Vascular Function Curve

Qheart = 0L/min t0: Q = 0 Qresistance vessles = 0L/min Parteries = 7mmHg Pveins = 7mmHg t0: Q = 0 Mean Circulatory Pressure or Static Pressure = 7mmHg Compliance and Volume only factors Flow = 0 1)Stepwise increase in CO See how CVP changes SVR = 20mmHg/L/min Cardiace Output increase = decrease in CVP t1: Q = 1 Initial increase in CO -Blood redistributes from Venous circulaiton -Blood accumulates in Arterial circulation this is due to an IMBALANCE between output from the Heart and Resistance vessles T1: Q = 1 Qrv < (Qco =1) Pressure here increases Pressure Here decreases ΔP here provides Driving Force required to Match ﬂow through Resistance vessels with CO ΔP ΔP depends on SVR Qvein = Qresistance vessels Veins Resistance Vs = Volume = 1 19 19 1 Pressure Compliance x Compliance x 19 19 Pressure 19 19 constant, same for veins and resistance vessles dV = C x dP Compliance Arteries = 1 Compliance Veins = 19 dPveins = 1 dPresist vs = 19 Cardiac Output L/min CVP mmHg 1 2 3 4 5 6 7 -1 0 1 2 3 4 5 6 7 8 9 8 9 Mean Circulatory Pressure = 7mmHg Cardiac output 0 1 2 3 4 5 6 7 140 130 120 110 100 90 80 70 60 50 40 30 20 10 0 Arterial Pressure mmHg 7 6 5 4 3 2 1 0 -1 Venous Pressure mmHg Resistance: 20mmHg/L/min Compliance: Cveins 19x Cartery Blood Volume: Mean Circulatory Pressure = 7mmHg CO: independent variable Vascular Function Curve Vascular Function Curve Factors that aﬀect Vascular Function Curve 1) Volume: shifts parallel 2) Resistance: Rotates 3) Venous Compliance: -Changes mean circulatory pressure (+) venous Com = (-) MCP -Venous Compliance also changes slope Cardiac output = Venous Return Cardiac Function = Curve Starling Curve Equilibrium Point = where CV system is operating CO = 5 CVP = 2, only point that really exists Increased Blood Volume (-) inotropic state (+) Afterload (-HR) (+) HR (-) Afterload (+) Inotropic state Decresed Blood Volume Increase SVR Decrease SVR

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Transcript of Vascular Function Curve

Qheart = 0L/min

t0: Q = 0Qresistance vessles = 0L/min

Parteries = 7mmHgPveins = 7mmHg

t0: Q = 0Mean Circulatory Pressure or Static Pressure = 7mmHgCompliance and Volume only factorsFlow = 0

1)Stepwise increase in COSee how CVP changes

SVR = 20mmHg/L/min

Cardiace Output increase = decrease in CVP

t1: Q = 1Initial increase in CO-Blood redistributes from Venous circulaiton-Blood accumulates in Arterial circulationthis is due to an IMBALANCE between output from the Heart and Resistance vessles T1: Q = 1

Qrv < (Qco =1)

Pressure hereincreasesPressure

Here decreases

P here providesDriving Force requiredto Match ow throughResistance vessels with

CO

P

P depends on SVR

Qvein = Qresistance vessels

Veins Resistance Vs

= Volume = 1

19191 Pressure

Compliance xCompliance x 1919

Pressure1919

constant, same for veins and resistance vessles

dV = C x dP

Compliance Arteries = 1Compliance Veins = 19

dPveins = 1 dPresist vs = 19

Card

iac

Out

put L

/min

CVP mmHg

1

2

3

4

5

6

7

-1 0 1 2 3 4 5 6 7 8 9

8

9

Mean Circulatory

Pressure = 7mm

Hg

Cardiac output0 1 2 3 4 5 6 7

140

130

120

110

100

90

80

70

60

50

40

30

20

10

0

Arterial Pressure m

mH

g

7

6

5

4

3

2

1

0

-1

Veno

us P

ress

ure

mm

Hg

Resistance: 20mmHg/L/minCompliance: Cveins 19x Cartery

Blood Volume: Mean Circulatory Pressure = 7mmHg

CO: independent variable

Vascular Function Curve

Vascular Function Curve

Factors that aect Vascular Function Curve1) Volume: shifts parallel2) Resistance: Rotates3) Venous Compliance: -Changes mean circulatory pressure (+) venous Com = (-) MCP -Venous Compliance also changes slope

Cardiac output = Venous Return

Cardi

ac Fu

nctio

n = Cu

rve St

arling

Curve

Equilibrium Point = where CV system is operatingCO = 5 CVP = 2, only point that really exists

Increased Blood Volume

(-) inotropic state(+) Afterload(-HR)

(+) HR(-) Afterload(+) Inotropic state

Decresed Blood Volume

Increase SVR

Decrease SVR