Vertebrate Embryonic Patterning 5 Neural Crest. Neural Crest Cells.

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Vertebrate Embryonic Patterning 5 Neural Crest

Transcript of Vertebrate Embryonic Patterning 5 Neural Crest. Neural Crest Cells.

Page 1: Vertebrate Embryonic Patterning 5 Neural Crest. Neural Crest Cells.

Vertebrate Embryonic Patterning 5

Neural Crest

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Neural Crest Cells

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Neural Crest DerivativesTwo major divisionsCranialTrunk

PNS EndocrineMelanocytesFacial CartilageConnective Tissue

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Trunk Neural Crest

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Neural Crest Cells Stain Positive for ECM Protein HNK-1

RhoB

HNK-1

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Migratory Pathways of Neural Crestephrins expressed in posterior

compartment of somite

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Ephrin – Eph RTK Pathway Regulates NC Migration Through/Over Somites

Eph RTKs and ephrins appear to regulate boundary formation and cell-cell interactions in many regions of the embryo

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Ephrins Repulse Axon Growth

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Signals from the Floorplate Induce Axon Migration

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Netrin Induces Commissural Axon Growth

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Semaphorins Repulse Axons

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Axonal Guidance in Invertebrates

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Eph RTK & Ephrins Regulate Retinotectal

Patterning