Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes
description
Transcript of Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes
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Vasculogenesis and angiogenesis
Integrins in vasculature and KO phenotypes
Growth Factor Receptors signaling and vasculature phenotypesVEGFRTip cells VEGF, Notch
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Vasculogesis and angiogenesis in vertebrates
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Models Intussuseptive angiogenesis
(tissues as muscle, often blood flow dependent etc.)
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Angiogenesis is a dynamic and context determined process
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Examples of vascular defects
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Integrins in the vasculature
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L1CAMA7Lm68% embryonic lethal hemorrgaged E10-14.5 SM cells
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Integrin inhibitors and RTK agonistic interactions (Kaan)
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Angiopoitins, Tie1 and Tie2 receptor
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PDGF RTK signaling
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VEGF RTK signaling
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VEGFR3 at tips cells
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Signaling in sprouting tip cells
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Delta-Notch signaling
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Sema3 inhibits integrin function. Normal angiogenesissemaphorins
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Mouse models affecting TGFbeta signaling
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Haemodynamics affect vascular remodellingexample
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Pixt2 KO phenotypes in 6th BAAOcclusion of right BAAs results in Persistence of left 6 BAA