evolvingbook.com · Web viewSánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I,...

2340
<?xml version='1.0' encoding='utf-8'?> <graphml xmlns="http://graphml.graphdrawing.org/xmlns" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://graphml.graphdrawing.org/xmlns http://graphml.graphdrawing.org/xmlns/1.0/graphml.xsd"><key attr.name="edge_type" attr.type="string" for="edge" id="d16"/> <key attr.name="issn" attr.type="string" for="node" id="d15"/> <key attr.name="essn" attr.type="string" for="node" id="d14"/> <key attr.name="match" attr.type="string" for="node" id="d13"/> <key attr.name="citedOrder" attr.type="long" for="node" id="d12"/> <key attr.name="citedByCount" attr.type="long" for="node" id="d11"/> <key attr.name="pageInfo" attr.type="string" for="node" id="d10"/> <key attr.name="issue" attr.type="string" for="node" id="d9"/> <key attr.name="volume" attr.type="string" for="node" id="d8"/> <key attr.name="pubYear" attr.type="long" for="node" id="d7"/> <key attr.name="journalAbbreviation" attr.type="string" for="node" id="d6"/> <key attr.name="authorString" attr.type="string" for="node" id="d5"/> <key attr.name="title" attr.type="string" for="node" id="d4"/> <key attr.name="citationType" attr.type="string" for="node" id="d3"/> <key attr.name="source" attr.type="string" for="node" id="d2"/> <key attr.name="nodeType" attr.type="string" for="node" id="d1"/> <key attr.name="id" attr.type="string" for="node" id="d0"/> <graph edgedefault="directed"><node id="16904174"> <data key="d0">16904174</data> </node> <node id="27346641"> <data key="d1">refs</data> <data key="d0">27346641</data> <data key="d2">MED</data> <data key="d3">review; journal article; </data> <data key="d4">The molecular hallmarks of epigenetic control.</data>

Transcript of evolvingbook.com · Web viewSánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I,...

<?xml version='1.0' encoding='utf-8'?>

16904174

refs

27346641

MED

review; journal article;

The molecular hallmarks of epigenetic control.

Allis CD, Jenuwein T.

Nat Rev Genet

2016

17

8

487-500

140

refs

26911908

MED

research support, non-u.s. gov't; review; journal article;

Organoids as an in vitro model of human development and disease.

Fatehullah A, Tan SH, Barker N.

Nat Cell Biol

2016

18

3

246-254

134

refs

26646318

MED

research support, non-u.s. gov't; review-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.

Du X, Zhou J, Shi J, Xu B.

Chem Rev

2015

115

24

13165-13307

158

refs

26437589

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression.

Ye X, Weinberg RA.

Trends Cell Biol

2015

25

11

675-686

188

refs

26005811

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.

Paşca AM, Sloan SA, Clarke LE, Tian Y, Makinson CD, Huber N, Kim CH, Park JY, O'Rourke NA, Nguyen KD, Smith SJ, Huguenard JR, Geschwind DH, Barres BA, Paşca SP.

Nat Methods

2015

12

7

671-678

141

refs

25892221

MED

research-article; journal article; research support, n.i.h., extramural;

Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming.

Soufi A, Garcia MF, Jaroszewicz A, Osman N, Pellegrini M, Zaret KS.

Cell

2015

161

3

555-568

107

refs

25642960

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.

Mateos-Gomez PA, Gong F, Nair N, Miller KM, Lazzerini-Denchi E, Sfeir A.

Nature

2015

518

7538

254-257

114

refs

25467564

MED

review; journal article;

The war against heart failure: the Lancet lecture.

Braunwald E.

Lancet

2015

385

9970

812-824

126

refs

25307933

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A protein-tagging system for signal amplification in gene expression and fluorescence imaging.

Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD.

Cell

2014

159

3

635-646

213

refs

25307932

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS.

Cell

2014

159

3

647-661

406

refs

25303535

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Generation of functional human pancreatic β cells in vitro.

Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA.

Cell

2014

159

2

428-439

386

refs

25233993

MED

review; journal article;

mRNA-based therapeutics--developing a new class of drugs.

Sahin U, Karikó K, Türeci Ö.

Nat Rev Drug Discov

2014

13

10

759-780

118

refs

25126793

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

CellNet: network biology applied to stem cell engineering.

Cahan P, Li H, Morris SA, Lummertz da Rocha E, Daley GQ, Collins JJ.

Cell

2014

158

4

903-915

142

refs

25100529

MED

research-article; review; journal article;

Hematopoietic stem cell niche maintenance during homeostasis and regeneration.

Mendelson A, Frenette PS.

Nat Med

2014

20

8

833-846

174

refs

24825474

MED

review-article; review; journal article; research support, n.i.h., extramural;

The Hippo signaling pathway in stem cell biology and cancer.

Mo JS, Park HW, Guan KL.

EMBO Rep

2014

15

6

642-656

127

refs

24726434

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.

Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE.

Cell

2014

157

3

580-594

209

refs

24529372

MED

research support, non-u.s. gov't; journal article;

Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation.

Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y.

Cell

2014

156

4

663-677

123

refs

24441470

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape.

Sherwood RI, Hashimoto T, O'Donnell CW, Lewis S, Barkal AA, van Hoff JP, Karun V, Jaakkola T, Gifford DK.

Nat Biotechnol

2014

32

2

171-178

120

refs

24476887

MED

retracted publication; research support, non-u.s. gov't; journal article;

Stimulus-triggered fate conversion of somatic cells into pluripotency.

Obokata H, Wakayama T, Sasai Y, Kojima K, Vacanti MP, Niwa H, Yamato M, Vacanti CA.

Nature

2014

505

7485

641-647

101

refs

24360883

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.

Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G.

Cell Stem Cell

2014

14

2

188-202

152

refs

24290359

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.

Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA.

Cell

2013

155

6

1351-1364

130

refs

24269804

MED

research support, non-u.s. gov't; review; journal article;

From basics to clinical: a comprehensive review on spinal cord injury.

Silva NA, Sousa N, Reis RL, Salgado AJ.

Prog Neurobiol

2014

114

25-57

122

refs

24141451

MED

research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Biophysical regulation of epigenetic state and cell reprogramming.

Downing TL, Soto J, Morez C, Houssin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S.

Nat Mater

2013

12

12

1154-1162

116

refs

24183012

MED

review; journal article;

Neural stem cells: generating and regenerating the brain.

Gage FH, Temple S.

Neuron

2013

80

3

588-601

140

refs

24153302

MED

research support, non-u.s. gov't; review; journal article;

The nexus of chromatin regulation and intermediary metabolism.

Gut P, Verdin E.

Nature

2013

502

7472

489-498

133

refs

24153299

MED

research-article; review; journal article;

Chromatin dynamics during cellular reprogramming.

Apostolou E, Hochedlinger K.

Nature

2013

502

7472

462-471

142

refs

24056302

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

In vivo reprogramming of astrocytes to neuroblasts in the adult brain.

Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R, Zhang CL.

Nat Cell Biol

2013

15

10

1164-1175

139

refs

24048479

MED

research support, non-u.s. gov't; journal article;

Deterministic direct reprogramming of somatic cells to pluripotency.

Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH.

Nature

2013

502

7469

65-70

231

refs

24025773

MED

research support, non-u.s. gov't; journal article;

Reprogramming in vivo produces teratomas and iPS cells with totipotency features.

Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M.

Nature

2013

502

7471

340-345

116

refs

23995067

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.

Flavahan WA, Wu Q, Hitomi M, Rahim N, Kim Y, Sloan AE, Weil RJ, Nakano I, Sarkaria JN, Stringer BW, Day BW, Li M, Lathia JD, Rich JN, Hjelmeland AB.

Nat Neurosci

2013

16

10

1373-1382

109

refs

23995685

MED

research support, non-u.s. gov't; research-article; journal article;

Cerebral organoids model human brain development and microcephaly.

Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA.

Nature

2013

501

7467

373-379

652

refs

23917223

MED

research-article; journal article;

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells.

Herreros-Villanueva M, Zhang JS, Koenig A, Abel EV, Smyrk TC, Bamlet WR, de Narvajas AA, Gomez TS, Simeone DM, Bujanda L, Billadeau DD.

Oncogenesis

2013

2

e61

105

refs

23989721

MED

research-article; review; journal article; research support, n.i.h., extramural;

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions.

Sanganalmath SK, Bolli R.

Circ Res

2013

113

6

810-834

192

refs

23953112

MED

research support, non-u.s. gov't; journal article;

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Yan J, Enge M, Whitington T, Dave K, Liu J, Sur I, Schmierer B, Jolma A, Kivioja T, Taipale M, Taipale J.

Cell

2013

154

4

801-813

122

refs

23868920

MED

research support, non-u.s. gov't; journal article;

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.

Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H.

Science

2013

341

6146

651-654

432

refs

23850316

MED

research support, non-u.s. gov't; review; journal article;

Mitochondrial regulation in pluripotent stem cells.

Xu X, Duan S, Yi F, Ocampo A, Liu GH, Izpisua Belmonte JC.

Cell Metab

2013

18

3

325-332

114

refs

23839576

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.

Xin M, Olson EN, Bassel-Duby R.

Nat Rev Mol Cell Biol

2013

14

8

529-541

133

refs

23810552

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.

Liu L, Cheung TH, Charville GW, Hurgo BM, Leavitt T, Shih J, Brunet A, Rando TA.

Cell Rep

2013

4

1

189-204

133

refs

23788621

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

A double take on bivalent promoters.

Voigt P, Tee WW, Reinberg D.

Genes Dev

2013

27

12

1318-1338

250

refs

23764001

MED

research support, non-u.s. gov't; journal article;

Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming.

Tiwari N, Tiwari VK, Waldmeier L, Balwierz PJ, Arnold P, Pachkov M, Meyer-Schaller N, Schübeler D, van Nimwegen E, Christofori G.

Cancer Cell

2013

23

6

768-783

130

refs

23746978

MED

research-article; journal article; research support, n.i.h., extramural;

Cardiac stem cell therapy and the promise of heart regeneration.

Garbern JC, Lee RT.

Cell Stem Cell

2013

12

6

689-698

136

refs

23698584

MED

research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription.

Pastor WA, Aravind L, Rao A.

Nat Rev Mol Cell Biol

2013

14

6

341-356

286

refs

23681063

MED

research support, non-u.s. gov't; research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Mechanisms and models of somatic cell reprogramming.

Buganim Y, Faddah DA, Jaenisch R.

Nat Rev Genet

2013

14

6

427-439

167

refs

23683578

MED

research-article; journal article; research support, n.i.h., extramural;

Human embryonic stem cells derived by somatic cell nuclear transfer.

Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S.

Cell

2013

153

6

1228-1238

255

refs

23706735

MED

research support, non-u.s. gov't; research-article; journal article;

Induction of pluripotency in mouse somatic cells with lineage specifiers.

Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H.

Cell

2013

153

5

963-975

133

refs

23635789

MED

research support, non-u.s. gov't; review-article; review; journal article;

Cancer stem cells in the development of liver cancer.

Yamashita T, Wang XW.

J Clin Invest

2013

123

5

1911-1918

141

refs

23616747

MED

review-article; journal article;

Origin and differentiation of microglia.

Ginhoux F, Lim S, Hoeffel G, Low D, Huber T.

Front Cell Neurosci

2013

7

45

142

refs

23584610

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Generation of oligodendroglial cells by direct lineage conversion.

Yang N, Zuchero JB, Ahlenius H, Marro S, Ng YH, Vierbuchen T, Hawkins JS, Geissler R, Barres BA, Wernig M.

Nat Biotechnol

2013

31

5

434-439

115

refs

23582322

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.

Cell

2013

153

2

307-319

798

refs

23530235

MED

research support, non-u.s. gov't; research-article; journal article;

Generation of induced neurons via direct conversion in vivo.

Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Björklund A, Grealish S, Parmar M.

Proc Natl Acad Sci U S A

2013

110

17

7038-7043

122

refs

23524953

MED

research support, non-u.s. gov't; research-article; journal article;

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.

Moignard V, Macaulay IC, Swiers G, Buettner F, Schütte J, Calero-Nieto FJ, Kinston S, Joshi A, Hannah R, Theis FJ, Jacobsen SE, de Bruijn MF, Göttgens B.

Nat Cell Biol

2013

15

4

363-372

126

refs

23520387

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Robust cellular reprogramming occurs spontaneously during liver regeneration.

Yanger K, Zong Y, Maggs LR, Shapira SN, Maddipati R, Aiello NM, Thung SN, Wells RG, Greenbaum LE, Stanger BZ.

Genes Dev

2013

27

7

719-724

148

refs

23499384

MED

research support, non-u.s. gov't; journal article;

Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming.

Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, Gao S.

Cell Stem Cell

2013

12

4

453-469

130

refs

23463313

MED

research support, non-u.s. gov't; review; journal article;

Epigenetic programming and reprogramming during development.

Cantone I, Fisher AG.

Nat Struct Mol Biol

2013

20

3

282-289

142

refs

23498940

MED

research support, non-u.s. gov't; research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Epigenetics of reprogramming to induced pluripotency.

Papp B, Plath K.

Cell

2013

152

6

1324-1343

124

refs

23498934

MED

research-article; review; journal article; research support, n.i.h., extramural;

Transcriptional regulation and its misregulation in disease.

Lee TI, Young RA.

Cell

2013

152

6

1237-1251

225

refs

23472874

MED

research support, non-u.s. gov't; journal article;

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.

Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T, Maisel M, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler HR, Sterneckert J.

Cell Stem Cell

2013

12

3

354-367

165

refs

23193063

MED

research support, non-u.s. gov't; journal article;

An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells.

Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S.

Stem Cells

2013

31

3

458-466

152

refs

23434068

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs.

Lamouille S, Subramanyam D, Blelloch R, Derynck R.

Curr Opin Cell Biol

2013

25

2

200-207

120

refs

23395962

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J.

Nature

2013

495

7441

370-374

150

refs

23355455

MED

research support, non-u.s. gov't; review; journal article;

Gene therapy clinical trials worldwide to 2012 - an update.

Ginn SL, Alexander IE, Edelstein ML, Abedi MR, Wixon J.

J Gene Med

2013

15

2

65-77

278

refs

23302801

MED

research support, non-u.s. gov't; journal article;

Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells.

Araki R, Uda M, Hoki Y, Sunayama M, Nakamura M, Ando S, Sugiura M, Ideno H, Shimada A, Nifuji A, Abe M.

Nature

2013

494

7435

100-104

215

refs

23340407

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.

Mae SI, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K.

Nat Commun

2013

4

1367

100

refs

23303905

MED

review-article; review; journal article;

Satellite cells and the muscle stem cell niche.

Yin H, Price F, Rudnicki MA.

Physiol Rev

2013

93

1

23-67

337

refs

23207911

MED

research support, non-u.s. gov't; review; journal article;

Next-generation proteomics: towards an integrative view of proteome dynamics.

Altelaar AF, Munoz J, Heck AJ.

Nat Rev Genet

2013

14

1

35-48

199

refs

23202127

MED

research support, non-u.s. gov't; journal article;

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.

Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, Liang H, Chen Y, Chen J, Wu Y, Guo L, Zhu J, Zhao X, Peng T, Zhang Y, Chen S, Li X, Li D, Wang T, Pei D.

Nat Genet

2013

45

1

34-42

181

refs

23260147

MED

research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A molecular roadmap of reprogramming somatic cells into iPS cells.

Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K.

Cell

2012

151

7

1617-1632

333

refs

23159369

MED

research-article; journal article; research support, n.i.h., extramural;

Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome.

Soufi A, Donahue G, Zaret KS.

Cell

2012

151

5

994-1004

279

refs

23138349

MED

research support, non-u.s. gov't; journal article;

Generation of human induced pluripotent stem cells from urine samples.

Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA.

Nat Protoc

2012

7

12

2080-2089

133

refs

23122287

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Metabolic plasticity in stem cell homeostasis and differentiation.

Folmes CD, Dzeja PP, Nelson TJ, Terzic A.

Cell Stem Cell

2012

11

5

596-606

191

refs

23034453

MED

research support, non-u.s. gov't; review; journal article;

Induced pluripotent stem cells: the new patient?

Bellin M, Marchetto MC, Gage FH, Mummery CL.

Nat Rev Mol Cell Biol

2012

13

11

713-726

175

refs

23101625

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Activation of innate immunity is required for efficient nuclear reprogramming.

Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski ES, Pera RR, Yakubov E, Cooke JP.

Cell

2012

151

3

547-558

130

refs

23040477

MED

research support, non-u.s. gov't; research-article; journal article;

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells.

Festuccia N, Osorno R, Halbritter F, Karwacki-Neisius V, Navarro P, Colby D, Wong F, Yates A, Tomlinson SR, Chambers I.

Cell Stem Cell

2012

11

4

477-490

150

refs

22996603

MED

review; journal article; research support, n.i.h., extramural;

Paths to stemness: building the ultimate antitumour T cell.

Gattinoni L, Klebanoff CA, Restifo NP.

Nat Rev Cancer

2012

12

10

671-684

150

refs

22992590

MED

research-article; review; journal article; research support, n.i.h., extramural;

TGFβ signalling in context.

Massagué J.

Nat Rev Mol Cell Biol

2012

13

10

616-630

858

refs

22976355

MED

research support, non-u.s. gov't; journal article;

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.

Shi Y, Kirwan P, Livesey FJ.

Nat Protoc

2012

7

10

1836-1846

155

refs

22959076

MED

research-article; journal article; research support, n.i.h., extramural;

Circuitry and dynamics of human transcription factor regulatory networks.

Neph S, Stergachis AB, Reynolds A, Sandstrom R, Borenstein E, Stamatoyannopoulos JA.

Cell

2012

150

6

1274-1286

162

refs

22943504

MED

review-article; journal article;

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease.

Fan D, Takawale A, Lee J, Kassiri Z.

Fibrogenesis Tissue Repair

2012

5

1

15

150

refs

22941189

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.

Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S.

Nat Genet

2012

44

10

1111-1116

313

refs

22980981

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase.

Buganim Y, Faddah DA, Cheng AW, Itskovich E, Markoulaki S, Ganz K, Klemm SL, van Oudenaarden A, Jaenisch R.

Cell

2012

150

6

1209-1222

417

refs

22972301

MED

research support, non-u.s. gov't; research-article; journal article;

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.

Vilchez D, Boyer L, Morantte I, Lutz M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A.

Nature

2012

489

7415

304-308

122

refs

22902501

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.

Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, Guarnieri P, Bhagat G, Vanti WB, Shih A, Levine RL, Nik S, Chen EI, Abeliovich A.

Nature

2012

488

7413

652-655

169

refs

22869594

MED

research support, non-u.s. gov't; review-article; review; journal article;

The evolving concept of cancer and metastasis stem cells.

Baccelli I, Trumpp A.

J Cell Biol

2012

198

3

281-293

137

refs

22801502

MED

research support, non-u.s. gov't; journal article;

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, Krupalnik V, Zerbib M, Amann-Zalcenstein D, Maza I, Geula S, Viukov S, Holtzman L, Pribluda A, Canaani E, Horn-Saban S, Amit I, Novershtern N, Hanna JH.

Nature

2012

488

7411

409-413

144

refs

22784697

MED

research support, non-u.s. gov't; research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

How does Lin28 let-7 control development and disease?

Thornton JE, Gregory RI.

Trends Cell Biol

2012

22

9

474-482

146

refs

22704655

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Dynamics and memory of heterochromatin in living cells.

Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR.

Cell

2012

149

7

1447-1460

138

refs

22683203

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y.

Cell Stem Cell

2012

11

1

100-109

235

refs

22704507

MED

journal article

Induced pluripotent stem cells: past, present, and future.

Yamanaka S.

Cell Stem Cell

2012

10

6

678-684

250

refs

22660318

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Heart repair by reprogramming non-myocytes with cardiac transcription factors.

Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN.

Nature

2012

485

7400

599-604

432

refs

22710160

MED

research support, non-u.s. gov't; review; journal article;

BMP signaling in vascular diseases.

Cai J, Pardali E, Sánchez-Duffhues G, ten Dijke P.

FEBS Lett

2012

586

14

1993-2002

101

refs

22560079

MED

research support, non-u.s. gov't; research-article; journal article;

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.

Reynolds N, Latos P, Hynes-Allen A, Loos R, Leaford D, O'Shaughnessy A, Mosaku O, Signolet J, Brennecke P, Kalkan T, Costello I, Humphreys P, Mansfield W, Nakagawa K, Strouboulis J, Behrens A, Bertone P, Hendrich B.

Cell Stem Cell

2012

10

5

583-594

103

refs

22522929

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.

Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D.

Nature

2012

485

7400

593-598

484

refs

22415904

MED

review; journal article;

Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine.

Mizuno H, Tobita M, Uysal AC.

Stem Cells

2012

30

5

804-810

227

refs

22539765

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.

Jayawardena TM, Egemnazarov B, Finch EA, Zhang L, Payne JA, Pandya K, Zhang Z, Rosenberg P, Mirotsou M, Dzau VJ.

Circ Res

2012

110

11

1465-1473

245

refs

22498752

MED

research support, non-u.s. gov't; review; journal article;

Epigenetic protein families: a new frontier for drug discovery.

Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M.

Nat Rev Drug Discov

2012

11

5

384-400

427

refs

22484851

MED

research support, non-u.s. gov't; journal article;

Small molecules enable highly efficient neuronal conversion of human fibroblasts.

Ladewig J, Mertens J, Kesavan J, Doerr J, Poppe D, Glaue F, Herms S, Wernet P, Kögler G, Müller FJ, Koch P, Brüstle O.

Nat Methods

2012

9

6

575-578

113

refs

22482508

MED

research support, non-u.s. gov't; journal article;

Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells.

Wang Z, Oron E, Nelson B, Razis S, Ivanova N.

Cell Stem Cell

2012

10

4

440-454

179

refs

22445518

MED

research support, non-u.s. gov't; journal article;

Direct conversion of fibroblasts into stably expandable neural stem cells.

Thier M, Wörsdörfer P, Lakes YB, Gorris R, Herms S, Opitz T, Seiferling D, Quandel T, Hoffmann P, Nöthen MM, Brüstle O, Edenhofer F.

Cell Stem Cell

2012

10

4

473-479

240

refs

22445517

MED

research support, non-u.s. gov't; journal article;

Direct reprogramming of fibroblasts into neural stem cells by defined factors.

Han DW, Tapia N, Hermann A, Hemmer K, Höing S, Araúzo-Bravo MJ, Zaehres H, Wu G, Frank S, Moritz S, Greber B, Yang JH, Lee HT, Schwamborn JC, Storch A, Schöler HR.

Cell Stem Cell

2012

10

4

465-472

240

refs

22407749

MED

research support, non-u.s. gov't; research-article; journal article;

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Caig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A.

EMBO Mol Med

2012

4

5

380-395

180

refs

22406749

MED

research support, non-u.s. gov't; review-article; review; journal article; research support, n.i.h., extramural;

Smooth muscle cell phenotypic switching in atherosclerosis.

Gomez D, Owens GK.

Cardiovasc Res

2012

95

2

156-164

181

refs

22388813

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Chromatin-modifying enzymes as modulators of reprogramming.

Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ.

Nature

2012

483

7391

598-602

267

refs

22387999

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.

Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, Ooi SS, Kim SY, Bestor TH, Shioda T, Park PJ, Hochedlinger K.

Nat Genet

2012

44

4

398-405, S1-2

122

refs

22464322

MED

research-article; review; journal article;

Malignant glioma: lessons from genomics, mouse models, and stem cells.

Chen J, McKay RM, Parada LF.

Cell

2012

149

1

36-47

195

refs

22464321

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

MYC on the path to cancer.

Dang CV.

Cell

2012

149

1

22-35

742

refs

22405797

MED

research support, non-u.s. gov't; review; journal article; research support, n.i.h., extramural;

Engineered whole organs and complex tissues.

Badylak SF, Weiss DJ, Caplan A, Macchiarini P.

Lancet

2012

379

9819

943-952

200

refs

22387025

MED

research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural;

Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells.

Li M, He Y, Dubois W, Wu X, Shi J, Huang J.

Mol Cell

2012

46

1

30-42

113

refs

22385965

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Slug and Sox9 cooperatively determine the mammary stem cell state.

Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA.

Cell

2012

148

5

1015-1028

357

refs

22385658

MED

research-article; journal article; research support, n.i.h., extramural;

Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.

Singh AM, Reynolds D, Cliff T, Ohtsuka S, Mattheyses AL, Sun Y, Menendez L, Kulik M, Dalton S.

Cell Stem Cell

2012

10

3

312-326

149

refs

22389628

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC.

PLoS Biol

2012

10

2

e1001268

105

refs

22340591

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A mouse model of the most aggressive subgroup of human medulloblastoma.

Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF.

Cancer Cell

2012

21

2

168-180

114

refs

22305566

MED

research support, non-u.s. gov't; research-article; journal article;

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.

Brookes E, de Santiago I, Hebenstreit D, Morris KJ, Carroll T, Xie SQ, Stock JK, Heidemann M, Eick D, Nozaki N, Kimura H, Ragoussis J, Teichmann SA, Pombo A.

Cell Stem Cell

2012

10

2

157-170

125

refs

22308465

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells.

Lujan E, Chanda S, Ahlenius H, Südhof TC, Wernig M.

Proc Natl Acad Sci U S A

2012

109

7

2527-2532

215

refs

22286766

MED

research-article; journal article; research support, n.i.h., extramural;

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation.

Kumar SM, Liu S, Lu H, Zhang H, Zhang PJ, Gimotty PA, Guerra M, Guo W, Xu X.

Oncogene

2012

31

47

4898-4911

130

refs

22258608

MED

research support, american recovery and reinvestment act; research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

The promise of induced pluripotent stem cells in research and therapy.

Robinton DA, Daley GQ.

Nature

2012

481

7381

295-305

434

refs

22237392

MED

research support, non-u.s. gov't; review;

Cancer stem cells: an evolving concept.

Nguyen LV, Vanner R, Dirks P, Eaves CJ.

Nat Rev Cancer

2012

12

2

133-143

345

refs

22216957

MED

research support, non-u.s. gov't; review-article; review; journal article;

Clinical application of stem cell therapy in Parkinson's disease.

Politis M, Lindvall O.

BMC Med

2012

10

1

104

refs

23339648

MED

research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Bone tissue engineering: recent advances and challenges.

Amini AR, Laurencin CT, Nukavarapu SP.

Crit Rev Biomed Eng

2012

40

5

363-408

261

refs

23057748

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Cardiac regenerative capacity and mechanisms.

Kikuchi K, Poss KD.

Annu Rev Cell Dev Biol

2012

28

719-741

105

refs

22265401

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.

Rando TA, Chang HY.

Cell

2012

148

1-2

46-57

142

refs

22226352

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming.

Burridge PW, Keller G, Gold JD, Wu JC.

Cell Stem Cell

2012

10

1

16-28

242

refs

22189618

MED

research-article; journal article; research support, n.i.h., extramural;

ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells.

Liu X, Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, Haddad BR, Rhim JS, Dritschilo A, Riegel A, McBride A, Schlegel R.

Am J Pathol

2012

180

2

599-607

233

refs

22136931

MED

research support, non-u.s. gov't; research-article; journal article;

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schmauss G, Schramek D, Schnuetgen F, von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A, Penninger JM.

Cell Stem Cell

2011

9

6

563-574

112

refs

22120178

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.

Paşca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Paşca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE.

Nat Med

2011

17

12

1657-1662

216

refs

22100412

MED

research support, non-u.s. gov't; journal article;

The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.

Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G, Pei D.

Cell Stem Cell

2011

9

6

575-587

174

refs

22064701

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.

Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisua Belmonte JC.

Cell Res

2012

22

1

168-177

188

refs

22056668

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Pioneer transcription factors: establishing competence for gene expression.

Zaret KS, Carroll JS.

Genes Dev

2011

25

21

2227-2241

513

refs

22022567

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ.

PLoS One

2011

6

10

e26203

132

refs

21990348

MED

research support, non-u.s. gov't; research-article; journal article;

Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.

Wang W, Yang J, Liu H, Lu D, Chen X, Zenonos Z, Campos LS, Rad R, Guo G, Zhang S, Bradley A, Liu P.

Proc Natl Acad Sci U S A

2011

108

45

18283-18288

114

refs

22017177

MED

review; journal article;

Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.

Alexander MR, Owens GK.

Annu Rev Physiol

2012

74

13-40

157

refs

22036565

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Master transcription factors determine cell-type-specific responses to TGF-β signaling.

Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA.

Cell

2011

147

3

565-576

256

refs

21997635

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Direct lineage conversions: unnatural but useful?

Vierbuchen T, Wernig M.

Nat Biotechnol

2011

29

10

892-907

123

refs

21982232

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice.

Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K.

Cell Stem Cell

2011

9

4

317-329

252

refs

21952300

MED

research support, non-u.s. gov't; review; journal article; research support, n.i.h., extramural;

Forming functional fat: a growing understanding of adipocyte differentiation.

Cristancho AG, Lazar MA.

Nat Rev Mol Cell Biol

2011

12

11

722-734

422

refs

21949375

MED

research support, non-u.s. gov't; research-article; journal article;

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice.

Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H.

Proc Natl Acad Sci U S A

2011

108

40

16825-16830

179

refs

21944829

MED

research-article; review; journal article; research support, n.i.h., extramural;

Biomimetic nanofibrous scaffolds for bone tissue engineering.

Holzwarth JM, Ma PX.

Biomaterials

2011

32

36

9622-9629

146

refs

21924933

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.

Hodges E, Molaro A, Dos Santos CO, Thekkat P, Song Q, Uren PJ, Park J, Butler J, Rafii S, McCombie WR, Smith AD, Hannon GJ.

Mol Cell

2011

44

1

17-28

140

refs

21924763

MED

research support, non-u.s. gov't; journal article; research support, n.i.h., extramural;

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.

Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ.

Cell

2011

147

1

132-146

150

refs

21908035

MED

research support, non-u.s. gov't; review; journal article;

Thalassaemia.

Higgs DR, Engel JD, Stamatoyannopoulos G.

Lancet

2012

379

9813

373-383

110

refs

21903262

MED

research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid.

Kim IL, Mauck RL, Burdick JA.

Biomaterials

2011

32

34

8771-8782

134

refs

21881606

MED

research support, non-u.s. gov't; review-article; review; journal article;

Roles of the Polycomb group proteins in stem cells and cancer.

Richly H, Aloia L, Di Croce L.

Cell Death Dis

2011

2

e204

127

refs

21852222

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Conversion of mouse and human fibroblasts into functional spinal motor neurons.

Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K.

Cell Stem Cell

2011

9

3

205-218

296

refs

21863007

MED

research support, non-u.s. gov't; research-article; journal article;

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.

Devine MJ, Ryten M, Vodicka P, Thomson AJ, Burdon T, Houlden H, Cavaleri F, Nagano M, Drummond NJ, Taanman JW, Schapira AH, Gwinn K, Hardy J, Lewis PA, Kunath T.

Nat Commun

2011

2

440

167

refs

21860412

MED

research support, non-u.s. gov't; review-article; review; journal article;

DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer.

Lopez-Serra P, Esteller M.

Oncogene

2012

31

13

1609-1622

149

refs

21852138

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.

Liou YC, Zhou XZ, Lu KP.

Trends Biochem Sci

2011

36

10

501-514

152

refs

21820164

MED

research support, non-u.s. gov't; journal article;

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.

Hayashi K, Ohta H, Kurimoto K, Aramaki S, Saitou M.

Cell

2011

146

4

519-532

329

refs

21816272

MED

retracted publication; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons.

Qiang L, Fujita R, Yamashita T, Angulo S, Rhinn H, Rhee D, Doege C, Chau L, Aubry L, Vanti WB, Moreno H, Abeliovich A.

Cell

2011

146

3

359-371

152

refs

21803296

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

Folmes CD, Nelson TJ, Martinez-Fernandez A, Arrell DK, Lindor JZ, Dzeja PP, Ikeda Y, Perez-Terzic C, Terzic A.

Cell Metab

2011

14

2

264-271

329

refs

21417722

MED

research support, non-u.s. gov't; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds.

Badylak SF, Taylor D, Uygun K.

Annu Rev Biomed Eng

2011

13

27-53

293

refs

21804543

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.

Zhang X, Yalcin S, Lee DF, Yeh TY, Lee SM, Su J, Mungamuri SK, Rimmelé P, Kennedy M, Sellers R, Landthaler M, Tuschl T, Chi NW, Lemischka I, Keller G, Ghaffari S.

Nat Cell Biol

2011

13

9

1092-1099

108

refs

21765457

MED

research support, non-u.s. gov't; review; journal article;

Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation.

Wutz A.

Nat Rev Genet

2011

12

8

542-553

148

refs

21729306

MED

research support, non-u.s. gov't; research-article; journal article;

Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells.

Zuccotti M, Merico V, Bellone M, Mulas F, Sacchi L, Rebuzzini P, Prigione A, Redi CA, Bellazzi R, Adjaye J, Garagna S.

BMC Genomics

2011

12

1-13

132

refs

21763607

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

A hitchhiker's guide to mechanobiology.

Eyckmans J, Boudou T, Yu X, Chen CS.

Dev Cell

2011

21

1

35-47

139

refs

21617704

MED

research support, non-u.s. gov't; report; journal article;

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.

Redmer T, Diecke S, Grigoryan T, Quiroga-Negreira A, Birchmeier W, Besser D.

EMBO Rep

2011

12

7

720-726

134

refs

21716291

MED

research support, non-u.s. gov't; journal article;

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.

Sekiya S, Suzuki A.

Nature

2011

475

7356

390-393

332

refs

21706029

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.

Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massagué J.

Nat Med

2011

17

7

867-874

306

refs

21698063

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Energy metabolism in human pluripotent stem cells and their differentiated counterparts.

Varum S, Rodrigues AS, Moura MB, Momcilovic O, Easley CA, Ramalho-Santos J, Van Houten B, Schatten G.

PLoS One

2011

6

6

e20914

241

refs

21673106

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.

Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A.

J Biol Chem

2011

286

32

28097-28110

115

refs

21670502

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Krüppel-like factor 4 regulates macrophage polarization.

Liao X, Sharma N, Kapadia F, Zhou G, Lu Y, Hong H, Paruchuri K, Mahabeleshwar GH, Dalmas E, Venteclef N, Flask CA, Kim J, Doreian BW, Lu KQ, Kaestner KH, Hamik A, Clément K, Jain MK.

J Clin Invest

2011

121

7

2736-2749

198

refs

21654807

MED

research support, non-u.s. gov't; journal article;

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.

Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, Kawamura Y, Mochizuki H, Goshima N, Yamanaka S.

Nature

2011

474

7350

225-229

164

refs

21646515

MED

research support, non-u.s. gov't; research-article; journal article;

Direct conversion of human fibroblasts to dopaminergic neurons.

Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M.

Proc Natl Acad Sci U S A

2011

108

25

10343-10348

313

refs

21663792

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Pluripotency factors in embryonic stem cells regulate differentiation into germ layers.

Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, Ramanathan S.

Cell

2011

145

6

875-889

237

refs

21633173

MED

review-article; review; journal article; research support, n.i.h., extramural;

The three R's of lung health and disease: repair, remodeling, and regeneration.

Beers MF, Morrisey EE.

J Clin Invest

2011

121

6

2065-2073

107

refs

21620789

MED

research support, non-u.s. gov't; journal article;

Reprogramming of mouse and human cells to pluripotency using mature microRNAs.

Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL, Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M.

Cell Stem Cell

2011

8

6

633-638

337

refs

21628563

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype.

Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, Xia S, Trageser D, Guerrero-Cázares H, Eberhart CG, Quiñones-Hinojosa A, Scheffler B, Laterra J.

Proc Natl Acad Sci U S A

2011

108

24

9951-9956

105

refs

21637780

MED

comparative study; research support, non-u.s. gov't; research-article; journal article;

DNA methylation dynamics in human induced pluripotent stem cells over time.

Nishino K, Toyoda M, Yamazaki-Inoue M, Fukawatase Y, Chikazawa E, Sakaguchi H, Akutsu H, Umezawa A.

PLoS Genet

2011

7

5

e1002085

139

refs

21576821

MED

comparative study; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.

Rhee YH, Ko JY, Chang MY, Yi SH, Kim D, Kim CH, Shim JW, Jo AY, Kim BW, Lee H, Lee SH, Suh W, Park CH, Koh HC, Lee YS, Lanza R, Kim KS, Lee SH.

J Clin Invest

2011

121

6

2326-2335

106

refs

21572395

MED

research support, non-u.s. gov't; journal article; research support, n.i.h., extramural;

Immunogenicity of induced pluripotent stem cells.

Zhao T, Zhang ZN, Rong Z, Xu Y.

Nature

2011

474

7350

212-215

569

refs

21593865

MED

research-article; review; journal article; research support, n.i.h., extramural;

Heart regeneration.

Laflamme MA, Murry CE.

Nature

2011

473

7347

326-335

434

refs

21540845

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Harnessing the potential of induced pluripotent stem cells for regenerative medicine.

Wu SM, Hochedlinger K.

Nat Cell Biol

2011

13

5

497-505

229

refs

21559507

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.

Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ.

PLoS One

2011

6

4

e18992

124

refs

21521790

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Direct reprogramming of mouse fibroblasts to neural progenitors.

Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S.

Proc Natl Acad Sci U S A

2011

108

19

7838-7843

278

refs

21512031

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.

Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF.

Science

2011

332

6028

458-461

328

refs

21497756

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.

Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A.

Dev Cell

2011

20

4

419-429

110

refs

21474102

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.

Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE.

Cell Stem Cell

2011

8

4

376-388

565

refs

21458673

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW.

Cell

2011

145

1

145-158

150

refs

21415849

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Progress in understanding reprogramming to the induced pluripotent state.

Plath K, Lowry WE.

Nat Rev Genet

2011

12

4

253-265

133

refs

21451513

MED

research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Profiling metabolites and peptides in single cells.

Rubakhin SS, Romanova EV, Nemes P, Sweedler JV.

Nat Methods

2011

8

4 suppl

S20-9

101

refs

21430656

MED

research support, non-u.s. gov't; review; journal article;

The use of induced pluripotent stem cells in drug development.

Inoue H, Yamanaka S.

Clin Pharmacol Ther

2011

89

5

655-661

100

refs

21454525

MED

research support, non-u.s. gov't; research-article; journal article;

MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition.

Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D.

J Biol Chem

2011

286

19

17359-17364

130

refs

21418664

MED

review-article; journal article;

Risk factors in the development of stem cell therapy.

Herberts CA, Kwa MS, Hermsen HP.

J Transl Med

2011

9

29

105

refs

21411759

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting.

Zou J, Sweeney CL, Chou BK, Choi U, Pan J, Wang H, Dowey SN, Cheng L, Malech HL.

Blood

2011

117

21

5561-5572

134

refs

21390059

MED

research support, non-u.s. gov't; review; journal article;

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

Zöller M.

Nat Rev Cancer

2011

11

4

254-267

369

refs

21390058

MED

research support, non-u.s. gov't; review; journal article;

The tumorigenicity of human embryonic and induced pluripotent stem cells.

Ben-David U, Benvenisty N.

Nat Rev Cancer

2011

11

4

268-277

305

refs

21386864

MED

research support, non-u.s. gov't; review; journal article;

Turning straw into gold: directing cell fate for regenerative medicine.

Cohen DE, Melton D.

Nat Rev Genet

2011

12

4

243-252

110

refs

21378979

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A bioinformatic assay for pluripotency in human cells.

Müller FJ, Schuldt BM, Williams R, Mason D, Altun G, Papapetrou EP, Danner S, Goldmann JE, Herbst A, Schmidt NO, Aldenhoff JB, Laurent LC, Loring JF.

Nat Methods

2011

8

4

315-317

200

refs

21414483

MED

research support, non-u.s. gov't; research-article; review; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Cellular decision making and biological noise: from microbes to mammals.

Balázsi G, van Oudenaarden A, Collins JJ.

Cell

2011

144

6

910-925

319

refs

21368825

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Somatic coding mutations in human induced pluripotent stem cells.

Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisua Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K.

Nature

2011

471

7336

63-67

608

refs

21368824

MED

research support, non-u.s. gov't; journal article;

Copy number variation and selection during reprogramming to pluripotency.

Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, Bazett-Jones DP, Alitalo K, Lahesmaa R, Nagy A, Otonkoski T.

Nature

2011

471

7336

58-62

464

refs

21346783

MED

research support, non-u.s. gov't; review; journal article;

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.

Martínez P, Blasco MA.

Nat Rev Cancer

2011

11

3

161-176

194

refs

21362705

MED

research support, non-u.s. gov't; review-article; review; journal article; research support, n.i.h., extramural;

Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges.

Tongers J, Losordo DW, Landmesser U.

Eur Heart J

2011

32

10

1197-1206

114

refs

21339765

MED

research support, non-u.s. gov't; review; journal article;

Methods for making induced pluripotent stem cells: reprogramming à la carte.

González F, Boué S, Izpisúa Belmonte JC.

Nat Rev Genet

2011

12

4

231-242

196

refs

21289626

MED

research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural;

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.

Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O'Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR.

Nature

2011

471

7336

68-73

751

refs

21316591

MED

research support, non-u.s. gov't; journal article;

Trophectoderm lineage determination in cattle.

Berg DK, Smith CS, Pearton DJ, Wells DN, Broadhurst R, Donnison M, Pfeffer PL.

Dev Cell

2011

20

2

244-255

117

refs

21295276

MED

research support, american recovery and reinvestment act; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.

Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A.

Cell Stem Cell

2011

8

2

200-213

346

refs

21285944

MED

research-article; journal article;

Small RNA-mediated regulation of iPS cell generation.

Li Z, Yang CS, Nakashima K, Rana TM.

EMBO J

2011

30

5

823-834

168

refs

21252997

MED

research support, non-u.s. gov't; review; journal article;

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

Jopling C, Boue S, Izpisua Belmonte JC.

Nat Rev Mol Cell Biol

2011

12

2

79-89

203

refs

21278734

MED

research support, non-u.s. gov't; journal article; research support, n.i.h., extramural;

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy.

Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, Chen J, Ding S.

Nat Cell Biol

2011

13

3

215-222

278

refs

21258342

MED

research support, n.i.h., intramural; journal article; research support, n.i.h., extramural;

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.

John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA, Hager GL, Stamatoyannopoulos JA.

Nat Genet

2011

43

3

264-268

386

refs

21251689

MED

review; journal article;

Dynamic control of endogenous retroviruses during development.

Rowe HM, Trono D.

Virology

2011

411

2

273-287

101

refs

21242971

MED

research-article; journal article; research support, n.i.h., extramural;

Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion.

Yu F, Li J, Chen H, Fu J, Ray S, Huang S, Zheng H, Ai W.

Oncogene

2011

30

18

2161-2172

164

refs

21179060

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Open chromatin in pluripotency and reprogramming.

Gaspar-Maia A, Alajem A, Meshorer E, Ramalho-Santos M.

Nat Rev Mol Cell Biol

2011

12

1

36-47

200

refs

21138846

MED

research support, non-u.s. gov't; research-article; journal article;

Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.

Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M.

J Biol Chem

2011

286

6

4760-4771

101

refs

21112560

MED

letter; research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; research support, n.i.h., extramural;

Reprogramming of human primary somatic cells by OCT4 and chemical compounds.

Zhu S, Li W, Zhou H, Wei W, Ambasudhan R, Lin T, Kim J, Zhang K, Ding S.

Cell Stem Cell

2010

7

6

651-655

288

refs

21057492

MED

research support, non-u.s. gov't; journal article;

Direct conversion of human fibroblasts to multilineage blood progenitors.

Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, Fiebig-Comyn A, Levadoux-Martin M, Bhatia M.

Nature

2010

468

7323

521-526

354

refs

21074045

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.

Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR.

Cell

2010

143

4

527-539

565

refs

21074044

MED

research support, non-u.s. gov't; research-article; review; journal article;

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues.

Hanna JH, Saha K, Jaenisch R.

Cell

2010

143

4

508-525

341

refs

20971919

MED

research support, non-u.s. gov't; review-article; review; journal article; research support, n.i.h., extramural;

Child health, developmental plasticity, and epigenetic programming.

Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K.

Endocr Rev

2011

32

2

159-224

199

refs

20956998

MED

research support, non-u.s. gov't; research-article; journal article;

Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules.

Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H.

Cell Res

2011

21

1

196-204

137

refs

21030644

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Molecular signals of epigenetic states.

Bonasio R, Tu S, Reinberg D.

Science

2010

330

6004

612-616

348

refs

20959618

MED

research-article; review; journal article; research support, n.i.h., extramural;

Mammalian Krüppel-like factors in health and diseases.

McConnell BB, Yang VW.

Physiol Rev

2010

90

4

1337-1381

306

refs

20952534

MED

research support, non-u.s. gov't; review-article; review; journal article;

Induced pluripotency: history, mechanisms, and applications.

Stadtfeld M, Hochedlinger K.

Genes Dev

2010

24

20

2239-2263

368

refs

20946988

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH.

Cell

2010

143

2

313-324

325

refs

20944600

MED

research support, non-u.s. gov't; review; journal article; research support, n.i.h., extramural;

Epigenetic modifications in pluripotent and differentiated cells.

Meissner A.

Nat Biotechnol

2010

28

10

1079-1088

184

refs

20887958

MED

research support, non-u.s. gov't; journal article;

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

Wilson NK, Foster SD, Wang X, Knezevic K, Schütte J, Kaimakis P, Chilarska PM, Kinston S, Ouwehand WH, Dzierzak E, Pimanda JE, de Bruijn MF, Göttgens B.

Cell Stem Cell

2010

7

4

532-544

333

refs

20869108

MED

research support, non-u.s. gov't; research-article; journal article;

EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting.

Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson DB, Doddrell RD, Nakayama M, Adams RH, Lloyd AC.

Cell

2010

143

1

145-155

153

refs

20715179

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN.

Stem Cells

2010

28

10

1728-1740

191

refs

20888316

MED

research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural;

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ.

Cell Stem Cell

2010

7

5

618-630

1019

refs

20870751

MED

research support, non-u.s. gov't; research-article; journal article;

Regulation of somatic cell reprogramming through inducible mir-302 expression.

Lin SL, Chang DC, Lin CH, Ying SY, Leu D, Wu DT.

Nucleic Acids Res

2011

39

3

1054-1065

159

refs

20838411

MED

research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural;

Advances in understanding tissue regenerative capacity and mechanisms in animals.

Poss KD.

Nat Rev G