VogelsteinScience15Apr13.pptUpdated: April 15, 2013

Why Is Cancer Therapy Such a Difficult and Often Intractable Effort?

Cancer Genome Landscapes.

Science, Vol. 339, March 29, 2013, pp 1546 – 1548

Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu, Shibin Zhou, Luis Diaz, Kenneth W. Kinzler

Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore

Number of somatic mutations associated with cancers in patients

From 5 or 10 to 130 to 700

mutations per tumor

(Insertions & deletions)

(Single base substitutions)

SignalingPathwaysAffectedIn Cancers

Pathway Anomalies in Progression in Colo-Rectal Cancer

The RAS Pathway as a representative signaling pathway affected by cancer

mutations and approaches to

therapy based on RAS pathway

anomalies

RTK = receptor tyrosine kinase