Vol. 269, No. 41 The Journal of October 14, 1994

Biological Chemistry Copyright 0 1994 by the American Society for Biochemistry and Molecular Biology, Inc.

9650 Rockville Pike, Bethesda, MD 20814 U.S.A.

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CONTENTS*

MINIREVIEW

face. Joseph C. Loftus, Jeffrey W. Smith, and Mark H. Integrin-mediated cell adhesion: the extracellular

Ginsberg

COMMUNICATIONS

Nitric oxide reduces early growth response-1 gene

terferon-y and lipopolysaccharide. Scott A. Henderson, expression in rat lung macrophages treated with in-

Peter H. Lee, Ernest0 E. Aeberhard, John W. Adams, Louis J . Ignarro, William J . Murphy, and Michael I? Sherman

Activators of protein kinase C stimulate association

Habib, Roman Herrera, and Stuart J. Decker of Shc and the PEST tyrosine phosphatase. Tania

Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in re-

Lambert, Chris Bunch, Kirsten Barber, Warren s. Wade, sponse to Alzheimer’s AP peptide. Chi Zhang, Mary I?

Grant A. Kraft, and William L. Klein

Novel isoprenylated proteins identified by an ex- pression library screen. Brenda J . Biermann, Teresa A. Morehead, Scott E. Tate, Jeffrey R. Price, Stephen K. Ran- dall, and Dring N. Crowell

Resistance of HIV-1 reverse transcriptase against

amino-1”,2”-oxathiole-2”,2”-dioxide)l (TSAO) deriva- [2‘,5‘-bis-O-(tert-butyldimethylsilyl)-3’-spir0-5-(4”-

the p51 subunit. Heidi Jonckheere, Jean-Marc Taymans, tives is determined by the mutation G I U ’ ~ ~ + Lys on

Jan Desmyter, Erik De Clercq, and Jozef Anne Jan Balzarini, Sonsoles Velazquez, Maria-JosP Camarasa,

ARTICLES

Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution. Peter J . Condon and William E. Royer, JI:

Intracellular trapping of a cytoplasmic folding inter- mediate of the phage P22 tailspike using iodoacet- amide. Susan K. Sather and Jonathan King

Cloning and characterization of the human neutro- phil-activating peptide (ENA-78) gene. Ming-shi Chang, Jennifer McNinch, Rita Basu, and Scott Simonet

pyridoxal 5’-phosphate. Cystathionine P-synthase is Transsulfuration depends on heme in addition to

Jan I? Kraus a heme protein. Vladimir Kery, Gabriela Bukovska, and

Receptor binding and functional properties of chi- meric human follitropin prepared by an exchange between a small hydrophilic intercysteine loop of hu- man follitropin and human lutropin. James A. Dias, kiqiu Zhang, and Xunxian Liu

CRS5 encodes a metallothionein-like protein in Sac- charomyces cerevisiae. Valeria Cizewski Culotta, William R. Howard, and Xiu Fen Liu

pression of the hematopoietic stem cell antigen Ets-2 and c-Myb act independently in regulating ex-

CD34. Paola Melotti and Bruno Calabretta

Escherichia coli expresses a copper- and zinc-con-

win Fridovich taining superoxide dismutase. Ludmil T Benov and Ir-

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Modeling the bacterial protein toxin, pneumolysin, in its monomeric and oligomeric form. Peter J . Mor- gan, Stefan C. Hyman, Olwyn Byron, Peter W. Andrew, Timothy J . Mitchell, and Arthur J. Rowe

Sex- and tissue-specific Bkm(GATA)-binding protein

Renu Wadhwa, Sridevi Naidu, Raghavender Nagaraj, and in the germ cells of heterogametic sex. Lalji Singh,

Mala Ganesan

Thyroid hormone-dependent differential regulation of multiple arginase genes during amphibian meta- morphosis. Danielle Patterton and Yun-Bo Shi

Regulation of phospholipase C-p4 by ribonucleotides and the a subunit of G,. Chang- Won Lee, Kweon-Haeng Lee, Sang Bong Lee, Dongeun Park, and Sue Goo Rhee

Adipocyte lipid-binding protein complexed with

crystallographic studies. Judith M. LaLonde, Melanie arachidonic acid. Titration calorimetry and x-ray

A. Leuenson, Jeremy J . Roe, David A. Bernlohr, and Leon- ard J . Banaszak

isolated rat hepatocyte by a nontransportable deriv- Inhibition of macroautophagy and proteolysis in the

Lys-PAla. Giouanni Miotto, Rina Venerando, Oriano ative of the multiple antigen peptide Leu,-Lys,-Lys,-

Marin, Noris Siliprandi, and Glenn E. Mortimore

cDNA-derived primary structure of the 25-kDa sub-

Gary Greenburg and Giinter Blobel unit of canine microsomal signal peptidase complex.

Drosophila ribosomal protein S3 contains an activity that cleaves DNA at apurinic/apyrimidinic sites. David M. Wilson III, WalterA. Deutsch, and Mark R. Kelley

Determination of the amounts and oxidation states of hemoglobins M Boston and M Saskatoon in single erythrocytes by infrared microspectroscopy. Aichun Dong, Masako Nagai, Yoshimasa Yoneyama, and Winslow S. Caughey

Reconstitution of nuclear factor KB activation in- duced by tumor necrosis factor requires membrane- associated components. Comparison with pathway

M. Chaturvedi, Bryant G. Darnay, Henry Chan, Masahiro activated by ceramide. Shrikanth A. G. Reddy, Madan

Higuchi, and Bharat B. Aggarwal

Phorbol myristate acetate stimulates the formation of 5-0xo-6,8,11,14-eicosatetraenoic acid by human

Powell, Francine Gravelle, and Sylvie Gravel neutrophils by activating NADPH oxidase. William S.

Protein expression using cotranslational fusion and cleavage of ubiquitin. Mutagenesis of the glutathi- one-binding site of human Pi class glutathione S-transferase. Rohan T Baker, Stewart A. Smith, Robert Marano, Jeff McKee, and Philip G. Board

A novel G p mutant in a patient with Albright hered- itary osteodystrophy uncouples cell surface recep-

Alexander Miric, Donald Zimmerman, and Michael A. tors from adenylyl cyclase. William Iil Schwindinger,

Levine

Repression of transforming growth factor pl pro- moter by the adenovirus oncogene E1A. Identifica-

repression. Pran K. Datta and Srilata Bagchi tion of a unique GC-rich sequence as a target for E1A

*The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1994) J . Biol. Chem. 269, 777-785, and reprints may be obtained from the editorial office.

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Role of nucleotide excision repair in processing of 04-alkylthymines in human cells. Johanna C. Klein, Maria J. Bleeker, Harlof C. l? I? Roelen, Joseph A. Rafferty, Geoff l? Margison, Humphrey I? Brugghe, Hans uan den Elst, Gijs A. van der Marel, Jacques H. uan Boom, Erik Kriek, and Anton J. M. Berns

Inactivation of human anaphylatoxin C5a and C5a des-Arg through cleavage by the plasminogen activa- tor activity of a human fibrosarcoma cell line. Abd Al-Roof Higazi and Iyad I. Barghouti

Rabbit skeletal muscle glycogen synthase expressed in COS cells. Identification of regulatory phosphoryl-

J. Roach ation sites. Alexander V Skurat, Yuhuan Wang, and Peter

Mutagenesis of cysteine residues in the human gona- dotropin a subunit. Roles of individual disulfide bonds in secretion, assembly, and biologic activity. Madoka Furuhashi, Hisao Ando, Malgorzata Bielinska, Mary R. Pixley, Toshihiko Shikone, Aaron J. W. Hsueh, and Irving Boime

Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis. Arne Slungaard and Nigel S. Key

Zinc(I1) and copper(I1) binding to serum albumin. A comparative study of dog, bovine, and human albu- min. James Masuoka and Paul Saltman

Myosin heavy chain synthesis is independently regu- lated in hypertrophy and atrophy of isolated adult

Laura C. Andersen, and John J. LaPres cardiac myocytes. William A. Clark, Steven J. Rudnick,

Delayed “all-or-none” activation of inositol 1,4,5- trisphosphate-dependent calcium signaling in single

James W. Putney, Jr. rat hepatocytes. Carlo Chiauaroli, Gary St. J. Bird, and

A9 Acyl-lipid desaturases of cyanobacteria. Molecu- lar cloning and substrate specificities in terms of fatty acids, sn-positions, and polar head groups. Toshio Sakamoto, Hajime Wada, Ikuo Nishida, Masayuki Ohmori, and Norio Murata

Opposite directed currents induced by the transport of dibasic and neutral amino acids in Xenopus oo- cytes expressing the protein rBAT. Andreas E. Busch, Tobias Herzer, Siegfried Waldegger, Friederike Schmidt, Manuel Palacin, Jiirg Biber, Daniel Markouich, Heini Murer, and Florian Lang

Actobindin binds with high affinity to a covalently

Lewis, and Edward D. Korn cross-linked actin dimer. Michael R. Bubb, Marc S.

Actobindin induces the accumulation of actin dimers that neither nucleate polymerization nor self-associ- ate. Michael R. Bubb, Jay R. Knutson, Denise K. Porter, and Edward D. Korn

The histidine interruption of an a-helical coiled coil allosterically mediates a pH-dependent ligand disso- ciation from macrophage scavenger receptors. Take- fumi Doi, Masahiro Kurasawa, Ken-ichi Higashino,

kahashi, Yoshiki Kawabe, Yoichiro Wada, Akiyo Matsumoto, Takeshi Zmanishi, Takashi Mori, Makoto Naito, Kiyoshi Ta-

and Tatsuhiko Kodama

Hormonal and environmental responsiveness of a de- velopmentally regulated protein repair L-isoaspartyl methyltransferase in wheat. Mary Beth Mudgett and Steven Clarke

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Synergistic activation of the type I adenylyl cyclase by Caa+ and G,-coupled receptors in vivo. Gary A. Way- man, Soren Impey, Zhiliang Wu, Wayne Kindsuogel, Lisa Prichard, and Daniel R. Storm

ATP-induced unspecific channel in yeast mitochon-

and Michel Rigoulet dria. Bernard Gue‘rin, Odile Bunoust, Valerie Rouqueys,

Molecular cloning and structural analysis of the hu- man gene encoding cellular retinaldehyde-binding protein. Richard Intres, Steven Goldflam, Jeffry R. Cook, and John W. Crabb

Geometry of the process of transcription activation at the u54-dependent nifH promoter of Kkbsiella pneunwniae. Jose‘ A. Molina-Lcjpez, Fernando Gouantes, and Eduardo Santero

The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate

son, Maribeth V Eiden, and Carolyn A. Wilson transporter. Zoltan Olah, Csaba Lehel, Wayne B. Ander-

Modulation of the activity of mitochondrial aspar- tate aminotransferase H362C by the redox state of the engineered interdomain disulfide bond. Peng Pan, Claude A. Jakob, Erika Sandmeier, Philipp Christen, and Heinz Gehring

Cell cycle-dependent modulation of a-interferon-in- ducible gene expression and activation of signaling components in Daudi cells. Rakesh Kumar, Laxminaray- ana Korutla, and Kerong Zhang

ATP-dependent arsenite transport in everted mem- brane vesicles of Escherichia coli. Saibal Dey, Dexian Dou, and Barry l? Rosen

A novel GTP-binding protein which is selectively re- pressed in SV40 transformed fibroblasts. Thomas Schenker, Christian Lach, Benedikt Kessler, Siluio Calder- ara, and Beat Dueb

Expression of gelatinase A, a mediator of extracellu- lar matrix remodeling, by tracheal gland serous cells in culture and in vivo. Jean-Marie Tournier, Miriam Po- lette, Jocelyne Hinnrasky, James Beck, Zena Werb, and Carol Basbaum

Exciton splitting in phycoerythrin 545. Robert Mac- Coll, Irene Lam, Carol Y Choi, and Jeanette Kim

A surface loop covering the active site of human pan- creatic lipase influences interfacial activation and lipid binding. Martha L. Jennens and Mark E. Lowe

The a3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes. Jean- Claude Monboisse, Roselyne Garnotel, Georges Bellon, No- buko Ohno, Corinne Perreau, Jacques l? Borel, and Nicho- las A. Kefalides

L-type voltage-sensitive calcium channel activation

tor-dependent pathway. Raui I! Misra, Azad Bonni, stimulates gene expression by a serum response fac-

Michael E. Greenberg Cindy K. Miranti, Victor M. Riuera, Morgan Sheng, and

Membrane binding properties of the factor M y-car- boxyglutamic acid-rich domain prepared by chemi- cal synthesis. Margaret Jacobs, Steven J. Freedman, Bar- bara C. Furie, and Bruce Furie

Control of glucose utilization in working perfused rat heart. Yoshishiro Kashiwaya, Kiyotaka Sato, Naotaka

and Janet V Passonneau Buchiya, Simon Thomas, David A. Fell, Richard L. Veech,

The insulin and C A M P response elements of the pro- lactin gene are overlapping sequences. Kirsten K. Ja- cob and Frederick M. Stanley

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Rockville Pike, Bethesda, MD 20814. Volume 269 for 1994: Institutions: United States, $790; Foreign, $980. StudentslPostdoctoral Fellows: United The Journal ofBiologicu1 Chemistry (ISSN 0021-9258) is published weekly by the American Society for Biochemistry and Molecular Biology, Inc., 9650

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JOURNAL OF BIOLOGICAL CHEMISTRY at P.O. Box 3000, Denville, NJ 07834, U.S.A.

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Structural and functional analysis of the NF"& p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an a-helical con- formation. M. Lienhard Schmitz, Marcos A. dos Santos Silva, Herbert Altmann, Michael Czisch, Tad A. Holak, and Patrick A. Baeuerle

Metal oxyanion stabilization of the rat glucocorti-

ress, Alice H. Cauanaugh, Pradip K. Chakraborti, and S. coid receptor is independent of thiols. Kevin J . Modar-

Stoney Simons, Jr:

The glucocorticoid receptor functions at multiple steps during transcription initiation by RNA polym- erase 11. Iain J. McEwan, Tova AlmloL Ann-Charlotte

and Jan-Ake Gustafsson Wikstrom, Karin Dahlman-Wright, Anthony l? H. Wright,

The topology of the S protein in the yeast-derived hepatitis B surface antigen particles. Nathalie Son- ueaux, Karel Conrath, Carine Capiau, Robert Brasseur, Erik Goormaghtigh, and Jean-Marie Ruysschaert

Placenta growth factor. Potentiation of vascular en- dothelial growth factor bioactivity, in vitro and in

Flk-lKDR. John E. Park, Helen H. Chen, Jane Winer, uiuo, and high affinity binding to Flt-1 but not to

Keith A. Houck, and Napoleone Ferrara

Induction of translation by the 5"untranslated re- gion of human androgen receptor mRNA. Atsushi Mizokami and Chawnshang Chang

The Saccharomyces cereuisiae copper transport pro- tein (Ctrlp). Biochemical characterization, regula- tion by copper, and physiologic role in copper up- take. Andrew Dancis, David Haile, Daniel s. Yuan, and Richard D. Hausner

Regions involved in binding of urokinase-type-1 in- hibitor complex and pro-urokinase to the endocytic a,-macroglobulin receptorflow density lipoprotein receptor-related protein. Evidence that the uroki- nase receptor protects pro-urokinase against bind-

Kjdler, Robert L. Cohen, David A. Lawrence, Beth Ann ing to the endocytic receptor. Anders Nykjrer, Lars

eueld, J ~ g e n Gliemann, and Peter A. Andreasen Garni-Wagner, Robert I? Todd III, AntomJan van Zonn-

Molecular cloning and chromosome localization of a putative basolateral Na+-K+-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. Eric Delpire, Michael I. Rauchman, David R. Beier, Steven C. Hebert, and Steven R. Gullans

Roles for both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase 11. Siyuan Tan, Teijiro Aso, Ronald C. Conaway, and Joan Weliky Conaway

Overlapping transcription by RNA polymerases I1

Ernest Martinez, Giorgio Lagna, and Robert G. Roeder and I11 of the Xenopus TFIIIA gene in somatic cells.

kinase ( M A P K K ) and its mutants in MH 3T3 cells. Overexpression of mitogen-activated protein kinase

Evidence that MAPKK involvement in cellular pro- liferation is regulated by phosphorylation of serine residues in its kinase subdomains VI1 and VIII. Rony Seger, Dalia Seger, Alfred A. Reszka, Erlynda S. Munar, Hagit Eldar-Finkelman, Grazyna Dobrowolska, Amy M. Jensen, Jean S. Campbell, Edmond H. Fischer, and Edwin G. Krebs

Intracellular turnover of cystic fibrosis transmem- brane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant pro- teins. Cristina L. Ward and Ron R. Kopito

Dictyostelium discoideum. A complex population of Characterization of lysosomal membrane proteins of

acidic integral membrane glycoproteins, Rab GTP- binding proteins and vacuolar ATPase subunits. Lesly Temesvari, Juan Rodriguez-Paris, John Bush, Theodore L. Steck, and James Cardelli

Characterization of a silencer regulatory element in the human interferon-y promoter. Jianping Ye, Pari- tosh Ghosh, Marc0 Cippitelli, J e f f Subleski, Kenneth J . Hardy, John R. Ortaldo, and Howard A. Young

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Potentiation of insulin stimulation of phosphatidyl- inositol 3-kinase by thiazolidinedione-derived an- tidiabetic agents in Chinese hamster ovary cells ex- pressing human insulin receptors and L6 myotubes. Bei Zhang, Deborah Szalkowski, Elva Diaz, Nancy Hayes, Roy Smith, and Joel Berger

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast

Hideaki Nagase cultures. John L. Fowlkes, Jan J. Enghild, KO Suzuki, and

Native cartilage matrix protein (CMP). Acompact tri-

Nik Hauser and Mats Paulsson mer of subunits assembled via a coiled-coil a-helix.

characterization of two new members of the porin Porins from plants. Molecular cloning and functional

Bettina Arbinger, Danja Schiinemann, Sieglinde Borchert, family. Karsten Fischer, Andreas Weber, Susanne Brink,

Hans W. Heldt, Birgit Popp, Roland Benz, Thomas A. Link, Christoph Eckerskorn, and Ulf-Ingo Flugge

Insulin-like growth factor-I increases expression of the porcine P-450 cholesterol side chain cleavage gene through a GC-rich domain. Randall J . Urban, Margaret A. Shupnik, and Yvonne H. Bodenburg

Pure and functionally homogeneous recombinant retinoid X receptor. Zhi-Ping Chen, Lirim Shemshedini, Beatrice Durand, Noa Nay, Pierre Chambon, and Hinrich Gronemeyer

Immunoaffinity purification of y-aminobutyric acid, (GABA,) receptors containing ypubunits. Evidence for the presence of a single type of y-subunit in GAEiA, receptors. Birgit Mossier, Martin Togel, Karoline Fuchs, and Werner Sieghart

Purification and characterization of Ag,Zn-superox-

posed to silver. Maria R. Ciriolo, Patrizia Civitareale, M. ide dismutase from Saccharomyces cereuisiae ex-

Giuseppe Rotilio Teresa Carr, Angel0 De Martino, Francesca Galiazzo, and

Inhibition of protein synthesis in insect cells by baculovirus-expressed heme-regulated eIF-2a ki- nase. Peter J . Chefalo, Jane M. Yang, Kolluru V: A. Ra- maiah, Lee Gehrke, and Jane-Jane Chen

Regulation of tissue-specific expression of alterna- tive peripheral myelin protein-22 (PMPZZ) gene tran- scripts by two promoters. Ueli Suter, G. Jackson Snipes, Raymond Schoener-Scott, Andrew A. Welcher, Sangeeta Pa- reek, James R. Lupski, Richard A. Murphy, Eric M. Shooter, and Pragna I . Pate1

Role of a 50-57-kDa polypeptide heterodimer in the

Xiao-Song Xie, Bill l? Crider, Yong-Ming Ma, and Dennis K. function of the clathrin-coated vesicle proton pump.

Stone

tides to class I major histocompatibility complex Phosphatase inhibitors block in vivo binding of pep-

Salter molecules. Matthew Tector, Qing Zhang, and Russell D.

A novel M, muscarinic acetylcholine receptor is ex- pressed in chick atrium and ventricle. Albert P Gad- but and Jonas B. Galper

Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic param- eters using the purified, secreted soluble protease expressed by a recombinant baculovirus. Deborah A. Brauo, Julja B. Gleason, Rosa I. Sanchez, Richard A. Roth, and Robert S. Fuller

A membrane-mediated catalytic event in prothrom- bin activation. Chun Kung, Eric Hayes, and Kenneth G. Mann

Hydrolytic inactivation of a breast carcinoma cell- derived serpin by human stromelysin-3. Duanqing Pei, Gopa Majmudar, and Stephen J. Weiss

In vitro and in uiuo comparison of hammerhead, hair- pin, and hepatitis delta virus self-processing ri- bozyme cassettes. Bharat M. Chowrira, Pamela A. Pauco, and James A. McSwiggen

vii

25916 Structural features of the em-KAprecursor required for posttranslational synthesis of deoxyhypusine. Young Ae Joe and Myung Hee Park

25922 Structure-specific cleavage of the RNA primer from

Huang, Yong Kim, John J. lhrchi, and Robert A. Bambara Okazaki fragments by calf thymus RNase HI. Lin

25928 Cloning, sequencing, and expression of R e d pro- teins from three distantly related thermophilic eu- bacteria. James G. Wetmur, Daphne M. Wong, Benjamin Ortiz, Jie Tong, Frederick Reichert, and David H. Gelfand

25936 Two distinct class A helix-loophelix transcription factors, E2A and BETA1, form separate DNA binding

Larry Gene Moss, and Ming-Jer B a i complexes on the insulin gene E box. Michael Peyton,

ADDITIONS AND CORRECTIONS 25942 Stereospecificity of sphingosine-induced intracellu-

lar calcium mobilization and cellular proliferation. Vol. 269 (1994) 17924-17930. Ana Olivera, Hong Zhang, Robert 0. Carlson, Mark E. Mattie, Richard R. Schmidt, and Sarah Spiegel

25942 Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

pen, Bart Goldhoorn, Conny Bakker, Ronald I? J . Oude Vol. 269 (1994) 17960-17964. Piter J. Bosma, Jurgen Sep-

Elferink, Jayanta Roy Chowdhury, Namita Roy Chowdhury, and Peter L. M. Jansen

25865 Hyperosmotic urea increases transcription and syn- thesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells. David M. Cohen, William W. Chin, and Steven R. Gullans

25871 Acetyl-coA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn

Itoi, Rick Barr, and Amy Barr rabbit heart. Gary D. Lopaschuk, Lee A. Witters, Toshiyuki

25879 Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells. Jan Borkn, Sabina Rustaeus, and Sven-Olof Olofsson

25889 Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme. Alberto Puig and Hiram F: Gilbert

25897 Processing of procarboxypeptidase A and other zy- mogens in murine mast cells. Michael M. Dikov, Eric B. Springman, Suresh Yeola, and William E. Serafin

25905 Purification and characterization of the 26 S protea- some from spinach leaves. Koji Fujinami, Nobuyuki

Wolfgang Baumeister, Miyuki Miyawaki, Takahide Sato, Tanahashi, Keiji Tanaka, Akira Ichihara, Zdenka Cejka,

and Hiroki Nakagawa

25911 Activity of two-chain recombinant human cytomega- lovirus protease. Barry C. Holwerda, Arthur J . Wittwer, Kevin L. Dufin, Christine Smith, Mihaly l? Toth, Linda S. Carr, Roger C. Wiegand, and Martin L. Bryant

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The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

October 14, 1994

MINIREVIEW Integrin-mediated cell adhesion: the extracellular face. Joseph C. Loftus, Jeffrey W. Smith, and Mark H. Ginsberg

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Acetyl-coA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. Gary D. Lopaschuk, Lee A. Witters, lbshiyuki Itoi, Rick Barr, and Amy Barr

CELL BIOLOGY AND METABOLISM Nitric oxide reduces early growth response-1 gene expression in rat lung macrophages treated with in-

Peter H. Lee, Ernest0 E. Aeberhard, John W. Adams, Louis terferon-y and lipopolysaccharide. Scott A. Henderson,

J . Ignarro, William J . Murphy, and Michael P Sherman

Activators of protein kinase C stimulate association

Habib, Roman Herrera, and Stuart J. Decker of Shc and the PEST tyrosine phosphatase. Tania

Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in re- sponse to Alzheimer’s AP peptide. Chi Zhang, Mary I? Lambert, Chris Bunch, Kirsten Barber, Warren S. Wade, Grant A. Krafi, and William L. Klein

Novel isoprenylated proteins identified by an ex- pression library screen. Brenda J . Biermann, Teresa A. Morehead, Scott E. Tate, Jeffrey R. Price, Stephen K. Ran- dall, and Dring N. Crowell

CRS5 encodes a metallothionein-like protein in Sac-

R. Howard, and Xiu Fen Liu charomyces cereuisiae. Valeria Cizewski Culotta, William

Inhibition of macroautophagy and proteolysis in the isolated rat hepatocyte by a nontransportable deriv-

Lys-PAla. Giovanni Miotto, Rina Venerando, Oriano ative of the multiple antigen peptide Leu,-Lys,-Lys,-

Marin, Noris Siliprandi, and Glenn E. Mortimore

Reconstitution of nuclear factor KB activation in-

associated components. Comparison with pathway duced by tumor necrosis factor requires membrane-

M. Chaturvedi, Bryant G. Darnay, Henry Chan, Masahiro activated by ceramide. Shrikanth A. G. Reddy, Madan

Higuchi, and Bharat B. Aggarwal

Phorbol myristate acetate stimulates the formation of S-0xo-6,8,11,14-eicosatetraenoic acid by human neutrophils by activating NADPH oxidase. William S. Powell, Francine Gravelle, and Sylvie Gravel

Expression of gelatinase A, a mediator of extracellu- lar matrix remodeling, by tracheal gland serous cells in culture and in uiuo. Jean-Marie Tournier, Miriam Po- lette, Jocelyne Hinnrasky, James Beck, Zena Werb, and Carol Basbaum

The a3 chain of type TV collagen prevents activation of human polymorphonuclear leukocytes. Jean- Claude Monboisse, Roselyne Garnotel, Georges Bellon, No- buko Ohno, Corinne Perreau, Jacques P. Borel, and Nicho- las A. Kefalides

Control of glucose utilization in working perfused rat heart. Yoshishiro Kashiwaya, Kiyotaka Sato, Naotaka Tsuchiya, Simon Thomas, David A. Fell, Richard L. Veech, and Janet l? Passonneau

Myosin heavy chain synthesis is independently regu- lated in hypertrophy and atrophy of isolated adult

Laura C. Andersen, and John J. LaPres cardiac myocytes. William A. Clark, Steven J. Rudnick,

25570

25605

25646

25660

25668

25699

25710

25742

25761

25816

25823

25879

25936

25942

Delayed “all-or-none” activation of inositol 1,4,5- trisphosphate-dependent calcium signaling in single

James W. Putney, J r rat hepatocytes. Carlo Chiavaroli, Gary St. J. Bird, and

Hormonal and environmental responsiveness of a de- velopmentally regulated protein repair L-isoaspartyl methyltransferase in wheat. Mary Beth Mudgett and Steven Clarke

Placenta growth factor. Potentiation of vascular en- dothelial growth factor bioactivity, in vitro and in uiuo, and high affinity binding to Flt-1 but not to

Keith A. Houck, and Napoleone Ferrara Flk-l/KDR John E. Park, Helen H. Chen, Jane Winer,

tein (Ctrlp). Biochemical characterization, regula- The Saccharomyces cerevisiae copper transport pro-

tion by copper, and physiologic role in copper up-

Richard D. Klausner take. Andrew Dancis, David Haile, Daniel S. Yuan, and

Regions involved in binding of urokinase-type-1 in- hibitor complex and pro-urokinase to the endocytic a,-macroglobulin receptorflow density lipoprotein receptor-related protein. Evidence that the uroki- nase receptor protects pro-urokinase against bind-

Kjgller, Robert L. Cohen, David A. Lawrence, Beth Ann ing to the endocytic receptor. Anders Nykjzr, Lars

eveld, Jergen Gliemann, and Peter A. Andreasen Garni-Wagner, Robert I? Todd III, Anton-Jan van Zonn-

kinase (WKK) and its mutants in NIH 3T3 cells. Overexpression of mitogen-activated protein kinase

Evidence that WKK involvement in cellular pro- liferation is regulated by phosphorylation of serine residues in its kinase subdomains VI1 and VIII. Rony

Hagit Eldar-Finkelman, Grazyna Dobrowolska, Amy M. Seger, Dalia Seger, Alfred A. Reszka, Erlynda S. Munar,

Jensen, Jean S. Campbell, Edmond H. Fischer, and Edwin G. Krebs

Intracellular turnover of cystic fibrosis transmem- brane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant pro- teins. Cristina L. Ward and Ron R. Kopito

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast

Hideaki Nagase cultures. John L. Fowlkes, Jan J. Enghild, KO Suzuki, and

Insulin-like growth factor-I increases expression of the porcine P-450 cholesterol side chain cleavage

Margaret A. Shupnik, and Yvonne H. Bodenburg gene through a GC-rich domain. Randall J. Urban,

Phosphatase inhibitors block in uiuo binding of pep- tides to class I major histocompatibility complex molecules. Matthew Tector, Qing Zhang, and Russell D. Salter

A novel M, muscarinic acetylcholine receptor is ex- pressed in chick atrium and ventricle. Albert I? Gad- but and Jonas B. Galper

Studies on the assembly of apolipoprotein B-100- and

McA-RH7777 cells. Jan Bore‘n, Sabina Rustaeus, and B-48-containing very low density lipoproteins in

Sven-Olof Olofsson

Two distinct class A helix-loophelix transcription factors, E2A and BETA1, form separate DNA binding

Larry Gene Moss, and Ming-Jer Tsai complexes on the insulin gene E box. Michael Peyton,

lar calcium mobilization and cellular proliferation. Stereospecificity of sphingosine-induced intracellu-

Vol. 269 (1994) 17924-17930. Ana Olivera, Hang Zhang, Robert 0. Carlson, Mark E. Mattie, Richard R. Schmidt, and Sarah Spiegel

Indicates a Communication

vlll ...

ix

-25255

25283

25310

25335

25400

25432

25529

25534

25549

25576

25735

25830

25838

25849

25889

25897

ENZYMOLOGY Resistance of HIV-1 reverse transcriptase against [2’,5’-bis-0-(tert-butyldimethylsilyl~-3‘-spir0-6-~4- amino-1”,2”-oxathiole-2”,2”-dioxide)l (TSAO) deriva- tives is determined by the mutation GluISS -+ Lys on the p51 subunit. Heidi Jonckheere, Jean-Marc Taymans, Jan Balzarini, Sonsoles Velazquez, MariaJose‘ Camarasa, Jan Desmyter, Erik De Clercq, and Jozef Ann6

Transsulfuration depends on heme in addition to pyridoxal 5”phosphate. Cystathionine P-synthase is a heme protein. Vladimir Kery, Gabriela Bukovska, and Jan l? Kraus

Escherichia coli expresses a copper- and zinc-con- taining superoxide dismutase. Ludmil T Benov and Ir- win Fridovich

Regulation of phospholipase C-p4 by ribonucleotides and the a subunit of G,. Chang- Won Lee, Kweon-Haeng Lee, Sang Bong Lee, Dongeun Park, and Sue Goo Rhee

Synergistic activation of the type I adenylyl cyclase by Ca2+ and G,-coupled receptors in vivo. Gary A. Way- man, Soren Impey, Zhiliang Wu, Wayne Kindsvogel, Lisa Prichard, and Daniel R. Storm

Modulation of the activity of mitochondrial aspar- tate aminotransferase H352C by the redox state of the engineered interdomain disulfide bond. Peng Pan,

Heinz Gehring Claude A. Jakob, Erika Sandmeier, Philipp Christen, and

des-Arg through cleavage by the plasminogen activa- Inactivation of human anaphylatoxin C5a and C5a

tor activity of a human fibrosarcoma cell line. Abd Al-Roof Higazi and Iyad I. Barghouti

Rabbit skeletal muscle glycogen synthase expressed in COS cells. Identification of regulatory phosphoryl-

J. Roach ation sites. Alexander V. Skurat, Yuhuan Wang, and Peter

Platelet factor 4 stimulates thrombomodulin protein C-activating cofactor activity. A structure-function analysis. Arne Slungaard and Nigel S. Key

A9 Acyl-lipid desaturases of cyanobacteria. Molecu- lar cloning and substrate specificities in terms of fatty acids, sn-positions, and polar head groups.

Ohmori, and Norio Murata Toshio Sakamoto, Hajime Wada, Ikuo Nishida, Masayuki

Potentiation of insulin stimulation of phosphatidyl- inositol 3-kinase by thiazolidinedione-derived an-

pressing human insulin receptors and L6 myotubes. tidiabetic agents in Chinese hamster ovary cells ex-

Bei Zhang, Deborah Szalkowski, Elva Diaz, Nancy Hayes, Roy Smith, and Joel Berger

Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic param- eters using the purified, secreted soluble protease

Bravo, Julja B. Gleason, Rosa I. Sanchez, Richard A. Roth, expressed by a recombinant baculovirus. Deborah A.

and Robert S. Fuller

A membrane-mediated catalytic event in prothrom-

Mann bin activation. Chun Kung, Eric Hayes, and Kenneth G.

Hydrolytic inactivation of a breast carcinoma cell- derived serpin by human stromelysin-3. Duanqing Pei, Gopa Majmudar, and Stephen J. Weiss

Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme. Alberta Puig and Hiram I? Gilbert

Processing of procarboxypeptidase A and other zy- mogens in murine mast cells. Michael M. Dikov, Eric B. Springman, Suresh Yeola, and William E. Serafin

25905

25442

25581

25637

25677

25719

25754

25809

25277

25303

25321

25328

25354

25359

25381

25387

Purification and characterization of the 26 S protea- some from spinach leaves. Koji Fujinami, Nobuyuki Tanahashi, Keiji Tanaka, Akira Ichihara, Zdenka Cejka, Wolfgang Baumeister, Miyuki Miyawaki, Takahide Sato, and Hiroki Nakagawa

MEMBRANES AND BIOENERGETICS ATP-dependent arsenite transport in everted mem-

Dou, and Barry l? Rosen brane vesicles of Escherichia coli. Saibal Dey, Dexian

Opposite directed currents induced by the transport of dibasic and neutral amino acids in Xenopus oo- cytes expressing the protein rBAT. Andreas E. Busch, Tobias Herzer, Siegfried Waldegger, Friederike Schmidt, Manuel Palacin, Jiirg Biber, Daniel Markovich, Heini Murer, and Florian Lang

The topology of the S protein in the yeast-derived hepatitis B surface antigen particles. Nathalie Son-

Erik Goormaghtigh, and Jean-Marie Ruysschaert ueaux, Karel Conrath, Carine Capiau, Robert Brasseur,

Molecular cloning and chromosome localization of a putative basolateral Na+-K+-2Cl- cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells. Eric Delpire, Michael I. Rauchman, David R. Beier, Steven C. Hebert, and Steven R. Gullans

Characterization of lysosomal membrane proteins of Dictyostelium discoideum. A complex population of acidic integral membrane glycoproteins, Rab GTP- binding proteins and vacuolar ATPase subunits. Lesly Temesvari, Juan Rodriguez-Paris, John Bush, Theodore L. Steck, and James Cardelli

Porins from plants. Molecular cloning and functional characterization of two new members of the porin

Bettina Arbinger, Danja Schiinemann, Sieglinde Borchert, family. Karsten Fischer, Andreas Weber, Susanne Brink,

Hans W. Heldt, Birgit Popp, Roland Benz, Thomas A. Link, Christoph Eckerskorn, and Ulf-Ingo Fliigge

Role of a 50-57-kDa polypeptide heterodimer in the function of the clathrin-coated vesicle proton pump. Xiao-Song Xie, Bill l? Crider, Yong-Ming Ma, and Dennis K. Stone

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

Cloning and characterization of the human neutro- phil-activating peptide (ENA-78) gene. Ming-shi Chang, Jennifer McNinch, Rita Basu, and Scott Simonet

Ets-2 and c-Myb act independently in regulating ex- pression of the hematopoietic stem cell antigen CD34. Paola Melotti and Bruno Calabretta

Sex- and tissue-specific Bkm(GATA)-binding protein in the germ cells of heterogametic sex. Lalji Singh, Renu Wadhwa, Sridevi Naidu, Raghavender Nagaraj, and Mala Ganesan

Thyroid hormone-dependent differential regulation of multiple arginase genes during amphibian meta- morphosis. Danielle Patterton and Yun-Bo Shi

unit of canine microsomal signal peptidase complex. cDNA-derived primary structure of the 25-kDa sub-

Gary Greenburg and Giinter Blobel

Drosophila ribosomal protein 53 contains an activity

David M. Wilson III, Walter A. Deutsch, and Mark R. Kelley that cleaves DNA at apurinic/apyrimidinic sites.

Protein expression using cotranslational fusion and cleavage of ubiquitin. Mutagenesis of the glutathi- one-binding site of human Pi class glutathione S-transferase. Rohan T Baker, Stewart A. Smith, Robert Marano, Je f f McKee, and Philip G. Board

A novel G p mutant in a patient with Albright hered- itary osteodystrophy uncouples cell surface recep-

Alexander Miric, Donald Zimmerman, and Michael A. tors from adenylyl cyclase. William I? Schwindinger,

Levine

Indicates a Communication

X

25392

25406

25411

25419

25437

25447

25483

25515

25521

25543

25613

25629

25655

25684

25692

25728

25770

Repression of transforming growth factor p l pro-

tion of a unique GC-rich sequence as a target for E1A moter by the adenovirus oncogene E l k Identifica-

repression. Pran K. Datta and Srilata Bagchi

ATP-induced unspecific channel in yeast mitochon-

and Michel Rigoulet dria. Bernard Gue'rin, Odile Bunoust, Vale'rie Rouqueys,

Molecular cloning and structural analysis of the hu- man gene encoding cellular retinaldehyde-binding

and John W. Crabb protein. Richard Intres, Steven Goldflam, Jeffry R. Cook,

at the a54-dependent nifH promoter of Klebsiella Geometry of the process of transcription activation

pneumoniae. Jose A. Molina-Upez, Fernando Govantes, and Eduardo Santero

Cell cycle-dependent modulation of a-interferon-in- ducible gene expression and activation of signaling

ana Korutla, and Kerong Zhang components in Daudi cells. Rakesh Kumar, Laxminaray-

A novel GTP-binding protein which is selectively re- pressed in SV40 transformed fibroblasts. Thomas Schenker, Christian Luch, Benedikt Kessler, Silvio Calder- ara, and Beat Dueb

L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response fac- tor-dependent pathway. Ravi E! Misra, h a d Bonni, Cindy K. Miranti, Victor M. Rivera, Morgan Sheng, and Michael E. Greenberg

The insulin and CAMP response elements of the pro-

cob and Frederick M. Stanley lactin gene are overlapping sequences. Kirsten K. Ja-

Role of nucleotide excision repair in processing of 04-alkylthymines in human cells. Johanna C. Klein, Maria J . Bleeker, Harlof C. E! l? Roelen, Joseph A. Rafferty,

Elst, Gijs A. van der Marel, Jacques H. van Boom, Erik Geoff E! Margison, Humphrey l? Brugghe, Hans van den

Kriek, and Anton J. M. Berns

Mutagenesis of cysteine residues in the human gona- dotropin a subunit. Roles of individual disulfide bonds in secretion, assembly, and biologic activity. Madoka Furuhashi, Hisao Ando, Malgorzata Bielinska, Mary R. Pixley, Toshihiko Shikone, Aaron J . W. Hsueh, and Irving Boime

Structural and functional analysis of the NF-KB p65 C terminus. An acidic and modular transactivation

formation. M. Lienhard Schmitz, Marcos A. dos Santos domain with the potential to adopt an a-helical con-

Patrick A. Baeuerle Silva, Herbert Altmann, Michael Czisch, Tad A. Holak, and

The glucocorticoid receptor functions at multiple steps during transcription initiation by RNA polym- erase 11. Iain J. McEwan, Tova Almlofi Ann-Charlotte Wikstrom, Karin Dahlman-Wright, Anthony E! H. Wright, and Jan-Ake Gustafsson

Induction of translation by the 6'-untranslated re- gion of human androgen receptor mRNk Atsushi Mizokami and Chawnshang Chang

Roles for both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase 11. Siyuan Tan, nij iro Aso, Ronald C. Conaway, and Joan Weliky Conaway

Overlapping transcription by RNA polymerases I1 and I11 of the Xenopus TFIIIA gene in somatic cells. Ernest Martinez, Giorgio Lagna, and Robert G. Roeder

Characterization of a silencer regulatory element in the human interferon-y promoter. Jianping Ye, Pari-

Hardy, John R. Ortaldo, and Howard A. Young tosh Ghosh, Marc0 Cippitelli, J e f f Subleski, Kenneth J .

Pure and functionally homogeneous recombinant retinoid X receptor. Zhi-Ping Chen, Lirim Shemshedini, Beatrice Durand, Noa Noy, Pierre Chambon, and Hinrich Gronemeyer

25788

25795

25856

25865

25922

25928

25942

25259

25268

25289

25315

25339

25365

25426

25465

25470

25494

25557

Inhibition of protein synthesis in insect cells by baculovirus-expressed heme-regulated eIF-2a ki- nase. Peter J . Chefalo, Jane M. Yang, Kolluru V: A. Ra- maiah, Lee Gehrke, and Jane-Jane Chen

Regulation of tissue-specific expression of alterna- tive peripheral myelin protein-22 (PMP22) gene tran-

Raymond Schoener-Scott, Andrew A. Welcher, Sangeeta Pa- scripts by two promoters. Ueli Suter, G. Jackson Snipes,

reek, James R. Lupski, Richard A. Murphy, Eric M. Shooter, and Pragna I. Pate1

In vitro and in vivo comparison of hammerhead, hair- pin, and hepatitis delta virus self-processing ri- bozyme cassettes. Bharat M. Chowrira, Pamela A. Pauco, and James A. McSwiggen

Hyperosmotic urea increases transcription and syn- thesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells. David M. Cohen, William W. Chin, and Steven R. Gullans

Okazaki fragments by calf thymus RNase HI. Lin Structure-specific cleavage of the RNA primer from

Huang, Yong Kim, John J. nrchi, and Robert A. Bambara

teins from three distantly related thermophilic eu- Cloning, sequencing, and expression of Red pro-

bacteria. James G. Wetmur, Daphne M. Wong, Benjamin Ortiz, Jie Tong, Frederick Reichert, and David H. Gelfand

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. Vol. 269 (1994) 17960-17964. Piter J . Bosma, Jurgen Sep- pen, Bart Goldhoorn, Conny Bakker, Ronald E! J . Oude Elferink, Jayanta Roy Chowdhury, Namita Roy Chowdhury, and Peter L. M. Jansen

PROTEIN CHEMISTRY AND STRUCTURE Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution. Peter J. Condon and William E. Royer, Jr.

mediate of the phage P22 tailspike using iodoacet- Intracellular trapping of a cytoplasmic folding inter

amide. Susan K. Sather and Jonathan King

Receptor binding and functional properties of chi-

between a small hydrophilic intercysteine loop of hu- meric human follitropin prepared by an exchange

man follitropin and human lutropin. James A. Dias, Yiqiu Zhang, and Xunxian Liu

Modeling the bacterial protein toxin, pneumolysin,

gun, Stefan C. Hyman, Olwyn Byron, Peter W. Andrew, in its monomeric and oligomeric form. Peter J . Mor-

Emothy J. Mitchell, and Arthur J . Rowe

Adipocyte lipid-binding protein complexed with arachidonic acid. Titration calorimetry and x-ray crystallographic studies. Judith M. Luhnde, Melanie A. Levenson, Jeremy J . Roe, David A. Bernlohr, and Leon- ard J. Banaszak

Determination of the amounts and oxidation states of hemoglobins M Boston and M Saskatoon in single erythrocytes by infrared microspectroscopy. Aichun Dong, Masako Nagai, Yoshimasa Yoneyama, and Winslow S. Caughey

The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate

son, Maribeth I? Eiden, and Carolyn A. Wilson transporter. Zoltan Olah, Csaba Lehel, Wayne B. Ander-

Exciton splitting in phycoerythrin 545. Robert Mac- Call, Irene Lam, Carol E: Choi, and Jeanette Kim

A surface loop covering the active site of human pan- creatic lipase influences interfacial activation and lipid binding. Martha L. Jennens and Mark E. Lowe

Membrane binding properties of the factor IX "car- boxyglutamic acid-rich domain prepared by chemi- cal synthesis. Margaret Jacobs, Steven J . Freedman, Bar- bara C. Furie, and Bruce Furie

Zinc(II) and copper(I1) binding to serum albumin. A comparative study of dog, bovine, and human albu- min. James Masuoka and Paul Saltman

xi

25587 Actobindin binds with high affinity to a covalently

Lewis, and Edward D. Korn cross-linked actin dimer. Michael R. Bubb, Marc S.

25592 Actobindin induces the accumulation of actin dimers that neither nucleate polymerization nor self-associ-

Edward D. Korn ate. Michael R. Bubb, Jay R. Knutson, Denise K. Porter, and

25598 The histidine interruption of an a-helical coiled coil allosterically mediates a pH-dependent ligand disso-

fumi Doi, Masahiro Kurasawa, Ken-ichi Higashino, ciation from macrophage scavenger receptors. Take-

kahashi, Yoshiki Kawabe, Yoichiro Wada, Akiyo Matsumoto, Takeshi Imanishi, Takashi Mori, Makoto Naito, Kiyoshi Ta-

and Tatsuhiko Kodama

25621 Metal oxyanion stabilization of the rat glucocorti- coid receptor is independent of thiols. Kevin J . Modar-

Stoney Simons, Jr. ress, Alice H. Cauanaugh, Pradip K. Chakraborti, and S.

25747 Native cartilage matrix protein (CMP). Acompact tri- mer of subunits assembled via a coiled-coil a-helix. Nik Hauser and Mats Paulsson

25777 Immunoaffinity purification of y-aminobutyric acid,

for the presence of a single type of y-subunit in (GABA,) receptors containing y,-subunits. Evidence

Fuchs, and Werner Sieghart GABA, receptors. Birgit Mossier, Martin Tagel, Karoline

25783 Purification and characterization of Ag,Zn-superox- ide dismutase from Saccharomyces cerevisiae ex- posed to silver. Maria R. Ciriolo, Patrizia Ciuitareale, M. Teresa Carr, Angelo De Martino, Francesca Galiazzo, and Giuseppe Rotilio

25911 Activity of two-chain recombinant human cytomega- lovirus protease. Barry C. Holwerda, Arthur J. Wittwer, Kevin L. Duffin, Christine Smith, Mihaly V Toth, Linda S. Carr, Roger C. Wiegand, and Martin L. Bryant

25916 Structural features of the eIF-SA precursor required for posttranslational synthesis of deoxyhypusine. Young Ae Joe and Myung Hee Park

Adams, John W., 25239 Aeberhard, Ernesto E.,

Agganval, Bharat B., 25369 Almlof, Tova, 25629 Altmann, Herbert, 25613 Andersen, Laura C., 25562 Anderson, Wayne B., 25426 Ando, Hisao, 25543 Andreasen, Peter A,, 25668 Andrew, Peter W., 25315 Anne, Jozef, 25255 Arbinger, Bettina, 25754 Aso, Teijiro, 25684

Baeuerle, Patrick A,, 25613 Bagchi, Srilata, 25392 Baker, Rohan T., 25381

Balzarini, Jan, 25255 Bakker, Conny, 25942

Bambara, Robert A., 25922 Banaszak, Leonard J.,

Barber, Kirsten, 25247

Barr, Amy, 25871 Barghouti, Iyad I., 25529

Basbaum, Carol, 25454 Barr, Rick, 25871

Baumeister, Wolfgang, Basu, Rita, 25277

Beck, James, 25454 Beier, David R., 25677 Bellon, Georges, 25475 Benov, Ludmil T., 25310 Benz, Roland, 25754 Berger, Joel, 25735 Bernlohr, David A., 25339

Biber, Jurg, 25581 Berns, Anton J. M., 25521

Bielinska, Malgorzata,

Biermann, Brenda J., 25251 Bird, Gary St. J., 25570 Bleeker, Maria J., 25521 Blobel, Giinter, 25354 Board, Philip G., 25381 Bodenburg, Yvonne H.,

Boime, Irving, 25543 Bonni, h a d , 25483 Borchert, Sieglinde, 25754 Borel, Jacques P., 25475 Boren, Jan, 25879

25239

25339

25905

25543

25761

Bosma, Piter J., 25942 Brasseur, Robert, 25637 Bravo, Deborah A,, 25830 Brink, Susanne, 25754 Brugghe, Humphrey F.,

Bryant, Martin L., 25911 Bubb, Michael R., 25587,

Bukovska, Gabriela, 25283 Bunch, Chris, 25247 Bunoust, Odile, 25406 Busch, Andreas E., 25581 Bush, John, 25719 Byron, Olwyn, 25315

Calabretta, Bruno, 25303 Calderara, Silvio, 25447 Camarasa, Maria-Jose,

Campbell, Jean S., 25699 Capiau, Carine, 25637

Carlson, Robert O., 25942 Cardelli, James, 25719

Carr, M. Teresa, 25783 Carr, Linda S., 25911

Cavanaugh, Alice H., 25621 Caughey, Winslow S., 25365

Chakraborti, Pradiu K.. Cejka, Zdenka, 25905

25521

25592

25255

25621 - .

Chambon, Pierre, 25770 Chan, Henry, 25369 Chane. Chawnshane. 25655 Chang; Ming-shi, 2c277 Chaturvedi, Madan M.,

Chefalo, Peter J., 25788 Chen, Helen H., 25646 Chen, Jane-Jane, 25788

Chiavaroli, Carlo, 25570 Chen, Zhi-Ping, 25770

Chin, William W., 25865

Chowdhury, Jayanta Roy, Choi, Carol Y., 25465

Chowdhury, Namita Roy,

Chowrira, Bharat M., 25856 Christen, Philipp, 25432 Cippitelli, Marco, 25728 Ciriolo, Maria R., 25783 Civitareale, Patrizia, 25783 Clark, William A,, 25562

25369

25942

25942

AUTHOR INDEX

Clarke, Steven, 25605

Cohen, Robert L., 25668 Cohen, David M., 25865

Conaway, Joan Weliky,

Conaway, Ronald C., 25684 Condon, Peter J., 25259 Conrath, Karel, 25637 Cook, Jeffry R., 25411 Crabb, John W., 25411 Crider, Bill P., 25809 Crowell, Dring N., 25251 Culotta, Valeria Cizewski,

Czisch, Michael, 25613

Dahlman-Wright, Karin,

Dancis, Andrew, 25660 Darnay, Bryant G., 25369 Datta, Pran K., 25392 Decker, Stuart J., 25243 De Clercq, Erik, 25255 Delpire, Eric, 25677

Desmyter, Jan, 25255 De Martino, Angelo, 25783

Deutsch, Walter A,, 25359 Dey, Saibal, 25442

Diaz, Elva, 25735 Dias, James A,, 25289

Dobrowolska, Grazyna, Dikov, Michael M., 25897

Doi, Takefumi, 25598

dos Santos Silva, Marcos A., Dong, Aichun, 25365

Dou, Dexian, 25442

Durand, Beatrice, 25770 Duffh, Kevin L., 25911

Eckerskorn, Christoph,

Eiden, Maribeth V., 25426 Eldar-Finkelman, Hagit,

Elferink, Ronald P. J. Oude,

Enghild, J a n J., 25742

Fell, David A,, 25502 Ferrara, Napoleone, 25646 Fischer, Edmond H., 25699 Fischer, Karsten, 25754

25684

25295

25629

25699

25613

25754

25699

25942

Flugge, Ulf-Ingo, 25754 Fowlkes, John L., 25742 Freedman, Steven J., 25494 Fridovich, Irwin, 25310 Fuchs, Karoline, 25777 Fujinami, Koji, 25905 Fuller, Robert S., 25830 Furie, Barbara C., 25494 Furie, Bruce, 25494 Furuhashi, Madoka, 25543

Gadbut, Albert P., 25823 Galiazzo, Francesca, 25783 Galper, Jonas B., 25823 Ganesan, Mala, 25321 Garni-Wagner, Beth Ann,

Garnotel, Roselyne, 25475

Gehrke, Lee, 25788 Gehring, Heinz, 25432

Ghosh, Paritosh, 25728 Gelfand, David H., 25928

Ginsberg, Mark H., 25235 Gilbert, Hiram F., 25889

Gliemann, J ~ r g e n , 25668 Gleason, Julja B., 25830

Goldflam, Steven, 25411 Goldhoorn, Bart, 25942 Goormaghtigh, Erik, 25637 Govantes, Fernando, 25419 Gravel, Sylvie. 25373 Gravelle, Francine, 25373 Greenberg, Michael E.,

Gronemeyer, Hinrich, 25770 Greenburg, Gary, 25354

Gullans, Steven R., 25677, Guerin, Bernard, 25406

Gustafsson, J a n - h e , 25629

Habib, Tania, 25243 Haile, David, 25660 Hardy, Kenneth J., 25728 Hauser, Nik, 25747 Hayes, Eric, 25838 Hayes, Nancy, 25735

Heldt, Hans W., 25754 Hebert, Steven C., 25677

Herrera, Roman, 25243 Henderson, Scott A,, 25239

Higashino, Ken-ichi, 25598 Herzer, Tobias, 25581

Higazi, Abd Al-Roof, 25529

25668

25483

25865

Higuchi, Masahiro, 25369 Hinnrasky, Jocelyue, 25454 Holak, Tad A,, 25613

Houck, Keith A,, 25646 Holwerda, Barry C., 25911

Hsueh, Aaron J. W., 25543 Howard, William R., 25295

Huang, Lin, 25922 Hyman, Stefan C., 25315

Ichihara, Akira, 25905 Ignarro, Louis J., 25239 Imanishi, Takeshi, 25598 Impey, Soren, 25400 Intres, Richard, 25411 Itoi, Toshiyuki, 25871

Jacobs, Margaret, 25494 Jacob, Kirsten K., 25515

Jakob, Claude A., 25432 Jansen, Peter L. M., 25942 Jennens, Martha L., 25470 Jensen, Amy M., 25699 Joe, Young Ae, 25916 Jonckheere, Heidi, 25255

Kashiwaya, Yoshishiro,

Kawabe, Yoshiki, 25598 Kefalides, Nicholas A,,

25502

25475 Kelley, Mark R., 25359

Kessler, Benedikt, 25447 Kery, Vladimir, 25283

Key, Nigel S., 25549 Kim, Jeanette, 25465

Kindsvogel, Wayne, 25400 Kim, Yong, 25922

Kj~ller, Lars, 25668 King, Jonathan, 25268

Klein, Johanna C., 25521 Klausner, Richard D., 25660

Klein, William L., 25247 Knutson, Jay R., 25592 Kodama, Tatsuhiko, 25598 Kopito, Ron R., 25710 Korn, Edward D., 25587,

Korutla, Laxminarayana,

Krafft, Grant A,, 25247 Kraus, Jan P., 25283 Krebs, Edwin G., 25699 Kriek, Erik, 25521

25592

25437