By: Simon Authier, D.V.M., M.Sc., M.B.A. Head of Veterinary Services

Veterinary Structure at LAB Research Inc.

2

LAB Research CANADA

Founded in 1998

220 employees

87,000 sq.ft.

LAB Research DENMARK Founded in 1978

176 employees

93,000 sq.ft.

in Q3 2007

LAB Research HUNGARY Founded in 1974

128 employees

142,000 sq.ft.

in Q3 2007

LAB Research Global

3

LAB Research Canada

4

Organizational Chart

2006 / 2007

President and CEO

Manager Marketing Manager Human Resources

Vice-President Business Development

Chief Operating Officer

Vice-President Finances

Executive Assistant

5

Organizational Chart

2006 / 2007

Chief Operating Officer

VP Research and Immunology VP Toxicology

Head of Histopathology

Head of Pharmacy

Director of Bioanalytical Services

Head of Building Maintenance

Head of Veterinary Services

Head of Clinical Pathology

Senior Director of Quality Assurance

6

Organizational Chart

2006 / 2007

Head of Veterinary Services

Clinical Veterinarian Clinical Veterinarian Technical Team Leader Research Surgeon Research Veterinarian

and Surgeon

Veterinary Technician Veterinary Technician Veterinary Technician Veterinary Technician Veterinary Technician Veterinary Technician

7

LAB Research Canada Species Distribution - By Sep 07

Rat

23%

Dog

24%

Cyno

33%

Minipig

2%Rabbit

9%

Mice

9%

Pig

0%

8

Veterinary Services

Responsibilities: • Animal Health • Review and Improvement of

Animal Care Program • Enrichment program • Model development • Safety Pharmacology • Surgeries • Training

9

Veterinary Services Animal health: Our primary mission

Veterinary examinations Schedule on central server Internal client services Diagnostic tools Psychological evaluations

10

Veterinary Services Overview of the Animal Care Program

Review and Improvement of Animal Care

Program Semi-Annual Program Review Training on animal ethics Accreditation Visits (CCAC and

AAALAC) Review of SOPs Post-Approval Monitoring

11

Veterinary Services Animal Welfare

Enrichment Program

Enrichment Committee → Subcommittee of IACUC Terms of reference and membership detailed in SOP Members from all departments Chairperson: Clinical Veterinarian Dedicated budget Weekly Enrichment Schedule with formal checks Committee to develop new opportunities Pilot projects → Results reported to IACUC

12

Models Developed in Collaboration with the Veterinary Team

Animal Models Rat Mice Rabbit Dog NHP M-Pig Pig

Arterial restenosis x

Surgical wound healing x x x x

Skin resurfacing x x

Bile duct catheter x

Dialysis x x

Hepatic hemostasis x

Portal vein catheter x x

Intrathecal catheters x x

Anesthetized hypoxemic model x

Gastric emptying time x x x

Intracardiac electrocardiographic leads x

Duodenal or Jejunal or Ileal catheters x x x

Hepatic Cirrhosis x

Electroencephalography using telemetry x

Electroretinography x

Glomerular filtration Rate CT-Scan x x

Whole body fluorescence imaging x x

13

Safety Pharmacology Contributing to Science

Veterinary expertise to help develop models Physiology (Neurology, Cardiology and Respiratory Physiology) Pharmacology Surgery

CNS In rodents and non-rodents

Respiratory

In rats, dogs, primates Cardiovascular

Telemetry in dog and primate Hemodynamic – in anesthetized and conscious dogs and primates

14

Veterinary Services Quality of Cares

Surgeries Performed by all veterinary services staff (diversity of

tasks) Standard and development Prophylactic treatments Veterinarian → Project Manager

15

Veterinary Services Hand in hand with the organization

Participation to organizational meetings 3 members of the IACUC 1 member of Process optimization meetings 1 member of Crisis management planning team 1 member of Risk management team 1 member at Corporate R & D meetings Important contributor to animal supplier selection

16

Thank you!