Wildtype versus Mutant Ms. Alvarez [email protected] Arora Lab University of California Irvine...
-
date post
22-Dec-2015 -
Category
Documents
-
view
217 -
download
0
Transcript of Wildtype versus Mutant Ms. Alvarez [email protected] Arora Lab University of California Irvine...
Wildtype versus Mutant
Ms. Alvarez
Arora Lab
University of California Irvine
Developmental and Cell Biology
Department
UC Irvine
QuickTime™ and a decompressor
are needed to see this picture.QuickTime™ and a
decompressorare needed to see this picture.
Dr. Kavita AroraDr. Kavita Arora
Associate Professor
J. ChoJ. Cho
PhD StudentPhD Student
M. AlvarezM. Alvarez
PhD StudentPhD Student
What is the difference between these individuals?
• Wolverine is a mutant and Ms. Alvarez is wild-type• Wild-type is the typical form• Mutants are organisms who’s DNA has been
altered. These organisms display new characteristics or traits not found in wild-type.
Why do scientist make mutant organisms?
• The image “http://nfs.unipv.it/nfs/minf/dispense/immunology/nunu_mouse2.jpg” cannot be displayed, because it contains errors.
• To study the function/ role of the gene that has been mutated.
Drosophila Melanogaster, a popular genetic model organism
• ~ 50% of fly genes have vertebrate homologs
• Small and easy to grow in lab
• Short generation time • Produce high
amounts of offspring
QuickTime™ and a decompressor
are needed to see this picture.
Drosophila Melanogaster is used to study the biological processes
underlying: • Embryonic
development
• Neurodegenerative disorders
• Diabetes
• Aging
• Drug abuse
• Cancer
QuickTime™ and a decompressor
are needed to see this picture.
Project goal: Identify the function of Myostatin in
Drosophila Myostatin fly mutants die at pupa stage