Hevner4/16/2019

CURRICULUM VITAE

Robert F. Hevner, M.D., Ph.D

Professor of PathologyDirector of Neuropathology

University of California San Diego

Address: Department of Pathology, M/C #77239300 Campus Point DriveLa Jolla, CA 92037Phone: (858) 249-1938Email: rhevner@ucsd.edu

Education

1979-1983 B.S., University of Michigan, Ann ArborCollege of Literature, Science, and the Arts

1984-1992 M.D.-Ph.D., Medical College of Wisconsin, MilwaukeeMedical Scientist Training Program

Degrees

1983 B.S.Cellular and Molecular Biologywith High HonorsUniversity of Michigan

1991 Ph.D.Neuroscience (Advisor: M. Wong-Riley)Medical College of Wisconsin

1992 M.D.Medical College of Wisconsin

Postgraduate Training

1992 - 1994 Pathology ResidentBrigham and Women’s Hospital / Harvard MedicalBoston, MA

1994 - 1996 Neuropathology FellowStanford University Medical Center

1

Hevner4/16/2019

1996 - 2000 Postdoctoral Research FellowUCSF

Faculty Positions

1996 - 1998 Acting Assistant ProfessorDepartment of PathologyStanford University School of Medicine

1998 - 2000 Research Assistant ProfessorDepartment of PsychiatryUCSF

2000 - 2006 Assistant ProfessorDepartment of PathologyUniversity of Washington, Seattle

2006 - 2008 Associate ProfessorDepartment of PathologyUniversity of Washington, Seattle

2007 - 2008 Associate ProfessorDepartment of Neurological SurgeryUniversity of Washington, Seattle

2008 - 2018 ProfessorDepartments of Neurological Surgery and PathologyUniversity of Washington, Seattle

2018 - present Professor of PathologyDirector of NeuropathologyUniversity of California, San Diego

Hospital Positions

2000 - 2018 NeuropathologyUW Medicine, Harborview Hospital,and Seattle Cancer Care Alliance

2008 - 2018 Seattle Children’s HospitalSurgical & Autopsy Neuropathology

2018 - present UCSD Health Systems(pending) Surgical & Autopsy Neuropathology

Honors and Awards

2

Hevner4/16/2019

1991 Outstanding Dissertation AwardMedical College of Wisconsin

1991 Cortical Scholar AwardCajal Club

1992 Alpha Omega Alpha Medical Honor Society

1995 Edwin Baldrey Award for Neurological ResearchSan Francisco Neurological Society

1996 – 2003 Clinical Investigator Award (K08)NINDS

1997 Weil Award for Neuropathology ResearchAmerican Association of Neuropathologists

2002 Marian E. Smith Award for Junior Faculty ResearchUniversity of Washington School of Medicine

2002 – 2005 40th Mallinckrodt ScholarEdward Mallinckrodt, Jr. Foundation

2003 – 2006 Shaw Award for Neuropathology ResearchUW Pathology

2003 – 2007 Independent Scientist Award (K02)NINDS

2005 Kurt Jellinger Award in Neuropathology PublicationActa Neuropathologica

2011 SFARI Explorer AwardSimons Foundation

2016 Ron Lemire Embryology Lecture (Invited)Seattle Children's Hospital, Dept of PediatricsWatch online video

Medical Licenses

1994 - present Medical Board of California (G79432)

2001 - present Medical Board of Washington (MD39397)

3

Hevner4/16/2019

Board Certification

1997 - present Anatomic Pathology and NeuropathologyAmerican Board of Pathology

Subspecialty Training

03/2006 Course on "Developmental Neuropathology"European Confederation of Neuropathological Societies (Euro-CNS)Oxford, UK

Leadership Training

05/2019 "Creating a Culture of Respect"UCSD, San Diego, CA

01/2019 "Managing Disruptive Faculty"UCSD, San Diego, CA

04/2019 "Understanding Generational Differences: Improving Teaching and Training in Academic Medicine"UCSD, San Diego, CA

Organizations / Memberships / Offices

1986 - present Society for Neuroscience

1999 - present American Association of NeuropathologistsChair, Awards Committee (2005 – 2006)Executive Council (2010 – 2015)Vice President (2013 – 2014)

Affiliations at University of California, San Diego

2018 - present Sanford Consortium for Regenerative Medicine

2019 - present Biomedical Sciences Graduate Program

Affiliations at University of Washington

2001 - 2018 Molecular Medicine and Molecular Basis of DiseaseGraduate Program

2001 - 2018 Neurobiology & Behavior Graduate Program

4

Hevner4/16/2019

2005 – 2018 Center for Human Development and Disability

2007 – 2018 Molecular & Cellular Biology Graduate Program

2007 – 2018 Institute for Stem Cell & Regenerative Medicine

2008 – 2018 Center for Integrative Brain ResearchSeattle Children’s Research Institute

Teaching at UCSD

Didactic Sessions for UCSD Residents and Fellows

Fall 2018 Microscopy and PhotomicroscopyPathology residents1 session

Teaching at University of Washington

Graduate Courses

Spring 2002 CONJ 524Development of the Nervous System2 sessions (12% of overall course responsibilities)

Spring 2003 PATH 501Molecular Basis of Neurological DiseasesCourse Director8 sessions (100% of overall course responsibilities)

Fall 2003 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Fall 2004 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Fall 2005 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Fall 2006 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

5

Hevner4/16/2019

Fall 2007 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Fall 2009 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Fall 2010 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Fall 2011 PATH 513Molecular Basis of Neurodegeneration2 lectures (10% of overall course responsibilities)

Didactic Sessions for UW Residents and Fellows

December 2004 Developmental NeuropathologyPathology Residents2 sessions

September 2005 Developmental NeuropathologyRadiology Residents2 sessions

December 2005 Developmental NeuropathologyPathology Residents2 sessions

September 2006 Developmental NeuropathologyRadiology Residents2 sessions

December 2006 Malformations of Cortical DevelopmentPathology Residents1 session

December 2006 Developmental NeuropathologyPathology Residents2 sessions

October 2007 Developmental NeuropathologyRadiology Residents1 session

6

Hevner4/16/2019

April 2008 Developmental NeuropathologyRadiology Residents1 session

April 2008 Brain Malformations and EpilepsyPediatric Neurology1 session

May 2010 Developmental NeuropathologyPathology Residents2 sessions

Trainees

Postdoctoral Fellows

2001 - 2002 Chin-Hsing Lin, Ph.D.

2002 - 2003 Takatoshi Ueki, Ph.D.Currently: Associate ProfessorHamamatsu University School of Medicine

2005 – 2007 Timothy Myshrall, D.V.M., M.P.H.Currently: Assistant Director, Veterinary ServicesCleveland Clinic

2005 – 2010 Francesco Bedogni, Ph.D.Currently: Research ScientistDIBIT, San Raffaele Research Institute, Milan

2005 – 2013 Rebecca Hodge, Ph.D.Currently: Scientist IIAllen Institute for Brain Science, Seattle

2009 – 2011 Naoko Shiba, M.D.Currently: PediatricsShinsu University School of Medicine, Japan

2008 – 2013 Branden Nelson, Ph.D.Currently: Research ScientistSeattle Children’s Research Institute

2009 – 2012 Gina Elsen, Ph.D.Currently: Research ScientistUniversity of Tübingen

7

Hevner4/16/2019

2009 – 2010 Gordana Juric-Sekhar, M.D.Currently: Assistant ProfessorDepartment of PathologyUniversity of Washington

2009 – 2012 Rob Kahoud, M.D.Currently: Assistant ProfessorDepartment of PediatricsMayo Clinic, MN

2013 – 2015 Ashlie Tronnes, M.D.Currently: Obstetrics & GynecologyPortland, OR

2013 – 2015 Ashley McDonough, Ph.D.Currently: Research Associate, UW

2014 – 2015 Prem Tripathi, Ph.D.Currently: Assistant ProfessorAmity Institute of Neuropsychology & Neurosciences, Amity University, Noida, India

2013 – 2018 Anca Mihalas, Ph.D.Currently: Research Associate, UW

2015 – 2018 James Bales, M.D., Ph.D.Neurosurgery

2016 – 2018 Brian Hanak, M.D.Neurosurgery

2016 – 2018 Eitan Kaplan, Ph.D.Currently: Research Associate, UW

2019 – present Michigo Shigyo, Ph.D.

Graduate Students

2006 - 2008 Chris EnglundNeurobiology & Behavior

2006 – 2008 Adria PontiousMolecular Basis of Disease (M.S., 2009)

2009 – 2015 Curtis EastonNeurobiology & Behavior (Ph.D., 2015)

8

Hevner4/16/2019

2013 – 2018 Anthony CastanzaMolecular Basis of Disease

2019 – present Alanna KoehlerBiomedical Sciences

Doctoral Thesis Committees

2005 - 2008 Beryl Hatton (Olson lab, FHCRC)

2007 – 2009 Mary Nivison (Montine lab, UW)

2007 – 2009 P. J. Cimino (Montine lab, UW)

2008 – 2012 Yung-Wei Josh Pan (Xia lab, UW)

2009 – 2013 Michelle Lee (Olson lab, FHCRC)

2012 – 2015 Chad Toledo (Paddison lab, FHCRC)

2012 – 2013 Mollie Woodworth (Macklis lab, Harvard)

2016 – 2018 Chelsea Pagan (Ramirez lab, SCRI)

2016 – 2017 Eric Nealy (Olson lab, FHCRC)

2016 – 2019 Laurie C. Delatour (Yeh lab, Dartmouth)

Undergraduate Students

2001 - 2003 Tina Neogi University of Washington

2001 Keonna Harris UW GenOM Scholar

2002 – 2004 Diane PhamSeattle University

2002 – 2005 Chris EnglundUW Mary Gates Scholar

2002 Julian JohnsonUW BRIDGES4 Scholar

9

Hevner4/16/2019

2002 - 2004 Andrew FinkUW Mary Gates Scholar

2004 - 2005 Avner Neri DaganUniversity of Washington

2004 – 2006 Tom KowalczykUW Mary Gates Scholar

2004 - 2006 Sheung Ming Charmaine LauUniversity of Washington

2005 - 2006 Arshiya QuadriUniversity of Washington

2007 - 2010 Roderick YangUniversity of Washington

2008 - 2010 Amelia BachledaUniversity of Washington

2009 Erika FrederickStanford University Summer Student

2009 Jamison LeidPhysician Scientist Training ProgramUniversity of Pennsylvania Summer Student

2011 – 2015 Michelle LaUW Mary Gates Scholar

2013 Erica YoungUniversity of San Diego Summer Student

2014 Lauren HonicanMiddlebury Summer StudentDept. of Neurological Surgery Summer Program

2014 – 2016 Kevyn RamosUW Honors Program

2015 Carolyn TranMacalester College Summer StudentDept. of Neurological Surgery Summer Program

10

Hevner4/16/2019

2015 Caitlin KierumDept. of Neurological Surgery Summer Program

2016 – present Matt SieversUniversity of Washington, Neurobiology

2016 Chris ParrinoWashington University Summer StudentDept. of Neurological Surgery Summer Program

2016 Lais ConseicaoUniversity of Washington

2016 – 2018 Jessica LoUniversity of Washington, Neurobiology

2016 – 2017 Sahej WaliaUniversity of Washington, BiochemistryUW GenOM Scholar

2017 – 2018 Komal MandUniversity of Washington

2018 – present David NikoghosyanUCSD

2018 – present Veronica VickersUCSD

Editorial Boards

2005 - 2015 Acta Neuropathologica

2006 – present Journal of Neuropathology & Experimental Neurology

2008 – present Brain Pathology

2009 – 2014 Frontiers in Neuroscience Associate Editor

2009 – 2014 Journal of NeuroscienceAssociate Editor

2011 – 2017 NeuroscienceSection Editor, Development & Regeneration

11

Hevner4/16/2019

2015 – present Cerebral CortexAssociate Editor

Special National and International Responsibilities

Grant Review Panels

2003 NIH Study Section NSD-A (ad hoc)

2003 Italian Telethon Foundation (External Reviewer)

2004 NIH Study Section MDCN-A (ad hoc)

2005, 2006 NIH Study Section NCF (ad hoc)

2005 NSF Review Panel on Developmental Neuroscience

2005 – 2013 NIH Study Section DBD (ad hoc)

2006 NIH Study Section NDPR (ad hoc)

2006 – 2011 UK Medical Research Council (External Reviewer)

2008 March of Dimes Foundation (ad hoc)

2008 NIH Training Grant Review Panel (K99)

2007 – 2011 NIH Study Section NDPR (appointed)

2007 – 2009 Department of Defense Autism Review PanelChair, 2009

2011, 2013 NIMH BRAINS Review Panel

2011 European Research Council (External Reviewer)

2011 – 2012 Department of Defense Autism Review Panel (online)Chair

2015 NIH Outstanding Investigator Awards (R35)

2015 - 2017 NIH Study Sections MNG, DBD (ad hoc)

2017 NIH Study Section ZNS1 SRB- A(08)"Rapid Assessment of Zika Virus Complications"

12

Hevner4/16/2019

2018 – 2022 NIH Study Section MNG (appointed)

Special Local Responsibilities

Alzheimer's Disease Research Center at UCSD

2018-present Co-Director, Neuropathology CoreShiley-Marcos Alzheimer's Disease Research Center

Grant Review Panels at University of Washington

2005, 2010, 2017 Royalty Research Fund (Scientific Reviewer)University of Washington

2017 ITHS Pilot Awards (Scientific Reviewer)University of Washington

Recruitment Committees at University of Washington

2010 Recruitment Committee for Center DirectorCenter for Global Infectious Disease ResearchSeattle Children’s Research Institute

2013 Recruitment Committee for Department ChairDepartment of LaboratoriesSeattle Children’s Hospital

External Research Funding

Current Funding

2019 - 2024 NIH / NIA P30 AG062429 (Brewer, PI)Role: Co-Director of Neuropathology Core (0.6 cal)Alzheimer's Disease Research Center$ 2,000,000 annual direct

2016 - 2020 NIH / NINDS R01 NS092339 (Hevner, PI)Role: Principal Investigator"Development and Malformations of the Dentate Gyrus"$1,093,750 total direct costs

Pending Applications for Funding

13

Hevner4/16/2019

2019 - 2021 Alzheimer's Drug Discovery Foundation — Harrington

Scholar (Hevner, PI)Role: Principal Investigator"Regeneration of entorhinal-hippocampal pathways"$300,000 annual direct costs for two years

2019 - 2020 Developmental Studies Hyrbidoma Bank Atlas Grant (Hevner, PI)Role: PI" Antibodies to study the development of neuron clusters in entorhinal cortex"$25,000 total direct costs for one year

Completed Funding

2013 - 2018 NIH / NINDS R01 NS085081 (Hevner, PI)Role: Principal Investigator"Intermediate Neuronal Progenitors in Neocortical Development"$1,093,750 total direct costs

2015 - 2018 NIH / NINDS R01 NS092772 (Dobyns, PI)Role: Co-Investigator"Megalencephaly and segmental brain overgrowth in humans"$2,259,258 total direct costs

2017 - 2018 SCRI OSIP (Hevner, PI)Role: Principal Investigator"Delivery of protein therapeutics to the central nervous system via implantation of immune-evading capsules of self-renewing engineered cells: A feasibility study "$35,000 total direct costs

2016 - 2017 SCRI Accelerator Fund Award (Hevner, PI)Role: Principal Investigator"Application of novel anti-inflammatory coatings to reduce ventricular catheter occlusion"$80,000 total direct costs

2013 - 2014 NIH / NIMH R21 MH099628 (Hevner, PI)"Mosaic Xlr3 Gene Expression in the Female Embryonic Mouse Brain"

14

Hevner4/16/2019

$275,000 total direct costs

2008 – 2013 NIH / NIMH R01 MH058869 (Hevner, Pl)“Intermediate Progenitor Cells in Adult Hippocampal Neurogenesis”$1,125,000 total direct costs

2012 – 2013 CHARGE Syndrome Foundation (Hevner, Pl)“Cerebral Cortex Development in a Mouse Model of CHARGE Syndrome”$50,000 total direct costs

2011 – 2012 Simons Foundation for Autism Research (Hevner, Pl)SFARI Explorer Award (Award Number 219475)“Perturbed Cortical Patterning in Autism”$50,000 total direct costs

2009 – 2011 NIH / NIMH R21 MH087070 (Hevner; Pl)“Delta-Notch Signaling by Intermediate Neuronal Progenitors: Live Imaging”$275,000 total direct costs

2009 – 2011 NIH / NIMH 3R01 MH080766-02S1 (Hevner, Pl)“Intermediate Progenitor Cells in Adult Hippocampal Neurogenesis” (Supplement to Study Development)$300,000 total direct costs

2005 – 2010 NIH / NINDS R01 NS050248 (Hevner, Pl)“Mechanisms of Neocortical Development Regulated by Tbr1”$1,156,250 total direct costs

2003 – 2007 NIH / NINDS K02 NS045018 (Hevner, Pl)Independent Scientist Award"Regulation of Laminar Fate in Cerebral Cortex"$529,200 total direct costs

2006 – 2007 UW / Royalty Research Fund (Hevner, Pl)"Genetic Lineage Tracing of Cerebral Cortex Neurons

Derived from Intermediate Progenitor Cells"$30,000 total direct costs

2002 – 2005 Mallinckrodt Foundation (Hevner, PI)40th Mallinckrodt Scholar$210,000 total direct costs

15

Hevner4/16/2019

2002 – 2003 UW / Marian E. Smith Award (Hevner, PI)$20,000 total direct costs

2001 – 2003 Christopher Reeve Paralysis Foundation (Hevner, Pl)“A Screen for Corticospinal Axon Guidance Molecules”$150,000 total direct costs

1996 – 2003 NIH / NINDS K08 NS01973 (Hevner, Pl)Mentored Clinical Scientist Development Award“The Role of Homeobox Genes in Forebrain Development”$529,200 total direct costs

1996 Howard Hughes Medical Institute (Hevner, PI)Physician Postdoctoral Fellowship$54,000 total direct costs (first year)Resigned in favor of NIH K08 Award

Consulting

Research Consulting

2013 Allen Institute for Brain ScienceBrainSpan Atlas of the Developing Human BrainReference Atlas

Medicolegal Consulting

2015 King County Department of Public DefenseTectal plate glioma and traumatic brain injury

2016 Donnelly Nelson Depolo & MurrayCongenital encephalitis

2019 Phillips Parker Orberson & Arnett, PLCNeonatal hypoxia-ischemia

16

Hevner4/16/2019

Bibliography

Complete Bibliography at Google ScholarCitation Statistics as of October 29, 2018:h-index: 61

Articles in Refereed, PubMed-Indexed Journals (My Bibliography):https://www.ncbi.nlm.nih.gov/sites/myncbi/robert.hevner.1/bibliography/41155071/public/?sort=date&direction=descending

1. MacDonald HS, Kushnaryov VM, Hevner R, Sedmak JJ, Grossberg SE (1986) Mouse β-interferon reduces RNA efflux from isolated nuclei. Interferon Res. 6, 247- 250. (PMID: 2427622)

2. Luo XG, Hevner RF, Wong-Riley MTT (1989) Double labeling of cytochrome oxidase and γ-aminobutyric acid in central nervous system neurons of adult cats. J. Neurosci. Meth. 30, 189-195. (PMID: 2558260)

3. Hevner RF, Wong-Riley MTT (1989) Brain cytochrome oxidase: purification, antibody production, and immunohistochemical/histochemical correlations in the CNS. J. Neurosci. 9, 3884-3898. (PMID: 2555458)

4. Hevner RF, Wong-Riley MTT (1990) Regulation of cytochrome oxidase protein levels by functional activity in the macaque monkey visual system. J. Neurosci. 10, 1331-1340. (PMID: 2158531)

5. Hevner RF, Wong-Riley MTT (1991) Neuronal expression of nuclear and mitochondrial genes for cytochrome oxidase (CO) subunits analyzed by in situ hybridization: comparison with CO activity and protein. J. Neurosci. 11, 1942-1958. (PMID: 1648602)

6. Hevner RF, Duff RS, Wong-Riley MTT (1992) Coordination of ATP production and consumption in brain: parallel regulation of cytochrome oxidase and Na+,K+-ATPase. Neurosci. Lett. 138, 188-192. (PMID: 1328957)

7. Hevner RF, Wong-Riley MTT (1992) Entorhinal cortex of the human, monkey, and rat: metabolic map as revealed by cytochrome oxidase. J. Comp. Neurol. 326, 451-469. (PMID: 1334980)

8. Wong-Riley MTT, Hevner RF, Cutlan R, Earnest M, Egan R, Frost J, Nguyen T (1993) Cytochrome oxidase in the human visual cortex: Distribution in the developing and the adult brain. Vis. Neurosci. 10, 41-58. (PMID: 8381019)

9. Hevner RF, Liu S, Wong-Riley MTT (1993) An optimized method for determining cytochrome oxidase activity in brain tissue homogenates. J. Neurosci. Meth. 50, 309-319. (PMID: 8152242)

17

Hevner4/16/2019

10. Hevner RF, Wong-Riley MTT (1993) Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionately regulated by functional activity in neurons. J. Neurosci. 13, 1805-19. (PMID: 8386752)

11. Hevner RF (1993) More modules. Trends Neurosci. 16, 178. (PMID: 7685940)

12. Hevner RF, Liu S, Wong-Riley MTT (1995) A metabolic map of cytochrome oxidase in the rat brain: Histochemical, densitometric, and biochemical studies. Neuroscience 65, 313-342. (PMID: 7777153)

13. Anthony DC, Hevner RF (1995) Advances in the genetics of hereditary peripheral neuropathies. Adv. Anat. Pathol. 2, 283-298.

14. Hevner RF, Horoupian DS (1996) Pena-Shokeir phenotype associated with bilateral opercular polymicrogyria. Ped. Neurol. 15, 348-351. (PMID: 8972538)

15. Hevner RF, Kinney HC (1996) Reciprocal entorhinal-hippocampal connections established early in human fetal gestation. J. Comp. Neurol. 372, 384-394. (PMID: 8873867)

16. Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen RA, Rubenstein JLR (1996) Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Dev. Biol. 178, 174-178. (PMID: 8812118)

17. Chang SD, Steinberg GK, Rosario M, Crowley RS, Hevner RF (1997) Mixed arteriovenous malformation and capillary telangiectasia: a rare subset of mixed vascular malformations. Case report. J. Neurosurg. 86, 699-703. (PMID: 9120635)

18. Hevner R, Sobel RA (1997) Case of the Month: Premature baby with lethargy and coma. Brain Pathol. 7, 839-840. (PMID: 9161734)

19. Wong-Riley M, Antuono P, Ho K-C, Egan R, Hevner R, Liebl W, Huang Z, Rachel R, Jones J (1997) Cytochrome oxidase in Alzheimer's disease: biochemical, histochemical, and immunohistochemical analyses of the visual and other systems. Vision Res. 37, 3593-3608. (PMID: 9425533)

20. Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S, Meneses J, Pedersen R, Axel R, Rubenstein JLR (1998) An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron 21, 1273-1282. (PMID: 9883721)

18

Hevner4/16/2019

21. Shelbourne PF, Killeen N, Hevner RF, Johnston HM, Tecott L, Lewandoski M, Ennis M, Ramirez L, Li Z, lannicola C, Littmann DR, Myers RM (1999) A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Hum. Mol. Genet. 8, 763-774. (PMID: 10196365)

22. Rubenstein JLR, Anderson S, Shi L, Miyashita-Lin E, Bulfone A, Hevner R (1999) Genetic control of cortical regionalization and connectivity. Cereb. Cortex 9, 524-532. (PMID: 10498270)

23. Miyashita-Lin E§, Hevner R§, Wassarman KM, Martinez S, Martin GR, Rubenstein JLR (1999) Early neocortical regionalization in the absence of thalamic innervation. Science 285, 906-909. (§contributed equally) (PMID: 10436162)

24. Barkovich AJ, Hevner R, Guerrini R (1999) Syndromes of bilateral symmetrical polymicrogyria. AJNR Am. J. Neuroradiol. 20, 1814-1821. (PMID: 10588102)

25. Hevner RF (2000) Development of connections in the human visual system during fetal mid-gestation: a DiI-tracing study. J. Neuropathol. Exp. Neurol. 59, 385-392. (PMID: 10888368)

26. Simon EM, Hevner R, Pinter JD, Clegg NJ, Miller VS, Kinsman SL, Hahn JS, Barkovich AJ (2000) Assessment of the deep gray nuclei in holoprosencephaly. AJNR Am. J. Neuroradiol. 21, 1955-1961. (PMID: 11110554)

27. Pleasure SJ§, Anderson S§, Hevner R§, Bagri A, Marin 0, Lowenstein DH, Rubenstein JLR (2000) Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron 28, 727-740. (§contributed equally) (PMID: 11163262)

28. Simon EM, Hevner RF, Pinter JD, Clegg NJ, Delgado M, Kinsman SL, Hahn JS, Barkovich AJ (2001) The dorsal cyst in holoprosencephaly and the role of the thalamus in its formation. Neuroradiology 43, 787-791. (PMID: 11594433)

29. *Hevner RF, Shi L, Justice N, Hsueh Y-P, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JLR (2001) Tbr1 regulates differentiation of the preplate and layer 6. Neuron 29, 353-366. (PMID: 11239428)*Selected for accompanying Previews article. See: Dwyer ND, O'Leary DDM (2001) Tbr1 conducts the orchestration of early cortical development. Neuron 29, 309-311.

19

Hevner4/16/2019

30. Simon EM, Hevner RF, Pinter JD, Clegg NJ, Delgado M, Kinsman SL, Hahn JS, Barkovich AJ (2002) The middle interhemispheric variant of holoprosencephaly. AJNR Am. J. Neuroradiol. 23, 151-155. (PMID: 11827888)

31. Hevner RF, Miyashita-Lin E, Rubenstein JL (2002) Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J. Comp. Neurol. 447, 8-17. (PMID: 11967891)

32. Hevner RF, Neogi T, Englund C, Daza RAM, Fink A (2003) Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin. Brain Res. Dev. Brain Res. 141, 39-53. (PMID: 12644247)

33. Hevner RF, Daza RAM, Rubenstein JLR, Stunnenberg H, Olavarria JF, Englund C (2003) Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Dev. Neurosci. 25, 139-151. (PMID: 12966212)

34. *Hevner RF, Vilela MD, Rostomily RC, Cohrs RJ, Mahalingam R, Wellish M, Gilden DH (2003) An unusual cause of trigeminal-distribution pain and tumour. Lancet Neurol. 2, 567-571. (PMID: 12941580)*Selected as one of the top 5 papers on neurological infection in 2003. See: Kennedy PGE (2004) 2003 Roundup: Neurological infection. Lancet Neurol. 3, 13.

35. Ueki T, Tanaka M, Yamashita K, Mikawa S, Qiu Z, Maragakis NJ, Hevner RF, Miura N, Sugimura H, Sato K (2004) A novel secretory factor, neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus. J. Neurosci. 23, 11732-11740. (PMID: 14684875)

36. Hevner RF, Daza RAM, Englund C, Kohtz J, Fink A (2004) Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration. Neuroscience 124, 605-618. (PMID: 14980731)

37. Englund C, Silbergeld D, Alvord EC Jr, Small R, Hevner RF (2004) A 24- year-old woman with bifrontal headaches. (Case of the Month.) Brain Pathol. 14, 341-342. (PMID: 15446592)

38. Wang T-F, Ding C-N, Wang G-S, Luo S-C, Lin Y-L, Ruan Y, Hevner R, Rubenstein JLR, Hsueh Y-P (2004) Identification of Tbr-1/CASK complex target genes in neurons. J. Neurochem. 91, 1483-1492. (PMID: 15584924)

20

Hevner4/16/2019

39. *Englund C, Fink A, Lau C, Pham D, Daza RAM, Bulfone A, Kowalczyk T, Hevner RF (2005) Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J. Neurosci. 25, 247-251. (PMID: 15634788)*Selected feature article. See: This week in the journal. (2005) J. Neurosci. 25(1), i.

40. Englund C, Folkerth RD, Born D, Lacy JM, Hevner RF (2005) Aberrant neuronal-glial differentiation in Taylor-type focal cortical dysplasia (type llA/B). Acta Neuropathol. 109, 519-533. (PMID: 15877232)

41. Englund C, Alvord EC Jr, Folkerth RD, Silbergeld D, Born DE, Small R, Hevner RF (2005) NeuN expression correlates with reduced mitotic index of neoplastic cells in central neurocytomas. Neuropathol. Appl. Neurobiol. 31, 429-438. (PMID: 16008827)

42. *Hevner RF (2005) The cerebral cortex malformation in thanatophoric dysplasia: neuropathology and pathogenesis. Acta Neuropathol. 110, 208-221. (PMID: 16133544)*Winner of the 2005 Kurt Jellinger Prize. See: Paulus W (2005) Announcing the winner of the 2005 Kurt Jellinger Prize. Acta Neuropathol. 110, 207.

43. Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N (2005) Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells. Proc. Natl. Acad. Sci. USA 102, 15983-15988. (PMID: 16239343)

44. Hevner RF (2006) From radial glia to pyramidal-projection neuron: transcription factor cascades in cerebral cortex development. Mol. Neurobiol. 33, 33-50. (PMID: 16388109)

45. Hevner RF, Hodge RD, Daza RAM, Englund C (2006) Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus. Neurosci. Res. 55, 223-233. (PMID: 16621079)

46. *Fink AJ, Englund C, Daza RAM, Pham D, Lau C, Nivison M, Kowalczyk T, Hevner RF (2006) Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip. J. Neurosci. 26, 3066-3076. (PMID: 16540585)*Selected feature article. See: This week in the journal. (2006) J. Neurosci. 26(11):i.

47. Nemecek AN, Sviri G, Hevner R, Ghodke B, Britz GW (2006) Dissecting aneurysm of the thoracic posterior spinal artery. Case illustration. Neurosurg. Spine 5, 555. (PMID: 17176024)

21

Hevner4/16/2019

48. Englund C, Kowalczyk T, Dagan A, Daza RAM, Lau C, Hevner RF (2006) Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter. J. Neurosci. 26, 9184-9195. (PMID: 16957075)

49. Quinn JC, Molinek M, Martynoga BS, Zaki PA, Faedo A, Bulfone A, Hevner RF, West JD, Price DJ (2007) Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism. Dev. Biol. 302, 50-65. (PMID: 16979618)

50. Hevner RF (2007) Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. J. Neuropathol. Exp. Neurol. 66, 101-109. (PMID: 17278994)

51. Dahlin A, Xia L, Kong W, Hevner R, Wang J (2007) Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience 146, 1193-1211. (PMID: 17408864)

52. Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S (2007) A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat. Neurosci. 10, 1141-1150. (PMID: 17694053)

53. Daza RA, Englund C, Hevner RF (2007) Organotypic slice culture of embryonic brain tissue. CSH Protoc. doi:10/1101/pdb.prot4914. (PMID: 21357004)

54. Hevner RF (2007) Progress on pontocerebellar hypoplasia. Acta Neuropathol. 114, 401-2. (PMID: 17710422)

55. Pontious A, Kowalczyk T, Englund C, Hevner RF (2008) Role of intermediate progenitor cells in cerebral cortex development. Dev. Neurosci. 30, 24-32. (PMID: 18075251)

56. Hodge RD, Kowalczyk TD, Wolf SA, Encinas JM, Rippey C, Enikolopov G, Kempermann G, Hevner RF (2008) Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output. J. Neurosci. 28, 3707-3717. (PMID: 18385329)

57. Heng JI, Nguyen L, Castro D, Zimmer C, Wildner H, Armant 0, Skowronska Krawczyk D, Bedogni F, Matter J-M, Hevner R, Guillemot F (2008) Neurogenin2 controls cortical neuron migration through regulation of Rnd2. Nature 455, 114-118. (PMID: 18690213)

22

Hevner4/16/2019

58. Jissendi-Tchofo P, Doherty D, McGillivray G, Hevner R, Shaw D, Ishak G, Leventer R, Barkovich AJ (2008) Pontine tegmental cap dysplasia: MR imaging and diffusion tensor imaging features of impaired axonal navigation. AJNR Am. J. Neuroradiol. 30, 113-119. (PMID: 18842761; PMCID: PMC3919876)

59. Keene CD, Chang RC, Leverenz JB, Kopyov 0, Perlman S, Hevner RF, Born DE, Bird TD, Montine TJ (2009) A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions. Acta Neuropathol. 117, 329-338. (PMID: 19057918; PMCID: PMC2676786)

60. Kowalczyk T, Pontious A, Englund C, Daza RA, Bedogni F, Hodge R, Attardo A, Bell C, Huttner WB, Hevner RF (2009) Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex. Cereb. Cortex 19, 2439-50. (PMID: 19168665; PMCID: PMC2742596)

61. Thomson RE, Kind PC, Graham NA, Etherson ML, Kennedy J, Fernandes AC, Marques CS, Hevner RF, Iwata T (2009) Fgf receptor 3 activation promotes selective growth and expansion of occipitotemporal cortex. Neural Dev. 4:4. (PMID: 19192266; PMCID: PMC2661882)

62. Stubbs D, DeProto J, Nie K, Englund C, Mahmud I, Hevner R, Molnár Z (2009) Neurovascular congruence during cerebral cortical development. Cereb. Cortex 19 Suppl 1, i32-41. (PMID: 19386634; PMCID: PMC2693536)

63. Iwata T, Hevner RF (2009) Fibroblast growth factor signaling in development of the cerebral cortex. Dev. Growth Diff. 51, 299-323. (PMID: 19379279)

64. Keene CD, Chang R, Stephen C, Nivison M, Nutt SE, Look A, Breyer RM, Horner PJ, Hevner R, Montine TJ (2009) Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. Am. J. Pathol. 174, 2300-9. (PMID: 19389932; PMCID: PMC2684194)

65. Cundiff P, Liu L, Wang Y, Zou J, Pan YW, Abel G, Duan X, Ming GL, Englund C, Hevner R, Xia Z (2009) ERK5 MAP kinase regulates Neurogenin1 during cortical neurogenesis. PLoS One 4, e5204. (PMID: 19365559; PMCID: PMC2664926)

66. Brill MS§, Ninkovic J§, Winpenny E§, Hodge RD§, Ozen I, Yang R, Erdelyi F, Szabo G, Parras C, Guillemot F, Frotscher M, Berninger B, Hevner RF+, Raineteau O+, Götz M+ (2009) Adult generation of glutamatergic olfactory bulb interneurons. Nat. Neurosci. 12, 1524-33. (§contributed equally) (+corresponding authors) (PMID: 19881504; PMCID: PMC2787799)

23

Hevner4/16/2019

67. Rudzinski E, Kapur RP, Hevner R (2010) Fetal akinesia deformation sequence with delayed skeletal muscle maturation and polymicrogyria: evidence for a hypoxic/ischemic pathogenesis. Pediatr. Dev. Pathol. 13, 192- 201. (PMID: 19968489)

68. Bedogni F, Hodge RD, Nelson BR, Frederick EA, Shiba N, Daza RA, Hevner RF (2010) Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology. Gene Expr. Patterns 10, 9-15. (PMID: 19948250; PMCID: PMC2818569)

69. Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein JL, Hevner RF (2010) Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc. Natl. Acad. Sci. USA 107, 13129-34. (PMID: 20615956; PMCID: PMC2919950)

70. Koch H, Huh S, Elsen FP, Hodge R, Bedogni F, Hevner R, Ramirez JM (2010) Prostaglandin E2 induced synaptic plasticity in neocortical networks of organotypic slice cultures. J. Neurosci. 30, 11678-87. (PMID: 20810888; PMCID: PMC3842478)

71. Barkovich J, Hevner RF (2010) Meningeal gyrations. Ann. Neurol. 68, 421-3. (PMID: 20865763)

72. Juric-Sekhar G, Kapur RP, Glass IA, Murray ML, Parnell SE, Hevner RF (2011) Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/Ill. Acta Neuropathol. 121, 545-54. (PMID: 20857301; PMCID: PMC3059390)

73. Boyle MP, Bernard A, Thompson CL, Ng L, Boe A, Mortrud M, Hawrylycz MJ, Jones AR, Hevner RF, Lein ES (2011) Cell-type-specific consequences of reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J. Comp. Neurol. 519, 2061-89. (PMID: 21491433)

74. Hamilton SM, Spencer CM, Harrison WR, Yuva-Paylor LA, Graham DF, Daza RA, Hevner RF, Overbeek PA, Paylor R (2011) Multiple autism-like behaviors in a novel transgenic mouse model. Behav. Brain Res. 218, 29-41. (PMID: 21093492; PMCID: PMC3022332)

75. Hodge RD, Hevner RF (2011) Expression and actions of transcription factors in adult hippocampal neurogenesis. Dev. Neurobiol. 71, 680-9. (PMID: 21412988; PMCID: PMC3134120)

76. Juric-Sekhar G, Adkins J, Doherty D, Hevner R (2012) Joubert syndrome: brain and spinal cord malformations in genetically characterized cases. Acta Neuropathol. 123, 695-709. (PMID: 22331178)

24

Hevner4/16/2019

77. Hevner RF, Haydar TF (2012) The (not necessarily) convoluted role of basal radial glia in cortical neurogenesis. Cereb. Cortex 22, 465-468. (PMID: 22116731; PMCID: PMC3256413)

78. Hodge RD, Kahoud RJ, Hevner RF (2012) Transcriptional control of glutamatergic differentiation during adult neurogenesis. Cell. Mol. Life Sci. 69, 2125-34. (PMID: 22249196; PMCID: PMC3360923)

79. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW (2012) The transcription factor encyclopedia. Genome Biol. 13, R24. (PMID: 22458515; PMCID: PMC3439975)

80. Hodge RD, Nelson BR, Kahoud RJ, Yang R, Mussar KE, Reiner SL, Hevner RF (2012) Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons. J. Neurosci. 32, 6275-87. (PMID: 22553033; PMCID: PMC3366485)

81. Myshrall TD, Moore SA, Ostendorf AP, Satz JS, Kowalczyk T, Nguyen H, Daza RA, Lau C, Campbell KP, Hevner RF (2012) Dystroglycan on radial glia end feet is required for pial basement membrane integrity and columnar organization of the developing cerebral cortex. J. Neuropathol. Exp. Neurol. 71, 1047-63. (PMID: 23147502; PMCID: PMC3512206)

82. Kovach C, Dixit R, Li S, Mattar P, Wilkinson G, Elsen GE, Kurrasch DM, Hevner RF, Schuurmans C (2013) Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex. Cereb. Cortex 23, 1884-900. (PMID: 22735158)

25

Hevner4/16/2019

83. Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner RF, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S (2013) Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Nat. Neurosci. 16, 157-65. (PMID: 23292680)

84. Malik S, Vinukonda G, Vose LR, Diamond D, Bhimavarapu BB, Hu F, Zia MT, Hevner R, Zecevic N, Ballabh P (2013) Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. J. Neurosci. 33, 411-23. (PMID: 23303921; PMCID: PMC3711635)

85. Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ 3rd, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM (2013) Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J. Neurosci. 33, 3633-45. (PMID: 23426690; PMCID: PMC3652398)

86. Elsen GE, Hodge RD, Bedogni F, Daza RA, Nelson BR, Shiba N, Reiner SL, Hevner RF (2013) The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc. Natl. Acad. Sci. USA 110, 4081-6. (PMID: 23431145; PMCID: PMC3593833)

87. Hodge RD, Garcia AJ 3rd, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF (2013) Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J. Neurosci. 33, 4165-80. (PMID: 23447624; PMCID: PMC3623668)

88. Nelson BR, Hodge RD, Bedogni F, Hevner RF (2013) Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling. J. Neurosci. 33, 9122-39. (PMID: 23699523; PMCID: PMC3716275)

89. Pimeisl IM, Tanriver Y, Daza RA, Vauti F, Hevner RF, Arnold HH, Arnold SJ (2013) Generation and characterization of a tamoxifen-inducible Eomes(CreER) mouse line. Genesis 51, 725-33. (PMID: 23897762; PMCID: PMC4112203)

90. Tornero D, Wattananit S, Grønning Madsen M, Koch P, Wood J, Tatarishvili J, Mine Y, Ge R, Monni E, Devaraju K, Hevner RF, Brüstle O, Lindvall O, Kokaia Z (2013) Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery. Brain 136, 3561-77. (PMID: 24148272)

91. Shiba N, Daza RA, Shaffer LG, Barkovich AJ, Dobyns WB, Hevner RF (2013) Neuropathology of brain and spinal malformations in a case of monosomy 1p36. Acta Neuropathol. Commun. 1, 45. (PMID: 24252393; PMCID: PMC3893467)

26

Hevner4/16/2019

92. Jansen LA, Hevner RF, Roden WH, Hahn SH, Jung S, Gospe SM Jr (2014) Glial localization of antiquitin: implications for pyridoxine-dependent epilepsy. Ann. Neurol. 75, 22-32. (PMID: 24122892; PMCID: PMC3945410)

93. Birlea M, Nagel MA, Khmeleva N, Choe A, Kleinschmidt-Demasters B, Hevner R, Boyer P, Lear-Kaul KC, Bos N, Wellish M, Cohrs RJ, Gilden D (2014) Varicella-zoster virus trigeminal ganglioneuritis without rash. Neurology 82, 90-2. (PMID: 24285619; PMCID: PMC3873618)

94. Kahoud RJ, Elsen GE, Hevner RF, Hodge RD (2014) Conditional ablation of Tbr2 results in abnormal development of the olfactory bulbs and subventricular zone-rostral migratory stream. Dev. Dyn. 243, 440-50. (PMID: 24550175; PMCID: PMC3992892)

95. Easton CR, Weir K, Scott A, Moen SP, Barger Z, Folch A, Hevner RF, Moody WJ (2014) Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J. Neurosci. 34, 3854-63. (PMID: 24623764; PMCID: PMC3951690)

96. Sun T, Hevner RF (2014) Growth and folding of the mammalian cerebral cortex: from molecules to malformations. Nat. Rev. Neurosci. 15, 217-32. (PMID: 24646670; PMCID: PMC4107216)

97. Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Ebbert A, Riley ZL, Royall JJ, Aiona K, Arnold JM, Bennet C, Bertagnolli D, Brouner K, Butler S, Caldejon S, Carey A, Cuhaciyan C, Dalley RA, Dee N, Dolbeare TA, Facer BA, Feng D, Fliss TP, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Howard RE, Jochim JM, Kuan CL, Lau C, Lee CK, Lee F, Lemon TA, Lesnar P, McMurray B, Mastan N, Mosqueda N, Naluai-Cecchini T, Ngo NK, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry SE, Stevens A, Pletikos M, Reding M, Roll K, Sandman D, Sarreal M, Shapouri S, Shapovalova NV, Shen EH, Sjoquist N, Slaughterbeck CR, Smith M, Sodt AJ, Williams D, Zöllei L, Fischl B, Gerstein MB, Geschwind DH, Glass IA, Hawrylycz MJ, Hevner RF, Huang H, Jones AR, Knowles JA, Levitt P, Phillips JW, Sestan N, Wohnoutka P, Dang C, Bernard A, Hohmann JG, Lein ES (2014) Transcriptional landscape of the prenatal human brain. Nature 508, 199-206. (PMID: 24695229; PMCID: PMC4105188)

98. Mirzaa GM, Parry DA, Fry AE, Giamanco KA, Schwartzentruber J, Vanstone M, Logan CV, Roberts N, Johnson CA, Singh S, Kholmanskikh SS, Adams C, Hodge RD, Hevner RF, Bonthron DT, Braun KP, Faivre L, Rivière JB, St-Onge J, Gripp KW, Mancini GM, Pang K, Sweeney E, van Esch H, Verbeek N, Wieczorek D, Steinraths M, Majewski J; FORGE Canada Consortium, Boycott KM, Pilz DT, Ross ME, Dobyns WB, Sheridan EG (2014) De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus

27

Hevner4/16/2019

syndrome. Nat. Genet. 46, 510-5. (PMID: 24705253; PMCID: PMC4004933)

99. Vose LR, Vinukonda G, Diamond D, Korumilli R, Hu F, Zia MT, Hevner R, Ballabh P (2014) Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns. Neuroscience 270, 148-57. (PMID: 24735821; PMCID: PMC4044920)

100. Molnár Z, Kaas JH, de Carlos JA, Hevner RF, Lein E, Němec P (2014) Evolution and development of the mammalian cerebral cortex. Brain Behav. Evol. 83, 126-39. (PMID: 24776993; PMCID: PMC4440552)

101. Smith MJ, Wallace AJ, Bennett C, Hasselblatt M, Elert-Dobkowska E, Evans LT, Hickey WF, van Hoff J, Bauer D, Lee A, Hevner RF, Beetz C, du Plessis D, Kilday JP, Newman WG, Evans DG (2014) Germline SMARCE1 mutations predispose to both spinal and cranial clear cell meningiomas. J. Pathol. 234, 436-40. (PMID: 25143307)

102. Joseph JT, Innes AM, Smith AC, Vanstone MR, Schwartzentruber JA, Bulman DE, Majewski J, Daza RA, Hevner RF, Michaud J, Boycott KM; FORGE Canada Consortium (2014) Neuropathologic features of pontocerebellar hypoplasia type 6. J. Neuropathol. Exp. Neurol. 73, 1009-25. (PMID: 25289895)

103. Alfano C, Magrinelli E, Harb K, Hevner RF, Studer M (2014) Postmitotic control of sensory area specification during neocortical development. Nat. Commun. 5, 5632. (PMID: 25476200)

104. Hevner RF (2015) Brain overgrowth in disorders of RTK-PI3K-AKT signaling: a mosaic of malformations. Semin. Perinatol. 39, 36-43. (PMID: 25432429; PMCID: PMC4268391)

105. Jansen LA, Mirzaa GM, Ishak GE, O'Roak BJ, Hiatt JB, Roden WH, Gunter SA, Christian SL, Collins S, Adams C, Rivière JB, St-Onge J, Ojemann JG, Shendure J, Hevner RF, Dobyns WB (2015) PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia. Brain 138, 1613-28. (PMID: 25722288; PMCID: PMC4614119)

106. Hevner RF (2016) Evolution of the mammalian dentate gyrus. J. Comp. Neurol. 524, 578-94. (PMID: 26179319; PMCID: PMC4706817)

107. Easton CR, Dickey CW, Moen SP, Neuzil KE, Barger Z, Anderson TM, Moody WJ, Hevner RF (2015) Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO. Dev. Neurobiol. 76, 705-20. (PMID: 26473411)

28

Hevner4/16/2019

108. Tronnes AA, Koschnitzky J, Daza R, Hitti J, Ramirez JM, Hevner R (2016) Effects of lipopolysaccharide and progesterone exposures on embryonic cerebral cortex development in mice. Reprod. Sci. 23, 771-8. (PMID: 26621965)

109. Mirzaa GM, Campbell CD, Solovieff N, Goold CP, Jansen LA, Menon S, Timms AE, Conti V, Biag JD, Olds C, Boyle EA, Collins S, Ishak G, Poliachik SL, Girisha KM, Yeung KS, Chung BH, Rahikkala E, Gunter SA, McDaniel SS, Macmurdo CF, Bernstein JA, Martin B, Leary RJ, Mahan S, Liu S, Weaver M, Dorschner MO, Jhangiani S, Muzny DM, Boerwinkle E, Gibbs RA, Lupski JR, Shendure J, Saneto RP, Novotny EJ, Wilson CJ, Sellers WR, Morrissey MP, Hevner RF, Ojemann JG, Guerrini R, Murphy LO, Winckler W, Dobyns WB (2015) Association of MTOR mutations with developmental brain disorders, including megalencephaly, focal cortical dysplasia, and pigmentary mosaicism. JAMA Neurol. 73, 836-45. (PMID: 27159400; PMCID: PMC4979321)

110. Bakken TE, Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Dalley RA, Royall JJ, Lemon T, Shapouri S, Aiona K, Arnold J, Bennett JL, Bertagnolli D, Bickley K, Boe A, Brouner K, Butler S, Byrnes E, Caldejon S, Carey A, Cate S, Chapin M, Chen J, Dee N, Desta T, Dolbeare TA, Dotson N, Ebbert A, Fulfs E, Gee G, Gilbert TL, Goldy J, Gourley L, Gregor B, Gu G, Hall J, Haradon Z, Haynor DR, Hejazinia N, Hoerder-Suabedissen A, Howard R, Jochim J, Kinnunen M, Kriedberg A, Kuan CL, Lau C, Lee CK, Lee F, Luong L, Mastan N, May R, Melchor J, Mosqueda N, Mott E, Ngo K, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry S, Pendergraft J, Potekhina L, Reding M, Riley ZL, Roberts T, Rogers B, Roll K, Rosen D, Sandman D, Sarreal M, Shapovalova N, Shi S, Sjoquist N, Sodt AJ, Townsend R, Velasquez L, Wagley U, Wakeman WB, White C, Bennett C, Wu J, Young R, Youngstrom BL, Wohnoutka P, Gibbs RA, Rogers J, Hohmann JG, Hawrylycz MJ, Hevner RF, Molnár Z, Phillips JW, Dang C, Jones AR, Amaral DG, Bernard A, Lein ES (2016) A comprehensive transcriptional map of primate brain development. Nature 535, 367-75. (PMID: 27409810)

111. Mihalas AB, Elsen GE, Bedogni F, Daza RA, Ramos-Laguna KA, Arnold SJ, Hevner RF (2016) Intermediate progenitor cohorts differentially generate cortical layers and require Tbr2 for timely acquisition of neuronal subtype identity. Cell Rep. 16, 92-105. (PMID: 27320921; PMCID: PMC4927342)

112. Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RP, Studholme C, Boldenow E, Vornhagen J, Baldessari A, Dighe MK, Thiel J, Merillat S, Armistead B, Tisoncik-Go J, Green RR, Davis MA, Dewey EC, Fairgrieve MR, Gatenby C, Richards T, Garden GA, Diamond MS, Juul SE, Grant RF, Kuller L, Shaw DW, Ogle J, Gough GM, Lee W, English C, Hevner RF, Dobyns WB, Gale M Jr., Rajagopal L (2016) Fetal brain lesions after

29

Hevner4/16/2019

subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat. Med. 22:1256-9. (PMID: 27618651; PMCID: PMC5365281)

113. Ha S, Tripathi PP, Mihalas AB, Hevner RF, Beier DR (2017) C-terminal region truncation of RELN disrupts an interaction with VLDLR, causing abnormal development of the cerebral cortex and hippocampus. J. Neurosci. 37:960-971. (PMID: 28123028; PMCID: PMC5296787)

114. Mihalas AB, Hevner RF (2017) Control of neuronal development by T-Box genes in the brain. Curr Top Dev Biol. 122:279-312. (PMID: 28057268)

115. Probst S, Daza RA, Bader N, Hummel JF, Weiß M, Tanriver Y, Hevner RF, Arnold SJ (2017) A dual-fluorescence reporter in the Eomes locus for live imaging and medium-term lineage tracing. Genesis 55(8):e23043.

116. Kaplan ES, Ramos-Laguna KA, Mihalas AB, Daza RAM, Hevner RF (2017) Neocortical Sox9+ radial glia generate glutamatergic neurons for all layers, but lack discernible evidence of early laminar fate restriction. Neural Dev. 12(1):14.

117. Alcantara D, Timms AE, Gripp K, Baker L, Park K, Collins S, Cheng C, Stewart F, Mehta SG, Saggar A, Sztriha L, Zombor M, Caluseriu O, Mesterman R, Van Allen MI, Jacquinet A, Ygberg S, Bernstein JA, Wenger AM, Guturu H, Bejerano G, Gomez-Ospina N, Lehman A, Alfei E, Pantaleoni C, Conti V, Guerrini R, Moog U, Graham JM Jr, Hevner R, Dobyns WB, O'Driscoll M, Mirzaa GM (2017) Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly. Brain 140(10):2610-2622.

118. Adams Waldorf KM, Nelson BR, Stencel-Baerenwald JE, Studholme C, Kapur RP, Armistead B, Walker CL, Merillat S, Vornhagen J, Tisoncik-Go J, Baldessari A, Coleman M, Dighe MK, Shaw DWW, Roby JA, Santana-Ufret V, Boldenow E, Li J, Gao X, Davis MA, Swanstrom JA, Jensen K, Widman DG, Baric RS, Medwid JT, Hanley KA, Ogle J, Gough GM, Lee W, English C, Durning WM, Thiel J, Gatenby C, Dewey EC, Fairgrieve MR, Hodge RD, Grant RF, Kuller L, Dobyns WB, Hevner RF, Gale M Jr, Rajagopal L (2018) Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. Nat. Med. 24(3):368-374.

119. Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF (2018) The epigenetic factor landscape of developing neocortex is regulated by transcription factors Pax6→ Tbr2→ Tbr1. Front. Neurosci. 12:571.

120. Dohare P, Kidwai A, Kaur J, Singla P, Krishna S, Klebe D, Zhang X, Hevner R, Ballabh P (2018) GSK3β inhibition restores impaired neurogenesis in preterm neonates with intraventricular hemorrhage. Cereb Cortex [Epub ahead of print]

30

Hevner4/16/2019

121. Mihalas AB, Hevner RF (2018) Clonal analysis reveals laminar fate multipotency and daughter cell apoptosis of mouse cortical intermediate progenitors. Development 145(17): dev164335.

122. Khuu MA, Pagan CM, Nallamothu T, Hevner RF, Hodge RD, Ramirez JM, Garcia AJ 3rd (2018) Intermittent hypoxia disrupts adult neurogenesis and synaptic plasticity in the dentate gyrus. J. Neurosci. [Epub ahead of print]

123. Juric-Sekhar G, Hevner RF (2019) Malformations of cerebral cortex development: molecules and mechanisms. Annu Rev Pathol: Mech. Dis. 4: 293-318.

124. Monteiro FP, Curry CJ, Hevner R, Elliott S, Fisher JH, Turocy J, Dobyns WB, Costa LA, Freitas E, Kitajima JP, Kok F (2019) Biallelic loss of function variants in ATP1A2 cause hydrops fetalis, microcephaly, arthrogryposis and extensive cortical malformations. Eur. J. Med. Genet. [Epub ahead of print].

125. Chang Y-C, Daza R, Hevner R, Costa LG, Cole TB (2019) Prenatal and early life diesel exhaust exposure disrupts cortical lamina organization: evidence for a Reelin-related pathogenic pathway induced by interleukin-6. Brain Behav Immun, in press.

126. Hevner RF (2019) Intermediate progenitors and Tbr2 in cortical development. J Anat, in press.

127. Oosterhof N, Chang IJ, Karimiani EG, Kuil LE, Jensen DM, Daza R, Young E, Astle L, van der Linde HC, Shivaram GM, Demmers J, Latimer CS, Keene CD, Loter E, Maroofian R, van Ham TJ, Hevner RF, Bennett JT (2019) Homozygous mutations in CSF1R cause a pediatric-onset leukoencephalopathy and can result in congenital absence of microglia. Am. J. Hum. Genet. [Epub ahead of print].

31

Hevner4/16/2019

Articles Submitted to Refereed Journals

1. Nambot S, Faivre L, Mirzaa G, Thevenon J, Bruel A-L, Mosca-Boidron A-L, Masurel-Paulet A, Goldenberg A, Le Meur N, Charollais A,Mignot C, Petit F, Rossi M, Metreau J, Layet V, Amram D, Boute-Bénéjean O, Bhoj E, Cousin MA, Kruisselbrink TM, Lanpher BC, Klee EW, Fiala E, Grange DK, Meschino WS, Hiatt SM, Cooper GM, Olivié H, Smith WE, Dumas M, Lehman A, CAUSES Study, Inglese C, Nizon M, Guerrini R, Vetro A, Kaplan ES, Miramar D, Van Gils J, Fergelot P, Bodamer O, Smol T, Piton A, Gérard B, Chantot-Bastaraud S, Bienvenu T, Li D, Juusola J, Devriendt K, Bilan F, Poé C, Chevarin M, Jouan T, Tisserant E, Rivière J-B, Mau-Them FT, Philippe C, Duffourd Y, Dobyns WB, Hevner R, Thauvin-Robinet C (submitted) De novo TBR1 variants cause a neurocognitive phenotype with ID and ASD: description of 22 new cases and review of the literature. Submitted to Eur. J. Hum. Genet. In revision.

Other Publications (Letters, Book Reviews)

1. Hevner RF (2005) Review of "Developmental Neuropathology" (Book Review). Pediatr. Dev. Pathol. 8, 245.

2. Hevner RF (2008) Review of "Malformations of the Nervous System" (Book Review). Pediatr. Dev. Pathol. 7, 1.

Book Chapters

1. Wong-Riley MTT, Nie F, Hevner RF, Liu S (1998) Brain Cytochrome Oxidase: Functional Significance and Bigenomic Regulation in the CNS. In: Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease (F Gonzalez-Lima, ed.), Plenum, New York, Chapter 1, pp. 2-42.

2. Hevner RF (1998) Cytochrome Oxidase and Neuroanatomical Patterns: What is the Connection? In: Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease (F Gonzalez-Lima, ed.), Plenum, New York, Chapter 3, pp. 91-108.

3. Hevner RF (2000) Chemical Senses: Olfaction and Taste. In: Neuroscience Secrets (M Wong-Riley, ed.), Hanley & Belfus, Philadelphia, Chapter 8, pp. 141- 148.

4. Hevner RF (2000) Cranial Nerves and Nuclei. In: Neuroscience Secrets (M Wong-Riley, ed.), Hanley & Belfus, Philadelphia, Chapter 9, pp. 149-166.

5. Hevner RF, Zecevic N (2006) Pioneer Neurons and lnterneurons in the Developing Subplate: Molecular Markers, Cell birthdays, and Neurotransmitters. In: Development and Plasticity in Sensory Thalamus and Cortex (R Erzurumlu, W Guido, Z Molnár, eds.), Springer, New York, Chapter 1, pp. 1-18.

32

Hevner4/16/2019

6. Hevner RF (2008) Reelin and the Cerebellum. In: Reelin Glycoprotein: Biology, Structure, and Roles in Health and Disease (SH Fatemi, ed.), Springer, New York, Chapter 10, pp. 141-158.

7. Sonnen JA, Keene CD, Hevner RF, Montine TJ (2009) Molecular Pathology: Neuropathology. In: Molecular Pathology: The Molecular Basis of Human Disease (1st ed.) (Coleman WB, Tsongalis GJ, eds.), Academic Press, London, Chapter 27, pp. 551-590.

8. Elsen GE, Juric-Sekhar G, Daza RAM, Hevner RF (2013) Development of Cerebellar Nuclei. In: Handbook of the the Cerebellum and Cerebellar Disorders (Manto M, Schmahmann JD, Rossi F, Gruol DL, Koibuchi N, eds.), Springer, New York, Chapter 10, pp. 179-205.

9. Flanagan M, Sonnen JA, Keene CD, Hevner RF, Montine TJ (2018) Molecular Basis of Diseases of the Nervous System. In: Molecular Pathology: The Molecular Basis of Human Disease (2nd ed.) (Coleman WB, Tsongalis GJ, eds.), Academic Press, Oxford, Chapter 29, pp. 652-690.

10. Hevner RF, Millen K, Dobyns WB (2018) Dandy-Walker Malformation, Mega-Cisterna Magna, and Blake's Pouch Cyst. In: Developmental Neuropathology, 2nd Ed. (Adle-Biassette H, Harding B, and Golden JA, eds.), Pathology and Genetics Book Series (Keohane C and Gray F, eds.), International Society of Neuropathology, Wiley-Blackwell, in press.

11. Hevner RF, Dobyns WB, Valente EM (2018) Joubert Syndrome. In: Developmental Neuropathology, 2nd Ed. (Adle-Biassette H, Harding B, and Golden JA, eds.), Pathology and Genetics Book Series (Keohane C and Gray F, eds.), International Society of Neuropathology, Wiley-Blackwell, in press.

12. Mirzaa G, Roy A, Dobyns WB, Millen K, Hevner RF (2018) Hemimegalencephaly and Dysplastic Megalencephaly. In: Developmental Neuropathology, 2nd Ed. (Adle-Biassette H, Harding B, and Golden JA, eds.), Pathology and Genetics Book Series (Keohane C and Gray F, eds.), International Society of Neuropathology, Wiley-Blackwell, in press.

Online Media

1. Hevner RF (2008) "Developmental Neuropathology" PowerPoint teaching presentation with audio narrative, published online at: http://www.pathology.washington.edu/clinical/neuropath/recordedtalks.php

2. Hevner RF (2012) "TBR1" Chapter in Transcription Factor Encyclopedia, published online at: http://cisreg.ca/tfe

33

Hevner4/16/2019

Recent Abstracts (2002 - present)

1. Hevner RF, Neogi T, Englund C, Daza RAM, Fink A (2002) Reelin+ Cajal Retzius cells express pallial markers (Tbr1 and Emx2), are glutamatergic, and are born only during early corticogenesis in mice. Reeler and Friends Workshop. Orlando, FL, November 2, 2002.

2. Hevner RF, Daza RA, Englund C, Neogi T (2002) Cortical neurogenesis: analysis with layer-specific and interneuron-specific markers. AANP Annual Meeting. Published in: J. Neuropathol. Exp. Neurol. 61, 488.

3. Hevner RF, Daza RAM, Englund C, Neogi T (2002) Neurogenesis of cortical neurons: birthdate and expression of layer-specific markers. Society for Neuroscience Annual Meeting. Program No. 724.5. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM.

4. Hevner RF, Lacy JM, Englund C, Born D, Folkerth RD (2003) Co expression of neuronal and glial markers in focal cortical dysplasia: analysis by double labeling immunofluorescence and confocal microscopy. AANP Annual Meeting. Published in: J. Neuropathol. Exp. Neurol. 62, 558.

5. Englund C, Folkerth RD, Silbergeld D, Alvord EC Jr, Small R, Hevner RF (2003) Proliferative potential of NeuN+ cells in neurocytoma. AANP Annual Meeting. Published in: J. Neuropathol. Exp. Neurol. 62, 573.

6. Daza RAM, Englund C, Kohtz J, Hevner RF (2003) Postnatal radial migration of interneurons in normal and reeler mouse cortex. Society for Neuroscience Annual Meeting. Program No. 137.10. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM.

7. Fink AJ, Englund C, Poolos N, Daza RAM, Hevner RF (2003) Tbr1 and the development of the deep cerebellar nuclei. Society for Neuroscience Annual Meeting. Program No. 454.3. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CDROM.

8. Hevner RF, Fink AJ, Englund C, Lau C, Pham D (2004) Expression of Tbr2/Eomesodermin protein in the developing cerebral cortex, olfactory bulb, and cerebellum. Society for Neuroscience Annual Meeting. Program No. 608.17. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM.

9. Hevner RF, Englund C, Fink AJ, Daza RAM, Pham D (2005) Unipolar brush cells of the cerebellum originate from the rhombic lip/germinal trigone and migrate through cerebellar white matter. AANP Annual Meeting. Published in: J. Neuropathol. Exp. Neurol. 64, 466.

34

Hevner4/16/2019

10. Hevner R (2005) Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. Cortical Development: Neural Stem Cells to Neural Circuits. Santorini, Greece, poster P44, program p. 85.

11. Bystron I, Hevner R, Blakemore C (2005) The columnar organisation of the neuroepithelium in the human cortical primordium. Society for Neuroscience Annual Meeting. Program No. 144.3. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM.

12. Englund CM, Kowalczyk T, Dagan A, Daza RAM, Lau C, Hevner RF (2005) Unipolar brush cells of the cerebellum arise from the rhombic lip and migrate via a novel pathway through the cerebellar white matter. Society for Neuroscience Annual Meeting. Program No. 145.2. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM.

13. Hevner RF (2006) Periventricular nodular heterotopia and polymicrogyria in a case of monosomy 1p36. ISN Annual Meeting. Published in: Brain Pathol. 16(Suppl 1), S138.

14. Hodge RD, Kowalczyk T, Rippey C, Hevner RF (2006) Tbr2 is expressed in intermediate stage progenitor cells during neurogenesis in the adult hippocampus. International Society for Developmental Neuroscience. Banff, Alberta, Canada. Poster presentation.

15. Myshrall TD, Moore SA, Ostendorf A, Satz J, Lau C, Campbell KP, Hevner RF (2006) Meningeal heterotopia formation in dystroglycan null mice. Society for Neuroscience Annual Meeting. Program No. 28.5. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

16. Hevner RF (2007) Role of intermediate progenitor cells in cerebral cortex development. Symposium on Cortical Development: Genes and Genetic Abnormalities (Program 39), IBRO World Congress of Neuroscience, Melbourne, Australia.

17. Kowalczyk T, Pontious A, Englund C, Bell C, Hevner RF (2007) Intermediate progenitor cells progressively amplify pyramidal neuron output in neocortical neurogenesis. Stem Cells, Migration and Axon Guidance in the Developing and Adult Brain, IBRO Satellite Meeting S13. Cairns, Australia, p. 43 of symposium printed brochure.

35

Hevner4/16/2019

18. Kowalczyk T, Pontious A, Englund C, Attardo A, Bell C, Huttner WB, Hevner RF (2008) Intermediate progenitor cells throughout cortical neurogenesis: Distinct morphologies, diverse laminar fates, and SVZ/IZ overlap. Cortical Development: Stem Cells, Neurogenesis, Migration, Circuit Formation, Cortical Disorders. Crete, Greece, Poster P40, program p. 56.

19. Englund C, Daza RAM, Hodge RD, Bedogni F, Hevner RF (2008) The role of Tbr2 in morphogenesis of the dentate gyrus. Society for Neuroscience Annual Meeting. Program No. 420.15. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

20. Bedogni F, Hodge RD, Daza RA, Hevner RF (2008) Gene expression analysis of Tbr1–/– cortex during early development. Society for Neuroscience Annual Meeting. Program No. 721.5. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

21. Hodge RD, Bedogni F, Hevner RF (2008) Molecular profile of actively proliferating intermediate progenitor cells in the developing cerebral cortex. Society for Neuroscience Annual Meeting. Program No. 24.7. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

22. Nivison MP, Hodge RD, Hevner RF, Montine TJ (2008) Molecular mechanisms for LPS-induced neuroinflammation on adult mammalian neurogenesis. Society for Neuroscience Annual Meeting. Program No. 356.21. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

23. Bedogni F, Hodge RD, Nelson BR, Shiba N, Daza RA, Hevner RF (2009) Pattern of expression of Auts2: Gradient towards the frontal cortex and relationship to Tbr1. Society for Neuroscience Annual Meeting. Program No. 218.8. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

24. Hodge RD, Hevner RF (2009) Expression of Tbr2 is essential for the maturation of new granule neurons during adult hippocampal neurogenesis. Society for Neuroscience Annual Meeting. Program No. 30.6. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

25. Nelson BR, Hevner RF (2009) Long-range, contact-dependent Delta-Notch signaling during mammalian corticogenesis. Society for Neuroscience Annual Meeting. Program No. 606.21. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

36

Hevner4/16/2019

26. Doi A, Zanella S, Wei A, Bedogni F, Hodge R, Daza R, Hevner R, Ramirez JM (2009) Functional interactions among NK1, alpha1 (NE) and 5-HT2 receptors on respiratory rhythm in the Pre-Bötzinger complex. Society for Neuroscience Annual Meeting. Program No. 270.14. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

27. Hodge RD, Hevner RF (2010) The T-box transcription factor Tbr2 is required for development of the hippocampus and for maintenance of neurogenesis in the postnatal dentate gyrus. Pediatric Academic Society. Vancouver, British Columbia.

28. Elsen GE, Bedogni F, Hodge RD, Nelson BR, Daza RA, Shiba N, Hevner RF (2010) T-box transcription factor Tbr1 coordinates regional and laminar identity of postmitotic neurons in the developing neocortex. Pediatric Academic Society. Vancouver, British Columbia.

29. Kahoud RJ, Hodge RD, Mussar K, Hevner RF (2010) Mechanisms of postnatal and adult subventricular zone neurogenesis regulated by the Tbox transcription factor Tbr2. Pediatric Academic Society. Vancouver, British Columbia.

30. Elsen GE, Bedogni F, Hodge RD, Nelson BR, Daza RA, Shiba N, Hevner RF (2010) Tbr1 coordinates regional and laminar identity of postmitotic neurons in the developing neocortex. International Society for Developmental Neuroscience. Estoril, Portugal. Poster presentation.

31. Easton CR, Conhaim J, Becker Ml, Mather LF, Moore JG, Hevner RF, Moody WJ (2010) Changing propagation patterns and transmitter participation of spontaneous waves of activity in the developing mouse neocortex. Society for Neuroscience Annual Meeting. Program No. 440.9. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

32. Elsen G, Bedogni F, Hodge R, Daza R, Shiba N, Hevner RF (2011) An intermediate map of regional identity regulated by Tbr2 in developing neocortex. Cortical Development: Neural Stem Cells to Neural Circuits. Chania, Crete, Greece.

33. Elsen GE, Hodge RD, Bedogni F, Daza RAM, Shiba N, Reiner S, Hevner RF (2011) Regulation of regional identity by the Pax6-Tbr2-Tbr1 transcription factor cascade in developing mouse neocortex. IBRO World Congress of Neuroscience. Florence, Italy. Poster presentation.

34. Hodge RD, Elsen GE, Nelson BR, Kahoud RJ, Mussar KE, Yang R, Hevner RF (2011) The T-box transcription factor Tbr2 is required for development of the hippocampus and for maintenance of neurogenesis in the adult dentate gyrus. IBRO World Congress of Neuroscience. Florence, Italy. Poster presentation.

37

Hevner4/16/2019

35. Kahoud RJ, Hodge RD, Nelson BR, Elsen GE, Hevner RF (2011) The T-box transcription factor Tbr2 controls glutamatergic fate determinants in the postnatal and adult subventricular zone. IBRO World Congress of Neuroscience. Florence, Italy. Poster presentation.

36. Hodge RD, Elsen GE, Nelson BR, Kahoud RJ, Mussar KE, Yang R, Hevner RF (2011) The T-box transcription factor Tbr2 is required for development of the hippocampus and for maintenance of neurogenesis in the adult dentate gyrus. [Nanosymposium]. Society for Neuroscience Annual Meeting. Program No. 529.06. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

37. Easton CR, Moen SP, Becker MI, Hevner RF, Moody WJ (2011) Morphological development of cortical interneurons in relation to the development of widely propagating waves of activity in the mouse cerebral cortex. Society for Neuroscience Annual Meeting. Program No. 133.07. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

38. Hevner R, Elsen G, Hodge R, Bedogni F, Daza R (2012) Transcriptomic analysis of progenitors and neurons in developing mouse cerebral cortex: regulation of autism-related genes by Pax6, lnsm1, Tbr2, and Tbr1. FENS Forum. Barcelona, Spain, July 2012. Poster presentation.

39. Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner R, Meyer G, Ohshima T, Pleasure SJ, Zhao Y, Tole S (2012) Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream. Society for Neuroscience Annual Meeting. Program No. 230.21. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

40. Easton CR, Moen SP, Weir K, Scott A, Hevner RF, Moody WJ (2013) Two neural networks, one GABAergic and one glutamatergic, interact to generate widely propagating waves of activity in early postnatal mouse cortex. Society for Neuroscience Annual Meeting. Program No. 29.02. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

41. Dickey CW, Easton CR, Hevner RF, Moody WJ (2013) Multiple forms of spontaneous activity in migrating GABAergic interneurons of the developing mouse cortex. Society for Neuroscience Annual Meeting. Program No. 29.05. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

38

Hevner4/16/2019

42. Ramirez JSB, Christakis DA, Hodge RD, Hevner RF, Ravinder S, Ramirez TKM, Smith AF, Burgos MF, Ramirez JM (2013) A mouse model for too much TV: Unraveling the mechanisms and developmental differences in the response to sensory overstimulation. Society for Neuroscience Annual Meeting. Program No. 533.18. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

43. McDonough A, Berletch J, Disteche C, Hevner R (2014) Spatiotemporal dimorphic expression of Xlr3 genes in the developing male and female cortex. Society for Neuroscience Annual Meeting. Program No. 29.02. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

44. Bakken T, Miller J, Ding S-L, Sunkin S, Smith K, Ng L, Szafer A, Goldy J, Lee C, Ebbert A, Dalley R, Dee N, Royall J, Parker PD, Riley Z, Molnár Z, Hevner R, Amaral D, Hawrylycz M, Jones A, Phillips J, Wohnoutka P, Dang C, Bernard A, Hohmann J, Lein E (2014) Spatiotemporal expression atlas of brain development in non-human primate. Society for Neuroscience Annual Meeting. Program No. 494.08. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

45. Mihalas A, Daza R, Ramos K, Young E, Hevner R (2015) T-box transcription factor Tbr2 controls multiple aspects of cortical projection neuron differentiation. Society for Neuroscience Annual Meeting. Program No. 28.06. Abstract online at: http://www.sfn.org/annual-meeting/past-and-future-annual-meetings.

46. Castanza A, Daza R, Hevner R (2017) The role of AUTS2 in synaptic wiring and hippocampal development. Keystone Symposium on "Neurogenesis during Development and in the Adult Brain." Poster No. 1011.

National / International Invitation Lectures

05/1999 "Forebrain Development and Holoprosencephaly" American Society for NeuroradiologySan Diego

09/2002 "Building the Cerebral Cortex: Neuron by Neuron, Layer by Layer''New Investigator LectureUniversity of Washington School of MedicineSeattle

11/2003 "Subplate Neurons and Thalamocortical / Corticothalamic Connections"

39

Hevner4/16/2019

Plasticity in Sensory Thalamus and CortexSatellite SymposiumSociety for Neuroscience Annual MeetingNew Orleans

09/2005 "Sequential Expression of Transcription Factors in the Differentiation of Cortical Projection Neurons"Neuronal Differentiation in Cortical Development Human Frontiers Science ProgramOsaka, Japan

10/2005 "Cortical Neurogenesis and Thanatophoric Dysplasia: More Isn't Better''Jellinger Award LectureGerman Society for Neuropathology and Neuroanatomy Graz, Austria

10/2005 "Cerebral Cortex Development: Specification and Differentiation of Cortical Layers"Pathology Grand RoundsUniversity of Iowa School of MedicineDes Moines

02/2007 "Tbr Genes and Hypotheses of Cerebral CortexDevelopment"University of Colorado Health SciencesDenver

02/2007 "Transcription Factor Cascades in Cortical Development" Symposium on Cortical DevelopmentUniversity of OxfordOxford, UK

02/2007 Cortical Development: Genes and Genetic Abnormalities Novartis Foundation SymposiumLondon, UK

03/2007 "Genetic Disorders of Human Cortical Neurogenesis" University of Colorado Health SciencesDenver

05/2007 "Intermediate Progenitor Cells in Cerebral Cortex Development"Symposium on Neurogenesis 2007Tokyo, Japan

40

Hevner4/16/2019

07/2007 "Intermediate Progenitor Cells Progressively Amplify Pyramidal Neuron Output in Neocortical Neurogenesis" Stem Cells, Migration and Axon Guidance in the Developing and Adult BrainIBRO Satellite SymposiumCairns, Australia

07/2007 "Intermediate Progenitor Cells in Cerebral Cortex Development"IBRO World Congress of Neuroscience Melbourne, Australia

10/2007 "T-domain Transcription Factors in Cerebral Cortex Development"Cornell University Medical CenterNew York, NY

10/2007 "Roles of Tbr1 and Tbr2 in Brain Development and Adult Neurogenesis"Graduate Students Invited LectureUCSD Neurosciences ProgramSan Diego

11/2007 "Regulation of Adult Hippocampal Neurogenesis"Institute for Stem Cell and Regenerative MedicineUniversity of Washington School of MedicineSeattle

12/2007 "Roles of Tbr1 and Tbr2 in Brain Development and Adult Neurogenesis"Department of NeurobiologyUniversity of PittsburghPittsburgh, PA

04/2008 "Axon Guidance Disorders in the Human Brain"Molecular Embryology to MalformationsAANP / ASIP / Experimental BiologySan Diego

08/2008 "Neuroregeneration in the Cerebral Cortex"Neurological Surgery Grand RoundsUniversity of Washington School of MedicineSeattle

41

Hevner4/16/2019

09/2008 "Making the Transition from K to R01 Funding"Career Development SymposiumAmerican Neurological AssociationSalt Lake City

11/2008 "Transcriptional Control of Cortex Development"Pathology PresentsUniversity of Washington School of MedicineSeattle

03/2009 "Progenitor Cells and Transcriptional Programs in Cerebral Cortex Neurogenesis"Department of PharmacologyUniversity of Washington School of MedicineSeattle

03/2009 "Progenitor Cells and Transcriptional Programs in Embryonic and Adult Neurogenesis"NeurofestUpstate Medical UniversitySyracuse

09/2009 "Making the Transition from K08 to R01 Funding" Neurological Surgery Grand RoundsUniversity of Washington School of MedicineSeattle

10/2009 "Transcription factors in cerebral cortex development and malformations"Department of PathologyUniversity of California, Irvine

11/2009 "From Mouse Genes to Einstein's Brain"Center for Integrative Brain Research Seattle Children's Research InstituteSeattle, WA

11/2009 "T-box Transcription Factors in Cortical Neurogenesis" Symposium on Neural DevelopmentGlobal Center of Excellence ProgramNagoya University Medical SchoolNagoya, Aichi, Japan

11/2009 "Transcription Factor Programs in Cortical Neurogenesis" RIKEN Brain Science InstituteWako City, Saitama, Japan

42

Hevner4/16/2019

12/2009 "Tbr1 and Tbr2 Regulate Laminar and Regional Identity of Neocortical Projection Neurons"Department of AnatomyKeio University School of MedicineTokyo

12/2009 "Tbr1 and Tbr2 Regulate Laminar and Regional Identity of Neocortical Projection Neurons"Texas Children's HospitalBaylor University School of MedicineHouston, TX

03/2010 "Tbr1 Regulates Frontal Identity of Developing Neocortex"Neuroscience ProgramHarvard Stem Cell InstituteBoston, MA

04/2010 "Autism and Arealization of the Cerebral Cortex" Autism Autism Research SymposiumCenter for Integrative Brain ResearchSeattle Children's Research InstituteSeattle, WA

05/2010 "Constructing the Cerebral Cortex"Baby Brains: The Development of Functional Neural Circuits Center for Integrative Neuroscience Spring SymposiumUniversity of WashingtonSeattle

10/2010 "From Protomap to Map: Genes that implement regional identity in postmitotic cortical neurons"Cajal Club / Allen Institute / SCRI Regional MeetingSeattle Children's Research InstituteSeattle, WA

04/2011 "Regionalization of the Developing Cerebral Cortex"Center for OrganogenesisUniversity of MichiganAnn Arbor

05/2011 "An Intermediate Map of Cerebral Cortex Regional Identity'' Department of NeurosciencesCase Western Reserve UniversityCleveland

43

Hevner4/16/2019

05/2011 "An Intermediate Map of Cerebral Cortex Regional Identity" Cortical Development: Neural Stem Cells to Neural CircuitsChania, Crete, Greece

06/2011 "Neuronal Migration Abnormalities in Dystroglycanopathies and Related Disorders"Presidential SymposiumAmerican Association of NeuropathologistsSeattle, WA

04/2012 "Getting Excited About Adult Neurogenesis"Symposium on Functional NeurogenesisCenter for Integrative Neuroscience University of WashingtonSeattle

10/2012 "Molecular Expression Profiles of Cortical Progenitors"Allen Institute for Brain SciencesSeattle

11/2012 "Neuropathology in CHARGE Syndrome"Epigenetics and Disease: A Mini-Symposium on CHARGE SyndromeDrexel UniversityPhiladelphia

04/2013 "Molecular and Cellular Characteristics of Cerebral Cortical Intermediate Progenitors"Evolution and development of the mammalian cerebral cortexEuropean Conference on Comparative NeurobiologyBudapest, Hungary

07/2013 "Neuropathology of CHARGE Syndrome"CHARGE Syndrome FoundationScottsdale, AZ

05/2014 "Basal Progenitor Migration and Proliferation in Developingand Adult Dentate Gyrus"Keystone Conference on Adult NeurogenesisStockholm, Sweden

05/2014 "Development and Evolution of the Dentate Gyrus"Cortical Development: Neural Stem Cells to Neural CircuitsChania, Crete, Greece

44

Hevner4/16/2019

06/2014 "Pathology of Hemimegalencephaly"PI3K-AKT, Megalencephaly, and Pediatric Brain TumorsAmerican Association of NeuropathologistsPortland

02/2015 "Development of the Dentate Gyrus"Department of Neurobiology & BehaviorStony Brook UniversityStony Brook, NY

04/2015 "Development of the Dentate Gyrus: A Moveable Niche"17th International Neuroscience Winter ConferenceSölden, Austria

05/2015 "Evolution of the Mammalian Dentate Gyrus"Cortical Evolution Conference 2015Toledo, Spain

04/2016 "Intermediate Progenitors in Cortical Development: Tbr2 and Projection Neuron Fates"18th International Neuroscience Winter ConferenceSölden, Austria

04/2016 "Autism Genes that Regulate Development of Glutamatergic Pyramidal Neurons"Biology of Autism CRA Symposium on Autism: Genes, Brain, and the EnvironmentSeattle

11/2016 "The Brain in Autism: Neurodevelopment and Neuropathology"Ron Lemire Embryology LectureSeattle Children's Hospital Grand Rounds

06/2017 "Cellular and Molecular Development of the Dentate Gyrus"Spring Hippocampal Research ConferenceTaormina, Italy

07/2018 "Evolution of Cortical Progenitor Cells"Summer Meeting of the Anatomical SocietySt. John's College, Oxford, UK

10/2018 "TBR1 and AUTS2 Regulate Cortical Development in Mice and Humans"American Academy of Child and Adolescent Psychiatry 65th Annual Meeting

45

Hevner4/16/2019

Seattle, WA, USA

04/2019 "Intermediate Progenitor Cells in Cortical Development"Dartmouth University, Department of Molecular & Systems BiologyHanover, NH, USA

07/2019 "Epigenetic Factors in Cortical Development"2nd Annual ASXL Summer MeetingAnn Arbor, MI, USA

08/2019 "Progenitor Cells in Cerebral Cortex Development"Symposium: Signaling Mechanisms in Cortical DevelopmentInternational Society for Neurochemistry MeetingMontreal, Quebec, Canada

02/2020 "Neuropathology of Pediatric Epilepsy"Symposium on Pediatric EpilepsyEuropean Course on MRI in NeuropediatricsMarseille, France

Meetings or Symposia Organized

04/2008 Molecular Embryology to MalformationsCo-organizers: Hevner RF, Golden JASpecial CourseAmerican Association of NeuropathologistsAANP / ASIP / Experimental BiologySan Diego

10/2010 The Human Brain: Genes, Development and Connections inthe 21st CenturyCo-Organizers: Ribak C, Holman J, Hevner R, Rubenstein JCajal Club SymposiumSeattle

06/2014 PI3K-AKT, Megalencephaly, and Pediatric Brain TumorsCo-organizers: Hevner RF, Yachnis ASpecial CourseAmerican Association of NeuropathologistsPortland

46

Hevner4/16/2019

04/2016 Becoming a cortical neuron: identity and diversityCo-organizers: Hevner RF, Tarabykin VSymposium18th International Neuroscience Winter ConferenceSölden, Austria

Inventions / Licenses / Patents

Polyclonal Anti-Tbr1 AntibodiesUW Tech Transfer 73660Licensed to Chemicon / Millipore

Polyclonal Anti-Tbr2 AntibodiesUW Tech Transfer 73670Licensed to Chemicon / Millipore

ANTI-INFLAMMATORY COATINGS TO IMPROVE BIOCOMPATIBILITY OF NEUROLOGICAL IMPLANTSU.S. Provisional Application No. 62/582,126 filed in the United States Patent and Trademark Office on November 6, 2017 (MIT Ref. # 19323)

47