Which Reviewing Editor?

Subject area

Neuroscience Markus Amann, Jason Carter, Yumei Feng, Brian Gulbransen, Fiona McBryde

Cardiovascular control Jason Carter, James Clark, Ellen Dawson, Yumei Feng, Louise Naylor, Nina Stachenfeld

GI and epithelial Brian Gulbransen

Heart/cardiac muscle Mary Diaz, Andrea Fellet, Glen Foster, Matthew Kay, Fadi Salloum, Song Yao

Environmental and exercise Jill Barnes, Tracy Baynard, Joseph Costello, Richard Ferguson, James Fisher, Louise Naylor, Jaume Padilla, Gary Pierce, Peter Rasmussen, R. Scott Rector, Raymond Reynolds, Harry Rossiter, Dick Thijssen, Lauro Vianna

Muscle Martin Behrens, Nathaniel Szewczyk, Takashi Yamada

Endocrinology Richard Wainford, Matthew Whim

Renal Matthew Bailey, Havovi Chichger, Connie Ow, Reetu Singh

Respiratory Silvia Conde, Federico Formenti, Glen Foster, Caroline Jolley, Davi Jose de Almeida Moraes, Leah Reznokiv, Haiyang Tang, Kai Yang

Vascular Ellen Dawson, David Edwards, Richard Ferguson, Louise Naylor, Gary Pierce, Can Ozan Tan, Haiyang Tang, Qiujun Yu

Reviewing Editor(s)

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Amann, Markus University of Utah USA

Neuroscience Altitude Exercise Fatigue Muscle

The impact of cardiovascular diseases on group III/IV-mediated feedback and associated receptors and to what extent these alterations contribute to the circulatory abnormalities and premature fatigue characterizing patients with heart failure or hypertension.

- Arterial / Venous catheterization - Electrical nerve stimulation - Exercise - Muscle biopsies - Nerve block - Transcranial magnetic stimulation

Bailey, Matthew The University of Edinburgh, UK

Renal Hypertension Electrolyte balance Epithelial transport Renal vasculature Renin-angiotensin system

The causes and consequences of salt-sensitive hypertension. Examining the role of the renal tubule and renal vasculature originating/sustaining hypertension. Defining the interplay between multiple systems (e.g. CNS/kidney/vasculature) in the control of sodium balance and blood pressure.

- Rodent transgenic models of human disease - In vivo renal and cardiovascular physiology - Gene/protein expression - human physiology

Barnes, Jill University of Wisconsin-Madison, USA

Environmental and exercise Arterial Blood flow Cerebral Exercise Muscle Nerve

Human exercise physiology. How lifestyle modifications prevent, and chronic disease accelerates the effects of ageing on neurovascular control of the circulation, arterial stiffness, and cerebral blood flow regulation.

- Ultrasound - Transcranial Doppler - Microneurography - Arterial stiffness - Flow-mediated dilation - Systemic haemodynamic measurements - Blood sample analysis - Exercise testing - Neuroimaging

Baynard, Tracy University of Illinois at Chicago, USA

Environmental and exercise Exercise intolerance Exercise prescription Obesity Diabetes Down syndrome Physiologic markers

Interactions between cardiovascular function and exercise in special populations (e.g. obesity, diabetes, multiple sclerosis, intellectual disability, heart failure). Employing both acute and chronic exercise models to study the effects either aerobic and/or resistance exercise has on CV function in humans.

- Applied exercise testing and training - Autonomic function (e.g. heart rate variability,

blood pressure variability) - Arterial function (e.g. central BP, stiffness, limb

blood flow, FMD) - Heart function (e.g. ultrasound)

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Behrens, Martin University of Rostock, Germany

Muscle Neuromuscular function Fatigue Exercise training

Mechanisms of fatigue and their role in human performance in health and disease. Acute and chronic adaptation of the neuromuscular system, and musculoskeletal rehabilitation.

- Dynamometry - Electromyography - Electrical nerve stimulation - Transcranial magnetic stimulation - Near-infrared spectroscopy

Carter, Jason Michigan Technological University, USA

Neuroscience Cardiovascular control Blood pressure Exercise Sympathetic nervous system

Neural control of circulation in humans, sympathoneural reactivity to mental stress, sleep and autonomic control in humans and sex differences in sympathetic neural activity.

- Microneurography - Blood pressure - Sleep - Baroreflex - Cardiovascular reactivity

Chichger, Havovi Anglia Ruskin University, UK

Renal Epithelial transport Cardiovascular Vascular complications Glucose GPCR signalling

Understanding the molecular mechanisms which regulate junctions at the endothelial and epithelial barriers in disease states linked to metabolic disease, trauma and infection.

- Primary cell culture models - Western blot - Immunohistochemical assays - Confocal microscopy - In vitro cell studies - Measuring transepithelial and endothelial

resistance - Angiogenesis measurements

Clark, James Kings College London, UK

Cardiovascular control Cardiac remodelling Myocardial infarction Stress Kinase signalling

Myocardial responses to stress. Particular interest in kinase signalling in the heart as a controller for cardiac remodelling following pressure overload and myocardial infarction.

- In vivo experiments in rodents - Models of cardiac injury and trophy including

myocardial infarction, aortic banding and transplantation

- Implantation of telemetry and other devices and invasive and non-invasive rodent cardiac haemodynamics (PV catheter, Doppler and Ultrasound)

- Non-invasive imaging including PEt/CT, SPECT/CT and MRI

- Molecular and biochemical laboratory techniques for determination of protein kinase activation and activity

- Immunohistochemistry - Confocal microscopy

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Conde, Silvia University of Lisbon, Portugal

Respiratory Physiology/metabolism Ventilation Glucose

The carotid body, a peripheral chemoreceptor whose main stimulus is hypoxia. Recently discovered that the carotid body also senses hyperinsulinemia, and showed that carotid body overactivation is present in hypercaloric animal models of insulin resistance and hypertension. Dedicated to understanding the link between the carotid body and dysmetabolism, and to find new targets to treat metabolic diseases.

- In vivo and ex vivo electrophysiology - Ventilatory recordings - Pletysmography - Metabolic evaluation - In vivo cardio respiratory evaluation

Costello, Joseph University of Portsmouth, UK

Environmental and exercise Exercise Temperature Human performance

Understanding the physiological effects of various stressors (e.g. exercise, temperature, clothing) on human performance. Establishing evidence-based practice in sport and exercise science through the publication of high quality systematic reviews and meta-analyses.

- Blood testing - Infrared thermography

Dawson, Ellen Liverpool John Moores University, UK

Cardiovascular control Vascular Vascular Arterial Blood flow Exercise Cardiovascular Endothelial function Physical activity Cardiovascular control

The impact of acute exercise on cardiovascular function. The role of physical activity on cardiovascular function and health. The role of the endothelium in regulating vascular function.

- Vascular ultrasound - Flow-mediated dilation - Intima-medial thickness - Blood flow - Non-invasive assessment of cardiovascular

structure and function

Diaz, Mary University of Edinburgh, UK

Heart/cardiac muscle Heart EC coupling Cardiac muscle contraction Cardiac myocyte function regulation Ion channels

EC-coupling, cellular processes that regulate cardiac function in health and disease, animal models of cardiac disease, the role of physical exercise on cardiac performance and iron-overload impact on cardiac myocytes’ function.

- Wide-field fluorescence and confocal microscopy - Electrophysiology - Small animal surgery - Histology - Rodent histopathology - Immunostaining - Molecular biology

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Edwards, David University of Delaware, USA

Vascular Endothelial function Arterial stiffness Blood pressure Exercise

Vascular function/dysfunction in healthy and diseased states. Cardiovascular responses to exercise and other acute and chronic interventions.

- Exercise testing - Blood testing

Fellet, Andrea University of Buenos Aires, Argentina

Heart/cardiac muscle Heart Hormones Nitric oxide Thyroid

Thyroid hormones, heart function, age, gender, nitric oxide and mitochondrial function.

- Immunohistochemical assays - ELISA - RIA - Western blot - Real time RT-PCR

Feng, Yumei University of Nevada, USA

Cardiovascular control Neuroscience Renin-angiotensin system Blood pressure regulation Central nervous system Brain Hypertension Metabolism Diabetes

The neural mechanisms of hypertension, obesity and diabetes, with special focus on the brain renin-angiotensin system.

- Telemetry blood pressure and heart rate recording

- Brain nuclei micro-injection and delivery of therapeutics

- In vivo models of hypertension, obesity and diabetes in mice

- Renin-angiotensin signalling transduction

Ferguson, Richard University of Loughborough, UK

Vascular Environmental and exercise Muscle Exercise Human performance Vascular function Vascular adaptation

Human exercise physiology, skeletal muscle and peripheral vascular adaptations to exercise and exercise training, and novel training interventions for performance and health.

- Exercise - Muscle biopsies - Flow-mediated dilation - Venous occlusion plethysmography - Standard cellular/molecular techniques and

assays: RT-PCR and Western blot - Immunohistochemistry

Fisher, James University of Birmingham, UK

Environmental and exercise Autonomic Blood Nervous system

Neural cardiovascular control during exercise, autonomic dysfunction in chronic disease and cerebrovascular regulation during exercise.

- Sympathetic microneurography - Heart rate variability - ECG - Blood pressure - Exercise testing

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Formenti, Federico University of Oxford, UK

Respiratory Integrative Control of breathing

Integrative human physiology, physiological responses to hypoxia and biomechanics and energetics.

- In vivo physiological monitoring - Cardiorespiratory exercise testing - Intra-arterial oxygen sensing

Foster, Glen University of British Columbia, Canada

Heart/cardiac muscle Respiratory Altitude Sleep apnoea Cardiorespiratory control Vascular function Autonomic control Hypoxia Hypercapnia Human and integrative physiology

Influences of intermittent hypoxia and sleep apnoea on cardiorespiratory function. Integrated cardiovascular reflexes and coronary blood flow regulation. Pulmonary vascular control and hypoxic adaptation.

- Blood gas control and manipulation - Contrast echocardiography - Doppler ultrasound (vascular/cardiac/transcranial) - Vascular reactivity - Blood flow - Chemoreflex - Baroreflex - Metaboreflex - Microneurography - Blood pressure monitoring - Polysomnography

Gulbransen, Brian Michigan State University,USA

GI and epithelial Neuroscience Enteric Glia Inflammation Nervous system

Enteric neuroinflammation, intercellular communication and glial physiology.

- Live cell imaging - Immunohistochemistry - Genetic animal models - Animal models of inflammation - Ex vivo and in vivo assays of GI physiology

(motility and secretion) - Electrophysiology

Jolley, Caroline King’s College, UK

Respiratory Dyspnea Neural respiratory drive Chronic obstructive pulmonary disease Pulmonary rehabilitation

Respiratory muscle function and physiology in health and disease.

- Surface mechanomyography - Electromyography

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Kay, Matthew The George Washington University, USA

Heart/cardiac muscle Arrhythmias Cardiac Electrophysiology Fluorescence Imaging Metabolism Physiology

Mechanisms of arrhythmias. The interplay between cardiac work, hypoxia, and ischemia and their impact on electrical activity and mitochondrial function. The role of altered autonomic tone in heart failure and optical approaches to study cardiac autonomic tone in health and disease.

- Organ level electrophysiology and pressure development

- High speed fluorescence imaging of fluorescent probes (optical mapping) and NADH

- Optogenetics - Myocardial absorbance spectroscopy - Excised perfused hearts - Animal models of heart failure (TAC) - Signal and image processing

McBryde, Fiona University of Auckland, New Zealand

Neuroscience Activity Autonomic Blood pressure Cardiovascular Hypertension Nervous system Neurophysiology Sympathetic

Neural control of arterial pressure in health and disease. Investigating the role of the cardiovascular system in mitigating the damage of ischemic stroke, and interactions between cerebrovascular regulation and blood pressure control.

- Long-term monitoring of cardiovascular signals by telemetry

- Blood pressure - Sympathetic nerve activity - Tissue oxygen - Intracranial pressure - Blood flow - Cardiovascular disease - Hypertension - Heart failure - Stroke - Chemoreceptor and baroreceptor testing and

functions José de Almeida Moraes, Davi University of Sao Paulo, Brazil

Respiratory Control of breathing Neuronal networks Chemoreception Motoneurons, Electrophysiology Ion channels

Central generation of respiratory rhythm and pattern at molecular, biophysical, synaptic and neuronal network levels. Investigating cellular and molecular mechanisms of sensory control of breathing.

- In vivo assessment of respiratory function - Nerve and EMG recordings - Patch clamp in situ and in vitro - Confocal Microscopy - Calcium imaging - Protein and gene expression - Chemogenetic and optogenetic strategies in vivo,

in situ and in vitro

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Naylor, Louise The University of Western Australia, Australia

Environmental and exercise Cardiovascular control Vascular Exercise Vascular endothelium Heart

Human exercise physiology, cardiovascular adaptations to exercise training for cardiovascular and metabolic disease. Special focus on vascular endothelium and cardiac morphological and functional adaptations.

- Vascular function: Flow mediated dilation, intima-medial thickness (IMT) and pulse wave velocity (PWV)

- Cardiac imaging: Echocardiography, Cardiac MRI, - Clinical exercise physiology techniques: stress

testing, cardiorespiratory function, body composition, blood pressure (AMBP)

Ow, Connie National Cerebral and Cardiovascular Center, Japan

Renal Diabetes Hypoxia Ischaemia Kidney Nephropathy Reperfusion

Acute kidney injury, cisplatin-induced nephropathy, ischaemia-reperfusion injury, contrast-induced nephropathy, chronic kidney disease, diabetic nephropathy, polycystic kidney disease, renal hypoxia and chronic hypoxia.

- Oxygen telemetry - Assessment of glomerular filtration rate using NIC-

Kidney devices - Renal angiography - Oxygen electrodes

Padilla, Jaume University of Missouri, USA

Environmental and exercise Vascular function, Blood flow Physical activity Insulin resistance Obesity Diabetes, Adipose tissue

Understanding the physiological and molecular mechanisms by which physical inactivity and obesity-associated insulin resistance leads to impaired vascular function.

- Non-invasive assessment of vascular function and stiffness in humans and animals

- Ex vivo measures of vasomotor function in isolated arteries

- Cell culture - Standard cellular/molecular techniques and

assays.

Pierce, Gary The University of Iowa, USA

Vascular Environmental and exercise Blood flow Inflammation Endothelial

Mechanisms that contribute to vascular dysfunction in humans in ageing, obesity, prediabetes, hypertension, COPD, anxiety and preeclampsia. Acute experimental and short-term interventions testing the efficacy of pharmacological and lifestyle (e.g. exercise training, weight loss, dietary) interventions on vascular, autonomic and cognitive function in humans.

- Pulse wave velocity - Central blood pressure haemodynamics - Carotid artery stiffness via ultrasound - Brachial artery flow-mediated dilation - Venous occlusion plethysmography - 24 hour ambulatory blood pressure monitoring - Maximal exercise testing and exercise training - Endothelial cell culture

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Rasmussen, Peter University of Copenhagen, Denmark

Environmental and exercise Brain Central nervous system Blood flow

Blood flow, oxygen transport and energy metabolism in the human brain, particular during exercise or hypoxia, or both.

- Transcranial Doppler ultrasound - Systemic haemodynamic measurements - Cycle ergometry exercise testing - Jugular venous blood sampling - EEG - MRI - PET

Rector, R. Scott University of Missouri, USA

Environmental and exercise Diabetes Insulin resistance Fatty Liver Disease Metabolism Physical Activity

The role of hepatic mitochondria in the development and progression of non-alcoholic fatty liver disease. Determining underlying mechanisms and therapeutic targets non-alcoholic fatty liver disease. The role of exercise in the regulation of hepatic mitochondrial content and function.

- Animal models of non-alcoholic fatty liver disease - Western blotting - Spectrophotometry - Real-time polymerase chain reaction - Blood testing

Reynolds, Raymond University of Birmingham, UK

Environmental and exercise Motor control Balance Tremor Vestibular function

Sensorimotor control of balance, mechanisms of tremor and vestibular reflexes.

- Vestibular stimulation - Motion capture and force plate analysis - Time-frequency analysis of tremor - System identification techniques

Reznikov, Leah University of Florida, USA

Respiratory Cystic fibrosis Asthma Epithelial cells Mucus Animal models Airway hyperresponsiveness Neural control of airway physiology

Paediatric airway diseases. The role of the nervous system in airway disease. Neuroplasticity, mucus secretion and epithelial cell biology.

- flexiVent, - Ussing chamber - Transcriptomics - Lung slices - Live imaging - Primary culture (airway cells, neurons). - Ovalbumin sensitization - Large animal models

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Rossiter, Harry University of California, Los Angeles, USA

Environmental and exercise Exercise Magnetic nuclear resonance

Integrative exercise physiology, oxidative metabolism, exercise intolerance, fatigue, control of oxidative phosphorylation, mitochondrial function and clinical and translational research in health, ageing, cardiovascular and pulmonary disease.

- Cardiopulmonary exercise testing - Pulmonary function - Skeletal muscle magnetic resonance spectroscopy

and imaging - Near-infrared spectroscopy - Doppler ultrasound - Isokinetic dynamometry - High resolution tissue respirometry

Salloum, Fadi Virginia Commonwealth University, USA

Heart/cardiac muscle Ischemia/reperfusion Ischemic heart failure Cardioprotective signalling Cardiac contractility

Identification of novel targets for pharmacologic or gene therapy following myocardial infarction and ischemia-related injury, including NLRP3 inflammasome, mitochondrial dysfunction and detrimental abnormal expression of certain structural proteins in the heart leading to reduced contractility and failure. The role of hydrogen sulfide donors and relaxin receptor agonists in ameliorating the progression of ischemic heart failure with emphasis on microRNAs.

- In vivo models of myocardial infarction in mice, rats and rabbits, including CAESAR conscious rabbit model of infarction

- Cardiac function assessment using echocardiography (including rabbits)

- Molecular studies involving microRNAs and proteins as well as adult cardiomyocyte preparation for simulated ischemia/reoxygenation studies in vitro

Singh, Reetu Monash University, Australia

Renal Cardiovascular Denervation Disease Hypertension

Solitary kidney, hypertension, renal disease, renal denervation and kidney development.

- Surgical (large animal) - Blood pressure monitoring - Renal function monitoring - Radiofrequency catheter-based renal denervation - Molecular biology

Smith, Scott University of Texas, USA

Environmental and exercise Sympathetic nerve activity Muscle reflexes Blood pressure Hypertension Heart failure

Neural cardiovascular control during exercise. Autonomic dysfunction in cardiovascular disease with a focus on the central and peripheral mechanisms mediating the pathogenesis of sympathetic over-activity. Determination of the mechanisms by which exercise training improves cardiovascular function in disease.

- In vivo experiments in rodents with expertise in the measurement of blood pressure and sympathetic nerve activity during exercise

- Running wheel and treadmill exercise training - Immunohistochemistry and Western blotting

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Stachenfeld, Nina The John B. Pierce Laboratory, USA

Cardiovascular control Cardiovascular disease Oestrogens Polycystic ovary syndrome Hydration in women

Sex hormone effect on cardiovascular control and autonomic function. Fluid and sodium regulation and women’s health.

- Skin microdialysis - Microneurography - Baroreflex - Lower body negative pressure - Sex hormone administration and control - Models of sex hormone suppression

Szewczyk, Nathaniel University of Nottingham, UK

Muscle Muscle Molecular Medicine C. elegans Spaceflight Signal transduction Protein homeostasis Mitochondrial homeostasis Ageing Muscular dystrophies

Mechanisms underlying alteration of muscle mass, metabolism, and performance by nutrients, toxins, drugs, the genome, the environment, and with age and disease.

- Human subjects - Animal and invertebrate models - Cell culture - Spaceflight and unloading models - Microscopy - Forward and reverse genetics - Assessing pharmacological compounds, nutrients,

and toxins - Assessing neuromuscular signalling/excitation

contraction coupling - Assessing signal transduction - Assessing protein synthesis and degradation - Assessing mitochondrial structure and function - OMICs and validating techniques

Tan, Can Ozan Harvard Medical School, USA

Vascular Cerebral blood flow Neurovascular Exercise Sympathetic Autonomic Statistics Brain injury Stroke

Human cerebrovascular function in health and disease. Cardiac and vascular autonomic control. Sympathetic neurovascular transduction. Aerobic exercise to improve cardiovascular, cerebrovascular, and cognitive function.

- Transcranial Doppler ultrasound - Near Infrared Spectroscopy - Dual-Energy Computed Tomography - Microneurography - Baroreflex - Exercise testing - Computational and statistical modelling - Signal processing

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Tang, Haiyang University of Arizona, USA

Vascular Respiratory Pulmonary hypertension Acute lung injury Pulmonary fibrosis

Pathophysiology and pathogenic mechanisms of the development of pulmonary diseases including idiopathic pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, hypoxic or lung disease associated pulmonary hypertension, interstitial pulmonary fibrosis and acute lung injury.

- Right heart catheterisation - Hypoxic pulmonary vasoconstriction

measurement - Pulmonary hypertension animal models - Lung injury animal models - Pulmonary fibrosis animal models

Thijssen, Dick Radboud University, The Netherlands

Environmental and exercise Endothelin Exercise

Vascular adaptations to exercise and lifestyle interventions. Cardiovascular responses to inactivity, exercise and exercise training. Conduit, resistance and microvessel function and remodelling. Cardiac adaptations to exercise and training in humans.

- Vascular ultrasound - Plethysmography

Thomas, Gail Penn State Hershey Medical Center, USA

Autonomic neuroscience Cardiovascular control Blood flow Cardiovascular Nervous system Sympathetic Vascular

Regulation of blood pressure and skeletal muscle blood flow during exercise. Integration of sympathetic and metabolic signalling pathways to optimize blood flow in healthy skeletal muscle and the dysregulation of these pathways in disease states such as heart failure, hypertension, and muscular dystrophy.

- Rodent models of cardiovascular disease and muscular dystrophy

- In vivo assessment of cardiovascular function - Telemetry - Treadmill exercise - Blood flow measurements

Vianna, Lauro University of Brasília, Brazil

Environmental and exercise Exercise Afferents Blood pressure Arterial baroreflex Autonomic Nervous System Blood flow

Neural cardiovascular control mechanisms at rest and during exercise in healthy humans as well as patients with various pathophysiological conditions. Cerebral and peripheral vascular responses to exercise and other acute/chronic interventions.

- Microneurography - Doppler ultrasound - Transcranial Doppler - Flow-mediated dilation - Arterial stiffness - Non-invasive nerve stimulation - Modified Oxford technique - Autonomic function tests - Exercise testing

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Wainford, Richard Boston University, USA

Endocrinology Neuroscience Hypertension Neural control Renal sympathetic nerves Central Nervous System Autonomic Function Renal physiology Pharmacology

The integrated sympathetic nervous system and renal control of fluid and electrolyte homeostasis and blood pressure regulation.

- In vivo physiological measurement - Molecular and cellular biology - Autonomic function

Whim, Matthew Louisiana State University, USA

Endocrinology Autonomic nervous system Hypoglycaemia Chromaffin cells Adrenal medulla

Neuronal regulation of blood glucose levels, neuroendocrine response to stress and neuropeptide secretion.

- Slice and in vitro electrophysiology - Quantitative immunohistochemistry

Wilkinson, Daniel University of Nottingham, UK

Muscle Skeletal muscle Metabolism Mass Spectrometry Exercise and nutrition Ageing diseases

Control and regulation of skeletal muscle metabolism, with particular reference to ageing and disease. Application of innovative stable isotope tracer methodologies to understand the control of metabolism. Metabolomics and biomarkers relating to health, ageing and disease.

- Expertise in the application of novel stable isotope tracer techniques for understanding control of metabolism

- Mass spectrometry and metabolomics - Additional expertise in in vitro cell culture models

and human clinical physiology studies

Yamada, Takashi Sapporo Medical University, Japan

Muscle Muscle physiology Muscle weakness/fatigue Inflammation Oxidative stress Exercise

Investigating the mechanisms behind muscle adaptations in response to exercise and maladaptation in aging, as well as studying primary and secondary myopathies to develop novel therapeutic interventions to treat skeletal muscle weakness and fatigue. Researching the complex interactions between mechanical stress, force production, intracellular calcium handling, myofibrillar function, inflammation, and reactive oxygen/nitrogen species.

- In vivo torque analysis - In vitro force analysis - Skinned fibre force measurements - Neuromuscular electrical stimulation - Biochemistry - Histochemistry

Which Reviewing Editor?

Name and institution Subject area/keywords

Research interests Techniques

Yang, Kai Guangzhou Institute of Respiratory Health/Guangzhou Medical University, China

Respiratory Pulmonary hypertension Smooth muscle cells Endothelial cells Calcium ion channels Hypoxia

Mechanisms of pulmonary hypertension, including hypoxia, calcium ion channels, bone morphogenetic protein signalling and their links to the dysregulation in vascular smooth muscle and endothelial cells during disease pathogenesis.

- Animal models - Primary isolation of vascular smooth muscle and

endothelial cells - Calcium imaging - Molecular biology and biochemical techniques - Immunohistochemistry - Immunofluorescence

Yao, Song University of Melbourne, Australia

Heart/cardiac muscle Heart failure Myocardial infarction Neural inflammation

Neural mechanisms underlying cardiac function and cardiac remodelling after myocardial infarction. Understanding the role of the blood-brain barrier and inflammatory factors contributing to heart failure progression.

- In vivo recording of sympathetic nerve activity - Echocardiography - Tracing brain circuitry with neural tracers and

viruses - Immunohistochemistry and microscopy

Radiotelemetry Yu, Qiujun University of Pittsburgh, USA

Vascular Vascular biology and metabolism, Non-coding RNA Epigenetics

Non-coding RNAs and pulmonary vascular biology in pulmonary hypertension. Iron-sulfa cluster, metabolic and epigenetic regulation in vascular hypoxic adaptions. Myocardial metabolism, redox signalling, and coronary microcirculation in ischemic heart disease.

- In vitro studies of vascular biology - In vivo models of pulmonary hypertension - Ex vivo models of myocardial

ischemia/reperfusion - Mitochondrial metabolism - Redox signalling - Molecular biology