VX745 - SYNkinase · e-phb2 eph,'4 lck yes lyn erk7 k2a1 cdc7 cokl3 cdkl2 cdkli cdk1_4 nk2 jnr '...

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Melbourne • Shanghai • San Diego • Cambridge VX745 SYN-1123 F F S N N N O Cl Cl 5-(2,6-dichlorophenyl)-2-(2,4- difluorophenylthio)-6H-pyrimido[1,6- b]pyridazin-6-one CAS Registry No.: 209410-46-8 Smiles String: c1cc(c(c(c1)Cl)c2c3ccc(nn3cnc2=O)Sc4cc c(cc4F)F)Cl Molecular Weight: 436.26 Molecular Formula: C19H9Cl2F2N3OS Lot Number: Refer to vial 1H-NMR: Available on request HPLC (Purity): > 95.0% @ 254 nm ES-MS: Available on request Description: VX745 is a selective inhibitor of p38alpha with an IC50 of 10 nM. Biological Activity

Transcript of VX745 - SYNkinase · e-phb2 eph,'4 lck yes lyn erk7 k2a1 cdc7 cokl3 cdkl2 cdkli cdk1_4 nk2 jnr '...

Page 1: VX745 - SYNkinase · e-phb2 eph,'4 lck yes lyn erk7 k2a1 cdc7 cokl3 cdkl2 cdkli cdk1_4 nk2 jnr ' crk7 cok7 007 anpp ucy20 cdk5 hipk4 cgmc pctairei pctajre2 pctarea kit ml-k4 mlki

Melbourne • Shanghai • San Diego • Cambridge

VX745 SYN-1123

F

F

S NN N

OClCl

5-(2,6-dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one

CAS Registry No.: 209410-46-8

Smiles String:c1cc(c(c(c1)Cl)c2c3ccc(nn3cnc2=O)Sc4ccc(cc4F)F)Cl

Molecular Weight: 436.26

Molecular Formula: C19H9Cl2F2N3OS

Lot Number: Refer to vial

1H-NMR: Available on request

HPLC (Purity): > 95.0% @ 254 nm

ES-MS: Available on request

Description:

VX745 is a selective inhibitor of p38alpha with an IC50 of 10 nM.

Biological Activity

Page 2: VX745 - SYNkinase · e-phb2 eph,'4 lck yes lyn erk7 k2a1 cdc7 cokl3 cdkl2 cdkli cdk1_4 nk2 jnr ' crk7 cok7 007 anpp ucy20 cdk5 hipk4 cgmc pctairei pctajre2 pctarea kit ml-k4 mlki

Melbourne • Shanghai • San Diego • Cambridge

Kinome Mapping

Shipping and Storage Temperature

Shipping:Ambient

Storage:2 years -20C, Powder 1 month, -4C in DMSO, More than one month -80C in DMSO

Solubility

DMSO 15mg/mL, Ethanol <1mg/mL

Preparing Stock Solutions

Stock Solution(1ml DMSO) 1mM 10mM 20mM 50mM

Mass(mg) 0.4362 4.3626 8.7252 21.8130

Page 3: VX745 - SYNkinase · e-phb2 eph,'4 lck yes lyn erk7 k2a1 cdc7 cokl3 cdkl2 cdkli cdk1_4 nk2 jnr ' crk7 cok7 007 anpp ucy20 cdk5 hipk4 cgmc pctairei pctajre2 pctarea kit ml-k4 mlki

Melbourne • Shanghai • San Diego • Cambridge

References

1. Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. T.Hideshima, M. Akiyama, T. Hayashi, P. Richardson, R. Schlossman, D. Chauhan, K.C.Anderson. Blood. 101(2), 703-705 (2003).

Ordering Information

To order more of this or any other SYNkinase compound, go to synkinase.com, Call us Toll Free(US Only) at 1- 877-854-6273 or email [email protected].

Product Datasheet (Rev. 1.1)


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