World Tuberculosis Day 2014
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Transcript of World Tuberculosis Day 2014
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World Tuberculosis Day 2014The TB situation in 2012: Findings from the joint TB surveillance and monitoring report by ECDC and the WHO Regional Office for Europe
ECDC TB TeamEuropean Centre for Disease Prevention and ControlStockholm, 24 March 2014
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TB notifications by countryIn 2012, 68 423 TB cases were reported in the EU/EEA.The notification rate was 13.5 per 100 000 population(range 3.4–85.2).
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Not included or not reporting
50 to 99 per 100 000
20 to 49 per 100 000
10 to 19 per 100 000
< 10 per 100 000
Figure 1: TB notification rate per 100 000 population by country, EU/EEA, 2012
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EU definition: Confirmed TB cases*
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Figure 2: Percentage of laboratory-confirmed TB cases by country, EU/EEA, 2012
70 to 79%≥ 80%
60 to 69%
< 60%
Not included or not reporting
* Confirmed by culture or by both a positive sputum microscopy result and Mycobacterium tuberculosis nucleic acid identified in nucleic acid amplification test.
Overall, 61.9% (range 21.5–91.4%) of TB cases reported in the EU/EEA were laboratory confirmed.
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TB in children
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Figure 3: TB notification rate in children under 15 years of age per 100 000 child population, by country, EU/EEA, 2012
Not included or not reporting
4 to 9.9 per 100 000 child population
2 to 3.9 per 100 000 child population
≥ 10 per 100 000 child population
< 2 per 100 000 child population
In 2012, 2 845 TB cases in children were reported, accounting for 4.2% of all notified TB cases (range 0–7.8%) in the EU/EEA.
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TB cases of foreign origin
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In 2012, the overall proportion of TB cases of foreign origin in the EU/EEA was 26.8% (range 0.2–85.4%).Figure 4: Percentage of TB cases of foreign origin by country, EU/EEA, 2012
25 to 49.9%
≥ 75%
1 to 24.9%
50 to 74.9%
< 1%
Not included or not reporting
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Extrapulmonary TB cases
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In 2012, the overall proportion of extrapulmonary TB cases in the EU/EEA was 23.0% (range 2.9–48.6%).Figure 5: Percentage of extrapulmonary TB cases by country, EU/EEA, 2012
20 to 29.9%
≥ 40%
10 to 19.9%
30 to 39.9%
< 10%
Not included or not reporting
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Extrapulmonary TB notification over timeExtrapulmonary TB notification rates have remained stable in the last 10 years.
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Figure 6: Extrapulmonary TB notification rate per 100 000 population by year, EU/EEA, 2003−2012
2003 2004 2005 2006 2007 2008 2009 2010 2011 20120
1
2
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Year of reporting
Notifi
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te p
er 1
00 0
00 p
opul
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Multidrug-resistant TB
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In 2012, the overall proportion of TB cases with multi-drug resistance in the EU/EEA was 4.6% (range 0–25.5%).Figure 7: Percentage of multidrug resistance among all confirmed TB cases by country, EU/EEA, 2012
2 to 4.9%
≥ 10%
1 to 1.9%
5 to 9.9%
< 1%
Not included or not reporting
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Multidrug-resistance among new pulmonary TB cases
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Figure 8: Percentage of new pulmonary TB cases with multidrug resistance by country, EU/EEA, 2012
2 to 4.9%
1 to 1.9%
≥ 5%
< 1%
Not included or not reporting
In 2012, the overall percentage of new pulmonary TB cases with multidrug resistance in the EU/EEA was 2.6% (range 0–20.5%).
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Multidrug-resistance among previously treated pulmonary TB cases
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In 2012, the overall proportion of previously treated pulmonary TB cases with multidrug resistance in the EU/EEA was 18.8% (range 0–50.0%).
Figure 9: Percentage of previously treated pulmonary TB cases with multidrug resistance by country, EU/EEA, 2012
10 to 19.9%
≥ 20%
1 to 9.9%
< 1%
Not included or not reporting
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Extensively drug-resistant TB
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In 2012, the proportion of extensively drug-resistant TB cases among multidrug-resistant cases in EU/EEA was 13.7% (range 0–50.0%).
Figure 10: Percentage of extensively drug-resistant TB cases among multidrug-resistant TB cases tested for second-line drug susceptibility, by country, EU/EEA, 2012
10 to 19.9%
1 to 9.9%
≥20%
< 1%
Not included or not reporting
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TB/HIV co-infection
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In 2012, the overall proportion HIV positive among TB cases with known HIV status in EU/EEA was 5.5% (range 0–16.5%).
Figure 11: Percentage of HIV-positive cases among TB cases with known HIV status, by country, EU/EEA, 2012
5 to 9.9%
2 to 4.9%
≥ 10%
< 1%
Not included or not reporting
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Treatment success in new pulmonary TB cases over timeThe treatment success rate in new culture-confirmed pulmonary TB cases notified between 2007 and 2011 has slightly decreased from 79.2% in 2007 to 76.5% in 2011.
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Figure 12: 12-month treatment success rate in new culture-confirmed pulmonary TB cases by year of initial case reporting, EU/EEA, 2007–2011
2007 2008 2009 2010 20110
20
40
60
80
100
79.2 79.4 79.0 77.0 76.5
Year of initial reporting
Trea
tmen
t suc
cess
(%)
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Treatment success in new pulmonary TB casesTreatment success rate for culture-confirmed new pulmonary TB cases notified in 2011 was 76.5% (range: 0–91.3%).
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Figure 13: Treatment success rate in culture-confirmed new pulmonary TB cases notified in 2011, by country, EU/EEA, 2012
* Iceland and Malta reported zero new TB cases in 2011. Three EU/EEA Member States did not report treatment outcome data
EU/EE
AAustr
ia
Belgium
Bulgaria
Cyprus
Czech Rep
ublic
Denmark
Eston
ia
Finlan
d
German
y
HungaryIre
landLat
via
Lithuan
iaMalt
a
Netherl
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NorwayPo
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Portu
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Roman
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Slovak
ia
Sloven
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Sweden
United Kingdom
0
20
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Trea
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Treatment success in previously treated pulmonary TB casesThe treatment success rate for previously treated culture-confirmed pulmonary TB cases notified in 2011 was 55.2% (range 25.0–100.0%).
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Figure 14: Treatment success rate in previously treated culture-confirmed pulmonary TB cases notified in 2011, by country, EU/EEA
* Iceland and Malta reported zero previously treated TB cases in 2011. Three EU/EEA Member States did not report treatment outcome data stratified by treatment history
Subtot
al EU
/EEAAu
stria
Belgi
um
Bulga
riaCy
prus
Czech
Republi
c
Denmark
Eston
iaFin
land
German
y
Hunga
ryIre
land
Latvia
Lithuan
ia
Netherl
ands
Norway
Polan
d
Portug
al
Romani
a
Slova
kia
Slove
nia Spain
Swede
n
United
Kingdo
m0
20
40
60
80
100%
Trea
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t suc
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(%)
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Treatment success rate in confirmed pulmonary TB cases*The treatment success rate for all confirmed pulmonary TB cases notified in 2011 was 72.4% (range 0–90.4%).
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Figure 15: Treatment success rate in laboratory confirmed pulmonary TB cases notified in 2011, by country, EU/EEA, 2012
* Four EU/EEA Member States did not report treatment outcome data
EU/EE
AAustr
ia
Belgium
BulgariaCyp
rus
Czech Rep
ublic
Denmark
Eston
ia
Finlan
d
German
y
HungaryIre
landLat
via
Lithuan
ia
Luxe
mbourg
Malta
Netherl
ands
NorwayPo
land
Portu
gal
Roman
ia
Slovak
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Sloven
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United Kin...
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20
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Trea
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t suc
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Treatment success rate in extrapulmonary TB*The treatment success rate in extrapulmonary TB cases notified in 2011 was 82.2% (range 59.0–100%).
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Figure 16: Treatment success rate in extrapulmonary TB cases notified in 2011, by country, EU/EEA, 2012
* Five Member States did not report stratified treatment outcome data
EU/EE
AAustr
ia
Belgium
BulgariaCyp
rus
Czech Rep
ublic
Denmark
Eston
ia
German
y
Hungary
Icelan
dIre
landLat
via
Lithuan
iaMalt
a
Netherl
ands
Norway
Polan
d
Portu
gal
Roman
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Slovak
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Sloven
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Sweden
United Kin...
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(%)
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Treatment success rate in multidrug-resistant TB*The treatment success rate for all multidrug-resistant TB cases notified in 2010 was 33.6% (range 0–100.0%).
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Figure 17: 24-month treatment success rate in multidrug-resistant TB cases notified in 2010, by country, EU/EEA, 2012
* Slovenia reported zero MDR TB cases in 2010, 9 Member States did not report treatment outcome data for MDR TB cases
EU/EE
AAust
ria
Belgium
Bulgari
a
Czech R
epub
lic
Denmark
Eston
ia
German
y
Hunga
ryIre
land
Latvi
a
Lithu
ania
Malta
Netherl
ands
Norway
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Portu
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Roman
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Slova
kia
Swed
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United
King
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Treatment outcome in multidrug-resistant TB over timeTreatment outcomes for multidrug-resistant TB cases improved slightly between the 2008 and 2010 cohort, EU/EEA.
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Figure 18: 24-month treatment outcome in multidrug-resistant TB cases notified from 2008 to 2010, by year of initial case reporting, EU/EEA, 2012
Success Died Failed Defaulted Still on treatment
Transferred or unknown
0
10
20
30
40
cohort 2008cohort 2009 cohort 2010
Trea
tmen
t suc
cess
(%
)
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Treatment success in extensively drug-resistant TB*The treatment success rate in extensively drug-resistant TB cases notified in 2009 was 25.0% (range 0–66.7%).
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Figure 19: 36-month treatment success rate in extensively drug-resistant TB cases notified in 2009, by country, EU/EEA, 2012
* Cyprus, Denmark, Iceland, Malta, Slovakia, Slovenia and Sweden reported zero XDR TB cases in 2009, 12 countries did not report SLD DST results or stratified treatment outcome data
EU/EEA Austria Belgium Bulgaria Czech Republic
Estonia Latvia Lithuania Norway Poland Romania United Kingdom
0
20
40
60
80
Trea
tmen
t suc
cess
(%
)