Vanderbilt Medical Device Pipeline 2016
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Medical Device Pipeline 2016 IMAGE-GUIDED SURGERY | SURGICAL ROBOTICS | NON-ROBOTIC SURGICAL TOOLS | REHABILITATION TECHNOLOGIES | CATHETERS | BIOMEDICAL PHOTONICS | NEUROSURGERY DEVICES | CARDIOVASCULAR DEVICES | HEALTH CARE ACCESSORY DEVICES | GI/ENDOSCOPY DEVICES | BIOMEDICAL RESEARCH/DIAGNOSTIC DEVICES
Transcript of Vanderbilt Medical Device Pipeline 2016
Medical Device Pipeline2016
IMAGE-GUIDED SURGERY | SURGICAL ROBOTICS | NON-ROBOTICSURGICAL TOOLS | REHABILITATION TECHNOLOGIES | CATHETERS |
BIOMEDICAL PHOTONICS | NEUROSURGERY DEVICES | CARDIOVASCULAR DEVICES | HEALTH CARE ACCESSORY DEVICES | GI/ENDOSCOPY
DEVICES | BIOMEDICAL RESEARCH/DIAGNOSTIC DEVICES
Who we areThe Center for Technology Transfer and Commercialization (CTTC) provides professional technology commercialization services to the Vanderbilt community, so that we may optimize the flow of innovation to the marketplace and generate revenue that supports future research activities.
CTTC accomplishes this by serving as an efficient and effective conduit for the transfer of promising Vanderbilt intellectual property to industry; contributing to regional economic development by licensing locally and supporting new venture creation; and encouraging collaboration between academia and industry.
Industry CollaborationKey to carrying out the mission of CTTC is the ability to form collaborative and professional relationships with companies in a variety of industries including space exploration, education, pharmaceuticals, healthcare/patient care, robotics, energy, environmental preservation, engineering, and many more. CTTC does this through:• Strategic Negotiation - Timely transactions are as critical for us as they are for our industry
partners. We pay careful attention to negotiation timelines and work to ensure high levels of responsiveness and rapid closing of negotiations
• Reasonable Diligence - Licenses must include reasonable diligence provisions to ensure that products based on Vanderbilt technology are developed and commercialized in a timely fashion for our benefit and the benefit of the public.
• Societal Benefit - Our motivations for commercializations are deeply rooted in benefiting individuals and patients on a global scale.
• Protection leads to Commercialization - CTTC views IP protection as a means to an end. The real focus is on commercialization of technologies.
• Focused on Transactions - CTTC’s experienced team of licensing professionals are highly transactionally focused.
Table of Contents
Vanderbilt Medical Device Core Research Capabilites..........................................3 Center for Intelligent Mechatronics Department of Biomedical Informatics Vanderbilt Initiative in Surgery & Engineering Vanderbilt University Institute of Imaging Science Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE) Vanderbilt Institute of Nanoscale Science and Engineering (VINSE) Vanderbilt Clinical Translational Science Award (CTSA) Medical Device Regulatory Affairs Program (MDRAP)Image Guided Surgery Pipeline.............................................................................4Surgical Robotics Pipeline......................................................................................5Non-Robotic Surgical Tools....................................................................................6Rehabilitation Technologies, Catheters..................................................................7Biomedical Photonics.............................................................................................8Neurosurgery Devices...........................................................................................9Cardiovascular Devices.......................................................................................10Health Care Accessory Devices...........................................................................11GI/Endoscopy Devices........................................................................................12Biomedical Research/Diagnostic Devices...........................................................13
Medical Device Pipeline2016
2Compiled by Masood Machingal, Ph.D., CTTC licensing officer
Contact Dr. Machingal at 615.353.3348 or [email protected]
Institute of Imaging Science (VUIIS)VUIIS operates state-of-the-art facilities for imaging research at all scales including imaging animals and human subjects. Areas of focus include: cancer, neurological disorders, metabolic disorders, cardiovascular disease, and others.
Initiative in Surgery and Engineering (ViSE)ViSE is an interdisciplinary, trans-institutional center focused on the creation, development, implementation, clinical evaluation and commercialization of methods, devices, algorithms, and systems designed to facilitate interventional processes and their outcome. Areas of focus include: image-guided surgery; intelligent, flexible robotic manipulation; ultrasound guidance for surgical interventions; steerable needles; wireless capsule robotics, etc.
Institute of Nanoscale Science and Engineering (VINSE)VINSE is focused on new science and technology based on nanoscale materials. Researchers team locally and globally, providing an environment where physicists, chemists, biologists, and engineers may collaboratively solve forefront problems and create new scientific understanding. Areas of focus include: nanobio, nanoscale electronics and optics, nanoscience theory, nanotechnology and new materials.
Department of Biomedical Informatics (DBMI)Vanderbilt’s DBMI is the largest academic department of biomedical informatics in the country, with more than 65 faculty members. Areas of focus include: computer science, information science, cognitive science, social science, engineering, and clinical and basic biological sciences.
Institute for Integrative Biosystems Research and Education (VIIBRE)VIIBRE invents the tools and develops the skills that are required to conduct research in systems biology. Areas of focus include: cellular biosensors, bioprocess controllers, mathematical models for wound healing and cancer, infectious disease detection, biomedical imaging, and cellular/tissue engineering.
Medical Device Regulatory Affairs Program (MDRAP)Vanderbilt’s Medical Device Regulatory Affairs Program (MDRAP), supports investigators who are involved with Food and Drug Administration (FDA) regulated device research. It provides a list of services including early device development guidance, regulatory guidance, Investigation Device Exemptions support, and more.
Clinical Translational Science Award (CTSA)In 2007 Vanderbilt University received a $40 million Clinical and Translational Science Award (CTSA) grant, the largest single government research grant in Vanderbilt’s history, to expedite the translation of laboratory discoveries to patients in the community. This NIH grant helps fund the Vanderbilt Institute for Clinical and Translational Research (VICTR), which supports the translation of fundamental scientific discoveries into clinical practice and brings basic and clinical researchers together. VICTR provides access to resources, training and collaboration, and informatics and biostatistical systems.
In 2011 Vanderbilt was awarded a renewal of $46 million as well as a $20 million grant to be the Coordinating Center for the CTSA consortium, which now includes 60 institutions in 30 states and the District of Columbia.
Center for Intelligent Mechatronics (CIM)Under the direction of Michael Goldfarb, Ph.D., Vanderbilt University’s Center for Intelligent Mechatronics (CIM) has created a portfolio of rehabilitation robotics. Current projects include a powered, multi-degree-of-freedom prosthetic arm, a powered exoskeleton for gait restoration in spinal-cord injured victims and stroke rehabilitations, and a powered transfemoral prosthesis that enhances mobility and reduces falls for lower-limb amputees.
Core Research Capabilities
In the spring of 2014, Vanderbilt University’s Board of Trust approved construction of a 230,000-square-foot Engineering and Science Building that will foster project teamwork and offer programs, instrumentation areas and core research space that will promote interdisciplinary work, particularly in engineering and related fields. Rendering courtesty of: Wilson Architects/Vanderbilt University
The 2016 Medical Device Pipeline highlights Vanderbilt’s current pipeline of technologies that are the product of the university’s commitment to collaborative, applied research in the fields of engineering and medicine. Vanderbilt has a number of Centers, Departments and Institutions that are paving the way for engineers and clinicians to work together to find innovative solutions to the world’s health problems.
Vanderbilt University 2016 Medical Device Pipeline
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
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Type/
Status/
Serial #
Galloway
Miga
DawantImage Guided Surgical Navigation (Portfolio)
Portfolio of
Multiple Patents
Konrad
Dawant
Surgical Planning and Navigation Software for
Deep Brain Stimulation (Portfolio)Portfolio of
Multiple Patents
Labadie
Fitzpatrick
System and Methods of Using Image-guidance
for Placement of Cochlear Stimulator DevicesIssued US
8380288
GallowayImage-Guided Navigation System for
Endoscopic Eye SurgeryIssued US
8403828
MigaLaser Range Scanning for Cortical Surface
Registration & Deformation Tracking
Issued US
7103399 and
7647087
Miga
Method to model elasticity parameters (i.e.
elastography) of tissue as a complement to
imaging
Issued US
7257244
MigaBrain Shift Compensation Using Computer
ModelsIssued US
7072705
MigaModel-Based Compression Correction
Framework for UltrasoundPatent Pending
MigaImage Guidance System for Breast Cancer
SurgeriesPatent Pending
Miga
A Novel Trackerless Image Guided Soft Tissue
Surgical Design for Use with Surgical
Microscopes or Similar Technologies
Patent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website
Image Guided SurgeryTechnology
Development
Technology
Demonstration
Seeking Partners Partnered
4
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
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Type/
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Serial #
Simaan Insertable Robotic Effector Platform PortfolioPortfolio of
Multiple Patents
& Copyrights
Webster
Barth
Precision Pneumatic Robot for MRI-Guided
NeurosurgeryPublished US
20130123802 A1
SimaanMinimallly Invasive Robotic Platform for
Transurethral Exploration and InterventionPublished US
20140316434 A1
SimaanLow Cost Dexterous Wrists for Surgical
Intervention
Published US
20150073434A1,
Published PCT
WO2013158974
SimaanMethods for Quick and Safe Deep Access into
Mammalian AnatomyPublished PCT
WO2013158983
SimaanAlgorithms for Compliant Insertion and Motion
Control of Continuum Robots
Published US
20140330432A1,
Published PCT
WO2013158978
SimaanAlgorithms for Contact Detection and Contact
Localization in Continuum RobotsPublished US
20130300537 A1
ValdastriWireless Tissue Palpation for Minimally Invasive
Robotic Surgery TechniquesPublished US
20140081120 A1
WebsterSteerable Needles: A Better Turning Radius with
Less Tissue DamagePublished US
20140276586 A1
SimaanAlgorithms and Methods for Motion and Force
Control of Continuum RobotsCopyrights
Webster Flexible Instrument with Precurved ElementsPublished US
20160016319 A1
WebsterA Robotic System for Treating Intracranial
Hemorrhage (ICH)Published US
20150223832 A1
Click the technology title for viewing a detailed
Technology Summary on CTTC website Seeking Partners Partnered
Surgical RoboticsTechnology
Development
Technology
Demonstration
5
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
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Serial #
WebsterA Tip for Surgical Devices with Arc Length
Varying CurvaturePatent Pending
WebsterHand-Held Concentric Tube Manipulator
Actuation Unit and Mechanism for SurgeryPatent Pending
Webster Steerable Biopsy Devices Patent Pending
WebsterModular, Sterilizable Robotic System for
Endonasal SurgeryPatent Pending
WebsterA System for Transoral Targeting of Suspicious
Nodules in the BodyPatent Pending
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
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Animal
model
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Clinical
trials
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Webster
MAESTRO: Non-Robotic Dexterous Laproscopic
Instrument with a Wrist providing Seven
Degrees of Freedom (Portfolio)
Published Apps
US20120277762
WO2015168441
US20150080908
WebsterGRASP: Grasping Applicator for Surgical
PositioningPublished US
20140277105 A1
Geiger SureTight: GI Anastamosis Leak Detection Patent Pending
WebsterCombined Powered Core Needle and FNA
Biopsy DevicePatent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website
Non Robotic Surgical ToolsTechnology
Development
Technology
Demonstration
Seeking Partners Partnered
Surgical Robotics (continued)Technology
Development
Technology
Demonstration
6
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
o
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u
m
Type/
Status/
Serial #
GoldfarbVanderbilt Exoskeleton: Powered Lower-Limb
Exoskeleton for ParaplegiaPortfolio of
Multiple Patents
GoldfarbPowered Robotic Knee and Ankle Prosthesis for
Transfemoral AmputeesPortfolio of
Multiple Patents
GoldfarbVanderbilt Multigrasp Myoelectric Prosthetic
HandPortfolio of
Multiple Patents
Sarkar
IntelliCane: Instrumented cane for diagnosis
and evaluation of gait behavior in individuals
with mobility issues
Pending US
Schoenecker3DMD Smartcasting System for Predictive
Clubfoot CorrectionPending US
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
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Type/
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Serial #
Eagle
Point of Care Device for Confirmation of IV
Catheter Placement & Measurement of Venous
Pressures
Portfolio of
Patents
MerrymanCatheter Having Temperature Controlled
Anchor and Related MethodsPublished US
20130296851 A1
Sawyer Transductive Access CatheterPublished US
20120172750 A1
Nicholson Track-Star Angiographic Catheter Patent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website
CathetersTechnology
Demonstration
Technology
Development
Rehabilitation TechnologiesTechnology
Development
Technology
Demonstration
Seeking Partners Partnered
7
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
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Type/
Status/
Serial #
Mahadevan-
Jansen
Near Infrared Fluorescence for Parathyroid
Identification (Portfolio)Portfolio of
Multiple Patents
Jansen
Mahadevan-
Jansen
Systems and Methods for Optical Stimulation of
Neural Tissues (Portfolio)Portfolio of
Multiple Patents
Mahadevan-
Jansen
Breast Tumor Margin Detection System Using
Spatially Offset Raman Spectroscopy
Issued US
9020581 and
Pending US
14/085732
Mahadevan-
Jansen
Non-Invasive Skin Cancer Detection using
Raman Spectroscopy-OCT System
Issued US
7508524
8,00220 and
8553219
Mahadevan-
Jansen
Trimodal Handheld Probe Based on Raman
Spectroscopy and Confocal Imaging for Cancer
Detection
Issued US
8300220
JoosMiniature Optical Coherence Tomography
Probe for Real-time Monitoring of Surgery
Issued US
8655431 and
9014788;
Pending PCT
US, EU, and CA
Weiss
Porous Silicon Membrane Waveguide
Biosensors for high sensitivity detection of low
molecular weight biological or chemical targets
Issued US
8506887
WeissFunctionalized optical sensors comprising
diffraction gratings on porous silicon structuresIssued US
8349617
WeissPorous Silicon Waveguide Integrated Optical
Microring Resonator For Label-Free BiosensingPatent Pending
Mahadevan-
Jansen
Noninvasive Monitoring of Infection in
Neonates Using Optical MeansPatent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website
Biomedical Photonics Technology
Development
Technology
Demonstration
Seeking Partners Partnered
8
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
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Type/
Status/
Serial #
Fitzpatrick
System and Methods for Determining
Orientation of Bone Implanted Post for
Cochlear and Deep Brain Stimulation
Portfolio of
Patents
FitzpatrickPosiSeat™: Assured Seating of Threaded
Surgical ComponentsIssued US
8231636
Kao Flat-Cut Bit for Cranial PerforatorIssued US
8152809
Webster
Barth
Precision Pneumatic Robot for MRI-Guided
NeurosurgeryPublished US
20130123802 A1
Labadie
Fitzpatrick
System and Methods of Using Image-guidance
for Placement of Cochlear Stimulator Devices
and Drug Carrier Devices
Issued US
8380288
Kao
Konrad
Fitzptrick
Labadie
Adjustable Universal Platform for Surgical
Navigation, Approach, and Implantation
Issued US
8414597 and
7794469
Click the technology title for viewing a detailed
Technology Summary on CTTC website
Technology
Development
Technology
Demonstration
PartneredSeeking Partners
Neurosurgery Devices
9
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
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Type/
Status/
Serial #
Eagle
Point of Care Device for Confirmation of IV
Catheter Placement & Measurement of Venous
Pressures
Portfolio of
Patents
Brophy Autologous Vein Harvest Kit Portfolio of
Patents
Eagle
Baudenbach
er12 Lead Smart ECG Monitor
Portfolio of
Patents
MerrymanCatheter Having Temperature Controlled
Anchor and Related MethodsPublished US
20130296851 A1
Sawyer Transductive Access CatheterPublished US
20120172750 A1
ByramAn Adaptive Clutter Demodulation Scheme for
Measuring Low Velocity Blood using UltrasoundPatent Pending
Hak-Joon
Sung
Shape Memory External Stents for Vascular
ApplicationsPatent Pending
Froehler Closed-End Stent for Aneurysm Embolization Patent Pending
Nicholson Track-Star Angiographic Catheter Patent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website Seeking Partners Partnered
Technology
Development
Technology
Demonstration Cardiovascular Devices
10
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
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Status/
Serial #
BreamMaximum Barrier Sterile Drape for Neck and
Upper ChestPortolio of
Patents
Gupta
Collapsible Lightweight Portable Leg Holder for
Ultrasound Guided Lateral Popliteal Block
Procedures
Patent Pending
GuptaRapidly Adjustable Flexible Positioning Arm for
Ultrasound Probe -Clinician's Third HandPatent Pending
Self
Sterile blood culture collection kit for reducing
blood culture contamination at healthcare
institutions
Pending US
Baudenbach
er
Automated Abdominal Binder for Treatment of
Orthostatic Hypotension
Published US
201503136008
A1
LathropStable Mount for Head Attached Optical
Tracking MarkerPatent Pending
Lathrop Medical Respirator Breathing Tube Support Patent Pending
Shinar Ventilation Vest for Surgical Spacesuites Patent Pending
Schlesinger DynoAlarm: Smart Patient Monitoring Alarm Patent Pending
Alvis Universal Smart Phone Video Laryngoscope Patent Pending
ByramA Hand Held Device for Quantitative
Assessment of Tissue StiffnessPatent Pending
Doyle Self Expanding Ductal Occluder Patent Pending
GricePortable Flow Phantom for Doppler Ultrasound
Quality MeasurementsPatent Pending
NicholsSingle-handed Side-loading Guidewire Torque
Device for Interventional Medical Procedures Patent Pending
Guy Central Line Burn Dressing Patent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website
Technology
Development
Technology
Demonstration
Seeking Partners Partnered
Health Care Accessory Devices
11
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
o
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Type/
Status/
Serial #
VaeziDevice for Detecting and Measuring Conditions
of Esophageal MucosaPortfolio of
Patents
ValdastriLocal Magnetic Actuation for Minimally Invasive
Surgery Published US
20130298715 A1
ValdastriWireless Tissue Palpation for Minimally Invasive
Robotic Surgery TechniquesPublished US
20140081120 A1
ValdastriReal-time Pose and Magnetic Force Detection
for a Wireless Magnetic CapsulePublished PCT
WO 2014113697
Valdastri Robotic Platform for Mini-Invasive Surgery Pending US
ValdastriHydro-Jet Endoscopic Capsule for Gastric Cancer
Screening in Low Resource SettingsPending PCT
Geiger SureTight: GI Anastamosis Leak Detection Patent Pending
Valdastri
Image Partitioning and Illumination in Image-
Based Pose Detection for Teleoperated Flexible
Endoscopes
Copyrights
ObsteinWireless Tablet App for Remote Collaboration
and Training in ColonoscopyCopyrights
Click the technology title for viewing a detailed
Technology Summary on CTTC website Partnered
Technology
Demonstration GI/Endoscopy Devices Technology
Development
Seeking Partners
12
Vanderbilt University 2016 Medical Device Pipeline
Basic
ResearchFeasibility IP Status
Lead
Inventor TechnologyDiscovery
and
ideation
Invention
and
prototyping
Lab
prototype
validation
Animal
model
validation
Clinical
trials
Regulatory
process
C
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Type/
Status/
Serial #
Wikswo
Rotary planar peristaltic micropump (RPPM)
and Rotary Planar Valve (RPV) for microfluidic
systems
Published EPO
2625425,
Published US
20130287613 A1
Baudenbach
erThermal ELISA
Published US
20150160205 A1
Weiss
Easy-to-Fabricate, Cost-Effective, and Stable
Surface Enhanced Raman Scattering (SERS)
substrates
Published EPO
2619532,
Pending Canada,
Pending US
Weiss Porous Silicon Membrane Waveguide BiosensorIssued US
8506887
Haselton
Extractionator: Low Resource Extraction and
Processing of Biological Samples Using Surface
Tension Valves
Published PCT
WO2012009627
A1, Pending US
Mahadevan-
Jansen
Non-Invasive, Early Monitoring of Neonatal
infection Using Optical MeansPatent Pending
CyrPoint of Care Rheological Flow Assay for
Diagnosis and Monitoring of DiseasePatent Pending
Click the technology title for viewing a detailed
Technology Summary on CTTC website
Technology
Demonstration
Seeking Partners Partnered
Biomedical Research/Diagnostic DevicesTechnology
Development
13
Vanderbilt technologies available for licensing and collaboration:
visit www.vanderbilt.edu/cttc/technologies
View the 2016 Medical Device Pipeline or one of Vanderbilt’s other Technology Pipelines:
www.vanderbilt.edu/cttc/industry/technology-portfolios
Find us online:
For more information about CTTC: www.vanderbilt.edu/cttc
For more information about these technologies: www.vanderbilt.edu/cttc/technologies
Find us /VanderbiltCTTC
Vanderbilt’s geographically unified campus is integral in the university’s pursuit of excellence in clinical and translational research.
Vanderbilt University is ranked 15th among the best national universities.
Vanderbilt sponsored research and project awards total $681.7 million.
Vanderbilt University School of Medicine Ranks 10th in NIH Funding with $294 million.
The School of Engineering ranks 35th for graduate engineering programs.
Vanderbilt is home to one of the oldest Biomedical Engineering Departments in the country, dating back to 1968.
Vanderbilt is a Clinical Translational Science Award Coordinating Center, leading 60 CTSA institutions in 30 states and the District of Columbia.
Vanderbilt Research Quick FactsCTTC Highlights FY15
Invention Disclosures 179U.S. Patent Applications Filed 187U.S. Patents Issued 54
Revenues from Licensing $9M
Licenses/Options Executed 98
