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Simulation of Mixing Processes

VisiMix Ltd, PO Box 45170, Jerusalem, 91450, Israel Tel: 972 - 2 - 5870123 Fax: 972 - 2 - 5870206 E-mail: info@visimix.com

VViissiiMMiix x

Simulation of Mixing Processes

Presentation Contents:

- The Customers

- The Technology

- ROI

- VisiMix Products

- Saving Examples

About UsAbout Us

VisiMixVisiMix is a unique software enabling is a unique software enabling chemical engineers, process engineers and chemical engineers, process engineers and

R&D personnel to R&D personnel to visualize mixing processesvisualize mixing processes via a simple, user friendly interface. via a simple, user friendly interface.

Our products allow significant savings in time Our products allow significant savings in time and costs by drastically reducing the need for and costs by drastically reducing the need for trial-and-error. They have been successfully trial-and-error. They have been successfully

adopted by hundreds of companies.adopted by hundreds of companies.

VisiMixVisiMix is a unique software enabling is a unique software enabling chemical engineers, process engineers and chemical engineers, process engineers and

R&D personnel to R&D personnel to visualize mixing processesvisualize mixing processes via a simple, user friendly interface. via a simple, user friendly interface.

Our products allow significant savings in time Our products allow significant savings in time and costs by drastically reducing the need for and costs by drastically reducing the need for trial-and-error. They have been successfully trial-and-error. They have been successfully

adopted by hundreds of companies.adopted by hundreds of companies.

Customers and MarketsCustomers and Markets

Our Customers

What Our Customers Say About Us

From the Dow Chemicals Intranet Website

“VisiMix: This is a highly accessible PC software for mixing calculations available from VisiMix Ltd., an Israeli company. It is a rating calculation tool for both non-reactive and reactive mixing involving blending, solid suspension, gas dispersion, liquid-liquid dispersion, or heat transfer processes in stirred vessels. It calculates the important process parameters for single- and two-phase systems – power consumption, circulation rates, local concentrations of solutes and suspended particles, drop size, concentrations of reactants, etc … ”

Dr. Victor Atiemo-Obeng

Dow Chemicals Co.

What Our Customers Say About Us

“I am very pleased in applying your software.”

L'Oreal, France

“We have been using VisiMix. We have found it an accurate tool ... Based on our success with the product, our Japanese colleagues at Fuji Xerox have bought a copy for their work.”

Emily Moore,Xerox Research Center of Canada

Customers and MarketsCustomers and Markets

Customer List

1. L'Oreal, France2. BASF AG, Germany 3. Dow Chemical Company, USA 4. Searle (MONSANTO), USA5. Lightnin, USA6. LG Chemicals, S. Korea 7. Xerox , Canada & USA 8. The Gillette Co., USA & UK 9. De Dietrich, France & USA 10. ENIChem, Italy 11. Eli Lilly & Company, USA 12. NIPPON, Japan 13. Novartis, USA14. Millennium, USA15. ICI, UK 16. Hercules, USA 17. Pfizer, USA&UK&Gr.18. Mitsubishi Chemicals 19. Abbott Laboratories, USA20. GlaxoWellcome,UK&Singapore

1. L'Oreal, France2. Techmix S.r.o, Czesh Republic3. BASF AG, Germany 4. BASF, Denmark 5. BP Chemicals - Wingles, France6. Sanofi Recherche, France7. Technimont, Italy 8. Nycomed Imaging, Norway9. Hoesch & Sohne, Germany10. DSM, The Netherlands11. Searle (MONSANTO), USA12. Lightnin, USA13. Chevron, USA14. Teva, Israel 15. Plantex, Israel16. Bromine Compounds, Israel17. ENSIC, France18. LG Chemicals, Taejon-city, S. Korea 19. LG Tech, Yeochon-city, S. Korea 20. Lonza, Switzerland21. Thai Plastic and Chemical Public Company, Thailand22. Xerox Research Centre of Canada, Canada 23. Xerox, USA 24. The Gillette Co., USA 25. Gillette, UK 26. Lecaros, Chile 27. SK Chemicals, S. Korea 28. Dow Chemical Company, USA 29. Monsanto, USA 30. Buchi AG, Switzerland31. Agisys, Hungary 32. Samsung, S. Korea 33. Mervers, Holland 34. American Cyanamid Company, USA35. Belinka Belles, d.o.o., Slovenia36. LG Chem. , ABS Division (S. Korea)37. BFGoodrich Advanced Technology Group, US38. PT MECO INOXPRIMA, Indonesia39. Ion Exchange, India40. IL JIN Eng. & Const. Ltd., Korea41. CSIR Ltd., South Africa42. PTI, Brazil

43. De Dietrich, France 44. De Dietrich, USA 45. Rhodia (Rhone Poulenc Group), Brazil46. Inymassa, Spain 47. ENIChem, Italy 48. Satake, Japan49. Chesebrough-Pond’s, USA 50. Unilever, Italy51. Schering-Plough, USA52. Ontec, Israel53. Cytec, USA54. Degussa, Germany55. IHN Groningen BV, the Netherlands 56. PEAS BV, the Netherlands57. Eli Lilly & Company, USA 58. BSL (Dow group), Germany 59. VMD PTE Ltd., Singapore 60. Tecnicas Reunidas, Spain 61. NIPPON, Japan 62. Chr. Hansen, Denmark63. Danisco, Denmark 64. Novartis, USA 65. SNECMA, France 66. Millennium, USA 67. Ucosan B.V., Holland 68. Norde Veenendaal B.V., Holland 69. Akzo Nobel, Germany 70. Astra Charnwood, UK 71. ICI, UK 72. Stork, Netherlands73. Hercules, USA 74. Luigi Menestrina, Italy 75. Siersma Leidshendam, the Netherlands76. Sara Lee, the Netherlands 77. Pfizer, USA 78. Pfizer, UK 79. Pfizer, Germany 80. Beiersdorf AG, Germany81. Sintef Applied Chemistry, Norway 82. Chemitec OY, Finland 83. Makhteshim, Israel 84. Chemagis, Israel

85. Nitto Denco, Japan 86. 3M, USA 87. Broom Chemie, the Netherlands88. Atlas-Stord, Denmark89. Canon, Japan 90. Mitsubishi Chemicals 91. Imation, USA92. NIKKI, Japan 93. Fuji Xerox, Japan94. Oxy Vynils95. Scanlube, Sweden 96. GlaxoWellcome, Singapore97. GlaxoSmithKline, UK98. SmithKline Beecham, USA 99. M&F Process Simulation, The Netherlands100. Abbott Laboratories, USA 101. Air Products, USA102. Gruppo Lepetit, Italy 103. Johnson Polymer, Holland 104. Dow Corning, USA 105. Pharmacia Biotech, Sweden106. Panandiker Research & Development (P) Ltd., India107. Fujifilm, Japan108. Katholieke Hogeschool Brugge-Oostende, Belgium109. The Casali Institute, Israel110. Noordelijke Hogeschool Leeuwarden, the Netherlands111. Stettin University112. Taiwan University113. Ecole d'Electrochemie, France114. Ecole Polytechnique, Canada115. University of Western Ontario, Canada 116. University of Barcelona, Spain 117. Taejon National University, S. Korea118. Otto von Guericke Universitat, Germany119. Tsinghua University, China120. VUOS, Czesh Republic121. Universita di Roma, Italy122. Hanyang University, S. Korea123. Royal Institute of Technology, Sweden

Total : 123 customers

De Dietrich - ExampleDe Dietrich - Example

http://www.ddpsinc.com/MixingSimulations.htm

De Dietrich - ExampleDe Dietrich - Example

http://www.ddpsinc.com/Visimix.htm

Simple and Effective - InterfaceSimple and Effective - Interface

Technology - Simulation of Mixing Processes

Simple and Effective - BackgroundSimple and Effective - Background

Technology - Simulation of Mixing Processes

The First and the only tool in the IndustryThe First and the only tool in the Industry

Reliable and accurate resultsReliable and accurate results

Based on More Than 300 Man Years of R&D andBased on More Than 300 Man Years of R&D and Industry Experience Industry Experience

Replacing Pilot Experiments Replacing Pilot Experiments

Accelerated Time-to-Market processAccelerated Time-to-Market process

User Friendly and easily accessibleUser Friendly and easily accessible

Simple and EffectiveSimple and Effective

Return On Investment (ROI)

Per Year basisPer Year basis

$15,000$15,000Savings Per project - $20,000 Per year - $150,000 (5-10 projects per year)

Savings Per project - $20,000 Per year - $150,000 (5-10 projects per year)

QualityQuality

TimeTime

Time To MarketTime To Market

Product Cost Benefits (The ICI Example)

$15,000$15,000$15,000$15,000$15,000$15,000$15,000$15,000

VisiMix Products

VisiMix software:

• Based on advanced scientific knowledge and practical expertise

• User-friendly and easy to operate

• Requires easily accessible initial data

The latest VisiMix products are: • VisiMix 2K8 Turbulent • VisiMix 2K8 Laminar • VisiMix 2K8 Different Impellers• VisiXcel

Introduction

VisiMix Products

• VisiMix 2K8 Turbulent – for low-viscosity liquids and multiphase systems.

The program provides process parameters necessary for analysis, scaling-up and optimization of mixing tanks and reactors with all types of impellers

VisiMix Software Products

Calculations of: Blending Suspension Dissolution Emulsification Gas dispersion Heat transfer Chemical reactions Mechanical stability of shafts

VisiMix Products

• VisiMix 2K8 Laminar - for highly viscous media

VisiMix Software Products

•    pastes•    creams•    shampoos•    liquid soaps•    gels•    ointments•    paints:•    coatings•    slurries•    polymer solutions

Newtonian and non-Newtonian Macro-scale blending Micromixing in high-shear areas Heat transfer

VisiMix Products

• VisiMix 2K8 Different Impellers – for combined mixing devices

VisiMix Software Products

The program handles mixing devices consisting of any 2 – 5 impellers. Different distances between impellers

Used in combination with VisiMix Turbulent.

Provides parameters of hydrodynamics, turbulence and heat transfer.

 • VisiMix VisiXcel – automatic conversion of VisiMix output

parameters into Excel spreadsheets.

Integrating VisiMix report parameters in standard Excel worksheets

Analyzing VisiMix results in Excel

VisiMix Orientation

The VisiMix Demonstration Tools:

VisiMix Demonstration Tools

VisiMix Turbulent – Examples & User Guide

VisiMix Laminar - Examples & User Guide

VisiMix Different Impellers – Examples & User Guide

VisiMix Turbulent SV – Trial & Education

VisiMix Review of Mathematical Models

Selected Verification Examples The Comparison between Published Experimental Data and

VisiMix Calculations

Saving ExamplesSaving Examples

Finance Saving Examples (ROI)

1. Cooling A Paste

2. Paints

3. Suspension in a Batch Reactor

4. Scale up Methodology

Finance Saving Examples (ROI)Finance Saving Examples (ROI)

Example Case Classic Solution Visimix Solution

Saving

Cooling of a Paste

Batch Production Time

Replacement of the whole mechanical

system

Input the existing mixing systems parameters to

VisiMix software, implement small

changes

$125,000 per year

Paste and Coating

Mixing several components to

obtain high quality paint during scale-

up process

Increase the impeller speed and improve the

heat removal in the tank. No successful

results obtained

Change agitator dimension for

uniform mixing without

overheating

$40,000 per year

Suspensions in a batch

reactor

Plugging of the bottom valve of the

reactor

Replacement of the agitator

Lower the impeller position

$12,000 saved on the cost of a new impeller and for all associated

operational costs

Scale up Methodology

Implementation during the Scale

studies

Calculation after finishing the

development stage

Calculation during the

development stage

Decrease in the quantity of out of

spec material in the launching and

production steps.

Cooling a Paste

Cooling a Paste

Cooling a Paste

Cooling a Paste

Cooling a Paste

PAINTS

PAINTS

PAINTS

PAINTS

PAINTS

PAINTS

Suspension in a batch reactor

Suspension in a batch reactor

Suspension in a batch reactor

Suspension in a batch reactor

Suspension in a batch reactor

Scale Up MethodologyScale Up Methodology(J.M. Berty. CEP, 1979)(J.M. Berty. CEP, 1979)

Scale Up MethodologyScale Up Methodology(J.M. Berty. CEP, 1979)(J.M. Berty. CEP, 1979)

Scale up optimization using simulation experiments.Scale up optimization using simulation experiments.

Scale Up MethodologyScale Up Methodology(J.M. Berty. CEP, 1979)(J.M. Berty. CEP, 1979)

Scale Up MethodologyScale Up Methodology(J.M. Berty. CEP, 1979)(J.M. Berty. CEP, 1979)

Scale up optimization using simulation experiments.Scale up optimization using simulation experiments.

Scale Up optimization using simulation experiments.Scale Up optimization using simulation experiments.

In the three years since the commencement of this process, their engineers achieved a high level of proficiency in the use of the simulation models in order to analyze the results as a function of the process operational parameters. After three years of working with this integrated plan – they have summarized their knowledge and experiences up to this point, as follows: 1. VisiMix products, when integrated in the validation process (up until they

achieved a stable process and confirmed the production) – helped to reduce the number of lost production batches (each batch valued in millions of dollars) - from 100 to just under 10 batches – (review slide 25)

2. VisiMix program used in conjunction with another simulation tool - as

reported in this presentation - contributed to the improvement of the teamwork style and professionalism. Net results were observed throughout the implementation of the new solution in better project development: EOR (end of reaction) time reductions, projects development time and cost reduction, and in addition - increasing the expertise and qualification level of the professional staff.

The presentation can be review on the Visimix Website in the References - Users Publications page. (Scale up optimization using simulation experiments-Chemagis

presentation)

Financial aspectsFinancial aspects# produced lots until achieving to a stable

process

Scale Up optimization using simulation experiments.Scale Up optimization using simulation experiments.

SummarySummary

• Save per project

• Save during development

Thank You

Positive reaction from customers from all over the world confirms:

- VisiMix is of tremendous help wherever mixing is involved.

Thank you

From the VisiMix Team

Thank you for your attentionThank you for your attention