We’re Not Crazy! 6.25.14
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Transcript of We’re Not Crazy! 6.25.14
We’re Not Crazy, We’re Just a Little Unwell
Recognizing Abnormal Behavior in Laboratory Animals
But first…
• Certification Training• Training on MSDS Sheets• Basic Biotechniques such as gavaging, blood
draws, ear notching• How to operate the anesthesia and CO2 machines
What is Abnormal?
ab·nor·mal
adjective
Deviating from what is normal or usual, typically in a way that is undesirable or worrying
Abnormal Behavior
• Unusual/Strange• Not ordinary• Unexpected• Not Accepted• Disturbing• Deviant
Abnormal Animal Behavior
• Two Categories– Maladaptive– Malfunctional
Maladaptive
Malfunctional
Why Care?
• Not necessarily a ‘normal’ organism– Brain chemistry may be different– Issues with metabolism could be present– Blood parameters may be altered
• Unnatural behavior• Scientific data may be skewed• Data may be considered invalid
STRESS / DISTRESS
Comes in ALL Varieties
No more! Please!!
Anxiety
Anger
So, What’s a Lab Critter To Do?
Maladaptive Behavior
• Responsive behavior to the environment• Individual is not dealing with environment well• Humans– Turning to substance abuse– Avoidance behavior
• Animals– Infanticide– Avoidance behavior
Maladaptive
• Cannot adapt to environment• Exhibit inappropriate behavior
Fearful
• Due to current environment• Due to previous experiences• Two types– Aggressive Fear– Paralytic Fear
Aggressive Fear
Aggressive Fear
Paralytic Fear
United Kingdom Metro News
Self Directed Display
• Mouthing of limb– Does not break skin– Causes no injury
Malfunctional Behaviors• Abnormal brain chemistry or development
brought on by the environment• Humans– Stereotypic behavior– Compulsive disorders
• Animals– Stereotypic behaviors– Compulsive behaviors
Stereotypic Behavior
• Definition:– Unvarying inappropriate repetition
•Lacks a goal
The Classic Circle
Let’s Jump!
• And spin, and dig, and bar chew…
Salute
Compulsive Behavior
• Repetition of an inappropriate goal• THIS is where it gets UGLY
Overgrooming• Self explanatory• Varying degrees of severity
Barbering
Classic Hair Pullers
Classic Self Overgrooming
Itchy Mouse Syndrome
• To the point of irritation/infection!
Self Injurious Behavior (SIB)
• Self explanatory• Varying degrees of severity• Really really ugly…
“Bailey in bandages” – c. Susan Cleghorn
SIB
BAD
WORSE
Floating Limb
• While sitting passively, a limb performs an involuntary, upward movement
• Activity may last from a few seconds to several minutes
• Really Really REALLY ugly…
Floating Limb
Non-aggressive Aggressive (with bite)
Active Floating Limb With Bite
No Rest for the Weary…
When is Abnormal Normal?
Innate Behaviors
• Protection of young• Imprinting in baby birds
Transgenic & Knockout Phenotypes
• Grooming and appearance• Home cage behaviors– Nesting/huddling– Fighting– Stereotypical behaviors– Altered sleep patters
• Reaction to handling• Motor insufficenies
Wiley-Liss, 2000
Quick Example
University of Kansas Medical University of Kansas Medical CenterCenter
Even Hairloss!
Dr. Gabriel DiMattia – University of Western Ontario Dept. of OncologyDr. Gabriel DiMattia – University of Western Ontario Dept. of Oncology
Love
Additional Photo Credits
• Viktor Reinhardt, DVM, PhD• Kathy Benson, PhD• Jim Weed, PhD• Dawn Abney• Hanno Wurbel, PhD• Joe Garner, PhD• Online Elephant Encyclopedia
FIN
ANY QUESTIONS??