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    ROGERIO LUZ COELHO NETO

    NÍVEIS REFERENCIAIS SAZONAIS DE VITAMINA D E SUA CORRELAÇÃO

    COM A CARACTERIZAÇÃO DO TIPO DE PELE EM ATLETAS

    PROFISSIONAIS DE FUTEBOL

    Disse!"#$% "&ese'!"(" )%*% e+,isi!% &")i"-&"" " %.!e'#$% (% T/!,-% (e Mes!e e*E(,)"#$% F/si)" (% P%"*" (e PsG"(,"#$% e* E(,)"#$% F/si)"3 (% Se!% (eCi4')i"s Bi%-i)"s (" U'iesi("(e Fe(e"- (%P""'67

    Oie'!"(%8 PROF9 DR9 RAUL OSIEC:I

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    AGRADECIMENTOS

     A"(e#%3 &i*ei"*e'!e3 "% P%?7 D7 R",- Osie)i3 &% !e ")e(i!"(% e* *i* e &% !e")ei!% ess" e*&ei!"(" s%. s," %ie'!"#$%7

     A%s *e,s &"is P%?7 D7 Ri)"(% eie! C%e-sse*%s '" i("7 T"*.>* %s""(e#% &% !ee* i')e'!i"(% '% "*% &e-% es&%!e3 e !ee* *e -e"(% i'*e"s ees"% De&"!"*e'!% (e E(,)"#$% F/si)" (" UFPR3 -," %'(e "%" %-!% (e&%is (e *,i!"s%-!"s &% ess" i("3 &"" ?"e esse *e, Mes!"(%7

     A"(e#% " !%(%s %s "*i%s e )%-e"s (% P%"*" (e Ps G"(,"#$%3 e* es&e)i"- "%

    G,i- i-i*i!"(% &% !"'!"s "es +,e '$% "(i"'!" !e'!" e',*e"7 

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    RESUMO

    INTRODUÇÃO: A Vi!"*i'" D )%-e)"-)i?e%- > )%'si(e"(" ,* &>*+,e " )%')e'!"#$% (e *e-"'i'" " )% (" &e-e !e* i'?-,4')i" '" +,"'!i("(e (e Vi!"*i'"D +,e se &%(, &% ess" eJ&%si#$% s%-" +,"'!% *"is es)," " &e-e3 *"is !e*&% (eeJ&%si#$% s%-" > 'e)ess6i" &"" " *es*" &%(,#$% (e Vi!"*i'" D7 A (e?i)i4')i" (eVi!"*i'" D > &e"-e'!e e* !%("s "s ?"iJ"s e!6i"s e i')-,sie e* "!-e!"s7 H6 "-,'se-"!%s (e e-"#$% (" Vi!"*i'" D )%* " &e?%*"')e es&%!i"7 Dess" ?%*" se !%'"i*&%!"'!e +,e se es!,(e " e&i(e*i%-%i" (" (e?i)i4')i" (e Vi!"*i'" D e* "!-e!"s&%?issi%'"is (e ?,!e.%-7 OBJETIVO: De!e*i'" %s '/eis (e Vi!"*i'" D &e-% 25OHD ₃e )%e-")i%'" esses '/eis )%* es!"#es (% "'% e %s !i&%s (e &e-e (e Fi!&"!i) +,e*e(e " )% e % +,"'!% .%'ei" " &e-e (% i'(i/(,% METODOLOGIA: F%"* "'"-is"(%s1K1 eJ"*es e* ; *%*e'!%s e$% (e 201;3 e$% (e 201@ e i'e'% (e 201@7 F%"*

    *e(i(%s 25OHD e )%*&""(%s esses eJ"*es e'!e "s es!"#es (% "'% e e'!e %s₃!i&%s (e &e-e (e Fi!&"!i)3 +,e ?%"* (ii(i(%s e* &e-e *"is )-"" !i&%s 132 e ; e &e-e*"is es)," !i&%s @3 5 e K7 T"*.>* ?%i &%ss/e- *%'!" ,*" eess$% -%/s!i)" e)"-),-"(% % O((s R"!i% OR (" es&%s!" s,?i)i4')i" (e 25OHD @0 **L ,s"'(%₃%s &e(i!%es &e-e )-"" s7 es),"7 RESULTADOS: N%ss%s ("(%s *%s!"* +,e %s "!-e!"s!i'

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    ABSTRACT

    INTRODUCTION: Vi!"*i' D )

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    SUM(RIO

    ) INTRODUÇÃO:********************************************************************************************************************************************* +

    171 OBXETIVOS777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 K172 OBXETIVOS ESPECÍFICOS77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777K

    , REVISÃO BIBLIOGR(FICA*************************************************************************************************************************-

    271 VITAMINAS7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 W

    272 HISTYRIA DA DESCOBERTA DA VITAMINA D77777777777777777777777777777777777777777777777777777777777777777777777777777777777777

    27; PRODUÇÃO DE COLECALCIFEROL PELA PELE777777777777777777777777777777777777777777777777777777777777777777777777777777777

    27@ COLECALCIFEROL COMO UM PRYHORMNIO77777777777777777777777777777777777777777777777777777777777777777777777777777711

    275 FUNÇ[ES YSSEAS DA VITAMINA D77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777712

    27571 F,'#es sse"s (" Vi!"*i'" D '% i'!es!i'%777777777777777777777777777777777777777777777777777777777777777777777777777777777771227572 F,'#es sse"s (" Vi!"*i'" D '% es+,e-e!%7777777777777777777777777777777777777777777777777777777777777777777777777777777771;2757; F,'#es sse"s (" Vi!"*i'" D '%s i's877777777777777777777777777777777777777777777777777777777777777777777777777777777777777771;2757@ P%ss/eis e-"#es e'!e % *e!".%-is*% sse% e " &e?%*"')e es&%!i"7777777777777777777777777777777777771;

    27K FUNÇ[ES E\TRAYSSEAS DA VITAMINA D777777777777777777777777777777777777777777777777777777777777777777777777777777777777771@

    27K71 P%ss/eis e-"#es e'!e ?,'#es eJ!"sse"s (" Vi!"*i'" D e &e?%*"')e7777777777777777777777777777771@

    27W NÍVEIS REFERENCIAIS DE VITAMINA D 25OHD₃77777777777777777777777777777777777777777777777777777777777777777777777771K

    27W71 V"-%es e?ee')i"is (e 25OHD; &%&,-"#es )%* i')i(4')i" s%-" *6Ji*"777777777777777777777777777777771K27W72 N/eis e?ee')i"is "!,"is (e 25OHD;7777777777777777777777777777777777777777777777777777777777777777777777777777777777777777771

    27 DEFICI]NCIA DE VITAMINA D77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777771

    2771 De?i)i4')i" (e Vi!"*i'" D e* "!-e!"s77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777712772 De?i)i4')i" (e Vi!"*i'" D es&e)i?i)"*e'!e e* "!-e!"s (e ?,!e.%- &%?issi%'"-777777777777777777777777777777722

    27 RELAÇÃO DE NÍVEIS DE VITAMINA D COM PERFORMANCE77777777777777777777777777777777777777777777777777777777772K

    2771 Re-"#$% e'!e % 1325OH2D; e % eJe)/)i%77777777777777777777777777777777777777777777777777777777777777777777777777777777772K2772 S,&-e*e'!"#$% (e Vi!"*i'" D e &e?%*"')e77777777777777777777777777777777777777777777777777777777777777777777777777777772W

    .* METODOLOGIA*****************************************************************************************************************************************,/

    ;71 PARTICIPANTES777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777772

    ;72 SAZONALIDADE77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777 2

    ;72 DOSAGEM DE VITAMINA D777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777772

    ;7; ^UANTIDADE DE MELANINA COR DA PELE7777777777777777777777777777777777777777777777777777777777777777777777777777777777;0

    ;7@ TRATAMENTO ESTATÍSTICO777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777;2

    ;75 DESENHO DO ESTUDO77777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777;@

    0 RESULTADOS********************************************************************************************************************************************* .+

    @71 ESTATÍSTICA DESCRITIVA777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777;5

    @7171 Des)i#$% (%s ("(%s (ii(i(%s &% "'%777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777;K

    @717171 Vi!"*i'" D (e "!-e!"s &%?issi%'"is (e ?,!e.%- e* 201;77777777777777777777777777777777777777777777777777777777;W@717172 Vi!"*i'" D (e "!-e!"s &%?issi%'"is (e ?,!e.%- e* 201@77777777777777777777777777777777777777777777777777777777;

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    @7172 Des)i#$% (%s ("(%s (ii(i(%s &% es!"#$% (% "'%777777777777777777777777777777777777777777777777777777777777777777777777@0@717; Des)i#$% (%s ("(%s (e !i&%s (e &e-e (e Fi!&"!i)7777777777777777777777777777777777777777777777777777777777777777777777@1

    @72 ESTATÍSTICA INFERENCIAL TESTE DE HIPYTESES777777777777777777777777777777777777777777777777777777777777777777777@2

    @7271 C%*&""#es e'!e es!"#es (% "'%777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777777@@@7272 C%*&""#es )%* %s !i&%s (e &e-e (e Fi!&"!i) )%')e'!"#$% (e *e-"'i'"7777777777777777777777777777@5

    @7; ODDS RATIO DA SUFICI]NCIA DE 25OH2 VITAMINA D777777777777777777777777777777777777777777777777777777777777777777@K

    + DISCUSSÃO*********************************************************************************************************************************************** 0/

    1 CONCLUSÃO********************************************************************************************************************************************** +,

    - REFERENCIAS BIBLIOGR(FICAS:**********************************************************************************************************+.

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    ) INTRODUÇÃO:

     A ',!i#$% es&%!i" )%* s,"s &e*iss"s (e *%(i?i)"#$% (ie!>!i)" e

    s,&-e*e'!"#$% "-i*e'!" > ,*" ("s 6e"s (e *"i%es es!,(%s e i*&")!% '% es&%!e (e

    "-!% '/e-7 Ess" ',!i#$% es&%!i" .,s)" " *"',!e'#$% (e ,*" ."se ?isi%-i)" &e?ei!"

    &"" +,e % !ei'"*e'!% &%ss" e" " &%ssi.i-i("(e (es!e "!-e!" !e se, *e- (es&e/e-

    C"."--e%3 200;_ Gi.'e3 200_ L"' "!%?i" *,s),-" 

    D%*i',esF"i" et al.3 201@7

    V6i%s ",!%es !4* *%s!"(% +,e

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    S".ese +,e " (e?i)i4')i" (e Vi!"*i'" D '" &%&,-"#$% e* e"- (e !%("s "s

    ?"iJ"s e!6i" e e* !%("s "s eies (% -%.% > eJ!e*"*e'!e e-e"(" H%-i)3 200@3

    200W_ Vie!* '$%

    eJi!e* es!,(%s +,e )%e-")i%'e* 'esses "!-e!"s &%?issi%'"is %s '/eis (e Vi!"*i'" D

    )%* " +,"'!i("(e (e *e-"'i'" '" &e-e %, " >&%)" (% "'%7

    171 OBXETIVOS

    I(e'!i?i)" "-%es e?ee')i"is (e )%-e)"-)i?e%- Vi!"*i'" D3 e* es&e)i"- se,

    *e!".-i!% 25OHD e* "!-e!"s (e ?,!e.%- &%?issi%'"- (" )i("(e (e C,i!i." PR7₃

    172 OBXETIVOS ESPECÍFICOS

    • D%s" " 25OHD Vi!"*i'" D (e "!-e!"s &%?issi%'"is (e ?,!e.%- (" &i*ei"₃

    (iis$% (% ?,!e.%- ."si-ei% '" )i("(e (e C,i!i." PR7

    • Es!".e-e)e '/eis e?ee')i"is (e 25OHD e* "!-e!"s &%?issi%'"is (e ?,!e.%- ("₃

    &i*ei" (iis$% (% ?,!e.%- '")i%'"- '" )i("(e (e C,i!i." PR7

    •  A'"-is" " Re-"#$% (%s '/eis (e 25OHD (esses '/eis )%* " " )"")!ei"#$%₃

    (%s !i&%s (e &e-e (e Fi!&"!i) )% e )"&")i("(e (e .%'e"*e'!% '" )i("(e (eC,i!i." PR7

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    •  A'"-is" " Re-"#$% (%s '/eis (e 25OHD )%* " s"%'"-i("(e e* +,e esses₃

    eJ"*es ?%e* )%-e!"(%s '" )i("(e (e C,i!i." PR7

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    , REVISÃO BIBLIOGR(FICA

    Ess" eis$% .i.-i%6?i)" *%s!" "% -ei!% %s "s&e)!%s *"is i*&%!"'!es (%

    )%'* !e'!"e*%s *%s!" %s e?ei!%s +,e ess"

    (e?i)i4')i" &%(e !e '% (ese*&e'

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    His!%i)"*e'!e3 % )%-e)"-)i?e%- ?%i " +,"!" s,.s!`')i" " se )-"ssi?i)"(" )%*%

    i!"*i'"7 As i!"*i'"s ?%"* (es)%.e!"s e '%*e"("s e* %(e* )%'%-i)"3 (ess"

    ?%*" % )%*&%s!% +,e ),"" "+,i!is*% *"is !"(e i(e'!i?i)"(% )%*% )%-e)"-)i?e%-

    ?i)%, )%'&%)" se !%'%, )%*,* e* "-,*"s &"!es (" I'-"!e"3 se'(% )

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    (>)"("s (e 120 e 1;0 " es!,!," e ?,'#es (% )%-es!e%-7 Se,s !"."-*i)" +,e es,-!" '% )%-e)"-)i?e%-7 U*" &%!e/'" )"e"(%" )

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    27@ COLECALCIFEROL COMO UM PRYHORMNIO

    O )%-e)"-)i?e%- > % *"is i*&%!"'!e se)%es!e%i(e e* .e)+3 123 e=" " Fi," 27

    C%*% % )%-e)"-)i?e%- &%(e se &%(,i(% &e-" &e-e3 e &%+,e s," ?%'!e (ie!>!i)" >

    (es&e/e- % *"is )%e!% > )%'si(e6-% ,* &%* (iss%se, e)e&!% % VDR > (" *es*" s,&e?"*/-" (e e)e&!%es +,e %s es!e%i(es B%(i"-"

    et al.3 200@_ C"-.e et al.3 201;7

    Fi," 28 Es!,!,"s ^,/*i)"s (% )%-es!e%- ")i*" e )%-e)"-)i?e%- "."iJ%7 N% )%-es!e%- es!$% "'%!"(%s %s @"'>is )-6ssi)%s (e A " D +,e (e?i'e* " *%->),-" )%*% ,* es!e%i(e7 N%!"se +,e % )%-e)"-)i?e%- !e* "*es*" es!,!,"3 eJ)e!% &% ,*" +,e." (" -i"#$% )".'i)" e'!e %s )".%'%s C e C10 +,e ?%*"i"* %"'e- B7 P% esse *%!i% % )%-e)"-)i?e%- > )

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     A&s se &%(,i(% &e-" &e-e3 % )%-e)"-)i?e%- +,e > .i%-%i)"*e'!e i'e!e (ee

    se !"'s?%*"(% '% ?/"(% e* 25* "s

    ?,'#es eJ!"sse"s :"'is3 12_ Bi-e3 2007

    275 FUNÇ[ES YSSEAS DA VITAMINA D

     As ?,'#es sse"s (% )%-e)"-)i?e%- s$% (ie!"*e'!e e-")i%'"("s " +,"'!i("(e

    (e C6-)i% )i),-"'!e '% s"',e7 ^,"'(% % C6-)i% (i*i',i '% s"',e '$% %)%e*i'e"-i"#$% sse"3 e iss% %)"si%'" "+,i!is*% e* )i"'#"s e %s!e%*"-6)i" e* "(,-!%s

    DeL,)"3 200@7

    P"" *"'!e " )%*&-e!"*e'!e (e&e'(e'!e (" e-"#$% (" Vi!"*i'" D

    "!i"(" 1325OH D +,e &%>* (%s i's e !"*.>* (% e)e&!% (e i!"*i'" D VDR₂ ₃

    )%* %s !"'s&%!"(%es "!i%s (e C6-)i% C"2 ATP"se e " .%*." N"2C"2 '" &"e(e (%

    i'!es!i'% (e-"(%7 A->* (iss%3 " Vi!"*i'" D !"*.>* > " &i')i&"- es&%'s6e- &e-"

    ".s%#$% (e ?%s?"!%s '% i'!es!i'% &e-" "!i"#$% (% )%!"'s&%!e N" 2Pi  DeL,)"3 200@_

    D,ss%3 B%' e S-"!%&%-s3 20057

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    27572 F,'#es sse"s (" Vi!"*i'" D '% es+,e-e!%

    N" ?"-!" (e C6-)i% "-i*e'!"3 %s '/eis s"',/'e%s &%(e* ."iJ" *,i!% e iss%

    &%(e )",s" !e!"'i" * &e-% * s,&i*e " &%-i?e"#$% ("s -`'(,-"s &""!ie%i(es

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    si'i?i)"!i% +,"'(% ""-i"(% +,e *"is (e W (e C6-)i% &"ss"* &e-%s i's (i"i"*e'!e

    DeL,)"3 200@7

    2757@ P%ss/eis e-"#es e'!e % *e!".%-is*% sse% e " &e?%*"')e es&%!i"

     As ?"!,"s s$% i'(ie!"*e'!e "ss%)i"("s )%* " (e'si("(e (% %ss%7 A (e'si("(e

    sse" > *e!".%-i)"*e'!e "ss%)i"(" )%* " +,"'!i("(e (e Vi!"*i'" D )i),-"'!e :"'is3

    12_ :"'is e Pi!!3 12_ :"'is et al.3 1@_ DeL,)"3 200@_ D,ss%3 B%' e S-"!%&%-s3

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     As ?"!,"s &% es!esse s$% &e"-e'!es e* "!-e!"s (e endurance e !"*.>* '"s

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    ?%#"s "*"("s R%*e3 H"'(%-- e As

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    "&"e)e* " Vi!"*i'" D es!6 "ss%)i"(" " &e?%*"')e es&%!i" )"(i%"s),-"3 " ?"-!" (e

    "("&!"#$% )"(/")" "% eJe)/)i% e* "!-e!"s see"*e'!e (e?i)ie'!e &%(e -i*i!" ess"

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    P",- et al.3 2012 !"*.>* &"e)e* e-")i%'"(%s )%* ."iJ" Vi!"*i'" D3 e ?,'#es

    &,-*%'"es &"e)e* es!" (i*i',/("s e* "!%s "-i*e'!"(%s se* )%-e)"-)i?e%- Z%s et 

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    es!,("(" &% C

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    27W NÍVEIS REFERENCIAIS DE VITAMINA D 25OHD₃

     A &%(,#$% (e Vi!"*i'" D &e-" &e-e &%(e se ,* (%s ?"!%es *"is i*&%!"'!es '"

    (i?ee'#" e%-,!i" (e !%'"-i("(e (e &e-e )%'?%*e se ",*e'!" " -"!i!,(e (is!`')i" ("

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    27 RELAÇÃO DE NÍVEIS DE VITAMINA D COM PERFORMANCE

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    .* METODOLOGIA

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    0 RESULTADOS

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    +,e *es*% +,e ess"s eJ!"&%-"#es '$% se="* eJ"!"*e'!e )%')%("'!es )%* %s ("(%s

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    1 CONCLUSÃO

    Esse es!,(% )%'se,i, *%s!" " i*&%!`')i" +,e " Vi!"*i'" D &%(e i " !e '%

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    - REFERENCIAS BIBLIOGR(FICAS:

     AGHAXAFARI3 F7 et al. Ass%)i"!i%' .e!ee' *"!e'"- se,* 25

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    BODIALA3 D7 et al. P%-*%&

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    e(7 H%.%e'3 NX8 X7 i-e t S%'s3 2007DELUCA3 H7 F7 Oeie %? e'e"- &r2a6 J&4r6al & Cl262al N45r252&63 7 03 '7 K3 &7 1KS1KKS3 1 (e7 200@7DHESI3 X7 :7 et al. Ne,%*,s),-" "'( Ps)

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    XAC:MAN3 R7 7_ :ANDARIAN3 S7 C7 T

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    LOOMIS3 7 F7 Si'Pi*e'! Re,-"!i%' %? Vi!"*i'D Bi%s'!r2a6 J&4r6al & Cl262al N45r252&63 7 WK3 '7 13&7 1W123 1 =,-7 20027NOBEL PRIZE ORLD SCIENTIFIC ED7 N&l l54rs 26l4'263 @rs65a52&6

    s@hs a6' la4ra5s 2&3ra@h2s: Ch>2s5r$ )/,,Q)/0)* Si'"&%e_ Rie E(e3NX8 %-( S)ie'!i?i)3 17NORMAN3 A7 7 F%* i!"*i' D !%

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    ss!e* esse'!i"- ?% %%( @452637 Vie''"3 A,s!i"8 R F%,'("!i%' ?% S!"!is!i)"- C%*&,!i'3 201@7REID3 I7 R7_ BOLLAND3 M7 X7 R%-e %? i!"*i' D (e?i)ie') i' )"(i%"s),-" (ise"se7!ar53 7 3 '7 3 &7 K0K1@3 15 ".7 20127RING3 S7 M7_ DANNEC:ER3 E7 A7_ PETERSON3 C7 A7 Vi!"*i' D S!"!,s Is N%! Ass%)i"!e(

    i!< O,!)%*es %? EJ&ei*e'!"--I'(,)e( M,s)-e e"'ess "'( P"i' i' %,'3 He"-!3 7 20103 20107ROME3 :7_ HANDOLL3 H7 H7_ ASHFORD3 R7 L7 I'!ee'!i%'s ?% &ee'!i' "'( !e"!i's!ess ?")!,es "'( s!ess e")!i%'s %? .%'e %? !r2a6 D2552 Ass&2a52&63 7 1053 '7 K3 &7 W1W@3 =,'7 20057TANGPRICHA3 V7 et al. Vi!"*i' D i's,??i)ie') "*%' ?ee-ii' r2a6 J&4r6al & M'2263 7 1123 '7 3 &7 K5KK23 1 =,'7 20027TENFORDE3 A7 S7 et al. E"-,"!i' !

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