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VASCULITISVasculitis C/F Bx/Micro Tx

LARGE-vessel: Aorta & its a!or "ra#c$es

Te%oralGia#t Cell'

Arteritis

F > M, >50yo

- Usually at branches of carotid artery- headache (temporal)- visual disturbances (ophthalmic)- ja claudication- polymyal!ia rheumatic ("u-li#e s$ % joint & muscle pain)

' (>*00)

+ranulomatous

n"amed vesselall % !iant cells& intimal brosis

(.i!h-dose)/orticosteroids

()IG) ris* o+"li#,#ess /otx..

Ta*aasuArteritis

01ulseless234'

dults 150yo(youn!, sian female)

- ortic arch at branch points- visual & neuro s$- ea# or absent pulse in upper e$tremity

'

+ranulomatous /orticosteroids

ME2IUM-vessel: i#volve uscular arteries t$at su%%l or5a#s

1olarterits#o,osa 1A6'

23 4U2+

6oun! adult

- .72 (renal artery)- abdom pain % melena (mesenteric artery)- neuro disturbances- s#in lesions

((((A/7: )BsA5((((

2eutrophils 8Fibrinoid 2ecrosis(F2)

0stri#5 o+%earls4 onima!in!

/orticosteroids/yclophosphame

F74 %o t$

8aasa*i 23

(M/ sian) #ids 19yo

:ects Coro#ar Arter..((- 7hrombosis Mneurysmupture

0CRAS) & "ur#4(2onspecic $)ConjunctivitsRash (des;uamatin!)Adenopathy (cervical)Straberry ton!ue)and-foot chan!es (edema, erythema)& Fever

IVIG 9 As%iri# F 90-B0yo

+ranulomas inC*) 23'C Dsaddle noseE (DC-shapedE depression of nose)) 2U'C Chronic sinusitisG) 4U2+C Cavitary !ranulomas9) ?@2'6C F2 +2

2eutrophils 8 F28 Gra#uloas

C-A6CA 1R'

4U2+, ?@2'6, ?2 % pauci-immune +2 & alpable urpura

- $%nf$

6?5ra#uloas..

2eutrophils 8 F2

1-A6CA M1?'9

/orticosteroids/yclophospham

e

elapses Icommon

C$ur5-Straussaller5ic

5ra#uloatosis & a#5iitis's#,roe

1A6 varia#t=@'

6oun! males

4U2+ & .'7

TRIA2:>' Gra#uloas@' Ast$a

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- 1al%a"le 1ur%le 1ur%ura o# "uttoc*s/le5s- + pain & bleedin!- .ematuria (! nephropathy%Aer!er @J)- rthral!ias

severe