VARIATIONS IN REFERENCE VALUES UTILIZED IN PULMONARY FUNCTION TESTS
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Transcript of VARIATIONS IN REFERENCE VALUES UTILIZED IN PULMONARY FUNCTION TESTS
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Süleyman Savaş Hacıevliyagil, Levent Cem Mutlu, Gazi Gülbaş, Özkan Yetkin, Hakan Günen
Inonu University Faculty of Medicine Department of Pulmonary Medicine
Malatya, TURKEY
VARIATIONS IN REFERENCE VALUES UTILIZED IN
PULMONARY FUNCTION TESTS
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Introduction
Pulmonary function tests (PFT) are used to evaluate and stage the abnormalities in the functions of the respiratory system.
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Introduction
• Results of PFT measurements are defined according to the comparisons made with the reference values obtained by using sex, height and age parameters in healthy individuals.
• In our country, usually, Knudson’s reference values are used in PFT measurements.
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Aim
The aim of this study is to investigate whether these reference values are suitable for our region or not.
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Material and Methods
311 non-smoker individuals living in Malatya, over 18, without any respiratory symptom or respiratory disease in the past were included in the study using stratified cluster sampling method.
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Material and Methods
• All subjects performed forced vital capacity maneuver, and their PFTs were measured at least for three times.
• FVC, FEV1, FEV1/FVC, FEF25-75 and PEF parameters were used in our evaluations.
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Material and Methods
For these parameters, new formulations deriving from regression curves were obtained using independent parameters age and height, separately for both sexes.
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Material and Methods
The best PFT measurements were compared with the Knudson’s reference values using student-t test.
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Results
• 311 participants
• 189 males, 122 females
• Age: 45.6±17.2 years
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Constant Height Age r2 p SEE
Females
FVC -1.685 -0.00352 -0.00210 0.728 0.000 0.31108
FEV1 -0.876 0.00267 -0.00181 0.685 0.000 0.28238
FEV1/FVC 245.922 -841 -441 0.010 0.562 72.27523
FEF%25-75 0.648 0.002128 -0.0303 0.237 0.487 0.73952
PEF -6.011 0.007029 -0.00147 0.323 0.000 0.80909
Males
FVC -5.065 -0.00619 -0.00273 0.743 0.000 0.48926
FEV1 -3.160 0.0047 -0.00287 0.781 0.000 0.40290
FEV1/FVC 114.609 -141 -122 0.37 0.031 9.81641
FEF%25-75 -0.329 0.00277 -0.00349 0.282 0.000 0.94770
PEF -0.347 0.00530 -0.00411 0.124 0.100 2.10799
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Current study Values according to Knudsons’
reference values
Differences p
Females
FVC 2.96±0.53 2.87±0.59 0.089±0.31 0.002
FEV1 2.52±0.49 2.48±0.50 0.0307±0.27 0.211
FEV1/FVC 83.67±3.50 95.79±81.1 -12.13±80.8 0.145
FEF%25-75 2.96±0.45 2.61±0.82 0.34±0.79 0.006
PEF 5.83±0.64 4.23±0.96 1.59±0.77 0.000
Males
FVC 4.09±0.92 4.14±0.95 -0.042±0.49 0.235
FEV1 3.37±0.82 3.46±0.85 -0.096±0.39 0.001
FEV1/FVC 81.4±3.03 83.9±8.45 -2.51±7.69 0.000
FEF%25-75 3.73±0.70 3.28±1.1 0.45±0.97 0.000
PEF 8.27±0.84 6.59±2.22 1.68±2.1 0.000
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Tartışma
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Conclusions
• In conclusion, we have found some variations between the Knudson’s reference values and our PFT values obtained from healthy individuals in our region.
• We think that the definition of accurate reference values in our country may enable the clinicians better evaluate the patients.
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Goal
To achieve this goal, it is necessary to perform multicentric studies.