Web viewThe role of tantalum nanoparticles in bone regeneration involves the BMP2/Smad4/Runx2...
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The role of tantalum nanoparticles in bone regeneration involves the BMP2/Smad4/Runx2 signaling pathway Guilan Zhang 1,5 , Wenjing Liu 2 , Ruolan Wang 1 , Yanli Zhang 2 , Liangjiao Chen 3 , Aijie Chen 2 , Haiyun Luo 4 , Hui Zhong 1 , Longquan Shao 1,5 1 Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China 2 Department of Prosthodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China 3 Department of Orthodontics, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510150, China 4 Department of Endodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China 5 Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Guangzhou 510515, China Corresponding author: Longquan Shao Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Guangzhou 510515, China Corresponding author Tel.: +86(0)20 15989283921 (L.Shao)
Transcript of Web viewThe role of tantalum nanoparticles in bone regeneration involves the BMP2/Smad4/Runx2...
The role of tantalum nanoparticles in bone regeneration involves the
BMP2/Smad4/Runx2 signaling pathway
Guilan Zhang1,5, Wenjing Liu2, Ruolan Wang1, Yanli Zhang2, Liangjiao Chen3, Aijie
Chen2, Haiyun Luo4, Hui Zhong1, Longquan Shao1,5
1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou
510515, China
2Department of Prosthodontics, Stomatological Hospital, Southern Medical University,
Guangzhou 510280, China
3Department of Orthodontics, Stomatology Hospital of Guangzhou Medical University,
Guangzhou 510150, China
4Department of Endodontics, Stomatological Hospital, Southern Medical University,
Guangzhou 510280, China
5 Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering
Guangzhou 510515, China
Corresponding author: Longquan Shao
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515,
China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue
Engineering Guangzhou 510515, China
Corresponding author Tel.: +86(0)20 15989283921 (L.Shao)
Corresponding author E-mail addresses: [email protected] (L.Shao)
Table S1
Osteogenesis-related genes and primers
Genes Forward primer Reverse primer
ALP TCCTGACCAAAAACCTCAAAGG TGCTTCATGCAGAGCCTGC
BMP2 CGGACTGCGGTCTCCTAA GGAAGCAGCAACGCTAGAAG
OPN AGTACGTCAAGCAGGAGTGCAA CCAGCTTGCACCACTCCAA
Runx2 CCACCACTCACTACCACACG TCAGCGTCAACACCATCATT
Smad4 GCAGCTCTTGGGTTTGGGTC GGCAGCAAACCTACTGATCC
GAPD
H
CAACTACATTCAACGGGAAG TTTGATGTTAGTGGGGTCTCG
Figure S1 The mandible following described surgical procedures: (A) Mandible
defects (5 mm in diameter, 1 mm in depth). (B) Bone defect filling material (HA,
HA+Ta). (C) Suture muscle and skin in bone defect area. (D) Mandible specimen (8
and 12 weeks)
