VASODILATORS

VASODILATORS MNEMONICS: Classifications: COP SI RAAS CALCIUM CHANNEL BLOCKERS ORGANIC NITRATES DRUGS FOR PULPMONARY ARTERIAL HYPOTENSION SYMPATHOLYTIC DRUGS INDIVIDUAL VASODILATOR DRUGS ACTING ON THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM CLASSIFICATION CATEGORY MECHANISM OF ACTION DRUGS (Generic-Trade name) Drug MNEMONI CS 1.) INDIVIDUAL VASODILATOR Some of the drugs act primarily on arterioles, some act on veins, and some act in both the type of vessel. Some agents produce selective dilation of arterioles. Minoxidil Sodium Nitroprusside Diazoxide Hydralazine Mi So Di Hy 2.) DRUGS ACTING ON THE RENIN- ANGIOTENSIN- ALDOSTERONE SYSTEM Plays an important role in regulation of BP, blood volume, and fluid and electrolyte balance, a key component of the system – angiotensin II is a powerful vasoconstrictor that acts on arterioles and veins. Hence, by blocking either the formation or actions of angiotensin II, we can promote dilation of arterioles and veins. Captopril Losartan Aliskiren Valsartan Enalapril C L A V E 3.) ORGANIC NITRATES Produce selective dilation of veins; dilation of arterioles is minimal. The primary indication for these drugs is angina Nitroglycerin Isosorbide dinitrate Niso

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Transcript of VASODILATORS

VASODILATORSMNEMONICS:

Classifications: COP SI RAAS

CALCIUM CHANNEL BLOCKERSORGANIC NITRATESDRUGS FOR PULPMONARY ARTERIAL HYPOTENSION

SYMPATHOLYTIC DRUGSINDIVIDUAL VASODILATOR

DRUGS ACTING ON THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

CLASSIFICATIONCATEGORY

MECHANISM OF ACTION DRUGS (Generic-Trade name) Drug MNEMO

NICS

1.) INDIVIDUAL VASODILATOR

Some of the drugs act primarily on arterioles, some act on veins, and some act in both the type of vessel. Some agents produce selective dilation of arterioles.

MinoxidilSodium NitroprussideDiazoxideHydralazine

MiSoDiHy

2.) DRUGS ACTING ON THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Plays an important role in regulation of BP, blood volume, and fluid and electrolyte balance, a key component of the system – angiotensin II is a powerful vasoconstrictor that acts on arterioles and veins. Hence, by blocking either the formation or actions of angiotensin II, we can promote dilation of arterioles and veins.

CaptoprilLosartanAliskirenValsartanEnalapril

CLAVE

3.) ORGANIC NITRATES

Produce selective dilation of veins; dilation of arterioles is minimal. The primary indication for these drugs is angina pectoris; In addition, nitroglycerin is given to treat heart failure and myocardial infarction, and to provide controlled hypotension during surgery.

NitroglycerinIsosorbide dinitrate

Niso

4.) CALCIUM CHANNEL BLOCKERS

Produce vasodilation by preventing calcium entry into VSM. At therapeutic doses, these drugs produce selective dilation of arterioles. Primary indications are hypertension and angina pectoris.

DiltiazemVerapamilNifedipineIsrapidine

DiVeNi

5.) SYMPATHOLYTIC DRUGS

Promotes vasodilation by preventing the sympathetic nervous system from causing

PrazosinTerazosin

PleaseTell

vasoconstriction. Some of these drugs act by direct blockade of vascular adrenergic receptors. Others on sympathetic ganglia, adrenergic neurons, or the CNS.

MecamylamineGuanadrelClonidineReserpine

PhentolaminePhenoxybenzamineMethyldopa

MyGrandChildRyan

6.) DRUGS FOR PULPMONARY ARTERIAL HYPOTENSION

Used to dilate pulmonary blood vessels in patients with pulmonary arterial hypertension. Ambrisentan bosentan block vascular receptors for endothelin-1, a powerful vasoconstrictor. Epoprostenol and treprostinil stimulate production of cyclic AMP in vascular smooth muscle.

BosentanEpoprostenolBosentanTrepostinil

BEBoT