Vascular Function Curve
1
Qheart = 0L/min t0: Q = 0 Qresistance vessles = 0L/min Parteries = 7mmHg Pveins = 7mmHg t0: Q = 0 Mean Circulatory Pressure or Static Pressure = 7mmHg Compliance and Volume only factors Flow = 0 1)Stepwise increase in CO See how CVP changes SVR = 20mmHg/L/min Cardiace Output increase = decrease in CVP t1: Q = 1 Initial increase in CO -Blood redistributes from Venous circulaiton -Blood accumulates in Arterial circulation this is due to an IMBALANCE between output from the Heart and Resistance vessles T1: Q = 1 Qrv < (Qco =1) Pressure here increases Pressure Here decreases ΔP here provides Driving Force required to Match flow through Resistance vessels with CO ΔP ΔP depends on SVR Qvein = Qresistance vessels Veins Resistance Vs = Volume = 1 19 19 1 Pressure Compliance x Compliance x 19 19 Pressure 19 19 constant, same for veins and resistance vessles dV = C x dP Compliance Arteries = 1 Compliance Veins = 19 dPveins = 1 dPresist vs = 19 Cardiac Output L/min CVP mmHg 1 2 3 4 5 6 7 -1 0 1 2 3 4 5 6 7 8 9 8 9 Mean Circulatory Pressure = 7mmHg Cardiac output 0 1 2 3 4 5 6 7 140 130 120 110 100 90 80 70 60 50 40 30 20 10 0 Arterial Pressure mmHg 7 6 5 4 3 2 1 0 -1 Venous Pressure mmHg Resistance: 20mmHg/L/min Compliance: Cveins 19x Cartery Blood Volume: Mean Circulatory Pressure = 7mmHg CO: independent variable Vascular Function Curve Vascular Function Curve Factors that affect Vascular Function Curve 1) Volume: shifts parallel 2) Resistance: Rotates 3) Venous Compliance: -Changes mean circulatory pressure (+) venous Com = (-) MCP -Venous Compliance also changes slope Cardiac output = Venous Return Cardiac Function = Curve Starling Curve Equilibrium Point = where CV system is operating CO = 5 CVP = 2, only point that really exists Increased Blood Volume (-) inotropic state (+) Afterload (-HR) (+) HR (-) Afterload (+) Inotropic state Decresed Blood Volume Increase SVR Decrease SVR
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Transcript of Vascular Function Curve
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Qheart = 0L/min
t0: Q = 0Qresistance vessles = 0L/min
Parteries = 7mmHgPveins = 7mmHg
t0: Q = 0Mean Circulatory Pressure or Static Pressure = 7mmHgCompliance and Volume only factorsFlow = 0
1)Stepwise increase in COSee how CVP changes
SVR = 20mmHg/L/min
Cardiace Output increase = decrease in CVP
t1: Q = 1Initial increase in CO-Blood redistributes from Venous circulaiton-Blood accumulates in Arterial circulationthis is due to an IMBALANCE between output from the Heart and Resistance vessles T1: Q = 1
Qrv < (Qco =1)
Pressure hereincreasesPressure
Here decreases
P here providesDriving Force requiredto Match ow throughResistance vessels with
CO
P
P depends on SVR
Qvein = Qresistance vessels
Veins Resistance Vs
= Volume = 1
19191 Pressure
Compliance xCompliance x 1919
Pressure1919
constant, same for veins and resistance vessles
dV = C x dP
Compliance Arteries = 1Compliance Veins = 19
dPveins = 1 dPresist vs = 19
Card
iac
Out
put L
/min
CVP mmHg
1
2
3
4
5
6
7
-1 0 1 2 3 4 5 6 7 8 9
8
9
Mean Circulatory
Pressure = 7mm
Hg
Cardiac output0 1 2 3 4 5 6 7
140
130
120
110
100
90
80
70
60
50
40
30
20
10
0
Arterial Pressure m
mH
g
7
6
5
4
3
2
1
0
-1
Veno
us P
ress
ure
mm
Hg
Resistance: 20mmHg/L/minCompliance: Cveins 19x Cartery
Blood Volume: Mean Circulatory Pressure = 7mmHg
CO: independent variable
Vascular Function Curve
Vascular Function Curve
Factors that aect Vascular Function Curve1) Volume: shifts parallel2) Resistance: Rotates3) Venous Compliance: -Changes mean circulatory pressure (+) venous Com = (-) MCP -Venous Compliance also changes slope
Cardiac output = Venous Return
Cardi
ac Fu
nctio
n = Cu
rve St
arling
Curve
Equilibrium Point = where CV system is operatingCO = 5 CVP = 2, only point that really exists
Increased Blood Volume
(-) inotropic state(+) Afterload(-HR)
(+) HR(-) Afterload(+) Inotropic state
Decresed Blood Volume
Increase SVR
Decrease SVR
