Vol. 10 - Neuroscience Outlook

FACULTY UPDATES 2 MOVEMENT DISORDERS PROGRAM 8 PRESENTATIONS AND PUbLICATIONS 10

News aNd research from the departmeNts of Neurology aNd Neurosurgery

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outlook

VOL. 10 ISSUE 1} ++

Early treatment of craniosynostosisPatients can receive minimally invasive, endoscopic-assisted cranial vault remodeling to treat craniosynostosis at an early age

NeuroscIeNce

2 NEUROSCIENCE OUTLOOK Volume 10 | Issue 1

FROM THE CHAIRMEN

DEPARTMENT NEWS

Neuroscience Outlook, the Department of Neurosurgery newsletter, was initially launched in summer 2004. We are delighted to present an expanded version of Neuroscience Outlook in which the contri-butions of both the Neurosurgery and the Neurology departments are presented. This merger is a reflection of the close work-ing relationship that our two departments continue to share. In addition, the news-letter has undergone a makeover, which we hope you will enjoy. In this issue we feature news items from our departments, including the recent Advanced Comprehen-sive Stroke Center certification from The Joint Commission. This certification is the first in Georgia and only the second in the Southeast. We also focus on craniosynos-tosis and highlight the movement disorders program (the only center designated as a National Parkinson Disease Center of Excellence in Georgia or South Carolina). As always, we list the honors and awards as well as the presentations and publica-tions from our departments.

Cargill H. Alleyne Jr., M.D.Professor and Marshall Allen Distinguished Chair of [email protected]/neurosurgery

David Hess, M.D.Professor and Presidential Distinguished Chair of [email protected]/neurology

We’re GroWinGGeorgia Health Sciences University is now Georgia Regents UniversityThe Georgia Board of Regents recently voted to approve the consolida-tion of Augusta State University and Georgia Health Sciences University. The new name of our expanded institution is Georgia Regents University Augusta. The new university includes nine colleges: Medical College of Georgia; College of Dental Medicine; College of Graduate Studies; Col-lege of Nursing; College of Allied Health; College of Education; College of Science and Mathematics; College of Business; and College of Arts, Humanities, and Social Sciences.

The medical school class recently expanded to 230 students, making it the 6th largest medical school in the nation. With an expected economic impact of nearly $1.3 billion, the expanded university will have 10,000 students, more than 650 acres of campus, nearly 150 buildings, more than 1,000 full-time faculty, approximately 5,600 staff, an integrated health system, and an intercollegiate athletics program. The university’s clinical arm, Georgia Regents Health System, includes the 478-bed Medical Center and the 154-bed Children’s Hospital of Georgia (formerly Children’s Medical Center).

Neuroscience OutlookA publication of the Georgia Regents University Departments of Neurology and Neurosurgery

Editor-in-chief: Cargill H. Alleyne Jr., M.D.Editor: Phil MalkinsonIllustrations: Colby Polonsky, M.S.Contributors: Ian Heger, M.D., David C. Hess, M.D., Cargill H. Alleyne Jr., M.D., Kapil D. Sethi, M.D., F.R.C.P., John Morgan M.D., Ph.D., Shyamal Mehta M.D., Ph.D., Cole A. Giller, M.D., Ph.D., M.B.A., and Jill Trumble M.D.

Cargill H. Alleyne Jr., M.D.

David Hess, M.D.

Accomplishments And recognition

Cargill H. Alleyne Jr., M.D., (Department of Neuro-surgery) served as President of the Georgia Neurosurgical Society, May 2012 to present. He also continued his duties as Chair of the Neurology/Neurosurgery section of the National Medical Association

at its annual meeting in August 2012 in New Orleans, where he moderated the Don H. Wood, M.D., postgraduate resident forum, and the Clarence S. Greene, Sr., M.D., Stroke Symposium. In addition, he was listed as one of the Best Doctors in America in 2013. Finally, his educational children’s book “Ned’s Head” received an “Honorable mention” in the fall 2012 Royal Drag-onfly children’s book award competition.

Krishnan Dhandapani, M.D., (Department of Neurosurgery) was an ad hoc reviewer for the Veterans

Affairs (VA)—Neurobiology A (NURA) Study Panel, the

NIH Brain Injury and Neurovascular Pathologies (BINP) Study Section, and

the NIH, ZNS1 SRB-E (54) Special Emphasis Panel “Translational Research Review,” (U44 award mech-anism). In addition, he was a scientist reviewer for the United States Army Medi-cal Research and Materiel Command and a panelist at the Second Augusta Research Symposium on Advances in Warrior Care (Augusta Wounded Warriors Project).

FACULTY & STAFF UPDATES

3 Volume 10 | Issue 1 gru.edu/neuro

TOP HONORSNeurosurgeons Cargill H. Alleyne Jr., M.D., Cole Giller, M.D., Ph.D., M.B.A., and John Vender, M.D., were recognized as being among the Best Doctors in America for 2013. They have previously been cited for this honor. Neurologists David C. Hess, M.D., and Kapil D. Sethi, M.D., were included in a list of America’s Top Doctors and US News Top Doctors in 2012. All five physicians have previously received these awards.

TRANSITIONSWe are delighted to welcome Ian Heger, M.D., into the Department of Neurosurgery as Assistant Professor and section Chief of Pediatric Neurosurgery. Dr. Heger completed his medical training at SUNY Downstate in Brooklyn, N.Y., and his pediatric neurosurgery fellowship at the Children’s Hospital of Philadelphia. He held previ-ous positions at Wolfson’s Children’s Hospital in Jacksonville, Fla., and Joe DiMaggio Hospital in Miami. He has been named as one of America’s Top Surgeons in 2008, 2009, and 2012. Dr. Heger will work to expand the pediatric neurosurgical service at the Children’s Hospital of Georgia (formerly Children’s Medical Center), Georgia Regents University.

Cole A. Giller, M.D., Ph.D., M.B.A., (Department of Neurosurgery) was an ad hoc

reviewer for Neurosurgery. In July he was nominated to the medical advisory board

of the International Essential Tremor Foundation. In addition he was cited as one of the Best Doctors in America for 2013.

David C. Hess, M.D., (Department of Neurology) was cited as one of America’s Top Doctors in 2012 and was also named a US News Top Doctor. In addition, he won an Outstanding Faculty member

award and the Georgia Health Sciences Research Institute Distinguished Research Award in 2012.

Sergei A. Kirov, Ph.D., (Department of Neurosurgery)

was on an NIH Special Emphasis Panel (ZGM1 TWD-7 SC) Review of

SCORE Grant Applications in December 2012.

Lin Mei, Ph.D., (Department of Neurology) was awarded three grants. The first was an NIH R21 grant (NS078774, 8/1/2012–7/31/2014 with

co-investi-gator Darrell Brann, Ph.D.) entitled “Mechanisms of neuregulin

1 protection of excitatory neurons in stroke mod-els.” Its major goal is to study whether neuregulin 1 protects excitatory neurons in stroke indirectly by regu-lating GABAergic neurons. The second grant was a Muscular Dystrophy Asso-ciation grant (MDA240849, 8/1/2012–7/31/2015) entitled “Mechanisms of LRP4 autoantibodies in myasthenia gravis.” The major goal of this proposal

is to study pathogenic mechanisms of LRP4 autoantibodies in myasthenia gravis. The third grant was a VA grant (1/01IBX001020A, 7/1/2013–6/30/2017) entitled “Mechanisms of Erbin regulation of remyelination.” The goal of this grant is to investigate roles of Erbin in nerve regeneration and underlying mechanisms.

Kapil Sethi, M.B.B.S., (Department of Neurology) was named one of America’s Top Doctors and a

US News Top Doctor in 2012.

Jeffrey Switzer, D.O., (Department of Neurology)

was awarded an American Heart Associa-tion Southeast Affiliate Grant in Aid for

“Minocycline in acute intra-cerebral hemorrhage,” 2012–2014.

John Vender, M.D., (Department of Neurosurgery) was cited as one of the Best

Doctors in America for 2013.

Frederick Deutsch, M.D.Mr. & Mrs. Dale GodbyMr. Michael GoldsteinMrs. Diane Grimsley Elliott G. Gross, M.D.Mr. Fred HuntIntegrity MedicalJim and Janet IvettDr. Gregor W. JasonMs. Mary Losikoff

Mark Loomus, M.D.Dr. David LoringDr. Jose Maestre-MorenoDavid A. Nye, M.D.Ms. Gloria PittBridglal Ramkissoon, M.D.Mr. & Mrs. Asher RivnerMichael H. Rivner, M.D.The Rockwood TrustIgnacio Rodriguez, M.D.

THANKS TO OUR DONORSDonations received from January–June 2012

The Sanctuary of AugustaKapil D. Sethi, M.D., F.R.C.P.Saeed S. Shahidsalles,

M.D., Ph.D.Michael Stein, M.D. T. Rowe Price Associates,

Inc.Kenneth Vatz, M.D.Ms. Janet L. VoightDr. Michelle C. Winston

neurologyALS Association of Georgia Mark AntebiBaker and Baker FoundationDr. Christopher BrandonMrs. Eileen BrandonDr. David ButlerMr. & Mrs. John CisarDr. Barbara CohenThe Comfort Keepers 429

neurosurgeryMarshall B. Allen Jr., M.D. Cargill H. Alleyne, M.D. Haroon F. Choudhri, M.D. Dr. Ernest C. Fokes Jr. Marilyn E. Montgomery The Staulcup Foundation John R. Vender, M.D.


Artist’s depiction of unilateral coronal synostosis being treated via an endoscopic-assisted, minimally invasive orbital advancement technique. this pro-cedure has numerous advantages over the standard open procedure.

CLINICAL SPOTLIGHT


craniosynostosis is the premature fusion of one or more cranial sutures. It occurs in 1 out of 2,500 births and can present in an isolated fashion (non-syndromic) or associated with other congenital abnormalities (syndromic). Most commonly, the different types of synos-tosis present with an identifiable, reproducible pattern. The most common is sagittal synosto-sis, which has a slight male predominance. The typical pattern of the fused sagittal suture is elongation of the longitudinal axis and nar-rowing of the width of the head leading to what is termed a scaphocephalic shape (figure 1). Metopic synostosis has a slight female pre-dominance and is characterized by fusion of the metopic suture, which results in flattening and retrusion of the frontal bones and narrowing of the intracanthal distance (hypotelorism), leading to a triangular forehead shape or trigonecephaly (figure 2). Coronal synostosis leads to ipsilateral forehead flattening and elevation of the superior orbital rim along with contralateral frontal bone boss-ing (figure 3). These changes are also projected along the skull base and result in the nasal bridge deviating to the affected side and the tip of the nose projecting away. In more severe cases, the mandible deviates

away from the affected side. Lamdoidal synos-tosis results in flattening of the occipital bone, which is uncommon and needs to be differenti-ated from positional plagiocephaly.

TreaTmenT opTionsThe traditional treatment has been to allow the child to grow and build up a circulating blood volume so the child can safely withstand an operation to reconstruct the cranial vault and attendant blood loss. Essentially, these proce-dures involve degloving the skull so that multiple osteotomies can be made to remove the calvar-ium. The calvarium can then be reshaped and reconstructed in such a fashion as to aestheti-cally return the skull to a more normocephalic appearance as well as enlarge the cranial vault to allow more room for the growing skull. Although these procedures are quite successful, they are

associated with significant blood loss and a very large cranial scar. To circumvent these problems, minimally invasive techniques have recently been developed to perform these procedures through smaller incisions using endoscopic assistance (figure 4). Using these techniques has been shown to reduce transfusion rates, operating time, and hospi-tal length of stay.

Early treatment ofcraniosynostosis Patients can receive minimally invasive, endoscopic-assisted cranial vault remodeling to treat craniosynostosis at an early age

Figure 1. Scaphocephalic shape

Figure 2. trigonecephaly

Here at Georgia Regents, we

intend to study the neurobehav-

ioral effects of the minimally invasive craniosynostosis release surgery.

by ian heger, m.d.


idenTifying The opTimal age for TreaTmenTAlthough there are clear benefits from the minimally invasive, endoscopic-assisted cra-nial vault remodeling procedures, it is unclear whether or if there is any benefit to the devel-oping brain to have these procedures done at an early age. We do know that early operations can lead to less strabismus and astigmatism in patients with coronal synostosis. Additionally, it has been demonstrated that if the brain devel-ops under pressure, such as with untreated hydrocephalus, there is a negative impact on cognitive development. Although there has not been a clear demonstration in the literature that earlier treatment of craniosynostosis leads to an improved cognitive outcome, no studies have been undertaken in children undergo-ing minimally invasive, endoscopic-assisted cranial vault remodeling procedures. Here at Georgia Regents, we intend to study the neu-robehavioral effects of the minimally invasive craniosynostosis release surgery. Children will be evaluated before and after the surgery to see how the surgery affects their development as well as their mater-nal bonding so these questions can finally be answered.

To circumvent these problems, minimally invasive techniques have recently been developed to perform these procedures

through smaller incisions using endoscopic assistance

(figure 4). Using these techniques has been shown to reduce transfusion rates, operating time, and hospital

length of stay.

Figure 3. Elevation of the superior orbital rim along with contralateral frontal bone bossing

Figure 4. Minimally invasive techniques using endoscopic assistance

To speak with Ian Heger, M.D., or to

refer a patient, please email [email protected] or call 706.721.9386. To learn more about pediatric neurosur-gery at Georgia Regents Medical Center or Children’s Hospital of Georgia, visit gru.edu/neuro.

CLINICAL SPOTLIGHT


FACILITY SPOTLIGHT

the multidisciplinary stroke center at Georgia Regents Medical Center (GRMC) was awarded an Advanced Comprehensive Stroke Center designation after a rigorous two-day review in January by The Joint Commission on the Accreditation of Healthcare Organizations. The stroke center comprises stroke neurol-ogy, emergency medicine, neuroradiology, cerebrovascular and endovascular neurosur-gery, neurointensive care, nursing, pharmacy, physical therapy, occupational therapy, and speech therapy, among other disciplines. This makes our center the first in the state of Georgia, the second in the Southeast, and only the 16th in the entire nation to be given this highest designation of stroke care.

“This means we provide high-level care for patients with the most severe and challenging types of strokes and cerebrovascular disease, and we help set the national standards in highly-specialized stroke care,” says David S. Hefner, CEO of the medical center. “It’s not any one thing that we do here; it’s a myriad of best-practices performed by specially-trained staff from a variety of health care disciplines, all working together to provide better out-comes for our stroke patients.”

expanding CapabiliTiesDuring a rigorous two-day onsite review, Joint Commission experts examined the medical center’s compliance with Com-prehensive Stroke Center standards and requirements, including 24/7 availability of specialized treatments, staff who possess the unique education and competencies to care for complex stroke patients, and advanced imaging capabilities.

Georgia Regents Medical Center recently opened a second interventional radiology suite, enabling the hospital to treat more than one complex patient at a time. The state-of-the-art

biplanar angiography machines (Phillips Allura Xper model) produce clear 3-D pictures of the arteries in the brain and neck. Surveyors also looked at post-hospital care coordination for patients and patient-centered stroke research efforts. Physician scientists at GRMC are currently researching how stem cell ther-apy and insulin administration methods affect stroke recovery.

CollaboraTive CareComprehensive Stroke Center certification was developed in collabora-tion with the Brain Attack Coalition and the American Heart Association/American Stroke Association. The AHA/ASA awarded GRMC with its second consecutive Get With The Guidelines® Stroke Gold Plus Quality Achieve-ment Award in 2012, and the hospital was named to the AHA/ASA Target: Stroke Honor Roll for excellence in emergency stroke care in December.

GRMC is the only truly comprehensive stroke center in the region with the expertise and technical skills needed to offer 24/7 care for acute cerebrovascular events. For this reason, GRMC extends quality stroke care to rural patients throughout the region through REACH Health, Inc. This hub-and-spoke network allows stroke specialists at GRMC to diagnose and treat stroke patients remotely at more than a dozen rural hospitals and a few larger com-munity hospitals. GRMC also collaborates with neighboring EMS teams by providing pre-hospi-tal and interventional stroke care education.

Congratulations to the many individuals who prepared for our review, especially the Stroke Program Coordinator, Holly Hula, R.N., B.S.N., C.N.R.N.

If you have questions about the Stroke

Program, please visit us at gru.edu/stroke, call 706.721.4581 or email [email protected]. For more information on The Joint Commission and American Heart Association’s Advanced Certification for Compre-hensive Stroke Center, visit jointcommission.org or heart.org/myhospital.

Highest Designation JCAHO awards stroke center its highest designation— Advanced Comprehensive Stroke Center

the Phillips Allura Xper biplanar angiography suite produces clear 3-D pictures. It was the first in the South to feature VasoCt imaging that enables the hospital’s neurosurgery team to more precisely pinpoint and open blockages.


the movement disorders center at Georgia Regents Health System is focused on state-of-the-art, evidence-based interdisciplinary care for patients and families suffering with Par-kinson’s disease (PD) and related disorders such as tremor, dystonia, chorea, restless legs syndrome, gait and balance problems, and drug-induced movement disorders. Our

center is the only center designated as a National Parkinson Disease Center of Excellence in Georgia or South Carolina. Our physicians Kapil D. Sethi, M.D., FRCP,

John Morgan, M.D., Ph.D., Shyamal Mehta, M.D., Ph.D., and Jill Trumble, M.D., are board-certified neurologists with training and expertise in diagnosing and treating common and complex movement disorders. We offer cutting-edge medical therapies, including botulinum toxin ther-apy, for disorders characterized by excessive muscular activity.

We strongly believe in family-centered care and we work with the entire family to empower the patient and caregiver in making educated decisions regarding the choice of medical or surgical therapy. We achieve these goals with a strong interdisciplinary team consisting of a social worker, a neuropsychologist, nurses, and physical, occupational, and speech therapists in order to provide optimal care and educa-tional resources for patients and caregivers. We are intimately involved in outreach and have close working partnerships with support groups throughout Georgia and South Carolina. Communication with referring primary care physicians and neurologists is a priority, and as a result, patients are routinely sent to our center from all over Georgia, South Carolina, and beyond.

surgiCal TherapySurgery is a mainstay for the treatment of medication- resistant Parkinson’s disease, essential tremor, and other movement disorders, and we offer a full range of surgical options. Our experience with these operations began almost 30 years ago and our Deep Brain

Evidence-based care for movement disorders

by Kapil d. sethi, m.d., F.r.c.p., John morgan m.d., ph.d., shyamal mehta m.d., ph.d., cole giller, m.d., ph.d., m.B.A.,

and Jill trumble, m.d.

The interdisciplinary team at the Movement Disorders Center delivers evidence-based, family-centered care for patients and families with Parkinson’s disease and related disorders

Our center is the only center designated as a National Parkinson Disease Center of Excellence in Georgia or South Carolina.

Figure 1. Coronal MRI image showing DBS electrode inserted on left. the dark, rounded objects are the four electrical contacts

of the electrode and appear larger due to metal artifact.Figure 1. Coronal MRI image

CLINICAL & RESEARCH SPOTLIGHT


Stimulation (DBS) program has been active for almost two decades. These procedures have been shown to improve many of the disabling symptoms of movement disorders, as well as to increase the major quality of life indices. The neurosurgical team, led by Cole Giller, M.D., Ph.D., M.B.A., collaborates closely with the Movement Disorders Program physicians during patient selection and treatment. Pro-gramming of the DBS device is individualized, and can be done either by our physicians or the referring physician. We have performed more than 220 procedures for movement disorders in the past four years with excellent results and low morbidity.

researChWhile clinical care is our primary focus, we realize that basic and clinical research is the only way to identify disease-slowing therapies for these diseases in the future. Therefore, we are actively involved in clinical and basic research. The Movement Disorders Center has a long history of leading and participating in clinical research trials in Parkinson’s disease, restless legs syndrome, cervical dystonia, Huntington’s disease, and other movement disorders. We have received funding for con-ducting numerous clinical trials in PD from

prestigious funding sources such as the National Institutes of Health, the Parkinson Study Group, and the National Parkinson Foundation (NPF). We have studied or are currently studying drugs that attack PD on all fronts: drugs that may slow down disease progression, drugs that amelio-rate dyskinesias related to levodopa therapy, drugs that help treat neuropsychiatric and cognitive effects of the disease, and drugs that improve motor function.

Dr. Sethi has been involved in clinical trials in PD since the early 1990s, has designed national trials in PD, and has served on the steering com-mittees of important clinical trials of dopamine agonists and other therapeutics. He serves as the local Principal Investigator on the largest poten-tial disease-slowing trial in PD to date, looking at creatine versus placebo in PD (funded by NIH). Dr. Morgan has initiated numerous clinical trials in PD and serves as Co-Principal Investigator (with Tanya Simuni, M.D.) on a study of pioglita-zone in early PD to see if this medication actually has disease-slowing properties in PD. This study is funded by NIH and is a multi-center trial across the United States. We have been funded by NPF for multiple investigator-initiated studies (initiated by Dr. Nathan Herz, O.T.) in PD, including a study of occupational therapy in PD and a study of “Wiihab” with the Nintendo Wii in PD.

Figure 2. operative view of stereotactic frame holding guiding electrode through a bur hole to the chosen tar-get. Clear drapes facilitate neurologic monitoring of the patient.

Figure 3. lateral skull film showing DBS electrode. Note the four contacts at the tip of the electrode and the connection to the wire that will attach to the DBS generator.

The Georgia Regents Movement Disorders/

Parkinson’s Disease Center offers exceptional clinical diagnosis, treatment, and care for Parkinson’s disease and other move-ment disorders. If you have questions regarding movement disorders, please call 706. 721.2798 or email [email protected]. Refer a patient online at gru.edu/referral or call 706.721.4581.

Figure 2. operative view of stereotactic frame Figure 3. lateral skull film showing DBS electrode


PUBLICATIONS & PRESENTATIONS

presentAtions

Alleyne CHIntroduction to neurosurgery. Surgery 5000 lecture series, Medical College of Georgia, July 2012

Giller CNew and old aspects of deep brain stimulation for Parkinson’s disease.Augusta Parkinson’s Disease Support Group, Augusta, Ga., July 2012

Sukumari-Ramesh S, Alleyne Jr CH, Dhandapani KMAstrogliosis: a target for interven-tion in intracerebral hemorrhage? Translational Stroke Research 3:80-87, 2012

Kimbler DE, Shields J, Yanasak NE, Vender JR, Dhandapani KMActivation of P2X7 promotes cerebral edema and neurologi-cal injury after traumatic brain injury in mice. PLoS ONE, 7:e41229, 2012

Sukumari-Ramesh S, Alleyne Jr CH, Dhandapani KMAstrocyte-specific expression of survivin after intracerebral hemorrhage in mice: a possible role in reactive gliosis? J Neurotrauma 29:2798-2804, 2012

pUBlicAtions

Viers A, Allen MB, Alleyne CH Historical vignette: George Smith (1916-1964). J Neurosurg 117:800-803, 2012

Risher WC, Croom D, Kirov SA Persistent astroglial swelling accompanies rapid reversible dendritic injury during stroke-induced spreading depolarizations. Glia 60:1709-1720 [Epub ahead of print; (2012) Jul 20], 2012

Dreier JP, Isele T, Reif-furth C, Kirov SA, Dahlem M, Herreras O, for the COSBID study groupIs spreading depolarization characterized by an abrupt,

massive release of Gibbs free energy from the human brain cortex? Neuroscientist 19:25-42 [Epub ahead of print; (2012) Aug 20], 2013

Woodall MN, Alleyne CHNail gun head trauma: A comprehensive review of the literature. Journal of Trauma and Acute Care Surgery 73:993-6, 2012

Alleyne CHNed’s Head. North Charleston, SC, CreateSpace, 2012

Alleyne CHComment on Microsurgical anatomy of the carotid cave. Neurosurgery 70, ons311, 2012

Hester SM, Fisher JF, Lee MR, Macomson S, Vender JREvaluation of salvage tech-niques for infected baclofen pumps in pediatric patients with cerebral palsy. J Neurosurg Pediatr 10:548-54, 2012

Chutkan N, Tuttle JCervicothoracic fractures and dislocationsAnderson and Vaccaro, eds, Decision Making in Spinal Care, second ed, p55-58. Thieme, New York, 2012

Borlongan CV, Glover LE, Sanberg PR, Hess DCPermeating the blood brain barrier and abrogating the inflammation in stroke: impli-cations for stroke therapy. Curr Pharm 18:3670-6, 2012

Alleyne CH, Sukumari- Ramesh S, Dhandapani KMAstrocyte-specific expression of survivin mediates reactive gliosis after intracerebral hemorrhage. Congress of Neurological Surgeons Meeting, October 2012 (poster)

Giller C Surgery for Parkinson’s disease.Southeastern Parkinson’s Conference, Atlanta, Ga., October 2012

Alleyne CHComment on Use of a Yasargil mirror as an adjunct to indo-cyanine green angiography to evaluate the patency of elusive posterior communicating arteries during aneurysm clipping: case report. Neurosurgery 71:onsE197, 2012

Alleyne CH, Hughes DReview of Cavernous mal-formations of the nervous system. Neurology 79:1837, 2012

Zhang QG, Laird MD, Han D, Dhandapani KM, Brann DWCritical role of NADPH oxidase in neuronal oxidative damage and microglial activation fol-lowing traumatic brain injury. PLoS ONE 7:e34504, 2012

Alleyne CHSubarachnoid hemorrhage and unruptured intracranial aneurysms: diagnosis and management. Neurology Residents Noon Conference, Georgia Health Sciences University, September 2012

Alleyne CHCentral nervous system vascular malformations. University Hospital Noon Conference, Augusta, Ga., October 2012

Hess DCStem cells in stroke: Hype or hope. World Stroke Congress, Brasilia, Brazil, October 2012

Hess DCTelestroke in stroke systems of care. World Stroke Congress, Brasilia, Brazil, October 2012

Shields J, Dhandapani KMThe effect of traumatic brain injury on the circadian clock. Advances in Warrior Care Conference, Augusta, Ga., October 2012

Kirov SA, Sword JIn vivo 2-photon imaging of acute injury to synaptic cir-cuitry in the peri-contusional cortex. 8th Forum of European Neu-roscience, Barcelona, Spain, July 2012 (Abstract)

Alleyne CHSubarachnoid hemorrhage and unruptured intracranial aneurysms. National Medical Association Meeting, New Orleans. La., August 2012

July–December 2012

Names in blue indicate faculty members in the Georgia Regents university Neurosurgery or Neurology department.


Switzer JA, Rocker J, Mohorn P, Waller JL, Hughes D, Bruno A, Nichols FT, Hess DC, Natarajan K, Fagan SCClinical experience with three-factor prothrombin complex concentrate to reverse warfarin anticoagulation in intracranial hemorrhage. Stroke. 2012 Jul 17. [Epub ahead of print]PMID: 22811449

Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, Johnson MH, Hill WD, Ergul A, Fagan SC, Hess DCRemote ischemic precondition-ing is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012 Aug 21. [Epub ahead of print] PMID: 22910893

Switzer JA, Sikora A, Ergul A, Waller JL, Hess DC, Fagan SCMinocycline prevents IL-6 increase after acute ischemic stroke. Transl Stroke Res 3:363-368, 2012. Epub 2012 Mar 15

Meador KJ, Baker GA, Browning N, Cohen MJ, et alEffects of fetal antiepileptic drug exposure: outcomes at age 4.5 years. Neurology 78:1207-1214, 2012 Davis, KL, Murro, AM, Park, YD, Lee, GP, Cohen, MJ, Smith, JRPosterior quadrant epilepsy surgery: predictors of outcome. Seizure 21:722-728, 2012

Sethi KD, Mehta SHA clinical primer on restless legs syndrome: what we know, and what we don’t know. Am J Manag Care 18:S83-8, 2012

Chong RK, Lee KH, Morgan J, Mehta SH, Hall P, Sethi KDiagnostic value of the rapid assessment of postural insta-bility in Parkinson’s disease (RAPID) questionnaire. Int J Clin Pract66:718-21, 2012

Bruno A, Shah N, Akinwun-tan AE, Close B, Switzer JAStroke size correlates with functional outcome on the simplified modified rankin scale questionnaire. J Stroke Cerebrovasc Dis21:659-661, 2012

Switzer JA, Demaerschalk BMOvercoming challenges to sustain a telestroke network. J Stroke Cerebrovasc Dis21:535-40, 2012

Carroll JEHuman cord blood for neonatal brain damage. Ped Research 71:459-63, 2012

Akinwuntan AE, Devos H, Stepleman L, Casillas R, Rahn R, Smith S, Williams MPredictors of driving in

Sukumari Ramesh S, Alleyne CH, Vender JR, Dhandapani KMNrf2-ARE signaling augments glioma proliferation and chemoresistance.Society for Neuroscience Annual Meeting, New Orleans, La., October 2012

Kirov SAAstrocytes, microglia and neurons in early stroke and traumatic brain injury. University of Alabama at Birmingham Mini Symposium “Physiology and Pathophysiol-ogy of Astroglia,” Birmingham, Ala., October 2012

Giller CSome neurosurgical viewpoints of anesthesia for functional neurosurgery.Anesthesia Grand Rounds GHSU, November, 2012

Shakir B, Choudhri HFResection of alveolar soft part sarcoma.Georgia Neurosurgical Soci-ety Meeting, Atlanta, Ga., November 2012

Alleyne CHIntroduction to neurosurgery. Surgery 5000 lecture series, Medical College of Georgia, December 2012

individuals with relapsing- remitting multiple sclerosis. Mult Scler July 3, 2012 (Epub ahead of print)

Akinwuntan AE, O’Connor C, McGonegal E, Turchi K, Smith S, Williams M, Wachtel JPrediction of driving ability in people with relapsing- remitting multiple sclerosis using the stroke driver screening assessment. International Journal of MS Care 14:65-70, 2012

Choudhri HFNew strategies for spinal tumor surgery.Emirates Neuroscience Society Meeting, Dubai, UAE, November 2012

Dhandapani KMNeuro-immune interactions after TBI: a role in the develop-ment of cerebral edema. Department of Physiology, Georgia Health Sciences University, Augusta, Ga., November 2012

Dhandapani KMNeuro-immune interactions after TBI: a role in the develop-ment of cerebral edema. Brain and Behavior Discovery Institute, Georgia Health Sciences University, Augusta, Ga., December 2012

En bloc resection with recon-struction is important in the surgical management of certain spinal tumors. this illustration shows a large alveolar soft part sarcoma of the cervical-thoracic junction, which was resected in one piece with clean margins (Choudhri HF, New strategies for spinal tumor surgery).

CONFERENCE SCHEDULES

NON-PROFITUS POSTAGE

PAIDGEORGIA REGENTS

UNIVERSITY

GRU-001

Georgia Regents University1120 15th St., 1114Augusta, GA 30912

Jan. 3

All conferences are held from 8:00–9:00 am.

Dr. Ed Hartmann: Myasthenia Gravis

Jan. 10 Dr. Tom Swift: Case Presentation


Jan. 24 Dr. Shyamal Mehta: Deep Brain Stimulation, A Brave New World


Feb. 7 Dr. Anthony Murro: Epilepsy

Feb. 14 Dr. Tom Swift: Case Presentation

Feb. 21 Dr. Elizabeth Sekul: Child Neurology

Feb. 28 Dr. Askiel Bruno: Stroke

Mar. 7 Dr. Nancy McNair: VA General Neurology

Mar. 14 Dr. Tom Swift: Case Presentation

Mar. 21 TBA

Mar. 28 Dr. David Hess: Stroke

Apr. 4 Masters Week

Apr. 11 Dr. Tom Swift: Case Presentation

Apr. 18 Dr. John Morgan: Movement Disorders

Apr. 25 AAN Meeting

As a regional referral center for the South-

eastern U.S., the Georgia Regents Neuroscience Center of Excellence includes the area’s largest, most diverse team of adult and pediatric neurologists and neurosur-geons, including renowned experts in Parkinson’s disease, stroke, ALS, MS, functional and cerebrovas-cular neurosurgery, and complex spine surgery. To make an online referral, visit gru.edu/referral.

Neurosurgery Neurology

January–April 2013

AANS/CNS Section on Cerebrovascular Surgery, Feb. 3–6, Honolulu, Hawaii

International Stroke Conference, Feb. 6–8, Honolulu, Hawaii

Southern Neurosurgical Soci-ety, Feb. 20–23, Sarasota, Fla.

AANS/CNS Section on Disorders of the Spine & Peripheral Nerves, Mar. 6–9, Phoenix, Ariz.

American Academy of Neurol-ogy, Mar. 16–23, San Diego, Calif.

Comprehensive Stroke Management Update 2013, Apr. 6–8, Hilton Head, S.C.

Neurosurgical Society of Amer-ica, Apr. 7–10, Sea Island, Ga.

American Association of Neurological Surgeons, Apr. 27– May 1, New Orleans, La.

Upcoming meetings

Feb. 1 Evaluations

Feb.8

10:00–11:00 am Gamma Knife–Giller

11:00 am–noon Anatomy

noon–1:00 pm Case Conference

Feb. 15

10:00–11:00 am Radiology

11:00 am–noon Neuro 101


Feb. 22.

10:00–11:00 am Journal Club

11:00 am–noon Hours/Case Log Meeting

noon–1:00 pm M&M

Mar. 1

10:00–11:00 am Business–Giller

11:00 am–noon Oral Board


Mar. 8




Mar. 1511:00 am–noon Anatomy


Mar. 22



noon–1:00 pm M&M

Mar. 29 No Conference

Apr. 5

10:00–11:00 am Gamma Knife–Giller

11:00 am–noon Anatomy


Apr 12




Apr. 1911:00 am–noon Oral Board


Apr. 26



noon–1:00 pm M&M

Vol. 10 - Neuroscience Outlook

Documents

Transcript of Vol. 10 - Neuroscience Outlook