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A Development of Chimeric VEGFR2 TK Inhibitor Based on Two Ligand Conformers from PDB: 1Y6A Complex - Medicinal Chemistry Consequences of a TKs Analysis Lucia Lintnerová, a Melissa García-Caballero, b Fridrich Gregáň, c Milan Melicherčík, c Ana R. Quesada, b Juraj Dobiaš, a Ján Lác, d Marta Sališová, a and Andrej Boháč, a,d* a Comenius University, Faculty of Natural Sciences, Department of Organic Chemistry, Mlynská dolina 842 15, Bratislava, Slovakia, [email protected], phone: +421260296409, fax: +421260296337 b Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos, 29071-Málaga, Spain. Tel. 34(9)52137128, Fax. 34(9)52132000, [email protected] c Matej Bel University, Faculty of Natural Sciences, Department of Chemistry Tajovského 40, 974 01 Banská Bystrica, Slovakia, [email protected], [email protected] d Biomagi, Inc., Mamateyova 26, 851 04 Bratislava, Slovakia, phone: +421902522144 1

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Page 1: estranky.sk · Web viewc Matej Bel University, Faculty of Natural Sciences, Department of Chemistry Tajovského 40, 974 01 Banská Bystrica, Slovakia, fridrich.gregan@umb.sk, milan.melichercik@umb.sk

A Development of Chimeric VEGFR2 TK Inhibitor Based on Two

Ligand Conformers from PDB: 1Y6A Complex - Medicinal

Chemistry Consequences of a TKs Analysis

Lucia Lintnerová,a Melissa García-Caballero,b Fridrich Gregáň,c Milan Melicherčík,c Ana R.

Quesada,b Juraj Dobiaš,a Ján Lác,d Marta Sališová,a and Andrej Boháč,a,d*

a Comenius University, Faculty of Natural Sciences, Department of Organic Chemistry, Mlynská dolina 842 15,

Bratislava, Slovakia, [email protected], phone: +421260296409, fax: +421260296337b Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Campus de

Teatinos, 29071-Málaga, Spain. Tel. 34(9)52137128, Fax. 34(9)52132000, [email protected] Matej Bel University, Faculty of Natural Sciences, Department of Chemistry Tajovského 40, 974 01 Banská

Bystrica, Slovakia, [email protected], [email protected] Biomagi, Inc., Mamateyova 26, 851 04 Bratislava, Slovakia, phone: +421902522144

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Representative 1H and 13C NMR spectra possessing spectral maps

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