HS-140: Pharmacology Week 8: Urinary System Disorders and Calculating Doses.
Week 8 seminar Urinary System Disorders and Calculating ‘Desired-Doses’ (chapter-28 and...
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Transcript of Week 8 seminar Urinary System Disorders and Calculating ‘Desired-Doses’ (chapter-28 and...
![Page 1: Week 8 seminar Urinary System Disorders and Calculating ‘Desired-Doses’ (chapter-28 and chapter-9)](https://reader036.fdocuments.us/reader036/viewer/2022062515/56649cd75503460f9499fa6c/html5/thumbnails/1.jpg)
Week 8 seminarWeek 8 seminar
Urinary System Disorders
and
Calculating ‘Desired-Doses’
(chapter-28 and chapter-9)
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The Urinary SystemThe Urinary System
Made up of Organs which form & excrete urine
(see Fig.28-1 on pg 585)(2) Kidneys(2) Ureters Bladder Urethra
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Common symptoms Common symptoms of of Urinary System DisordersUrinary System DisordersAnorexia, Nausea, VomitingFatigue, Lethargy, MalaiseDysuria, urgency, frequency,
hematuriaPain in lower-back (kidney area),
flank (sides)Fever, disorientation
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Common Side-effects of Rx’s Common Side-effects of Rx’s for Urinary System Disordersfor Urinary System Disorders
Drying of secretionsDrowsiness, dizziness, sedationRash, hives, ‘urticaria’GI effects (nausea, vomiting, diarrhea)HeadacheDiscoloration of urine
(not always related to a disorder, may be a normal side effect of medication, see Table 28-1, p.585)
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Urinary System DRUG Urinary System DRUG therapytherapySee Chart @ top of page-584 in
Textbook
◦Diuretics ◦Anti-infective◦Urinary Tract Antiseptics◦Urinary Tract Antispasmodics◦Medications for overactive bladder◦Medications for enuresis
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DIURETICSDIURETICSIncreases diuresis (loss of water in
the body)Used with cardiovascular meds to
decrease load on the heart and decease BP
Decreases edema Also causes loss of sodium,
potassium and chlorides (next slide)
Categorized by site of action:◦Thiazides ◦Loop diuretics◦Osmotics
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Electrolyte Imbalance Electrolyte Imbalance EffectsEffectsElectrolyte level symptoms
SODIUM high Edema, thirst, high temp, flushing
low Stomach-cramps, vomiting, diarrhea
POTASSIUM high Abdominal-distension, diarrhea
low Paralysis, weakness, muscle function
CALCIUM high Anorexia, nausea, coma, weakness
low Muscle-cramp/twitching, numbness/tingling of fingers, toes, lips
MAGNESIUM high Flushing, sweating, low temp, cardiac depression
low Abnormal heart rhythms, neurotoxicity
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Urinary Tract Infections Urinary Tract Infections (UTI)(UTI)
Most common bacterial infection in the U.S.
10 – 20% of females have a UTI during lifetime
E.Coli causes ~90% of all cultured UTI’sUpper UTI (kidneys/ureters) -
symptoms include> *lower-back/flank pain *fever *headache *nausea/vomiting
Lower UTI (bladder/urethra) - symptoms include> *frequency *urgency *dysuria *hematuria *oliguria *incontinence
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Some causes of UTI’s Some causes of UTI’s Anything that results in urine being
‘held’ in the bladder (more common in females …sorry ladies!)
If you gotta go … you BETTER go!Dietary factors – certain foods (see
Box 28-1 p587)
Enlarged Prostate (males) – constricts the urethra, causing urine to be ‘retained’ in the bladder
Female ‘Plumbing’ – due to the short length of urethra, and the proximity of the urethra, vagina, and the anus
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UTIUTI - Drug Therapy - Drug TherapyAntibacterials (sulfa-drugs,
trimethoprim) kills bacteria in the urine and systemically
Antiseptics (Macrobid, methenamine) antibiotic activity ONLY in the urine !
Analgesics (Pyridium, AZO-standard otc)
by topical and local anesthesia on the lining of the urinary-tract
--- Study --- Table 28-3 on page 589
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UTIUTI – RX Patient – RX Patient EducationEducation
Sulfonamides (sulfa-drugs) – take on empty-stomach with a full glass of water – DRUGS OF CHOICE FOR TX OF UTI
Drink plenty of water throughout the day (eight to ten 8-oz glasses if on a sulfa-drug)
If taking sulfa-drug, avoid prolonged exposure to sunlight, unless using a good sunscreen !
Complete entire course of UTI drug treatment … even if symptoms improve !!!
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UTIUTI – RX Patient Education – RX Patient Education ((Cont.)Cont.)
Pyridium (phenazopyridine) – changes urine color to orange-red color! May stain clothing
Cranberry juice, Vit-C, prunes make urine more acidic, making antiseptics more effective
Carbonated drinks, citrus fruits make urine less acidic, making antiseptics less effective !
FEVER after starting the drugs may be a sign of a drug-reaction, not a UTI-symptom
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Small, spastic-like bladder (‘tiny-tank’) that empties automatically when filled to a certain point
Tofranil (imipramine) – anti-depressant
DDAVP (desmopressin) – an anti-diuretic that actually increases the reabsorption of water -----available as a Nasal-spray, or tablet
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Time forTime for
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Calculating Doses Calculating Doses (nonparenteral) (nonparenteral)
the main 3 calculation methods
--- Ratio-and-Proportion method
--- Formula-Method --- Dimensional-analysis
Choose the ONE method that you’re most comfortable with …
… and stick with it !
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Why go with ONE Why go with ONE method ?method ?
…you will become very familiar with your ‘chosen’ method
… this will reduce the chance of medication errors that may occur from switching between calculation methods !
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Basic Rules for Confident Basic Rules for Confident CalculatingCalculating
Always check UNIT’s (numerator/denominator)
Always work the problem ON PAPER, even the math seems EASY
Check and RE-CHECK all Decimals, Fractions
LOOK at the RESULT! …does it look reasonable, does it make sense?
Take ONE LAST LOOK to make sure you calculated dose in the correct units
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Box 9-1Box 9-1(p.166) (p.166) Dosage-Dosage-formsformsKnow which types of dosage-forms
can be divided, halved, altered Scored tablets – okay to breakOral – syrups and liquids – okay to alter
Timed-release (sustained, delayed) – DO NOT BREAK or ALTER THESE ! … this can significantly change the rate of the drug’s dissolution (dissolving) and its absorption
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““labeling” the parts of the labeling” the parts of the problemproblem
“DA or A” = dose-available, what is ‘on-hand’
“DO or O” = dose-ordered, what you ‘want’
“DF or V” = dosage-form or vehicle, of the ‘on-hand’
“DG or X” = dose-to-give, this is the unknown-amount of the on-hand drug that we are calculating … this is the ‘X’ that we are solving for.
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Ratio and Proportion Ratio and Proportion can be written with : or /can be written with : or /
Units of measurement must match … numerator : denominator or
numerator / denominatorRatio examples:
60-minutes : 1-hour or
60-minutes / 1-hourProportion examples:
60min : 1hr = 120min : 2hr or
60min / 1hr = 120min / 2hrLet’s try one!: how many minutes in 2.5
hours ?
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Ratio and ProportionRatio and Proportion
How many minutes in 2.5 hours ?1. we are looking for x min / 2.5 hours 2. we know that 60 min / 1 hour 3. so set-up the problem as
60min / 1 hr = X min / 2.5hr 4. now multiply (means x extremes or cross-multiply)
X x 1 = 2.5 x 60 X = 150 minutes
5.150 minutes … our final answer 6. To check your answer: replace x with your answer
in the original set up and multiply. If both sides of the equation match, you are correct
60min / 1 hr = 150 min / 2.5hr 150 min x 1 = 60 x 2.5
150 = 150
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Your Turn:Your Turn:
How many teaspoons in 5 tablespoons?
3 tsp : 1 tbsp3 tsp : 1 tbsp = X tsp : 5 tbsp3 x 5 = 1 x X 15 = X
Check answer: 3 x 5 = 15 x 1 15 = 15
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Formula MethodFormula MethodO / A x V = XO / A x V = X
“DA or A” = dose-available, what is ‘on-hand’ “DO or O” = dose-ordered, what you ‘want’“DF or V” = dosage-form (vehicle), of the
‘on-hand’“DG or X” = dose-given, this is the unknown-
amount of the on-hand drug that we are calculating
Always check that the strengths of the drug-ordered (O) and the drug-available (A) are in the same-unit-of-measure!
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Formula MethodFormula Method cont. cont.Look at page-171
Example #3, then Example #4
Ask yourself … (also, page-171) --what the Dr. ordered (O)? --what strength is available (A)? --what is the unit of measure (V)? --how much do we need to give (X)?
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Let’s Do an ExampleLet’s Do an Example
Physician Ordered: warfarin 20 mg po daily
On hand: warfarin 5 mg tabs
How many tabs will you give daily?
O/A x V = x20 mg / 5 mg x 1 tab = x 4 x 1 tab = x
4 tabs = x
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Try one in liquid form….Try one in liquid form….Dr Smith orders 2 mg of Valium IV to a patient
with seizure activity. You have a 5 mL vial that contains 10 mgs of Valium. (10mg/5mL). How many mLs are you going to draw up?
Formula Method: Ratio/Proportion Method2 mg / 10 mg x 5 mL = X 10 mg : 5 mL = 2 mg : X
mL0.2 x 5 mL = X 10 x X = 5 x
2 1 mL = X 10 X = 10
X = 1 mLCheck Answer:2 mg / 10 mg x 5 mL = 1 mL 10 mg : 5 mL = 2 mg : 1 mL0.2 x 5 mL = 1 mL 10 x 1 = 5 x 2 1 mL = 1 mL 10 = 10
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Dimensional AnalysisDimensional AnalysisDoes not require conversion between
measurement systems firstX always goes on the left side of the =the ‘factors’ go on the right side of the
=◦the first factor is always what was ordered
write the factors so that all “units” can be cancelled except for the one you want your answer to have
X = ordered x available x conversion factor (if needed)
1
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Example using DA:Example using DA:Dr Smith orders 2 mg of Valium IV to a patient with
seizure activity. You have a 5 mL vial that contains 10 mgs of Valium. (10mg/5mL). How many mLs are you going to draw up?
X = 2 mg x 5 mL 1 10 mg
X = 2 x 5 mL 10
X = 10 mL 10
X = 1 mL
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1 More Dimensional Analysis 1 More Dimensional Analysis (with a conversion)(with a conversion)
Dr Jones ordered Levaquin 1g po q 12 h; you have 500 mg tabs. How many tabs will you give daily?
X = 1 g x 1 tab x 1000 mg 1 500 mg 1 g
X = 1 x 1 tab x 1000 500 x 1
X = 1000 500X = 2 tabs
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Converting Grains (gr) to Milligrams Converting Grains (gr) to Milligrams (mg)(mg)
Grains is written totally different than other measurements: the amount is written AFTER the unit and written in Roman Numerals not standard numbers
Examples:
gr i = 1 grain
gr ii = 2 grains
gr v = 5 grains
gr ss = ½ grain (or 0.5 grain)
gr ¼ = ¼ grain (or 0.25 grain)
To convert grains to milligrams use the conversion of
1 gr = 60 mg
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Convert the following gr to Convert the following gr to mgmg
gr v = _________ mg
gr ss = _________ mg
gr ¼ = _________ mg
gr iss = ________ mg
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Answers:Answers:gr v = 300 mg (1 gr : 60 mg = 5 gr : X mg)
1 x X = 60 x 5 X = 300
gr ss = 30 mg (1 gr : 60 mg = 0.5 gr : X mg)
1 x X = 60 x 0.5 X = 30
gr ¼ = 15 mg (1 gr : 60 mg = 0.25 gr : X mg)
1 x X = 60 x 0.25 X = 15
gr iss = 90 mg (1 gr : 60 mg = 1.5 gr : X mg)
(i=1 and ss=0.5) 1 x X = 60 x 1.5 X = 90
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QUESTIONSQUESTIONS
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