Valli Muthappan, M.D. Sightline Ophthalmic Associates...
Transcript of Valli Muthappan, M.D. Sightline Ophthalmic Associates...
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Valli Muthappan, M.D.
Sightline Ophthalmic Associates
February 22, 2015
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Pterygium
Band Keratopathy
Non-healing epithelial defects
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Sun and exposure related degeneration of conjunctiva
“elastotic degeneration”
Usually nasal, sometimes temporal
Iron line (stocker line)
Preceded by a pingeculum
“atypical pterygium” = think about CIN!
Pterygium
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Pingueculum Does not go onto cornea
Often bilateral
Often asymptomatic
Pterygium Starts encroaching on
cornea
Prominent vascularity
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Treatment of pterygia Treat the symptoms
Asymptomatic
Dryness
Inflammation
Astigmatism
Medical treatment
Frequent lubrication
Topical steroids
Reduce UV exposure (sunglasses)
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Reasons to remove pterygia Threatening visual axis
Significant (irregular) astigmatism
Symptomatic dry eye
Restricting ocular motility
Cosmesis
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Surgical approach Dissect away diseased
tissue – mostly Tenon’s
Some surgeons advocate an extensive tenonectomy to reduce recurrence
Biggest area of debate is how to close conjunctival defect
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Type of closure Advantages Disadvantages
Bare sclera Fast Highest rate of recurrence
Simple closure No need to harvest tissue Only works with small defects
Amniotic membrane
Don’t need to harvest tissue (good for patients with previous retina/glacuoma surgery)
Extensive suturing or gluing required
Conjunctival graft
Least recurrence rate; best outcomes; “gold standard”
Need to harvest from another location in same patient; can use for large defects
Sutures Most stable Moderate cosmesis, can be irritating, longer surgery
Fibrin glue Faster surgery, more comfortable post op, possibly better cosmesis and less recurrence
Less stable; blood related product (newest: use patients own blood as a form of glue)
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Post-operative care BCL can be placed at time of surgery for comfort
Epi defect on cornea
Removed at 1 week
Sutures can be irritating and removed after 2-3 weeks
Course of antibiotics for 1 week-1 month
Course of steroids for 1-3 months
Frequent artificial tears
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Calcium deposits in Bowman’s layer
Peripheral clear zone between limbus and lesion
With time, grow towards center of cornea in interpalpebral fissure
Band Keratopathy
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Causes of BK Chronic (inflammatory) ocular disease
JIA, IK, phthsis bulbi
Chronic severe dry eye Hypercalcemia
Sarcoidosis!
Elevated serum phosporous renal failure
Chronic exposure to mercury Old generation of eye drops Causes changes in collagen allowing deposition of calcium
Silicone oil (esp in aphakia) Idiopathic
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Reasons for treatment First work up the condition if underlying cause
unknown
Treat ocular surface with lubrication
Consider procedure when its visually significant
Crossing central visual axis with decreased BSCVA
Extreme discomfort
Will recur unless underlying process is treated
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Surgical approach Chelation with neutral solution
Remove epithelium but do not damage Bowmans Membrane
Disodium EDTA (compounded) in cylindrical reservoir
BCL
PTK not primary treatment Calcium ablates at different rate
from stroma -> irregular surface
Can use as secondary treatment if some residual calcium
Treatment can be repeated
Na
Ca
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Post operative care BCL
Antibiotics until surface healed
Monitor and repeat treatment if/when recurs
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What causes a NHED? Poor tear film
Neurotrophic conditions (check corneal sensation!) DM, s/p PKP, herpetic disease, cranial nerve 5 damage
Exposure Cranial nerve 7 palsy, bad lids
Inflammatory Post infectious, autoimmune
Medications Topical anesthetics, topical NSAIDs, CAIs, trifluridine,
topical steroids, BAK…almost anything!
Stem cell defects
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Mackie classification of neutrophic keratopathy Stage 1 – mild/non specific
Decreased TBUT; staining of conjuctiva; SPK
Stage 2 – non healing epithelial defect
Epithelium becomes loose; DM folds with stromal swelling, oval/punched out shape, smooth/rolled edges
Stage 3 – stromal melt
Thinned cornea, can lead to peforation
1. Patient may be asymptomatic
2. Check corneal sensation
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How to treat a NHED Treat underlying disease
Treat medically/locally
“TEARS, TEARS, TEARS, until they are coming out of your ears!”
Lubrication (PFATs, gel/ointment)
Punctal occlusion or cautery
Improve tear quality
Warm compresses/lid scrubs, tetracyclines, omega-3 supplements, autologous serum
Restasis, topical progesterone drops
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BCL Easy, in office, quick
Provides comfort
Promotes healing
Cover with an antibiotic
Can even consider long term for patient with chronic disease – if patient can learn to place/remove CLs
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Amniotic membrane transplant Inner most layer of placenta
Thick basement membrane and avascular stromal matrix – similar structure to conjunctiva
Augments support for limbal stem cells
Decreased fibroblast reproduction/differentiation
Reduces protease activity
Helps with acute healing - does not solve underlying problem
Some theoretical risk of transmitted diseases (none reported)
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Nguyen, P. et al. Ocular surface rehabilitation: Application of human amniotic membrane in high-risk penetrating keratoplasties. Saudi Journal of Ophthalmology, 2014 (28): 198-202.
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Ambio 2 (35-40 micron thick tissue; 9 and 12 mm versions available)
Try to keep IOP in proper orientation (BM up) – but some studies say it does not matter which way you place it, or even if its placed over epi defec
Use large diameter CL over tissue
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Prokera ring - 16 mm diameter
Prokera slim - thinner profile
Prokera plus – multiple layers of AM, lasts longer
Ring is useful to prevent symblepharon formation
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Tarsorrhaphy Keeping eye lid closed allows epithelium to heal
Tape tarsorrhaphy
Use in conjunction with AMT
Temporary sutured tarsorrhapy
Use in conjunction with AMT
Permanent sutured tarsorrhapy
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Gunderson Flap
Conjuntival flaps to cover corneal defect (perforation)
Does block vision
Can do PKP over it after eye is healed/quiet if appropriate
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NHED prognosis Depends on underlying etiology
If underlying disease under control, epithelium will follow
Chronic disease causes chronic pathology
Keep up treatment!
Permanent tarsorrhaphies may be needed
Use of disposable SCL may be helpful