ni H, Prud’homme GJ, Wang Q. Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb. J Gene Med. 2011;13:470-477.

Lichner Z, Mejia-Guerrero S, Ignacak M, Krizova A, Bao T, Girgis A, Youssef Y, Youssef GM. Pleotrophic action of renal cell carcinoma-dysregulated microRNAs on hypoxia related signalling pathways. Mod Pathol. 2012;25:463A.

Lichner Z, Mejia-Guerrero S, Ignacak M, Krizova A, Bao TT, Girgis AH, Youssef YM, Yousef GM. Pleiotropic action of renal cell carcinoma-dysregulated miRNAs on hypoxia-related signaling Ppthways. Am J Pathol. 2012 [Epub ahead of print]

Ly T, Gupta N, Weinreb RN, Kaufman PL, Yücel YH. Dendrite plasticity of the lateral geniculate nucleus in primate glaucoma. Vision Research. 2011;51:243-50.

Manoranjan B, Syro LV, Scheithauer BW, Ortiz LD, Horvath E, Salehi F, Kovacs K, Cusimano M. Undifferentiated sarcoma of the sellar region. Endocr Pathol. 2011; 22:159-164.

Merims S, Dokouhaki P, Joe B, Zhang L. Human Vδ1 T cells regulate immune responses by targeting autologous immature dendritic cells. Hum Immunol. 2011;72:32-38.

Merims S, Li XJ, Joe B, Dokouhaki P, Han M, Wang ZY, Childs RW, Gupta V, Minden MD, Zhang L. Anti leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T cell adoptive immunotherapy. Leukemia. 2011;25:1415-1422.

Morris S, Parkin P, Science M, Subbarao P, Yau Y, O’Riordan S, Barton M, Allen U, Tran D. A retrospective cross sectional study of risk factors and clinical spectrum of children admitted to hospital with pandemic H1N1 influenza as compared to influenza A. BMJ Open. 2012;2:e000310.

Moshkin O, Syro LV, Scheithauer BW, Ortiz LD, Fadul CE, Uribe H, Gonzalez R, Cusimano M, Horvath E, Rotondo F, Kovacs K. Aggressive silent corticotroph adenoma progressing to pituitary carcinoma. The role of temozolomide therapy. Hormones. 2011;10:162-167.

Nafisi H, Ghorab Z, Ismiil N, Saad R, Dubé V, Khalifa MA. p16 expression in early müllerian serous carcinogenesis. Mod Pathology. 2012;Feb; 25(Supp 2):1215.

Nam RK, Zhang W, Siminovitch K, Shlien A, Kattan MW, Klotz LH, Trachtenberg J, Lu Y, Zhang J, Yu C, Toi A, Loblaw DA, Venkateswaran V, Stanimirovic A, Sugar L, Malkin D, Seth A, Narod SA. New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort. Cancer Biol Ther. 2011;Dec;1;12(11).

Naples M, Baker C, Lino M, Iqbal J, Hussain MM and Adeli K. Ezetimibe ameliorates intestinal chylomicron overproduction and improves glucose tolerance in a diet-induced hamster model of insulin resistance. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 16.

Nassiri F, Cusimano MD, Scheithauer BW, Rotondo F, Fazio A, Yousef GM, Syro LV, Kovacs K, Lloyd RV. Endoglin (CD105): a review of its role in angiogenesis and tumor diagnosis, progression and therapy. Anticancer Res. 2011;31:2283-2290.

Nofech-Mozes S, Ismiil N, Dubé V, Saad RS, Ghorab Z, Grin A, Ackerman I Khalifa MA. Interobserver agreement for endometrial cancer characteristics evaluated on Biopsy material. Obst ans Gyn Int. 2012;Article ID 414086:6.

Nofech-Mozes S, Ismiil N, Dube V, Saad RS, Khalifa MA, Moshkin O, Ghorab Z. Immunohistochemical characterization of primary and recurrent adult granulosa cell tumors. Int J Gynecol Pathol. 2012;Jan;31(1):80-90.

Nofech-Mozes S, Jorden T, Hanna WM, Khalifa MA. Synoptic reporting on breast cancer biomarkers: a novel quality improvement module. Can J Path. 2012;4(4):11-15.

Pavenski K, Freedman J, Semple JW: HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management. Tissue Antigens. 2012;79:237-245.

Petraki C, Dubinski W, Scorilas A, Saleh C, Pasic MD, Komborozos V, Khalil B, Gabril MY, Streutker C, Diamandis EP, Yousef GM. Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectalcancer. Pathol Res Pract. 2012; 208:104-108

Quinn KL, Henriques M, Taubchi A, Han B, Yang H, Cheng ST, Yu H, Luo A, Charbonney E, Tullis E, Lazarus AH, Robinson LA, Ni H, Peterson BR, Kuebler WM, Slutsky AS, Zhang H. Human neutrophil peptides mediate endothelia-monocyte interaction, foam cell formation and platelet activation. Arterioscler Thromb Vasc Biol. 2011;31:2070-2079.

Quintanar-Stephano A, Organista-Esparza A, Chavira-Ramirez R, Kovacs K, Berczi I. Effects of neurointermediate pituitary lobectomy and desmopressin on acute experimental autoimmune encephalomyelitis in lewis rats. Neuroimmunomodulation. 2012;19:148-157.

Raftopoulos SC, Efthymiou M, Streutker CJ, May GR. Education and imaging. Gastrointestinal: Atypical hyperplastic gastric polyposis: a case report and brief review of the literature. J Gastroenterol Hepatol. 2011;26:1693.

Rakovitch E, Nofech-Mozes S, Hanna W, Narod S, Spayne J, Thiruchelvam D, Saskin R, Paszat L. Her2/neu and ki-67 expression predict non-invasive recurrence following breast conserving therapy for ductal carcinoma in situ. Br J Cancer. 2012 Feb 23 [Epub ahead of print]



Rizoli S, Nascimento B Jr, Key N, Tien HC, Muraca S, Pinto R, Khalifa M, Plotkin A, Callum J. Disseminated intravascular coagulopathy in the first 24 hours after trauma: the association between ISTH score and anatomopathologic evidence. J. Trauma. 2011;Nov;71(5 Suppl 1):S441-7.

Rotondo F, Cusimano M, Scheithauer BW, Rotondo A, Syro LV, Kovacs K. Ghrelin immunoexpression in pituitary adenomas. Pituitary. 2011;14:318-322.

Rotondo F, Rotondo A, Scheithauer BW, Cusimano M, Latta E, Syro LV, Kovacs K. Ghrelin immunoexpression in the human hypophysis. Appl Immunohistochem Mol Morphol. 2012;20:77-81.

Ruschoff J, Hanna W, Bilous M, Hofmann M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G. Her2 testing in gastric cancer: a practical approach. Mod Pathol. 2012 Jan [Epub ahead of print]

Saad RS, El-Sayed A, Shehata A, Mashour M, Hanna W. Immunophenotype profile of breast carcinoma brain metastases in comparison to their breast primaries. Mod Pathol. 2012;Feb;25(Supp 2):256.

Saad RS, Ghorab Z, Khalifa MA, Xu M. CDX2 as a marker for intestinal differentiation: its utility and limitations. World J Gastrointest Surg. 2011;Nov;27;3(11):159-66.

Saad RS, Mashhour M, Nofech-Mozes S, Ismiil N, Dube V, Ghorab Z, Faragalla H, Khalifa MA. P16INK4a expression in undifferentiated carcinoma of the uterus does not exclude its endometrial origin. Int J Gynecol Pathol. 2012;Jan;31(1):57-65.

Saad RS, Shehata AF, Silverman JF, Ismiil N, Ghorab Z. Is it possible to differentiate endometrial serous carcinoma from endometrioid type in liquid-based preparation? a cytomorphologic study. Mod Pathol. 2012;Feb;25(Supp 2):1240.

Saleeb R, Faragalla H, Sy K, Yousef GM, Stward R, Streutker CJ. Malignancies arising in allograft kidneys. Mod Pathol. 2012;25:238A.

Salehi F, Scheithauer BW, Kovacs K, Syro LV, Sharma S, Manoranjan B, Cusimano M. O-6-methylguanine-D methyltransferase (MGMT) immunohistochemical expression in pituitary corticotroph adenomas. Neurosurgery. 2012;70:491-496.

Salehi F, Scheithauer BW, Kros JM, Lau Q, Fealey M, Erickson D, Kovacs K, Horvath E, Lloyd RV. MGMT promotermethylation and immunoexpression in aggressive pituitary adenomas and carcinomas. J Neurooncol. 2011;104:647-657.

Sav A, Syro LV, Scheithauer BW, Rotondo F, Builes CA, Horvath E, Kovacs K. Silent somatotroph adenoma: a morphologic immunohistochemical and electron microscopic study: a case report. J Med Cases. 2012;3:43-48.

Semple JW, Kim M, Hou J, Lee YJ, Tabuchi A, Kuebler WM, Lazarus AH. Intravenous gammaglobulin (IVIg) therapy prevents antibody-mediated transfusion related acute lung injury (TRALI) by directly inhibiting recipient neutrophil activation in a murine model. Blood. 2011;118:42.

Semple JW, Gebremeskel S, Aslam R, Ni H, Freedman J. Thymic retention of CD4+CD25hi+FoxP3+ T regulatory (Treg) cells is responsible for peripheral Treg deficiency and platelet and megakaryocyte destruction in active immune thrombocytopenia (ITP). Blood. 2011;118:523.

Semple JW, Kim M, Hou J, McVey M, Lee YJ, Tabuchi A, Kuebler WM, Chai Z-W, Lazarus AH. Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production. PloS ONE. 2011;7:31357.

Sherman C, Jani P, Marks A, Kahn H. D2-40 is expressed on the luminal surface of pulmonary airspaces in normal developing and adult lung but is lost in conditions associated with intra-alveolar infiltrate. Pediatr Dev Pathol. 2011 Dec 9 [Epub ahead of print]

Shi SY, Garcia Martin R, Duncan RE, Choi D, Lu SY, Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K, Wagner KU, Bazinet RP, Woo M. Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. J Biol Chem. 2012 Jan 24.

Sidiropoulos M, Hanna W, Raphael S, Jakate K, Ghorab Z. Merkel cell carcinoma immunoreactivity with Pax5. Mod Pathology. 2012;Feb;25 (Supp 2):548.

Sivapragasam M, Rotondo F, Lloyd RV, Scheithauer BW, Cusimano M, Syro LV, Kovacs K. MicroRNAs in the human pituitary. Endocri Pathol. 2011;22:134-143.

Tabuchi A, Kim M, Semple JW, Kuebler WM. Acute lung injury causes pendelluft between adjacent alveoli in vivo. Am. J. Respir. Crit. Care Med. 2011;183:A2490.

Tam ALC, Gupta N, Zhang Z, Yücel YH. Quantum dots trace lymphatic drainage from the mouse eye. Nanotechnology. 2011;22:425101.

Thon JN, Peters CG, Rowley J, Weyrich AS, Semple JW, Aslam R, Flaumenhaft R, Italiano Jr. JE. The functional role of TLR9 in human platelets. Blood. 2011;118:366.

Tiller H, Killie M, Husebekk A, Skogen B, Ni H, Kjeldsen-Kragh J, Øian P. Platelet antibodies and fetal growth: maternal antibodies against fetal platelet antigen 1a are strongly associated with reduced birthweight in boys. Acta Obstetricia et Gynecologica Scandinavica (AOGS). 2012;91:79-86.

Wang T, Rowsell C, Hsieh E, J Ramsay, C Streutker. Immunohistochemical profiles of small intestinal adenocarcinomas. Mod Pathol. 2012;Feb;25(Supp 2):766.

Waters V, Stanojevic S, Atenafu EG, Lu A, Yau Y, Tullis E, Ratjen F. Effect of pulmonary exacerbations on long-term lung function decline in cystic fibrosis. European Respiratory Journal. 2011 Dec 1 [Epub ahead of print]

White NM, Khella HW, Grigull J, Adzovic S, Youssef YM, Honey RJ, Stewart R, Pace KT, Bjarnason GA, Jewett MA, Evans AJ, Gabril M, Yousef GM. miRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215. Br J Cancer. 2011;105:1741-9.

White NMA, Khella HWZ, Grigull J, Adzovic S, Youssef YM, Honey RJ, Stewart R, Pate KT, Bjarnason GA, Jewett MAS, Evans AJ, Gabril M, Yousef GM. miRNA profiling in metastatic renal cell carcinoma reveals a tumor supressor effect for miR-215. Mod Pathol. 2012;25:251A.

White NMA, Masui O, DeSouza L, Krakovska O, Matta A, Siu KWM, Yousef GM. Relative quantification of protein expression in metastatic clear cell renal cell carcinoma tissue using iTRAQ LC-MS/MS analysis. Mod Pathol. 2012;25:251A.



White NMA, Youssf YM, Jung K, Fendler A, Stephan C, Gabril M, Yousef GM. The microRNA-Kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer. Mod Pathol. 2012;25:468A.

Yousef GM. Personalized Cancer Genomics: The Road Map to Clinical Implementation. Clin Chem. 2012. [Epub ahead of print]

Zeng Q, Zhu L, Tao L, Bao J, Yang M, Simpson EK, Li C, van der Wal DE, Chen P, Spring CM, Wang M, Zhang L, Ruan C, Hou M, Xia R, Ni H. Relative efficacy of steroid therapy in immune thrombocytopenia mediated by anti-platelet GPIIbIIIa versus GPIb antibodies. Am J Hematol. 2012;87:206-208.

Zhang L, Thomson AW. New partners for tolerogenic dendritic cells. Am. J. Transplant. 2011;11:2003-2004.

Zimring JC, Lis Welniak L, Semple JW, Ness PM, Slichter SJ, Spitalnik SL and the NHLBI Alloimmunization Working Group. Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group. Transfusion. 2011;51:435-441.

Books/Book Chapters Cines DB, Kuter DJ, Newland AC, Provan D, Semple JW.

The Handbook: Immune Thrombocytopenia. European School of Haematology. Paris FR. Press 2011.

Horvath E, Kovacs K. Histopathology of Pituitary Tumors. In:Oxford Yextbook of Endocrinology and Diabetes. 2nd Edition. Eds. Wass JAH, Steward PM. Oxford University Press. 2011. pp 121-127.

Kontogeorgos G, Stefaneanu L, Kovacs K, Horvath E. Hypophyis. In: The Human Nervous System. 3rd Edition. Eds. JK Mai, G Paxinos, Elsevier. 2012. pp 584-593.

Semple JW. Mouse models of ITP. In The Handbook: Immune Thrombocytopenia. 1st Edition. Eds. Cines DB, Kuter DJ, Newland AC, Provan D, Semple JW. European School of Haematology. Press 2011. Paris FR. Chapter 1.3. pp 40-54.

LMP Newsletter is a communication of the Department of Laboratory Medicine & Pathobiology, Faculty of Medicine,

University of Toronto. Please send your submission to: Joanne D’Angelo

Laboratory Medicine & Pathobiology 1 King’s College Circle, Rm 6231, Toronto ON M5S 1A5

Tel: 416-978-2557 Fax: 416-9787-7361 E-mail: [email protected]

Next Deadline for Submissions: October 12, 2012



GRADUATE STUDENT RESEARCH DAY March 6, 2012



POSTGRADUATE RESEARCH DAY April 17, 2012



LMP ANNUAL REUNION & BANQUET June 7, 2012



LMP ANNUAL REUNION & BANQUET



ARTS & SCIENCE RECEPTION June 13, 2012

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