Workshop in PhnomPenh regarding As and Hg determination 12-14 Dec 2012

Lars Lundmark Analytical Chemistry, Department of Chemistry, Umeå University, S-901 87 Umeå, Sweden

Background

ISP ,Uppsala University Sweden Support Network between Bangladesh ,Lao and Cambodia Universities in research cooperation and exchanging of knowledge

MonitoringArsenic contamination of groundwater has been known forLong time in in Bangladesh and now some part of Cambodiaand Lao PDR face same problem and thus testing of As andHg is very important task to avoid health effect for people using this water

Lars Lundmark Umea University has been involved longtime in Mekong region (MRCS)setting up Water Quality laboratories in Thailand ,Vietnam, Lao PDR and Cambodia. In Umea University we now focus on speciation . “Determination of exact chemical form or compound in which an element occurs in a sample. For example determination of whether arsenic occurs in form of trivalent or pentavalent ions or as part of an organic molecule.

Monitoring

We need powerful analytical techniques that can provide highly selective, sensitive, rapid, and precise measurements

HPLC

SFC

Separation

GC

Detection

MS

ICP-MS

AAS

MIP-AES

GC-ICP-MS at Umea University Sweden

Determination of Mercury in Fish (11.5 kg)

Organic Mercury compound and in particular methyl mercury are nowdays treated as a potent neurotoxin (lethal oral dose is 0.2g) The serve toxic actions of methylmercury was recognized during the Mianamata incident in Japan .There it was observed that woman with symptoms of mild methylmercury poisoning gave birth to children with severe neurological damages that was overall analogoues to cerebral palacyusCadmium is another very toxic compound which stays in kidney and accumulates for every year od lifetime .This metal can be analyzed by ICP,ICP-MS or GFAAS (Graphite furnece Atomic Absorbance spectroskopy

Sampling for Cadmium in Moose kidney

http://www.bipm.org/utils/common/pdf/final_reports/QM/P43/CCQM-P43.pdf

Or in white hare (Type of wild rabbit)

AAS lab in Saigon National University Vietnam

Mercury analyser using old Perkin Elmer AAS and Amalgalmation trap

Hydride AAS system in Lao PDR

The Hydride system setup in RUPP ,CAmbodia

Determination of PhTs in BCR (CRM-477) by MI-SSID

TPhT• No difference between the results obtained before and after correction for degradation.• Dephenylation of TPhT does not give rise to errors if the incipient and spiked species are degradated to the same degree.

DPhT• Uncorrected DPhT values agree well with values reported by others.• Values corrected for dephenylation of TPhT are 50% lower than the indicative value. The reported indicative value for DPhT is likely to be too high.

MPhTNo significant difference between uncorrected and corrected values for MPhT because of the low concentration of DPhT compared to MPhT and low dephenylation of TPhT and DPhT (<10%)

Conclusion …..

Future aspects

Study of the metabolism of butyltin compunds in bilological systems.

Oral administration of MI-spike of organotins in laboratory animals (Sanz-Medel et.al. Anal.Chem. 2005,77,7724)

Widen/enhance the application of the MI-spike in other fields

Geochemical modelling, calculation of transformation adsorbtion, desorbtion and transformation rates in soils/sediments

Slut

Tack!

a) Ratio 120/124 for TPhT

MPhTs

ssmTBT

MPhTspmTPhTMPhTspMPhTsp

DPhTs

ssmTPhT

DPhTspmTBTDPhTspDPhTsp

ssmTPhT

TPhTspmTPhTTPhTspTPhTsp

TPhTs

NFAtAtRAtRAt

NF

NFAtAtRAtRAt

NFAtAtRAtRAt

NN

10120124124/120,

124,

124/120,

120,

10

7120124124/120,

124,

124/120,

120,

7120124124/120,

124,

124/120,

120,

b) Ratio 120/122 for TPhT

MPhTs

ssmTBT

MPhTspmTPhTMPhTspMPhTsp

DPhTs

ssmTPhT

DPhTspmTBTDPhTspDPhTsp

ssmTPhT

TPhTspmTPhTTPhTspTPhTsp

TPhTs

NFAtAtRAtRAt

NF

NFAtAtRAtRAt

NFAtAtRAtRAt

NN

10120122122/120,

122,

122/120,

120,

10

7120122122/120,

122,

122/120,

120,

7120122122/120,

122,

122/120,

120,

c) Ratio 120/118 for TPhT

MPhTs

ssmTBT

MPhTspmTPhTMPhTspMPhTsp

DPhTs

ssmTPhT

DPhTspmTBTDPhTspDPhTsp

ssmTPhT

TPhTspmTPhTTPhTspTPhTsp

TPhTs

NFAtAtRAtRAt

NF

NFAtAtRAtRAt

NFAtAtRAtRAt

NN

10120118118/120,

118,

118/120,

120,

10

7120118118/120,

118,

118/120,

120,

7120118118/120,

118,

118/120,

120,