WEEKLY REPORT ON SARS-CoV-2 POSITIVE PATIENTS ......2021/04/09 · • 911 of the 9,932 (9.2%)...

WEEKLY REPORT ON SARS-CoV-2 POSITIVE PATIENTS IN TRANSPLANTATION

REPORT FOR 1 MARCH 2020 – 7 APRIL 2021

PUBLISHED 9 APRIL 2021

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This report has been produced by Statistics and Clinical Studies, NHS Blood and Transplant. All figures quoted in this report are as reported to NHS Blood and Transplant by 7 April 2021. This report contains information on all patients registered with NHS Blood and Transplant active on the waiting list for an organ transplant or in follow-up after receiving an organ transplant that

have tested positive for SARS-CoV-2. The data collected are deliberately limited so as not to add significantly to the burden of work in transplant centres. Information on the vital status of a patient has been supplemented from the NHS Digital Tracing Service for patients who reside in England and Wales. Only deaths reported within 28 days of a positive test result are included. All English patients on the UK Transplant Registry on the waiting list and post-transplant have been linked with Public Health England to obtain whether a patient has tested positive for

SARS-CoV-2. This data is updated on a weekly basis. All Scottish patients on the UK Transplant Registry on the waiting list and post-transplant have been linked with Public Health Scotland to obtain whether a patient has tested positive for

SARS-CoV-2. This data is updated on a monthly basis Detailed breakdown by organ is possible for kidney, SPK, liver, heart and lung transplants only due to small numbers. Further analysis is planned in future reports to include univariate and multi-variable analysis. Caveats

Data are only reported for patients that have tested positive for SARS-CoV-2, patients that may have CoVID-19 but were not tested are not available for analysis. During the period in question, SARS-CoV-2 swab testing was in the main restricted to patients presenting to hospital and as such there is a selection bias towards symptomatic, sicker patients. Cause of death information is not available at this time and therefore recent deaths should not be assumed secondary to COVID-19. Data linkage has only been possible so far for English and Scottish patients, we are working with other UK nations to get a data linkage in place as soon as possible. Supplemented death data is only reported for English and Welsh patients and includes all causes of death. For other UK nations we are reliant on the return of centre reported follow-up information.

Acknowledgements NHS Blood and Transplant would like to thank all those responsible for providing data to the NHSBT CoVID-19 Registry, without whom this report would not be possible. We would also like to thank Richard Little at NHSBT who has largely contributed to obtaining the death information from the NHS Digital Tracing Service.

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We would also like to thank Ines Ushiro-Lumb (NHSBT), Rommel Ravanan (Kidney Advisory Group Chair) and James Thomas (PHE) who have largely contributed to obtaining information

on positive test results for SARS-CoV-2 from Public Health England.

We would also like to thank Hester Ward (National Services Scotland) and Alison Smith-Palmer (PHS) who have largely contributed to obtaining information on positive test results for

SARS-CoV-2 from Public Health Scotland. Publications

https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16247?af=R

https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16247?af=R

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Executive Summary

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Key Findings

• The number of deceased donor transplants fell from 80 transplants performed in one week at the beginning of March to just 8 at the end of March. Deceased donor transplants are now nearing normal figures, with 88 transplants performed in the week commencing 29 March 2021.

• 3,749 of the 58,181 (6.4%) recipients with a functioning graft are reported as testing positive for SARS-CoV-2. Of these, 17% (n=633) are reported as died as at 24 March 2021.

• The infection rate across England ranges from 3.8% in the South West to 10.3% in London in recipients with a functioning graft.

• 911 of the 9,932 (9.2%) patients on the active waiting list at 1 February 2020 and new registrations since 1 February 2020 are reported as testing positive for SARS-CoV-2. Of these, 8% (n=74) are reported as died as at 24 March 2021.

• The infection rate across England ranges from 3.7% in the South west to 18.0% in London for patients on the active waiting list.

• Of the 4,389 transplants performed so far in 2020 and 2021, 302 (6.9%) recipients have tested positive for SARS-CoV-2 with 43 (1.0%) reported as died.

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Figure 1 shows the number of donors and transplants by week and donor type since

Monday 6th January 2020.

Figure 2 shows the cumulative incidence of SARS-CoV-2 positive patients and the

cumulative deaths by week separately for transplanted recipients and active wait listed

patients since Monday 3 February 2020.

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Figure 1 Effect CoVID-19 has on Deceased Donation and Transplantation

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+ve Waiting list patients+ve Transplant recipients

Figure 2 Cumulative incidence of SARS-CoV-2 positive patients

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Figure 3 shows the incidence and deaths of SARS-CoV-2 positive patients by organ for

transplanted recipients and active wait listed patients.

Table 1 shows the number of NHSBT CoVID-19 initial presentation forms returned and the

number of NHSBT CoVID-19 follow-up forms returned for transplant recipients and wait

listed patients by organ. Total cases include the number of positive SARS-CoV-2 patients

in England that have been collected through the PHE data link. Please note that for

patients residing in England and Wales the vital status of a patient is checked using the

NHS Digital Tracing Service.

Table 1 Form return rates for Initial and Follow-up as at 17 March 2021

Transplant Recipients Waiting list patients Total +ve

cases known to NHSBT1

Initial forms

returned

Follow-up forms

returned

Total +ve cases

known to NHSBT1

Initial forms

returned

Follow-up forms

returned

Kidney 2859 759 390 716 102 42 SPK 106 37 17 38 6 2 Pancreas / Islet 20 5 1 0 0 0 Liver 492 55 23 61 7 5 Heart 111 46 17 33 10 2 Lung 99 63 6 16 5 2 Intestinal 10 1 0 1 0 0 Multi-organ 10 1 1 1 0 0 Total 3707 967 455 866 130 53 1 Total positive cases include those reported by Public Heath England

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Deaths in +ve transplant recipients+ve Transplant recipientsDeaths in +ve w aiting list patients+ve Waiting list patients

Figure 3 Incidence and death of SARS-CoV-2 positive patients

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Table 2 shows the number of organ transplant recipients that were alive with a functioning

graft at 1 February 2020 by type of organ transplant and NHS Region.

Table 2 Number of recipients with a functioning graft by transplant type and NHS Region, as at 1 February 2020 including transplants after 1 February 2020

Kidney SPK Pancreas Liver Heart Lung Intestinal Multi organ Total

North East and Yorkshire 5321 151 44 1401 436 229 19 24 7625 North West 4132 141 25 1083 267 158 20 21 5847 Midlands 5828 323 51 1696 436 245 23 33 8635 East of England 3745 236 16 1140 293 209 24 27 5692 London 6346 215 29 1628 291 151 20 43 8724 South East 4951 305 29 1267 329 234 16 30 7161 South West 3296 143 61 858 218 131 9 20 4736 Northern Ireland 1439 24 5 353 68 43 8 2 1942 Scotland 3474 177 59 1132 229 118 9 12 5210 Wales 1885 105 27 399 115 71 3 4 2609 TOTAL 40417 1820 346 10957 2682 1589 151 216 58181

Table 3 shows the number of organ transplant recipients that have tested positive for

SARS-CoV-2 by type of organ transplant and NHS Region. In total, 3,749 organ transplant

recipients have been reported to NHSBT as testing positive for SARS-CoV-2. Of these, 633

(17%) have died.

Table 3 Number of recipients testing positve for SARS-CoV-2 by transplant type and NHS Region, data up to 7 April 2021

Kidney SPK Pancreas Liver Heart Lung Intestinal Multi organ Total Died

North East and Yorkshire 399 5 5 63 28 16 1 0 517 81 North West 395 12 2 83 14 23 1 3 533 103 Midlands 538 21 2 92 28 18 2 2 703 104 East of England 258 12 1 42 5 8 1 1 328 72 London 715 23 4 122 16 14 4 2 900 149 South East 329 26 1 65 13 9 0 2 445 63 South West 136 5 4 24 7 3 1 1 181 35 Northern Ireland 9 0 0 0 0 0 0 0 9 2 Scotland 40 1 1 3 0 2 1 0 48 10 Wales 73 2 0 1 2 7 0 0 85 14 TOTAL 2892 107 20 495 113 100 11 11 3749 633

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Table 4 shows the number of recipients on the active waiting list at 1 February 2020 by type of organ transplant and NHS Region.

Table 4 Number of patients on the active waiting list by organ awaited and NHS Region, as at 1 February 2020 including new regsitrations since 1 February 2020

Kidney SPK Pancreas Liver Heart Lung Intestinal Multi organ Total

North East and Yorkshire 886 40 8 171 118 85 3 7 1318 North West 797 33 4 161 51 58 2 4 1110 Midlands 1162 65 6 218 100 95 3 4 1653 East of England 536 25 1 136 55 40 2 4 799 London 1401 37 1 191 70 56 3 6 1765 South East 625 40 4 171 68 57 3 7 975 South West 472 25 2 114 39 42 1 2 697 Northern Ireland 231 2 0 61 28 26 0 0 348 Scotland 616 41 6 144 50 41 0 1 899 Wales 250 19 0 57 18 24 0 0 368 TOTAL 6976 327 32 1424 597 524 17 35 9932

Table 5 shows the number of active wait listed patients that have tested positive for SARS-CoV-2 by type or organ awaited and NHS Region. In total, 911 patients have been reported to NHSBT as testing positive for SARS-CoV-2. Of these, 74 (8%) have died.

Table 5 Number of patients testing positive for SARS-CoV-2 by organ awaited and NHS Region, data up to 7 April 2021

Kidney SPK Liver Heart Lung Intestinal Multi-organ

Total Died

North East and Yorkshire 70 3 13 6 4 0 0 96 6 North West 104 3 12 9 2 0 0 130 11 Midlands 118 8 14 8 4 0 1 153 19 East of England 68 6 5 1 1 1 0 82 2 London 283 12 15 5 3 0 0 318 26 South East 69 3 13 3 2 0 0 90 7 South West 17 3 3 2 1 0 0 26 2 Scotland 7 1 1 0 1 0 0 10 0 Wales 5 0 0 1 0 0 0 6 1 TOTAL 741 39 76 35 18 1 1 911 74

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Table 6 shows the demographic characteristics of organ transplant recipients. The

information reported are those with a functioning transplant at 1 February 2020, those

testing positive for SARS-CoV-2 and of those testing positive, the number that have died.

Table 6 Demographic characteristics of transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021

Functioning graft SARS-CoV-2 +ve cases SARS-CoV-2 +ve deaths

Factor Level N % N %

% of functioning

graft N % of

cases

% of functioning

graft

Sex Male 35256 60.6 2291 61.1 6.5 415 18.1 1.2 Female 22897 39.4 1458 38.9 6.4 218 15.0 1.0 Unknown 28 0.0 - - - - - -

Blood Group

O 25100 43.2 1426 38.0 5.7 231 16.2 0.9 A 23387 40.2 1541 41.1 6.6 259 16.8 1.1 B 7147 12.3 584 15.6 8.2 104 17.8 1.5 AB 2528 4.3 198 5.3 7.8 39 19.7 1.5

Ethnicity White 44777 77.0 2333 62.2 5.2 380 16.3 0.8 Asian 6008 10.3 819 21.8 13.6 137 16.7 2.3 Black 2837 4.9 311 8.3 11.0 68 21.9 2.4 Other 1462 2.5 124 3.3 8.5 17 13.7 1.2 Unknown 3097 5.3 162 4.3 5.2 31 19.1 1.0

Age group

0-17 2160 3.7 85 2.3 3.9 - - - 18-29 3667 6.3 270 7.2 7.4 4 1.5 0.1 30-39 5932 10.2 403 10.8 6.8 18 4.5 0.3 40-49 9166 15.8 620 16.5 6.8 43 6.9 0.5 50-59 14832 25.5 1002 26.7 6.8 143 14.3 1.0 60-69 14022 24.1 886 23.6 6.3 214 24.2 1.5 >70 8395 14.4 481 12.8 5.7 211 43.9 2.5

Organ Kidney 40417 69.5 2892 77.1 7.2 496 17.2 1.2 SPK 1820 3.1 107 2.9 5.9 13 12.1 0.7 Pancreas 346 0.6 20 0.5 5.8 4 20.0 1.2 Liver 10957 18.8 495 13.2 4.5 66 13.3 0.6 Heart 2682 4.6 113 3.0 4.2 22 19.5 0.8 Lung 1589 2.7 100 2.7 6.3 29 29.0 1.8 Intestinal 151 0.3 11 0.3 7.3 1 9.1 0.7 Multi organ 216 0.4 11 0.3 5.1 2 18.2 0.9

NHS Region

North East and Yorks

7625 13.1 517 13.8 6.8 81 15.7 1.1

North West 5847 10.0 533 14.2 9.1 103 19.3 1.8 Midlands 8635 14.8 703 18.8 8.1 104 14.8 1.2 East of England

5692 9.8 328 8.7 5.8 72 22.0 1.3

London 8724 15.0 900 24.0 10.3 149 16.6 1.7 South East 7161 12.3 445 11.9 6.2 63 14.2 0.9 South West 4736 8.1 181 4.8 3.8 35 19.3 0.7 Northern Ireland

1942 3.3 9 0.2 0.5 2 22.2 0.1

Scotland 5210 9.0 48 1.3 0.9 10 20.8 0.2 Wales 2609 4.5 85 2.3 3.3 14 16.5 0.5

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Table 6 Demographic characteristics of transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft Year of transplant

<=2015 36631 63.0 2225 59.3 6.1 411 18.5 1.1 2016 3835 6.6 240 6.4 6.3 41 17.1 1.1 2017 4165 7.2 292 7.8 7.0 42 14.4 1.0 2018 4519 7.8 310 8.3 6.9 43 13.9 1.0 2019 4642 8.0 380 10.1 8.2 53 13.9 1.1 2020 3601 6.2 294 7.8 8.2 43 14.6 1.2 2021 788 1.4 8 0.2 1.0 - - -

Time from transplant

0-3 months - - 144 3.8 - 25 17.4 - 3-6 months - - 104 2.8 - 17 16.3 - 6-12 months

- - 133 3.5 - 18 13.5 -

12+ months - - 3368 89.8 - 573 17.0 -

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Table 7 shows the demographic characteristics of patients waiting for an organ transplant.

The information reported are those active on the waiting list at 1 February 2020, those


Table 7 Demographic characteristics of active patients on the waiting list testing postive for SARS-CoV-2, data up to 7 April 2021

Active on waiting list SARS-CoV-2 +ve cases SARS-CoV-2 +ve deaths


% of waiting

list N % of

cases

% of waiting

list


Blood Group

O 5033 50.7 436 47.9 8.7 37 8.5 0.7 A 3001 30.2 231 25.4 7.7 17 7.4 0.6 B 1592 16.0 213 23.4 13.4 20 9.4 1.3 AB 306 3.1 31 3.4 10.1 - - -


Age group

0-17 439 4.4 30 3.3 6.8 1 3.3 0.2 18-29 699 7.0 55 6.0 7.9 2 3.6 0.3 30-39 1246 12.5 119 13.1 9.6 4 3.4 0.3 40-49 1838 18.5 188 20.6 10.2 11 5.9 0.6 50-59 2866 28.9 267 29.3 9.3 16 6.0 0.6 60-69 2244 22.6 202 22.2 9.0 35 17.3 1.6 >70 600 6.0 50 5.5 8.3 5 10.0 0.8

Organ Kidney 6976 70.2 741 81.3 10.6 54 7.3 0.8 SPK 327 3.3 39 4.3 11.9 4 10.3 1.2 Pancreas 32 0.3 - - - - - - Liver 1424 14.3 76 8.3 5.3 9 11.8 0.6 Heart 597 6.0 35 3.8 5.9 2 5.7 0.3 Lung 524 5.3 18 2.0 3.4 5 27.8 1.0 Intestinal 17 0.2 1 0.1 5.9 - - - Multi organ 35 0.4 1 0.1 2.9 - - -

NHS Region


1318 13.3 96 10.5 7.3 6 6.3 0.5


799 8.0 82 9.0 10.3 2 2.4 0.3


348 3.5 - - - - - -

Scotland 899 9.1 10 1.1 1.1 - - - Wales 368 3.7 6 0.7 1.6 1 16.7 0.3

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Kidney

- 14 -

Table 8 shows the demographic characteristics of kidney only transplant recipients. The



Table 8 Demographic characteristics of kidney transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft


Blood Group

O 17545 43.4 1106 38.2 6.3 184 16.6 1.0 A 15960 39.5 1183 40.9 7.4 199 16.8 1.2 B 5118 12.7 448 15.5 8.8 86 19.2 1.7 AB 1778 4.4 155 5.4 8.7 27 17.4 1.5


Age group

0-17 907 2.2 47 1.6 5.2 - - - 18-29 2346 5.8 185 6.4 7.9 3 1.6 0.1 30-39 4243 10.5 320 11.1 7.5 10 3.1 0.2 40-49 6725 16.6 494 17.1 7.3 35 7.1 0.5 50-59 10705 26.5 788 27.3 7.4 113 14.3 1.1 60-69 9384 23.2 673 23.3 7.2 163 24.2 1.7 >70 6107 15.1 384 13.3 6.3 172 44.8 2.8

Organ Kidney 40417 100.0 2892 100.0 7.2 496 17.2 1.2

NHS Region


5321 13.2 399 13.8 7.5 62 15.5 1.2


3745 9.3 258 8.9 6.9 61 23.6 1.6


1439 3.6 9 0.3 0.6 2 22.2 0.1

Scotland 3474 8.6 40 1.4 1.2 9 22.5 0.3 Wales 1885 4.7 73 2.5 3.9 10 13.7 0.5

Year of transplant

<=2015 25422 62.9 1715 59.3 6.7 315 18.4 1.2 2016 2671 6.6 187 6.5 7.0 31 16.6 1.2 2017 2910 7.2 227 7.8 7.8 33 14.5 1.1 2018 3145 7.8 240 8.3 7.6 37 15.4 1.2 2019 3307 8.2 286 9.9 8.6 43 15.0 1.3 2020 2442 6.0 231 8.0 9.5 37 16.0 1.5 2021 520 1.3 6 0.2 1.2 - - -

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Table 8 Demographic characteristics of kidney transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft Time from transplant


- - 104 3.6 - 13 12.5 -

12+ months - - 2595 89.7 - 445 17.1 -

- 16 -

Table 9 shows the demographic characteristics of patients waiting for a kidney transplant.



Table 9 Demographic characteristics of active kidney patients on the waiting list testing postive for SARS-CoV-2, data up to 7 April 2021



% of waiting

list N % of

cases

% of waiting

list


Blood Group

O 3619 51.9 357 48.2 9.9 26 7.3 0.7 A 1913 27.4 180 24.3 9.4 11 6.1 0.6 B 1236 17.7 179 24.2 14.5 17 9.5 1.4 AB 208 3.0 25 3.4 12.0 - - -


Age group

0-17 190 2.7 15 2.0 7.9 - - - 18-29 464 6.7 39 5.3 8.4 1 2.6 0.2 30-39 845 12.1 83 11.2 9.8 2 2.4 0.2 40-49 1300 18.6 151 20.4 11.6 5 3.3 0.4 50-59 1986 28.5 219 29.6 11.0 10 4.6 0.5 60-69 1625 23.3 186 25.1 11.4 31 16.7 1.9 >70 566 8.1 48 6.5 8.5 5 10.4 0.9

Organ Kidney 6976 100.0 741 100.0 10.6 54 7.3 0.8

NHS Region


886 12.7 70 9.4 7.9 4 5.7 0.5


536 7.7 68 9.2 12.7 2 2.9 0.4


231 3.3 - - - - - -

Scotland 616 8.8 7 0.9 1.1 - - - Wales 250 3.6 5 0.7 2.0 1 20.0 0.4

- 17 -

SPK

- 18 -

Table 10 shows the demographic characteristics of SPK transplant recipients. The



Table 10 Demographic characteristics of SPK transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft

Sex Male 1058 58.1 65 60.7 6.1 9 13.8 0.9 Female 762 41.9 42 39.3 5.5 4 9.5 0.5

Blood Group

O 793 43.6 47 43.9 5.9 4 8.5 0.5 A 753 41.4 37 34.6 4.9 4 10.8 0.5 B 193 10.6 17 15.9 8.8 2 11.8 1.0 AB 81 4.5 6 5.6 7.4 3 50.0 3.7

Ethnicity White 1601 88.0 83 77.6 5.2 8 9.6 0.5 Asian 101 5.5 12 11.2 11.9 4 33.3 4.0 Black 79 4.3 10 9.3 12.7 1 10.0 1.3 Other 21 1.2 - - - - - - Unknown 18 1.0 2 1.9 11.1 - - -

Age group

0-17 - - - - - - - - 18-29 36 2.0 1 0.9 2.8 - - - 30-39 305 16.8 13 12.1 4.3 1 7.7 0.3 40-49 604 33.2 31 29.0 5.1 2 6.5 0.3 50-59 647 35.5 47 43.9 7.3 8 17.0 1.2 60-69 213 11.7 13 12.1 6.1 - - - >70 15 0.8 2 1.9 13.3 2 100.0 13.3

Organ SPK 1820 100.0 107 100.0 5.9 13 12.1 0.7

NHS Region


151 8.3 5 4.7 3.3 - - -


236 13.0 12 11.2 5.1 2 16.7 0.8

London 215 11.8 23 21.5 10.7 4 17.4 1.9 South East 305 16.8 26 24.3 8.5 2 7.7 0.7 South West 143 7.9 5 4.7 3.5 - - - Northern Ireland

24 1.3 - - - - - -

Scotland 177 9.7 1 0.9 0.6 - - - Wales 105 5.8 2 1.9 1.9 - - -

Year of transplant

<=2015 1118 61.4 59 55.1 5.3 8 13.6 0.7 2016 123 6.8 6 5.6 4.9 1 16.7 0.8 2017 147 8.1 12 11.2 8.2 1 8.3 0.7 2018 159 8.7 10 9.3 6.3 1 10.0 0.6 2019 150 8.2 10 9.3 6.7 - - - 2020 98 5.4 8 7.5 8.2 2 25.0 2.0 2021 25 1.4 2 1.9 8.0 - - -

- 19 -

Table 10 Demographic characteristics of SPK transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning


0-3 months - - 6 5.6 - - - - 3-6 months - - 2 1.9 - - - - 6-12 months

- - 4 3.7 - 2 50.0 -

12+ months - - 95 88.8 - 11 11.6 -

- 20 -

Table 11 shows the demographic characteristics of patients waiting for an SPK transplant.



Table 11 Demographic characteristics of active SPK patients on the waiting list testing postive for SARS-CoV-2, data up to 7 April 2021



% of waiting

list N % of

cases

% of waiting

list

Sex Male 179 54.7 19 48.7 10.6 2 10.5 1.1 Female 148 45.3 20 51.3 13.5 2 10.0 1.4

Blood Group

O 146 44.6 19 48.7 13.0 4 21.1 2.7 A 119 36.4 9 23.1 7.6 - - - B 50 15.3 9 23.1 18.0 - - - AB 12 3.7 2 5.1 16.7 - - -

Ethnicity White 275 84.1 24 61.5 8.7 2 8.3 0.7 Asian 27 8.3 6 15.4 22.2 1 16.7 3.7 Black 16 4.9 5 12.8 31.3 - - - Other 8 2.4 3 7.7 37.5 - - - Unknown 1 0.3 1 2.6 100.0 1 100.0 100.0

Age group

0-17 1 0.3 1 2.6 100.0 - - - 18-29 27 8.3 2 5.1 7.4 - - - 30-39 115 35.2 13 33.3 11.3 1 7.7 0.9 40-49 105 32.1 13 33.3 12.4 2 15.4 1.9 50-59 74 22.6 10 25.6 13.5 1 10.0 1.4 60-69 5 1.5 - - - - - - >70 - - - - - - - -

Organ SPK 327 100.0 39 100.0 11.9 4 10.3 1.2

NHS Region


40 12.2 3 7.7 7.5 - - -

North West 33 10.1 3 7.7 9.1 - - - Midlands 65 19.9 8 20.5 12.3 2 25.0 3.1 East of England

25 7.6 6 15.4 24.0 - - -

London 37 11.3 12 30.8 32.4 2 16.7 5.4 South East 40 12.2 3 7.7 7.5 - - - South West 25 7.6 3 7.7 12.0 - - - Northern Ireland

2 0.6 - - - - - -

Scotland 41 12.5 1 2.6 2.4 - - - Wales 19 5.8 - - - - - -

- 21 -

Liver

- 22 -

Table 12 shows the demographic characteristics of liver transplant recipients. The



Table 12 Demographic characteristics of liver transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft


Blood Group

O 4742 43.3 187 37.8 3.9 25 13.4 0.5 A 4439 40.5 201 40.6 4.5 29 14.4 0.7 B 1315 12.0 82 16.6 6.2 7 8.5 0.5 AB 461 4.2 25 5.1 5.4 5 20.0 1.1

Ethnicity White 9137 83.4 356 71.9 3.9 50 14.0 0.5 Asian 951 8.7 97 19.6 10.2 11 11.3 1.2 Black 333 3.0 22 4.4 6.6 4 18.2 1.2 Other 256 2.3 10 2.0 3.9 - - - Unknown 280 2.6 10 2.0 3.6 1 10.0 0.4

Age group

0-17 877 8.0 26 5.3 3.0 - - - 18-29 814 7.4 61 12.3 7.5 - - - 30-39 779 7.1 39 7.9 5.0 1 2.6 0.1 40-49 1117 10.2 57 11.5 5.1 3 5.3 0.3 50-59 2369 21.6 101 20.4 4.3 8 7.9 0.3 60-69 3262 29.8 138 27.9 4.2 24 17.4 0.7 >70 1732 15.8 72 14.6 4.2 30 41.7 1.7

Organ Liver 10957 100.0 495 100.0 4.5 66 13.3 0.6

NHS Region


1401 12.8 63 12.7 4.5 13 20.6 0.9


1140 10.4 42 8.5 3.7 3 7.1 0.3


353 3.2 - - - - - -

Scotland 1132 10.3 3 0.6 0.3 1 33.3 0.1 Wales 399 3.6 1 0.2 0.3 1 100.0 0.3

Year of transplant

<=2015 6814 62.2 306 61.8 4.5 51 16.7 0.7 2016 731 6.7 26 5.3 3.6 4 15.4 0.5 2017 786 7.2 36 7.3 4.6 4 11.1 0.5 2018 865 7.9 40 8.1 4.6 1 2.5 0.1 2019 829 7.6 47 9.5 5.7 5 10.6 0.6 2020 759 6.9 40 8.1 5.3 1 2.5 0.1 2021 173 1.6 - - - - - -

- 23 -

Table 12 Demographic characteristics of liver transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning



- - 13 2.6 - 2 15.4 -

12+ months - - 447 90.3 - 62 13.9 -

- 24 -

Table 13 shows the demographic characteristics of patients waiting for a liver transplant.



Table 13 Demographic characteristics of active liver patients on the waiting list testing postive for SARS-CoV-2, data up to 7 April 2021



% of waiting

list N % of

cases

% of waiting

list

Sex Male 852 59.8 44 57.9 5.2 4 9.1 0.5 Female 572 40.2 32 42.1 5.6 5 15.6 0.9 Unknown - - - - - - - -

Blood Group

O 663 46.6 35 46.1 5.3 4 11.4 0.6 A 531 37.3 24 31.6 4.5 3 12.5 0.6 B 181 12.7 16 21.1 8.8 2 12.5 1.1 AB 49 3.4 1 1.3 2.0 - - -

Ethnicity White 1175 82.5 54 71.1 4.6 7 13.0 0.6 Asian 128 9.0 13 17.1 10.2 1 7.7 0.8 Black 41 2.9 5 6.6 12.2 1 20.0 2.4 Other 39 2.7 2 2.6 5.1 - - - Unknown 41 2.9 2 2.6 4.9 - - -

Age group

0-17 133 9.3 9 11.8 6.8 1 11.1 0.8 18-29 115 8.1 10 13.2 8.7 1 10.0 0.9 30-39 133 9.3 12 15.8 9.0 1 8.3 0.8 40-49 253 17.8 14 18.4 5.5 3 21.4 1.2 50-59 411 28.9 23 30.3 5.6 2 8.7 0.5 60-69 353 24.8 6 7.9 1.7 1 16.7 0.3 >70 26 1.8 2 2.6 7.7 - - -

Organ Liver 1424 100.0 76 100.0 5.3 9 11.8 0.6

NHS Region


171 12.0 13 17.1 7.6 1 7.7 0.6


136 9.6 5 6.6 3.7 - - -


61 4.3 - - - - - -

Scotland 144 10.1 1 1.3 0.7 - - - Wales 57 4.0 - - - - - -

- 25 -

Heart

- 26 -

Table 14 shows the demographic characteristics of heart transplant recipients. The



Table 14 Demographic characteristics of heart transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft


Blood Group

O 1037 38.7 38 33.6 3.7 8 21.1 0.8 A 1201 44.8 55 48.7 4.6 10 18.2 0.8 B 325 12.1 15 13.3 4.6 3 20.0 0.9 AB 117 4.4 5 4.4 4.3 1 20.0 0.9

Ethnicity White 2167 80.8 83 73.5 3.8 16 19.3 0.7 Asian 206 7.7 15 13.3 7.3 4 26.7 1.9 Black 79 2.9 8 7.1 10.1 1 12.5 1.3 Other 49 1.8 2 1.8 4.1 1 50.0 2.0 Unknown 181 6.7 5 4.4 2.8 - - -

Age group

0-17 275 10.3 5 4.4 1.8 - - - 18-29 299 11.1 13 11.5 4.3 1 7.7 0.3 30-39 313 11.7 15 13.3 4.8 5 33.3 1.6 40-49 337 12.6 16 14.2 4.7 - - - 50-59 496 18.5 25 22.1 5.0 3 12.0 0.6 60-69 553 20.6 21 18.6 3.8 8 38.1 1.4 >70 409 15.2 18 15.9 4.4 5 27.8 1.2

Organ Heart 2682 100.0 113 100.0 4.2 22 19.5 0.8

NHS Region


436 16.3 28 24.8 6.4 3 10.7 0.7


293 10.9 5 4.4 1.7 2 40.0 0.7


68 2.5 - - - - - -

Scotland 229 8.5 - - - - - - Wales 115 4.3 2 1.8 1.7 1 50.0 0.9

Year of transplant

<=2015 1878 70.0 68 60.2 3.6 12 17.6 0.6 2016 161 6.0 10 8.8 6.2 2 20.0 1.2 2017 145 5.4 8 7.1 5.5 4 50.0 2.8 2018 144 5.4 8 7.1 5.6 - - - 2019 153 5.7 14 12.4 9.2 2 14.3 1.3 2020 167 6.2 5 4.4 3.0 2 40.0 1.2 2021 34 1.3 - - - - - -

- 27 -

Table 14 Demographic characteristics of heart transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning



- - 5 4.4 - - - -

12+ months - - 102 90.3 - 20 19.6 -

- 28 -

Table 15 shows the demographic characteristics of patients waiting for a heart transplant.



Table 15 Demographic characteristics of active heart patients on the waiting list testing postive for SARS-CoV-2, data up to 7 April 2021



% of waiting

list N % of

cases

% of waiting

list

Sex Male 428 71.7 25 71.4 5.8 - - - Female 169 28.3 10 28.6 5.9 - - - Unknown - - - - - - - -

Blood Group

O 282 47.2 13 37.1 4.6 - - - A 226 37.9 13 37.1 5.8 - - - B 64 10.7 6 17.1 9.4 - - - AB 25 4.2 3 8.6 12.0 - - -

Ethnicity White 497 83.2 25 71.4 5.0 - - - Asian 59 9.9 7 20.0 11.9 - - - Black 25 4.2 2 5.7 8.0 - - - Other 8 1.3 - - - - - - Unknown 8 1.3 1 2.9 12.5 - - -

Age group

0-17 86 14.4 2 5.7 2.3 - - - 18-29 42 7.0 3 8.6 7.1 - - - 30-39 74 12.4 7 20.0 9.5 - - - 40-49 90 15.1 7 20.0 7.8 - - - 50-59 190 31.8 9 25.7 4.7 - - - 60-69 108 18.1 7 20.0 6.5 - - - >70 7 1.2 - - - - - -

Organ Heart 597 100.0 35 100.0 5.9 2 5.7 0.3

NHS Region


118 19.8 6 17.1 5.1 - - -

North West 51 8.5 9 25.7 17.6 - - - Midlands 100 16.8 8 22.9 8.0 - - - East of England

55 9.2 1 2.9 1.8 - - -

London 70 11.7 5 14.3 7.1 - - - South East 68 11.4 3 8.6 4.4 - - - South West 39 6.5 2 5.7 5.1 - - - Northern Ireland

28 4.7 - - - - - -

Scotland 50 8.4 - - - - - - Wales 18 3.0 1 2.9 5.6 - - -

- 29 -

Lung

- 30 -

Table 16 shows the demographic characteristics of lung transplant recipients. The



Table 16 Demographic characteristics of lung transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning

graft


Blood Group

O 679 42.7 35 35.0 5.2 8 22.9 1.2 A 721 45.4 46 46.0 6.4 14 30.4 1.9 B 125 7.9 13 13.0 10.4 4 30.8 3.2 AB 64 4.0 6 6.0 9.4 3 50.0 4.7

Ethnicity White 1491 93.8 89 89.0 6.0 25 28.1 1.7 Asian 41 2.6 6 6.0 14.6 2 33.3 4.9 Black 12 0.8 2 2.0 16.7 - - - Other 11 0.7 3 3.0 27.3 2 66.7 18.2 Unknown 34 2.1 - - - - - -

Age group

0-17 31 2.0 3 3.0 9.7 - - - 18-29 125 7.9 9 9.0 7.2 - - - 30-39 222 14.0 14 14.0 6.3 1 7.1 0.5 40-49 251 15.8 14 14.0 5.6 2 14.3 0.8 50-59 398 25.0 31 31.0 7.8 10 32.3 2.5 60-69 462 29.1 27 27.0 5.8 16 59.3 3.5 >70 100 6.3 2 2.0 2.0 - - -

Organ Lung 1589 100.0 100 100.0 6.3 29 29.0 1.8

NHS Region


229 14.4 16 16.0 7.0 1 6.3 0.4


209 13.2 8 8.0 3.8 4 50.0 1.9


43 2.7 - - - - - -

Scotland 118 7.4 2 2.0 1.7 - - - Wales 71 4.5 7 7.0 9.9 2 28.6 2.8

Year of transplant

<=2015 951 59.8 52 52.0 5.5 20 38.5 2.1 2016 97 6.1 9 9.0 9.3 3 33.3 3.1 2017 134 8.4 5 5.0 3.7 - - - 2018 144 9.1 8 8.0 5.6 2 25.0 1.4 2019 138 8.7 18 18.0 13.0 3 16.7 2.2 2020 97 6.1 8 8.0 8.2 1 12.5 1.0 2021 28 1.8 - - - - - -

- 31 -

Table 16 Demographic characteristics of lung transplant patients testing postive for SARS-CoV-2, data up to 7 April 2021



% of functioning

graft N % of

cases

% of functioning


0-3 months - - 4 4.0 - - - - 6-12 months

- - 5 5.0 - 1 20.0 -

12+ months - - 91 91.0 - 28 30.8 -

- 32 -

Table 17 shows the demographic characteristics of patients waiting for a lung transplant.



Table 17 Demographic characteristics of active lung patients on the waiting list testing postive for SARS-CoV-2, data up to 7 April 2021



% of waiting

list N % of

cases

% of waiting

list


Blood Group

O 276 52.7 11 61.1 4.0 2 18.2 0.7 A 190 36.3 4 22.2 2.1 2 50.0 1.1 B 48 9.2 3 16.7 6.3 1 33.3 2.1 AB 10 1.9 - - - - - -

Ethnicity White 467 89.1 15 83.3 3.2 3 20.0 0.6 Asian 30 5.7 2 11.1 6.7 1 50.0 3.3 Black 20 3.8 1 5.6 5.0 1 100.0 5.0 Other 6 1.1 - - - - - - Unknown 1 0.2 - - - - - -

Age group

0-17 20 3.8 2 11.1 10.0 - - - 18-29 45 8.6 1 5.6 2.2 - - - 30-39 65 12.4 4 22.2 6.2 - - - 40-49 70 13.4 3 16.7 4.3 1 33.3 1.4 50-59 177 33.8 6 33.3 3.4 2 33.3 1.1 60-69 146 27.9 2 11.1 1.4 2 100.0 1.4 >70 1 0.2 - - - - - -

Organ Lung 524 100.0 18 100.0 3.4 5 27.8 1.0

NHS Region


85 16.2 4 22.2 4.7 1 25.0 1.2

North West 58 11.1 2 11.1 3.4 - - - Midlands 95 18.1 4 22.2 4.2 2 50.0 2.1 East of England

40 7.6 1 5.6 2.5 - - -

London 56 10.7 3 16.7 5.4 2 66.7 3.6 South East 57 10.9 2 11.1 3.5 - - - South West 42 8.0 1 5.6 2.4 - - - Northern Ireland

26 5.0 - - - - - -

Scotland 41 7.8 1 5.6 2.4 - - - Wales 24 4.6 - - - - - -

- 33 -

Prepared by: Statistics and Clinical Studies, NHS Blood and Transplant Miss Lisa Mumford

In collaboration with: Rommel Ravanan Chris Callaghan

WEEKLY REPORT ON SARS-CoV-2 POSITIVE PATIENTS ......2021/04/09 · • 911 of the 9,932 (9.2%)...

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Transcript of WEEKLY REPORT ON SARS-CoV-2 POSITIVE PATIENTS ......2021/04/09 · • 911 of the 9,932 (9.2%)...