Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent...
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Transcript of Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent...
![Page 1: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/1.jpg)
Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 2: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/2.jpg)
Background
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 3: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/3.jpg)
Slide 3
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 4: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/4.jpg)
RANO Criteria
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 5: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/5.jpg)
BRAIN trial (AVF3708g)
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 6: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/6.jpg)
Study design
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 7: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/7.jpg)
Response
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 8: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/8.jpg)
Inter-reader agreement
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 9: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/9.jpg)
Objective Response Rate
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 10: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/10.jpg)
Landmark analysis: Objective response versus Survival
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 11: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/11.jpg)
Progression
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 12: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/12.jpg)
Progression
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 13: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/13.jpg)
PFS: Macdonald vs RANO
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 14: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/14.jpg)
Landmark analysis: Progression vs Overall Survival
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 15: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/15.jpg)
Conclusions
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 16: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/16.jpg)
Future directions
Presented By Raymond Huang at 2014 ASCO Annual Meeting
![Page 17: Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab Presented By Raymond.](https://reader035.fdocuments.us/reader035/viewer/2022062515/56649d1a5503460f949ef234/html5/thumbnails/17.jpg)
Acknowledgement
Presented By Raymond Huang at 2014 ASCO Annual Meeting